Gene: CMC1

152100
C3orf68
C-X9-C motif containing 1
protein-coding
3p24.1
Ensembl:ENSG00000187118 MIM:615166 Vega:OTTHUMG00000155660 UniprotKB:Q7Z7K0
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.744e-1 (AD)  4.056e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11706542chr3:28287092 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EEF1E10.883
NDUFAB10.877
RSL24D10.875
TOMM50.874
TMED30.867
MRPS230.863
ZNHIT30.859
MRPS330.857
NFU10.856
MALSU10.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.557
OR4F29-0.499
P2RY14-0.405
ANPEP-0.369
SLC26A5-0.344
KCNK5-0.341
MMP9-0.34
HIF3A-0.336
SLC2A4-0.332
VNN3-0.329

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of CMC1 mRNA17562736
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CMC1 promoter]19654925
D004958EstradiolEstradiol results in decreased expression of CMC1 mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of CMC1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CMC1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CMC1 gene28505145
C018021cobaltous chloridecobaltous chloride results in increased expression of CMC1 mRNA22982409
D016572CyclosporineCyclosporine results in decreased expression of CMC1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CMC1 mRNA]27941970
D005485FlutamideFlutamide results in increased expression of CMC1 mRNA24136188
C492448ICG 001ICG 001 results in decreased expression of CMC1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CMC1 mRNA25613284
C008261lead acetatelead acetate results in decreased expression of CMC1 mRNA21829687
C045463leflunomideleflunomide results in increased expression of CMC1 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CMC1 mRNA25729387
D011441PropylthiouracilPropylthiouracil results in decreased expression of CMC1 mRNA24780913
C017947sodium arsenitesodium arsenite affects the expression of CMC1 mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CMC1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CMC1 mRNA25613284
D014050TolueneToluene results in decreased expression of CMC1 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CMC1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CMC1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CMC1 gene27618143
D014520UrethaneUrethane results in decreased expression of CMC1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of CMC1 mRNA29154799
C025643vinclozolinvinclozolin results in increased expression of CMC1 mRNA23869203
D055549Volatile Organic CompoundsVolatile Organic Compounds affects the expression of CMC1 mRNA20823639
D019287Zinc SulfateZinc Sulfate results in increased expression of CMC1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA23676665  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal