Gene info: ID 1523

Gene: CUX1

GENE ID: 1523

Synonyms: CASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GOLIM6|Nbla10317|p100|p110|p200|p75

Description: cut like homeobox 1

Gene type: protein-coding

Location: 7q22.1

dbXrefs: Ensembl:ENSG00000257923 MIM:116896 Vega:OTTHUMG00000157129 UniprotKB:P39880

RefSeq: NG_029476.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.244e-1 (AD) 2.097e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14012925	chr7:101556907	CUX1		2.400e-18	Smoking	27651444
cg15600935	chr7:101556684	CUX1		5.700e-14	Smoking	27651444
cg09762515	chr7:101556588	CUX1		1.000e-9	Smoking	27651444
cg27405731	chr7:101571203	CUX1		4.600e-9	Smoking	27651444
cg26249245	chr7:101915942	CUX1		2.100e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ACO2	0.824
EEF2	0.821
AKT1	0.811
MED29	0.81
HNRNPUL1	0.804
MLLT6	0.799
PARP1	0.798
RAB5C	0.794
MAPKAP1	0.793
FAM210B	0.791

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.752
OR4F29	-0.742
C17orf112	-0.195
KRT16	-0.183
KRT6B	-0.168
HMHB1	-0.168
PGLYRP4	-0.157
KRT6C	-0.153
SPRR2D	-0.152
CLEC6A	-0.151

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of CUX1 mRNA"	19114083
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CUX1 mRNA	12419474
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of CUX1 mRNA	21420995
D020106	Acrylamide	Acrylamide results in increased expression of CUX1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CUX1 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CUX1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CUX1 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of CUX1 gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CUX1 mRNA	20064835\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CUX1 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUX1 mRNA"	19150397\|2001819
C006780	bisphenol A	bisphenol A affects the expression of CUX1 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of CUX1 mRNA	17553608
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of CUX1 mRNA	12419474
C018475	butyraldehyde	butyraldehyde results in decreased expression of CUX1 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CUX1 mRNA	12160620
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CUX1 mRNA	18804290
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CUX1 mRNA	17484886
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CUX1 gene	20938992
D003300	Copper	MT1 affects the reaction [Copper results in increased expression of CUX1 mRNA]	16629173
D003300	Copper	MT2 affects the reaction [Copper results in increased expression of CUX1 mRNA]	16629173
D003471	Cuprizone	Cuprizone results in increased expression of CUX1 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of CUX1 mRNA	25562108
D002945	Cisplatin	Cisplatin results in decreased expression of CUX1 mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased expression of CUX1 mRNA	22023808
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CUX1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUX1 mRNA	17942748
D015025	Zearalenone	Zearalenone results in decreased expression of CUX1 mRNA	19371625
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CUX1 gene	20938992
D019833	Genistein	Genistein results in increased expression of CUX1 mRNA	15256057
D005839	Gentamicins	Gentamicins results in decreased expression of CUX1 mRNA	22061828
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of CUX1 mRNA	22634610
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA	19695318
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CUX1 mRNA	12419474
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CUX1 mRNA	18951874
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CUX1 mRNA	23086925
D048628	Ketolides	Ketolides analog results in decreased expression of CUX1 mRNA	24967691
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CUX1 mRNA	21641980
D008694	Methamphetamine	Methamphetamine results in increased expression of CUX1 mRNA	19564919
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CUX1 gene	20938992
D008752	Methylene Chloride	Methylene Chloride results in decreased expression of CUX1 mRNA	28392392
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of CUX1 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in increased expression of CUX1 mRNA	15674843
D009151	Mustard Gas	Mustard Gas affects the expression of CUX1 mRNA	15651846
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of CUX1 mRNA	19812364
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of CUX1 mRNA	25729387
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of CUX1 mRNA	23948077
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of CUX1 mRNA	23892564
C006253	pirinixic acid	pirinixic acid results in increased expression of CUX1 mRNA	18301758
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of CUX1 mRNA	21334430
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA	19695318
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CUX1 mRNA	24780913
C009131	pyrimidin-2-one beta-ribofuranoside	pyrimidin-2-one beta-ribofuranoside results in decreased expression of CUX1 mRNA	19194470
C059514	resveratrol	resveratrol results in decreased expression of CUX1 mRNA	19371625
D012402	Rotenone	Rotenone results in increased expression of CUX1 mRNA	19013527
D012834	Silver	Silver results in increased expression of CUX1 mRNA	26014281
C009277	sodium arsenate	sodium arsenate results in increased expression of CUX1 mRNA	21795629
D012999	Soman	Soman results in increased expression of CUX1 mRNA	19281266
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CUX1 mRNA	21641980
D013629	Tamoxifen	Tamoxifen results in decreased expression of CUX1 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CUX1 mRNA	21570461\|2405805
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of CUX1 mRNA	19465110
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUX1 mRNA	17942748
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of CUX1 gene	26756918
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of CUX1 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of CUX1 mRNA	25729387
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX1 mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of CUX1 mRNA	28542535
C012589	trichostatin A	trichostatin A results in decreased expression of CUX1 mRNA	26272509
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CUX1 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of CUX1 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased expression of CUX1 mRNA	28001369\|2915479
D014635	Valproic Acid	Valproic Acid results in increased methylation of CUX1 gene	29154799
D014639	Vanadium	Vanadium results in increased activity of CUX1 protein	19000753
D014810	Vitamin E	Vitamin E results in decreased expression of CUX1 mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of CUX1 mRNA	27188386
D015032	Zinc	Zinc deficiency results in increased activity of CUX1 protein	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IBA	21873635
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	ISS	-
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	12891711
GO:0030674	protein binding, bridging	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IDA	15656993

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	1301999
GO:0000301	retrograde transport, vesicle recycling within Golgi	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	1301999
GO:0007275	multicellular organism development	-	TAS	1301999
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0048193	Golgi vesicle transport	-	IBA	21873635
GO:0050775	positive regulation of dendrite morphogenesis	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IBA	21873635
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	15656993
GO:0005654	nucleoplasm	-	IDA	-
GO:0005794	Golgi apparatus	-	IDA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	TAS
R-HSA-1839124	FGFR1 mutant receptor activation	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5655302	Signaling by FGFR1 in disease	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-6811438	Intra-Golgi traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28592245	In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)	El-Aarag SA	BMC Med Genomics
26812355	RNA-sequencing study of peripheral blood monocytes in chronic periodontitis. (2016 May 1)	Liu YZ	Gene