Gene info: ID 1536

Gene: CYBB

GENE ID: 1536

Synonyms: AMCBX2|CGD|GP91-1|GP91-PHOX|GP91PHOX|IMD34|NOX2|p91-PHOX

Description: cytochrome b-245 beta chain

Gene type: protein-coding

Location: Xp21.1-p11.4

dbXrefs: Ensembl:ENSG00000165168 MIM:300481 Vega:OTTHUMG00000033175 UniprotKB:P04839

RefSeq: NG_009065.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NCKAP1L	0.934
APBB1IP	0.933
SYK	0.933
BIN2	0.917
CD33	0.916
ITGB2	0.913
IRF8	0.912
ITGAM	0.91
SASH3	0.908
LPAR5	0.907

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HAGHL	-0.404
ASPDH	-0.397
ATP2C2	-0.389
HES6	-0.386
MAGIX	-0.379
HES5	-0.369
KREMEN2	-0.365
KCNIP3	-0.364
TM7SF2	-0.362
C9orf24	-0.353

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00514	Dextromethorphan	Small Molecule	125-71-3	Approved	Target

ID	Drug Name	Action	PubMed
C549500	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]	27678262
C118559	1-bromopropane	1-bromopropane results in increased expression of CYBB mRNA	27452781
C118559	1-bromopropane	1-bromopropane results in increased expression of CYBB protein	27452781
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYBB mRNA"	27291303
C417207	2,2',4,6,6'-pentachlorobiphenyl	"2,2',4,6,6'-pentachlorobiphenyl promotes the reaction [NCF1 protein binds to CYBB protein]"	20299304
C417207	2,2',4,6,6'-pentachlorobiphenyl	"2,2',4,6,6'-pentachlorobiphenyl promotes the reaction [NCF1 protein modified form binds to CYBB protein]"	20299304
C070055	2,3',4,4',5-pentachlorobiphenyl	"2,3',4,4',5-pentachlorobiphenyl promotes the reaction [NCF1 protein binds to CYBB protein]"	20299304
C070055	2,3',4,4',5-pentachlorobiphenyl	"2,3',4,4',5-pentachlorobiphenyl promotes the reaction [NCF1 protein modified form binds to CYBB protein]"	20299304
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [NCF1 protein binds to CYBB protein]"	20299304
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [NCF1 protein modified form binds to CYBB protein]"	20299304
C018855	2-tert-butylhydroquinone	"2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein]"	28844481
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [NCF1 protein binds to CYBB protein]"	20299304
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [NCF1 protein modified form binds to CYBB protein]"	20299304
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of CYBB mRNA]	23978445
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CYBB mRNA"	25380136
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]	23270704
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]	23270704
C027576	4-hydroxy-2-nonenal	CYBB protein results in increased abundance of 4-hydroxy-2-nonenal	19417757
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CYBB protein]]"	26054749
C003001	7-ketocholesterol	7-ketocholesterol affects the localization of CYBB protein	28633109
C003001	7-ketocholesterol	Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]	28633109
C003001	7-ketocholesterol	Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein]	28633109
D000079	Acetaldehyde	Acetaldehyde results in increased expression of CYBB mRNA	18845238
D000082	Acetaminophen	Acetaminophen results in increased expression of CYBB mRNA	19739265
D000082	Acetaminophen	Acetaminophen results in increased expression of CYBB protein	27866976
D000082	Acetaminophen	manumycin inhibits the reaction [Acetaminophen results in increased expression of CYBB mRNA]	19739265
D000082	Acetaminophen	Methionine inhibits the reaction [Acetaminophen results in increased expression of CYBB mRNA]	19739265
D000082	Acetaminophen	rosiglitazone inhibits the reaction [Acetaminophen results in increased expression of CYBB protein]	27866976
C056165	acetovanillone	acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein]	19878672
C056165	acetovanillone	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]	23270704
C056165	acetovanillone	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]	23270704
C056165	acetovanillone	acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]	24080574
D000109	Acetylcholine	CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]	18522491
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]	21195169
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CYBB gene	27153756
C031143	AICA ribonucleotide	AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]	21195169
D006710	Homocysteine	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]	21647593
D006710	Homocysteine	CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]	21647593
D006710	Homocysteine	CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]	20116427
D006710	Homocysteine	CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]	20116427
D006710	Homocysteine	CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]	20116427
D006710	Homocysteine	CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]	20116427
D006710	Homocysteine	CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]	20116427
D006710	Homocysteine	Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein]	20036696
D006710	Homocysteine	Homocysteine affects the localization of CYBB protein	20036696
D006710	Homocysteine	Homocysteine results in increased expression of CYBB mRNA	20116427
D006710	Homocysteine	Homocysteine results in increased expression of CYBB protein	20116427
D006710	Homocysteine	methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of CYBB protein]	20036696
D000639	Amitriptyline	Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]	28633109
D000639	Amitriptyline	Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein]	28633109
D000640	Amitrole	"Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein]"	25891026
D017311	Amlodipine	Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB]	21107329
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CYBB mRNA	16483693
C530884	anacetrapib	anacetrapib results in increased expression of CYBB protein	25617244
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CYBB mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of CYBB mRNA	19654921
D001151	Arsenic	Arsenic results in increased expression of CYBB protein	24348802
D001151	Arsenic	Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of CYBB protein]	24348802
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CYBB mRNA	20458559
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CYBB mRNA	15894607
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CYBB mRNA	28454374
D001241	Aspirin	Aspirin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]	22306536
D001280	Atrazine	Atrazine results in increased expression of CYBB mRNA	26256823
D001280	Atrazine	Atrazine results in increased expression of CYBB protein	26256823
C547126	AZM551248	AZM551248 results in increased expression of CYBB mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CYBB mRNA	21569818
D004958	Estradiol	Estradiol inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]	16097371
D004958	Estradiol	Estradiol inhibits the reaction [AGT protein results in increased expression of CYBB protein]	16097371
D004958	Estradiol	[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CYBB protein	21670166
D001629	Bezafibrate	Bezafibrate results in increased expression of CYBB protein	20594415
C006780	bisphenol A	[bisphenol A co-treated with Dietary Fats] results in increased expression of CYBB mRNA	25112833
C006780	bisphenol A	bisphenol A results in decreased expression of CYBB mRNA	25181051\|2574866
D002065	Buspirone	Buspirone results in decreased expression of CYBB mRNA	24136188
D002104	Cadmium	Cadmium results in increased expression of CYBB mRNA	21787725
D002104	Cadmium	Cadmium results in increased expression of CYBB protein	23916567
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CYBB protein	21195169
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]	21195169
D019256	Cadmium Chloride	AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]	21195169
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CYBB mRNA	25993096
D019256	Cadmium Chloride	PTEN inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]	21195169
D019256	Cadmium Chloride	Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]	21195169
D002118	Calcium	CYBB protein affects the reaction [AGT protein modified form affects the transport of Calcium]	16894058
C081643	candesartan	Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB]	21107329
C081643	candesartan	candesartan results in decreased expression of CYBB	21107329
C081643	candesartan	candesartan results in decreased expression of CYBB mRNA	16685210
C081643	candesartan	Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB]	21107329
D002211	Capsaicin	CYBB protein affects the reaction [TRPV1 protein results in increased susceptibility to Capsaicin]	18203709
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYBB mRNA	27339419
D002251	Carbon Tetrachloride	CYBB gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]	17105591
D002251	Carbon Tetrachloride	CYBB gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]	17105591
D002251	Carbon Tetrachloride	CYBB gene mutant form results in decreased susceptibility to Carbon Tetrachloride	17105591
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CYBB protein	17854599
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYBB mRNA	17854599
C093373	cariporide	"cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]"	24070585
C093373	cariporide	"cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]"	24070585
C093373	cariporide	"[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]"	24070585
C093373	cariporide	"[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]"	24070585
C070295	catalase-polyethylene glycol	"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein]"	25891026
D002392	Catechin	[Catechin co-treated with Dietary Fats] affects the expression of CYBB mRNA	25861419
D002737	Chloroprene	Chloroprene results in decreased expression of CYBB mRNA	23125180
D002784	Cholesterol	Cholesterol analog affects the localization of CYBB protein	28633109
C000593591	coagulin-L	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]	27568862
D003035	Cobalt	Cobalt results in decreased expression of CYBB mRNA	17967803
D003042	Cocaine	Cocaine results in increased expression of CYBB protein	18952886
D003042	Cocaine	CYBB results in increased susceptibility to Cocaine	18952886
D009249	NADP	CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]	17275678
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of CYBB mRNA	17654400
C411602	dalcetrapib	dalcetrapib results in increased expression of CYBB protein	25617244
D003630	Daunorubicin	Daunorubicin results in increased expression of CYBB mRNA	23831762
D003630	Daunorubicin	Dexrazoxane inhibits the reaction [Daunorubicin results in increased expression of CYBB mRNA]	23831762
D003630	Daunorubicin	Daunorubicin results in increased expression of CYBB mRNA	27090888
D064791	Desoxycorticosterone Acetate	CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA]	27678262
D064791	Desoxycorticosterone Acetate	"CYBB protein affects the susceptibility to [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary]"	21368743
D064791	Desoxycorticosterone Acetate	[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA	27678262
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBB mRNA]	9794432
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]	27568862
D064730	Dexrazoxane	Dexrazoxane inhibits the reaction [Daunorubicin results in increased expression of CYBB mRNA]	23831762
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of CYBB mRNA	23894361
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of CYBB protein	20637373
D002945	Cisplatin	Cisplatin results in increased expression of CYBB mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of CYBB mRNA	23603837\|2518474
D002945	Cisplatin	Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA]	23603837
D002945	Cisplatin	fisetin inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA]	25184746
D002945	Cisplatin	Cisplatin results in increased expression of CYBB	21884784
D004006	Dichlorvos	Dichlorvos results in increased expression of CYBB mRNA	21964614
D004006	Dichlorvos	Dichlorvos results in increased expression of CYBB protein	21964614
D004008	Diclofenac	Diclofenac results in increased expression of CYBB mRNA	26934552
D004041	Dietary Fats	[Catechin co-treated with Dietary Fats] affects the expression of CYBB mRNA	25861419
D004041	Dietary Fats	Dietary Fats results in decreased expression of CYBB mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of CYBB mRNA	25016146
D004041	Dietary Fats	[Plant Preparations co-treated with Dietary Fats] affects the expression of CYBB mRNA	25861419
D004041	Dietary Fats	[bisphenol A co-treated with Dietary Fats] results in increased expression of CYBB mRNA	25112833
D004041	Dietary Fats	[Dietary Fats co-treated with Fructose] results in increased expression of CYBB mRNA	19632207
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CYBB mRNA	25380136
C056189	di-n-butyltin	di-n-butyltin results in increased expression of CYBB mRNA	24631921
D004317	Doxorubicin	CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]	17275678
C060311	eckol	eckol results in decreased expression of CYBB protein	21514314
D015777	Eicosanoids	Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA]	23603837
D004726	Endosulfan	Endosulfan results in increased expression of CYBB mRNA	25199686
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of CYBB mRNA	27659729
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of CYBB protein	27659729
D000431	Ethanol	Ethanol results in increased expression of CYBB mRNA	18845238
D000431	Ethanol	Ethanol results in increased expression of CYBB protein	26079697
D000431	Ethanol	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of CYBB mRNA]	23978445
D000431	Ethanol	CYBB mutant form inhibits the reaction [Ethanol results in increased abundance of Reactive Oxygen Species]	23978445
D000431	Ethanol	CYBB mutant form inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]	23978445
D000431	Ethanol	CYBB mutant form inhibits the reaction [Ethanol results in increased expression of MMP12 protein]	23978445
D000431	Ethanol	Ethanol results in increased expression of CYBB mRNA	23978445
D000431	Ethanol	Ethanol results in increased expression of CYBB protein	23978445
D000431	Ethanol	NFKBIA protein affects the reaction [Ethanol results in increased expression of CYBB mRNA]	23978445
D000431	Ethanol	SB 203580 inhibits the reaction [Ethanol results in increased expression of CYBB mRNA]	23978445
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CYBB mRNA	17351261
D005372	Filipin	Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein]	20036696
C017875	fisetin	fisetin inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA]	25184746
D005419	Flavonoids	Flavonoids results in decreased expression of CYBB mRNA	18035473
D005485	Flutamide	Flutamide results in decreased expression of CYBB mRNA	24136188
D005492	Folic Acid	CYBB mutant form inhibits the reaction [Folic Acid deficiency results in decreased expression of CDH3 protein]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [Folic Acid deficiency results in decreased expression of NPHS2 protein]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [Folic Acid deficiency results in increased expression of ACTA2 protein]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [Folic Acid deficiency results in increased expression of S100A4 protein]	21647593
D005492	Folic Acid	CYBB mutant form inhibits the reaction [Folic Acid deficiency results in increased secretion of ALB protein]	21647593
D005492	Folic Acid	CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]	20116427
D005492	Folic Acid	CYBB protein affects the susceptibility to Folic Acid deficiency	20116427
D005492	Folic Acid	CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]	20116427
D005492	Folic Acid	CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]	20116427
D005492	Folic Acid	CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]	20116427
D005492	Folic Acid	CYBB results in increased susceptibility to Folic Acid	21647593
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of CYBB mRNA	20846436
D005632	Fructose	[Dietary Fats co-treated with Fructose] results in increased expression of CYBB mRNA	19632207
D019833	Genistein	Genistein results in decreased expression of CYBB mRNA	24967385
D005839	Gentamicins	Gentamicins results in increased expression of CYBB mRNA	22061828
D005947	Glucose	acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein]	19878672
D005947	Glucose	Glucose results in increased expression of and results in increased activity of CYBB protein	19878672
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein	21925195
D005947	Glucose	Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein]	21925195
D005947	Glucose	prolinedithiocarbamate inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein]	21925195
D005947	Glucose	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CYBB protein]]"	26054749
D005947	Glucose	Glucose results in increased expression of CYBB protein	26054749
D005947	Glucose	Glucose results in increased localization of CYBB protein	22253932
D005947	Glucose	resveratrol inhibits the reaction [Glucose results in increased expression of CYBB protein]	26054749
D056604	Grape Seed Extract	Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of CYBB protein]	24348802
C425931	GW 501516	GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein]	22886847
D006852	Hydrochlorothiazide	Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB]	21107329
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYBB protein	19401454
D006861	Hydrogen Peroxide	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]	23270704
D006861	Hydrogen Peroxide	4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]	23270704
D006861	Hydrogen Peroxide	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]	23270704
D006861	Hydrogen Peroxide	acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]	23270704
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYBB mRNA	23270704
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYBB protein	23270704
D007220	Industrial Waste	Industrial Waste results in decreased expression of CYBB mRNA	21396992
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CYBB mRNA	25613284
D007505	Iron-Dextran Complex	Iron-Dextran Complex results in increased expression of CYBB protein	28700905
D007649	Ketamine	Ketamine results in increased expression of CYBB	18063801
D048628	Ketolides	Ketolides analog results in increased expression of CYBB mRNA	24967691
D007854	Lead	Lead results in increased expression of CYBB protein	25596430
C008261	lead acetate	lead acetate results in increased expression of CYBB protein	15569323
C008261	lead acetate	lead acetate affects the expression of CYBB mRNA	21829687
C008261	lead acetate	lead acetate results in increased expression of CYBB mRNA	22641619
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of CYBB protein"	24211520
C433788	lipopolysaccharide, E. coli O26-B6	"schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CYBB protein]"	24211520
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CYBB mRNA"	24972896
C440499	lipopolysaccharide, Escherichia coli O111 B4	"cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]"	24070585
C440499	lipopolysaccharide, Escherichia coli O111 B4	"cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]"	24070585
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA"	24070585
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein"	24070585
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]"	24070585
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]"	24070585
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]"	24070585
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]"	24070585
D008070	Lipopolysaccharides	CYBB mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]	24967690
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CYBB protein	17855475
D008070	Lipopolysaccharides	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB protein]	17855475
D008070	Lipopolysaccharides	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]	27568862
D008070	Lipopolysaccharides	CYBB protein affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]	15795323
D008070	Lipopolysaccharides	CYBB protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]	15795323
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]	27568862
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of CYBB protein	19005069
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CYBB mRNA	15795323\|2733941
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CYBB protein	15795323\|1785547
D008070	Lipopolysaccharides	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB protein]	17855475
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CYBB mRNA	25613284
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CYBB protein	17448908
D019808	Losartan	Losartan inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]	22306536
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYBB mRNA	26378955
D008315	Malondialdehyde	CYBB protein results in increased abundance of Malondialdehyde	19417757
C054474	manumycin	manumycin inhibits the reaction [Acetaminophen results in increased expression of CYBB mRNA]	19739265
D017258	Medroxyprogesterone Acetate	[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CYBB protein	21670166
C545385	Mequindox	Mequindox results in increased expression of CYBB mRNA	20553828
D008694	Methamphetamine	CCK protein modified form inhibits the reaction [Methamphetamine promotes the reaction [NCF1 protein binds to CYBB protein]]	27565679
D008694	Methamphetamine	Methamphetamine promotes the reaction [NCF1 protein binds to CYBB protein]	27565679
D008715	Methionine	Methionine inhibits the reaction [Acetaminophen results in increased expression of CYBB mRNA]	19739265
C108732	methyl-beta-cyclodextrin	methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of CYBB protein]	20036696
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA	18643790
D015655	1-Methyl-4-phenylpyridinium	phenylmethylpyrazolone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]	18643790
D009020	Morphine	Morphine results in increased expression of CYBB protein	14871405
D009020	Morphine	Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]	14871405
C080418	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB protein]	17855475
C080418	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of CYBB protein]	17855475
C080418	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB protein]	17855475
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of CYBB mRNA	25380136
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of CYBB mRNA	19812364
D000068577	Nebivolol	Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]	16940222
C051752	nefazodone	nefazodone results in decreased expression of CYBB mRNA	24136188
D009532	Nickel	Nickel results in increased expression of CYBB mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of CYBB mRNA	19167457
C012655	nimesulide	nimesulide results in decreased expression of CYBB mRNA	24136188
C007350	nitrofen	nitrofen results in increased expression of CYBB mRNA	26534761
D005996	Nitroglycerin	CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]	18522491
D005996	Nitroglycerin	CYBB gene mutant form results in decreased susceptibility to Nitroglycerin	18522491
D005996	Nitroglycerin	Nitroglycerin results in increased expression of CYBB mRNA	16633368
D005996	Nitroglycerin	Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]	16633368
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of CYBB mRNA	17493633
C025589	ochratoxin A	ochratoxin A results in increased expression of CYBB mRNA	23358140
D015242	Ofloxacin	CYBB mutant form inhibits the reaction [Ofloxacin results in decreased expression of ITGB1 protein]	23274517
D015242	Ofloxacin	CYBB mutant form inhibits the reaction [Ofloxacin results in increased abundance of Reactive Oxygen Species]	23274517
D015242	Ofloxacin	CYBB protein affects the reaction [Ofloxacin results in increased phosphorylation of EGFR protein]	23274517
D016627	Oxidopamine	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of CYBB protein]	17855475
D016627	Oxidopamine	Oxidopamine results in increased expression of CYBB protein	17855475
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein	21925195
D010100	Oxygen	Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein]	21925195
D010100	Oxygen	prolinedithiocarbamate inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein]	21925195
D019308	Palmitic Acid	acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]	24080574
D019308	Palmitic Acid	Palmitic Acid results in increased expression of CYBB mRNA	24080574
D019308	Palmitic Acid	U 0126 inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]	24080574
D000073878	Palm Oil	Palm Oil results in decreased expression of CYBB mRNA	18042831
C010272	palytoxin	palytoxin results in increased expression of CYBB mRNA	23142474
D052638	Particulate Matter	CYBB gene mutant form inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]	19371610
D052638	Particulate Matter	CYBB gene mutant form inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]	19371610
D052638	Particulate Matter	CYBB gene mutant form results in decreased susceptibility to Particulate Matter	19371610
D052638	Particulate Matter	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of EGR1 mRNA]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of EGR1 mRNA]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of IL6 mRNA]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]	22178768
D052638	Particulate Matter	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]]	22178768
D052638	Particulate Matter	CYBB protein results in increased susceptibility to Particulate Matter	15319363
D052638	Particulate Matter	Particulate Matter results in increased expression of CYBB protein	18474546
D010634	Phenobarbital	Phenobarbital affects the expression of CYBB mRNA	23091169
D019800	Phenol	Phenol results in increased expression of CYBB mRNA	16785328
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]	18643790
C006253	pirinixic acid	pirinixic acid inhibits the reaction [PNPLA2 gene mutant form results in increased expression of CYBB mRNA]	25285770
D010936	Plant Extracts	Plant Extracts results in increased expression of CYBB mRNA	23557933
D028321	Plant Preparations	Plant Preparations results in decreased expression of CYBB mRNA	19450372
D028321	Plant Preparations	Plant Preparations results in decreased expression of CYBB protein	19450372
D028321	Plant Preparations	[Plant Preparations co-treated with Dietary Fats] affects the expression of CYBB mRNA	25861419
C058229	polydatin	polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]	25488910
C058229	polydatin	polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB protein]	25488910
D059808	Polyphenols	Polyphenols results in decreased expression of CYBB mRNA	19450372
D059808	Polyphenols	Polyphenols results in decreased expression of CYBB protein	19450372
D011353	Prodigiosin	Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein]	21925195
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein]	21925195
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CYBB mRNA	23921912\|2478091
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of CYBB mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of CYBB mRNA	19207477
D011794	Quercetin	Quercetin results in decreased expression of CYBB protein	19207477
D011794	Quercetin	Quercetin analog inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]	19794523
D017257	Ramipril	Ramipril results in decreased expression of CYBB mRNA	16891913
D017382	Reactive Oxygen Species	CYBB mutant form inhibits the reaction [Ethanol results in increased abundance of Reactive Oxygen Species]	23978445
D017382	Reactive Oxygen Species	CYBB mutant form inhibits the reaction [Ofloxacin results in increased abundance of Reactive Oxygen Species]	23274517
D017382	Reactive Oxygen Species	[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species	21562509
D017382	Reactive Oxygen Species	CYBB protein affects the abundance of Reactive Oxygen Species	16894058
D017382	Reactive Oxygen Species	CYBB protein affects the reaction [AGT protein modified form results in increased chemical synthesis of Reactive Oxygen Species]	16894058
D017382	Reactive Oxygen Species	CYBB protein results in increased abundance of Reactive Oxygen Species	21593737
C059514	resveratrol	resveratrol results in decreased expression of CYBB protein	19478208\|2514019
C059514	resveratrol	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CYBB protein]]"	26054749
C059514	resveratrol	resveratrol inhibits the reaction [Glucose results in increased expression of CYBB protein]	26054749
C059514	resveratrol	resveratrol inhibits the reaction [Rotenone results in increased expression of CYBB protein]	23593274
C059514	resveratrol	resveratrol results in decreased expression of CYBB mRNA	20081535
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Acetaminophen results in increased expression of CYBB protein]	27866976
D000068718	Rosuvastatin Calcium	Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]	16633368
D000068718	Rosuvastatin Calcium	Rosuvastatin Calcium results in decreased expression of CYBB	21562509
D000068718	Rosuvastatin Calcium	[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species	21562509
D012402	Rotenone	resveratrol inhibits the reaction [Rotenone results in increased expression of CYBB protein]	23593274
D012402	Rotenone	Rotenone results in increased expression of CYBB protein	23593274
C066201	salvianolic acid A	salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of CYBB protein]	19822164
C076944	salvianolic acid B	salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of CYBB protein]	19822164
C076944	salvianolic acid B	salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of CYBB protein]	19822164
D019258	Saquinavir	Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]	14871405
C093642	SB 203580	SB 203580 inhibits the reaction [Ethanol results in increased expression of CYBB mRNA]	23978445
C033585	schizandrol B	"schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CYBB protein]"	24211520
C440975	silybin	silybin inhibits the reaction [sodium arsenite results in increased expression of CYBB]	24062023
D019821	Simvastatin	Simvastatin results in decreased expression of CYBB mRNA	16157767
D020123	Sirolimus	Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]	21195169
C017947	sodium arsenite	sodium arsenite results in decreased expression of CYBB mRNA	27908234
C017947	sodium arsenite	silybin inhibits the reaction [sodium arsenite results in increased expression of CYBB]	24062023
C017947	sodium arsenite	sodium arsenite results in increased expression of CYBB	24062023
C017947	sodium arsenite	sodium arsenite results in increased expression of CYBB mRNA	26079204
D012965	Sodium Chloride	CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA]	27678262
D012965	Sodium Chloride	[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA	27678262
D017673	Sodium Chloride, Dietary	"CYBB protein affects the susceptibility to [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary]"	21368743
D017673	Sodium Chloride, Dietary	"2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein]"	28844481
D017673	Sodium Chloride, Dietary	"Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein]"	25891026
D017673	Sodium Chloride, Dietary	"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein]"	25891026
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in increased expression of CYBB mRNA"	26518973
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in increased expression of CYBB protein"	25891026\|2651897
D017673	Sodium Chloride, Dietary	"Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB]"	26518973
D053260	Soot	Soot results in increased expression of CYBB mRNA	22461453
D053260	Soot	Soot results in increased expression of CYBB mRNA	28283350
D053260	Soot	Soot results in increased expression of CYBB protein	28283350
D013148	Spironolactone	Spironolactone results in decreased expression of CYBB protein	19114643
D013311	Streptozocin	Streptozocin results in increased expression of CYBB protein	21381899
D013311	Streptozocin	telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]	21381899
D013311	Streptozocin	Streptozocin results in increased expression of CYBB protein	19957251
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYBB mRNA	26378955
C016766	sulforafan	sulforafan results in increased expression of CYBB mRNA	26833863
D013481	Superoxides	IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]	16354686
D013481	Superoxides	CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]	21647593
D013481	Superoxides	CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]	20116427
D013481	Superoxides	CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]	20116427
D013481	Superoxides	CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]	17275678
C061133	tamibarotene	tamibarotene results in increased expression of CYBB mRNA	15498508
C084178	telmisartan	telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]	21381899
C084178	telmisartan	telmisartan results in decreased expression of CYBB mRNA	19171132
C001803	tempol	tempol results in decreased expression of CYBB	20943769
C001803	tempol	tempol results in decreased expression of CYBB mRNA	16685210
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYBB mRNA	26377647\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYBB mRNA	28213091
D013755	Tetradecanoylphorbol Acetate	Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBB mRNA]	9794432
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CYBB mRNA	9794432
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CYBB mRNA	25613284
C050950	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased expression of CYBB protein	20164154
D013779	Tetrodotoxin	"[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]"	24070585
D013779	Tetrodotoxin	"[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]"	24070585
D013779	Tetrodotoxin	"Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]"	24070585
D013779	Tetrodotoxin	"Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]"	24070585
D013853	Thioacetamide	salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of CYBB protein]	19822164
D013853	Thioacetamide	salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of CYBB protein]	19822164
D013853	Thioacetamide	Thioacetamide results in increased expression of CYBB protein	19822164
D008063	Thioctic Acid	"Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB]"	26518973
C009495	titanium dioxide	titanium dioxide results in decreased expression of CYBB mRNA	27760801
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of EGR1 mRNA]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of EGR1 mRNA]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of IL6 mRNA]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution results in increased expression of EGR1]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]	22178768
D014028	Tobacco Smoke Pollution	CYBB protein affects the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]	22178768
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CYBB mRNA	20133372
C483909	torcetrapib	torcetrapib results in increased expression of CYBB protein	25617244
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CYBB mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of CYBB mRNA	15498508\|1589460
C011559	tributyltin	tributyltin results in increased expression of CYBB protein	26873547
C012589	trichostatin A	trichostatin A results in decreased expression of CYBB mRNA	15901671
C113580	U 0126	U 0126 inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]	24080574
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYBB mRNA	15901671
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]	15643130
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein]	15643130
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of CYBB mRNA	16330358
D001335	Vehicle Emissions	CYBB protein results in increased susceptibility to Vehicle Emissions	15319363
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CYBB gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CYBB protein	18474546
C025643	vinclozolin	vinclozolin affects the expression of CYBB mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of CYBB mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CYBB mRNA	26682919
D015032	Zinc	Zinc deficiency results in increased expression of CYBB	20128680
D015054	Zymosan	CYBB protein affects the susceptibility to Zymosan	14507659
D015054	Zymosan	Zymosan results in increased activity of CYBB protein	19005069

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005244	voltage-gated ion channel activity	-	IEA	-
GO:0005515	protein binding	-	IPI	3305576
GO:0009055	electron transfer activity	contributes_to	IDA	12042318
GO:0016175	superoxide-generating NADPH oxidase activity	contributes_to	IDA	12042318
GO:0016175	superoxide-generating NADPH oxidase activity	-	TAS	12716910
GO:0020037	heme binding	-	IMP	9774399
GO:0046872	metal ion binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IPI	12042318
GO:0050660	flavin adenine dinucleotide binding	-	IMP	9774399

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006801	superoxide metabolic process	-	IDA	12042318
GO:0006801	superoxide metabolic process	-	TAS	12716910
GO:0006954	inflammatory response	-	ISS	-
GO:0022900	electron transport chain	-	IEA	-
GO:0034220	ion transmembrane transport	-	IEA	-
GO:0034599	cellular response to oxidative stress	-	TAS	-
GO:0034765	regulation of ion transmembrane transport	-	IEA	-
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	-	IEA	-
GO:0042554	superoxide anion generation	-	IDA	12042318
GO:0042554	superoxide anion generation	-	TAS	12716910
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045087	innate immune response	-	IMP	9774399
GO:0045087	innate immune response	-	TAS	12716910
GO:0045730	respiratory burst	-	IMP	9774399
GO:0045730	respiratory burst	-	TAS	12716910
GO:0045766	positive regulation of angiogenesis	-	IEA	-
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0050665	hydrogen peroxide biosynthetic process	-	IEA	-
GO:0055114	oxidation-reduction process	-	IDA	12042318
GO:0055114	oxidation-reduction process	-	TAS	12716910
GO:0071276	cellular response to cadmium ion	-	IEA	-
GO:0071361	cellular response to ethanol	-	IEA	-
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	-	IEA	-
GO:1904044	response to aldosterone	-	IEA	-
GO:1904845	cellular response to L-glutamine	-	IEA	-
GO:1990776	response to angiotensin	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005635	nuclear envelope	-	IEA	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005791	rough endoplasmic reticulum	-	IEA	-
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	15233623
GO:0030425	dendrite	-	IEA	-
GO:0030670	phagocytic vesicle membrane	-	TAS	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0043020	NADPH oxidase complex	-	IDA	3305576
GO:0043020	NADPH oxidase complex	-	TAS	12716910
GO:0043025	neuronal cell body	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IEA	-
GO:0070821	tertiary granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04380	Osteoclast differentiation
hsa04670	Leukocyte transendothelial migration

Reactome ID	Reactome Term	Evidence
R-HSA-1222556	ROS, RNS production in phagocytes	TAS
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	TAS
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3299685	Detoxification of Reactive Oxygen Species	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25929165	Association of CYBB polymorphisms with tuberculosis susceptibility in the Chinese Han population. (2015 Jul)	Liu Q	Infect Genet Evol
29574730	Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression. (2018 Mar 25)	White PC	J Periodontal Res