Gene: PPP4R2

151987
PP4R2
protein phosphatase 4 regulatory subunit 2
protein-coding
3p13
Ensembl:ENSG00000163605 MIM:613822 Vega:OTTHUMG00000158816 UniprotKB:Q9NY27
NC_000003.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.630e-1 (AD)  7.743e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9824246chr3:73053574 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDS5A0.902
IKZF50.887
TBC1D150.878
MIER10.875
RYBP0.875
TBC1D230.872
SLC38A20.868
FXR10.868
MORC30.862
PAPOLA0.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.625
OR4F29-0.613
HES5-0.27
FOXS1-0.224
MYLK2-0.222
COX4I2-0.212
REM1-0.21
TIGIT-0.206
UPB1-0.204
PTGDR2-0.198

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PPP4R2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PPP4R2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PPP4R2 mRNA24449571
D001379AzathioprineAzathioprine results in increased expression of PPP4R2 mRNA19192274
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPP4R2 mRNA21632981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP4R2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of PPP4R2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PPP4R2 mRNA21297351
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP4R2 mRNA23650126
C059262cidofovircidofovir results in decreased expression of PPP4R2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of PPP4R2 mRNA25596134
D019327Copper SulfateCopper Sulfate results in decreased expression of PPP4R2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PPP4R2 mRNA19770486
D003976DiazinonDiazinon results in increased methylation of PPP4R2 gene22964155
D002945CisplatinCisplatin results in decreased expression of PPP4R2 mRNA25596134
C000944dicrotophosdicrotophos results in decreased expression of PPP4R2 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PPP4R2 protein23301498
D005485FlutamideFlutamide results in increased expression of PPP4R2 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PPP4R2 mRNA20655997|2364984
D005839GentamicinsGentamicins results in increased expression of PPP4R2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of PPP4R2 mRNA24136188
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of PPP4R2 mRNA19192274
D007213IndomethacinIndomethacin results in decreased expression of PPP4R2 mRNA16984733
C410337K 7174K 7174 results in increased expression of PPP4R2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of PPP4R2 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of PPP4R2 mRNA19751817
D008687MetforminMetformin results in decreased expression of PPP4R2 mRNA25596134
D008727MethotrexateMethotrexate results in increased expression of PPP4R2 mRNA19192274
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PPP4R2 mRNA"25926378
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PPP4R2 mRNA28001369
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PPP4R2 mRNA"25926378
D010100OxygenOxygen deficiency affects the expression of PPP4R2 mRNA25596134
D010634PhenobarbitalPhenobarbital affects the expression of PPP4R2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of PPP4R2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PPP4R2 mRNA26272509
D010894PiroxicamPiroxicam results in increased expression of PPP4R2 mRNA19192274
D010936Plant ExtractsPlant Extracts results in increased expression of PPP4R2 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PPP4R2 mRNA21334430
D012834SilverSilver results in decreased expression of PPP4R2 mRNA27131904
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PPP4R2 mRNA28065790
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PPP4R2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of PPP4R2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16085932  17353931  18614045  18715871  19156129  20154705  
26496610  28330616  
GO:0019888protein phosphatase regulator activity-IBA21873635  
GO:0019888protein phosphatase regulator activity-IMP20154705  
GO:0030674protein binding, bridging-IMP20154705  
GO ID GO Term Qualifier Evidence PubMed
GO:0006397mRNA processing-IEA-  
GO:0006464cellular protein modification process-TAS10769191  
GO:0006470protein dephosphorylation-IBA21873635  
GO:0008380RNA splicing-IEA-  
GO:0010569regulation of double-strand break repair via homologous recombination-IMP20154705  
GO:0043666regulation of phosphoprotein phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20154705  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005813centrosome-TAS10769191  
GO:0030289protein phosphatase 4 complex-IBA21873635  
GO:0030289protein phosphatase 4 complex-IDA20154705  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal