Gene: AMOTL1

154810
JEAP
angiomotin like 1
protein-coding
11q21
Ensembl:ENSG00000166025 MIM:614657 Vega:OTTHUMG00000167828 UniprotKB:Q8IY63
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.803e-1 (AD)  8.109e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05130679chr11:94502824AMOTL18.570e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AFAP10.79
RPS6KA30.781
VTI1A0.762
SIPA1L20.748
LGI20.747
PTPRM0.737
DCTN50.734
ZNF6410.733
ABHD20.733
PHACTR20.73

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.487
OR4F29-0.442
TPPP2-0.248
APOA1-0.245
IZUMO4-0.238
FAM186A-0.237
TNFRSF13B-0.231
FXYD3-0.23
NPIPB6-0.23
NRN1L-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMOTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMOTL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AMOTL1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AMOTL1 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AMOTL1 mRNA24449571
D001372Aza CompoundsAza Compounds results in decreased expression of AMOTL1 mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of AMOTL1 mRNA20521778
D004958EstradiolEstradiol affects the expression of AMOTL1 mRNA22574217
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of AMOTL1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of AMOTL1 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of AMOTL1 mRNA26496021
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AMOTL1 mRNA25851441
D002220CarbamazepineCarbamazepine affects the expression of AMOTL1 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AMOTL1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of AMOTL1 mRNA19320972
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AMOTL1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AMOTL1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of AMOTL1 mRNA27392435|2759478
C540355fenamidonefenamidone results in increased expression of AMOTL1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AMOTL1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of AMOTL1 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of AMOTL1 mRNA26705709
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of AMOTL1 mRNA19376150
D007211IndolesIndoles results in decreased expression of AMOTL1 mRNA20521778
D007211IndolesIndoles results in increased expression of AMOTL1 mRNA20521778
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AMOTL1 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AMOTL1 gene20938992
D008942MitoxantroneAMOTL1 mRNA affects the susceptibility to Mitoxantrone16044152
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of AMOTL1 mRNA"29244179
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMOTL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AMOTL1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of AMOTL1 mRNA20813756
C005556propionaldehydepropionaldehyde results in increased expression of AMOTL1 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of AMOTL1 mRNA27029645
C059514resveratrolresveratrol results in increased expression of AMOTL1 mRNA23750556
D012834SilverSilver results in increased expression of AMOTL1 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of AMOTL1 mRNA25879800
D043343Testosterone PropionateTestosterone Propionate results in increased expression of AMOTL1 mRNA15601916
C483909torcetrapibtorcetrapib results in increased expression of AMOTL1 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of AMOTL1 mRNA23724009
C057693troglitazonetroglitazone results in decreased expression of AMOTL1 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of AMOTL1 mRNA24383497|2493525
C025643vinclozolinvinclozolin affects the expression of AMOTL1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21187284  
GO:0042802identical protein binding-IDA16019084  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IBA21873635  
GO:0003365establishment of cell polarity involved in ameboidal cell migration-IBA21873635  
GO:0003365establishment of cell polarity involved in ameboidal cell migration-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0030334regulation of cell migration-IBA21873635  
GO:0035329hippo signaling-IBA21873635  
GO:0035329hippo signaling-TAS-  
GO:0043536positive regulation of blood vessel endothelial cell migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005923bicellular tight junction-IBA21873635  
GO:0005923bicellular tight junction-IDA16019084  
GO:0008180COP9 signalosomecolocalizes_withIDA18850735  
GO:0016324apical plasma membrane-IEA-  
GO:0030027lamellipodium-IEA-  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
hsa04530Tight junction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2028269Signaling by HippoTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27179426Mitigation of tight junction protein dysfunction in lung microvascular endothelial cells with pitavastatin. (2016 Jun)Suzuki RPulm Pharmacol Ther