Gene info: ID 153572

Gene: IRX2

GENE ID: 153572

Synonyms: IRXA2

Description: iroquois homeobox 2

Gene type: protein-coding

Location: 5p15.33

dbXrefs: Ensembl:ENSG00000170561 MIM:606198 Vega:OTTHUMG00000090377 UniprotKB:Q9BZI1

RefSeq: NC_000005.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.000e-2 (AD) 2.837e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C5orf38	0.938
CRNDE	0.915
FEZF1	0.914
IRX1	0.894
FAM183A	0.884
OTP	0.877
LHX5	0.875
FOXB1	0.873
HCRT	0.872
SIM1	0.87

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TNNT2	-0.497
SLC17A7	-0.491
NEUROD2	-0.456
SOHLH1	-0.456
TESPA1	-0.452
EMX1	-0.445
CABP1	-0.434
MGAT5B	-0.422
TBR1	-0.42
KCNS1	-0.416

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of IRX2 mRNA"	26377693
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of IRX2 mRNA	16788091
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of IRX2 mRNA	26690555
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of IRX2 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of IRX2 mRNA	21298039
C487081	belinostat	belinostat results in increased expression of IRX2 mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IRX2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IRX2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IRX2 mRNA	21839799
D004958	Estradiol	Estradiol results in increased expression of IRX2 mRNA	18556351
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of IRX2 mRNA	18556351
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of IRX2 mRNA	25912373
C006780	bisphenol A	bisphenol A affects the methylation of IRX2 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of IRX2 mRNA	26063408
C006780	bisphenol A	bisphenol A results in decreased expression of IRX2 mRNA	25181051
D002104	Cadmium	Cadmium results in increased expression of IRX2 mRNA	24376830
D002220	Carbamazepine	Carbamazepine affects the expression of IRX2 mRNA	25979313
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IRX2 gene	20938992
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IRX2 mRNA	24386269
D002945	Cisplatin	Cisplatin results in increased expression of IRX2 mRNA	19561079
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of IRX2 mRNA	21658437
C118739	entinostat	entinostat results in decreased expression of IRX2 mRNA	27188386
C118739	entinostat	entinostat results in increased expression of IRX2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IRX2 gene	20938992
D007854	Lead	Lead affects the expression of IRX2 mRNA	28903495
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IRX2 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of IRX2 mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of IRX2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of IRX2 mRNA"	25554681
C007350	nitrofen	nitrofen results in increased expression of IRX2 mRNA	21238641
C007350	nitrofen	nitrofen results in increased expression of IRX2 protein	21238641
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of IRX2 mRNA	26272509
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of IRX2 mRNA	18556351
D011441	Propylthiouracil	Propylthiouracil results in increased expression of IRX2 mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of IRX2 mRNA	23806026
C075117	squalestatin 1	squalestatin 1 results in decreased expression of IRX2 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in increased expression of IRX2 mRNA	27225895
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IRX2 mRNA	24058054
C009495	titanium dioxide	titanium dioxide affects the expression of IRX2 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of IRX2 mRNA	23409001
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of IRX2 mRNA	28065790
D014212	Tretinoin	Tretinoin results in decreased expression of IRX2 mRNA	16788091
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of IRX2 mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of IRX2 mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of IRX2 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased expression of IRX2 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in increased methylation of IRX2 gene	29154799
D014638	Vanadates	Vanadates results in increased expression of IRX2 mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of IRX2 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of IRX2 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of IRX2 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of IRX2 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IC	-
GO:0043565	sequence-specific DNA binding	-	IDA	23332764

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	26560478
GO:0072086	specification of loop of Henle identity	-	IEA	-
GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24921089	Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. (2014 Jul 15)	Sato T	Int J Cancer