Gene: MB21D2

151963
C3orf59
Mab-21 domain containing 2
protein-coding
3q29
Ensembl:ENSG00000180611 Vega:OTTHUMG00000155768 UniprotKB:Q8IYB1
NC_000003.12
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.184e-1 (AD)  8.032e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9869202chr3:192907401 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7643379chr3:192901594 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs3952738chr3:192896694 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4455277chr3:192896519 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAXC0.954
NEGR10.941
SYT130.94
EPHA40.938
PLCL20.937
FGF140.936
FRMPD40.936
HCN10.935
LNX10.934
AMPH0.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.558
CSAG1-0.533
REST-0.532
RAI14-0.528
RNF135-0.525
YES1-0.524
WWTR1-0.522
RAB13-0.517
CHST14-0.511
CMTM3-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MB21D2 mRNA"25614096
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MB21D2 mRNA"19167446
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MB21D2 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MB21D2 mRNA20106945|2180250
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MB21D2 mRNA"19150397|2038263
C006780bisphenol Abisphenol A results in increased expression of MB21D2 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of MB21D2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of MB21D2 mRNA25181051
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of MB21D2 mRNA20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of MB21D2 mRNA20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MB21D2 mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of MB21D2 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MB21D2 mRNA]20847119
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MB21D2 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of MB21D2 mRNA24386269
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MB21D2 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of MB21D2 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of MB21D2 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MB21D2 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MB21D2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MB21D2 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MB21D2 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased methylation of MB21D2 promoter25374375
D004237DiuronDiuron results in increased expression of MB21D2 mRNA21551480
C118739entinostatentinostat results in decreased expression of MB21D2 mRNA27188386
D017313FenretinideFenretinide results in increased expression of MB21D2 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MB21D2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MB21D2 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MB21D2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MB21D2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MB21D2 mRNA"25620056
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MB21D2 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased methylation of MB21D2 promoter25374375
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of MB21D2 mRNA20847119
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of MB21D2 mRNA20847119
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MB21D2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MB21D2 mRNA21215274
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of MB21D2 mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MB21D2 mRNA]20847119
D014635Valproic AcidValproic Acid affects the expression of MB21D2 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MB21D2 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of MB21D2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0044877protein-containing complex binding-IDA23209302  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal