Gene: CTRL

1506
CTRL1
chymotrypsin like
protein-coding
16q22.1
Ensembl:ENSG00000141086 MIM:118888 Vega:OTTHUMG00000137552 UniprotKB:P40313
NG_051639.1
PubMed
0   ANCO-SNPs
CD|ND|AD
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.913e-1 (AD)  3.569e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSEN540.748
FAM193B0.744
PRR140.719
DOT1L0.713
NCKAP5L0.706
LIME10.698
CRYGS0.693
LRCH40.693
NOP20.688
TRABD0.688

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.379
OR4F29-0.339
SCN7A-0.228
PAGE4-0.227
COL25A1-0.224
PARPBP-0.214
DEPDC4-0.204
C22orf42-0.196
SPANXN3-0.196
NTS-0.195

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CTRL mRNA16483693
D001280AtrazineAtrazine results in increased expression of CTRL mRNA18522720
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CTRL mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of CTRL mRNA26364221
C006780bisphenol Abisphenol A affects the expression of CTRL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CTRL mRNA25181051
D002922CiguatoxinsCiguatoxins affects the expression of CTRL mRNA18353800
D003024ClozapineClozapine results in increased expression of CTRL mRNA16715494
D003042CocaineCocaine affects the expression of CTRL mRNA20187946
D003042CocaineCocaine results in increased expression of CTRL mRNA27899881
D003300CopperCopper results in increased expression of CTRL mRNA24403277
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CTRL mRNA20971185
D003300CopperCopper results in increased expression of CTRL mRNA18522721
D004147DioxinsDioxins affects the expression of CTRL mRNA20463971
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of CTRL mRNA16206274
D006220HaloperidolHaloperidol results in increased expression of CTRL mRNA16715494
C008261lead acetatelead acetate results in increased expression of CTRL mRNA20542052
D008694MethamphetamineMethamphetamine results in increased expression of CTRL mRNA19564919
D008727MethotrexateMethotrexate results in decreased expression of CTRL mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CTRL mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CTRL mRNA"25620056
D009532NickelNickel results in increased expression of CTRL mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CTRL mRNA20971185
D010634PhenobarbitalPhenobarbital affects the expression of CTRL mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of CTRL mRNA17426115
D011794QuercetinQuercetin results in increased expression of CTRL mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of CTRL mRNA21515302
C459379SCH 351591SCH 351591 results in increased expression of CTRL mRNA20585143
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CTRL mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of CTRL mRNA22561333
D013629TamoxifenTamoxifen results in decreased expression of CTRL mRNA15590111
C501413tesaglitazartesaglitazar results in increased expression of CTRL mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTRL mRNA21570461
D013806TheophyllineTheophylline results in increased expression of CTRL mRNA18951874
C009495titanium dioxidetitanium dioxide results in increased expression of CTRL mRNA23409001
C057693troglitazonetroglitazone results in increased expression of CTRL mRNA21515302
D014501UraniumUranium affects the expression of CTRL mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of CTRL mRNA15672453
D014520UrethaneUrethane results in decreased expression of CTRL mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of CTRL gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0008236serine-type peptidase activity-IDA9065485  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0030163protein catabolic process-IC9065485  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA9065485  
KEGG ID KEGG Term
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27335431Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. (2016 Jun)Aizawa KPhysiol Rep
29708388Does exercise aid smoking cessation through reductions in anxiety sensitivity and dysphoria? (2018 Apr 30)Zvolensky MJHealth Psychol
12486509Effect of smoking on tear proteins. (2002 Nov)Grus FHGraefes Arch Clin Exp Ophthalmol
27610652Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking. (2016 Dec)Gortz GEJ Clin Endocrinol Metab
16171435Bone filling around titanium implants may benefit from smoking cessation: a histologic study in rats. (2005 Sep)Cesar-Neto JBJ Periodontol
23148822The efficacy of vigorous-intensity exercise as an aid to smoking cessation in adults with elevated anxiety sensitivity: study protocol for a randomized controlled trial. (2012 Nov 13)Smits JATrials
21881571Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence. (2011 Dec)Kufahl PRNeuropsychopharmacology
10581411Dopamine transporter mRNA in autopsy studies of chronic cocaine users. (1999 Nov 10)Chen LBrain Res Mol Brain Res
21171527Effect of Ramadan fasting on tear proteins. (2010)Sariri RActa Medica (Hradec Kralove)
20020508Human cleft lip and palate fibroblasts and normal nicotine-treated fibroblasts show altered in vitro expressions of genes related to molecular signaling pathways and extracellular matrix metabolism. (2010 Mar)Baroni TJ Cell Physiol
29404434Gut microbial composition can differentially regulate bile acid synthesis in humanized mice. (2017 Feb)Kang DJHepatol Commun
27621224The relationship between sleep apnea, metabolic dysfunction and inflammation: The gender influence. (2017 Jan)Hirotsu CBrain Behav Immun
26513517The Efficacy of Vigorous-Intensity Exercise as an Aid to Smoking Cessation in Adults With High Anxiety Sensitivity: A Randomized Controlled Trial. (2016 Apr)Smits JAPsychosom Med
9587889Eating behavior and pregnancy outcome. (1998 Mar-Apr)Conti JJ Psychosom Res