Gene: CYB5A

1528
CYB5|MCB5|METAG
cytochrome b5 type A
protein-coding
18q22.3
Ensembl:ENSG00000166347 MIM:613218 Vega:OTTHUMG00000132843 UniprotKB:P00167
NG_023211.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.873e-2 (AD)  2.904e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC61B0.895
LSM20.879
COA40.872
MYL60.863
EMG10.858
PPIB0.855
SNRPG0.855
SEC11C0.854
SSR40.854
UBE2E10.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.682
OR4F29-0.674
SSX5-0.205
CCR8-0.199
PRDM14-0.197
SDIM1-0.185
OR56A3-0.183
GRXCR2-0.182
TAS2R41-0.179
OR10K1-0.175

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04009Dimethyl Propionate Ester HemeSmall MoleculeExperimentalTarget
DB11136ChromiumSmall Molecule7440-47-3ApprovedTarget
ID Drug Name Action PubMed
C0099471,2,4-trichlorobenzene"1,2,4-trichlorobenzene results in increased activity of CYB5A protein"6605599
C0099471,2,4-trichlorobenzene"1,2,4-trichlorobenzene results in increased activity of CYB5A protein"8212004
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CYB5A mRNA"16269432
C51721412-hydroxyellipticine[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]22390216
C51721513-hydroxyellipticine[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
C51721513-hydroxyellipticineCYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYB5A mRNA"28903501
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with LHB protein] results in decreased expression of CYB5A mRNA"23333615
C0243361-phenylazo-2-naphtholCYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0243361-phenylazo-2-naphtholCYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0243361-phenylazo-2-naphtholCYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0243361-phenylazo-2-naphtholCYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0243361-phenylazo-2-naphtholCYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0243361-phenylazo-2-naphtholCYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0243361-phenylazo-2-naphtholCYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775|1935888
C0243361-phenylazo-2-naphtholCYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0835222,3,5-trichlorophenyl methyl sulfone"2,3,5-trichlorophenyl methyl sulfone results in increased activity of CYB5A protein"8212004
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of CYB5A protein"27604104
C0065932-anthramineCYB5A protein promotes the reaction [CYP1A2 protein results in increased activity of 2-anthramine]15728263
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of CYB5A mRNA16014739
C0312853-xylene3-xylene results in decreased expression of CYB5A mRNA12815608
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]15728263
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C0765807-methoxyresorufinCYB5A protein inhibits the reaction [CYP1A2 protein results in decreased methylation of 7-methoxyresorufin]15728263
D000082AcetaminophenAcetaminophen results in decreased expression of CYB5A mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of CYB5A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYB5A mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CYB5A gene27153756
C430898AGN 194204AGN 194204 results in increased expression of CYB5A mRNA16339527
D000393Air PollutantsAir Pollutants analog results in decreased expression of CYB5A mRNA21757418
D015760AlfentanilCYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]15557344
D015760AlfentanilCYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]15557344
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane affects the expression of CYB5A mRNA17785943
C005451alpha-pinenealpha-pinene results in increased expression of CYB5A mRNA10620039
D000499AllylamineAllylamine results in increased expression of CYB5A mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYB5A mRNA16483693
C000228aristolochic acid I[CYP2C11 protein co-treated with CYB5A protein] results in increased abundance of aristolochic acid I metabolite21362632
C000228aristolochic acid I[CYP2C11 protein co-treated with CYB5A protein] results in increased metabolism of aristolochic acid I21362632
C000228aristolochic acid I[CYP2C12 protein co-treated with CYB5A protein] results in increased abundance of aristolochic acid I metabolite21362632
C000228aristolochic acid I[CYP2C12 protein co-treated with CYB5A protein] results in increased metabolism of aristolochic acid I21362632
C000228aristolochic acid I[CYP2C13 protein co-treated with CYB5A protein] results in increased abundance of aristolochic acid I metabolite21362632
C000228aristolochic acid I[CYP2C13 protein co-treated with CYB5A protein] results in increased metabolism of aristolochic acid I21362632
C000228aristolochic acid I[CYP2C6V1 protein co-treated with CYB5A protein] results in increased abundance of aristolochic acid I metabolite21362632
C000228aristolochic acid I[CYP2C6V1 protein co-treated with CYB5A protein] results in increased metabolism of aristolochic acid I21362632
C015001arsenitearsenite results in increased expression of CYB5A mRNA18929588
D001205Ascorbic Acid[Ascorbic Acid deficiency co-treated with Buthionine Sulfoximine] results in decreased expression of CYB5A mRNA20221587
D001205Ascorbic Acid[Ascorbic Acid deficiency co-treated with Buthionine Sulfoximine] results in decreased expression of CYB5A protein20221587
D001280AtrazineAtrazine results in increased expression of CYB5A protein26775023
D001280Atrazinelycopene inhibits the reaction [Atrazine results in increased expression of CYB5A protein]26775023
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CYB5A mRNA23656968
C056612benzo(a)pyrene-DNA adductCYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]24530354
C056612benzo(a)pyrene-DNA adductEPHX1 protein affects the reaction [CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]]24530354
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CYB5A mRNA16269432
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CYB5A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYB5A mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYB5A mRNA21715664|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYB5A protein22759596
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased expression of CYB5A protein]22759596
D001564Benzo(a)pyreneCYB5A protein promotes the reaction [[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene]24530354
D001564Benzo(a)pyreneCYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]24530354
D001564Benzo(a)pyrene[CYP1A1 protein co-treated with CYB5A protein] results in increased oxidation of Benzo(a)pyrene24530354
D001564Benzo(a)pyreneEPHX1 protein affects the reaction [CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]]24530354
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CYB5A mRNA"20382639
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CYB5A mRNA20660070
C044887beta-methylcholinebeta-methylcholine affects the expression of CYB5A mRNA21179406
C095105bexarotenebexarotene results in decreased expression of CYB5A mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of CYB5A mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of CYB5A mRNA25181051
C032036bromobenzenebromobenzene results in increased expression of CYB5A mRNA12628495
D019328Buthionine Sulfoximine[Ascorbic Acid deficiency co-treated with Buthionine Sulfoximine] results in decreased expression of CYB5A mRNA20221587
D019328Buthionine Sulfoximine[Ascorbic Acid deficiency co-treated with Buthionine Sulfoximine] results in decreased expression of CYB5A protein20221587
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CYB5A mRNA]20360939
D002220CarbamazepineCarbamazepine results in increased expression of CYB5A mRNA17112801
D002509CephaloridineCephaloridine results in increased expression of CYB5A mRNA18172885
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYB5A mRNA18160741
D002721omega-Chloroacetophenoneomega-Chloroacetophenone results in increased expression of CYB5A protein7934086
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CYB5A protein8471063
D002753ChlorzoxazoneCYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]15728263
D002994ClofibrateClofibrate results in decreased expression of CYB5A mRNA12851107
D002995Clofibric AcidClofibric Acid affects the expression of CYB5A mRNA17602206
D009249NADP[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]22390216
D009249NADP[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
D009249NADPCYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
D019327Copper SulfateCopper Sulfate results in decreased expression of CYB5A mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CYB5A mRNA20106945|2556210
C017160cypermethrincypermethrin results in increased expression of CYB5A mRNA10620039
C093628cyproconazolecyproconazole results in increased expression of CYB5A mRNA22334560
D003561CytarabineCytarabine results in decreased expression of CYB5A mRNA21198554
D003671DEETDEET results in increased expression of CYB5A mRNA27091632
D003671DEET[fipronil co-treated with DEET] results in increased expression of CYB5A mRNA27091632
D003907DexamethasoneDexamethasone results in increased expression of CYB5A mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CYB5A mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of CYB5A mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CYB5A mRNA21266533
D002945CisplatinCisplatin results in increased expression of CYB5A mRNA27594783
D002945CisplatinCisplatin results in decreased expression of CYB5A mRNA18172885
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CYB5A mRNA26924002
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA18313992
D004041Dietary FatsDietary Fats results in decreased expression of CYB5A mRNA18042831
C014476diethyl maleatediethyl maleate results in increased expression of CYB5A mRNA25270620
D004052DiethylnitrosamineCYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of Diethylnitrosamine]15728263
D004052DiethylnitrosamineCYB5A protein promotes the reaction [CYP2E1 protein results in increased activity of Diethylnitrosamine]15728263
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CYB5A mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYB5A mRNA]17942915
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CYB5A mRNA]20360939
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYB5A protein19409407
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CYB5A mRNA20360939
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of CYB5A protein20935162
C024808diisopropyl 1,3-dithiol-2-ylidenemalonate"diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of CYB5A protein"3689822
C024808diisopropyl 1,3-dithiol-2-ylidenemalonate"diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of [CYB5A protein results in increased metabolism of Halothane]"3689822
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYB5A protein"24995432|2709172
D0151279,10-Dimethyl-1,2-benzanthracene"tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYB5A protein]"24995432
D0151279,10-Dimethyl-1,2-benzanthracene"Taurine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYB5A protein]"27091720
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased activity of CYB5A protein"19497424
D0198131,2-Dimethylhydrazine"hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein]"19497424
D004147DioxinsDioxins affects the expression of CYB5A mRNA20463971
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of CYB5A mRNA"15706880
C109476epoxiconazoleepoxiconazole results in increased expression of CYB5A mRNA22334560
D000431EthanolEthanol results in decreased expression of CYB5A protein23200777
D000431EthanolEthanol results in increased activity of CYB5A protein28442378
D000431EthanolEthanol results in increased expression of CYB5A mRNA16946407
D000431Ethanolzingerone inhibits the reaction [Ethanol results in increased activity of CYB5A protein]28442378
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CYB5A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYB5A mRNA17942748
C017690fenvaleratefenvalerate results in increased expression of CYB5A mRNA10620039
C082360fipronil[fipronil co-treated with DEET] results in increased expression of CYB5A mRNA27091632
C082360fipronilfipronil results in increased expression of CYB5A mRNA27091632
C082360fipronilfipronil results in increased expression of CYB5A mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of CYB5A mRNA18035473
D005485FlutamideFlutamide results in decreased expression of CYB5A mRNA24793618
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of CYB5A protein]20884965
D019833GenisteinGenistein results in decreased expression of CYB5A protein20884965
D019833GenisteinGenistein results in decreased expression of CYB5A mRNA24967385
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of CYB5A mRNA21782745
D019833GenisteinGenistein results in increased expression of CYB5A mRNA21782745
D006221HalothaneCYB5A protein results in increased metabolism of Halothane3689822
D006221Halothane"diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of [CYB5A protein results in increased metabolism of Halothane]"3689822
D006418Heme[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]22390216
D006418Heme[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
D006418HemeCYB5A protein binds to Heme19358889
C013015hesperetin"hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein]"19497424
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CYB5A mRNA20044591
D002112CalcifediolCalcifediol deficiency results in decreased expression of CYB5A mRNA17293106
D019811HydroxylamineCYB5A protein results in increased reduction of Hydroxylamine21447608
C492448ICG 001ICG 001 affects the expression of CYB5A mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CYB5A mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of CYB5A mRNA18299717
D007220Industrial WasteIndustrial Waste results in decreased expression of CYB5A mRNA26055946
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CYB5A mRNA28628672
D007538IsoniazidIsoniazid results in decreased expression of CYB5A mRNA28619387
D007538Isoniazidsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]28619387
D007538Isoniazid[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA28619387
C544151jinfukangjinfukang results in increased expression of CYB5A mRNA27392435
C410337K 7174K 7174 results in decreased expression of CYB5A mRNA24086573
C008281limonenelimonene results in increased expression of CYB5A mRNA12815608
C015329lycopenelycopene inhibits the reaction [Atrazine results in increased expression of CYB5A protein]26775023
C042720mercuric bromidemercuric bromide results in increased expression of CYB5A mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of CYB5A mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of CYB5A mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CYB5A mRNA23179753|2718838
D008790MetoprololCYB5A affects the metabolism of Metoprolol20430864
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CYB5A mRNA26924002
C568376MT19c compoundMT19c compound results in increased expression of CYB5A mRNA21781307
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CYB5A mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYB5A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYB5A mRNA"25554681
C031721naphthalenenaphthalene results in decreased expression of CYB5A protein19438287
C051752nefazodonenefazodone results in increased expression of CYB5A mRNA24136188
C012655nimesulidenimesulide results in increased expression of CYB5A mRNA24136188
C013161N-nitroso(di-n-propyl)amineCYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of N-nitroso(di-n-propyl)amine]15728263
C013161N-nitroso(di-n-propyl)amineCYB5A protein promotes the reaction [CYP2E1 protein results in increased activity of N-nitroso(di-n-propyl)amine]15728263
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of CYB5A mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of CYB5A mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of CYB5A mRNA]"21673326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CYB5A mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of CYB5A mRNA18042831
D010269ParaquatParaquat results in increased expression of CYB5A mRNA21371552
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of CYB5A mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYB5A protein26879310
D026023PermethrinPermethrin results in increased expression of CYB5A mRNA10620039
D010578PetroleumPetroleum results in increased expression of CYB5A mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of CYB5A mRNA19084549
D010634PhenobarbitalPhenobarbital results in increased expression of CYB5A mRNA12807726
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYB5A protein19409407
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of CYB5A protein20935162
D010634PhenobarbitalPhenobarbital results in increased expression of CYB5A mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CYB5A mRNA26272509
D010703Phorbol EstersPhorbol Esters results in decreased expression of CYB5A mRNA15831526
D010795Phthalic AcidsPhthalic Acids results in decreased expression of CYB5A mRNA15728792
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYB5A mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYB5A mRNA19710929
D059808PolyphenolsPolyphenols results in decreased expression of CYB5A protein19370779
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CYB5A mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile affects the expression of CYB5A mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of CYB5A mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CYB5A mRNA20660070
C045950propiconazolepropiconazole results in increased expression of CYB5A mRNA21278054|2233456
C015586propiverinepropiverine binds to CYB5A protein29273565
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of CYB5A mRNA25626140
D011794QuercetinQuercetin results in decreased expression of CYB5A mRNA21632981
C052785rebamipiderebamipide results in increased expression of CYB5A mRNA18299717
C059514resveratrolresveratrol results in increased expression of CYB5A mRNA22610192
D015474IsotretinoinIsotretinoin results in decreased expression of CYB5A mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of CYB5A protein19556978
C440975silybinsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]28619387
C017947sodium arsenitesodium arsenite results in increased expression of CYB5A mRNA25270620
C016104sodium bichromatesodium bichromate results in decreased expression of CYB5A mRNA24612858
C059006tangeretin"tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYB5A protein]"24995432
D013654Taurine"Taurine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYB5A protein]"27091720
D013662TeaTea results in decreased expression of CYB5A protein19370779
D013739TestosteroneCYB5A affects the abundance of Testosterone20430864
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYB5A mRNA18160741
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5A mRNA16443690|1671440
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5A mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYB5A mRNA21570461|2821309
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CYB5A mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYB5A mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5A mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5A protein27105554
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYB5A mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYB5A mRNA18465118|2121527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5A mRNA18796159
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CYB5A mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of CYB5A mRNA16917069
D019284ThapsigarginThapsigargin results in decreased expression of CYB5A mRNA22378314
D019772TopotecanCYB5A protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CYB5A mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of CYB5A mRNA19254012
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CYB5A mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CYB5A mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of CYB5A mRNA22378314
D014520UrethaneUrethane results in decreased expression of CYB5A mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of CYB5A mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYB5A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CYB5A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CYB5A mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of CYB5A mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of CYB5A mRNA23665938
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CYB5A mRNA"25208076
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CYB5A mRNA"23246600
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA18313992
D015215Zidovudinesilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]28619387
D015215Zidovudine[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA28619387
D015215ZidovudineZidovudine results in decreased expression of CYB5A mRNA28619387
D015032ZincZinc results in decreased expression of CYB5A mRNA18172885
C013738zingeronezingerone inhibits the reaction [Ethanol results in increased activity of CYB5A protein]28442378

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004033aldo-keto reductase (NADP) activity-TAS-  
GO:0004129cytochrome-c oxidase activity-TAS1712589  
GO:0019899enzyme binding-IPI15680923  
GO:0020037heme binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0019852L-ascorbic acid metabolic process-TAS-  
GO:0022900electron transport chain-IEA-  
GO:0046686response to cadmium ion-IEA-  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IDA22375059  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196836Vitamin C (ascorbate) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25225034Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women. (2014 Nov)Blanke KLCancer Causes Control