Gene: UPP2

151531
UDRPASE2|UP2|UPASE2
uridine phosphorylase 2
protein-coding
2q24.1
Ensembl:ENSG00000007001 MIM:617340 Vega:OTTHUMG00000131969 UniprotKB:O95045
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.347e-1 (AD)  4.812e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7607379chr2:158071694 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TEF0.706
ELK10.702
PPIL60.687
SESN10.67
ZNF2730.67
PPM1K0.665
ZC3H80.66
PSD30.657
DAPK10.657
PKIA0.657

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.408
TBX21-0.393
KLRB1-0.378
FZD10-0.375
IL2RB-0.374
LCK-0.368
CD2-0.357
KLRF1-0.349
CCL5-0.348
OR4F5-0.348

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05041RP101Small Molecule-InvestigationalTarget
DB00544FluorouracilSmall Molecule51-21-8ApprovedEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of UPP2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of UPP2 mRNA"21354444
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UPP2 mRNA"28903501
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of UPP2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of UPP2 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of UPP2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of UPP2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of UPP2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UPP2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UPP2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UPP2 mRNA19770486
D001151ArsenicArsenic affects the methylation of UPP2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UPP2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UPP2 mRNA20440473
C006780bisphenol Abisphenol A affects the expression of UPP2 mRNA24534842
C006780bisphenol Abisphenol A results in increased expression of UPP2 mRNA27104808
C006780bisphenol Abisphenol A results in increased methylation of UPP2 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of UPP2 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the expression of UPP2 mRNA18804290
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of UPP2 mRNA]16221973
D000074262Canola OilCanola Oil metabolite results in decreased expression of UPP2 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of UPP2 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of UPP2 mRNA18804290
D002922CiguatoxinsCiguatoxins affects the expression of UPP2 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of UPP2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UPP2 mRNA]17585979
D003300CopperCopper results in decreased expression of UPP2 mRNA17205981
C057862cyanoginosin LRcyanoginosin LR results in increased expression of UPP2 mRNA17383702
D004008DiclofenacDiclofenac results in decreased expression of UPP2 mRNA26934552
D004147DioxinsDioxins affects the expression of UPP2 mRNA20463971
C024565ethylene dichlorideethylene dichloride results in decreased expression of UPP2 mRNA28189721
D005047EtoposideEtoposide results in increased expression of UPP2 mRNA25270620
C039281furanfuran results in increased expression of UPP2 mRNA26194646
D006046Gold[Gold co-treated with Polyethylene Glycols] results in increased expression of UPP2 mRNA19695318
C029424hydrazinehydrazine results in decreased expression of UPP2 mRNA15282401
C016517indole-3-carbinolindole-3-carbinol affects the expression of UPP2 mRNA21396975
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of UPP2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of UPP2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UPP2 mRNA"25620056
C464660obeticholic acidobeticholic acid results in increased expression of UPP2 mRNA27939613
D009966OrphenadrineOrphenadrine affects the expression of UPP2 mRNA23665939
D010416PentachlorophenolPentachlorophenol results in increased expression of UPP2 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of UPP2 mRNA18804290
D010634PhenobarbitalPhenobarbital affects the expression of UPP2 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of UPP2 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of UPP2 mRNA18445702
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in increased expression of UPP2 mRNA19695318
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UPP2 mRNA28903501
D011374ProgesteroneProgesterone affects the expression of UPP2 mRNA19690047
C031280pyrazolepyrazole results in decreased expression of UPP2 mRNA17945193
D012312RitodrineRitodrine results in increased expression of UPP2 mRNA23370008
C009277sodium arsenatesodium arsenate results in decreased expression of UPP2 mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UPP2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UPP2 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UPP2 mRNA19770486
D014241TrichloroethyleneTrichloroethylene results in decreased expression of UPP2 mRNA19448997
C012589trichostatin Atrichostatin A results in increased expression of UPP2 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased methylation of UPP2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of UPP2 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of UPP2 mRNA15901671
C025643vinclozolinvinclozolin results in decreased expression of UPP2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of UPP2 mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of UPP2 mRNA"24525044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004850uridine phosphorylase activity-EXP7488099  
GO:0004850uridine phosphorylase activity-IDA12849978  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0009116nucleoside metabolic process-NAS12849978  
GO:0009166nucleotide catabolic process-IEA-  
GO:0043097pyrimidine nucleoside salvage-TAS-  
GO:0044206UMP salvage-IEA-  
GO:0046108uridine metabolic process-NAS11278417  
GO:0046135pyrimidine nucleoside catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-NAS11278417  
GO:0005829cytosol-TAS-  
GO:0045098type III intermediate filament-IDA11278417  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-73614Pyrimidine salvageTAS
R-HSA-73621Pyrimidine catabolismTAS
R-HSA-8956319Nucleobase catabolismTAS
R-HSA-8956321Nucleotide salvageTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal