Gene: PLB1

151056
PLB|PLB/LIP
phospholipase B1
protein-coding
2p23.2
Ensembl:ENSG00000163803 MIM:610179 Vega:OTTHUMG00000152014 UniprotKB:Q6P1J6
NG_051297.1
SNP Mapped
2   ANCO-SNPs
ND
0   
9.265e-1 (AD)  2.475e-1 (ND)   (Frontal_Cortex)
1.729e-1 (AD)  1.122e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6719289chr2:28633935 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs11127182chr2:28628249 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZC3H12D0.761
DIAPH20.736
C11orf450.725
MGAT4A0.72
PTBP30.719
PPM1N0.712
ARHGAP270.702
PLCB20.699
PTPN20.697
DNAH20.695

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PYGM-0.386
HPSE2-0.359
ASCL1-0.346
HES6-0.342
ZNF98-0.315
S100A1-0.303
HHATL-0.294
RNF182-0.29
SLC25A48-0.288
ENDOU-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PLB1 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PLB1 mRNA"23146750
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PLB1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLB1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PLB1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLB1 mRNA26001963
D004958EstradiolEstradiol results in increased expression of PLB1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of PLB1 mRNA25181051
D003300CopperCopper deficiency results in decreased expression of PLB1 mRNA19821111
D003300CopperCopper deficiency results in increased expression of PLB1 mRNA26033743
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of PLB1 mRNA26924002
D005419FlavonoidsFlavonoids results in increased expression of PLB1 mRNA18035473
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PLB1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLB1 mRNA26752646
C002385linsidominelinsidomine results in increased oxidation of PLB1 protein28086193
D015735MifepristoneMifepristone results in decreased expression of PLB1 mRNA25972201
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of PLB1 mRNA22401849
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PLB1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of PLB1 mRNA27760801
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PLB1 mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of PLB1 mRNA23527032
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PLB1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of PLB1 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004620phospholipase activity-IBA21873635  
GO:0004622lysophospholipase activity-IBA21873635  
GO:0004622lysophospholipase activity-IEA-  
GO:0004623phospholipase A2 activity-IBA21873635  
GO:0004623phospholipase A2 activity-TAS-  
GO:0050253retinyl-palmitate esterase activity-IBA21873635  
GO:0050253retinyl-palmitate esterase activity-TAS-  
GO:0102567phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)-IEA-  
GO:0102568phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0006644phospholipid metabolic process-IBA21873635  
GO:0016042lipid catabolic process-IEA-  
GO:0036151phosphatidylcholine acyl-chain remodeling-TAS-  
GO:0042572retinol metabolic process-IEA-  
GO:2000344positive regulation of acrosome reaction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0031526brush border membrane-IBA21873635  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
hsa00565Ether lipid metabolism
hsa00590Arachidonic acid metabolism
hsa00591Linoleic acid metabolism
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482788Acyl chain remodelling of PCTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal