Gene: KLB

152831
BKL
klotho beta
protein-coding
4p14
Ensembl:ENSG00000134962 MIM:611135 Vega:OTTHUMG00000128577 UniprotKB:Q86Z14
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
2   
6.607e-1 (AD)  7.888e-1 (ND)   (Frontal_Cortex)
3.301e-1 (AD)  9.977e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNB10.666
MAGEE20.629
SSTR30.624
ARMC90.62
GEMIN60.619
CEP190.618
ZNF3290.616
WSCD20.615
GFOD20.613
FAM135B0.612

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPKAPK3-0.421
ENDOU-0.412
SLC2A4-0.395
ALDH3B1-0.386
MBNL3-0.382
PARD3B-0.377
COPZ2-0.368
GPRC5C-0.363
FMO5-0.358
STON2-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of KLB mRNA"26238291
D000082AcetaminophenAcetaminophen affects the expression of KLB mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KLB mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLB gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KLB mRNA19770486
C547126AZM551248AZM551248 results in decreased expression of KLB mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLB mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLB mRNA21715664
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of KLB mRNA"26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLB mRNA"26238291
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of KLB mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of KLB mRNA27685785
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KLB mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of KLB mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of KLB mRNA25562108|2798913
C089595cylindrospermopsincylindrospermopsin results in decreased expression of KLB mRNA24921660
D003907DexamethasoneDexamethasone results in increased expression of KLB mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of KLB mRNA28628672
D004041Dietary FatsDietary Fats affects the expression of KLB mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of KLB mRNA18042831|2501614
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KLB mRNA20938992
D017313FenretinideFenretinide results in decreased expression of KLB mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of KLB mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of KLB mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of KLB mRNA28628672
C045463leflunomideleflunomide results in decreased expression of KLB mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KLB mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLB mRNA"25620056
D009532NickelNickel results in decreased expression of KLB mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of KLB mRNA16100012
D000073878Palm OilPalm Oil results in decreased expression of KLB mRNA18042831
C016030pantogabpantogab results in decreased expression of KLB mRNA17379144
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of KLB mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of KLB mRNA18301758
D017035PravastatinPravastatin results in decreased expression of KLB mRNA27225895
D017035PravastatinPravastatin results in decreased expression of KLB mRNA27225895
C045950propiconazolepropiconazole results in decreased expression of KLB mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of KLB mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLB mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of KLB mRNA23221170
D012834SilverSilver results in decreased expression of KLB mRNA26014281
C075117squalestatin 1squalestatin 1 results in decreased expression of KLB mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of KLB mRNA27225895
C013698tallowtallow affects the expression of KLB mRNA19680557
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of KLB mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLB mRNA19770486|2188995
C009495titanium dioxidetitanium dioxide results in increased expression of KLB mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KLB mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of KLB mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of KLB mRNA28973697
D014520UrethaneUrethane results in decreased expression of KLB mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of KLB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of KLB mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of KLB gene29154799
C111237vorinostatvorinostat results in decreased expression of KLB mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005104fibroblast growth factor receptor binding-IPI17627937  
GO:0005515protein binding-IPI19059246  
GO:0008422beta-glucosidase activity-IBA21873635  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0017134fibroblast growth factor binding-IPI18829467  19117008  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0005975carbohydrate metabolic process-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0090080positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway-IEA-  
GO:1901657glycosyl compound metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1307965betaKlotho-mediated ligand bindingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190322FGFR4 ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-5654228Phospholipase C-mediated cascade; FGFR4TAS
R-HSA-5654712FRS-mediated FGFR4 signalingTAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654719SHC-mediated cascade:FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654733Negative regulation of FGFR4 signalingTAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28485404Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. (2017 Sep)Jorgenson EMol Psychiatry
28937693Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017 Oct)Clarke TKMol Psychiatry