Gene: SRFBP1

153443
BUD22|P49|Rlb1|STRAP|p49/STRAP
serum response factor binding protein 1
protein-coding
5q23.1
Ensembl:ENSG00000151304 MIM:610479 Vega:OTTHUMG00000162970 UniprotKB:Q8NEF9
NC_000005.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.143e-1 (AD)  4.864e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4496732chr5:121982225 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05637113chr5:121307216SRFBP11.990e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM120.859
NRAS0.846
HAUS20.824
TMF10.822
SCAF110.817
DDX180.815
NMD30.814
SEC24A0.812
RBM270.81
UTP150.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.408
OR4F29-0.371
MMP23B-0.271
GAGE10-0.262
ANP32C-0.257
FAM186A-0.252
HIGD1B-0.248
CLDN9-0.24
SLC7A9-0.232
NTN5-0.225

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SRFBP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of SRFBP1 mRNA"20406850
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SRFBP1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SRFBP1 mRNA17562736
D001280AtrazineAtrazine results in increased expression of SRFBP1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRFBP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SRFBP1 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of SRFBP1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of SRFBP1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRFBP1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRFBP1 protein24527689
D016572CyclosporineCyclosporine results in increased expression of SRFBP1 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of SRFBP1 mRNA24921660
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SRFBP1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of SRFBP1 mRNA28302478
D005485FlutamideFlutamide results in increased expression of SRFBP1 mRNA24136188
D017313FenretinideFenretinide results in increased expression of SRFBP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SRFBP1 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of SRFBP1 mRNA21396975
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SRFBP1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SRFBP1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of SRFBP1 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SRFBP1 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SRFBP1 mRNA29191790
D010634PhenobarbitalPhenobarbital affects the expression of SRFBP1 mRNA19159669
C016104sodium bichromatesodium bichromate results in increased expression of SRFBP1 mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRFBP1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRFBP1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRFBP1 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of SRFBP1 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SRFBP1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of SRFBP1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SRFBP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0030490maturation of SSU-rRNA-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:003068690S preribosome-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal