Gene: CX3CR1

1524
CCRL1|CMKBRL1|CMKDR1|GPR13|GPRV28|V28
C-X3-C motif chemokine receptor 1
protein-coding
3p22.2
Ensembl:ENSG00000168329 MIM:601470 Vega:OTTHUMG00000156249 UniprotKB:P49238
NG_016362.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.903e-1 (AD)  8.327e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03341377chr3:39309355CX3CR15.400e-9Smoking27651444
cg22917487chr3:39322103CX3CR15.060e-10Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
P2RY120.926
P2RY130.897
SUSD30.892
MPEG10.862
BLNK0.854
GPR340.845
IGSF60.843
SELPLG0.838
TMEM1190.819
FOLR20.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBB2-0.36
NTSR2-0.316
CNTFR-0.31
ERAS-0.307
BGLAP-0.307
HES6-0.303
MISP-0.299
KLHL25-0.298
WNT11-0.294
FAM43B-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CX3CR1 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CX3CR1 mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of CX3CR1 mRNA"25710175
C112040A2-E (N-retinylidene-N-retinylethanolamine)CX3CR1 protein affects the abundance of A2-E (N-retinylidene-N-retinylethanolamine)20361964
C112040A2-E (N-retinylidene-N-retinylethanolamine)Quercetin inhibits the reaction [CX3CR1 protein affects the abundance of A2-E (N-retinylidene-N-retinylethanolamine)]20361964
D000082AcetaminophenAcetaminophen results in increased expression of CX3CR1 mRNA26690555
D000082Acetaminophen[MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of CX3CR1 mRNA22575169
D000393Air PollutantsAir Pollutants results in decreased expression of CX3CR1 mRNA27777102
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CX3CR1 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CX3CR1 mRNA16483693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene affects the expression of CX3CR1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CX3CR1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CX3CR1 mRNA21569818
D056804BiofuelsBiofuels results in decreased expression of CX3CR1 mRNA27777102
C006780bisphenol Abisphenol A affects the expression of CX3CR1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of CX3CR1 mRNA24376830
D002185CannabidiolCannabidiol results in decreased expression of CX3CR1 mRNA21542829
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CX3CR1 mRNA23288052
D002794CholineCholine affects the expression of CX3CR1 mRNA17616785
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA23439872
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of CX3CR1 mRNA26577399
D003520CyclophosphamideCyclophosphamide results in increased expression of CX3CR1 protein16651033
D003976DiazinonDiazinon results in decreased expression of CX3CR1 mRNA24356939
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CX3CR1 mRNA28085963
C118739entinostatentinostat results in increased expression of CX3CR1 mRNA27188386
C000499ferric oxideferric oxide analog results in decreased expression of CX3CR1 mRNA25086211
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA23439872
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA20938992
C425931GW 501516GW 501516 results in decreased expression of CX3CR1 mRNA19850645
C008261lead acetatelead acetate results in increased expression of CX3CR1 mRNA21829687
C423914LG 268LG 268 results in decreased expression of CX3CR1 mRNA19850645
D001556LindaneLindane results in decreased expression of CX3CR1 mRNA24356939
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CX3CR1 mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CX3CR1 mRNA21846543
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CX3CR1 mRNA21641980
D008466MechlorethamineMechlorethamine results in increased expression of CX3CR1 mRNA26273949|2818490
D008466MechlorethamineMechlorethamine results in increased expression of CX3CR1 protein26273949
D008466MechlorethamineValproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA]28184907
D008694MethamphetamineMethamphetamine results in decreased expression of CX3CR1 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CX3CR1 mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"CX3CR1 protein affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"18410508
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CX3CR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CX3CR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CX3CR1 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CX3CR1 mRNA19812364
D009532NickelNickel results in decreased expression of CX3CR1 mRNA23195993
D009532NickelNickel results in increased expression of CX3CR1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of CX3CR1 mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CX3CR1 mRNA"19013360
C025589ochratoxin Aochratoxin A metabolite results in increased expression of CX3CR1 mRNA24356939
C025589ochratoxin Aochratoxin A results in increased expression of CX3CR1 mRNA24356939
D010100OxygenOxygen deficiency results in increased expression of CX3CR1 mRNA17476338
D010100OxygenOxygen deficiency results in increased expression of CX3CR1 protein17476338
D010100OxygenOxygen deficiency results in decreased expression of CX3CR1 mRNA24205000
D010269ParaquatCX3CR1 protein results in decreased susceptibility to Paraquat23299473
D010634PhenobarbitalPhenobarbital results in increased expression of CX3CR1 mRNA19084549
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of CX3CR1 mRNA16386258
D059808PolyphenolsPolyphenols results in decreased expression of CX3CR1 mRNA16293270
D011374ProgesteroneProgesterone results in decreased expression of CX3CR1 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of CX3CR1 mRNA24780913
D011794QuercetinQuercetin affects the reaction [CX3CR1 protein affects the activity of PTGS2 protein]20361964
D011794QuercetinQuercetin inhibits the reaction [CX3CR1 protein affects the abundance of A2-E (N-retinylidene-N-retinylethanolamine)]20361964
D011794QuercetinQuercetin inhibits the reaction [CX3CR1 protein affects the expression of BAX mRNA]20361964
C089730rosiglitazonerosiglitazone affects the localization of CX3CR1 protein19850645
C089730rosiglitazonerosiglitazone results in decreased expression of CX3CR1 mRNA19850645
C089730rosiglitazonePPARG affects the reaction [rosiglitazone results in decreased expression of CX3CR1 mRNA]19850645
C089730rosiglitazonerosiglitazone results in decreased expression of CX3CR1 mRNA19850645
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CX3CR1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CX3CR1 mRNA19073995
D019821SimvastatinSimvastatin results in decreased expression of CX3CR1 mRNA18359719
D012906SmokeSmoke affects the expression of CX3CR1 mRNA23693141
C017947sodium arsenitesodium arsenite affects the methylation of CX3CR1 gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of CX3CR1 mRNA18175754
D012999SomanSoman results in increased expression of CX3CR1 mRNA19281266
D053260SootSoot affects the expression of CX3CR1 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CX3CR1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CX3CR1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CX3CR1 mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CX3CR1 mRNA20133372
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of CX3CR1 mRNA]15363585
D014635Valproic AcidValproic Acid results in increased methylation of CX3CR1 gene29154799
D014635Valproic AcidValproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA]28184907
C066075vanadium pentoxidevanadium pentoxide results in increased expression of CX3CR1 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CX3CR1 mRNA27777102

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004950chemokine receptor activity-TAS10754298  
GO:0005515protein binding-IPI9931005  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016495C-X3-C chemokine receptor activity-IEA-  
GO:0019956chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IBA21873635  
GO:0019960C-X3-C chemokine binding-IDA23125415  
GO ID GO Term Qualifier Evidence PubMed
GO:0002052positive regulation of neuroblast proliferation-IEA-  
GO:0002282microglial cell activation involved in immune response-IEA-  
GO:0006935chemotaxis-IBA21873635  
GO:0006935chemotaxis-TAS10754298  
GO:0006955immune response-IBA21873635  
GO:0006968cellular defense response-TAS10754298  
GO:0007155cell adhesion-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007613memory-IEA-  
GO:0009611response to wounding-TAS10754298  
GO:0016032viral process-IEA-  
GO:0016525negative regulation of angiogenesis-IEA-  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0021795cerebral cortex cell migration-IEA-  
GO:0030336negative regulation of cell migration-IEA-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0048246macrophage chemotaxis-IEA-  
GO:0060326cell chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071560cellular response to transforming growth factor beta stimulus-IEA-  
GO:1900272negative regulation of long-term synaptic potentiation-IEA-  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9390561  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0032809neuronal cell body membrane-IEA-  
GO:0043005neuron projection-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25830914Transcriptome analysis in patients with chronic kidney disease on hemodialysis disclosing a key role for CD16+CX3CR1+ monocytes. (2015)Schepers EPLoS One
26464724CX3CR1 polymorphisms and the risk of age-related macular degeneration. (2015)Ma BInt J Clin Exp Pathol
19755791Polymorphisms of fractalkine receptor CX3CR1 gene in patients with symptomatic and asymptomatic carotid artery stenosis. (2009 Oct)Kimouli MJ Atheroscler Thromb
22816662Association of sequence variation in the CX3CR1 gene with geographic atrophy age-related macular degeneration in a Greek population. (2012 Dec)Anastasopoulos ECurr Eye Res
19372452Fractalkine receptor/ligand genetic variants and carotid intima-media thickness. (2009 Jun)Debette SStroke
16823865An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation. (2006 Oct)Bojanowski CMEnviron Mol Mutagen
19628406Association of polymorphisms in the chemokine receptor CX3CR1 gene with coronary artery disease. (2009 Sep)Matzhold EMCytokine
20538655Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. (2010 Sep)Yang XBr J Ophthalmol
29565837Polymorphisms in Selected Genes and Their Association with Age-Related Macular Degeneration in a Chinese Population. (2018 Mar 22)Huang QMed Sci Monit
11264153Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. (2001 Apr 1)Moatti DBlood