Gene: MBOAT1

154141
LPEAT1|LPLAT|LPLAT 1|LPSAT|OACT1|dJ434O11.1
membrane bound O-acyltransferase domain containing 1
protein-coding
6p22.3
Ensembl:ENSG00000172197 MIM:611732 Vega:OTTHUMG00000014334 UniprotKB:Q6ZNC8
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
6.340e-1 (AD)  2.041e-1 (ND)   (Frontal_Cortex)
1.401e-1 (AD)  5.756e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2483767chr6:20128326 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRPM60.758
UACA0.746
FAM114A10.732
FAT40.724
VRK20.72
TMEM370.716
TANC10.714
ATP2A30.708
PRR5L0.708
SLFN50.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B3GALT1-0.482
CYP46A1-0.48
TMEM221-0.452
ST6GALNAC5-0.451
TENM2-0.442
CA7-0.44
C9orf24-0.437
RORB-0.435
CHST1-0.431
ASPDH-0.431

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of MBOAT1 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MBOAT1 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MBOAT1 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MBOAT1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MBOAT1 mRNA27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of MBOAT1 mRNA21757418
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MBOAT1 mRNA"22863853
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MBOAT1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MBOAT1 mRNA19770486|2012785
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of MBOAT1 mRNA]24758408
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of MBOAT1 mRNA20404318
D004958EstradiolEstradiol results in increased expression of MBOAT1 mRNA24758408
C006780bisphenol Abisphenol A affects the expression of MBOAT1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MBOAT1 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of MBOAT1 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of MBOAT1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MBOAT1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of MBOAT1 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of MBOAT1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of MBOAT1 mRNA20106945|2798913
D004237DiuronDiuron results in decreased expression of MBOAT1 mRNA21551480
C118739entinostatentinostat results in increased expression of MBOAT1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MBOAT1 mRNA22079256
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MBOAT1 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MBOAT1 mRNA20938992
C039281furanfuran results in increased expression of MBOAT1 mRNA27387713
C492448ICG 001ICG 001 results in increased expression of MBOAT1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MBOAT1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MBOAT1 mRNA23086925|2479639
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MBOAT1 mRNA"24972896
D008154LucanthoneLucanthone results in decreased expression of MBOAT1 mRNA21148553
D008558MelphalanMelphalan results in decreased expression of MBOAT1 mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of MBOAT1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MBOAT1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MBOAT1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MBOAT1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MBOAT1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MBOAT1 mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of MBOAT1 mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of MBOAT1 mRNA22714537
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MBOAT1 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MBOAT1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of MBOAT1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MBOAT1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MBOAT1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MBOAT1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MBOAT1 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of MBOAT1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of MBOAT1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MBOAT1 mRNA25895662
C016104sodium bichromatesodium bichromate results in increased expression of MBOAT1 mRNA22155349
D012999SomanSoman results in increased expression of MBOAT1 mRNA19281266
D053260SootSoot results in increased expression of MBOAT1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MBOAT1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MBOAT1 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MBOAT1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MBOAT1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of MBOAT1 mRNA27760801
D014212TretinoinTretinoin results in increased expression of MBOAT1 mRNA23830798
C012589trichostatin Atrichostatin A affects the expression of MBOAT1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of MBOAT1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBOAT1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MBOAT1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MBOAT1 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:00471442-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008654phospholipid biosynthetic process-IEA-  
GO:0036150phosphatidylserine acyl-chain remodeling-TAS-  
GO:0036152phosphatidylethanolamine acyl-chain remodeling-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482801Acyl chain remodelling of PSTAS
R-HSA-1482839Acyl chain remodelling of PETAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal