Gene info: ID 1509

Gene: CTSD

GENE ID: 1509

Synonyms: CLN10|CPSD|HEL-S-130P

Description: cathepsin D

Gene type: protein-coding

Location: 11p15.5

dbXrefs: Ensembl:ENSG00000117984 MIM:116840 Vega:OTTHUMG00000044760 UniprotKB:P07339

RefSeq: NG_008655.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.044e-1 (AD) 8.549e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YIPF3	0.949
WBP2	0.945
SCAMP3	0.942
GRINA	0.942
TUFM	0.94
MRPL38	0.94
GPS1	0.937
RAB11B	0.935
BCAP31	0.934
PSAP	0.933

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.833
OR4F29	-0.801
CEACAM3	-0.295
KLRB1	-0.292
DPPA4	-0.288
FCRL1	-0.283
GADL1	-0.28
BMP15	-0.27
IL2RB	-0.27
KCNJ15	-0.269

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00030	Insulin Human	BiotechDrug	11061-68-0	Approved\|Investigational	Target
DB00071	Insulin Pork	BiotechDrug	12584-58-6	Approved	Target
DB02216	S-Methylcysteine	Small Molecule	1187-84-4	Experimental	Target
DB03028	1h-Benoximidazole-2-Carboxylic Acid	Small Molecule		Experimental	Target
DB03096	N-Aminoethylmorpholine	Small Molecule		Experimental	Target
DB07542	5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID	Small Molecule		Experimental	Target
DB08740	CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C026702	16-hydroxyestrone	16-hydroxyestrone results in increased expression of CTSD	10030690
C557531	1,7-diphenyl-5-heptene-3-one	"1,7-diphenyl-5-heptene-3-one results in increased expression of CTSD mRNA"	19654927
C557531	1,7-diphenyl-5-heptene-3-one	"fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of CTSD mRNA]"	19654927
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CTSD mRNA"	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CTSD mRNA"	19114083
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTSD protein"	20951759
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CTSD mRNA"	12097258
C001390	2-hydroxyestradiol	2-hydroxyestradiol inhibits the reaction [Estradiol results in increased expression of CTSD]	10030690
C024980	2-hydroxyestrone	2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CTSD]	10030690
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of CTSD mRNA	15890375
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CTSD protein]"	28844962
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CTSD protein]"	28844962
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CTSD protein]"	28844962
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in increased expression of CTSD mRNA"	16192472
C557505	3',4'-dimethoxy-alpha-naphthoflavone	"3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]"	22235307
C010118	4,4'-dihydroxystilbene	"4,4'-dihydroxystilbene results in increased expression of CTSD mRNA"	19496085
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of CTSD mRNA"	24349450
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTSD mRNA"	27188386
C064297	4-hydroxystilbene	4-hydroxystilbene results in increased expression of CTSD mRNA	19496085
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTSD mRNA	15890375
C041594	4-nonylphenol	4-nonylphenol results in increased expression of CTSD protein	26804032
C041594	4-nonylphenol	4-nonylphenol results in increased expression of CTSD mRNA	12470818
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of CTSD mRNA	23219593
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of CTSD protein	23219593
C105260	4-tert-octylphenol	ESR1 mutant form inhibits the reaction [4-tert-octylphenol results in increased expression of CTSD mRNA]	23219593
C105260	4-tert-octylphenol	fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CTSD mRNA]	23219593
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTSD mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of CTSD mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of CTSD protein	8794998
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CTSD mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CTSD mRNA	15890375
C412373	AG 1879	AG 1879 results in increased expression of CTSD protein	23864846
C412373	AG 1879	arsenic trioxide promotes the reaction [AG 1879 results in increased expression of CTSD protein]	23864846
C412373	AG 1879	Tretinoin promotes the reaction [AG 1879 results in increased expression of CTSD protein]	23864846
C006453	alliin	alliin affects the reaction [Isoproterenol affects the activity of CTSD protein]	17623887
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]	11165043
D024502	alpha-Tocopherol	alpha-Tocopherol results in increased expression of CTSD protein	18942769
D017311	Amlodipine	[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]	14499179
D017311	Amlodipine	[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	11829124\|1449917
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CTSD mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in increased expression of CTSD protein	16483693
D000655	Amodiaquine	Amodiaquine results in decreased activity of CTSD protein	24113242
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of CTSD mRNA	12558987
D000872	Anthocyanins	Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]	25451569
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CTSD mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CTSD mRNA	23912714
D001151	Arsenic	Arsenic results in decreased expression of CTSD protein	25110733
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [AG 1879 results in increased expression of CTSD protein]	23864846
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CTSD protein	23864846\|2541905
D001205	Ascorbic Acid	[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	17045618
C406592	azaspiracid	azaspiracid results in decreased metabolism of CTSD protein	23387425
C037689	benzamide	benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]	17157789
C037689	benzamide	benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]	17157789
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CTSD mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of CTSD mRNA	21632023
D001564	Benzo(a)pyrene	Benzo(a)pyrene analog results in increased expression of CTSD mRNA	19365803
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CTSD mRNA	17879257
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CTSD mRNA	19365803
D001564	Benzo(a)pyrene	fulvestrant inhibits the reaction [Benzo(a)pyrene analog results in increased expression of CTSD mRNA]	19365803
D001564	Benzo(a)pyrene	fulvestrant inhibits the reaction [Benzo(a)pyrene results in increased expression of CTSD mRNA]	19365803
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CTSD mRNA	21715664\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CTSD mRNA"	20382639
D004958	Estradiol	"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CTSD protein]"	28844962
D004958	Estradiol	"3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]"	22235307
D004958	Estradiol	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]	11165043
D004958	Estradiol	ARNT protein affects the reaction [Estradiol results in increased expression of CTSD mRNA]	22235307
D004958	Estradiol	benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]	17157789
D004958	Estradiol	EGF protein promotes the reaction [Estradiol results in increased expression of CTSD mRNA]	24758408
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNA	19619570
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased secretion of CTSD protein	7909315
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]	17157789\|1969876
D004958	Estradiol	Estradiol promotes the reaction [[ESR1 protein binds to CTSD promoter] which results in increased expression of CTSD mRNA]	11165043\|1116504
D004958	Estradiol	Estradiol promotes the reaction [NCOA1 protein binds to CTSD promoter]	27366082
D004958	Estradiol	[Estradiol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA	22403704
D004958	Estradiol	Estradiol results in increased expression of CTSD mRNA	10376965\|1041129
D004958	Estradiol	Estradiol results in increased expression of CTSD protein	22235307\|2321959
D004958	Estradiol	[Estradiol results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA	24586459
D004958	Estradiol	Estradiol results in increased secretion of CTSD protein	2278856\|7498097\|
D004958	Estradiol	Estradiol results in increased secretion of CTSD protein modified form	2278856
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	19365803\|1965492
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD protein]	26344002\|2640794
D004958	Estradiol	Genistein inhibits the reaction [Estradiol results in increased expression of CTSD protein]	26407941
D004958	Estradiol	Quercetin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	10376965
D004958	Estradiol	[Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	11165043
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	11165043\|1117968
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein]	22235307\|8524236
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein]	2278856\|8384872\|
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein modified form]	2278856
D004958	Estradiol	[Dieldrin co-treated with Estradiol] results in decreased expression of CTSD mRNA	23041725
D004958	Estradiol	Estradiol results in increased expression of CTSD mRNA	12470818
D004958	Estradiol	Estradiol results in increased expression of CTSD mRNA	16192472\|1782345
D004958	Estradiol	2-hydroxyestradiol inhibits the reaction [Estradiol results in increased expression of CTSD]	10030690
D004958	Estradiol	2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CTSD]	10030690
D004958	Estradiol	Estradiol results in increased expression of CTSD	10030690
C006780	bisphenol A	bisphenol A affects the expression of CTSD mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of CTSD mRNA	26364221
C006780	bisphenol A	"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CTSD protein]"	28844962
C006780	bisphenol A	bisphenol A promotes the reaction [ESR1 protein binds to CTSD promoter]	27366082
C006780	bisphenol A	bisphenol A promotes the reaction [NCOA1 protein binds to CTSD promoter]	27366082
C006780	bisphenol A	[bisphenol A results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA	14754635\|2240370
C006780	bisphenol A	bisphenol A results in increased expression of CTSD mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of CTSD protein	26407941\|2884496
C006780	bisphenol A	[bisphenol A results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA	24586459
C006780	bisphenol A	ESR1 protein promotes the reaction [bisphenol A promotes the reaction [ESR1 protein binds to CTSD promoter]]	27366082
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to CTSD promoter]]	27366082
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of CTSD protein]	26407941\|2884496
C006780	bisphenol A	Genistein inhibits the reaction [bisphenol A results in increased expression of CTSD protein]	26407941
C006780	bisphenol A	bisphenol A affects the expression of CTSD mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of CTSD mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of CTSD mRNA	20977926
C083806	brucine	brucine results in decreased expression of CTSD mRNA	23933019
C083806	brucine	brucine results in decreased expression of CTSD mRNA	23933019
C083806	brucine	brucine results in decreased expression of CTSD protein	23933019
D002065	Buspirone	Buspirone results in increased expression of CTSD mRNA	24136188
D002104	Cadmium	Cadmium results in increased expression of CTSD mRNA	8207012
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CTSD protein	16249038
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CTSD	22041583
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CTSD mRNA	20219890
D019256	Cadmium Chloride	Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD]	22041583
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CTSD mRNA	21297351
C040048	caffeic acid	caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]	20391626
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CTSD mRNA	27339419
C099555	CD 437	CD 437 results in increased localization of CTSD protein	11423908
D002738	Chloroquine	Chloroquine affects the localization of CTSD protein	7715800
D002738	Chloroquine	Chloroquine results in increased expression of CTSD protein	2759144
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA	20938992
D002927	Cimetidine	Cimetidine results in decreased activity of CTSD protein	12903910
D002994	Clofibrate	Clofibrate results in decreased expression of CTSD mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CTSD mRNA	19320972\|1937684
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CTSD mRNA	24386269
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CTSD protein	24386269
D003042	Cocaine	Cocaine affects the expression of CTSD mRNA	15681117
D003042	Cocaine	Cocaine results in increased expression of CTSD protein	25100957
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of CTSD mRNA	20971185
D003300	Copper	Copper affects the expression of CTSD protein	17192175
D004205	Cromolyn Sodium	[pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein	8812242
C029892	cupric chloride	cupric chloride results in decreased expression of CTSD protein	21641295
D003474	Curcumin	Curcumin analog results in decreased expression of CTSD mRNA	26409325
D003474	Curcumin	Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]	8534267
D003474	Curcumin	Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	8534267
D003520	Cyclophosphamide	[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNA	18433785
D003520	Cyclophosphamide	Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]	25451569
D003520	Cyclophosphamide	Cyclophosphamide results in increased activity of CTSD protein	25451569
D003520	Cyclophosphamide	Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]	25451569
D016572	Cyclosporine	Cyclosporine results in increased expression of CTSD mRNA	20106945
C093628	cyproconazole	cyproconazole results in increased expression of CTSD mRNA	22334560
C108338	cyprodinil	cyprodinil results in increased expression of CTSD protein	26344002
C108338	cyprodinil	fulvestrant inhibits the reaction [cyprodinil results in increased expression of CTSD protein]	26344002
D003543	Cysteamine	Cysteamine results in increased expression of CTSD protein	20165931
D003543	Cysteamine	Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]	20165931
D003543	Cysteamine	thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein]	20165931
D003634	DDT	[DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA	22403704
C036901	defibrotide	defibrotide results in decreased export of CTSD protein	3063971
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in increased expression of CTSD mRNA	17823450\|1870914
D013759	Dronabinol	Dronabinol results in increased expression of CTSD mRNA	18163980
D013759	Dronabinol	Dronabinol results in increased expression of CTSD protein	18163980
D003847	Deoxyglucose	Deoxyglucose results in increased expression of CTSD protein	20026095
D003907	Dexamethasone	Dexamethasone results in decreased expression of CTSD mRNA	25047013
D003907	Dexamethasone	Dexamethasone results in increased expression of CTSD mRNA	21041162
D036381	Diarylheptanoids	Diarylheptanoids results in increased expression of CTSD mRNA	19654927
D036381	Diarylheptanoids	fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of CTSD mRNA]	19654927
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CTSD mRNA	17379624
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of CTSD mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of CTSD mRNA	21151649
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of CTSD mRNA	12470818
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of CTSD mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of CTSD protein	28385952
D004026	Dieldrin	Dieldrin affects the expression of CTSD mRNA	23041725
D004026	Dieldrin	[Dieldrin co-treated with Estradiol] results in decreased expression of CTSD mRNA	23041725
D004041	Dietary Fats	Dietary Fats results in decreased expression of CTSD mRNA	18042831
D004041	Dietary Fats	"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CTSD mRNA"	12097258
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CTSD mRNA	15890375
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CTSD mRNA"	12097258
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CTSD mRNA	15890375
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of CTSD mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of CTSD mRNA	20463971
D004237	Diuron	Diuron results in decreased expression of CTSD mRNA	21551480
D004298	Dopamine	Dopamine results in increased expression of CTSD protein	24675778
D004317	Doxorubicin	CTSD protein results in decreased susceptibility to Doxorubicin	18566016
D004317	Doxorubicin	Doxorubicin results in increased expression of CTSD protein	18566016
D004317	Doxorubicin	Doxorubicin results in decreased activity of CTSD protein	12841641
D004317	Doxorubicin	Doxorubicin results in decreased expression of CTSD mRNA	19915844
D004317	Doxorubicin	Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein]	12841641
D004610	Ellagic Acid	Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	21762681
D004642	Emodin	Emodin results in decreased expression of CTSD mRNA	16045814
C044101	endotoxin, Escherichia coli	"endotoxin, Escherichia coli results in increased expression of CTSD mRNA"	15919760
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of CTSD mRNA	19118595
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein]	18294627
C109476	epoxiconazole	epoxiconazole results in increased expression of CTSD mRNA	22334560
D004964	Estriol	Estriol results in increased expression of CTSD	10030690
D004977	Ethambutol	Ethambutol results in increased expression of and affects the localization of CTSD protein	19063910
D004977	Ethambutol	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of and affects the localization of CTSD protein]"	19063910
D000431	Ethanol	Ethanol affects the expression of CTSD mRNA	24355176
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CTSD protein	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CTSD mRNA	23550701
D015025	Zearalenone	Zearalenone results in increased expression of CTSD mRNA	28965971
C540355	fenamidone	fenamidone results in increased expression of CTSD mRNA	27029645
C004999	ferulic acid	[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	17045618
D005419	Flavonoids	Flavonoids results in increased expression of CTSD mRNA	18035473
C108339	fludioxonil	fludioxonil results in increased expression of CTSD protein	27539251
C108339	fludioxonil	fulvestrant inhibits the reaction [fludioxonil results in increased expression of CTSD protein]	27539251
D005485	Flutamide	Flutamide results in increased expression of CTSD mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA	20938992
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased activity of CTSD protein	25698669
D005620	Freund's Adjuvant	[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased activity of CTSD protein]	25698669
D005620	Freund's Adjuvant	morin inhibits the reaction [Freund's Adjuvant results in increased activity of CTSD protein]	25698669
C070081	fulvestrant	"fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of CTSD mRNA]"	19654927
C070081	fulvestrant	fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CTSD mRNA]	23219593
C070081	fulvestrant	fulvestrant inhibits the reaction [Benzo(a)pyrene analog results in increased expression of CTSD mRNA]	19365803
C070081	fulvestrant	fulvestrant inhibits the reaction [Benzo(a)pyrene results in increased expression of CTSD mRNA]	19365803
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to CTSD promoter]]	27366082
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of CTSD protein]	26407941\|2884496
C070081	fulvestrant	fulvestrant inhibits the reaction [cyprodinil results in increased expression of CTSD protein]	26344002
C070081	fulvestrant	fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of CTSD mRNA]	19654927
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	19365803\|1965492
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD protein]	26344002\|2640794
C070081	fulvestrant	fulvestrant inhibits the reaction [fludioxonil results in increased expression of CTSD protein]	27539251
C070081	fulvestrant	"fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CTSD protein]"	26344002
C070081	fulvestrant	fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]	27366082
C070081	fulvestrant	fulvestrant inhibits the reaction [nonylphenol results in increased expression of CTSD protein]	26407941
C070081	fulvestrant	fulvestrant inhibits the reaction [Triclosan results in increased expression of CTSD protein]	28844962
C070081	fulvestrant	fulvestrant results in decreased expression of CTSD mRNA	14750165
C070081	fulvestrant	fulvestrant results in increased expression of CTSD mRNA	15072547
C056933	fumonisin B1	fumonisin B1 results in increased expression of CTSD mRNA	16221962
D019833	Genistein	Genistein inhibits the reaction [bisphenol A results in increased expression of CTSD protein]	26407941
D019833	Genistein	Genistein inhibits the reaction [Estradiol results in increased expression of CTSD protein]	26407941
D019833	Genistein	Genistein inhibits the reaction [nonylphenol results in increased expression of CTSD protein]	26407941
D019833	Genistein	Genistein results in increased expression of CTSD mRNA	10376965\|1509053
D019833	Genistein	Quercetin inhibits the reaction [Genistein results in increased expression of CTSD mRNA]	10376965
D019833	Genistein	Genistein results in decreased expression of CTSD mRNA	21048042
D005839	Gentamicins	Gentamicins results in increased expression of CTSD mRNA	22061828
D005944	Glucosamine	Glucosamine affects the localization of CTSD protein	15972124
D005944	Glucosamine	Glucosamine results in decreased expression of CTSD protein alternative form	16850161
D005944	Glucosamine	Glucosamine results in increased activity of CTSD protein	16850161
D005944	Glucosamine	pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form]	16850161
C500810	GW8510	GW8510 results in increased expression of CTSD mRNA	22242153
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CTSD protein	21179406
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of CTSD mRNA	15072547
D007052	Ibuprofen	Ibuprofen results in increased expression of CTSD mRNA	28201806
C016517	indole-3-carbinol	indole-3-carbinol results in decreased expression of CTSD protein	11110848
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of CTSD mRNA	16192472
D007213	Indomethacin	[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased activity of CTSD protein]	25698669
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTSD mRNA	25613284
D007545	Isoproterenol	alliin affects the reaction [Isoproterenol affects the activity of CTSD protein]	17623887
D007545	Isoproterenol	caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]	20391626
D007545	Isoproterenol	Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]	8534267
D007545	Isoproterenol	Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	8534267
D007545	Isoproterenol	Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	21762681
D007545	Isoproterenol	epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein]	18294627
D007545	Isoproterenol	[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	17045618
D007545	Isoproterenol	Isoproterenol affects the activity of CTSD protein	17623887\|1829462
D007545	Isoproterenol	Isoproterenol results in decreased activity of CTSD protein	14499179\|1917258
D007545	Isoproterenol	Isoproterenol results in increased activity of CTSD protein	11829124\|1449917
D007545	Isoproterenol	Isoproterenol results in increased expression of CTSD mRNA	17182065\|894732
D007545	Isoproterenol	Isoproterenol results in increased expression of CTSD protein	18424012
D007545	Isoproterenol	mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]	19172585
D007545	Isoproterenol	Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA]	894732
D007545	Isoproterenol	naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	17188415
D007545	Isoproterenol	[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]	14499179
D007545	Isoproterenol	[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	11829124\|1449917
D007545	Isoproterenol	Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	19641666
D007545	Isoproterenol	S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA]	17182065
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of CTSD mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of CTSD mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of CTSD protein	17337753
D007854	Lead	Lead affects the expression of CTSD mRNA	28903495
C045463	leflunomide	leflunomide results in increased expression of CTSD mRNA	24136188
C018584	linalool	linalool results in increased expression of CTSD mRNA	19922762
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CTSD mRNA	15919760
D008094	Lithium	Lithium results in increased expression of CTSD protein	18296634
D008154	Lucanthone	Lucanthone results in increased expression of CTSD mRNA	21148553
D008154	Lucanthone	Lucanthone results in increased expression of CTSD protein	21148553
D008294	Malathion	Malathion results in increased expression of CTSD protein	8812242
C025340	manganese chloride	manganese chloride affects the localization of CTSD protein	28378122
C025340	manganese chloride	manganese chloride results in increased expression of CTSD protein	28378122
C013592	mangiferin	mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]	19172585
D008464	Mecamylamine	[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNA	18433785
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of CTSD mRNA	18497975
D008550	Melatonin	Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD]	22041583
D008694	Methamphetamine	Methamphetamine affects the localization of CTSD protein	17105920
D008701	Methapyrilene	Methapyrilene results in increased expression of CTSD mRNA	15890375
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CTSD mRNA	16257430
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CTSD mRNA	23458150
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of CTSD protein	26558463
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of CTSD mRNA	16966085
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CTSD mRNA"	20188158
D008775	Methylprednisolone	Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA]	894732
D015741	Metribolone	Metribolone results in decreased expression of CTSD protein	17152098
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of CTSD mRNA	26924002
C008548	morin	[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased activity of CTSD protein]	25698669
C008548	morin	morin inhibits the reaction [Freund's Adjuvant results in increased activity of CTSD protein]	25698669
C568376	MT19c compound	MT19c compound results in decreased expression of CTSD mRNA	21781307
C451426	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	"fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CTSD protein]"	26344002
C451426	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CTSD protein"	26344002
C064769	N-acetylsphingosine	N-acetylsphingosine results in increased secretion of CTSD protein	15040013
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of CTSD mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CTSD mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CTSD mRNA"	25554681
D009281	Naphthalenes	Naphthalenes results in decreased expression of CTSD protein	17337753
C005273	naringenin	[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA	24586459
C005274	naringin	naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	17188415
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of CTSD mRNA	19812364
C051752	nefazodone	nefazodone results in increased expression of CTSD mRNA	24136188
C028007	nickel monoxide	nickel monoxide results in increased expression of CTSD mRNA	19167457
D020108	Nicorandil	[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]	14499179
D020108	Nicorandil	[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	11829124\|1449917
D009569	Nitric Oxide	Nitric Oxide results in increased secretion of CTSD protein	15040013
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of CTSD mRNA	12102619
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of CTSD mRNA	17616710
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of and affects the localization of CTSD protein]"	19063910
C025256	nonylphenol	ESR1 protein promotes the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]	27366082
C025256	nonylphenol	fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]	27366082
C025256	nonylphenol	fulvestrant inhibits the reaction [nonylphenol results in increased expression of CTSD protein]	26407941
C025256	nonylphenol	Genistein inhibits the reaction [nonylphenol results in increased expression of CTSD protein]	26407941
C025256	nonylphenol	nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]	27366082
C025256	nonylphenol	nonylphenol promotes the reaction [NCOA1 protein binds to CTSD promoter]	27366082
C025256	nonylphenol	[nonylphenol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA	14754635
C025256	nonylphenol	nonylphenol results in increased expression of CTSD protein	26407941
C025256	nonylphenol	nonylphenol results in increased expression of CTSD mRNA	22982499
D004963	Estrenes	Estrenes analog results in increased expression of CTSD mRNA	15219790
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of CTSD mRNA	20971185
D009853	Omeprazole	Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]	20165931
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of CTSD mRNA"	22609851
D000073878	Palm Oil	Palm Oil results in decreased expression of CTSD mRNA	18042831
D010269	Paraquat	Paraquat results in decreased expression of CTSD mRNA	16797015
C031375	pepstatin	pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form]	16850161
C031375	pepstatin	pepstatin results in decreased activity of CTSD protein	11423908
C031375	pepstatin	pepstatin results in decreased activity of CTSD protein	6497855
C031375	pepstatin	pepstatin results in decreased activity of CTSD protein	17116725
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased expression of CTSD mRNA	21984479
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of CTSD mRNA	21984479
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CTSD mRNA	18709148\|2198447
D010615	Phenacetin	Phenacetin results in increased expression of CTSD mRNA	17698508
D010634	Phenobarbital	Phenobarbital results in increased expression of CTSD mRNA	19162173
C030299	phenylhydrazine	phenylhydrazine results in increased expression of CTSD mRNA	17698508
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTSD mRNA"	27188386
D010862	Pilocarpine	Pilocarpine results in increased expression of CTSD mRNA	17971868
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of CTSD mRNA	15890375\|2248451
C014153	pirimiphos methyl	pirimiphos methyl results in decreased activity of CTSD protein	9204212
C014153	pirimiphos methyl	pirimiphos methyl results in increased activity of CTSD protein	9204212
C006253	pirinixic acid	pirinixic acid results in increased expression of CTSD mRNA	18301758\|2081375
C006253	pirinixic acid	pirinixic acid results in increased expression of CTSD mRNA	15890375\|1916217
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]	25451569
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]	19641666
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CTSD mRNA	19162173
C009042	pristane	[pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein	8812242
C009042	pristane	pristane results in increased expression of CTSD protein	8812242
D011374	Progesterone	Progesterone results in increased expression of CTSD mRNA	18497975
C045950	propiconazole	propiconazole results in increased expression of CTSD mRNA	22334560
C010313	pseudocumene	pseudocumene results in decreased expression of CTSD protein	17337753
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased activity of CTSD protein	6497855
C010423	pyrithione zinc	pyrithione zinc results in increased expression of CTSD protein	20151177
D011794	Quercetin	Quercetin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	10376965
D011794	Quercetin	Quercetin inhibits the reaction [Genistein results in increased expression of CTSD mRNA]	10376965
D011794	Quercetin	Quercetin results in increased expression of CTSD mRNA	15090535\|2163298
C059514	resveratrol	CTSD protein affects the reaction [resveratrol affects the localization of CYCS protein]	17116725
C059514	resveratrol	CTSD protein affects the reaction [resveratrol promotes the reaction [BAX protein binds to BAX protein]]	17116725
C059514	resveratrol	CTSD protein affects the reaction [resveratrol results in increased activity of CASP3 protein]	17116725
C059514	resveratrol	CTSD protein affects the susceptibility to resveratrol	17116725
C059514	resveratrol	ESR1 protein affects the reaction [resveratrol affects the secretion of CTSD protein]	16393696
C059514	resveratrol	resveratrol affects the expression of CTSD mRNA	16393696
C059514	resveratrol	resveratrol metabolite results in increased expression of CTSD mRNA	19496085
C059514	resveratrol	resveratrol results in decreased expression of CTSD mRNA	14750165
C059514	resveratrol	resveratrol results in increased expression of and results in increased metabolism of and affects the localization of CTSD protein	17116725
C059514	resveratrol	resveratrol results in increased expression of CTSD	10402233
C059514	resveratrol	resveratrol results in increased expression of CTSD mRNA	20878097
C059514	resveratrol	resveratrol results in increased expression of CTSD protein	18089832
C059514	resveratrol	[resveratrol results in increased expression of IGF2 protein] which results in increased secretion of CTSD protein	16393696
C059514	resveratrol	resveratrol results in increased secretion of CTSD protein	16393696
C059514	resveratrol	resveratrol results in increased expression of CTSD mRNA	16081268
C009166	retinol acetate	retinol acetate results in increased expression of CTSD mRNA	16772331
D012402	Rotenone	Rotenone affects the expression of CTSD mRNA	23186747
C065299	S-allylcysteine	S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA]	17182065
D012524	Sarin	Sarin results in decreased expression of CTSD mRNA	19522546
C410733	scriptaid	scriptaid affects the expression of CTSD mRNA	18813790
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of CTSD protein	25895662
C009277	sodium arsenate	sodium arsenate results in increased expression of CTSD mRNA	16882884
C017947	sodium arsenite	sodium arsenite results in increased activity of CTSD protein	20816728
C017947	sodium arsenite	sodium arsenite results in increased expression of CTSD mRNA	20816728
C017947	sodium arsenite	sodium arsenite results in increased expression of CTSD protein	20050688
C016104	sodium bichromate	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of CTSD mRNA	21632023
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CTSD protein	28918527
D012999	Soman	Soman results in increased expression of CTSD mRNA	19281266
D053260	Soot	Soot results in increased expression of CTSD mRNA	22461453\|2655175
C061133	tamibarotene	tamibarotene results in increased expression of CTSD mRNA	15498508
D013629	Tamoxifen	benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]	17157789
D013629	Tamoxifen	Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]	17157789
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA]]	11165043
D013749	Tetrachlorodibenzodioxin	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]	11165043
D013749	Tetrachlorodibenzodioxin	ARNT protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA]]	11165043
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNA	19619570
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased secretion of CTSD protein	7909315
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	11165043
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]	11165043\|1117968
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein]	22235307\|8524236
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein]	2278856\|8384872\|
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein modified form]	2278856
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CTSD promoter]	11165043
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in decreased expression of CTSD mRNA]	11165043
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CTSD mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased secretion of CTSD protein	7909315
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CTSD mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA	11879969
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTSD mRNA	25613284
C042172	thallium nitrate	thallium nitrate affects the localization of CTSD protein	22669516
C042172	thallium nitrate	thallium nitrate analog affects the localization of CTSD protein	22669516
C042172	thallium nitrate	thallium nitrate analog results in increased activity of CTSD protein	22669516
C042172	thallium nitrate	thallium nitrate results in increased activity of CTSD protein	22669516
C549498	thamira parpam	thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein]	20165931
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein]	12841641
C009495	titanium dioxide	titanium dioxide results in decreased expression of CTSD mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of CTSD mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CTSD protein	27087172
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CTSD mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CTSD protein	27818348
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD protein	10772776
D014212	Tretinoin	Tretinoin promotes the reaction [AG 1879 results in increased expression of CTSD protein]	23864846
D014212	Tretinoin	Tretinoin results in increased expression of CTSD mRNA	15498508\|1605412
D014212	Tretinoin	Tretinoin results in increased expression of CTSD protein	23864846
D014260	Triclosan	"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CTSD protein]"	28844962
D014260	Triclosan	fulvestrant inhibits the reaction [Triclosan results in increased expression of CTSD protein]	28844962
D014260	Triclosan	Triclosan results in increased expression of CTSD protein	28844962
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased activity of CTSD protein	25855008
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of CTSD mRNA	25855008
D014415	Tunicamycin	Tunicamycin results in increased expression of CTSD mRNA	22378314
C406224	valdecoxib	valdecoxib results in increased expression of CTSD mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of CTSD mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CTSD mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased methylation of CTSD gene	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of CTSD mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CTSD gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of CTSD mRNA	22570695
C111237	vorinostat	vorinostat results in increased expression of CTSD protein	20543569
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of CTSD mRNA"	22326570

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004190	aspartic-type endopeptidase activity	-	IBA	21873635
GO:0004197	cysteine-type endopeptidase activity	-	TAS	-
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	17112520

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IBA	21873635
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	-
GO:0030574	collagen catabolic process	-	TAS	-
GO:0043312	neutrophil degranulation	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470 20551380
GO:0005615	extracellular space	-	ISS	22261194
GO:0005764	lysosome	-	IDA	1837142 19723497
GO:0035580	specific granule lumen	-	TAS	-
GO:0042470	melanosome	-	IEA	-
GO:0043202	lysosomal lumen	-	TAS	-
GO:0045121	membrane raft	-	IDA	25204797
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0070062	extracellular exosome	-	HDA	19056867 23533145
GO:1904724	tertiary granule lumen	-	TAS	-
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa04142	Lysosome

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	TAS
R-HSA-2132295	MHC class II antigen presentation	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27084846	Lung tissue proteomics identifies elevated transglutaminase 2 levels in stable chronic obstructive pulmonary disease. (2016 Jun 1)	Ohlmeier S	Am J Physiol Lung Cell Mol Physiol