Gene: NFAM1

150372
CNAIP
NFAT activating protein with ITAM motif 1
protein-coding
22q13.2
Ensembl:ENSG00000235568 MIM:608740 Vega:OTTHUMG00000150923 UniprotKB:Q8NET5
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.301e-1 (AD)  6.099e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WAS0.918
MYO1F0.916
IL10RA0.915
RUNX10.912
PARVG0.911
PTPRC0.906
CMTM70.903
ARHGAP300.903
NCKAP1L0.898
SLC7A70.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.469
ST6GAL2-0.459
ATOH7-0.458
TMEM179-0.457
KCNIP3-0.447
MARCH4-0.446
SLC7A4-0.444
MYADML2-0.441
HAS1-0.44
ATP2C2-0.429

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of NFAM1 mRNA19191707
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NFAM1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of NFAM1 mRNA22378314
D002185CannabidiolCannabidiol results in decreased expression of NFAM1 mRNA21542829
D004397FonofosFonofos results in increased methylation of NFAM1 promoter22847954
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NFAM1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NFAM1 mRNA23086925
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NFAM1 mRNA26582142
C030589methylmercury cysteinemethylmercury cysteine results in increased expression of NFAM1 mRNA19465457
C523799MRK 003NFAM1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NFAM1 mRNA"25554681
D010278ParathionParathion results in increased methylation of NFAM1 promoter22847954
D011441PropylthiouracilPropylthiouracil results in increased expression of NFAM1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NFAM1 mRNA19073995
C012568terbufosterbufos results in increased methylation of NFAM1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFAM1 mRNA28922406
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NFAM1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NFAM1 mRNA20133372
D014635Valproic AcidValproic Acid results in increased methylation of NFAM1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NFAM1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IDA12615919  
GO ID GO Term Qualifier Evidence PubMed
GO:0001819positive regulation of cytokine production-NAS12615919  
GO:0006954inflammatory response-NAS12615919  
GO:0007165signal transduction-IDA12615919  
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0030183B cell differentiation-ISS15143214  
GO:0035556intracellular signal transduction-IDA12615919  
GO:0043312neutrophil degranulation-TAS-  
GO:0045577regulation of B cell differentiation-IEA-  
GO:0050861positive regulation of B cell receptor signaling pathway-ISS15143214  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA12615919  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IDA12615919  
GO:0035577azurophil granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22199996Tumor necrosis factor-related genes and colon and rectal cancer. (2011)Slattery MLInt J Mol Epidemiol Genet