Gene info: ID 1535

Gene: CYBA

GENE ID: 1535

Synonyms: p22-PHOX

Description: cytochrome b-245 alpha chain

Gene type: protein-coding

Location: 16q24.2

dbXrefs: Ensembl:ENSG00000051523 MIM:608508 Vega:OTTHUMG00000173320 UniprotKB:P13498

RefSeq: NG_007291.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 13

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.559e-1 (AD) 7.107e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPI1	0.936
GPSM3	0.928
ARPC1B	0.922
TYROBP	0.916
FCER1G	0.91
ABI3	0.907
S100A11	0.903
CMTM7	0.903
RHBDF2	0.903
LAPTM5	0.901

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ST6GAL2	-0.531
NEUROD6	-0.52
MARCH4	-0.493
PPEF1	-0.491
ABCC12	-0.489
SLC7A4	-0.476
KCNB2	-0.472
CALHM1	-0.462
KCNIP3	-0.46
XKR4	-0.457

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00514	Dextromethorphan	Small Molecule	125-71-3	Approved	Target

ID	Drug Name	Action	PubMed
C549500	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea inhibits the reaction [AGT protein modified form results in increased expression of CYBA mRNA]	27678262
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of CYBA mRNA"	19162173
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CYBA mRNA"	19114083
C014970	2-aminodiphenyl	2-aminodiphenyl results in increased expression of CYBA protein	22288910
C014970	2-aminodiphenyl	CYBA mutant form inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]	22288910
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of CYBA mRNA]	23978445
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CYBA mRNA"	25380136
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	23270704
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	23270704
C408690	4-cresol sulfate	4-cresol sulfate results in increased expression of CYBA mRNA	23325087
C408690	4-cresol sulfate	4-cresol sulfate results in increased expression of CYBA protein	23325087
C408690	4-cresol sulfate	CYBA protein promotes the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein]	23325087
C408690	4-cresol sulfate	CYBA protein results in increased susceptibility to 4-cresol sulfate	23325087
C408690	4-cresol sulfate	Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of CYBA mRNA]	23325087
C408690	4-cresol sulfate	4-cresol sulfate results in increased expression of CYBA protein	23325087
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA protein]]"	17916771
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYBA mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of CYBA mRNA	25704631
D000082	Acetaminophen	Acetaminophen affects the expression of CYBA mRNA	17562736
C056165	acetovanillone	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
C056165	acetovanillone	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	23270704
C056165	acetovanillone	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	23270704
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]	21195169
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CYBA mRNA	27153756
C031143	AICA ribonucleotide	AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]	21195169
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin affects the expression of CYBA mRNA	28522335
D000602	Amino Acids, Peptides, and Proteins	"Amino Acids, Peptides, and Proteins results in decreased expression of CYBA mRNA"	15085064
D017311	Amlodipine	Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]	21107329
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CYBA mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CYBA mRNA	24449571
D001151	Arsenic	CYBA gene polymorphism affects the susceptibility to Arsenic	16076760
D001151	Arsenic	CYBA gene SNP affects the susceptibility to Arsenic	26220686
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CYBA mRNA	15070760\|2775016
C015001	arsenite	arsenite results in increased expression of CYBA mRNA	10720412
C015001	arsenite	CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]	10720412
D017638	Asbestos, Crocidolite	"CYBA protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	18403674
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	25305479
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	25305479
D001241	Aspirin	Aspirin inhibits the reaction [AGT protein modified form results in increased expression of CYBA mRNA]	22306536
D000069059	Atorvastatin Calcium	Atorvastatin Calcium inhibits the reaction [sodium arsenite results in increased expression of CYBA mRNA]	25218292
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to CYBA promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CYBA mRNA	19770486\|2264161
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYBA mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of CYBA mRNA	19167446
D004958	Estradiol	Estradiol affects the expression of CYBA mRNA	16195479\|1668458
D001629	Bezafibrate	Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA]	11172467
D001629	Bezafibrate	Bezafibrate results in decreased expression of CYBA mRNA	11172467
D001629	Bezafibrate	Bezafibrate inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]	12967931
C006780	bisphenol A	bisphenol A affects the expression of CYBA mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased methylation of CYBA promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of CYBA mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Dietary Fats] results in increased expression of CYBA mRNA	25112833
D000069286	Bortezomib	Bortezomib results in decreased expression of CYBA mRNA	20977926
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of CYBA mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CYBA protein	21195169
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of CYBA mRNA	18804290
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]	21195169
D019256	Cadmium Chloride	AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]	21195169
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CYBA protein	21195169
D019256	Cadmium Chloride	PTEN inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]	21195169
D019256	Cadmium Chloride	Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]	21195169
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CYBA mRNA]	20360939
C081643	candesartan	candesartan results in decreased expression of CYBA protein	18551021
C081643	candesartan	Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]	21107329
C081643	candesartan	candesartan inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]	16139267
C081643	candesartan	candesartan results in decreased expression of CYBA	21107329
C081643	candesartan	candesartan results in decreased expression of CYBA mRNA	16685210
C081643	candesartan	Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA]	21107329
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYBA mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYBA mRNA	17854599
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of CYBA mRNA	23650126
C100187	chloropicrin	chloropicrin affects the expression of CYBA mRNA	26352163
C100187	chloropicrin	chloropicrin results in decreased expression of CYBA mRNA	28476498
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYBA mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of CYBA protein	21742780
D002994	Clofibrate	Clofibrate inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]	23422569
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CYBA protein	16507596
D003042	Cocaine	Cocaine results in increased expression of CYBA protein	18952886
C513821	CPU0213	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]	18594475
D003471	Cuprizone	Cuprizone results in increased expression of CYBA mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYBA mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of CYBA mRNA	12352326
D016572	Cyclosporine	Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]	12352326
D003561	Cytarabine	Cytarabine results in decreased expression of CYBA mRNA	21198554
D003630	Daunorubicin	Daunorubicin results in increased expression of CYBA protein	21054405
D003630	Daunorubicin	telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein]	21054405
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CYBA mRNA	23914054
C526360	dechlorane plus	dechlorane plus results in increased expression of CYBA mRNA	22913625
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in increased expression of CYBA mRNA	27634381
D003687	Dehydroepiandrosterone	Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]	27634381
D003687	Dehydroepiandrosterone	Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]	27634381
D003687	Dehydroepiandrosterone	Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]	27634381
D003687	Dehydroepiandrosterone	Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]	27634381
D064791	Desoxycorticosterone Acetate	CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA]	27678262
D064791	Desoxycorticosterone Acetate	[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA	27678262
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of CYBA protein	20637373
D003976	Diazinon	Diazinon results in increased methylation of CYBA gene	22964155
D002945	Cisplatin	Cisplatin results in increased expression of CYBA mRNA	27594783
D002945	Cisplatin	[Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA	24865317
D002945	Cisplatin	Cisplatin results in decreased expression of CYBA mRNA	24865317
D002945	Cisplatin	Cisplatin results in increased expression of CYBA mRNA	21151649
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of CYBA mRNA	25386960
D004008	Diclofenac	Diclofenac results in increased expression of CYBA mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in decreased expression of CYBA mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of CYBA mRNA	22609946
D004041	Dietary Fats	[bisphenol A co-treated with Dietary Fats] results in increased expression of CYBA mRNA	25112833
D004052	Diethylnitrosamine	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CYBA mRNA]	20360939
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CYBA mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CYBA mRNA	20360939
D004147	Dioxins	Dioxins affects the expression of CYBA mRNA	20463971
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA mRNA]	25726414
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA protein]	25726414
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in decreased expression of CYBA mRNA	11172467
D004656	Enalapril	Enalapril results in decreased expression of CYBA protein	20720404\|2503705
D004656	Enalapril	[paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein	20720404
C414690	eplerenone	eplerenone results in decreased expression of CYBA mRNA	17324946
C414690	eplerenone	[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA	17324946
D000431	Ethanol	Ethanol results in increased expression of CYBA protein	22872060
D000431	Ethanol	[sodium arsenite co-treated with Ethanol] results in increased expression of CYBA protein	22872060
D000431	Ethanol	sodium arsenite promotes the reaction [Ethanol results in increased expression of CYBA protein]	22872060
D000431	Ethanol	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of CYBA mRNA]	23978445
D000431	Ethanol	Ethanol results in increased expression of CYBA mRNA	20026259\|2397844
D000431	Ethanol	SB 203580 inhibits the reaction [Ethanol results in increased expression of CYBA mRNA]	23978445
D000431	Ethanol	Ethanol results in decreased expression of CYBA mRNA	17920746
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CYBA mRNA	17555576\|1794274
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CYBA mRNA	17557909\|2409603
C540355	fenamidone	fenamidone results in increased expression of CYBA mRNA	27029645
D005419	Flavonoids	Flavonoids inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]	23994555
D005419	Flavonoids	Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of CYBA mRNA]]	23994555
D005419	Flavonoids	Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of CYBA protein]]	23994555
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYBA mRNA	20938992
C069837	fullerene C60	fullerene C60 results in decreased expression of CYBA mRNA	19167457
C039281	furan	furan results in decreased methylation of CYBA gene	27387713
C039281	furan	furan results in increased expression of CYBA mRNA	27387713
D005688	Galactosamine	"[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CYBA protein"	28887131
D005688	Galactosamine	"ONO 1301 inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CYBA protein]"	28887131
D019833	Genistein	Genistein results in decreased expression of CYBA mRNA	16705744
D019833	Genistein	Genistein results in decreased expression of CYBA mRNA	24967385
D005839	Gentamicins	Gentamicins results in decreased expression of CYBA mRNA	22061828
D005839	Gentamicins	Gentamicins results in increased expression of CYBA mRNA	22061828
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein]	29037473
D005944	Glucosamine	Glucosamine results in decreased expression of CYBA mRNA	18077487
D005947	Glucose	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA protein]]"	17916771
D005947	Glucose	Glucose results in increased expression of CYBA protein	17916771\|1808807
D005947	Glucose	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of CYBA protein]	18088078
D005947	Glucose	rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA protein]	17916771
D005947	Glucose	CYBA protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]	22245600
D005947	Glucose	CYBA protein promotes the reaction [Glucose results in increased expression of FN1 protein]	22245600
D005947	Glucose	Glucose results in increased expression of CYBA mRNA	22245600
D005947	Glucose	Glucose results in increased expression of CYBA protein	22245600
D005947	Glucose	[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species	22245600
D005947	Glucose	[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein	22245600
D005947	Glucose	pyrazolanthrone inhibits the reaction [Glucose results in increased expression of CYBA protein]	22245600
D005947	Glucose	resveratrol inhibits the reaction [Glucose results in increased expression of CYBA mRNA]	22245600
D005947	Glucose	resveratrol inhibits the reaction [Glucose results in increased expression of CYBA protein]	22245600
D005947	Glucose	resveratrol inhibits the reaction [[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein]	22245600
D005947	Glucose	NFKBIA gene mutant form inhibits the reaction [Glucose results in increased expression of CYBA protein]	22245600
C449302	GW 6471	GW 6471 inhibits the reaction [resveratrol inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]]	23422569
D006852	Hydrochlorothiazide	Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA]	21107329
D006861	Hydrogen Peroxide	Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	25305479
D006861	Hydrogen Peroxide	Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	25305479
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYBA mRNA	25305479
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYBA protein	25305479
D006861	Hydrogen Peroxide	Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	25305479
D006861	Hydrogen Peroxide	Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	25305479
D006861	Hydrogen Peroxide	Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	25305479
D006861	Hydrogen Peroxide	Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	25305479
D006861	Hydrogen Peroxide	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	23270704
D006861	Hydrogen Peroxide	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	23270704
D006861	Hydrogen Peroxide	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	23270704
D006861	Hydrogen Peroxide	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	23270704
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYBA mRNA	23270704
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYBA protein	23270704
D003900	Desoxycorticosterone	[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of CYBA protein	22431579
D003900	Desoxycorticosterone	Desoxycorticosterone results in increased expression of CYBA mRNA	16271043
D003900	Desoxycorticosterone	Desoxycorticosterone results in increased expression of CYBA protein	16271043
C492448	ICG 001	ICG 001 results in decreased expression of CYBA mRNA	26191083
D007505	Iron-Dextran Complex	Iron-Dextran Complex results in increased expression of CYBA protein	15086920
D007545	Isoproterenol	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]	18594475
D007545	Isoproterenol	Isoproterenol results in increased expression of CYBA mRNA	18594475
D007545	Isoproterenol	pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]	18594475
C468270	Kangen-karyu	Kangen-karyu results in decreased expression of CYBA protein	21372389\|2296982
D007649	Ketamine	Ketamine results in increased expression of CYBA	18063801
C482199	lipopolysaccharide, E coli O55-B5	"[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CYBA protein"	28887131
C482199	lipopolysaccharide, E coli O55-B5	"ONO 1301 inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CYBA protein]"	28887131
D008070	Lipopolysaccharides	CYBA protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]	18414230
D008070	Lipopolysaccharides	CYBA protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]	18414230
D008070	Lipopolysaccharides	CYBA protein affects the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]	18414230
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CYBA mRNA	27339419
C059516	loganin	loganin affects the expression of CYBA protein	21864639
D019808	Losartan	Losartan inhibits the reaction [AGT protein modified form results in increased expression of CYBA mRNA]	22306536
D014975	Lutein	[Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA	24865317
D014975	Lutein	Lutein results in decreased expression of CYBA mRNA	24865317
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of CYBA protein]	18088078
C054218	manidipine	manidipine results in decreased expression of CYBA mRNA	15085064
C054218	manidipine	[sodium arsenite co-treated with manidipine] results in decreased expression of CYBA mRNA	15085064
C054218	manidipine	[sodium arsenite co-treated with manidipine] results in decreased expression of CYBA protein	15085064
C545385	Mequindox	Mequindox affects the expression of CYBA mRNA	21146578
C545385	Mequindox	Mequindox results in increased expression of CYBA mRNA	20553828
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CYBA mRNA	28987480
D008627	Mercuric Chloride	Peptides inhibits the reaction [Mercuric Chloride results in increased expression of CYBA mRNA]	28987480
D008687	Metformin	Metformin results in decreased expression of CYBA mRNA	15531508
D008687	Metformin	Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]	27634381
D008687	Metformin	Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]	27634381
D000432	Methanol	diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA mRNA]	25726414
D000432	Methanol	diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA protein]	25726414
D000432	Methanol	Methanol results in increased expression of CYBA protein	25726414
D000432	Methanol	phenyl-N-tert-butylnitrone inhibits the reaction [Methanol results in increased expression of CYBA mRNA]	25726414
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYBA mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CYBA mRNA	23458150
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CYBA mRNA	23649840
D008777	Methyltestosterone	Methyltestosterone results in increased expression of CYBA mRNA	29191790
C523799	MRK 003	CYBA results in increased susceptibility to MRK 003	19903844
C568376	MT19c compound	MT19c compound results in decreased expression of CYBA mRNA	21781307
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of CYBA mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CYBA mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CYBA mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of CYBA mRNA	25380136
C005274	naringin	naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]	25391245
C005274	naringin	naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]	25391245
D000068577	Nebivolol	Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]	16940222
D009525	Niacin	Niacin results in decreased expression of CYBA protein	19420110
D009532	Nickel	Nickel results in increased expression of CYBA mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in increased expression of CYBA mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of CYBA mRNA	22714537
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of CYBA mRNA	19716841
C025256	nonylphenol	nonylphenol results in decreased expression of CYBA mRNA	22982499
C025589	ochratoxin A	ochratoxin A results in increased acetylation of CYBA promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of CYBA promoter] which results in increased expression of CYBA mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of CYBA mRNA	17316727\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of CYBA mRNA	23358140
C437965	olmesartan	olmesartan results in decreased expression of CYBA protein	17170375
C105488	ONO 1301	"ONO 1301 inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CYBA protein]"	28887131
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of CYBA mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of CYBA mRNA"	24096037
D019815	Oxalic Acid	Oxalic Acid results in increased expression of CYBA mRNA	24145091
D019815	Oxalic Acid	resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CYBA mRNA]	24145091
D010098	Oxycodone	Oxycodone results in decreased expression of CYBA mRNA	23439660
D019308	Palmitic Acid	CYBA mutant form inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA]	24080574
D019308	Palmitic Acid	CYBA mutant form inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA]	24080574
D019308	Palmitic Acid	CYBA mutant form inhibits the reaction [Palmitic Acid results in increased expression of RUNX2 mRNA]	24080574
D019308	Palmitic Acid	CYBA mutant form inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]	24080574
D019308	Palmitic Acid	CYBA mutant form inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]	24080574
D000073878	Palm Oil	Palm Oil results in decreased expression of CYBA mRNA	18042831
C084656	paricalcitol	[paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein	20720404
C084656	paricalcitol	paricalcitol results in decreased expression of CYBA protein	20720404
D052638	Particulate Matter	Particulate Matter results in increased expression of CYBA mRNA	21708214
D052638	Particulate Matter	Particulate Matter results in increased expression of CYBA mRNA	18599801
D010455	Peptides	Peptides inhibits the reaction [Mercuric Chloride results in increased expression of CYBA mRNA]	28987480
D010622	Phencyclidine	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
D010622	Phencyclidine	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
D010622	Phencyclidine	ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein]	29037473
D010622	Phencyclidine	GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]	29037473
D010622	Phencyclidine	Phencyclidine results in increased activity of CYBA protein	29037473
D019800	Phenol	Phenol results in increased expression of CYBA mRNA	16785328
C029217	phenyl-N-tert-butylnitrone	phenyl-N-tert-butylnitrone inhibits the reaction [Methanol results in increased expression of CYBA mRNA]	25726414
C004479	pimagedine	pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]	18594475
C060836	pioglitazone	pioglitazone results in decreased expression of CYBA mRNA	11172467
C060836	pioglitazone	pioglitazone affects the activity of CYBA protein	21962020
C006253	pirinixic acid	pirinixic acid results in decreased expression of CYBA mRNA	11798191\|1742611
D010936	Plant Extracts	Plant Extracts inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]	23994555
D010936	Plant Extracts	Plant Extracts inhibits the reaction [AGT protein results in increased expression of CYBA protein]	23994555
D010936	Plant Extracts	Plant Extracts inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of CYBA mRNA]]	23994555
D010936	Plant Extracts	Plant Extracts inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of CYBA protein]]	23994555
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	25305479
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	25305479
D010936	Plant Extracts	Plant Extracts affects the reaction [AGT protein results in increased expression of CYBA mRNA]	18047924
D028321	Plant Preparations	Plant Preparations results in decreased expression of CYBA mRNA	19450372
D028321	Plant Preparations	Plant Preparations results in decreased expression of CYBA protein	19450372
D059808	Polyphenols	Polyphenols results in decreased expression of CYBA mRNA	19450372
D059808	Polyphenols	Polyphenols results in decreased expression of CYBA protein	19450372
D011134	Polysaccharides	Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]	25305479
D011134	Polysaccharides	Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]	25305479
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of CYBA mRNA	22714537
D017035	Pravastatin	Pravastatin results in decreased expression of CYBA protein	17170375
D011339	Probenecid	Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of CYBA mRNA]	23325087
D011374	Progesterone	Progesterone results in increased degradation of CYBA protein	21551343
D011374	Progesterone	Progesterone results in increased expression of CYBA mRNA	16195479
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Glucose results in increased expression of CYBA protein]	22245600
D011794	Quercetin	Quercetin results in increased expression of CYBA mRNA	21632981
D011794	Quercetin	Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]	27634381
D011794	Quercetin	Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]	27634381
D017257	Ramipril	Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]	12352326
D017257	Ramipril	Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA]	12352326
D017257	Ramipril	Ramipril results in decreased expression of CYBA mRNA	16891913
D017382	Reactive Oxygen Species	CYBA protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]	22245600
D017382	Reactive Oxygen Species	[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species	22245600
D017382	Reactive Oxygen Species	[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein	22245600
D017382	Reactive Oxygen Species	resveratrol inhibits the reaction [[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein]	22245600
D017382	Reactive Oxygen Species	[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species	21562509
C059514	resveratrol	resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CYBA mRNA]	24145091
C059514	resveratrol	resveratrol results in increased expression of CYBA mRNA	22610192
C059514	resveratrol	GW 6471 inhibits the reaction [resveratrol inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]]	23422569
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of CYBA mRNA	25905778
C059514	resveratrol	resveratrol inhibits the reaction [Glucose results in increased expression of CYBA mRNA]	22245600
C059514	resveratrol	resveratrol inhibits the reaction [Glucose results in increased expression of CYBA protein]	22245600
C059514	resveratrol	resveratrol inhibits the reaction [[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein]	22245600
C059514	resveratrol	resveratrol inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]	23422569
C059514	resveratrol	resveratrol results in decreased expression of CYBA mRNA	20081535
C059514	resveratrol	resveratrol results in increased expression of CYBA mRNA	25905778
C089730	rosiglitazone	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA protein]]"	17916771
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA protein]	17916771
D000068718	Rosuvastatin Calcium	Rosuvastatin Calcium results in decreased expression of CYBA	21562509
D000068718	Rosuvastatin Calcium	[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species	21562509
D012402	Rotenone	Rotenone affects the expression of CYBA mRNA	23186747
C093642	SB 203580	SB 203580 inhibits the reaction [Ethanol results in increased expression of CYBA mRNA]	23978445
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CYBA mRNA	21602193
D019821	Simvastatin	CYBA gene SNP affects the susceptibility to Simvastatin	15936011
D020123	Sirolimus	Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]	21195169
C439060	sirtinol	sirtinol results in increased expression of CYBA mRNA	23422569
C017947	sodium arsenite	[sodium arsenite co-treated with Ethanol] results in increased expression of CYBA protein	22872060
C017947	sodium arsenite	[sodium arsenite co-treated with manidipine] results in decreased expression of CYBA mRNA	15085064
C017947	sodium arsenite	[sodium arsenite co-treated with manidipine] results in decreased expression of CYBA protein	15085064
C017947	sodium arsenite	sodium arsenite promotes the reaction [Ethanol results in increased expression of CYBA protein]	22872060
C017947	sodium arsenite	sodium arsenite results in increased expression of CYBA protein	19414066
C017947	sodium arsenite	Atorvastatin Calcium inhibits the reaction [sodium arsenite results in increased expression of CYBA mRNA]	25218292
C017947	sodium arsenite	sodium arsenite results in increased expression of CYBA mRNA	25218292\|2607920
D012965	Sodium Chloride	CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA]	27678262
D012965	Sodium Chloride	[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA	27678262
D012965	Sodium Chloride	[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of CYBA protein	22431579
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CYBA mRNA	27750169
D012999	Soman	Soman results in increased expression of CYBA mRNA	19281266
D013311	Streptozocin	Bezafibrate inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]	12967931
D013311	Streptozocin	candesartan inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]	16139267
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of CYBA mRNA	25905778
D013311	Streptozocin	Streptozocin results in increased expression of CYBA mRNA	12967931\|1613926
D013481	Superoxides	CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]	10720412
D013481	Superoxides	CYBA protein results in increased abundance of Superoxides	20523355
D013481	Superoxides	CYBA protein results in increased abundance of Superoxides	14871555
D016559	Tacrolimus	Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA]	12352326
D016559	Tacrolimus	Tacrolimus results in increased expression of CYBA mRNA	12352326
C061133	tamibarotene	tamibarotene results in increased expression of CYBA mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of CYBA mRNA	17555576
C084178	telmisartan	telmisartan results in decreased expression of CYBA mRNA	16141465
C084178	telmisartan	telmisartan results in decreased expression of CYBA protein	16141465
C084178	telmisartan	telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein]	21054405
C084178	telmisartan	telmisartan results in decreased expression of CYBA mRNA	19171132
C001803	tempol	tempol results in decreased expression of CYBA mRNA	16685210
C004648	testosterone enanthate	testosterone enanthate affects the expression of CYBA mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYBA mRNA	16051281\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYBA mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYBA mRNA	23864506\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYBA mRNA	20959002
D013755	Tetradecanoylphorbol Acetate	Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA]	11172467
D013755	Tetradecanoylphorbol Acetate	CYBA protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein]	21705328
D013755	Tetradecanoylphorbol Acetate	CYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]	20523355
D013755	Tetradecanoylphorbol Acetate	CYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]	20523355
D013755	Tetradecanoylphorbol Acetate	CYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	CYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT5A protein]	20523355
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA	11172467
D013755	Tetradecanoylphorbol Acetate	troglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA]	11172467
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CYBA mRNA	28943392
C009495	titanium dioxide	titanium dioxide results in increased expression of CYBA mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CYBA mRNA	20133372
C052035	trandolapril	[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA	17324946
C052035	trandolapril	trandolapril results in decreased expression of CYBA mRNA	17324946
D014212	Tretinoin	Tretinoin results in increased expression of CYBA mRNA	15498508\|1605412
C030665	triphenyltin	triphenyltin results in increased expression of CYBA protein	12788061
C057693	troglitazone	troglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA]	11172467
C057693	troglitazone	troglitazone results in decreased expression of CYBA mRNA	11172467
D014527	Uric Acid	CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]	18403674
D014635	Valproic Acid	Valproic Acid results in increased expression of CYBA mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased methylation of CYBA gene	29154799
D014638	Vanadates	Vanadates results in decreased expression of CYBA mRNA	22714537
C025643	vinclozolin	vinclozolin results in increased expression of CYBA mRNA	23034163
D009536	Niacinamide	Clofibrate inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]	23422569
D009536	Niacinamide	GW 6471 inhibits the reaction [resveratrol inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]]	23422569
D009536	Niacinamide	Niacinamide results in increased expression of CYBA mRNA	23422569
D009536	Niacinamide	resveratrol inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]	23422569
D014810	Vitamin E	Vitamin E results in decreased expression of CYBA mRNA	15571180
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of CYBA protein	16507596
D015054	Zymosan	Zymosan affects the localization of CYBA protein	19005069

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	3305576 11733522 16326715 16460309 17126813 17803994 23957209
GO:0009055	electron transfer activity	-	IDA	12042318
GO:0009055	electron transfer activity	-	TAS	2243141
GO:0016175	superoxide-generating NADPH oxidase activity	-	IBA	21873635
GO:0016175	superoxide-generating NADPH oxidase activity	contributes_to	IMP	1763037
GO:0016175	superoxide-generating NADPH oxidase activity	-	TAS	-
GO:0017124	SH3 domain binding	-	IPI	7938008
GO:0020037	heme binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IPI	12042318

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0001938	positive regulation of endothelial cell proliferation	-	IEA	-
GO:0003106	negative regulation of glomerular filtration by angiotensin	-	IEA	-
GO:0006801	superoxide metabolic process	-	IMP	1763037 2243141
GO:0006954	inflammatory response	-	IMP	2243141
GO:0014823	response to activity	-	IEA	-
GO:0014895	smooth muscle hypertrophy	-	ISS	-
GO:0017004	cytochrome complex assembly	-	IDA	7938008
GO:0022900	electron transport chain	-	IEA	-
GO:0030307	positive regulation of cell growth	-	IEA	-
GO:0032755	positive regulation of interleukin-6 production	-	IDA	22423966
GO:0032760	positive regulation of tumor necrosis factor production	-	IDA	22423966
GO:0032930	positive regulation of superoxide anion generation	-	IEA	-
GO:0033864	positive regulation of NAD(P)H oxidase activity	-	IEA	-
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	-	IDA	22423966
GO:0034599	cellular response to oxidative stress	-	TAS	-
GO:0042554	superoxide anion generation	-	IBA	21873635
GO:0042554	superoxide anion generation	-	IMP	2243141
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045087	innate immune response	-	IMP	2243141
GO:0045730	respiratory burst	-	IMP	2243141
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0050665	hydrogen peroxide biosynthetic process	-	ISS	-
GO:0050766	positive regulation of phagocytosis	-	IDA	22423966
GO:0051279	regulation of release of sequestered calcium ion into cytosol	-	IEA	-
GO:0055114	oxidation-reduction process	-	IMP	1763037 2243141
GO:0070257	positive regulation of mucus secretion	-	IEA	-
GO:0070555	response to interleukin-1	-	IEA	-
GO:0071260	cellular response to mechanical stimulus	-	IEA	-
GO:0071333	cellular response to glucose stimulus	-	IEA	-
GO:0071356	cellular response to tumor necrosis factor	-	IEA	-
GO:0071407	cellular response to organic cyclic compound	-	IEA	-
GO:0071480	cellular response to gamma radiation	-	IEA	-
GO:1900426	positive regulation of defense response to bacterium	-	IDA	22423966
GO:1903428	positive regulation of reactive oxygen species biosynthetic process	-	IDA	22423966
GO:1904044	response to aldosterone	-	IEA	-
GO:1904385	cellular response to angiotensin	-	IEA	-
GO:1904845	cellular response to L-glutamine	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001725	stress fiber	-	IEA	-
GO:0005634	nucleus	-	IEA	-
GO:0005768	endosome	-	IEA	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005925	focal adhesion	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016324	apical plasma membrane	-	IEA	-
GO:0030141	secretory granule	-	TAS	12005167
GO:0030425	dendrite	-	IEA	-
GO:0030670	phagocytic vesicle membrane	-	TAS	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0043020	NADPH oxidase complex	-	IBA	21873635
GO:0043020	NADPH oxidase complex	-	IDA	3305576
GO:0043020	NADPH oxidase complex	colocalizes_with	IDA	22423966
GO:0043020	NADPH oxidase complex	-	IMP	1763037
GO:0043025	neuronal cell body	-	IEA	-
GO:0070821	tertiary granule membrane	-	TAS	-
GO:0097038	perinuclear endoplasmic reticulum	-	IEA	-

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04380	Osteoclast differentiation
hsa04670	Leukocyte transendothelial migration
hsa05140	Leishmaniasis

Reactome ID	Reactome Term	Evidence
R-HSA-1222556	ROS, RNS production in phagocytes	TAS
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	TAS
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3299685	Detoxification of Reactive Oxygen Species	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22396743	Smoking dose modifies the association between C242T polymorphism and prevalence of metabolic syndrome in a Chinese population. (2012)	Ge J	PLoS One
24033955	Association of CYBA rs7195830 polymorphism with estimated glomerular filtration rate in an adult Han sample from Jiangsu province, China. (2013)	Fan KL	Chin Med J (Engl)
17627182	The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia. (2007 Aug)	Niemiec P	Coron Artery Dis
17563559	CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study. (2007 Jul)	Fan M	J Hypertens
19151692	The association between cigarette smoking and carotid intima-media thickness is influenced by the -930A/G CYBA gene polymorphism: the Cardiovascular Risk in Young Finns Study. (2009 Mar)	Fan M	Am J Hypertens
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