Gene: AIFM3

150209
AIFL
apoptosis inducing factor, mitochondria associated 3
protein-coding
22q11.21
Ensembl:ENSG00000183773 MIM:617298 Vega:OTTHUMG00000150804 UniprotKB:Q96NN9
NC_000022.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.838e-2 (AD)  3.096e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs178260chr22:20970019 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNTA10.863
ZNF385A0.86
PSD20.854
ENHO0.852
SFXN50.844
VEGFB0.841
OLFM20.839
ALDOC0.83
CST30.828
TTYH10.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.607
OR4F29-0.579
GADL1-0.402
DPPA4-0.398
FER1L6-0.397
MROH5-0.396
GSDMA-0.38
KLHDC7B-0.374
RNF17-0.373
SULT1E1-0.369

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of AIFM3 mRNA"28903501
C0331461-hydroxypyrene1-hydroxypyrene results in decreased expression of AIFM3 mRNA21854004
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of AIFM3 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AIFM3 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AIFM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AIFM3 mRNA"27188386
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of AIFM3 mRNA"21854004
C547126AZM551248AZM551248 results in increased expression of AIFM3 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of AIFM3 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of AIFM3 mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of AIFM3 mRNA25181051
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of AIFM3 mRNA]19228888
C018475butyraldehydebutyraldehyde results in decreased expression of AIFM3 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of AIFM3 promoter22457795
D002166CamptothecinAIFM3 mRNA results in decreased susceptibility to Camptothecin25269479
D019327Copper SulfateCopper Sulfate results in decreased expression of AIFM3 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of AIFM3 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of AIFM3 mRNA25562108
D003976DiazinonDiazinon results in increased methylation of AIFM3 gene22964155
D019422Dietary SucroseDietary Sucrose results in increased expression of AIFM3 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AIFM3 mRNA24535843
C039281furanfuran results in decreased expression of AIFM3 mRNA24183702
D017313FenretinideFenretinide results in increased expression of AIFM3 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AIFM3 mRNA26752646
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AIFM3 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AIFM3 mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of AIFM3 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AIFM3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AIFM3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AIFM3 mRNA"25620056
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AIFM3 mRNA27935865
C046012pentanalpentanal results in decreased expression of AIFM3 mRNA26079696
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of AIFM3 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of AIFM3 mRNA19482888
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AIFM3 mRNA27935865
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AIFM3 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of AIFM3 mRNA24780913
C031280pyrazolepyrazole results in decreased expression of AIFM3 mRNA17945193
D012999SomanSoman results in decreased expression of AIFM3 mRNA19281266
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of AIFM3 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in decreased expression of AIFM3 mRNA19228888
D014284TriiodothyronineTriiodothyronine results in increased expression of AIFM3 mRNA17403546
C012589trichostatin Atrichostatin A results in decreased expression of AIFM3 mRNA24935251
C012589trichostatin Atrichostatin A results in decreased expression of AIFM3 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AIFM3 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of AIFM3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AIFM3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of AIFM3 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of AIFM3 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of AIFM3 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AIFM3 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of AIFM3 mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of AIFM3 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016491oxidoreductase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO:00515372 iron, 2 sulfur cluster binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0055114oxidation-reduction process-IEA-  
GO:0097194execution phase of apoptosis-IDA15764604  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleusNOTIDA15764604  
GO:0005739mitochondrion-IDA15764604  
GO:0005743mitochondrial inner membrane-IDA15764604  
GO:0005783endoplasmic reticulum-IDA15764604  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal