Gene: CRYGN

155051
-
crystallin gamma N
protein-coding
7q36.1
Ensembl:ENSG00000127377 MIM:609603 Vega:OTTHUMG00000157353 UniprotKB:Q8WXF5
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.562e-1 (AD)  1.458e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18810691chr7:151130479CRYGN4.900e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMB30.689
IGSF220.636
DCSTAMP0.631
ADAD20.622
KERA0.615
C6orf2220.595
CTLA40.595
KDELR30.594
CCDC330.582
FCER20.573

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COLCA2-0.303
FXYD3-0.297
TBX6-0.296
C1orf229-0.29
GLIPR1L2-0.276
CDKN2C-0.276
GABRG1-0.269
EN2-0.265
ANKFN1-0.263
NPIPB6-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CRYGN protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CRYGN protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of CRYGN mRNA17562736
C103303alitretinoinalitretinoin results in decreased expression of CRYGN mRNA28689802
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CRYGN protein]26598702
C547126AZM551248AZM551248 results in increased expression of CRYGN mRNA22323515
C095105bexarotenebexarotene analog results in decreased expression of CRYGN mRNA28689802
C006780bisphenol Abisphenol A results in decreased expression of CRYGN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CRYGN gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CRYGN promoter22457795
D003300CopperCopper deficiency results in increased expression of CRYGN mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of CRYGN mRNA27523638
D019422Dietary SucroseDietary Sucrose results in increased expression of CRYGN mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CRYGN mRNA24535843
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CRYGN mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRYGN mRNA17942748
C039281furanfuran results in increased methylation of CRYGN gene22079235
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CRYGN mRNA26752646
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CRYGN mRNA"25554681
D010936Plant ExtractsPlant Extracts results in decreased expression of CRYGN mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRYGN mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRYGN mRNA17942748
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CRYGN mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CRYGN mRNA"24407104
D014635Valproic AcidValproic Acid results in increased methylation of CRYGN gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24964093Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (2014)Breton CVPLoS One