Gene: SMYD1

150572
BOP|KMT3D|ZMYND18|ZMYND22
SET and MYND domain containing 1
protein-coding
2p11.2
Ensembl:ENSG00000115593 MIM:606846 Vega:OTTHUMG00000155045 UniprotKB:Q8NB12
NC_000002.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.822e-1 (AD)  4.690e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2970888chr2:88112274 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2970911chr2:88096305 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
THEMIS0.857
SH2D1B0.793
HS3ST40.761
ISLR0.758
HS3ST20.753
NPFFR20.742
SEMA3E0.73
GALNT140.73
GRIK30.728
PDZRN40.725

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR2F2-0.453
NDNF-0.449
RXRG-0.446
MSX2-0.429
MSX1-0.407
SPRY1-0.407
TSPAN12-0.406
C4orf19-0.396
CXCL14-0.396
CCDC88C-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SMYD1 mRNA"25510870
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of SMYD1 mRNA"18343893
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SMYD1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SMYD1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SMYD1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SMYD1 mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of SMYD1 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SMYD1 mRNA21298039
D004958EstradiolEstradiol promotes the reaction [SMYD1 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in decreased expression of SMYD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SMYD1 gene28505145
D002509CephaloridineCephaloridine results in increased expression of SMYD1 mRNA18500788
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SMYD1 mRNA23914054
D019422Dietary SucroseDietary Sucrose results in increased expression of SMYD1 mRNA26033743
D004318DoxycyclineDoxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA]18089841
C024565ethylene dichlorideethylene dichloride results in decreased expression of SMYD1 mRNA28189721
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of SMYD1 mRNA19376150
D007545IsoproterenolDoxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA]18089841
D007545IsoproterenolIsoproterenol results in decreased expression of SMYD1 mRNA18089841|2000320
D008713MethimazoleMethimazole results in increased expression of SMYD1 mRNA22504374
D009151Mustard GasMustard Gas results in increased expression of SMYD1 mRNA26392148
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SMYD1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SMYD1 mRNA22237054
C006253pirinixic acidpirinixic acid results in increased expression of SMYD1 mRNA18301758
C045950propiconazolepropiconazole results in increased expression of SMYD1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of SMYD1 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of SMYD1 mRNA22504374
D013096SpermineSpermine results in increased expression of SMYD1 mRNA18673383
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMYD1 mRNA18343893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SMYD1 mRNA19770486
D013792ThalidomideThalidomide results in decreased expression of SMYD1 mRNA26006729|2621778
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SMYD1 mRNA18087596
D014635Valproic AcidValproic Acid results in increased expression of SMYD1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of SMYD1 mRNA15799026
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SMYD1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003714transcription corepressor activity-IEA-  
GO:0005515protein binding-IPI23455924  25416956  
GO:0018024histone-lysine N-methyltransferase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006338chromatin remodeling-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007507heart development-IEA-  
GO:0010831positive regulation of myotube differentiation-IDA19783823  
GO:0034968histone lysine methylation-IEA-  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:0045663positive regulation of myoblast differentiation-IDA19783823  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal