Gene info: ID 1551

Gene: CYP3A7

GENE ID: 1551

Synonyms: CP37|CYPIIIA7|P-450(HFL33)|P-450111A7|P450-HFLA

Description: cytochrome P450 family 3 subfamily A member 7

Gene type: protein-coding

Location: 7q22.1

dbXrefs: Ensembl:ENSG00000160870 MIM:605340 Vega:OTTHUMG00000156726 UniprotKB:P24462

RefSeq: NG_007983.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.007e-1 (AD) 4.245e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg04621521	chr7:99332765	CYP3A7	Promoter	2.629e-5	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HOXD12	0.58
OR12D1	0.575
OR7A17	0.575
ESCO2	0.57
OR5D14	0.543
HOXD11	0.537
GPX6	0.525
RGPD4	0.504
CWH43	0.501
USH2A	0.497

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLA2G5	-0.337
ENDOU	-0.249
CD79A	-0.241
C16orf74	-0.238
ACOX2	-0.237
JSRP1	-0.223
EMX2	-0.222
LY6K	-0.221
C22orf31	-0.22
RNASE13	-0.219

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB11994	Diacerein	Small Molecule	13739-02-1	Approved\|Investigational	Target
DB00091	Cyclosporine	Small Molecule	59865-13-3	Approved\|Investigational	Enzyme
DB00176	Fluvoxamine	Small Molecule	54739-18-3	Approved\|Investigational	Enzyme
DB00196	Fluconazole	Small Molecule	86386-73-4	Approved\|Investigational	Enzyme
DB00197	Troglitazone	Small Molecule	97322-87-7	Investigational\|Withdrawn	Enzyme
DB00199	Erythromycin	Small Molecule	114-07-8	Approved\|Investigational	Enzyme
DB00201	Caffeine	Small Molecule	58-08-2	Approved	Enzyme
DB00203	Sildenafil	Small Molecule	139755-83-2	Approved\|Investigational	Enzyme
DB00220	Nelfinavir	Small Molecule	159989-64-7	Approved	Enzyme
DB00224	Indinavir	Small Molecule	150378-17-9	Approved	Enzyme
DB00227	Lovastatin	Small Molecule	75330-75-5	Approved\|Investigational	Enzyme
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Enzyme
DB00250	Dapsone	Small Molecule	80-08-0	Approved\|Investigational	Enzyme
DB00252	Phenytoin	Small Molecule	57-41-0	Approved	Enzyme
DB00257	Clotrimazole	Small Molecule	23593-75-1	Approved	Enzyme
DB00281	Lidocaine	Small Molecule	137-58-6	Approved	Enzyme
DB00318	Codeine	Small Molecule	76-57-3	Approved\|Illicit	Enzyme
DB00333	Methadone	Small Molecule	76-99-3	Approved	Enzyme
DB00342	Terfenadine	Small Molecule	50679-08-8	Approved\|Withdrawn	Enzyme
DB00343	Diltiazem	Small Molecule	42399-41-7	Approved\|Investigational	Enzyme
DB00381	Amlodipine	Small Molecule	88150-42-9	Approved	Enzyme
DB00396	Progesterone	Small Molecule	57-83-0	Approved	Enzyme
DB00398	Sorafenib	Small Molecule	284461-73-0	Approved\|Investigational	Enzyme
DB00401	Nisoldipine	Small Molecule	63675-72-9	Approved	Enzyme
DB00404	Alprazolam	Small Molecule	28981-97-7	Approved\|Illicit\|Investigational	Enzyme
DB00425	Zolpidem	Small Molecule	82626-48-0	Approved	Enzyme
DB00439	Cerivastatin	Small Molecule	145599-86-6	Approved\|Withdrawn	Enzyme
DB00446	Chloramphenicol	Small Molecule	56-75-7	Approved	Enzyme
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Enzyme
DB00468	Quinine	Small Molecule	130-95-0	Approved	Enzyme
DB00490	Buspirone	Small Molecule	36505-84-7	Approved\|Investigational	Enzyme
DB00497	Oxycodone	Small Molecule	76-42-6	Approved\|Illicit\|Investigational	Enzyme
DB00501	Cimetidine	Small Molecule	51481-61-9	Approved\|Investigational	Enzyme
DB00502	Haloperidol	Small Molecule	52-86-8	Approved	Enzyme
DB00503	Ritonavir	Small Molecule	155213-67-5	Approved\|Investigational	Enzyme
DB00514	Dextromethorphan	Small Molecule	125-71-3	Approved	Enzyme
DB00528	Lercanidipine	Small Molecule	100427-26-7	Approved\|Investigational	Enzyme
DB00531	Cyclophosphamide	Small Molecule	50-18-0	Approved\|Investigational	Enzyme
DB00537	Ciprofloxacin	Small Molecule	85721-33-1	Approved\|Investigational	Enzyme
DB00541	Vincristine	Small Molecule	57-22-7	Approved\|Investigational	Enzyme
DB00564	Carbamazepine	Small Molecule	298-46-4	Approved\|Investigational	Enzyme
DB00571	Propranolol	Small Molecule	525-66-6	Approved\|Investigational	Enzyme
DB00582	Voriconazole	Small Molecule	137234-62-9	Approved\|Investigational	Enzyme
DB00588	Fluticasone propionate	Small Molecule	80474-14-2	Approved	Enzyme
DB00593	Ethosuximide	Small Molecule	77-67-8	Approved	Enzyme
DB00604	Cisapride	Small Molecule	81098-60-4	Approved\|Investigational\|Withdrawn	Enzyme
DB00619	Imatinib	Small Molecule	152459-95-5	Approved	Enzyme
DB00624	Testosterone	Small Molecule	58-22-0	Approved\|Investigational	Enzyme
DB00637	Astemizole	Small Molecule	68844-77-9	Approved\|Withdrawn	Enzyme
DB00641	Simvastatin	Small Molecule	79902-63-9	Approved	Enzyme
DB00647	Dextropropoxyphene	Small Molecule	469-62-5	Approved\|Illicit\|Investigational\|Withdrawn	Enzyme
DB00656	Trazodone	Small Molecule	19794-93-5	Approved\|Investigational	Enzyme
DB00661	Verapamil	Small Molecule	52-53-9	Approved	Enzyme
DB00673	Aprepitant	Small Molecule	170729-80-3	Approved\|Investigational	Enzyme
DB00675	Tamoxifen	Small Molecule	10540-29-1	Approved	Enzyme
DB00683	Midazolam	Small Molecule	59467-70-8	Approved\|Illicit	Enzyme
DB00700	Eplerenone	Small Molecule	107724-20-9	Approved	Enzyme
DB00705	Delavirdine	Small Molecule	136817-59-9	Approved	Enzyme
DB00717	Norethisterone	Small Molecule	68-22-4	Approved	Enzyme
DB00731	Nateglinide	Small Molecule	105816-04-4	Approved\|Investigational	Enzyme
DB00734	Risperidone	Small Molecule	106266-06-2	Approved\|Investigational	Enzyme
DB00741	Hydrocortisone	Small Molecule	50-23-7	Approved	Enzyme
DB00755	Tretinoin	Small Molecule	302-79-4	Approved\|Investigational\|Nutraceutical	Enzyme
DB00762	Irinotecan	Small Molecule	97682-44-5	Approved\|Investigational	Enzyme
DB00780	Phenelzine	Small Molecule	51-71-8	Approved	Enzyme
DB00783	Estradiol	Small Molecule	50-28-2	Approved\|Investigational	Enzyme
DB00802	Alfentanil	Small Molecule	71195-58-9	Approved\|Illicit	Enzyme
DB00813	Fentanyl	Small Molecule	437-38-7	Approved\|Illicit\|Investigational	Enzyme
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Enzyme
DB00834	Mifepristone	Small Molecule	84371-65-3	Approved\|Investigational	Enzyme
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Enzyme
DB00864	Tacrolimus	Small Molecule	104987-11-3	Approved\|Investigational	Enzyme
DB00877	Sirolimus	Small Molecule	53123-88-9	Approved\|Investigational	Enzyme
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Enzyme
DB00904	Ondansetron	Small Molecule	99614-02-5	Approved	Enzyme
DB00907	Cocaine	Small Molecule	50-36-2	Approved\|Illicit	Enzyme
DB00908	Quinidine	Small Molecule	56-54-2	Approved\|Investigational	Enzyme
DB00921	Buprenorphine	Small Molecule	52485-79-7	Approved\|Illicit\|Investigational	Enzyme
DB00938	Salmeterol	Small Molecule	89365-50-4	Approved	Enzyme
DB00943	Zalcitabine	Small Molecule	7481-89-2	Approved\|Investigational	Enzyme
DB00962	Zaleplon	Small Molecule	151319-34-5	Approved\|Illicit\|Investigational	Enzyme
DB00976	Telithromycin	Small Molecule	191114-48-4	Approved	Enzyme
DB01023	Felodipine	Small Molecule	72509-76-3	Approved\|Investigational	Enzyme
DB01026	Ketoconazole	Small Molecule	65277-42-1	Approved\|Investigational	Enzyme
DB01045	Rifampicin	Small Molecule	13292-46-1	Approved	Enzyme
DB01054	Nitrendipine	Small Molecule	39562-70-4	Approved\|Investigational	Enzyme
DB01058	Praziquantel	Small Molecule	55268-74-1	Approved\|Investigational	Enzyme
DB01059	Norfloxacin	Small Molecule	70458-96-7	Approved	Enzyme
DB01076	Atorvastatin	Small Molecule	134523-00-5	Approved	Enzyme
DB01100	Pimozide	Small Molecule	2062-78-4	Approved	Enzyme
DB01114	Chlorphenamine	Small Molecule	132-22-9	Approved	Enzyme
DB01115	Nifedipine	Small Molecule	21829-25-4	Approved	Enzyme
DB01118	Amiodarone	Small Molecule	1951-25-3	Approved\|Investigational	Enzyme
DB01149	Nefazodone	Small Molecule	83366-66-9	Approved\|Withdrawn	Enzyme
DB01166	Cilostazol	Small Molecule	73963-72-1	Approved\|Investigational	Enzyme
DB01167	Itraconazole	Small Molecule	84625-61-6	Approved\|Investigational	Enzyme
DB01174	Phenobarbital	Small Molecule	50-06-6	Approved\|Investigational	Enzyme
DB01181	Ifosfamide	Small Molecule	3778-73-2	Approved	Enzyme
DB01184	Domperidone	Small Molecule	57808-66-9	Approved\|Investigational	Enzyme
DB01201	Rifapentine	Small Molecule	61379-65-5	Approved\|Investigational	Enzyme
DB01211	Clarithromycin	Small Molecule	81103-11-9	Approved	Enzyme
DB01216	Finasteride	Small Molecule	98319-26-7	Approved	Enzyme
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Enzyme
DB01227	Levomethadyl Acetate	Small Molecule	1477-40-3	Approved\|Investigational	Enzyme
DB01229	Paclitaxel	Small Molecule	33069-62-4	Approved	Enzyme
DB01232	Saquinavir	Small Molecule	127779-20-8	Approved\|Investigational	Enzyme
DB01234	Dexamethasone	Small Molecule	50-02-2	Approved\|Investigational	Enzyme
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Enzyme
DB01248	Docetaxel	Small Molecule	114977-28-5	Approved\|Investigational	Enzyme
DB01268	Sunitinib	Small Molecule	557795-19-4	Approved\|Investigational	Enzyme
DB01388	Mibefradil	Small Molecule	116644-53-2	Investigational\|Withdrawn	Enzyme
DB01424	Aminophenazone	Small Molecule	58-15-1	Approved\|Withdrawn	Enzyme
DB01466	Ethylmorphine	Small Molecule	76-58-4	Approved\|Illicit	Enzyme
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Enzyme
DB04946	Iloperidone	Small Molecule	133454-47-4	Approved	Enzyme
DB05804	Prasterone sulfate	Small Molecule	651-48-9	Investigational	Enzyme
DB06287	Temsirolimus	Small Molecule	162635-04-3	Approved	Enzyme
DB06412	Oxymetholone	Small Molecule	434-07-1	Approved\|Illicit	Enzyme
DB06595	Midostaurin	Small Molecule	120685-11-2	Approved\|Investigational	Enzyme
DB06730	Gestodene	Small Molecule	60282-87-3	Approved\|Investigational	Enzyme
DB06731	Seproxetine	Small Molecule	126924-38-7	Investigational	Enzyme
DB09054	Idelalisib	Small Molecule	870281-82-6	Approved	Enzyme
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Enzyme
DB09065	Cobicistat	Small Molecule	1004316-88-4	Approved	Enzyme
DB09102	Daclatasvir	Small Molecule	1009119-64-5	Approved\|Investigational	Enzyme
DB09396	Propoxyphene napsylate	Small Molecule		Approved	Enzyme
DB11574	Elbasvir	Small Molecule	1370468-36-2	Approved	Enzyme
DB12332	Rucaparib	Small Molecule	283173-50-2	Approved\|Investigational	Enzyme
DB12483	Copanlisib	Small Molecule	1032568-63-0	Approved\|Investigational	Enzyme
DB13943	Testosterone cypionate	Small Molecule	58-20-8	Approved	Enzyme
DB13944	Testosterone enanthate	Small Molecule	315-37-7	Approved	Enzyme
DB13946	Testosterone undecanoate	Small Molecule	5949-44-0	Approved\|Investigational	Enzyme
DB13952	Estradiol acetate	Small Molecule	4245-41-4	Approved\|Investigational	Enzyme
DB13953	Estradiol benzoate	Small Molecule	50-50-0	Approved\|Investigational	Enzyme
DB13954	Estradiol cypionate	Small Molecule	313-06-4	Approved\|Investigational	Enzyme
DB13955	Estradiol dienanthate	Small Molecule	7732-97-0	Approved\|Investigational	Enzyme
DB13956	Estradiol valerate	Small Molecule	979-32-8	Approved\|Investigational	Enzyme
DB05239	Cobimetinib	Small Molecule	934660-93-2	Approved\|Investigational	Enzyme
DB06290	Simeprevir	Small Molecule	923604-59-5	Approved	Enzyme
DB08930	Dolutegravir	Small Molecule	1051375-16-6	Approved	Enzyme
DB09229	Aranidipine	Small Molecule	86780-90-7	Approved\|Investigational	Enzyme
DB09232	Cilnidipine	Small Molecule	132203-70-4	Approved\|Investigational	Enzyme
DB11605	Myrrh	Small Molecule	9000-45-7	Approved	Enzyme
DB11691	Naldemedine	Small Molecule	916072-89-4	Approved\|Investigational	Enzyme
DB13174	Rhein	Small Molecule	478-43-3	Experimental	Enzyme
DB13878	Pibrentasvir	Small Molecule	1353900-92-1	Approved\|Investigational	Enzyme
DB13879	Glecaprevir	Small Molecule	1365970-03-1	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog results in increased expression of CYP3A7 mRNA"	24273086
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of CYP3A7 mRNA"	24273086\|2472652
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in decreased expression of CYP3A7 mRNA"	26894911
C035342	1,4-naphthoquinone	"CYP3A7 protein results in increased abundance of 1,4-naphthoquinone"	16243959
C020365	17-alpha-hydroxy-progesterone caproate	CYP3A7 protein affects the metabolism of 17-alpha-hydroxy-progesterone caproate	20097724
C029350	1-naphthol	CYP3A7 protein results in increased abundance of 1-naphthol	16243959
C060080	2,2-bis(bromomethyl)-1,3-propanediol	"2,2-bis(bromomethyl)-1,3-propanediol results in decreased expression of CYP3A7 mRNA"	24273086
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased expression of CYP3A7 mRNA"	24819614
C036989	2-amino-3,4-dimethylimidazo(4,5-f)quinoline	"[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,4-dimethylimidazo(4,5-f)quinoline"	7625840
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"	7625840
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	"[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline"	7625840
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene results in decreased expression of CYP3A7 protein"	26251320
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the expression of CYP3A7 mRNA"	21703328
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of CYP3A7 mRNA	15982314
C544471	5-hydroxythalidomide	[CYP3A7 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide	20443640
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP3A7 protein"	24144921
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP3A7 protein]"	24144921
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP3A7 mRNA	26497421\|2906747
D000082	Acetaminophen	Acetaminophen results in increased expression of CYP3A7 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CYP3A7 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CYP3A7 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CYP3A7 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CYP3A7 mRNA	21632981\|2164198
D016604	Aflatoxin B1	[CYP3A7 co-treated with NAT1] results in increased susceptibility to Aflatoxin B1	7625840
D016604	Aflatoxin B1	[CYP3A7 co-treated with NAT2] results in increased susceptibility to Aflatoxin B1	7625840
D016604	Aflatoxin B1	[CYP3A7 co-treated with POR] results in increased susceptibility to Aflatoxin B1	7625840
D015760	Alfentanil	CYP3A7 protein affects the metabolism of Alfentanil	15557344
C103303	alitretinoin	alitretinoin results in decreased expression of CYP3A7 mRNA	15982314
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of CYP3A7 mRNA	21298039
D000638	Amiodarone	CYP3A7 protein results in decreased susceptibility to Amiodarone	26477383
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of CYP3A7 mRNA	22258563
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYP3A7 mRNA	21632981\|2231617
D004958	Estradiol	Estradiol results in decreased expression of CYP3A7 mRNA	17982697\|2010694
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of CYP3A7 mRNA	25470364
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of CYP3A7 mRNA	26894911
C006780	bisphenol A	bisphenol A results in decreased expression of CYP3A7 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CYP3A7 mRNA	22079614
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of CYP3A7 mRNA	26314618
D002220	Carbamazepine	Carbamazepine results in increased expression of CYP3A7 mRNA	17112801
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of CYP3A7 mRNA	15629111
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A7 mRNA	17851650
D002746	Chlorpromazine	CYP3A7 protein results in decreased susceptibility to Chlorpromazine	26477383
D004390	Chlorpyrifos	CYP3A7 protein affects the metabolism of Chlorpyrifos	17079358\|1711006
D003022	Clotrimazole	Clotrimazole results in increased expression of CYP3A7 mRNA	12673034
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CYP3A7 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYP3A7 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of CYP3A7 mRNA	12673034
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of CYP3A7 mRNA	23726867
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP3A7 protein"	8812189
D003609	Dactinomycin	Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A7 mRNA]	24819614
C010902	decabromobiphenyl ether	decabromobiphenyl ether analog results in increased expression of CYP3A7 mRNA	26894911
D003671	DEET	DEET results in increased expression of CYP3A7 mRNA	27091632
D003671	DEET	[fipronil co-treated with DEET] results in increased expression of CYP3A7 mRNA	27091632
D003687	Dehydroepiandrosterone	CYP3A7 protein affects the metabolism of Dehydroepiandrosterone	16041241
D003687	Dehydroepiandrosterone	CYP3A7 protein results in increased hydroxylation of Dehydroepiandrosterone	15845858\|1593733
D019314	Dehydroepiandrosterone Sulfate	CYP3A7 promoter polymorphism affects the abundance of Dehydroepiandrosterone Sulfate	15985487
D019314	Dehydroepiandrosterone Sulfate	CYP3A7 protein results in increased hydroxylation of Dehydroepiandrosterone Sulfate	15985487
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP3A7 mRNA	15629111
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP3A7 mRNA	19118567\|2414611
C000944	dicrotophos	dicrotophos results in decreased expression of CYP3A7 mRNA	28302478
D002117	Calcitriol	Calcitriol results in increased expression of CYP3A7 mRNA	12040012\|1600243
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide affects the expression of CYP3A7 mRNA	12843640
D004237	Diuron	Diuron results in increased expression of CYP3A7 protein	8812189
D004964	Estriol	Estriol inhibits the reaction [imidacloprid results in increased expression of CYP3A7]	28750898
D004964	Estriol	Estriol inhibits the reaction [thiacloprid results in increased expression of CYP3A7]	28750898
D004964	Estriol	Estriol inhibits the reaction [thiamethoxam results in increased expression of CYP3A7]	28750898
D004970	Estrone	CYP3A7 promoter polymorphism affects the abundance of Estrone	15985487
D004970	Estrone	CYP3A7 protein results in increased hydroxylation of Estrone	15985487
D011345	Fenofibrate	Fenofibrate results in increased expression of CYP3A7 mRNA	19118567
D005284	Fenthion	CYP3A7 protein affects the metabolism of Fenthion	17110060
C082360	fipronil	[fipronil co-treated with DEET] results in increased expression of CYP3A7 mRNA	27091632
C082360	fipronil	fipronil results in increased expression of CYP3A7 mRNA	27091632
D005938	Glucocorticoids	CYP3A7 protein results in increased metabolism of Glucocorticoids	24555085
D005938	Glucocorticoids	[[Glucocorticoids binds to NR3C1 protein] which results in increased expression of NR1I2] which results in increased expression of CYP3A7	24555085
D005938	Glucocorticoids	[[Glucocorticoids binds to NR3C1 protein] which results in increased expression of NR1I3] which results in increased expression of CYP3A7	24555085
C010178	heliotrine	heliotrine results in decreased expression of CYP3A7 mRNA	26100227
C089796	hexabromocyclododecane	hexabromocyclododecane results in increased expression of CYP3A7 mRNA	18791181\|2020021
C527454	hexachlorocyclopentadienyl-dibromocyclooctane	hexachlorocyclopentadienyl-dibromocyclooctane results in increased expression of CYP3A7 mRNA	21893176
D017313	Fenretinide	Fenretinide results in increased expression of CYP3A7 mRNA	28973697
D000068877	Imatinib Mesylate	CYP3A7 protein results in decreased methylation of Imatinib Mesylate	20977456
C082359	imidacloprid	Estriol inhibits the reaction [imidacloprid results in increased expression of CYP3A7]	28750898
C082359	imidacloprid	imidacloprid results in increased expression of CYP3A7	28750898
C011582	IMOL S-140	IMOL S-140 results in increased expression of CYP3A7 mRNA	26894911
D007213	Indomethacin	Indomethacin results in decreased expression of CYP3A7 mRNA	16771604
D001556	Lindane	Lindane results in increased expression of CYP3A7 protein	8812189
D008294	Malathion	CYP3A7 protein affects the metabolism of Malathion	17110060
C464660	obeticholic acid	obeticholic acid results in decreased expression of CYP3A7 mRNA	27939613
D009853	Omeprazole	Omeprazole results in increased expression of CYP3A7 mRNA	19118567
D010278	Parathion	CYP3A7 protein affects the metabolism of Parathion	17079358\|1711006
D010278	Parathion	Parathion results in increased expression of CYP3A7 mRNA	17982697
C506614	PD 0325901	PD 0325901 results in increased expression of CYP3A7 mRNA	24819614
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of CYP3A7 protein	8812189
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of CYP3A7 mRNA	22302310
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP3A7 mRNA]	19167519
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CYP3A7 mRNA	19167519
C023036	perfluorooctanoic acid	perfluorooctanoic acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP3A7 mRNA]	19167519
D010634	Phenobarbital	Phenobarbital affects the expression of CYP3A7 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP3A7 mRNA	19084549\|1911856
D010672	Phenytoin	Phenytoin results in increased expression of CYP3A7 mRNA	12673034
D010695	Phlorhizin	Phlorhizin results in decreased expression of CYP3A7 mRNA	22538082
D010695	Phlorhizin	Phlorhizin results in increased expression of CYP3A7 mRNA	22538082
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A7 mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP3A7 mRNA	24446304
D015474	Isotretinoin	Isotretinoin results in decreased expression of CYP3A7 mRNA	15982314
D012293	Rifampin	Rifampin results in increased expression of CYP3A7 mRNA	12673034\|1911856
C009237	senecionine	senecionine results in increased expression of CYP3A7 mRNA	26100227
C078903	seocalcitol	seocalcitol results in increased expression of CYP3A7 mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CYP3A7 mRNA	25895662
C075117	squalestatin 1	squalestatin 1 results in increased expression of CYP3A7 mRNA	15629111
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP3A7 protein"	8812189
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of CYP3A7 mRNA	23313610
D016559	Tacrolimus	CYP3A7 protein results in decreased methylation of Tacrolimus	15951320
D013739	Testosterone	CYP3A7 protein results in increased hydroxylation of Testosterone	15845858
D013749	Tetrachlorodibenzodioxin	perfluorooctane sulfonic acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP3A7 mRNA]	19167519
D013749	Tetrachlorodibenzodioxin	perfluorooctanoic acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP3A7 mRNA]	19167519
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP3A7 mRNA	19167519
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP3A7 mRNA	20106945\|2163298
D013792	Thalidomide	CYP3A7 protein results in increased hydroxylation of Thalidomide	20443640
D013792	Thalidomide	[CYP3A7 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide	20443640
C417209	thiacloprid	Estriol inhibits the reaction [thiacloprid results in increased expression of CYP3A7]	28750898
C417209	thiacloprid	thiacloprid results in increased expression of CYP3A7	28750898
C416660	thiamethoxam	Estriol inhibits the reaction [thiamethoxam results in increased expression of CYP3A7]	28750898
C416660	thiamethoxam	thiamethoxam results in increased expression of CYP3A7	28750898
D014212	Tretinoin	CYP3A7 protein affects the metabolism of Tretinoin	16041241
D014212	Tretinoin	Tretinoin metabolite results in decreased expression of CYP3A7 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of CYP3A7 mRNA	15982314
C072782	tri-(2-chloroisopropyl)phosphate	tri-(2-chloroisopropyl)phosphate results in increased expression of CYP3A7 mRNA	22268003\|2362951
C009549	triethyl phosphate	triethyl phosphate results in increased expression of CYP3A7 mRNA	24273086\|2499897
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP3A7 mRNA"	22268003\|2362951
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of CYP3A7 mRNA	24998971
C049232	tris(2-ethylhexyl)phosphate	tris(2-ethylhexyl)phosphate results in increased expression of CYP3A7 mRNA	24273086
D014317	Tritolyl Phosphates	Tritolyl Phosphates results in increased expression of CYP3A7 mRNA	24273086
C057693	troglitazone	troglitazone results in decreased expression of CYP3A7	15618651
D014217	Troleandomycin	Troleandomycin results in decreased activity of CYP3A7 protein	17207564
C113580	U 0126	Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A7 mRNA]	24819614
C113580	U 0126	U 0126 results in increased expression of CYP3A7 mRNA	24819614
D014520	Urethane	Urethane results in decreased expression of CYP3A7 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP3A7 mRNA	29154799
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of CYP3A7 mRNA	16330358
D014810	Vitamin E	Vitamin E results in decreased expression of CYP3A7 mRNA	19244175
C088658	zoledronic acid	zoledronic acid results in increased expression of CYP3A7 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004497	monooxygenase activity	-	ISS	-
GO:0004497	monooxygenase activity	-	TAS	-
GO:0005506	iron ion binding	-	IEA	-
GO:0008395	steroid hydroxylase activity	-	IDA	14559847
GO:0019825	oxygen binding	-	TAS	2722762
GO:0020037	heme binding	-	IEA	-
GO:0070330	aromatase activity	-	IEA	-
GO:0101020	estrogen 16-alpha-hydroxylase activity	-	IDA	14559847

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002933	lipid hydroxylation	-	IDA	14559847
GO:0006805	xenobiotic metabolic process	-	TAS	-
GO:0008202	steroid metabolic process	-	IDA	14559847
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0031090	organelle membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis
hsa00591	Linoleic acid metabolism
hsa00830	Retinol metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00983	Drug metabolism - other enzymes
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-211981	Xenobiotics	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23565323	Genotype and age at Parkinson disease diagnosis. (2013)	Searles Nielsen S	Int J Mol Epidemiol Genet
17334880	CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women. (2007 Mar)	Bacsi K	Calcif Tissue Int
12406645	Genetic contribution to variable human CYP3A-mediated metabolism. (2002 Nov 18)	Lamba JK	Adv Drug Deliv Rev
21715529	Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. (2011 Sep)	O'Shaughnessy PJ	J Clin Endocrinol Metab
23197595	Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)	O'Shaughnessy PJ	Mol Hum Reprod
8619884	Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. (1996 Feb 23)	Hakkola J	Biochem Pharmacol
27349315	Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma. (2016 Apr 11)	Fanni D	Eur J Histochem
9493761	Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. (1998 Jan)	Hakkola J	Crit Rev Toxicol
8694864	Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. (1996 Jul 26)	Hakkola J	Biochem Pharmacol
15698577	Regulation of CYP3A genes in the human respiratory tract. (2005 Jan 15)	Raunio H	Chem Biol Interact
23106957	In vitro characterization of the oxidation of a pyridinium metabolite of haloperidol by human placenta: the effect of smoking. (2012)	Fang J	J Pharm Pharm Sci