Gene: FAM117B

150864
ALS2CR13
family with sequence similarity 117 member B
protein-coding
2q33.2
Ensembl:ENSG00000138439 Vega:OTTHUMG00000154550 UniprotKB:Q6P1L5
NC_000002.12
SNP Mapped
9   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.642e-1 (AD)  8.001e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11685819chr2:202764034 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2351117chr2:202762689 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2351116chr2:202762588 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6435163chr2:202744019 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7581854chr2:202742031 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7602496chr2:202737484 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7571219chr2:202718531 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6709463chr2:202680475 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs28760505chr2:202671092 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MLLT30.911
ATF20.893
EFCAB70.891
HOOK10.884
ZBTB110.884
RHOT10.882
PLEKHA10.879
TRIM230.878
UBE2W0.878
FBXO280.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.44
FZD10-0.433
OR4F29-0.411
CD248-0.402
CSAG1-0.398
COX4I2-0.397
ALDH3B1-0.391
ASB4-0.377
AQP5-0.375
COPZ2-0.373

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of FAM117B mRNA"21724226
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of FAM117B mRNA"21724226
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM117B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM117B mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of FAM117B mRNA28959563
D001151ArsenicArsenic affects the expression of FAM117B mRNA18414638
C006632arsenic trioxidearsenic trioxide results in increased expression of FAM117B mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAM117B mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM117B mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FAM117B mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of FAM117B mRNA25181051
D016572CyclosporineCyclosporine results in decreased expression of FAM117B mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of FAM117B mRNA19770486
D002945CisplatinCisplatin results in decreased expression of FAM117B mRNA27594783
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FAM117B mRNA23649840
D005485FlutamideFlutamide results in decreased expression of FAM117B mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of FAM117B mRNA23649840
D005897GlafenineGlafenine results in decreased expression of FAM117B mRNA24136188
D017313FenretinideFenretinide results in decreased expression of FAM117B mRNA28973697
D007501IronIron deficiency results in increased expression of FAM117B mRNA16629162
D007545IsoproterenolIsoproterenol results in increased expression of FAM117B mRNA20003209
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FAM117B mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FAM117B mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAM117B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAM117B mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of FAM117B mRNA24136188
C029938nickel sulfatenickel sulfate results in increased expression of FAM117B mRNA22714537
D010100OxygenOxygen deficiency results in increased expression of FAM117B mRNA26516004
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM117B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FAM117B mRNA26272509
D011794QuercetinQuercetin results in decreased expression of FAM117B mRNA21632981
D012834SilverSilver results in decreased expression of FAM117B mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM117B mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM117B mRNA21215274|2172422
D014520UrethaneUrethane results in increased expression of FAM117B mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of FAM117B mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of FAM117B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FAM117B mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of FAM117B gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  26496610  27173435  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal