Gene: CMTM8

152189
CKLFSF8|CKLFSF8-V2
CKLF like MARVEL transmembrane domain containing 8
protein-coding
3p22.3
Ensembl:ENSG00000170293 MIM:607891 Vega:OTTHUMG00000130753 UniprotKB:Q8IZV2
NC_000003.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.073e-1 (AD)  4.882e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BMP60.758
ELOVL70.75
ITGA10.741
VWF0.727
GRAP0.724
PAPSS20.721
CYYR10.717
ERG0.715
CDH50.713
GGT50.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNF1A-0.395
WNT7A-0.364
KNCN-0.364
MARCH4-0.326
ATP2C2-0.324
OR4F29-0.321
CPLX3-0.319
LRTM2-0.317
NEUROD6-0.317
ANKRD34A-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CMTM8 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CMTM8 mRNA"28903501
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CMTM8 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CMTM8 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of CMTM8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CMTM8 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CMTM8 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CMTM8 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CMTM8 mRNA28522335
D001151ArsenicArsenic affects the expression of CMTM8 mRNA18414638
C006632arsenic trioxidearsenic trioxide results in decreased expression of CMTM8 mRNA15761015
D001280AtrazineAtrazine results in increased expression of CMTM8 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CMTM8 mRNA22228805
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CMTM8 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CMTM8 mRNA25181051
D003375CoumestrolCoumestrol results in decreased expression of CMTM8 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of CMTM8 mRNA25562108|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CMTM8 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of CMTM8 mRNA19561079
D004041Dietary FatsDietary Fats results in decreased expression of CMTM8 mRNA25016146
D004237DiuronDiuron results in decreased expression of CMTM8 mRNA21551480
C118739entinostatentinostat results in increased expression of CMTM8 mRNA27188386
C546771gardiquimodgardiquimod results in increased expression of CMTM8 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CMTM8 mRNA]28003376
D005839GentamicinsGentamicins results in decreased expression of CMTM8 mRNA22061828
D017313FenretinideFenretinide results in increased expression of CMTM8 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CMTM8 mRNA25613284
C410337K 7174K 7174 results in increased expression of CMTM8 mRNA24086573
D007649KetamineKetamine results in increased expression of CMTM8 mRNA20080153
C045463leflunomideleflunomide results in increased expression of CMTM8 mRNA24136188
D008694MethamphetamineMethamphetamine results in decreased expression of CMTM8 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CMTM8 mRNA23179753
C523799MRK 003CMTM8 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CMTM8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CMTM8 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of CMTM8 mRNA24136188
C025589ochratoxin Aochratoxin A results in increased acetylation of CMTM8 promoter29098329
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CMTM8 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CMTM8 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CMTM8 mRNA19710929
C045950propiconazolepropiconazole results in decreased expression of CMTM8 mRNA21278054
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CMTM8 mRNA]28003376
D012834SilverSilver results in increased expression of CMTM8 mRNA27131904
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CMTM8 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CMTM8 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of CMTM8 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CMTM8 mRNA18796159|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CMTM8 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CMTM8 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CMTM8 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of CMTM8 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CMTM8 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of CMTM8 mRNA17292431
D014638VanadatesVanadates results in decreased expression of CMTM8 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CMTM8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI16263120  
GO:0019911structural constituent of myelin sheath-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0042552myelination-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict