Gene: RNF145

153830
-
ring finger protein 145
protein-coding
5q33.3
Ensembl:ENSG00000145860 Vega:OTTHUMG00000130306 UniprotKB:Q96MT1
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.037e-1 (AD)  6.489e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16608498chr5:158612132RNF1453.700e-8Smoking27651444
cg26403843chr5:158634085RNF1455.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP500.931
UBP10.931
NMT20.929
B4GALT50.927
AFTPH0.926
MAPK140.926
PRDM40.926
KPNA60.926
UBQLN10.925
POLR2B0.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.544
OR4F29-0.518
PON1-0.362
S100A1-0.357
ASB4-0.353
NXNL1-0.348
ENDOU-0.337
HEY2-0.336
SLC22A6-0.329
MYOM1-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of RNF145 mRNA26821219
D000082AcetaminophenAcetaminophen affects the expression of RNF145 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RNF145 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RNF145 gene27153756
C430898AGN 194204AGN 194204 results in increased expression of RNF145 mRNA16339527
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RNF145 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of RNF145 mRNA"25757056
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RNF145 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RNF145 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RNF145 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RNF145 mRNA"19150397|2038263
D004958EstradiolEstradiol results in decreased expression of RNF145 mRNA19167446
C044887beta-methylcholinebeta-methylcholine affects the expression of RNF145 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of RNF145 mRNA25270620
C006780bisphenol Abisphenol A results in increased expression of RNF145 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RNF145 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RNF145 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of RNF145 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RNF145 mRNA21297351
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RNF145 mRNA27339419
D019327Copper SulfateCopper Sulfate results in decreased expression of RNF145 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of RNF145 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of RNF145 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RNF145 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RNF145 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of RNF145 mRNA28962523
D004026DieldrinDieldrin results in increased expression of RNF145 mRNA20438755
D002117CalcitriolCalcitriol results in increased expression of RNF145 mRNA16002434
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of RNF145 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of RNF145 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of RNF145 mRNA23649840
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of RNF145 mRNA25270620
D007213IndomethacinIndomethacin results in decreased expression of RNF145 mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RNF145 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF145 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RNF145 mRNA28628672
C410337K 7174K 7174 results in increased expression of RNF145 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of RNF145 mRNA25270620
D008345ManganeseManganese results in increased expression of RNF145 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of RNF145 mRNA17175027
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RNF145 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RNF145 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RNF145 mRNA"25554681|2562005
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of RNF145 mRNA26821219
D009538NicotineNicotine results in decreased expression of RNF145 mRNA17456735
D010100OxygenOxygen deficiency results in increased expression of RNF145 mRNA17175027
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of RNF145 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of RNF145 mRNA19270015|1948288
D011374ProgesteroneProgesterone results in decreased expression of RNF145 mRNA23012394
D012402RotenoneRotenone results in decreased expression of RNF145 mRNA19013527
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RNF145 mRNA23806026
C017947sodium arsenitesodium arsenite results in increased expression of RNF145 mRNA28595984
D013629TamoxifenTamoxifen results in increased expression of RNF145 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RNF145 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RNF145 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of RNF145 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RNF145 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RNF145 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF145 mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased expression of RNF145 mRNA25549359
D014241TrichloroethyleneTrichloroethylene results in increased methylation of RNF145 gene27618143
D014415TunicamycinTunicamycin results in decreased expression of RNF145 mRNA22378314
D014520UrethaneUrethane results in decreased expression of RNF145 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RNF145 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of RNF145 gene29154799
D014635Valproic AcidValproic Acid affects the expression of RNF145 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RNF145 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28139377CPT1A methylation is associated with plasma adiponectin. (2017 Mar)Aslibekyan SNutr Metab Cardiovasc Dis