Gene: SGO1

151648
CAID|NY-BR-85|SGO|SGOL1
shugoshin 1
protein-coding
3p24.3
Ensembl:ENSG00000129810 MIM:609168 Vega:OTTHUMG00000130479 UniprotKB:Q5FBB7
NG_042062.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.172e-1 (AD)  1.192e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SGO1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SGO1 mRNA"22698814|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SGO1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SGO1 mRNA"23146750
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SGO1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SGO1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SGO1 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SGO1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SGO1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SGO1 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of SGO1 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGO1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SGO1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGO1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SGO1 mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SGO1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SGO1 mRNA]17585979
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of SGO1 mRNA"22863853
C547126AZM551248AZM551248 results in increased expression of SGO1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SGO1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SGO1 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SGO1 mRNA20504355|2071347
D004958EstradiolEstradiol results in increased expression of SGO1 mRNA19167446
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of SGO1 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of SGO1 mRNA25210133
C044887beta-methylcholinebeta-methylcholine affects the expression of SGO1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of SGO1 mRNA23146750
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SGO1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SGO1 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SGO1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SGO1 mRNA]17585979
D003033Coal TarCoal Tar results in decreased expression of SGO1 mRNA27858113
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SGO1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SGO1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of SGO1 mRNA19167446
D000069439DasatinibDasatinib results in decreased expression of SGO1 mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SGO1 mRNA21266533
D002117CalcitriolCalcitriol results in decreased expression of SGO1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SGO1 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SGO1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SGO1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SGO1 mRNA20938992
D017313FenretinideFenretinide results in increased expression of SGO1 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of SGO1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SGO1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of SGO1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SGO1 mRNA24796395
D008154LucanthoneLucanthone results in decreased expression of SGO1 mRNA21148553
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SGO1 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SGO1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SGO1 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SGO1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SGO1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SGO1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SGO1 mRNA19812364
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SGO1 mRNA25658374
D010126OzoneOzone results in increased expression of SGO1 mRNA25658374
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SGO1 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SGO1 mRNA23146750
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SGO1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of SGO1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SGO1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGO1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SGO1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SGO1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SGO1 mRNA17950772|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of SGO1 mRNA]17950772
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SGO1 mRNA22698814
C005556propionaldehydepropionaldehyde results in decreased expression of SGO1 mRNA26079696
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SGO1 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SGO1 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of SGO1 mRNA17998272
D053260SootSoot results in increased expression of SGO1 mRNA22461453|2655175
C075117squalestatin 1squalestatin 1 results in decreased expression of SGO1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of SGO1 mRNA27225895
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of SGO1 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of SGO1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SGO1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SGO1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SGO1 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SGO1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SGO1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of SGO1 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of SGO1 mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SGO1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SGO1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SGO1 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of SGO1 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SGO1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of SGO1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16541025  16580887  17621308  18331714  18716626  20562864  
20739936  21346195  23242214  25173175  28330616  
GO:0019900kinase binding-IDA18331714  
GO ID GO Term Qualifier Evidence PubMed
GO:0007059chromosome segregation-IDA16580887  
GO:0008608attachment of spindle microtubules to kinetochore-IDA17621308  
GO:0010457centriole-centriole cohesion-IDA18331714  
GO:0010457centriole-centriole cohesion-IMP18331714  
GO:0045132meiotic chromosome segregation-IMP18331714  
GO:0051301cell division-IEA-  
GO:0071962mitotic sister chromatid cohesion, centromeric-IMP24157919  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-IDA16682347  24055156  
GO:0000776kinetochore-IDA17617734  18331714  24157919  
GO:0000776kinetochorecolocalizes_withIDA16582621  17621308  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0000779condensed chromosome, centromeric region-IDA19465021  
GO:0000922spindle pole-IDA18331714  
GO:0005654nucleoplasm-IDA-  
GO:0005813centrosome-IDA18331714  24157919  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04114Oocyte meiosis
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27526110Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung. (2016 Aug 15)Yamada HYOncogenesis