Gene: CTRB1

1504
CTRB
chymotrypsinogen B1
protein-coding
16q23.1
Ensembl:ENSG00000168925 MIM:118890 Vega:OTTHUMG00000159272 UniprotKB:P17538
NG_051057.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.294e-1 (AD)  2.829e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CELA3A0.969
CPA10.967
CELA3B0.962
GP20.96
PLA2G1B0.956
CTRB20.954
CPB10.953
CLPS0.953
PRSS10.948
PNLIP0.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF20-0.239
PSG11-0.214
HMGA2-0.206
FGF23-0.197
ZPLD1-0.192
PCDHGB1-0.189
RNF133-0.184
DNTT-0.183
OR2L5-0.183
DNAH8-0.182

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01662Trans-O-Hydroxy-Alpha-Methyl CinnamateSmall Molecule-ExperimentalTarget
DB017042,4-Dihydroxy-Trans Cinnamic AcidSmall Molecule614-86-8ExperimentalTarget
DB01963Phenylethane Boronic AcidSmall Molecule34420-17-2ExperimentalTarget
DB03976PhosphorylisopropaneSmall MoleculeExperimentalTarget
DB06692AprotininBiotechDrug9087-70-1Approved|Investigational|WithdrawnTarget
DB073801,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)Small MoleculeExperimentalTarget
DB07383N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDESmall MoleculeExperimentalTarget
DB076683-(4-DIETHYLAMINO-2-HYDROXY-PHENYL)-2-METHYL-PROPIONIC ACIDSmall MoleculeExperimentalTarget
DB077492-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDESmall MoleculeExperimentalTarget
DB07899(2S) N-acetyl-L-alanyl-alphaL-phenylalanyl-chloroethylketoneSmall MoleculeExperimentalTarget
DB081191,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)Small MoleculeExperimentalTarget
DB08374(3S)-3-Amino-1-chloro-4-phenyl-2-butanoneSmall Molecule52735-71-4ExperimentalTarget
DB08565L-1-naphthyl-2-acetamido-ethane boronic acidSmall MoleculeExperimentalTarget
DB08566D-1-naphthyl-2-acetamido-ethane boronic acidSmall MoleculeExperimentalTarget
DB08692D-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acidSmall MoleculeExperimentalTarget
DB08693L-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0252231,4-dioxane"1,4-dioxane affects the activity of CTRB1 protein"11162681
C0252231,4-dioxane"1,4-dioxane affects the reaction [CTRB1 protein binds to Water]"15882959
C0252231,4-dioxane"CTRB1 protein binds to 1,4-dioxane"15882959
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CTRB1 mRNA"19114083
C032159acetonitrileacetonitrile affects the activity of CTRB1 protein11162681
D020106AcrylamideAcrylamide affects the expression of CTRB1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CTRB1 mRNA16483693
D001507BeclomethasoneBeclomethasone results in increased expression of CTRB1 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CTRB1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CTRB1 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of CTRB1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of CTRB1 mRNA23019147
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of CTRB1 gene28505145
D002738ChloroquineChloroquine results in decreased expression of CTRB1 mRNA19393257
D004390ChlorpyrifosChlorpyrifos results in increased expression of CTRB1 mRNA21356183
D019327Copper SulfateCopper Sulfate results in decreased expression of CTRB1 mRNA19020976
D019327Copper SulfateCopper Sulfate results in increased expression of CTRB1 mRNA19020976
D003471CuprizoneCuprizone results in increased expression of CTRB1 mRNA27523638
D003907DexamethasoneDexamethasone results in increased expression of CTRB1 mRNA22733784
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CTRB1 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CTRB1 mRNA28412506
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CTRB1 mRNA20360939
C024629dimethyl phthalatedimethyl phthalate affects the expression of CTRB1 mRNA26924002
D004147DioxinsDioxins affects the expression of CTRB1 mRNA20463971
D000431EthanolEthanol affects the activity of CTRB1 protein11162681
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CTRB1 intron27776689
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of CTRB1 gene28505145
C008261lead acetatelead acetate results in increased expression of CTRB1 mRNA22609695
D008627Mercuric ChlorideMercuric Chloride affects the expression of CTRB1 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CTRB1 mRNA23103053
C038300methylmethacrylate-methacrylic acid copolymermethylmethacrylate-methacrylic acid copolymer inhibits the reaction [CTRB1 protein binds to CTRB1 protein]14983099
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CTRB1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CTRB1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CTRB1 mRNA"25620056
C028007nickel monoxidenickel monoxide results in decreased expression of CTRB1 mRNA19167457
D000069463Olive OilOlive Oil analog affects the expression of CTRB1 mRNA17349074
D010100OxygenOxygen deficiency results in increased expression of CTRB1 protein19579223
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CTRB1 mRNA23948077
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CTRB1 mRNA18501439
D010634PhenobarbitalPhenobarbital results in increased expression of CTRB1 mRNA23091169
C014153pirimiphos methylpirimiphos methyl results in decreased expression of CTRB1 mRNA27845199
C006253pirinixic acidpirinixic acid results in increased expression of CTRB1 mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of CTRB1 mRNA23557933
C541923sandostatinLARsandostatinLAR results in decreased expression of CTRB1 mRNA17210224
C009277sodium arsenatesodium arsenate results in decreased expression of CTRB1 mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of CTRB1 mRNA22561333
D012999SomanSoman results in increased expression of CTRB1 mRNA19281266
D013605T-2 ToxinT-2 Toxin affects the expression of CTRB1 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CTRB1 mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTRB1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CTRB1 mRNA25975270
C009495titanium dioxidetitanium dioxide results in increased expression of CTRB1 mRNA23409001
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of CTRB1 mRNA17982090
D014635Valproic AcidValproic Acid results in increased methylation of CTRB1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of CTRB1 mRNA21126777
C484810VX680VX680 results in increased expression of CTRB1 mRNA18765535
D014867Water"1,4-dioxane affects the reaction [CTRB1 protein binds to Water]"15882959
D014867WaterCTRB1 protein binds to Water15882959
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of CTRB1 mRNA"22326570

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-NAS2917002  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0008236serine-type peptidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0007586digestion-IEA-  
GO:0009235cobalamin metabolic process-TAS-  
GO:0022617extracellular matrix disassembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis