Gene info: ID 153

Gene: ADRB1

GENE ID: 153

Synonyms: ADRB1R|B1AR|BETA1AR|RHR

Description: adrenoceptor beta 1

Gene type: protein-coding

Location: 10q25.3

dbXrefs: Ensembl:ENSG00000043591 MIM:109630 Vega:OTTHUMG00000019079 UniprotKB:P08588

RefSeq: NG_012187.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.352e-1 (AD) 5.596e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CHST10	0.867
NAB2	0.83
MBOAT7	0.828
DBN1	0.822
TMEM127	0.822
ZNF746	0.82
USP2	0.817
SPATA2	0.814
MAP1S	0.813
DUSP14	0.811

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.528
CTNNA3	-0.496
VRK2	-0.467
OR4F29	-0.466
C5orf64	-0.453
TFPI2	-0.427
TRPV5	-0.422
LRRCC1	-0.419
RAI14	-0.416
ANXA13	-0.414

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00127	Spermine	Small Molecule	71-44-3	Approved\|Nutraceutical	Target
DB00187	Esmolol	Small Molecule	81147-92-4	Approved	Target
DB00195	Betaxolol	Small Molecule	63659-18-7	Approved\|Investigational	Target
DB00221	Isoetarine	Small Molecule	79490-84-9	Approved	Target
DB00248	Cabergoline	Small Molecule	81409-90-7	Approved	Target
DB00264	Metoprolol	Small Molecule	51384-51-1	Approved\|Investigational	Target
DB00335	Atenolol	Small Molecule	29122-68-7	Approved	Target
DB00368	Norepinephrine	Small Molecule	51-41-2	Approved	Target
DB00370	Mirtazapine	Small Molecule	85650-52-8	Approved	Target
DB00373	Timolol	Small Molecule	26839-75-8	Approved	Target
DB00397	Phenylpropanolamine	Small Molecule	14838-15-4	Approved\|Withdrawn	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00489	Sotalol	Small Molecule	3930-20-9	Approved	Target
DB00521	Carteolol	Small Molecule	51781-06-7	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00571	Propranolol	Small Molecule	525-66-6	Approved\|Investigational	Target
DB00598	Labetalol	Small Molecule	36894-69-6	Approved	Target
DB00612	Bisoprolol	Small Molecule	66722-44-9	Approved	Target
DB00668	Epinephrine	Small Molecule	51-43-4	Approved	Target
DB00841	Dobutamine	Small Molecule	34368-04-2	Approved	Target
DB00852	Pseudoephedrine	Small Molecule	90-82-4	Approved	Target
DB00866	Alprenolol	Small Molecule	13655-52-2	Approved\|Withdrawn	Target
DB00871	Terbutaline	Small Molecule	23031-25-6	Approved	Target
DB00938	Salmeterol	Small Molecule	89365-50-4	Approved	Target
DB00960	Pindolol	Small Molecule	13523-86-9	Approved\|Investigational	Target
DB00983	Formoterol	Small Molecule	73573-87-2	Approved\|Investigational	Target
DB01001	Salbutamol	Small Molecule	18559-94-9	Approved	Target
DB01064	Isoprenaline	Small Molecule	7683-59-2	Approved\|Investigational	Target
DB01102	Arbutamine	Small Molecule	128470-16-6	Approved	Target
DB01118	Amiodarone	Small Molecule	1951-25-3	Approved\|Investigational	Target
DB01136	Carvedilol	Small Molecule	72956-09-3	Approved\|Investigational	Target
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Target
DB01182	Propafenone	Small Molecule	54063-53-5	Approved	Target
DB01193	Acebutolol	Small Molecule	37517-30-9	Approved\|Investigational	Target
DB01203	Nadolol	Small Molecule	42200-33-9	Approved	Target
DB01210	Levobunolol	Small Molecule	47141-42-4	Approved	Target
DB01214	Metipranolol	Small Molecule	22664-55-7	Approved	Target
DB01288	Fenoterol	Small Molecule	13392-18-2	Approved\|Investigational	Target
DB01291	Pirbuterol	Small Molecule	38677-81-5	Approved	Target
DB01295	Bevantolol	Small Molecule	59170-23-9	Approved	Target
DB01297	Practolol	Small Molecule	6673-35-4	Approved	Target
DB01359	Penbutolol	Small Molecule	38363-40-5	Approved\|Investigational	Target
DB01363	Ephedra	Small Molecule	-	Approved\|Nutraceutical\|Withdrawn	Target
DB01407	Clenbuterol	Small Molecule	37148-27-9	Approved\|Investigational	Target
DB01580	Oxprenolol	Small Molecule	6452-71-7	Approved	Target
DB01917	Putrescine	Small Molecule	110-60-1	Experimental	Target
DB03566	Spermidine	Small Molecule	124-20-9	Experimental	Target
DB04846	Celiprolol	Small Molecule	56980-93-9	Approved\|Investigational	Target
DB04855	Dronedarone	Small Molecule	141626-36-0	Approved	Target
DB04861	Nebivolol	Small Molecule	118457-14-0	Approved\|Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB06262	Droxidopa	Small Molecule	23651-95-8	Approved\|Investigational	Target
DB08347	4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile	Small Molecule		Experimental	Target
DB08558	2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL	Small Molecule		Experimental	Target
DB08807	Bopindolol	Small Molecule	62658-63-3	Approved	Target
DB08808	Bupranolol	Small Molecule	14556-46-8	Approved	Target
DB09013	Befunolol	Small Molecule	39552-01-7	Experimental	Target
DB09068	Vortioxetine	Small Molecule	508233-74-7	Approved\|Investigational	Target
DB09204	Arotinolol	Small Molecule	68377-92-4	Investigational	Target
DB09351	Levobetaxolol	Small Molecule	93221-48-8	Approved\|Investigational	Target
DB11124	Racepinephrine	Small Molecule	329-65-7	Approved	Target
DB13781	Xamoterol	Small Molecule	81801-12-9	Experimental	Target
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Target
DB00217	Bethanidine	Small Molecule	55-73-2	Approved	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00726	Trimipramine	Small Molecule	739-71-9	Approved	Target
DB01365	Mephentermine	Small Molecule	100-92-5	Approved	Target
DB06726	Bufuralol	Small Molecule	54340-62-4	Experimental\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of ADRB1 mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ADRB1 mRNA"	22698814
C121954	1-(isopropylamino)-3-((4-propenyl-2-methoxy)phenoxy)-2-propanol	1-(isopropylamino)-3-((4-propenyl-2-methoxy)phenoxy)-2-propanol binds to and results in decreased activity of ADRB1 protein	10440531
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of ADRB1 mRNA	25088246
C010076	2-chloroethylamine	2-chloroethylamine analog results in decreased activity of ADRB1 protein	11886792
C097869	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB1 protein"	14730417
C097869	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	"[3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP"	14730417
C097869	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [cyanopindolol binds to ADRB1 protein]"	14730417
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADRB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADRB1 mRNA"	27188386
C095427	A 86929	A 86929 binds to ADRB1 protein	8558425
D000070	Acebutolol	[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000070	Acebutolol	Acebutolol results in increased activity of ADRB1 protein	12761341
D000070	Acebutolol	CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
D000070	Acebutolol	CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein]	12761341
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB1 mRNA]	17585979
D000242	Cyclic AMP	"[3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP"	14730417
D000242	Cyclic AMP	[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000242	Cyclic AMP	ADRB1 protein affects the abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	19419905
D000242	Cyclic AMP	ADRB1 protein polymorphism affects the abundance of Cyclic AMP	14502278
D000242	Cyclic AMP	ADRB1 protein polymorphism affects the reaction [[carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP]	17200720
D000242	Cyclic AMP	ADRB1 protein results in increased abundance of Cyclic AMP	11562432\|1878711
D000242	Cyclic AMP	[Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000242	Cyclic AMP	Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[Bupranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000242	Cyclic AMP	Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417\|1720072
D000242	Cyclic AMP	[carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000242	Cyclic AMP	carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP	15060759
D000242	Cyclic AMP	[CGP 12177 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000242	Cyclic AMP	[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
D000242	Cyclic AMP	CGP 20712A inhibits the reaction [[carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
D000242	Cyclic AMP	CGP 20712A inhibits the reaction [[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
D000242	Cyclic AMP	CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
D000242	Cyclic AMP	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	19419905
D000242	Cyclic AMP	[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Fenoterol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Formoterol Fumarate binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[ICI 118551 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417\|1720072
D000242	Cyclic AMP	Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]	18787115
D000242	Cyclic AMP	[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000242	Cyclic AMP	[Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417\|1720072
D000242	Cyclic AMP	Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[Propranolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Propranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D000242	Cyclic AMP	Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	[Salmeterol Xinafoate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000242	Cyclic AMP	ADRB1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]	18378355
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ADRB1 mRNA	19770486
C412373	AG 1879	AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C412373	AG 1879	AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D000420	Albuterol	Albuterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D000420	Albuterol	Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D000420	Albuterol	Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D000526	Alprenolol	AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D000526	Alprenolol	AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D000526	Alprenolol	AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D000526	Alprenolol	Alprenolol binds to and results in decreased activity of ADRB1 protein	14730417
D000526	Alprenolol	[Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000526	Alprenolol	Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D000526	Alprenolol	Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D000526	Alprenolol	Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]	18787115
D000526	Alprenolol	Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]	18787115
D000526	Alprenolol	Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]	18787115
D000526	Alprenolol	Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]	18787115
D000526	Alprenolol	Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]	18787115
D000526	Alprenolol	Alprenolol results in increased activity of ADRB1 protein	12761341
D000526	Alprenolol	Alprenolol results in increased phosphorylation of ADRB1 protein	18787115
D000526	Alprenolol	[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein	18787115
D000526	Alprenolol	ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D000526	Alprenolol	ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D000526	Alprenolol	ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D000526	Alprenolol	ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D000526	Alprenolol	CGP 20712A affects the reaction [Alprenolol results in increased activity of ADRB1 protein]	12761341
D000526	Alprenolol	HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D000526	Alprenolol	HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D000526	Alprenolol	HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D000526	Alprenolol	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D000526	Alprenolol	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D000526	Alprenolol	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D000526	Alprenolol	Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D000526	Alprenolol	Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]	18787115
D000526	Alprenolol	tyrphostin AG 1478 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D000526	Alprenolol	tyrphostin AG 1478 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D000526	Alprenolol	tyrphostin AG 1478 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D000526	Alprenolol	Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D000526	Alprenolol	Alprenolol binds to and results in decreased activity of ADRB1 protein	10353628
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of ADRB1 mRNA	21298039
D000638	Amiodarone	Amiodarone results in decreased expression of ADRB1 protein	1653643
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ADRB1 mRNA	16483693
C032473	amosulalol	amosulalol binds to and results in decreased activity of ADRB1 protein	6129981
D057911	Angiotensin Receptor Antagonists	ADRB1 protein polymorphism affects the susceptibility to [carvedilol co-treated with Angiotensin Receptor Antagonists]	16475467
C076559	arbutamine	arbutamine binds to and results in increased activity of ADRB1 protein	8723169
D001194	Asbestos	Asbestos results in increased expression of ADRB1 mRNA	22398240
D001262	Atenolol	Atenolol binds to and results in decreased activity of ADRB1 protein	12021574\|8043010
D001262	Atenolol	ADRB1 protein polymorphism affects the susceptibility to Atenolol	22192668
D001262	Atenolol	Atenolol binds to ADRB1 protein	10372227\|8386603
D001262	Atenolol	Atenolol binds to and results in decreased activity of ADRB1 protein	12022239\|1473041
D001262	Atenolol	[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]	17003101
D001262	Atenolol	[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]	17003101
D001262	Atenolol	[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]	17003101
D001262	Atenolol	[Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D001262	Atenolol	[Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine	17003101\|1736960
D001262	Atenolol	[Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D001262	Atenolol	Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D001262	Atenolol	Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]	12761341
D001262	Atenolol	Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D001262	Atenolol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
D001262	Atenolol	Atenolol results in decreased activity of ADRB1 protein	1389726
D001262	Atenolol	Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D001262	Atenolol	Atenolol binds to ADRB1 protein	2462161
D001262	Atenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D001262	Atenolol	Atenolol binds to ADRB1 protein	11483288\|2462161
D001262	Atenolol	Atenolol binds to and results in decreased activity of ADRB1 protein	10894789\|1142557
D001262	Atenolol	Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
D001262	Atenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D001262	Atenolol	Atenolol results in decreased expression of ADRB1 mRNA	17628611
D001262	Atenolol	Atenolol binds to and results in decreased activity of ADRB1 protein	10556671\|1182171
D001262	Atenolol	Atenolol results in decreased activity of ADRB1 protein	14732211\|2773903
D001374	Azacitidine	Azacitidine affects the expression of ADRB1 mRNA	19002953
C058041	B 24-76	B 24-76 results in decreased activity of ADRB1 protein	2974281
C006034	befunolol	befunolol binds to and results in decreased activity of ADRB1 protein	11436944
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of ADRB1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ADRB1 mRNA	22228805\|2261060
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in increased expression of ADRB1 mRNA]	24758408
D004958	Estradiol	Estradiol results in increased expression of ADRB1 mRNA	16202921\|2475840
D015784	Betaxolol	Betaxolol binds to ADRB1 protein	10372227
D015784	Betaxolol	Betaxolol binds to and results in decreased activity of ADRB1 protein	11436944
D015784	Betaxolol	Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]	18596687
D015784	Betaxolol	Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein]	17513029
D015784	Betaxolol	Betaxolol binds to and results in decreased activity of ADRB1 protein	15178407\|1751302
C021148	bevantolol	bevantolol results in decreased expression of ADRB1 mRNA	17628611
D017298	Bisoprolol	Bisoprolol binds to ADRB1 protein	10372227
D017298	Bisoprolol	Bisoprolol binds to and results in decreased activity of ADRB1 protein	11562432\|1473041
D017298	Bisoprolol	[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D017298	Bisoprolol	Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	12535855
D017298	Bisoprolol	Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D017298	Bisoprolol	Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	12535855\|1473041
D017298	Bisoprolol	Bisoprolol results in decreased activity of ADRB1 protein	1389726
D017298	Bisoprolol	Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D017298	Bisoprolol	Bisoprolol binds to and results in decreased activity of ADRB1 protein	2897299
D017298	Bisoprolol	Bisoprolol results in increased expression of ADRB1 mRNA	20668454
D017298	Bisoprolol	Bisoprolol binds to and results in decreased activity of ADRB1 protein	14764656
C006780	bisphenol A	bisphenol A results in decreased expression of ADRB1 mRNA	26063408
C006780	bisphenol A	bisphenol A results in decreased expression of ADRB1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of ADRB1 mRNA	26141625
C057368	BRL 37344	BRL 37344 inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C045916	broxaterol	broxaterol binds to and results in decreased activity of ADRB1 protein	16648137
C045916	broxaterol	broxaterol binds to and results in increased activity of ADRB1 protein mutant form	16648137
C045916	broxaterol	broxaterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C024307	bucindolol	bucindolol results in decreased expression of ADRB1 protein	11392464
C024307	bucindolol	ADRB1 gene polymorphism affects the susceptibility to bucindolol	16844790
D002046	Bupranolol	[Bupranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D002046	Bupranolol	Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D002046	Bupranolol	Bupranolol results in decreased activity of ADRB1 protein	2565296
D002046	Bupranolol	Bupranolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D002087	Butyrates	Butyrates results in increased expression of ADRB1 mRNA	8120022
D002087	Butyrates	Butyrates results in increased expression of ADRB1 protein	8120022
D002104	Cadmium	Cadmium results in decreased expression of ADRB1 mRNA	21694771
D002220	Carbamazepine	Carbamazepine results in increased expression of ADRB1 protein	16478526
D002354	Carteolol	Carteolol binds to and results in decreased activity of ADRB1 protein	11436944
C043211	carvedilol	carvedilol results in decreased activity of ADRB1 protein	2437399
C043211	carvedilol	[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to carvedilol	21395649
C043211	carvedilol	ADRB1 gene polymorphism affects the susceptibility to carvedilol	18075464
C043211	carvedilol	ADRB1 protein polymorphism affects the reaction [[carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP]	17200720
C043211	carvedilol	ADRB1 protein polymorphism affects the susceptibility to carvedilol	14502278\|1720072
C043211	carvedilol	ADRB1 protein polymorphism affects the susceptibility to [carvedilol co-treated with Angiotensin Receptor Antagonists]	16475467
C043211	carvedilol	AG 1879 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C043211	carvedilol	AG 1879 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C043211	carvedilol	AG 1879 inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C043211	carvedilol	ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C043211	carvedilol	ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C043211	carvedilol	ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C043211	carvedilol	ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C043211	carvedilol	carvedilol binds to ADRB1 protein	10372227\|1530622
C043211	carvedilol	carvedilol binds to and results in decreased activity of ADRB1 protein	14730417\|1720072
C043211	carvedilol	[carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417\|1720072
C043211	carvedilol	[carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
C043211	carvedilol	carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	12535855
C043211	carvedilol	carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C043211	carvedilol	carvedilol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	12535855\|1473041
C043211	carvedilol	carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
C043211	carvedilol	carvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]	18787115
C043211	carvedilol	carvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]	18787115
C043211	carvedilol	carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]	18787115
C043211	carvedilol	carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]	18787115
C043211	carvedilol	carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]	18787115
C043211	carvedilol	carvedilol results in increased activity of ADRB1 protein	12761341
C043211	carvedilol	carvedilol results in increased phosphorylation of ADRB1 protein	18787115
C043211	carvedilol	[carvedilol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein	18787115
C043211	carvedilol	CGP 20712A inhibits the reaction [[carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
C043211	carvedilol	CGP 20712A inhibits the reaction [carvedilol results in increased activity of ADRB1 protein]	12761341
C043211	carvedilol	Guanine Nucleotides affects the reaction [carvedilol binds to ADRB1 protein]	1378154
C043211	carvedilol	HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C043211	carvedilol	HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C043211	carvedilol	HBEGF protein promotes the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C043211	carvedilol	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C043211	carvedilol	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C043211	carvedilol	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C043211	carvedilol	Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C043211	carvedilol	Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]	18787115
C043211	carvedilol	tyrphostin AG 1478 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C043211	carvedilol	tyrphostin AG 1478 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C043211	carvedilol	tyrphostin AG 1478 inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C043211	carvedilol	carvedilol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C043211	carvedilol	carvedilol binds to ADRB1 protein	2462161
C043211	carvedilol	carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C043211	carvedilol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
C043211	carvedilol	carvedilol binds to ADRB1 protein	2462161
C043211	carvedilol	carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C043211	carvedilol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
C043211	carvedilol	carvedilol results in increased expression of ADRB1 mRNA	20668454\|2121683
C043211	carvedilol	carvedilol binds to and results in decreased activity of ADRB1 protein	10630826\|1133662
C033394	CGP 12177	Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]	12761341
C033394	CGP 12177	Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	12535855
C033394	CGP 12177	Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	12535855
C033394	CGP 12177	carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	CGP 12177 binds to ADRB1 protein	12535855\|1506075
C033394	CGP 12177	[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP	15060759
C033394	CGP 12177	CGP 12177 binds to and results in decreased activity of ADRB1 protein	14730417
C033394	CGP 12177	[CGP 12177 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
C033394	CGP 12177	[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
C033394	CGP 12177	CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C033394	CGP 12177	CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
C033394	CGP 12177	CGP 12177 results in increased activity of ADRB1 protein	12761341
C033394	CGP 12177	CGP 20712A inhibits the reaction [[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
C033394	CGP 12177	CGP 20712A inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]	12761341
C033394	CGP 12177	Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	"N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB1 protein]"	21870877
C033394	CGP 12177	Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	12535855
C033394	CGP 12177	Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Propranolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]	12761341
C033394	CGP 12177	Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
C033394	CGP 12177	carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	CGP 12177 binds to ADRB1 protein	2462161
C033394	CGP 12177	CGP 20712A inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	CGP 12177 binds to ADRB1 protein	10217540\|1762861
C033394	CGP 12177	CGP 20712A inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	Propranolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C033394	CGP 12177	CGP 12177 binds to and results in decreased activity of ADRB1 protein	9024225
C049763	CGP 20712A	CGP 20712A binds to and results in decreased activity of ADRB1 protein	12606629
C049763	CGP 20712A	CGP 20712A affects the reaction [Alprenolol results in increased activity of ADRB1 protein]	12761341
C049763	CGP 20712A	CGP 20712A affects the reaction [Pindolol results in increased activity of ADRB1 protein]	12761341
C049763	CGP 20712A	CGP 20712A binds to ADRB1 protein	12535855
C049763	CGP 20712A	CGP 20712A binds to and results in decreased activity of ADRB1 protein	11562432\|1473041
C049763	CGP 20712A	[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
C049763	CGP 20712A	CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [[carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [carvedilol results in increased activity of ADRB1 protein]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C049763	CGP 20712A	CGP 20712A inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	10344530
C049763	CGP 20712A	CGP 20712A inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
C049763	CGP 20712A	CGP 20712A inhibits the reaction [Labetalol results in increased activity of ADRB1 protein]	12761341
C049763	CGP 20712A	[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine	12010770
C049763	CGP 20712A	[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Norepinephrine	12010770
C049763	CGP 20712A	CGP 20712A results in decreased activity of ADRB1 protein	19002953
C049763	CGP 20712A	CGP 20712A inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C049763	CGP 20712A	CGP 20712A binds to ADRB1 protein	2462161
C049763	CGP 20712A	CGP 20712A inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C049763	CGP 20712A	CGP 20712A binds to ADRB1 protein	2462161
C049763	CGP 20712A	CGP 20712A binds to and results in decreased activity of ADRB1 protein	10344530\|9718277
C049763	CGP 20712A	CGP 20712A inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
C049763	CGP 20712A	CGP 20712A binds to and results in decreased activity of ADRB1 protein	10577992\|1180499
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of ADRB1 mRNA	17452286
C053708	cicloprolol	cicloprolol binds to and results in decreased activity of ADRB1 protein	2888869
C053708	cicloprolol	cicloprolol binds to and results in decreased activity of ADRB1 protein	2888869
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB1 mRNA]	17585979
D003042	Cocaine	Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]	18596687
D003042	Cocaine	Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein]	17513029
D003042	Cocaine	Cocaine affects the expression of ADRB1 protein	17513029\|1859668
D005576	Colforsin	ADRB1 protein polymorphism affects the susceptibility to Colforsin	14502278
D005576	Colforsin	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	19419905
D005576	Colforsin	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]	19419905
D005576	Colforsin	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]	19419905
D003300	Copper	Copper deficiency results in increased expression of ADRB1 mRNA	26033743
C047975	cyanopindolol	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [cyanopindolol binds to ADRB1 protein]"	14730417
C047975	cyanopindolol	Albuterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	12535855\|1473041
C047975	cyanopindolol	BRL 37344 inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	broxaterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	carvedilol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	12535855\|1473041
C047975	cyanopindolol	CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	CGP 20712A inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	cyanopindolol binds to ADRB1 protein	12535855\|1473041
C047975	cyanopindolol	Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Fenoterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Nebivolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	12535855
C047975	cyanopindolol	Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Propranolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Terbutaline inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C047975	cyanopindolol	Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Bupranolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	carvedilol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	CGP 20712A inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	cyanopindolol binds to ADRB1 protein	11815381
C047975	cyanopindolol	Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Nadolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Propranolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Sotalol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C047975	cyanopindolol	Timolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C014347	decitabine	decitabine results in decreased methylation of ADRB1 promoter	22165287
C014347	decitabine	decitabine results in increased expression of ADRB1 mRNA	22165287
D003671	DEET	DEET results in increased expression of ADRB1 mRNA	27091632
D003671	DEET	[fipronil co-treated with DEET] results in increased expression of ADRB1 mRNA	27091632
D003703	Demecolcine	Demecolcine results in decreased expression of ADRB1 mRNA	23649840
C037293	denopamine	denopamine binds to and results in increased activity of ADRB1 protein	3831029
C037293	denopamine	denopamine binds to and results in increased activity of ADRB1 protein	15608137\|8764276
D003907	Dexamethasone	Dexamethasone results in decreased expression of ADRB1 mRNA	15760667
D004026	Dieldrin	Dieldrin affects the expression of ADRB1 mRNA	18812211
D004041	Dietary Fats	Dietary Fats results in decreased expression of ADRB1 mRNA	22715380
D004041	Dietary Fats	Dietary Fats results in increased expression of ADRB1 mRNA	18721800
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of ADRB1 mRNA	26033743
D004082	Dihydroalprenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Dihydroalprenolol binds to ADRB1 protein	2462161
D004082	Dihydroalprenolol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Nebivolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Dihydroalprenolol binds to ADRB1 protein	2462161
D004082	Dihydroalprenolol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Nebivolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004082	Dihydroalprenolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D004110	Diltiazem	ADRB1 protein polymorphism affects the susceptibility to Diltiazem	22192668
D004280	Dobutamine	ADRB1 gene affects the susceptibility to Dobutamine	21311897
D004280	Dobutamine	ADRB1 gene polymorphism affects the susceptibility to Dobutamine	15564877
D004280	Dobutamine	ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]	20821015
D004280	Dobutamine	ADRB1 protein polymorphism affects the susceptibility to Dobutamine	14502278
D004280	Dobutamine	AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D004280	Dobutamine	AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D004280	Dobutamine	AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D004280	Dobutamine	ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D004280	Dobutamine	ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D004280	Dobutamine	ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D004280	Dobutamine	ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D004280	Dobutamine	Dobutamine binds to and results in increased activity of ADRB1 protein	11753577\|1602491
D004280	Dobutamine	Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D004280	Dobutamine	Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]	18787115
D004280	Dobutamine	Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]	18787115
D004280	Dobutamine	Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]	18787115
D004280	Dobutamine	HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D004280	Dobutamine	HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D004280	Dobutamine	HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D004280	Dobutamine	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D004280	Dobutamine	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D004280	Dobutamine	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D004280	Dobutamine	Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D004280	Dobutamine	Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]	18787115
D004280	Dobutamine	tyrphostin AG 1478 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
D004280	Dobutamine	tyrphostin AG 1478 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
D004280	Dobutamine	tyrphostin AG 1478 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D004280	Dobutamine	Dobutamine binds to and results in increased activity of ADRB1 protein	10192281
D004280	Dobutamine	[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 mRNA	19719783
D004280	Dobutamine	[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 protein	19719783
D004280	Dobutamine	Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D004280	Dobutamine	Oxygen deficiency results in increased susceptibility to [Dobutamine binds to and results in increased activity of ADRB1 protein]	10192281
D004280	Dobutamine	Dobutamine binds to and results in increased activity of ADRB1 protein	10630826\|1505228
D017292	Doxazosin	Doxazosin results in increased expression of ADRB1 protein	18084315
D004317	Doxorubicin	ADRB1 affects the susceptibility to Doxorubicin	16458323
D004317	Doxorubicin	Doxorubicin results in decreased expression of ADRB1 mRNA	15353854
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal binds to and results in decreased activity of ADRB1 protein"	11425575
D004656	Enalapril	Enalapril results in increased expression of ADRB1 protein	7586371
D015773	Enalaprilat	Enalaprilat affects the expression of ADRB1 protein	9260993
D004837	Epinephrine	Epinephrine binds to and results in increased activity of ADRB1 protein	14730417
D004837	Epinephrine	[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417
D004837	Epinephrine	Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D004837	Epinephrine	Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D004837	Epinephrine	[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine	12010770
D004837	Epinephrine	Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
C036604	esmolol	esmolol binds to and results in decreased activity of ADRB1 protein	2900259
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ADRB1 mRNA	23550701
D005039	Etilefrine	Etilefrine binds to and results in increased activity of ADRB1 protein	788908
D005280	Fenoterol	Fenoterol binds to and results in increased activity of ADRB1 protein	14730417
D005280	Fenoterol	[Fenoterol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417
D005280	Fenoterol	Fenoterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C112517	ferulinolol	ferulinolol binds to and results in decreased activity of ADRB1 protein	9593075
C112517	ferulinolol	ferulinolol binds to ADRB1 protein	9593075
C082360	fipronil	[fipronil co-treated with DEET] results in increased expression of ADRB1 mRNA	27091632
C082360	fipronil	fipronil results in increased expression of ADRB1 mRNA	27091632
D005557	Formaldehyde	Formaldehyde results in decreased expression of ADRB1 mRNA	23649840
D000068759	Formoterol Fumarate	Formoterol Fumarate binds to and results in increased activity of ADRB1 protein	14730417
D000068759	Formoterol Fumarate	[Formoterol Fumarate binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417
D000068759	Formoterol Fumarate	Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C069837	fullerene C60	fullerene C60 results in increased expression of ADRB1 mRNA	19167457
D006150	Guanine Nucleotides	Guanine Nucleotides affects the reaction [carvedilol binds to ADRB1 protein]	1378154
C056599	icariin	icariin results in increased expression of ADRB1 mRNA	16490167
C026777	ICI 118551	ICI 118551 binds to and results in decreased activity of ADRB1 protein	14730417
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
C026777	ICI 118551	ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
C026777	ICI 118551	[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 mRNA	19719783
C026777	ICI 118551	[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 protein	19719783
C026777	ICI 118551	ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	9260993
C025716	ICI 89406	ICI 89406 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
C025716	ICI 89406	ICI 89406 binds to and results in decreased activity of ADRB1 protein	17628611
C025716	ICI 89406	ICI 89406 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
C025716	ICI 89406	ICI 89406 binds to and results in decreased activity of ADRB1 protein	12732361
D019329	Idazoxan	[Imipramine co-treated with Idazoxan] results in decreased activity of ADRB1 protein	2868116
D007099	Imipramine	[Imipramine co-treated with Idazoxan] results in decreased activity of ADRB1 protein	2868116
D007099	Imipramine	[Imipramine co-treated with Yohimbine] results in decreased activity of ADRB1 protein	2868116
D007099	Imipramine	Imipramine results in decreased activity of ADRB1 protein	2868116
D020120	Iodocyanopindolol	Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	CGP 20712A inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	10344530
D020120	Iodocyanopindolol	Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	ICI 89406 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Iodocyanopindolol binds to ADRB1 protein	10344530\|8096834
D020120	Iodocyanopindolol	Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	soterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	9260993
D020120	Iodocyanopindolol	ICI 89406 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Iodocyanopindolol binds to ADRB1 protein	8096834\|9260993
D020120	Iodocyanopindolol	Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	soterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D020120	Iodocyanopindolol	Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D015056	1-Methyl-3-isobutylxanthine	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	19419905
D015056	1-Methyl-3-isobutylxanthine	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]	19419905
D015056	1-Methyl-3-isobutylxanthine	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]	19419905
D007545	Isoproterenol	ADRB1 protein polymorphism affects the susceptibility to Isoproterenol	14502278
D007545	Isoproterenol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
D007545	Isoproterenol	carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
D007545	Isoproterenol	CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
D007545	Isoproterenol	CGP 20712A inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
D007545	Isoproterenol	Isoproterenol binds to and results in increased activity of ADRB1 protein	14730417\|1562748
D007545	Isoproterenol	[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417\|1720072
D007545	Isoproterenol	Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D007545	Isoproterenol	Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D007545	Isoproterenol	Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein]	18787115
D007545	Isoproterenol	Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]	18787115
D007545	Isoproterenol	Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]	18787115
D007545	Isoproterenol	Isoproterenol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]	18787115
D007545	Isoproterenol	Isoproterenol results in increased activity of ADRB1 protein	12761341
D007545	Isoproterenol	Isoproterenol results in increased phosphorylation of ADRB1 protein	18787115
D007545	Isoproterenol	Propranolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
D007545	Isoproterenol	[ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol	11159692
D007545	Isoproterenol	Isoproterenol results in decreased expression of ADRB1	12963636
D007545	Isoproterenol	Isoproterenol results in decreased expression of ADRB1 mRNA	17350036\|2000320
D007545	Isoproterenol	ADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein]	18378355
D007545	Isoproterenol	ADRB1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]	18378355
D007545	Isoproterenol	AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]	16731636
D007545	Isoproterenol	Isoproterenol binds to and results in increased activity of ADRB1 protein	8723169
D007545	Isoproterenol	Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D007545	Isoproterenol	Isoproterenol results in decreased expression of ADRB1 mRNA	1312942\|16731636
D007545	Isoproterenol	Isoproterenol results in increased uptake of ADRB1 protein	18194989
D007545	Isoproterenol	Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]	1312942
D007545	Isoproterenol	Isoproterenol binds to and results in increased activity of ADRB1 protein	10898105\|1571035
C466918	KMUP 880602	KMUP 880602 binds to and results in decreased activity of ADRB1 protein	12021574
D007741	Labetalol	Labetalol binds to and results in decreased activity of ADRB1 protein	12021574
D007741	Labetalol	CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	12761341
D007741	Labetalol	CGP 20712A inhibits the reaction [Labetalol results in increased activity of ADRB1 protein]	12761341
D007741	Labetalol	[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D007741	Labetalol	Labetalol results in decreased activity of ADRB1 protein	2567112
D007741	Labetalol	Labetalol results in increased activity of ADRB1 protein	12761341
D007741	Labetalol	Labetalol binds to ADRB1 protein	2462161
D007741	Labetalol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D007741	Labetalol	Labetalol binds to ADRB1 protein	11483288\|2462161
D007741	Labetalol	Labetalol binds to and results in decreased activity of ADRB1 protein	11425575
D007741	Labetalol	Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
D007741	Labetalol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of ADRB1 mRNA"	21543636
D008727	Methotrexate	Methotrexate results in decreased expression of ADRB1 mRNA	24449571
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ADRB1 mRNA	23649840
D008790	Metoprolol	Metoprolol binds to and results in decreased activity of ADRB1 protein	9593075
D008790	Metoprolol	ADRB1 gene affects the susceptibility to Metoprolol	21311897
D008790	Metoprolol	ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]	20821015
D008790	Metoprolol	ADRB1 gene polymorphism affects the susceptibility to Metoprolol	12844134\|1586411
D008790	Metoprolol	[ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol	17496726
D008790	Metoprolol	ADRB1 protein polymorphism affects the susceptibility to Metoprolol	22192668
D008790	Metoprolol	Metoprolol binds to ADRB1 protein	10372227
D008790	Metoprolol	Metoprolol binds to and results in decreased activity of ADRB1 protein	11562432\|1473041
D008790	Metoprolol	[Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D008790	Metoprolol	Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D008790	Metoprolol	Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D008790	Metoprolol	Metoprolol results in decreased activity of ADRB1 protein	1389726
D008790	Metoprolol	Metoprolol results in increased expression of ADRB1 mRNA	20675662
D008790	Metoprolol	Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D008790	Metoprolol	Metoprolol binds to ADRB1 protein	9593075
D008790	Metoprolol	Metoprolol binds to and results in increased activity of ADRB1 protein	20590644
D008790	Metoprolol	Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]	1312942
D008790	Metoprolol	Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein]	18703049
D008790	Metoprolol	Metoprolol results in decreased methylation of ADRB1 promoter	22165287
D008790	Metoprolol	Metoprolol results in increased expression of ADRB1 mRNA	22165287
D008790	Metoprolol	Metoprolol results in increased expression of ADRB1 protein	18703049
D008790	Metoprolol	GRK5 protein affects the reaction [Metoprolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]]	22888001
D008790	Metoprolol	Metoprolol binds to and results in decreased activity of ADRB1 protein	11577025\|1312942
D008790	Metoprolol	Metoprolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]	22888001
D008790	Metoprolol	Metoprolol results in decreased activity of ADRB1 protein	12954926\|9431853
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C568515	N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide	"N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB1 protein]"	21870877
C435583	N-(4-(2-hydroxy-3-(2-methoxy-1-oxyethylaminobenzene)propoxy))benzaldehyde	N-(4-(2-hydroxy-3-(2-methoxy-1-oxyethylaminobenzene)propoxy))benzaldehyde binds to ADRB1 protein	11483288
D009248	Nadolol	Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D009248	Nadolol	Nadolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D009248	Nadolol	Nadolol binds to and results in decreased activity of ADRB1 protein	11577025\|1762277
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ADRB1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ADRB1 mRNA"	25554681
D000068577	Nebivolol	Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	12535855
D000068577	Nebivolol	Nebivolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	12535855
D000068577	Nebivolol	Nebivolol binds to ADRB1 protein	2462161
D000068577	Nebivolol	Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
D000068577	Nebivolol	Nebivolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D000068577	Nebivolol	Nebivolol binds to ADRB1 protein	2462161
D000068577	Nebivolol	Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
D000068577	Nebivolol	Nebivolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D000068577	Nebivolol	Nebivolol binds to and results in decreased activity of ADRB1 protein	1383620\|17324145
D009532	Nickel	Nickel results in decreased expression of ADRB1 mRNA	24768652\|2558310
D009538	Nicotine	[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]	17003101
D009538	Nicotine	[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]	17003101
D009538	Nicotine	[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]	17003101
D009538	Nicotine	[Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine	17003101\|1736960
D009538	Nicotine	Nicotine results in increased expression of ADRB1 mRNA	17369603
D009638	Norepinephrine	Norepinephrine results in increased activity of ADRB1 protein	10344530
D009638	Norepinephrine	Norepinephrine results in decreased expression of ADRB1 mRNA	11392464
D009638	Norepinephrine	Norepinephrine results in decreased expression of ADRB1 protein	11392464
D009638	Norepinephrine	Norepinephrine binds to and results in increased activity of ADRB1 protein	10344530\|1473041
D009638	Norepinephrine	[Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	14730417\|1720072
D009638	Norepinephrine	Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D009638	Norepinephrine	Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D009638	Norepinephrine	Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein]	17200720
D009638	Norepinephrine	Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]	10344530
D009638	Norepinephrine	Propranolol inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRB1 protein]	17200720
D009638	Norepinephrine	[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Norepinephrine	12010770
D009638	Norepinephrine	Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D009655	Octopamine	Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]	10344530
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of ADRB1 mRNA	20184727
D010096	Oxprenolol	Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D010100	Oxygen	Oxygen deficiency results in increased expression of ADRB1 protein	10192281
D010100	Oxygen	Oxygen deficiency results in increased susceptibility to [Dobutamine binds to and results in increased activity of ADRB1 protein]	10192281
D010643	Phenoxybenzamine	Phenoxybenzamine binds to and results in decreased activity of ADRB1 protein	11886792
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADRB1 mRNA"	27188386
D010869	Pindolol	Pindolol binds to and results in decreased activity of ADRB1 protein	2888869
D010869	Pindolol	CGP 20712A affects the reaction [Pindolol results in increased activity of ADRB1 protein]	12761341
D010869	Pindolol	Pindolol binds to and results in decreased activity of ADRB1 protein	14730417
D010869	Pindolol	[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D010869	Pindolol	Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D010869	Pindolol	Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D010869	Pindolol	Pindolol results in increased activity of ADRB1 protein	12761341
D010869	Pindolol	Pindolol results in increased expression of ADRB1 protein	2175014
D010869	Pindolol	Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D010869	Pindolol	Pindolol binds to ADRB1 protein	2462161
D010869	Pindolol	Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
D010869	Pindolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D010869	Pindolol	Pindolol binds to ADRB1 protein	2462161
D010869	Pindolol	Pindolol binds to and results in decreased activity of ADRB1 protein	2888869
D010869	Pindolol	Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
D010869	Pindolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D010869	Pindolol	Pindolol binds to and results in decreased activity of ADRB1 protein	2205704
D010936	Plant Extracts	Plant Extracts results in decreased expression of ADRB1 mRNA	23557933
D011188	Potassium	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]	19419905
D011294	Prenalterol	Prenalterol binds to and results in increased activity of ADRB1 protein	6145533
D011405	Propafenone	Propafenone binds to and results in decreased activity of ADRB1 protein	6141285
C005556	propionaldehyde	propionaldehyde results in increased expression of ADRB1 mRNA	26079696
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB1 protein	12021574\|8043010
D011433	Propranolol	Propranolol results in decreased activity of ADRB1 protein	2437399
D011433	Propranolol	ADRB1 protein polymorphism affects the susceptibility to Propranolol	14502278
D011433	Propranolol	Propranolol binds to ADRB1 protein	10372227
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB1 protein	10952688\|1473041
D011433	Propranolol	[Propranolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D011433	Propranolol	[Propranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	12761341
D011433	Propranolol	Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D011433	Propranolol	Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]	18787115
D011433	Propranolol	Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D011433	Propranolol	Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]	18787115
D011433	Propranolol	Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D011433	Propranolol	Propranolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]	12761341
D011433	Propranolol	Propranolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D011433	Propranolol	Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D011433	Propranolol	Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]	18787115
D011433	Propranolol	Propranolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]	12761341
D011433	Propranolol	Propranolol inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRB1 protein]	17200720
D011433	Propranolol	Propranolol results in increased activity of ADRB1 protein	12761341
D011433	Propranolol	Propranolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
D011433	Propranolol	Propranolol binds to ADRB1 protein	2462161
D011433	Propranolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D011433	Propranolol	Propranolol binds to ADRB1 protein	11483288\|2462161
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB1 protein	11425575
D011433	Propranolol	Propranolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]	2462161
D011433	Propranolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]	2462161
D011433	Propranolol	Propranolol results in increased expression of ADRB1 mRNA	20668454
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB1 protein	10556671\|1264237
D011700	Putrescine	Putrescine binds to and results in increased activity of ADRB1 protein	20885010
D012110	Reserpine	Reserpine results in increased expression of ADRB1 mRNA	1336118
D012110	Reserpine	Reserpine results in increased expression of ADRB1 protein	1336118
D012110	Reserpine	Reserpine results in increased stability of ADRB1 mRNA	1336118
C059514	resveratrol	resveratrol results in decreased expression of ADRB1 mRNA	22610192
C021828	Revalor	Revalor results in decreased expression of ADRB1 mRNA	24987078
C018420	Ro 363	Ro 363 binds to and results in increased activity of ADRB1 protein	11907156
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate binds to and results in decreased activity of ADRB1 protein	14730417
D000068299	Salmeterol Xinafoate	[Salmeterol Xinafoate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	14730417
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D019821	Simvastatin	Simvastatin results in increased expression of ADRB1 mRNA	19262002
D019821	Simvastatin	Simvastatin results in increased expression of ADRB1 protein	19262002
D012969	Sodium Fluoride	ADRB1 protein polymorphism affects the susceptibility to Sodium Fluoride	14502278
D012999	Soman	Soman results in increased expression of ADRB1 mRNA	19281266
D053260	Soot	Soot results in decreased expression of ADRB1 mRNA	26551751
D013015	Sotalol	Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D013015	Sotalol	Sotalol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C100252	soterenol	soterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
C100252	soterenol	soterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D013095	Spermidine	Spermidine binds to ADRB1 protein	20885010
D013096	Spermine	Spermine binds to ADRB1 protein	20885010
D013311	Streptozocin	Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein]	18703049
D013311	Streptozocin	Streptozocin results in decreased expression of ADRB1 protein	18703049
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ADRB1 mRNA	10217540\|1109063
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ADRB1 protein	10217540
D013726	Terbutaline	Terbutaline binds to and results in decreased activity of ADRB1 protein	16648137
D013726	Terbutaline	Terbutaline binds to and results in increased activity of ADRB1 protein mutant form	16648137
D013726	Terbutaline	Terbutaline inhibits the reaction [cyanopindolol binds to ADRB1 protein]	14730417
D013726	Terbutaline	Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D013726	Terbutaline	Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]	8096834
D013739	Testosterone	Testosterone results in increased expression of ADRB1 protein	18157169
D013999	Timolol	Timolol binds to and results in decreased activity of ADRB1 protein	11436944
D013999	Timolol	Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	15060759
D013999	Timolol	Timolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]	11815381
C009495	titanium dioxide	titanium dioxide results in decreased expression of ADRB1 mRNA	23557971
C052035	trandolapril	trandolapril results in increased expression of ADRB1 protein	7586371
C012589	trichostatin A	trichostatin A results in increased expression of ADRB1 mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of ADRB1 mRNA	15901671
C057693	troglitazone	troglitazone results in decreased expression of ADRB1 mRNA	28973697
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]	18787115
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]	18787115
D014635	Valproic Acid	Valproic Acid affects the expression of ADRB1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of ADRB1 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of ADRB1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of ADRB1 protein	16478526
D014635	Valproic Acid	Valproic Acid results in increased expression of ADRB1 mRNA	15901671
C088562	vaninolol	vaninolol binds to and results in decreased activity of ADRB1 protein	8043010
D014700	Verapamil	ADRB1 protein polymorphism affects the susceptibility to Verapamil	22192668
D014750	Vincristine	Vincristine results in decreased expression of ADRB1 mRNA	23649840
C557874	vortioxetine	vortioxetine binds to ADRB1 protein	21486038
D017307	Xamoterol	Xamoterol binds to and results in decreased activity of ADRB1 protein	2888869
D017307	Xamoterol	Xamoterol binds to and results in increased activity of ADRB1 protein	12606629
D017307	Xamoterol	Xamoterol binds to and results in increased activity of ADRB1 protein	11562432
D017307	Xamoterol	Xamoterol binds to and results in decreased activity of ADRB1 protein	2888869
D017307	Xamoterol	Xamoterol binds to and results in increased activity of ADRB1 protein	2572264
C064876	YM 16151-1	YM 16151-1 results in decreased activity of ADRB1 protein	8100704
C106124	YM 430	YM 430 binds to and results in decreased activity of ADRB1 protein	9074945
D015016	Yohimbine	[Imipramine co-treated with Yohimbine] results in decreased activity of ADRB1 protein	2868116
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of ADRB1 mRNA	27185063

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004935	adrenergic receptor activity	-	IBA	21873635
GO:0004939	beta-adrenergic receptor activity	-	TAS	8892658
GO:0004940	beta1-adrenergic receptor activity	-	IBA	21873635
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	IDA	12391161
GO:0005515	protein binding	-	IPI	11526121 12391161 16316992 22723743 23381222
GO:0030165	PDZ domain binding	-	IPI	11526121
GO:0031694	alpha-2A adrenergic receptor binding	-	IPI	12529373
GO:0046982	protein heterodimerization activity	-	IPI	12529373
GO:0051379	epinephrine binding	-	IBA	21873635
GO:0051380	norepinephrine binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001659	temperature homeostasis	-	IBA	21873635
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	-	IBA	21873635
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	-	IEA	-
GO:0002024	diet induced thermogenesis	-	IEA	-
GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007190	activation of adenylate cyclase activity	-	TAS	10212248
GO:0007267	cell-cell signaling	-	IBA	21873635
GO:0009409	response to cold	-	IEA	-
GO:0031649	heat generation	-	IEA	-
GO:0040015	negative regulation of multicellular organism growth	-	IEA	-
GO:0042596	fear response	-	IEA	-
GO:0043547	positive regulation of GTPase activity	-	IDA	12391161
GO:0043950	positive regulation of cAMP-mediated signaling	-	IDA	12391161
GO:0050873	brown fat cell differentiation	-	IEA	-
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	-	IBA	21873635
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	-	IDA	12391161 12529373

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005769	early endosome	-	IDA	21540189
GO:0005886	plasma membrane	-	IDA	11526121 21540189
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	10212248

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04144	Endocytosis
hsa04540	Gap junction
hsa04970	Salivary secretion
hsa05414	Dilated cardiomyopathy

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390696	Adrenoceptors	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24884436	Chronic alcohol consumption from adolescence-to-adulthood in mice--hypothalamic gene expression changes in the dilated cardiomyopathy signaling pathway. (2014 May 9)	Zou H	BMC Neurosci
29549925	The Association of ADRB1 and CYP2D6 Polymorphisms With Antihypertensive Effects and Analysis of Their Contribution to Hypertension Risk. (2018 Mar)	Chen L	Am J Med Sci
23202124	New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. (2013 Jan)	Horikoshi M	Nat Genet
15469403	Pharmacogenomics and drug response in cardiovascular disorders. (2004 Oct)	Siest G	Pharmacogenomics
24225246	[Associations between G1165C and A145G polymorphism of beta1-adrenoceptor and resting heart rate in the Northern Han Chinese]. (2013 Aug)	Wang H	Zhonghua Xin Xue Guan Bing Za Zhi
16907703	Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. (2006 Sep)	Wilk JB	Ann Hum Genet