Gene: CXADR

1525
CAR|CAR4/6|HCAR
CXADR, Ig-like cell adhesion molecule
protein-coding
21q21.1
Ensembl:ENSG00000154639 MIM:602621 Vega:OTTHUMG00000074508 UniprotKB:P78310
NG_029458.1
SNP Mapped
3   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.000e-1 (AD)  1.914e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2249449chr21:17560125 (GRCh38.p7)A>G / A>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs2249443chr21:17560034 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs2249100chr21:17557426 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM240.778
MARCH10.775
ARPC50.762
ZMYM20.744
NLGN10.741
ARID4A0.74
ATE10.738
C5orf150.736
ABCE10.735
SPAST0.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.439
OR4F29-0.4
PLIN4-0.342
WDR38-0.341
SIX5-0.335
EYA2-0.325
NWD1-0.324
ADAMTSL5-0.32
RFX2-0.313
RAPSN-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CXADR mRNA"28903501
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CXADR mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CXADR mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CXADR mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of CXADR protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXADR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXADR mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of CXADR mRNA"28073004
D000082AcetaminophenAcetaminophen results in decreased expression of CXADR mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CXADR mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CXADR mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CXADR mRNA16483693
D001151ArsenicArsenic affects the methylation of CXADR gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CXADR mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXADR mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXADR mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXADR mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CXADR mRNA"19150397|2001819
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CXADR mRNA"20382639
D004958EstradiolEstradiol affects the expression of CXADR mRNA23557687
D004958EstradiolEstradiol affects the expression of CXADR mRNA14699072
D004958EstradiolEstradiol results in increased expression of CXADR mRNA18618240
D004958EstradiolEstradiol results in increased expression of CXADR mRNA alternative form18618240
D004958EstradiolEstradiol results in increased expression of CXADR protein18618240
D004958EstradiolEstradiol results in increased expression of CXADR protein alternative form18618240
C006780bisphenol Abisphenol A results in increased expression of CXADR mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of CXADR mRNA25181051
C086232bosentanbosentan results in decreased expression of CXADR mRNA20392896
C086232bosentanbosentan results in decreased expression of CXADR protein20392896
C086232bosentanEDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]20392896
C086539BQ 788BQ 788 results in decreased expression of CXADR mRNA20392896
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CXADR mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of CXADR mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CXADR promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CXADR mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CXADR gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of CXADR mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of CXADR mRNA17585979
C480342clothianidinclothianidin results in increased expression of CXADR mRNA29044138
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CXADR mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of CXADR mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CXADR mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of CXADR mRNA19770486
C014347decitabinedecitabine promotes the reaction [trichostatin A results in increased expression of CXADR mRNA]18618240
C014347decitabinedecitabine promotes the reaction [trichostatin A results in increased expression of CXADR mRNA alternative form]18618240
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CXADR mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CXADR mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of CXADR mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of CXADR mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of CXADR mRNA]19030233
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CXADR mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CXADR mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of CXADR mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CXADR mRNA21592394
C100264enniatinsenniatins results in decreased expression of CXADR mRNA27163883
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CXADR mRNA17557909
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CXADR gene20938992
D005839GentamicinsGentamicins results in increased expression of CXADR mRNA22061828
D017313FenretinideFenretinide results in increased expression of CXADR mRNA28973697
C492448ICG 001ICG 001 results in increased expression of CXADR mRNA26191083
C544151jinfukangjinfukang results in decreased expression of CXADR mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CXADR mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CXADR gene20938992
C002950methylformamidemethylformamide affects the expression of CXADR mRNA17040096
C002950methylformamidemethylformamide analog affects the expression of CXADR mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CXADR mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CXADR mRNA26011545
D015735MifepristoneMifepristone results in decreased expression of CXADR mRNA25972201
D008942MitoxantroneCXADR protein affects the susceptibility to Mitoxantrone16217747
C523799MRK 003CXADR results in decreased susceptibility to MRK 00319903844
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CXADR mRNA25380136
C022838nickel chloridenickel chloride results in decreased expression of CXADR mRNA17312168
C028007nickel monoxidenickel monoxide results in decreased expression of CXADR mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of CXADR mRNA22714537
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CXADR mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of CXADR mRNA19095052
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CXADR mRNA19710929
C045950propiconazolepropiconazole results in increased expression of CXADR mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of CXADR mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CXADR mRNA14699072
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of CXADR mRNA]19030233
D012906SmokeSmoke results in decreased expression of CXADR mRNA21095227
C016104sodium bichromatesodium bichromate results in increased expression of CXADR mRNA25993096
D013629TamoxifenTamoxifen results in increased expression of CXADR mRNA18618240
D013629TamoxifenTamoxifen results in increased expression of CXADR mRNA alternative form18618240
D013629TamoxifenTamoxifen results in increased expression of CXADR protein18618240
D013629TamoxifenTamoxifen results in increased expression of CXADR protein alternative form18618240
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CXADR mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CXADR mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CXADR mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXADR mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CXADR mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CXADR promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXADR mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXADR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CXADR mRNA21724226
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXADR mRNA21215274
C009495titanium dioxidetitanium dioxide affects the expression of CXADR mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of CXADR mRNA19464567|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CXADR mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CXADR mRNA20133372
C483909torcetrapibtorcetrapib results in increased expression of CXADR mRNA23228038
D014118Toxins, Biological"Toxins, Biological affects the expression of CXADR mRNA"19682533
C012589trichostatin Adecitabine promotes the reaction [trichostatin A results in increased expression of CXADR mRNA]18618240
C012589trichostatin Adecitabine promotes the reaction [trichostatin A results in increased expression of CXADR mRNA alternative form]18618240
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXADR mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CXADR mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of CXADR mRNA18618240
C012589trichostatin Atrichostatin A results in increased expression of CXADR mRNA alternative form18618240
D014635Valproic AcidValproic Acid results in increased expression of CXADR mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of CXADR mRNA17292431
D000068756ValsartanValsartan results in decreased expression of CXADR mRNA20392896
D000068756ValsartanValsartan results in decreased expression of CXADR protein20392896
D014640VancomycinVancomycin results in decreased expression of CXADR mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CXADR gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CXADR mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of CXADR mRNA"24525044
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CXADR mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005178integrin binding-IPI12869515  
GO:0005515protein binding-IPI11734628  17675666  
GO:0008013beta-catenin binding-IPI12297051  
GO:0030165PDZ domain binding-IPI15364909  
GO:0050839cell adhesion molecule binding-IPI12869515  15800062  
GO:0071253connexin binding-ISS-  
GO:0086082cell adhesive protein binding involved in AV node cell-bundle of His cell communication-IC18636119  
GO ID GO Term Qualifier Evidence PubMed
GO:0007005mitochondrion organization-ISS-  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IDA12869515  15800062  
GO:0007507heart development-ISS-  
GO:0008354germ cell migration-ISS-  
GO:0010669epithelial structure maintenance-IMP15304526  
GO:0030593neutrophil chemotaxis-IMP15800062  
GO:0031532actin cytoskeleton reorganization-IDA17675666  
GO:0045216cell-cell junction organization-ISS-  
GO:0046629gamma-delta T cell activation-ISS-  
GO:0046718viral entry into host cell-IEA-  
GO:0048739cardiac muscle fiber development-ISS-  
GO:0050776regulation of immune response-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0070633transepithelial transport-IMP15800062  
GO:0086067AV node cell to bundle of His cell communication-ISS-  
GO:0086072AV node cell-bundle of His cell adhesion involved in cell communication-ISS-  
GO:0098904regulation of AV node cell action potential-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-ISS-  
GO:0005576extracellular region-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA22003382  
GO:0005886plasma membrane-HDA16780588  
GO:0005886plasma membrane-IDA9096397  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS9096397  
GO:0005911cell-cell junction-IDA17675666  20235596  
GO:0005912adherens junction-IDA12297051  
GO:0005913cell-cell adherens junction-IDA25468996  
GO:0005923bicellular tight junction-IDA15800062  22003382  
GO:0016323basolateral plasma membrane-IDA20361046  
GO:0016327apicolateral plasma membrane-IDA15364909  
GO:0030054cell junction-IDA-  
GO:0030175filopodium-ISS-  
GO:0030426growth cone-ISS-  
GO:0032991protein-containing complex-IDA17675666  
GO:0043005neuron projection-ISS-  
GO:0044297cell body-ISS-  
GO:0045121membrane raft-IDA17675666  
KEGG ID KEGG Term
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal