Gene: PPP1R1C

151242
IPP5
protein phosphatase 1 regulatory inhibitor subunit 1C
protein-coding
2q31.3-q32.1
Ensembl:ENSG00000150722 MIM:613240 Vega:OTTHUMG00000154326 UniprotKB:Q8WVI7
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  3.783e-1 (ND)   (Frontal_Cortex)
8.191e-1 (AD)  8.107e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16822370chr2:182041984 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNMT0.567
SNX70.53
ULK20.513
RNF1800.513
KIF2A0.509
ZNF7040.501
LZIC0.499
ALCAM0.494
FBXL40.494
ZZZ30.488

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AHSP-0.275
HBM-0.274
ALAS2-0.256
CA1-0.255
JSRP1-0.249
PTGDR2-0.247
AZU1-0.245
CALML6-0.243
KLF1-0.236
PRSS38-0.234

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1C mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1C mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1C mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1C mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1C mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP1R1C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP1R1C mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PPP1R1C mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of PPP1R1C mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPP1R1C mRNA22100608
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPP1R1C mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PPP1R1C mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PPP1R1C mRNA12832660
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP1R1C mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PPP1R1C mRNA26272509
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of PPP1R1C mRNA26033743
D003300CopperCopper deficiency results in increased expression of PPP1R1C mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of PPP1R1C mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PPP1R1C mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPP1R1C mRNA28628672
D015946Ethylene DibromideEthylene Dibromide results in decreased expression of PPP1R1C mRNA15612046
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PPP1R1C mRNA27392435
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of PPP1R1C mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of PPP1R1C mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of PPP1R1C mRNA16002434
D004642EmodinEmodin results in decreased expression of PPP1R1C mRNA15612046
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of PPP1R1C mRNA25198161
D005485FlutamideFlutamide results in decreased expression of PPP1R1C mRNA21126777
D005557FormaldehydeFormaldehyde results in increased expression of PPP1R1C mRNA27664576
C069837fullerene C60fullerene C60 results in decreased expression of PPP1R1C mRNA19167457
C004312glycidolglycidol results in decreased expression of PPP1R1C mRNA15612046
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPP1R1C mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPP1R1C mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PPP1R1C mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PPP1R1C mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PPP1R1C mRNA26752646
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PPP1R1C mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PPP1R1C mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PPP1R1C mRNA24810058
D015735MifepristoneMifepristone results in increased expression of PPP1R1C mRNA17584828
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PPP1R1C mRNA12832660
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1C mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PPP1R1C mRNA23948077
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPP1R1C mRNA19710929
D015125OxyquinolineOxyquinoline results in decreased expression of PPP1R1C mRNA15612046
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PPP1R1C mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPP1R1C mRNA21570461
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PPP1R1C mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of PPP1R1C mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PPP1R1C gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PPP1R1C mRNA21126777
C025643vinclozolinvinclozolin results in increased expression of PPP1R1C mRNA23869203
C111237vorinostatvorinostat results in increased expression of PPP1R1C mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of PPP1R1C mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0032515negative regulation of phosphoprotein phosphatase activity-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal