Gene info: ID 154

Gene: ADRB2

GENE ID: 154

Synonyms: ADRB2R|ADRBR|B2AR|BAR|BETA2AR

Description: adrenoceptor beta 2

Gene type: protein-coding

Location: 5q32

dbXrefs: Ensembl:ENSG00000169252 MIM:109690 Vega:OTTHUMG00000129933 UniprotKB:P07550

RefSeq: NG_016421.1

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 25

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.971e-1 (AD) 5.768e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1042718	chr5:148827354 (GRCh38.p7)	C>A / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1042717	chr5:148827083 (GRCh38.p7)	G>A / G>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CASP1	0.776
ITPRIPL2	0.762
TRIM38	0.752
CARD6	0.752
ABCC4	0.751
PLCG2	0.745
GIMAP2	0.741
ADPRH	0.741
ADAP2	0.735
CARD8	0.729

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CHST8	-0.507
DLK2	-0.484
ATOH7	-0.473
SLC7A4	-0.46
TMEM179	-0.459
GALNT14	-0.456
BCL11A	-0.455
RS1	-0.451
ISLR2	-0.448
SMIM18	-0.444

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00127	Spermine	Small Molecule	71-44-3	Approved\|Nutraceutical	Target
DB00195	Betaxolol	Small Molecule	63659-18-7	Approved\|Investigational	Target
DB00221	Isoetarine	Small Molecule	79490-84-9	Approved	Target
DB00248	Cabergoline	Small Molecule	81409-90-7	Approved	Target
DB00264	Metoprolol	Small Molecule	51384-51-1	Approved\|Investigational	Target
DB00335	Atenolol	Small Molecule	29122-68-7	Approved	Target
DB00368	Norepinephrine	Small Molecule	51-41-2	Approved	Target
DB00370	Mirtazapine	Small Molecule	85650-52-8	Approved	Target
DB00373	Timolol	Small Molecule	26839-75-8	Approved	Target
DB00397	Phenylpropanolamine	Small Molecule	14838-15-4	Approved\|Withdrawn	Target
DB00449	Dipivefrin	Small Molecule	52365-63-6	Approved	Target
DB00489	Sotalol	Small Molecule	3930-20-9	Approved	Target
DB00521	Carteolol	Small Molecule	51781-06-7	Approved	Target
DB00571	Propranolol	Small Molecule	525-66-6	Approved\|Investigational	Target
DB00598	Labetalol	Small Molecule	36894-69-6	Approved	Target
DB00612	Bisoprolol	Small Molecule	66722-44-9	Approved	Target
DB00668	Epinephrine	Small Molecule	51-43-4	Approved	Target
DB00816	Orciprenaline	Small Molecule	586-06-1	Approved	Target
DB00841	Dobutamine	Small Molecule	34368-04-2	Approved	Target
DB00852	Pseudoephedrine	Small Molecule	90-82-4	Approved	Target
DB00866	Alprenolol	Small Molecule	13655-52-2	Approved\|Withdrawn	Target
DB00867	Ritodrine	Small Molecule	26652-09-5	Approved\|Investigational	Target
DB00871	Terbutaline	Small Molecule	23031-25-6	Approved	Target
DB00901	Bitolterol	Small Molecule	30392-40-6	Withdrawn	Target
DB00925	Phenoxybenzamine	Small Molecule	59-96-1	Approved	Target
DB00938	Salmeterol	Small Molecule	89365-50-4	Approved	Target
DB00960	Pindolol	Small Molecule	13523-86-9	Approved\|Investigational	Target
DB00983	Formoterol	Small Molecule	73573-87-2	Approved\|Investigational	Target
DB01001	Salbutamol	Small Molecule	18559-94-9	Approved	Target
DB01064	Isoprenaline	Small Molecule	7683-59-2	Approved\|Investigational	Target
DB01102	Arbutamine	Small Molecule	128470-16-6	Approved	Target
DB01136	Carvedilol	Small Molecule	72956-09-3	Approved\|Investigational	Target
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Target
DB01182	Propafenone	Small Molecule	54063-53-5	Approved	Target
DB01193	Acebutolol	Small Molecule	37517-30-9	Approved\|Investigational	Target
DB01203	Nadolol	Small Molecule	42200-33-9	Approved	Target
DB01210	Levobunolol	Small Molecule	47141-42-4	Approved	Target
DB01214	Metipranolol	Small Molecule	22664-55-7	Approved	Target
DB01274	Arformoterol	Small Molecule	67346-49-0	Approved\|Investigational	Target
DB01288	Fenoterol	Small Molecule	13392-18-2	Approved\|Investigational	Target
DB01291	Pirbuterol	Small Molecule	38677-81-5	Approved	Target
DB01295	Bevantolol	Small Molecule	59170-23-9	Approved	Target
DB01359	Penbutolol	Small Molecule	38363-40-5	Approved\|Investigational	Target
DB01363	Ephedra	Small Molecule	-	Approved\|Nutraceutical\|Withdrawn	Target
DB01366	Procaterol	Small Molecule	72332-33-3	Approved\|Investigational	Target
DB01407	Clenbuterol	Small Molecule	37148-27-9	Approved\|Investigational	Target
DB01408	Bambuterol	Small Molecule	81732-65-2	Approved\|Investigational	Target
DB01580	Oxprenolol	Small Molecule	6452-71-7	Approved	Target
DB01917	Putrescine	Small Molecule	110-60-1	Experimental	Target
DB03566	Spermidine	Small Molecule	124-20-9	Experimental	Target
DB04846	Celiprolol	Small Molecule	56980-93-9	Approved\|Investigational	Target
DB04861	Nebivolol	Small Molecule	118457-14-0	Approved\|Investigational	Target
DB05039	Indacaterol	Small Molecule	312753-06-3	Approved	Target
DB05849	NCX 950	Small Molecule	-	Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB06262	Droxidopa	Small Molecule	23651-95-8	Approved\|Investigational	Target
DB06814	Protokylol	Small Molecule	136-70-9	Approved	Target
DB07543	(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol	Small Molecule		Experimental	Target
DB08807	Bopindolol	Small Molecule	62658-63-3	Approved	Target
DB08808	Bupranolol	Small Molecule	14556-46-8	Approved	Target
DB09013	Befunolol	Small Molecule	39552-01-7	Experimental	Target
DB09080	Olodaterol	Small Molecule	868049-49-4	Approved	Target
DB09082	Vilanterol	Small Molecule	503068-34-6	Approved	Target
DB09204	Arotinolol	Small Molecule	68377-92-4	Investigational	Target
DB09273	Doxofylline	Small Molecule	69975-86-6	Approved\|Investigational	Target
DB11124	Racepinephrine	Small Molecule	329-65-7	Approved	Target
DB12248	Tulobuterol	Small Molecule	41570-61-0	Investigational	Target
DB13139	Levosalbutamol	Small Molecule	34391-04-3	Approved\|Investigational	Target
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Target
DB00217	Bethanidine	Small Molecule	55-73-2	Approved	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00726	Trimipramine	Small Molecule	739-71-9	Approved	Target
DB01365	Mephentermine	Small Molecule	100-92-5	Approved	Target
DB06726	Bufuralol	Small Molecule	54340-62-4	Experimental\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of ADRB2 mRNA"	26377693
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of ADRB2 mRNA	23792671
C032668	1-nitropyrene	ADRB2 protein promotes the reaction [1-nitropyrene results in increased secretion of CXCL8 protein]	24904980
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ADRB2 mRNA	19933214
C012796	2-butenal	2-butenal results in decreased expression of ADRB2 mRNA	20471460
C010076	2-chloroethylamine	2-chloroethylamine analog results in decreased activity of ADRB2 protein	11886792
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide affects the localization of and results in increased degradation of ADRB2 protein	19202564
C097869	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [cyanopindolol binds to ADRB2 protein]"	14730417
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADRB2 mRNA"	23196670
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ADRB2 mRNA	16788091
C085755	4-(1H-imidazol-4-ylmethyl)piperidine	4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of ADRB2 mRNA"	26186136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADRB2 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of ADRB2 mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADRB2 mRNA"	27188386
C095427	A 86929	A 86929 binds to ADRB2 protein	8558425
D000070	Acebutolol	[Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000070	Acebutolol	[Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D000070	Acebutolol	[Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB2 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB2 mRNA]	17585979
D020106	Acrylamide	Acrylamide results in decreased expression of ADRB2 mRNA	28959563
D000242	Cyclic AMP	[Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	19419905
D000242	Cyclic AMP	ADRB2 protein affects the abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	ADRB2 protein polymorphism results in increased chemical synthesis of Cyclic AMP	21868359
D000242	Cyclic AMP	ADRB2 protein results in increased abundance of Cyclic AMP	11562432
D000242	Cyclic AMP	ADRB2 protein results in increased chemical synthesis of Cyclic AMP	21868359
D000242	Cyclic AMP	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1095268
D000242	Cyclic AMP	[Alprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	[Betaxolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Bisoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Bisoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[BRL 37344 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[broxaterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[carvedilol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[carvedilol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[CGP 12177 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[CGP 20712A binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	19419905
D000242	Cyclic AMP	[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	12920204\|1473041
D000242	Cyclic AMP	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	14730417\|1698055
D000242	Cyclic AMP	[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	16980553
D000242	Cyclic AMP	[ICI 118551 binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1292020
D000242	Cyclic AMP	[Isoproterenol results in increased activity of ADRB2 protein] which results in increased chemical synthesis of Cyclic AMP	27825928
D000242	Cyclic AMP	[Labetalol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Metaproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	16980553
D000242	Cyclic AMP	[Metoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Metoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Nadolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Norepinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Oxprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Pindolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Pindolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	[Practolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Propranolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D000242	Cyclic AMP	Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	10952688\|1292020
D000242	Cyclic AMP	Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000242	Cyclic AMP	[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1473041
D000242	Cyclic AMP	[Sotalol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1292020
D000242	Cyclic AMP	[Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D000242	Cyclic AMP	ADRB2 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]	18378355
D000242	Cyclic AMP	[Terbutaline results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10857765
D000242	Cyclic AMP	Alprenolol inhibits the reaction [[Alprenolol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	17718540
D000242	Cyclic AMP	ICI 118551 inhibits the reaction [[ICI 118551 binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	17718540
D000242	Cyclic AMP	[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	17718540
D000242	Cyclic AMP	Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	17718540
D000242	Cyclic AMP	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	17480040\|1771854
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ADRB2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ADRB2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ADRB2 mRNA	21641981
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ADRB2 mRNA	19770486
D000420	Albuterol	Albuterol results in decreased expression of ADRB2 mRNA	20840543
D000420	Albuterol	Albuterol results in decreased expression of ADRB2 protein	20840543
D000420	Albuterol	rosiglitazone inhibits the reaction [Albuterol results in decreased expression of ADRB2 protein]	20840543
D000420	Albuterol	ADRB2 gene polymorphism results in decreased susceptibility to Albuterol	15687340
D000420	Albuterol	Albuterol binds to and results in increased activity of ADRB2 protein	10516654\|1095268
D000420	Albuterol	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium	8102213
D000420	Albuterol	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1095268
D000420	Albuterol	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein	16980553
D000420	Albuterol	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein	16980553
D000420	Albuterol	Albuterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D000420	Albuterol	Albuterol results in decreased expression of ADRB2 protein	16980553
D000420	Albuterol	Albuterol results in increased phosphorylation of ADRB2 protein	14722251\|1698055
D000420	Albuterol	Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]	12920204
D000420	Albuterol	Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000420	Albuterol	ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]	12920204
D000420	Albuterol	ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D000420	Albuterol	Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]	12920204
D000420	Albuterol	Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	10952688\|1292020
D000420	Albuterol	Albuterol binds to and results in increased activity of ADRB2 protein	19120125
D000420	Albuterol	Albuterol binds to and results in increased activity of ADRB2 protein	15467267
D000420	Albuterol	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid	2463453
D000420	Albuterol	Albuterol results in increased activity of ADRB2 protein	19363516
D000420	Albuterol	Albuterol binds to and results in increased activity of ADRB2 protein	16908771\|1946296
D000447	Aldehydes	Aldehydes results in increased expression of ADRB2 mRNA	25014914
D000526	Alprenolol	[Alprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D000526	Alprenolol	[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D000526	Alprenolol	[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D000526	Alprenolol	[Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein	10455254
D000526	Alprenolol	Alprenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D000526	Alprenolol	Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]	12198331
D000526	Alprenolol	Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]	12198331
D000526	Alprenolol	Alprenolol binds to and results in increased activity of ADRB2 protein	17718540
D000526	Alprenolol	Alprenolol inhibits the reaction [[Alprenolol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	17718540
D000638	Amiodarone	Amiodarone results in decreased expression of ADRB2 protein	1653643
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ADRB2 mRNA	16483693
C032473	amosulalol	amosulalol binds to and results in decreased activity of ADRB2 protein	6129981
C076559	arbutamine	arbutamine results in increased activity of ADRB2 protein	8723169
C015001	arsenite	arsenite results in decreased methylation of ADRB2 promoter	23974009
C015001	arsenite	arsenite results in increased expression of ADRB2 mRNA	23974009
D001194	Asbestos	Asbestos results in decreased expression of ADRB2 mRNA	22398240
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of ADRB2 mRNA"	18687144\|2535159
D001241	Aspirin	ADRB2 polymorphism affects the susceptibility to Aspirin	18159608
D001241	Aspirin	ADRB2 SNP affects the susceptibility to Aspirin	18379861
D001262	Atenolol	Atenolol binds to and results in decreased activity of ADRB2 protein	12021574
D001262	Atenolol	[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D001262	Atenolol	[Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D001262	Atenolol	[Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D001262	Atenolol	Atenolol binds to and results in decreased activity of ADRB2 protein	14730417
D001262	Atenolol	[Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D001262	Atenolol	Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]	12920204
D001262	Atenolol	Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D001262	Atenolol	Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D001262	Atenolol	Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	12920204
D001262	Atenolol	Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D001262	Atenolol	Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	12920204
D001262	Atenolol	Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D001262	Atenolol	Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]	12920204
D001262	Atenolol	Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D001262	Atenolol	Atenolol results in increased expression of ADRB2 protein	6093157
D001262	Atenolol	Atenolol binds to ADRB2 protein	2462161
D001262	Atenolol	Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D001262	Atenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D001262	Atenolol	Atenolol binds to ADRB2 protein	11483288\|2462161
D001262	Atenolol	Atenolol binds to and results in decreased activity of ADRB2 protein	11425575
D001262	Atenolol	Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D001262	Atenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D001374	Azacitidine	Azacitidine affects the expression of ADRB2 mRNA	19002953
C547126	AZM551248	AZM551248 results in decreased expression of ADRB2 mRNA	22323515
C058041	B 24-76	B 24-76 results in increased activity of ADRB2 protein	2974281
D001507	Beclomethasone	Beclomethasone results in increased expression of ADRB2 mRNA	15679717\|9032216
C006034	befunolol	befunolol binds to and results in decreased activity of ADRB2 protein	11436944
C044946	benazepril	ADRB2 protein polymorphism affects the susceptibility to benazepril	15554460
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of ADRB2 mRNA	26377693
D001564	Benzo(a)pyrene	ADRB2 protein promotes the reaction [Benzo(a)pyrene results in increased transport of Calcium]	22167199
D001564	Benzo(a)pyrene	ADRB2 protein results in increased susceptibility to Benzo(a)pyrene	22167199
D001564	Benzo(a)pyrene	Benzo(a)pyrene binds to ADRB2 protein	22167199
D001564	Benzo(a)pyrene	[Benzo(a)pyrene binds to ADRB2 protein] which results in increased transport of Calcium	22167199
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of ADRB2 mRNA	26271895
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ADRB2 mRNA	21569818
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ADRB2 mRNA"	20382639
D015784	Betaxolol	[Betaxolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D015784	Betaxolol	Betaxolol binds to and results in decreased activity of ADRB2 protein	11436944
C095105	bexarotene	bexarotene results in decreased expression of ADRB2 mRNA	17178900
C053541	bicalutamide	bicalutamide inhibits the reaction [Triiodothyronine results in increased expression of ADRB2 protein]	18454446
C053541	bicalutamide	bicalutamide results in decreased expression of ADRB2 mRNA	18454446
C053541	bicalutamide	bicalutamide results in decreased expression of ADRB2 protein	18454446
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of ADRB2 mRNA	26186136
D017298	Bisoprolol	[Bisoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D017298	Bisoprolol	Bisoprolol binds to and results in decreased activity of ADRB2 protein	14730417
D017298	Bisoprolol	[Bisoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D017298	Bisoprolol	Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D017298	Bisoprolol	Bisoprolol results in increased expression of ADRB2 mRNA	20668454
C006780	bisphenol A	bisphenol A affects the expression of ADRB2 mRNA	25181051
C086232	bosentan	bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]	22483689
C057368	BRL 37344	BRL 37344 binds to and results in decreased activity of ADRB2 protein	14730417
C057368	BRL 37344	[BRL 37344 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
C057368	BRL 37344	BRL 37344 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C057368	BRL 37344	[BRL 37344 binds to and results in increased activity of ADRB2 protein] which results in increased uptake of Glucose	18552870
C057368	BRL 37344	ICI 118551 inhibits the reaction [[BRL 37344 binds to and results in increased activity of ADRB2 protein] which results in increased uptake of Glucose]	18552870
C057368	BRL 37344	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[BRL 37344 binds to and results in increased activity of ADRB3 protein] which results in decreased activity of OXT protein]	17632099
C045916	broxaterol	broxaterol binds to and results in increased activity of ADRB2 protein	14730417\|1664813
C045916	broxaterol	[broxaterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	14730417
C045916	broxaterol	broxaterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C024307	bucindolol	bucindolol results in decreased expression of ADRB2 protein	11392464
D019819	Budesonide	Budesonide results in increased expression of ADRB2 protein	20061444
D002066	Busulfan	ADRB2 protein results in decreased susceptibility to Busulfan	7202579
C048491	butaprost	butaprost results in increased expression of ADRB2 mRNA	24705868
D002078	Butoxamine	Butoxamine binds to and results in decreased activity of ADRB2 protein	11821714\|1590851
C018475	butyraldehyde	butyraldehyde results in increased expression of ADRB2 mRNA	26079696
D002087	Butyrates	Butyrates results in increased expression of ADRB2 mRNA	8120022
D002087	Butyrates	Butyrates results in increased expression of ADRB2 protein	8120022
C584509	C646 compound	C646 compound results in decreased expression of ADRB2 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ADRB2 mRNA	26472689
D002118	Calcium	ADRB2 protein promotes the reaction [Benzo(a)pyrene results in increased transport of Calcium]	22167199
D002118	Calcium	[Benzo(a)pyrene binds to ADRB2 protein] which results in increased transport of Calcium	22167199
D002118	Calcium	[Terbutaline binds to and results in increased activity of ADRB2 protein] which affects the abundance of Calcium	10372813
D002354	Carteolol	Carteolol binds to and results in decreased activity of ADRB2 protein	11436944
C043211	carvedilol	[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to carvedilol	21395649
C043211	carvedilol	ADRB2 gene SNP affects the susceptibility to carvedilol	20352314
C043211	carvedilol	ADRB2 protein polymorphism affects the susceptibility to carvedilol	12835612\|1903403
C043211	carvedilol	carvedilol binds to ADRB2 protein	10372227\|1530622
C043211	carvedilol	[carvedilol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
C043211	carvedilol	[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
C043211	carvedilol	[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
C043211	carvedilol	carvedilol binds to and results in decreased activity of ADRB2 protein	14730417\|1622585
C043211	carvedilol	[carvedilol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
C043211	carvedilol	[carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein	10455254
C043211	carvedilol	[carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein	10455254
C043211	carvedilol	carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	12535855
C043211	carvedilol	carvedilol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	12535855\|1473041
C043211	carvedilol	carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	16225854
C043211	carvedilol	carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]	17925438
C043211	carvedilol	carvedilol results in increased phosphorylation of ADRB2 protein	17925438
C043211	carvedilol	carvedilol results in increased uptake of ADRB2 protein	17925438
C043211	carvedilol	Guanine Nucleotides affects the reaction [carvedilol binds to ADRB2 protein]	1378154
C043211	carvedilol	ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]	17925438
C043211	carvedilol	ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]	17925438
C043211	carvedilol	ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]	17925438
C043211	carvedilol	Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]	17925438
C043211	carvedilol	Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein]	17925438
C043211	carvedilol	carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]	12198331
C043211	carvedilol	carvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]	12198331
C043211	carvedilol	carvedilol binds to ADRB2 protein	2462161
C043211	carvedilol	carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C043211	carvedilol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
C043211	carvedilol	carvedilol binds to ADRB2 protein	2462161
C043211	carvedilol	carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C043211	carvedilol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
C043211	carvedilol	carvedilol results in increased expression of ADRB2 mRNA	20668454\|2121683
C043211	carvedilol	carvedilol binds to and results in decreased activity of ADRB2 protein	11336626\|1290408
C033394	CGP 12177	carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	12535855
C033394	CGP 12177	CGP 12177 binds to ADRB2 protein	12535855\|2187087
C033394	CGP 12177	CGP 12177 binds to and results in decreased activity of ADRB2 protein	14730417
C033394	CGP 12177	[CGP 12177 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
C033394	CGP 12177	CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C033394	CGP 12177	"N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB2 protein]"	21870877
C033394	CGP 12177	Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	CGP 12177 binds to ADRB2 protein	2462161
C033394	CGP 12177	ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	CGP 12177 binds to ADRB2 protein	17628611\|2462161
C033394	CGP 12177	ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C033394	CGP 12177	CGP 12177 binds to and results in decreased activity of ADRB2 protein	12732361\|9024225
C049763	CGP 20712A	CGP 20712A binds to and results in decreased activity of ADRB2 protein	14730417
C049763	CGP 20712A	[CGP 20712A binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
C049763	CGP 20712A	CGP 20712A inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C049763	CGP 20712A	CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
C049763	CGP 20712A	CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
C049763	CGP 20712A	CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
C049763	CGP 20712A	CGP 20712A binds to and results in decreased activity of ADRB2 protein	12877941\|1719655
D002712	Chlorides	[Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Chlorides	20054151
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of ADRB2 mRNA	18636392
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of ADRB2 mRNA	18812211
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of ADRB2 mRNA	17452286
D002772	Cholera Toxin	Cholera Toxin affects the expression of ADRB2 mRNA	24705868
D002794	Choline	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADRB2 mRNA	25178843
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADRB2 mRNA	20938992
D002794	Choline	Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADRB2 mRNA]	25178843
D002976	Clenbuterol	[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose	18552870
D002976	Clenbuterol	ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose]	18552870
D002976	Clenbuterol	Clenbuterol binds to and results in increased activity of ADRB2 protein	16007677
D002976	Clenbuterol	Clenbuterol binds to and results in increased activity of ADRB2 protein	10898105\|1502196
C086108	clobenpropit	clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB2 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ADRB2 mRNA]	17585979
D003010	Clorgyline	Clorgyline results in increased expression of ADRB2 mRNA	19691856
D003035	Cobalt	Cobalt promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	11752207
D005576	Colforsin	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	19419905
D005576	Colforsin	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]	19419905
D005576	Colforsin	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]	19419905
D005576	Colforsin	Colforsin results in increased expression of ADRB2 mRNA	24705868
D005576	Colforsin	Colforsin results in increased phosphorylation of ADRB2 protein	14722251
D003300	Copper	Copper binds to and results in increased activity of ADRB2 protein	16567806
D003345	Corticosterone	Corticosterone results in increased expression of ADRB2 mRNA	15755911
C047975	cyanopindolol	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [cyanopindolol binds to ADRB2 protein]"	14730417
C047975	cyanopindolol	Albuterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Alprenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	BRL 37344 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	broxaterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	carvedilol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	12535855\|1473041
C047975	cyanopindolol	CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	CGP 20712A inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	cyanopindolol binds to ADRB2 protein	12535855\|1473041
C047975	cyanopindolol	Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Fenoterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Metoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Pindolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Propranolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	Terbutaline inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C047975	cyanopindolol	cyanopindolol binds to ADRB2 protein	11815381
C047975	cyanopindolol	ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	11815381
D003513	Cycloheximide	[Cycloheximide co-treated with EDN1 protein] results in increased expression of ADRB2 mRNA	22483689
D003513	Cycloheximide	Cycloheximide inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]	24705868
D003513	Cycloheximide	Cycloheximide results in increased expression of ADRB2 mRNA	24705868
D003513	Cycloheximide	Cycloheximide results in increased expression of ADRB2 protein	24705868
D003513	Cycloheximide	Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of ADRB2 protein]	24705868
D003513	Cycloheximide	Formoterol Fumarate promotes the reaction [Cycloheximide results in increased expression of ADRB2 mRNA]	24705868
D003513	Cycloheximide	N(6)-benzoyl-cyclic AMP promotes the reaction [Cycloheximide results in increased expression of ADRB2 mRNA]	24705868
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADRB2 mRNA	20106945\|2214713
D016572	Cyclosporine	Cyclosporine results in increased expression of ADRB2 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADRB2 mRNA	19770486
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of ADRB2 protein]	24705868
D003609	Dactinomycin	Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]	22483689
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]	24705868
D003634	DDT	DDT affects the activity of ADRB2 protein	17157474
C014347	decitabine	decitabine affects the expression of ADRB2 mRNA	17194187
D003671	DEET	[fipronil co-treated with DEET] results in increased expression of ADRB2 mRNA	27091632
D003907	Dexamethasone	Dexamethasone results in decreased expression of ADRB2 mRNA	15760667
D003907	Dexamethasone	Dexamethasone results in increased activity of ADRB2 protein	9032216
D003907	Dexamethasone	Dexamethasone results in increased expression of ADRB2 mRNA	9032216
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADRB2 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of ADRB2 mRNA	21804312
D003907	Dexamethasone	Dexamethasone results in increased expression of ADRB2 mRNA	9074950
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of ADRB2 mRNA]	9074950
D016264	Dextran Sulfate	[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of ADRB2 mRNA	26271895
D003976	Diazinon	Diazinon results in increased expression of ADRB2 mRNA	17452286
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of ADRB2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of ADRB2 mRNA	27392435
D004008	Diclofenac	Diclofenac results in increased expression of ADRB2 mRNA	26934552
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ADRB2 mRNA	26924002
D004026	Dieldrin	Dieldrin affects the expression of ADRB2 mRNA	18812211
D004082	Dihydroalprenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Dihydroalprenolol binds to ADRB2 protein	2462161
D004082	Dihydroalprenolol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Dihydroalprenolol binds to ADRB2 protein	2462161
D004082	Dihydroalprenolol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D004082	Dihydroalprenolol	Dihydroalprenolol binds to ADRB2 protein	15477226\|1719655
D002117	Calcitriol	Calcitriol results in decreased expression of ADRB2 mRNA	16002434
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of ADRB2 mRNA	26924002
D004280	Dobutamine	ADRB2 gene polymorphism affects the susceptibility to Dobutamine	17094270
D004280	Dobutamine	Dobutamine binds to and results in increased activity of ADRB2 protein	10630826
D007980	Levodopa	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] which affects the uptake of Levodopa	10894789
D007980	Levodopa	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]	10894789
D007980	Levodopa	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa	10894789
D004298	Dopamine	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]	10894789
D004298	Dopamine	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine	10894789
D017292	Doxazosin	Doxazosin results in increased expression of ADRB2 protein	18084315
D004317	Doxorubicin	ADRB2 affects the susceptibility to Doxorubicin	16458323
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal binds to and results in decreased activity of ADRB2 protein"	11425575
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased activity of ADRB2 protein"	19363516
C556408	elzasonan	elzasonan affects the activity of ADRB2 protein	23611293
D015773	Enalaprilat	Enalaprilat affects the expression of ADRB2 protein	9260993
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ADRB2 mRNA	22079256
D004837	Epinephrine	Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	12920204
D004837	Epinephrine	Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D004837	Epinephrine	carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	16225854
D004837	Epinephrine	Epinephrine binds to and results in increased activity of ADRB2 protein	12920204\|1473041
D004837	Epinephrine	[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	12920204\|1473041
D004837	Epinephrine	Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D004837	Epinephrine	Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]	14722251
D004837	Epinephrine	Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]	14722251
D004837	Epinephrine	Epinephrine results in increased activity of ADRB2 protein	1389726
D004837	Epinephrine	Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein	14722251
D004837	Epinephrine	ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	12920204
D004837	Epinephrine	ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D004837	Epinephrine	Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	12920204
D004837	Epinephrine	Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D004837	Epinephrine	ADRB2 affects the susceptibility to Epinephrine	16026475
D004837	Epinephrine	Epinephrine results in increased activity of ADRB2 protein	11164953
D004837	Epinephrine	[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine	11164953
D000431	Ethanol	Ethanol results in increased expression of ADRB2 mRNA	19167417
D000431	Ethanol	Ethanol affects the expression of ADRB2 mRNA	11772933
D000431	Ethanol	Ethanol results in decreased expression of ADRB2 protein	25151222
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ADRB2 mRNA	12655037\|1583489
D005039	Etilefrine	Etilefrine binds to and results in increased activity of ADRB2 protein	788908
C540355	fenamidone	fenamidone results in increased expression of ADRB2 mRNA	27029645
D005280	Fenoterol	Fenoterol binds to and results in increased activity of ADRB2 protein	14730417\|1698055
D005280	Fenoterol	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium	8102213
D005280	Fenoterol	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	14730417\|1698055
D005280	Fenoterol	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein	16980553
D005280	Fenoterol	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein	16980553
D005280	Fenoterol	Fenoterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D005280	Fenoterol	Fenoterol results in increased phosphorylation of ADRB2 protein	14722251
D005280	Fenoterol	CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D005280	Fenoterol	Fenoterol binds to and results in increased activity of ADRB2 protein	16474418
D005280	Fenoterol	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine	16474418
D005280	Fenoterol	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]	7969507
D005280	Fenoterol	Fenoterol binds to and results in increased activity of ADRB2 protein	19462961
C112517	ferulinolol	ferulinolol binds to and results in increased activity of ADRB2 protein	9593075
C112517	ferulinolol	ferulinolol binds to ADRB2 protein	9593075
C082360	fipronil	[fipronil co-treated with DEET] results in increased expression of ADRB2 mRNA	27091632
C082360	fipronil	fipronil results in increased expression of ADRB2 mRNA	27091632
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADRB2 mRNA	20938992
D004397	Fonofos	Fonofos results in increased methylation of ADRB2 promoter	22847954
D000068759	Formoterol Fumarate	Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]	24705868
D000068759	Formoterol Fumarate	Formoterol Fumarate affects the expression of ADRB2 mRNA	24705868
D000068759	Formoterol Fumarate	Formoterol Fumarate binds to and results in increased activity of ADRB2 protein	16980553
D000068759	Formoterol Fumarate	[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	16980553
D000068759	Formoterol Fumarate	[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein	16980553
D000068759	Formoterol Fumarate	[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein	16980553
D000068759	Formoterol Fumarate	Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D000068759	Formoterol Fumarate	Formoterol Fumarate promotes the reaction [Cycloheximide results in increased expression of ADRB2 mRNA]	24705868
D000068759	Formoterol Fumarate	Formoterol Fumarate results in increased phosphorylation of ADRB2 protein	14722251\|1698055
D000068759	Formoterol Fumarate	ICI 118551 inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]	24705868
D000068759	Formoterol Fumarate	Formoterol Fumarate binds to and results in increased activity of ADRB2 protein	20061444
D000068759	Formoterol Fumarate	Formoterol Fumarate binds to and results in increased activity of ADRB2 protein	16908771
C039281	furan	furan results in increased methylation of ADRB2 gene	22079235
D005947	Glucose	[BRL 37344 binds to and results in increased activity of ADRB2 protein] which results in increased uptake of Glucose	18552870
D005947	Glucose	[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose	18552870
D005947	Glucose	ICI 118551 inhibits the reaction [[BRL 37344 binds to and results in increased activity of ADRB2 protein] which results in increased uptake of Glucose]	18552870
D005947	Glucose	ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose]	18552870
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA	19695318
D006150	Guanine Nucleotides	Guanine Nucleotides affects the reaction [carvedilol binds to ADRB2 protein]	1378154
C004380	H 35-25	H 35-25 binds to and results in decreased activity of ADRB2 protein	212150
D006632	Histamine	Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
D006632	Histamine	Histamine results in increased activity of ADRB2 protein	17196553
D006632	Histamine	ADRB2 results in decreased susceptibility to Histamine	12198331
D006632	Histamine	Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]	12198331
D006632	Histamine	carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]	12198331
D006632	Histamine	ICI 118551 inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]	12198331
D006632	Histamine	[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine	11164953
D006632	Histamine	[Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine	11164953
D006632	Histamine	[Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine	11164953
D006897	Hydroxyindoleacetic Acid	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid	2463453
C026777	ICI 118551	ICI 118551 binds to and results in decreased activity of ADRB2 protein	12606629
C026777	ICI 118551	ICI 118551 binds to ADRB2 protein	10372227\|1253585
C026777	ICI 118551	[ICI 118551 binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
C026777	ICI 118551	ICI 118551 binds to and results in decreased activity of ADRB2 protein	10952688\|1473041
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]	17369603
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]	17369603
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]	17003101
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]	17003101
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]	17003101
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine	17003101\|1736960
C026777	ICI 118551	[ICI 118551 co-treated with ADRB2 protein] results in increased expression of GNAS protein	10455254
C026777	ICI 118551	[ICI 118551 co-treated with ADRB2 protein] results in increased expression of GRK2 protein	10455254
C026777	ICI 118551	ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]	12920204
C026777	ICI 118551	ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
C026777	ICI 118551	ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]	17925438
C026777	ICI 118551	ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]	17925438
C026777	ICI 118551	ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]	17925438
C026777	ICI 118551	ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
C026777	ICI 118551	ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	12920204
C026777	ICI 118551	ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
C026777	ICI 118551	ICI 118551 inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]	24705868
C026777	ICI 118551	ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB2 protein]	10344530
C026777	ICI 118551	ICI 118551 inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	12920204\|1603622
C026777	ICI 118551	ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
C026777	ICI 118551	ICI 118551 inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]	24705868
C026777	ICI 118551	ICI 118551 inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]	12920204
C026777	ICI 118551	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
C026777	ICI 118551	ICI 118551 inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]	12198331
C026777	ICI 118551	ICI 118551 inhibits the reaction [[BRL 37344 binds to and results in increased activity of ADRB2 protein] which results in increased uptake of Glucose]	18552870
C026777	ICI 118551	ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose]	18552870
C026777	ICI 118551	ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein]	18820136
C026777	ICI 118551	ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB2 protein]	11815381
C026777	ICI 118551	ICI 118551 binds to ADRB2 protein	2462161
C026777	ICI 118551	ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C026777	ICI 118551	ICI 118551 binds to ADRB2 protein	2462161
C026777	ICI 118551	ICI 118551 binds to and results in decreased activity of ADRB2 protein	10344530\|1089478
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]	7969507
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] which affects the uptake of Levodopa	10894789
C026777	ICI 118551	ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
C026777	ICI 118551	ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB2 protein]	9260993
C026777	ICI 118551	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]	10894789
C026777	ICI 118551	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]	10894789
C026777	ICI 118551	ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]	20054151
C026777	ICI 118551	ICI 118551 binds to and results in decreased activity of ADRB2 protein	10577992\|1180499
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[BRL 37344 binds to and results in increased activity of ADRB3 protein] which results in decreased activity of OXT protein]	17632099
C026777	ICI 118551	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[Ritodrine binds to and results in increased activity of ADRB2 protein] which results in decreased activity of OXT protein]	17632099
C026777	ICI 118551	ICI 118551 inhibits the reaction [[ICI 118551 binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	17718540
C026777	ICI 118551	ICI 118551 results in decreased activity of ADRB2 protein	14732211\|2157096
C029899	imidazole	imidazole promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
D007099	Imipramine	Imipramine results in decreased expression of ADRB2 protein	10618463
D020120	Iodocyanopindolol	ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB2 protein]	10344530
D020120	Iodocyanopindolol	Iodocyanopindolol binds to ADRB2 protein	10344530
D020120	Iodocyanopindolol	ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB2 protein]	9260993
D020120	Iodocyanopindolol	Iodocyanopindolol binds to ADRB2 protein	9260993
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADRB2 mRNA	25613284
C014898	IPS 339	IPS 339 results in decreased activity of ADRB2 protein	6103674
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine results in decreased expression of ADRB2 mRNA	24705868
D015056	1-Methyl-3-isobutylxanthine	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	19419905
D015056	1-Methyl-3-isobutylxanthine	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]	19419905
D015056	1-Methyl-3-isobutylxanthine	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]	19419905
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADRB2 mRNA	16054899
D007545	Isoproterenol	4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
D007545	Isoproterenol	Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	12920204
D007545	Isoproterenol	Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D007545	Isoproterenol	clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
D007545	Isoproterenol	Cobalt promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	11752207
D007545	Isoproterenol	Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
D007545	Isoproterenol	ICI 118551 inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	12920204\|1603622
D007545	Isoproterenol	ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D007545	Isoproterenol	imidazole promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	17196553
D007545	Isoproterenol	Isoproterenol affects the expression of ADRB2 mRNA	24705868
D007545	Isoproterenol	[Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D007545	Isoproterenol	[Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D007545	Isoproterenol	Isoproterenol binds to and results in increased activity of ADRB2 protein	10516654\|1292020
D007545	Isoproterenol	[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1292020
D007545	Isoproterenol	[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein	16980553
D007545	Isoproterenol	[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein	16980553
D007545	Isoproterenol	Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D007545	Isoproterenol	Isoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]	17925438
D007545	Isoproterenol	Isoproterenol results in increased activity of ADRB2 protein	21629661\|2782592
D007545	Isoproterenol	[Isoproterenol results in increased activity of ADRB2 protein] which results in increased chemical synthesis of Cyclic AMP	27825928
D007545	Isoproterenol	Isoproterenol results in increased expression of ADRB2 mRNA	19483313
D007545	Isoproterenol	Isoproterenol results in increased phosphorylation of ADRB2 protein	16980553
D007545	Isoproterenol	Isoproterenol results in increased uptake of ADRB2 protein	17925438
D007545	Isoproterenol	Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]	10226872
D007545	Isoproterenol	Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	12920204
D007545	Isoproterenol	Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D007545	Isoproterenol	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol	10226872
D007545	Isoproterenol	Zinc promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	11752207
D007545	Isoproterenol	ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]	15178407
D007545	Isoproterenol	CAV1 protein promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]	18820136
D007545	Isoproterenol	[GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein	9875846
D007545	Isoproterenol	ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein]	18820136
D007545	Isoproterenol	Isoproterenol results in decreased expression of ADRB2	12963636
D007545	Isoproterenol	Isoproterenol results in decreased expression of ADRB2 mRNA	17350036
D007545	Isoproterenol	Isoproterenol results in increased activity of ADRB2 protein	18820136\|2117728
D007545	Isoproterenol	ADRB2 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]	18378355
D007545	Isoproterenol	Isoproterenol results in increased activity of ADRB2 protein	11164953
D007545	Isoproterenol	[Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine	11164953
D007545	Isoproterenol	Isoproterenol binds to and results in increased activity of ADRB2 protein	15710352\|1771854
D007545	Isoproterenol	[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	17718540
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of ADRB2 mRNA	27392435
D007665	Ketotifen	Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]	10226872
C466918	KMUP 880602	KMUP 880602 binds to and results in decreased activity of ADRB2 protein	12021574
D007741	Labetalol	Labetalol binds to and results in decreased activity of ADRB2 protein	12021574
D007741	Labetalol	[Labetalol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D007741	Labetalol	[Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D007741	Labetalol	[Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D007741	Labetalol	Labetalol results in decreased activity of ADRB2 protein	2567112
D007741	Labetalol	Labetalol binds to ADRB2 protein	2462161
D007741	Labetalol	Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D007741	Labetalol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D007741	Labetalol	Labetalol binds to ADRB2 protein	11483288\|2462161
D007741	Labetalol	Labetalol binds to and results in decreased activity of ADRB2 protein	11425575
D007741	Labetalol	Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D007741	Labetalol	Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D008055	Lipids	ADRB2 gene polymorphism affects the reaction [Terbutaline results in increased metabolism of Lipids]	11429395
D008055	Lipids	ADRB2 protein affects the metabolism of Lipids	15798957
D008055	Lipids	ADRB2 protein promotes the reaction [Terbutaline results in increased metabolism of Lipids]	11429395
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ADRB2 mRNA"	18930950
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]	9258252
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ADRB2 mRNA	12057914
D008070	Lipopolysaccharides	ADRB2 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	10469353
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	10525314
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]	10525314
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]	10469353
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]	10469353
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]	11096136
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]	11096136
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]	10857765\|1109613
D008070	Lipopolysaccharides	ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]	11096136
D008070	Lipopolysaccharides	ADRB2 protein results in decreased susceptibility to Lipopolysaccharides	15021963
D019808	Losartan	Losartan affects the expression of ADRB2 protein	9260993
D009921	Metaproterenol	Metaproterenol affects the expression of ADRB2 mRNA	24705868
D009921	Metaproterenol	Metaproterenol binds to and results in increased activity of ADRB2 protein	16980553
D009921	Metaproterenol	[Metaproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	16980553
D009921	Metaproterenol	Metaproterenol results in decreased expression of ADRB2 protein	16980553
D009921	Metaproterenol	Metaproterenol results in increased phosphorylation of ADRB2 protein	16980553
D009921	Metaproterenol	Metaproterenol binds to and results in increased activity of ADRB2 protein	15052282
D008688	Methacholine Compounds	ADRB2 protein affects the susceptibility to Methacholine Compounds	10926562
D008715	Methionine	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADRB2 mRNA	25178843
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADRB2 mRNA	20938992
D008715	Methionine	Methionine deficiency results in increased expression of ADRB2 mRNA	25178843
D008715	Methionine	Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADRB2 mRNA]	25178843
D008727	Methotrexate	Methotrexate results in increased expression of ADRB2 mRNA	24449571
D008731	Methoxychlor	Methoxychlor results in increased methylation of ADRB2 gene	23303685
D008790	Metoprolol	ADRB2 gene polymorphism affects the susceptibility to Metoprolol	17671401
D008790	Metoprolol	[Metoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D008790	Metoprolol	Metoprolol binds to and results in decreased activity of ADRB2 protein	14730417
D008790	Metoprolol	[Metoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D008790	Metoprolol	Metoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D008790	Metoprolol	Metoprolol results in increased expression of ADRB2 mRNA	20675662
D008790	Metoprolol	Metoprolol binds to ADRB2 protein	9593075
D008790	Metoprolol	Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB2 protein]	18703049
D008790	Metoprolol	Metoprolol results in increased expression of ADRB2 protein	18703049
D008790	Metoprolol	Metoprolol binds to and results in decreased activity of ADRB2 protein	10353628\|1848636
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of ADRB2 mRNA]	9074950
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ADRB2 mRNA	26924002
C568515	N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide	"N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide binds to and results in decreased activity of ADRB2 protein"	21870877
C568515	N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide	"N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB2 protein]"	21870877
C435583	N-(4-(2-hydroxy-3-(2-methoxy-1-oxyethylaminobenzene)propoxy))benzaldehyde	N-(4-(2-hydroxy-3-(2-methoxy-1-oxyethylaminobenzene)propoxy))benzaldehyde binds to ADRB2 protein	11483288
C050086	N(6)-benzoyl-cyclic AMP	N(6)-benzoyl-cyclic AMP promotes the reaction [Cycloheximide results in increased expression of ADRB2 mRNA]	24705868
D009248	Nadolol	[Nadolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D009248	Nadolol	Nadolol binds to and results in decreased activity of ADRB2 protein	11577025\|1762277
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of ADRB2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ADRB2 mRNA"	25554681
D009532	Nickel	Nickel affects the expression of ADRB2 mRNA	18812211
C028007	nickel monoxide	nickel monoxide results in decreased expression of ADRB2 mRNA	19167457
D009538	Nicotine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]	17369603
D009538	Nicotine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]	17369603
D009538	Nicotine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]	17003101
D009538	Nicotine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]	17003101
D009538	Nicotine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]	17003101
D009538	Nicotine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine	17003101\|1736960
D009538	Nicotine	Nicotine results in increased expression of ADRB2 mRNA	17369603
D009569	Nitric Oxide	ADRB2 protein results in decreased abundance of Nitric Oxide	10580815
D009638	Norepinephrine	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine	2884805
D009638	Norepinephrine	Norepinephrine results in decreased expression of ADRB2 protein	11392464
D009638	Norepinephrine	Norepinephrine binds to ADRB2 protein	24929186
D009638	Norepinephrine	Norepinephrine binds to and results in increased activity of ADRB2 protein	10344530\|1473041
D009638	Norepinephrine	[Norepinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	14730417
D009638	Norepinephrine	Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D009638	Norepinephrine	Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein]	10344530
D009638	Norepinephrine	Propranolol inhibits the reaction [Norepinephrine binds to ADRB2 protein]	24929186
D009638	Norepinephrine	quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]	24929186
D009638	Norepinephrine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]	7969507
D009655	Octopamine	Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein]	10344530
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of ADRB2 mRNA	20184727
C549647	olodaterol	Cycloheximide inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]	24705868
C549647	olodaterol	EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]	22483689
C549647	olodaterol	ICI 118551 inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]	24705868
C549647	olodaterol	olodaterol affects the expression of ADRB2 mRNA	24705868
C549647	olodaterol	olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]	22483689
C549647	olodaterol	olodaterol results in increased expression of ADRB2 mRNA	22483689
C549647	olodaterol	olodaterol binds to and results in increased activity of ADRB2 protein	22483689
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of ADRB2 mRNA	24888373
D009966	Orphenadrine	Orphenadrine affects the expression of ADRB2 mRNA	23665939
D010096	Oxprenolol	[Oxprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D010096	Oxprenolol	[Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D010096	Oxprenolol	[Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D010096	Oxprenolol	Oxprenolol results in decreased activity of ADRB2	2565392
D010100	Oxygen	Oxygen affects the reaction [AHR protein results in increased expression of ADRB2 mRNA]	27103661
D010100	Oxygen	Oxygen results in decreased expression of ADRB2 protein	19098126
D010126	Ozone	ADRB2 protein affects the susceptibility to Ozone	10926562
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of ADRB2 mRNA	18636392
D010278	Parathion	Parathion results in increased methylation of ADRB2 promoter	22847954
D052638	Particulate Matter	Particulate Matter results in increased expression of ADRB2 mRNA	28412507
D052638	Particulate Matter	Particulate Matter results in increased expression of ADRB2 mRNA	28655636
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ADRB2 mRNA	26705709
C046012	pentanal	pentanal results in increased expression of ADRB2 mRNA	26079696
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ADRB2 mRNA	19162173
D037342	Pertussis Toxin	Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D037342	Pertussis Toxin	Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D015232	Dinoprostone	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]	17369603
D010656	Phenylephrine	CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D010656	Phenylephrine	CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D010656	Phenylephrine	CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D010656	Phenylephrine	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine	16474418
D010656	Phenylephrine	Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D010656	Phenylephrine	Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D010656	Phenylephrine	[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine	16474418
D010656	Phenylephrine	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine	16474418
D010852	Picrotoxin	Picrotoxin results in increased expression of ADRB2 mRNA	15170462
D010869	Pindolol	[Pindolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D010869	Pindolol	[Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D010869	Pindolol	[Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D010869	Pindolol	Pindolol binds to and results in decreased activity of ADRB2 protein	14730417
D010869	Pindolol	[Pindolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D010869	Pindolol	Pindolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D010869	Pindolol	Pindolol results in decreased expression of ADRB2 protein	2175014
D010869	Pindolol	Pindolol binds to ADRB2 protein	2462161
D010869	Pindolol	Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D010869	Pindolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D010869	Pindolol	Pindolol binds to ADRB2 protein	2462161
D010869	Pindolol	Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D010869	Pindolol	Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D010869	Pindolol	Pindolol binds to and results in decreased activity of ADRB2 protein	2205704
C009118	pirbuterol	pirbuterol binds to and results in increased activity of ADRB2 protein	6706438
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ADRB2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of ADRB2 mRNA	18445702
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of ADRB2 mRNA	24454363
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of ADRB2 mRNA	24888373
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA	19695318
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of ADRB2 mRNA	24583197
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in decreased expression of ADRB2 mRNA	27989595
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of ADRB2 mRNA	27989595
D011188	Potassium	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium	8102213
D011188	Potassium	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]	19419905
D011188	Potassium	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium	8102213
D011188	Potassium	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Potassium	17292646
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ADRB2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of ADRB2 mRNA	22079256
D011217	Practolol	[Practolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	17925438
D011217	Practolol	[Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D011217	Practolol	[Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D017265	Procaterol	Procaterol binds to and results in increased activity of ADRB2 protein	12606629
D017265	Procaterol	Procaterol binds to and results in increased activity of ADRB2 protein	9024225
D011374	Progesterone	Progesterone results in increased expression of ADRB2 mRNA	20631399
D011374	Progesterone	Progesterone results in increased expression of ADRB2 mRNA	15985637\|2072685
D011405	Propafenone	Propafenone binds to and results in decreased activity of ADRB2 protein	6141285
C005556	propionaldehyde	propionaldehyde results in increased expression of ADRB2 mRNA	26079696
D011433	Propranolol	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine	2884805
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB2 protein	12021574\|9593075
D011433	Propranolol	Propranolol binds to ADRB2 protein	10372227\|2169833
D011433	Propranolol	[Propranolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D011433	Propranolol	[Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	17925438
D011433	Propranolol	[Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	17925438
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB2 protein	10952688\|1473041
D011433	Propranolol	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	14730417
D011433	Propranolol	[Propranolol co-treated with ADRB2 protein] results in increased expression of GNAS protein	10455254
D011433	Propranolol	[Propranolol co-treated with ADRB2 protein] results in increased expression of GRK2 protein	10455254
D011433	Propranolol	Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]	12920204
D011433	Propranolol	Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	10952688\|1292020
D011433	Propranolol	Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]	17925438
D011433	Propranolol	Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein]	17925438
D011433	Propranolol	Propranolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D011433	Propranolol	Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]	12920204
D011433	Propranolol	Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D011433	Propranolol	Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	12920204
D011433	Propranolol	Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D011433	Propranolol	Propranolol inhibits the reaction [Norepinephrine binds to ADRB2 protein]	24929186
D011433	Propranolol	Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]	12920204
D011433	Propranolol	Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D011433	Propranolol	Propranolol results in decreased expression of ADRB2 mRNA	15603589
D011433	Propranolol	Propranolol binds to ADRB2 protein	2462161
D011433	Propranolol	Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D011433	Propranolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D011433	Propranolol	Propranolol binds to ADRB2 protein	11483288\|2462161
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB2 protein	11425575\|2897299
D011433	Propranolol	Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	2462161
D011433	Propranolol	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	2462161
D011433	Propranolol	Propranolol results in increased expression of ADRB2 mRNA	20668454
D011433	Propranolol	Propranolol binds to and results in decreased activity of ADRB2 protein	10556671\|1264237
D011433	Propranolol	Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	17718540
D000527	Alprostadil	Alprostadil results in increased phosphorylation of ADRB2 protein	14722251
D011700	Putrescine	Putrescine binds to and results in increased activity of ADRB2 protein	20885010
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of ADRB2 mRNA	27029645
C443401	quercetin 3-O-glucuronide	quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]	24929186
D012110	Reserpine	Reserpine results in increased expression of ADRB2 mRNA	1664493
D012312	Ritodrine	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[Ritodrine binds to and results in increased activity of ADRB2 protein] which results in decreased activity of OXT protein]	17632099
D012312	Ritodrine	Ritodrine binds to and results in increased activity of ADRB2 protein	17632099
D012312	Ritodrine	[Ritodrine binds to and results in increased activity of ADRB2 protein] which results in decreased activity of OXT protein	17632099
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Albuterol results in decreased expression of ADRB2 protein]	20840543
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADRB2 mRNA	16054899
D000068299	Salmeterol Xinafoate	[Salmeterol Xinafoate binds to ADRB2 protein] which results in increased expression of CFTR protein	12621035
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein	10516654\|1473041
D000068299	Salmeterol Xinafoate	[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1473041
D000068299	Salmeterol Xinafoate	[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein	16980553
D000068299	Salmeterol Xinafoate	[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein	16980553
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate results in decreased expression of ADRB2 protein	16980553
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate results in increased phosphorylation of ADRB2 protein	14722251
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein	20061444
D000068299	Salmeterol Xinafoate	CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D000068299	Salmeterol Xinafoate	Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein	16474418
D000068299	Salmeterol Xinafoate	[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine	16474418
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein	12621035
D022621	Shiga Toxin	ADRB2 protein affects the reaction [Shiga Toxin results in increased expression of TNF mRNA]	11675405
D022621	Shiga Toxin	ADRB2 protein promotes the reaction [Shiga Toxin results in increased activity of MAPK1 protein]	11675405
D022621	Shiga Toxin	ADRB2 protein promotes the reaction [Shiga Toxin results in increased activity of MAPK3 protein]	11675405
D022621	Shiga Toxin	ADRB2 protein results in decreased susceptibility to Shiga Toxin	11675405
D022641	Shiga Toxin 2	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]	12826277
D022641	Shiga Toxin 2	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]	12826277
D022641	Shiga Toxin 2	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]	12826277
D022641	Shiga Toxin 2	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]	12826277
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of ADRB2 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of ADRB2 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ADRB2 mRNA	19073995
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of ADRB2 mRNA	23221170
D012964	Sodium	[Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Sodium	20054151
D053260	Soot	Soot results in increased expression of ADRB2 mRNA	26551751
D013015	Sotalol	Sotalol binds to ADRB2 protein	2169833
D013015	Sotalol	[Sotalol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D013095	Spermidine	Spermidine binds to ADRB2 protein	20885010
D013096	Spermine	Spermine binds to ADRB2 protein	20885010
D013311	Streptozocin	Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB2 protein]	18703049
D013311	Streptozocin	Streptozocin results in increased expression of ADRB2 protein	18703049
D013578	Synephrine	Synephrine results in increased activity of ADRB2 protein	19363516
D014284	Triiodothyronine	bicalutamide inhibits the reaction [Triiodothyronine results in increased expression of ADRB2 protein]	18454446
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ADRB2 mRNA	18454446
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ADRB2 protein	18454446
D013629	Tamoxifen	Tamoxifen affects the expression of ADRB2 mRNA	20937368
C012568	terbufos	terbufos results in increased methylation of ADRB2 promoter	22847954
D013726	Terbutaline	ADRB2 gene polymorphism affects the reaction [Terbutaline results in increased metabolism of Lipids]	11429395
D013726	Terbutaline	ADRB2 gene polymorphism affects the susceptibility to Terbutaline	16395068
D013726	Terbutaline	ADRB2 protein affects the susceptibility to Terbutaline	16153394
D013726	Terbutaline	ADRB2 protein polymorphism affects the susceptibility to Terbutaline	12563174
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]	9258252
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]	11675405
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline results in increased metabolism of Lipids]	11429395
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]	9277405
D013726	Terbutaline	ADRB2 protein results in increased susceptibility to Terbutaline	16395068
D013726	Terbutaline	ADRB2 protein SNP results in increased susceptibility to Terbutaline	20519311
D013726	Terbutaline	Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]	12920204
D013726	Terbutaline	Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D013726	Terbutaline	ICI 118551 inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]	12920204
D013726	Terbutaline	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D013726	Terbutaline	Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]	10226872
D013726	Terbutaline	Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]	12920204
D013726	Terbutaline	Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	12920204
D013726	Terbutaline	Terbutaline binds to and results in increased activity of ADRB2 protein	10229127\|1051665
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol	10226872
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10516654\|1292020
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Potassium	17292646
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein	16980553
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein	16980553
D013726	Terbutaline	Terbutaline inhibits the reaction [cyanopindolol binds to ADRB2 protein]	14730417
D013726	Terbutaline	Terbutaline results in decreased expression of ADRB2 protein	1280742\|16980553
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]	12826277
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]	12826277
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]	12826277
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]	12826277
D013726	Terbutaline	Terbutaline results in increased phosphorylation of ADRB2 protein	14722251\|1698055
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]	14565945
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]	14565945
D013726	Terbutaline	Terbutaline binds to and results in increased activity of ADRB2 protein	17430990\|2006144
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]	10469353
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]	10469353
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]	11096136
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]	11096136
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]	10857765\|1109613
D013726	Terbutaline	ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]	11096136
D013726	Terbutaline	CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D013726	Terbutaline	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]	10894789
D013726	Terbutaline	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]	10894789
D013726	Terbutaline	ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]	20054151
D013726	Terbutaline	Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]	16474418
D013726	Terbutaline	Terbutaline binds to ADRB2 protein	19098126
D013726	Terbutaline	Terbutaline binds to and results in increased activity of ADRB2 protein	10094932\|1019228
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which affects the abundance of Calcium	10372813
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine	16474418
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa	10894789
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine	10894789
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein	10094932
D013726	Terbutaline	Terbutaline results in increased activity of ADRB2 protein	11164953\|2005415
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	10857765
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine	11164953
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Chlorides	20054151
D013726	Terbutaline	[Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Sodium	20054151
D013726	Terbutaline	Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	17718540
D013726	Terbutaline	Terbutaline binds to and results in increased activity of ADRB2 protein	17400887\|1748004
D013726	Terbutaline	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	17480040\|1771854
D013726	Terbutaline	Terbutaline results in increased activity of ADRB2	3957482
D013726	Terbutaline	Terbutaline results in increased activity of ADRB2 protein	1115162
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADRB2 mRNA	28011154
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ADRB2 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADRB2 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ADRB2 mRNA	19933214
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of ADRB2 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of ADRB2 protein	14722251
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADRB2 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of ADRB2 mRNA	23411599
D013999	Timolol	[Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	17925438
D013999	Timolol	Timolol binds to and results in decreased activity of ADRB2 protein	11436944
D013999	Timolol	Timolol binds to and results in decreased activity of ADRB2 protein	9088585
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ADRB2 mRNA	22363418
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ADRB2 mRNA	18087596
C542064	trantinterol	trantinterol binds to and results in increased activity of ADRB2 protein	21466844
D014212	Tretinoin	Tretinoin results in decreased expression of ADRB2 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of ADRB2 mRNA	23830798
C011559	tributyltin	tributyltin results in decreased expression of ADRB2 mRNA	28011154
C012589	trichostatin A	trichostatin A affects the expression of ADRB2 mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of ADRB2 mRNA	24935251
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ADRB2 mRNA"	18930950
C010809	tulobuterol	tulobuterol binds to and results in increased activity of ADRB2 protein	17364588
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADRB2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ADRB2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of ADRB2 mRNA	23179753\|2493525
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of ADRB2 mRNA	28655636
D014750	Vincristine	ADRB2 gene SNP results in increased susceptibility to Vincristine	21245421
C111237	vorinostat	vorinostat results in decreased expression of ADRB2 mRNA	18769122
D015032	Zinc	Zinc binds to and results in increased activity of ADRB2 protein	16567806
D015032	Zinc	Zinc promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]	11752207

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001540	amyloid-beta binding	-	IDA	20395454
GO:0004935	adrenergic receptor activity	-	IBA	21873635
GO:0004941	beta2-adrenergic receptor activity	-	IBA	21873635
GO:0004941	beta2-adrenergic receptor activity	-	IDA	15123695 19710023
GO:0004941	beta2-adrenergic receptor activity	-	NAS	20395454
GO:0005515	protein binding	-	IPI	9560162 9671706 15123695 17148612 17170700 19424180 19584355 20353789 20733053 23208550 23236378 24405750
GO:0008179	adenylate cyclase binding	-	IEA	-
GO:0015459	potassium channel regulator activity	-	IDA	12297500
GO:0042803	protein homodimerization activity	-	IDA	15123695
GO:0044877	protein-containing complex binding	-	IPI	20395454
GO:0051379	epinephrine binding	-	IBA	21873635
GO:0051380	norepinephrine binding	-	IDA	15123695

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002024	diet induced thermogenesis	-	IEA	-
GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	-	IBA	21873635
GO:0002028	regulation of sodium ion transport	-	IEA	-
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	-	IDA	15123695
GO:0006898	receptor-mediated endocytosis	-	IDA	15123695
GO:0007166	cell surface receptor signaling pathway	-	TAS	1371121
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	-	TAS	10734107
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	TAS	2823249
GO:0007190	activation of adenylate cyclase activity	-	IDA	15123695
GO:0007267	cell-cell signaling	-	IBA	21873635
GO:0008333	endosome to lysosome transport	-	TAS	9507004
GO:0009409	response to cold	-	IEA	-
GO:0010739	positive regulation of protein kinase A signaling	-	IGI	20395454
GO:0016579	protein deubiquitination	-	TAS	-
GO:0030501	positive regulation of bone mineralization	-	IEA	-
GO:0031398	positive regulation of protein ubiquitination	-	IMP	19372219
GO:0031649	heat generation	-	IEA	-
GO:0040015	negative regulation of multicellular organism growth	-	IEA	-
GO:0043410	positive regulation of MAPK cascade	-	IDA	15123695
GO:0045453	bone resorption	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0045986	negative regulation of smooth muscle contraction	-	IBA	21873635
GO:0050873	brown fat cell differentiation	-	IEA	-
GO:0061024	membrane organization	-	TAS	-
GO:0061885	positive regulation of mini excitatory postsynaptic potential	-	IEA	-
GO:0071875	adrenergic receptor signaling pathway	-	IDA	19710023
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	-	IBA	21873635
GO:0071902	positive regulation of protein serine/threonine kinase activity	-	IGI	20395454
GO:1901098	positive regulation of autophagosome maturation	-	IDA	23708524
GO:1904504	positive regulation of lipophagy	-	IDA	23708524
GO:1904646	cellular response to amyloid-beta	-	IGI	20395454
GO:1990911	response to psychosocial stress	-	TAS	20395454
GO:2000481	positive regulation of cAMP-dependent protein kinase activity	-	TAS	20395454
GO:2000969	positive regulation of AMPA receptor activity	-	IGI	20395454

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005764	lysosome	-	TAS	9507004
GO:0005768	endosome	-	TAS	10734107
GO:0005769	early endosome	-	IEA	-
GO:0005886	plasma membrane	-	IDA	9235896
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	12297500 19710023
GO:0010008	endosome membrane	-	TAS	-
GO:0016020	membrane	-	NAS	20395454
GO:0016324	apical plasma membrane	-	IEA	-
GO:0030665	clathrin-coated vesicle membrane	-	TAS	-
GO:0043235	receptor complex	-	IDA	15123695 23382219

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04144	Endocytosis
hsa04970	Salivary secretion

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390696	Adrenoceptors	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20546196	Association between beta-adrenoceptor gene polymorphisms and relative response to beta 2-agonists and anticholinergic drugs in Japanese asthmatic patients. (2010 Jul)	Asano K	Respirology
15469403	Pharmacogenomics and drug response in cardiovascular disorders. (2004 Oct)	Siest G	Pharmacogenomics
25909056	Association between beta2-Adrenergic Receptor-16Arg/Gly Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis. (2014 Jul)	Wang W	Iran J Public Health
18789663	CT scanning-based phenotypes vary with ADRB2 polymorphisms in chronic obstructive pulmonary disease. (2009 Jan)	Kim WJ	Respir Med
12075579	Genetic factors as predictors of weight gain in young adult Dutch men and women. (2002 Apr)	van Rossum CT	Int J Obes Relat Metab Disord
22363809	Monocyte gene expression signature of patients with early onset coronary artery disease. (2012)	Sivapalaratnam S	PLoS One
28942984	Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes. (2013)	Kaneko Y	Allergol Int
19183167	Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response. (2009 May)	Park HW	Allergy
28964817	ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema. (2018 Feb)	Nojiri M	Pulm Pharmacol Ther
17036337	Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (2006 Nov 15)	Carmichael SL	Am J Med Genet A
27091647	Neutrophilic superoxide production can assess pharmacological and pharmacogenetic beta-adrenoreceptor effects. (2016 Aug)	Reinartz MT	Allergy
12435085	A maximal effort trial in obese women carrying the beta2-adrenoceptor Gln27Glu polymorphism. (2002 Jun)	Macho-Azcarate T	J Physiol Biochem
15942941	Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms. (2005 Oct)	Masi T	Genes Chromosomes Cancer
25171434	UGT1A1*28 is associated with greater decrease in serum K(+) levels following oral intake of procaterol. (2015 Apr)	Yokoe N	J Asthma
17890463	Beta2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD. (2007 Nov)	Hizawa N	Chest
22094842	Interactive effects of main genotype, caloric intakes, and smoking status on risk of obesity. (2011)	Lee S	Asia Pac J Clin Nutr
29588580	A functional SNP upstream of the ADRB2 gene is associated with COPD. (2018)	Li JX	Int J Chron Obstruct Pulmon Dis
19111454	Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. (2009 Apr)	Kim WJ	Respir Med
18473266	Cigarette smoking, carrier state of A or G allele of 46A>G and 79C>G polymorphisms of beta2-adrenergic receptor gene, and the risk of coronary artery disease. (2008 Apr)	Zak I	Kardiol Pol
23463918	Childhood lung function and the association with beta2-adrenergic receptor haplotypes. (2013 Jul)	Torjussen TM	Acta Paediatr
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