Gene: CYP2B6

1555
CPB6|CYP2B|CYP2B7|CYP2B7P|CYPIIB6|EFVM|IIB1|P450
cytochrome P450 family 2 subfamily B member 6
protein-coding
19q13.2
Ensembl:ENSG00000197408 MIM:123930 Vega:OTTHUMG00000182714 UniprotKB:P20813
NG_007929.1
PubMed|SNP Mapped
CD|OD|ND|AD
59   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.497e-1 (AD)  1.883e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2279343chr19:41009358 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZAN0.523
TRIM600.492
SPZ10.491
ZSCAN5C0.49
DMRTC20.486
OR6Y10.473
TDRD150.466
MBL20.461
OR2H10.46
POTEC0.45

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL22-0.267
CDH4-0.257
SH2D7-0.237
DNAH5-0.232
GDF10-0.225
IGFN1-0.224
C17orf50-0.218
CCDC13-0.216
PTX4-0.216
LCNL1-0.216

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB029744-(4-Chlorophenyl)ImidazoleSmall MoleculeExperimentalTarget
DB04664Cyclohexyl-pentyl-maltosideSmall Molecule-ExperimentalTarget
DB04794BifonazoleSmall Molecule60628-96-8Approved|InvestigationalTarget
DB083691-(biphenyl-4-ylmethyl)-1H-imidazoleSmall MoleculeExperimentalTarget
DB00169CholecalciferolSmall Molecule67-97-0Approved|NutraceuticalEnzyme
DB00176FluvoxamineSmall Molecule54739-18-3Approved|InvestigationalEnzyme
DB00184NicotineSmall Molecule54-11-5ApprovedEnzyme
DB00193TramadolSmall Molecule27203-92-5Approved|InvestigationalEnzyme
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00199ErythromycinSmall Molecule114-07-8Approved|InvestigationalEnzyme
DB00208TiclopidineSmall Molecule55142-85-3ApprovedEnzyme
DB00215CitalopramSmall Molecule59729-33-8ApprovedEnzyme
DB00220NelfinavirSmall Molecule159989-64-7ApprovedEnzyme
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalEnzyme
DB00238NevirapineSmall Molecule129618-40-2ApprovedEnzyme
DB00252PhenytoinSmall Molecule57-41-0ApprovedEnzyme
DB00257ClotrimazoleSmall Molecule23593-75-1ApprovedEnzyme
DB00281LidocaineSmall Molecule137-58-6ApprovedEnzyme
DB00285VenlafaxineSmall Molecule93413-69-5ApprovedEnzyme
DB00296RopivacaineSmall Molecule84057-95-4ApprovedEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00321AmitriptylineSmall Molecule50-48-6ApprovedEnzyme
DB00333MethadoneSmall Molecule76-99-3ApprovedEnzyme
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitEnzyme
DB00379MexiletineSmall Molecule31828-71-4Approved|InvestigationalEnzyme
DB00381AmlodipineSmall Molecule88150-42-9ApprovedEnzyme
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalEnzyme
DB00435Nitric OxideSmall Molecule10102-43-9ApprovedEnzyme
DB00439CerivastatinSmall Molecule145599-86-6Approved|WithdrawnEnzyme
DB00454PethidineSmall Molecule57-42-1ApprovedEnzyme
DB00458ImipramineSmall Molecule50-49-7ApprovedEnzyme
DB00472FluoxetineSmall Molecule54910-89-3ApprovedEnzyme
DB00481RaloxifeneSmall Molecule84449-90-1Approved|InvestigationalEnzyme
DB00503RitonavirSmall Molecule155213-67-5Approved|InvestigationalEnzyme
DB00514DextromethorphanSmall Molecule125-71-3ApprovedEnzyme
DB00515CisplatinSmall Molecule15663-27-1ApprovedEnzyme
DB00531CyclophosphamideSmall Molecule50-18-0Approved|InvestigationalEnzyme
DB00532MephenytoinSmall Molecule50-12-4Investigational|WithdrawnEnzyme
DB00564CarbamazepineSmall Molecule298-46-4Approved|InvestigationalEnzyme
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalEnzyme
DB00586DiclofenacSmall Molecule15307-86-5ApprovedEnzyme
DB00604CisaprideSmall Molecule81098-60-4Approved|Investigational|WithdrawnEnzyme
DB00622NicardipineSmall Molecule55985-32-5Approved|InvestigationalEnzyme
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalEnzyme
DB00625EfavirenzSmall Molecule154598-52-4Approved|InvestigationalEnzyme
DB00636ClofibrateSmall Molecule637-07-0Approved|InvestigationalEnzyme
DB00641SimvastatinSmall Molecule79902-63-9ApprovedEnzyme
DB00655EstroneSmall Molecule53-16-7ApprovedEnzyme
DB00661VerapamilSmall Molecule52-53-9ApprovedEnzyme
DB00675TamoxifenSmall Molecule10540-29-1ApprovedEnzyme
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitEnzyme
DB00701AmprenavirSmall Molecule161814-49-9Approved|InvestigationalEnzyme
DB00715ParoxetineSmall Molecule61869-08-7Approved|InvestigationalEnzyme
DB00745ModafinilSmall Molecule68693-11-8Approved|InvestigationalEnzyme
DB00748CarbinoxamineSmall Molecule486-16-8ApprovedEnzyme
DB00751EpinastineSmall Molecule80012-43-7Approved|InvestigationalEnzyme
DB00753IsofluraneSmall Molecule26675-46-7ApprovedEnzyme
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalEnzyme
DB00758ClopidogrelSmall Molecule113665-84-2ApprovedEnzyme
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalEnzyme
DB00763MethimazoleSmall Molecule60-56-0ApprovedEnzyme
DB00772MalathionSmall Molecule121-75-5Approved|InvestigationalEnzyme
DB00778RoxithromycinSmall Molecule80214-83-1Approved|Investigational|WithdrawnEnzyme
DB00794PrimidoneSmall Molecule125-33-7ApprovedEnzyme
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalEnzyme
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalEnzyme
DB00835BrompheniramineSmall Molecule86-22-6ApprovedEnzyme
DB00836LoperamideSmall Molecule53179-11-6ApprovedEnzyme
DB00849MethylphenobarbitalSmall Molecule115-38-8ApprovedEnzyme
DB00850PerphenazineSmall Molecule58-39-9ApprovedEnzyme
DB00865BenzphetamineSmall Molecule156-08-1Approved|IllicitEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalEnzyme
DB00972AzelastineSmall Molecule58581-89-8ApprovedEnzyme
DB00997DoxorubicinSmall Molecule23214-92-8Approved|InvestigationalEnzyme
DB01026KetoconazoleSmall Molecule65277-42-1Approved|InvestigationalEnzyme
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalEnzyme
DB01037SelegilineSmall Molecule14611-51-9Approved|InvestigationalEnzyme
DB01043MemantineSmall Molecule19982-08-2Approved|InvestigationalEnzyme
DB01045RifampicinSmall Molecule13292-46-1ApprovedEnzyme
DB01069PromethazineSmall Molecule60-87-7Approved|InvestigationalEnzyme
DB01074PerhexilineSmall Molecule6621-47-2Approved|InvestigationalEnzyme
DB01075DiphenhydramineSmall Molecule58-73-1Approved|InvestigationalEnzyme
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedEnzyme
DB01095FluvastatinSmall Molecule93957-54-1ApprovedEnzyme
DB01104SertralineSmall Molecule79617-96-2ApprovedEnzyme
DB01110MiconazoleSmall Molecule22916-47-8Approved|InvestigationalEnzyme
DB01115NifedipineSmall Molecule21829-25-4ApprovedEnzyme
DB01138SulfinpyrazoneSmall Molecule57-96-5ApprovedEnzyme
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalEnzyme
DB01156BupropionSmall Molecule34911-55-2ApprovedEnzyme
DB01159HalothaneSmall Molecule151-67-7ApprovedEnzyme
DB01167ItraconazoleSmall Molecule84625-61-6Approved|InvestigationalEnzyme
DB01173OrphenadrineSmall Molecule83-98-7ApprovedEnzyme
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalEnzyme
DB01181IfosfamideSmall Molecule3778-73-2ApprovedEnzyme
DB01184DomperidoneSmall Molecule57808-66-9Approved|InvestigationalEnzyme
DB01221KetamineSmall Molecule6740-88-1ApprovedEnzyme
DB01234DexamethasoneSmall Molecule50-02-2Approved|InvestigationalEnzyme
DB01236SevofluraneSmall Molecule28523-86-6ApprovedEnzyme
DB01320FosphenytoinSmall Molecule93390-81-9Approved|InvestigationalEnzyme
DB01394ColchicineSmall Molecule64-86-8ApprovedEnzyme
DB01435AntipyrineSmall Molecule60-80-0Approved|InvestigationalEnzyme
DB01466EthylmorphineSmall Molecule76-58-4Approved|IllicitEnzyme
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitEnzyme
DB01559ClotiazepamSmall Molecule33671-46-4Approved|IllicitEnzyme
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitEnzyme
DB01601LopinavirSmall Molecule192725-17-0ApprovedEnzyme
DB03575PhencyclidineSmall Molecule77-10-1IllicitEnzyme
DB04572ThiotepaSmall Molecule52-24-4Approved|InvestigationalEnzyme
DB04817MetamizoleSmall Molecule50567-35-6Approved|Investigational|WithdrawnEnzyme
DB04841FlunarizineSmall Molecule52468-60-7ApprovedEnzyme
DB04868NilotinibSmall Molecule641571-10-0Approved|InvestigationalEnzyme
DB04871LorcaserinSmall Molecule616202-92-7ApprovedEnzyme
DB04930PermethrinSmall Molecule52645-53-1Approved|InvestigationalEnzyme
DB04938OspemifeneSmall Molecule128607-22-7Approved|InvestigationalEnzyme
DB04975BanoxantroneSmall Molecule136470-65-0InvestigationalEnzyme
DB05219CrisaboroleSmall Molecule906673-24-3Approved|InvestigationalEnzyme
DB05541BrivaracetamSmall Molecule357336-20-0Approved|InvestigationalEnzyme
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalEnzyme
DB06176RomidepsinSmall Molecule128517-07-7Approved|InvestigationalEnzyme
DB06209PrasugrelSmall Molecule150322-43-3ApprovedEnzyme
DB06413ArmodafinilSmall Molecule112111-43-0Approved|InvestigationalEnzyme
DB06470clomethiazoleSmall MoleculeInvestigationalEnzyme
DB06595MidostaurinSmall Molecule120685-11-2Approved|InvestigationalEnzyme
DB06697ArtemetherSmall Molecule71963-77-4ApprovedEnzyme
DB06710MethyltestosteroneSmall Molecule58-18-4ApprovedEnzyme
DB06729SulfaphenazoleSmall Molecule526-08-9ApprovedEnzyme
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalEnzyme
DB06739SeratrodastSmall Molecule112665-43-7ApprovedEnzyme
DB06770Benzyl alcoholSmall Molecule100-51-6ApprovedEnzyme
DB08864RilpivirineSmall Molecule500287-72-9ApprovedEnzyme
DB08865CrizotinibSmall Molecule877399-52-5ApprovedEnzyme
DB08896RegorafenibSmall Molecule755037-03-7ApprovedEnzyme
DB08899EnzalutamideSmall Molecule915087-33-1ApprovedEnzyme
DB09054IdelalisibSmall Molecule870281-82-6ApprovedEnzyme
DB09068VortioxetineSmall Molecule508233-74-7Approved|InvestigationalEnzyme
DB09074OlaparibSmall Molecule763113-22-0ApprovedEnzyme
DB09238ManidipineSmall Molecule89226-50-6Approved|InvestigationalEnzyme
DB09280LumacaftorSmall Molecule936727-05-8ApprovedEnzyme
DB09570IxazomibSmall Molecule1072833-77-2Approved|InvestigationalEnzyme
DB11613VelpatasvirSmall Molecule1377049-84-7Approved|InvestigationalEnzyme
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalEnzyme
DB11642PitolisantSmall Molecule362665-56-3Approved|InvestigationalEnzyme
DB12070LetermovirSmall Molecule917389-32-3Approved|InvestigationalEnzyme
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalEnzyme
DB13941PiperaquineSmall Molecule4085-31-8Approved|InvestigationalEnzyme
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedEnzyme
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedEnzyme
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C4956571,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane"CYP2B6 protein results in increased chemical synthesis of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane"9733665
C4956571,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane"CYP2B6 protein results in increased hydroxylation of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane"12167570|9047321
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP2B6 mRNA"17690111
C0264861,2,5,6-dibenzanthracene"CYP2B6 protein results in increased metabolism of 1,2,5,6-dibenzanthracene"8638931
C0264861,2,5,6-dibenzanthracene"[CYP2B6 protein results in increased metabolism of 1,2,5,6-dibenzanthracene] which results in increased chemical synthesis of dibenzoanthracene-3,4-dihydrodiol"8638931
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]"15764585
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"androstan-3-ol inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]]"15764585
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA"23539296
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA"20361990
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]"17483497
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA]"23539296
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]"21424122
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Androstenols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B6 mRNA]"21424122
C0917651,4-dihydroxy-2-nonene"[CYP2B6 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene"21766881
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"CYP2B6 protein results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"CYP2B6 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"[CYP2B6 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene metabolite"29285606
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"[CYP2B6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C0353421,4-naphthoquinone"CYP2B6 protein results in increased abundance of 1,4-naphthoquinone"16243959
C1067461,5-benzothiazepine"1,5-benzothiazepine analog results in increased expression of CYP2B6 mRNA"21315811
C4780041-hydroxy-2,3,5-trimethoxyxanthone"CYP2B6 protein results in increased metabolism of 1-hydroxy-2,3,5-trimethoxyxanthone"24380714
C0293501-naphtholCYP2B6 protein results in increased abundance of 1-naphthol16243959
C0243361-phenylazo-2-naphtholCYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]17159775
C0243361-phenylazo-2-naphtholCYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol17159775
C4776942,2',4,4',5-brominated diphenyl ether"CYP2B6 protein results in increased metabolism of 2,2',4,4',5-brominated diphenyl ether"22738989
C5003362,2',4,4',5-pentachlorobiphenyl"CYP2B6 gene SNP affects the susceptibility to 2,2',4,4',5-pentachlorobiphenyl"25839716
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether results in increased activity of CYP3A4 protein] which results in increased expression of CYP2B6 mRNA"24218150
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA"24218150
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B6 mRNA"24218150
C5112952,2',4,4'-tetrabromodiphenyl ether"CYP2B6 protein results in increased chemical synthesis of 2,2',4,4'-tetrabromodiphenyl ether analog"23249762
C5112952,2',4,4'-tetrabromodiphenyl ether"CYP2B6 protein results in increased metabolism of 2,2',4,4'-tetrabromodiphenyl ether"23249762|2353700
C5726252,2',4,5'-tetrabromodiphenyl ether"CYP2B6 protein results in increased chemical synthesis of 2,2',4,5'-tetrabromodiphenyl ether analog"23249762
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of CYP2B6 mRNA"19135037
C0674112,2-dichloro-1,1,1-trifluoroethane"CYP2B6 protein results in increased metabolism of 2,2-dichloro-1,1,1-trifluoroethane"11684365
C0679402,3,3',4,4'-pentachlorobiphenyl"CYP2B6 gene SNP affects the susceptibility to 2,3,3',4,4'-pentachlorobiphenyl"25839716
C0700552,3',4,4',5-pentachlorobiphenyl"CYP2B6 gene SNP affects the susceptibility to 2,3',4,4',5-pentachlorobiphenyl"25839716
C0700552,3',4,4',5-pentachlorobiphenyl"CYP2B6 protein results in increased metabolism of 2,3',4,4',5-pentachlorobiphenyl"27208082
C492600(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate results in increased expression of CYP2B6 mRNA"19378387
C0005927672-(4'-methoxybenzenesulfonyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid amide"2-(4'-methoxybenzenesulfonyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid amide inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]"27387538
C0038982-anisidineCYP2B6 protein results in increased oxidation of 2-anisidine15828049
C5865422'-(glutathion-S-yl)-deschlorodiclofenac[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac24246759
C5403952-methyl-5-isopropenylcyclohex-2-enone oximeCYP2B6 protein results in increased metabolism of 2-methyl-5-isopropenylcyclohex-2-enone oxime19125687
C0284052-naphtholCYP2B6 protein results in increased abundance of 2-naphthol16243959
C0053282-nitroanisoleCYP2B6 protein results in increased metabolism of 2-nitroanisole15144223
C0053282-nitroanisoleCYP2B6 protein results in increased oxidation of 2-nitroanisole17159769|2121810
C0455732-nitrophenolCYP2B6 protein affects the chemical synthesis of 2-nitrophenol11409192
C0455732-nitrophenolCYP2B6 protein affects the chemical synthesis of 2-nitrophenol11409192
C0455732-nitrophenolCYP2B6 protein affects the chemical synthesis of 2-nitrophenol11409192
C5409042-oxo-clopidogrelCYP2B6 protein results in increased oxidation of 2-oxo-clopidogrel19812348
C4128352-phenyl-2-(1-piperidinyl)propane2-phenyl-2-(1-piperidinyl)propane results in decreased activity of CYP2B6 protein15155557|2133651
C0450222-propyl-4-pentenoic acidCYP2B6 protein results in increased chemical synthesis of 2-propyl-4-pentenoic acid16945988
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2B6 mRNA"19692669
C0168343,5-xylenol"CYP2B6 protein results in increased oxidation of 3,5-xylenol analog"27665777
C0168343,5-xylenol"[CYP2B6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog"27665777
C5716313-bromomethcathinoneCYP2B6 protein results in increased metabolism of 3-bromomethcathinone27320963
C5458804,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide"CYP2B6 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide"19697924
C0752054-bromo-2-chlorophenol[CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol23415833
C0275764-hydroxy-2-nonenal[CYP2B6 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid21766881
C0275764-hydroxy-2-nonenal"[CYP2B6 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene"21766881
C0275764-hydroxy-2-nonenalCYP2B6 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal21766881
C0917664-hydroxy-2-nonenoic acid[CYP2B6 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid21766881
C0123584-hydroxycyclophosphamideCYP2B6 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide24819615
C0554924-hydroxy-N-desmethyltamoxifenCYP2B6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen29285606
C0554924-hydroxy-N-desmethyltamoxifen[CYP2B6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen] which results in increased abundance of 4-hydroxy-N-desmethyltamoxifen metabolite29285606
C0912074-hydroxyvalproateCYP2B6 protein results in increased chemical synthesis of 4-hydroxyvalproate16945988
C0443904-(methylsulfinyl)phenolCYP2B6 protein results in increased abundance of 4-(methylsulfinyl)phenol analog27665777
C0443904-(methylsulfinyl)phenol"[CYP2B6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog"27665777
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCYP2B6 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone12920169
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCYP2B6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone10799646
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCYP2B6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone25221795
C0415944-nonylphenol4-nonylphenol results in increased expression of CYP2B6 mRNA17483497
C0415944-nonylphenol[4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA17483497
C0415944-nonylphenol4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]17483497
C0334205,6-dehydronorketamine"CYP2B6 protein results in increased chemical synthesis of 5,6-dehydronorketamine"23142468
C0409975-bromotryptamine5-bromotryptamine analog results in decreased activity of CYP2B6 protein26599973
C0409975-bromotryptamine[5-bromotryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C5291695-chlorotryptamine5-chlorotryptamine analog results in decreased activity of CYP2B6 protein26599973
C5291695-chlorotryptamine[5-chlorotryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C0511015-fluoro-alpha-methyltryptamine5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2B6 protein26599973
C0511015-fluoro-alpha-methyltryptamine[5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C0345365-fluorotryptamine5-fluorotryptamine analog results in decreased activity of CYP2B6 protein26599973
C0345365-fluorotryptamine[5-fluorotryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C1177155-hydroxydiclofenac[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac24246759
C0912085-hydroxyvalproateCYP2B6 protein results in increased chemical synthesis of 5-hydroxyvalproate16945988
C0336965-methoxy-N,N-diisopropyltryptamine"5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein"26599973
C0336965-methoxy-N,N-diisopropyltryptamine"[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion"26599973
C0275525-methyltryptamine5-methyltryptamine analog results in decreased activity of CYP2B6 protein26599973
C0275525-methyltryptamine[5-methyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C0005889585-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid results in decreased activity of CYP2B6 protein23631744
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA"18468591
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA"23539296
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein"19202563|2506980
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA"20361990
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6"22896671
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA"16608920|1833207
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein"21227907|2177846
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein]"25069801
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"25069801
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]"25069801
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]"25069801
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"24224465
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"28289823
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"GW 3965 inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"23732298
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21778469
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]"21778469
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"16608920
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"24224465
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR0B1 protein inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6]"22896671
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"25069801
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
C0662097-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine"7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine results in increased expression of CYP2B6 mRNA"21315811
C0560337-ethoxy-4-trifluoromethylcoumarinCYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin9241656
C0560337-ethoxy-4-trifluoromethylcoumarinCYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin12464242|2385098
C0560337-ethoxy-4-trifluoromethylcoumarin[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin23850985
C0560337-ethoxy-4-trifluoromethylcoumarinCYP2B6 protein results in increased oxidation of 7-ethoxy-4-trifluoromethylcoumarin21964418
C0560337-ethoxy-4-trifluoromethylcoumarinMephenytoin inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]9241656
C0560337-ethoxy-4-trifluoromethylcoumarinMethoxychlor inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]9241656
C0560337-ethoxy-4-trifluoromethylcoumarinOrphenadrine inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]9241656
C0560337-ethoxy-4-trifluoromethylcoumarinperfluorooctane sulfonic acid inhibits the reaction [CYP2B6 protein results in increased oxidation of 7-ethoxy-4-trifluoromethylcoumarin]21964418
C0560337-ethoxy-4-trifluoromethylcoumarinTranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]23850985
C0842367-hydroxy-4-trifluoromethylcoumarinCYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin9241656
C0842367-hydroxy-4-trifluoromethylcoumarin[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin23850985
C0842367-hydroxy-4-trifluoromethylcoumarinMephenytoin inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]9241656
C0842367-hydroxy-4-trifluoromethylcoumarinMethoxychlor inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]9241656
C0842367-hydroxy-4-trifluoromethylcoumarinOrphenadrine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]9241656
C0842367-hydroxy-4-trifluoromethylcoumarinTranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]23850985
C0366967-methyltryptamine7-methyltryptamine analog results in decreased activity of CYP2B6 protein26599973
C0366967-methyltryptamine[7-methyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C4210109-(4'-aminophenyl)-9H-pyrido(3,4-b)indole"CYP2B6 protein results in increased chemical synthesis of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole"15279827
D000082AcetaminophenAcetaminophen results in decreased expression of CYP2B6 mRNA29067470
C043377acetochlorCYP2B6 protein results in increased metabolism of acetochlor11133395
C016601afimoxifeneCYP2B6 protein results in increased metabolism of afimoxifene29285606
C016601afimoxifene[CYP2B6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite29285606
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYP2B6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP2B6 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYP2B6 mRNA21994236
C000188alachlorCYP2B6 protein results in decreased susceptibility to alachlor16277416
D000452AldrinAldrin results in increased expression of CYP2B6 protein15548381
C004471allyl isothiocyanate"allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein]"25069801
C004471allyl isothiocyanate"allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"25069801
C004471allyl isothiocyanate"allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]"25069801
C004471allyl isothiocyanate"allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]"25069801
C038491allyl sulfideallyl sulfide results in increased expression of CYP2B6 mRNA17353348
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CYP2B6 mRNA28522335
D000638AmiodaroneCYP2B6 protein results in decreased susceptibility to Amiodarone26477383
D000639AmitriptylineCYP2B6 protein results in increased metabolism of Amitriptyline27320963
C006566amitriptyline N-oxideCYP2B6 protein results in increased abundance of amitriptyline N-oxide27320963
D017311AmlodipineAmlodipine results in decreased activity of CYP2B6 protein10805063
D000661AmphetamineCYP2B6 protein affects the chemical synthesis of Amphetamine15294457
C003530androst-16-en-3-ol"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA"20361990
C003530androst-16-en-3-ol[Endosulfan inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA20361990
C000658androstan-3-ol"androstan-3-ol inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]]"15764585
C000658androstan-3-ol[4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA17483497
D000737Androstenols"Androstenols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B6 mRNA]"21424122
D000737AndrostenolsAndrostenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]21424122
C023650anilineCYP2B6 protein affects the metabolism of [norharman co-treated with aniline]15279827
D000841Anisomycin"[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA"23539296
D000841Anisomycin"Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA]"23539296
C094428AQ4NCYP2B6 protein results in increased metabolism of AQ4N15712360
D016718Arachidonic AcidCYP2B6 protein results in increased metabolism of Arachidonic Acid12675279
D001095Arachidonic AcidsCYP2B6 protein results in increased chemical synthesis of Arachidonic Acids metabolite12675279
C026987aroclor 1260aroclor 1260 results in increased expression of CYP2B6 mRNA24812009
D001140AroclorsAroclors results in increased expression of CYP2B6 protein29162470
C031327artemisinine[artemisinine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
C031327artemisinineartemisinine results in increased expression of CYP2B6 mRNA15761118|1833207
C031327artemisinineCYP2B6 protein affects the metabolism of artemisinine12920490
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of CYP2B6 mRNA15802384
D001280Atrazine[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2B6 mRNA22515965
D001280AtrazineAtrazine results in increased activity of CYP2B6 protein22310298
D001280AtrazineAtrazine results in increased expression of CYP2B6 mRNA22310298|2251596
D001280Atrazine[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to Atrazine16608219
D001280Atrazine[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]16608219
D001280Atrazine[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2B6 protein22515965
C423185avasimibeavasimibe results in increased expression of and results in increased activity of CYP2B6 protein15333513
C423185avasimibeavasimibe results in increased expression of CYP2B6 mRNA15333513
C087670azoxystrobinazoxystrobin results in increased expression of CYP2B6 protein29294346
C087670azoxystrobin[cyproconazole co-treated with azoxystrobin] results in increased expression of CYP2B6 protein29294346
C006680baicaleinbaicalein results in increased expression of CYP2B6 mRNA25625231
C096128benfuracarbbenfuracarb results in increased activity of CYP2B6 protein22310298
C096128benfuracarbbenfuracarb results in increased expression of CYP2B6 mRNA22310298
C061004benidipinebenidipine results in increased expression of CYP2B6 mRNA27732883
C061004benidipinebenidipine results in increased expression of CYP2B6 protein27732883
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased activity of CYP2B6 protein19497361|2225856
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of CYP2B6 mRNA19118567
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CYP2B6 mRNA20106945
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP2B6 mRNA"17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP2B6 mRNA15735009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CYP2B6 gene25435355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CYP2B6 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"CYP2B6 gene SNP affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide binds to ALB protein]"22521834
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"CYP2B6 gene SNP affects the susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"22521834
D001589BenzphetamineCYP2B6 protein results in increased metabolism of Benzphetamine12464242|1576988
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"24224465
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]24224465
C057754benzyloxyresorufinCYP2B6 protein results in increased metabolism of benzyloxyresorufin12464242|8819299
C057754benzyloxyresorufinProadifen inhibits the reaction [CYP2B6 protein results in increased metabolism of benzyloxyresorufin]8819299
C068337bergamottinbergamottin results in decreased activity of CYP2B6 protein15769884
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
D004958EstradiolEstradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D004958EstradiolEstradiol promotes the reaction [[ESR1 protein binds to CYP2B6 promoter] which results in increased expression of CYP2B6 mRNA]20079471|2007947
D004958EstradiolEstradiol promotes the reaction [[NCOA3 protein binds to CYP2B6 promoter] which results in increased expression of CYP2B6 mRNA]20079471|2007947
D004958EstradiolEstradiol results in increased expression of CYP2B6 mRNA20079471|2283738
D004958Estradiol"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]"21768169
D004958EstradiolNR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]21768169
D004958Estradiol"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
D004958Estradiol[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D001663BilirubinBilirubin results in increased expression of CYP2B6 mRNA15382119
D001663BilirubinIL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]15382119
C006780bisphenol Abisphenol A affects the expression of CYP2B6 mRNA24793377
C006780bisphenol Abisphenol A results in increased expression of CYP2B6 mRNA26196221
C006780bisphenol Abisphenol A results in decreased expression of CYP2B6 mRNA25181051
C086232bosentanbosentan results in increased expression of CYP2B6 mRNA18332078
D016642Bupropion"2-(4'-methoxybenzenesulfonyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid amide inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]"27387538
D016642Bupropion[5-bromotryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropion[5-chlorotryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropion[5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropion[5-fluorotryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropion"[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion"26599973
D016642Bupropion[5-methyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropion[7-methyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642BupropionCamphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642Bupropioncitral inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642BupropionClorgyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D016642Bupropioncyhalothrin inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
D016642BupropionCYP2B6 protein affects the metabolism of Bupropion15626586
D016642BupropionCYP2B6 protein results in increased hydrolysis of Bupropion18611395
D016642BupropionCYP2B6 protein results in increased hydroxylation of Bupropion22634058|2377798
D016642BupropionCYP2B6 protein results in increased metabolism of Bupropion15155557|1576988
D016642Bupropion[CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of hydroxybupropion25084468
D016642Bupropion[CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of radafaxine19135037
D016642Bupropiondecamethrin inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
D016642Bupropion[efavirenz results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropioneucalyptol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642BupropionFenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
D016642Bupropionfenvalerate inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
D016642Bupropiongeraniol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642Bupropion[indopan analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropion[indopan results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropionisoborneol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642BupropionMenthol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642Bupropion[Methoxydimethyltryptamines analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropion"[N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion"26599973
D016642Bupropion"[N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion"26599973
D016642BupropionPargyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D016642Bupropionperillaldehyde inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642BupropionPhenelzine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D016642BupropionSelegiline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D016642Bupropion[Sertraline results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642Bupropionsibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]23777987
D016642BupropionThiotepa inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D016642BupropionThiotepa inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]23777987
D016642BupropionTiclopidine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]23850985
D016642BupropionTranylcypromine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]28119166
D016642Bupropion[Tryptamines analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D016642BupropionCYP2B6 protein affects the metabolism of Bupropion12598790
C054409butachlorCYP2B6 protein results in increased metabolism of butachlor11133395
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of CYP2B6 mRNA18570159
D002164CamphorCamphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D002185CannabidiolCannabidiol results in decreased activity of CYP2B6 protein24667653
D002220Carbamazepine[Carbamazepine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D002220Carbamazepine[Carbamazepine results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA17041008
D002220CarbamazepineCarbamazepine results in increased expression of CYP2B6 mRNA17112801
D002220CarbamazepineCarbamazepine results in increased expression of CYP2B6 protein14977870
D012721CarbarylCarbaryl results in increased activity of CYP2B6 protein22310298
D012721CarbarylCarbaryl results in increased expression of CYP2B6 mRNA22310298
C006698carbendazimcarbendazim results in increased expression of CYP2B6 mRNA22310298
D002235CarbofuranCarbofuran results in increased activity of CYP2B6 protein22310298
D002235CarbofuranCarbofuran results in increased expression of CYP2B6 mRNA22310298
C035038carbosulfancarbosulfan results in increased activity of CYP2B6 protein22310298
C035038carbosulfancarbosulfan results in increased expression of CYP2B6 mRNA22310298
C035038carbosulfanCYP2B6 protein results in increased metabolism of carbosulfan20307514
C088453Celsior[Celsior co-treated with Phenobarbital] results in increased expression of CYP2B6 mRNA15448115
C088453CelsiorCelsior results in decreased expression of CYP2B6 mRNA15448115
C086276cerivastatincerivastatin results in increased expression of CYP2B6 mRNA15802384
D002706ChlordanChlordan results in increased expression of CYP2B6 protein15548381
D007631ChlordeconeChlordecone results in increased expression of CYP2B6 protein15548381
C057223chlorfluazuronchlorfluazuron results in increased activity of CYP2B6 protein22310298
C057223chlorfluazuronchlorfluazuron results in increased expression of CYP2B6 mRNA22310298
C013874chloroacetamideCYP2B6 protein results in increased metabolism of and results in decreased susceptibility to chloroacetamide15853388
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CYP2B6 mRNA17851650
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CYP2B6 protein17851650
D002746Chlorpromazine[Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D002746ChlorpromazineCYP2B6 protein results in decreased susceptibility to Chlorpromazine26477383
D004390Chlorpyrifos[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2B6 mRNA22515965
D004390Chlorpyrifos"Chlorpyrifos inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of N,N-diethyl-3-hydroxymethylbenzamide]"11854147
D004390ChlorpyrifosChlorpyrifos inhibits the reaction [CYP2B6 protein results in increased metabolism of DEET]11854147
D004390ChlorpyrifosChlorpyrifos results in decreased activity of CYP2B6 protein20183062|2231029
D004390ChlorpyrifosChlorpyrifos results in increased expression of CYP2B6 mRNA16190164|1675708
D004390ChlorpyrifosChlorpyrifos results in increased expression of CYP2B6 protein15548381
D004390ChlorpyrifosCYP2B6 protein affects the metabolism of Chlorpyrifos15557345|1707935
D004390ChlorpyrifosCYP2B6 protein results in decreased sulfation of and results in increased activity of Chlorpyrifos15764407
D004390ChlorpyrifosCYP2B6 protein results in decreased sulfation of Chlorpyrifos17079358
D004390ChlorpyrifosCYP2B6 protein results in increased activity of Chlorpyrifos22281205
D004390ChlorpyrifosCYP2B6 results in increased metabolism of Chlorpyrifos20709133
D004390Chlorpyrifos[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2B6 protein22515965
D004390ChlorpyrifosChlorpyrifos results in increased expression of CYP2B6 protein22515965
C007033chlortoluronCYP2B6 protein results in increased metabolism of and results in decreased susceptibility to chlortoluron15853388
C043561chrysinchrysin results in increased expression of CYP2B6 mRNA25625231
D002927CimetidineCimetidine results in decreased activity of CYP2B6 protein22733800
D002927CimetidineCimetidine results in decreased expression of CYP2B6 protein22733800
D002927Cimetidine[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein22733800
C007076citralcitral inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
C012255clobazamCYP2B6 protein results in increased metabolism of clobazam28243904
C012255clobazam[CYP2B6 protein results in increased metabolism of clobazam] which results in increased chemical synthesis of N-desmethylclobazam28243904
D002994ClofibrateClofibrate results in decreased expression of CYP2B6 mRNA19952500
C055162clopidogrelclopidogrel inhibits the reaction [CYP2B6 protein results in decreased methylation of Ketamine]23142468
C055162clopidogrelCYP2B6 protein results in increased oxidation of clopidogrel19812348
D003010ClorgylineClorgyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D003010ClorgylineClorgyline results in decreased activity of CYP2B6 protein25656918
D003022ClotrimazoleClotrimazole results in increased activity of CYP2B6 protein14977870
D003022ClotrimazoleClotrimazole results in increased expression of and results in increased activity of CYP2B6 protein12695351
D003022ClotrimazoleClotrimazole results in increased expression of CYP2B6 protein12571232|1497787
D003022ClotrimazoleDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]12695351
D003022ClotrimazoleNR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]12695351
D003022ClotrimazoleNR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]12695351
D009249NADP[Ethinyl Estradiol co-treated with NADP] results in decreased activity of CYP2B6 protein11805216|1648590
D009249NADP[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein25500267
D009249NADPMephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]25500267
D019327Copper SulfateCopper Sulfate results in increased expression of CYP2B6 mRNA19549813
D003367CotinineCYP2B6 protein results in increased chemical synthesis of Cotinine12488541
C007164cumene hydroperoxideCYP2B6 protein affects the oxidation of cumene hydroperoxide17478480
D003520CyclophosphamideCYP2B6 protein results in increased hydroxylation of Cyclophosphamide16546968
D003520CyclophosphamideCyclophosphamide results in decreased expression of and results in decreased activity of CYP2B6 protein12872138
D003520Cyclophosphamide[Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D003520CyclophosphamideCyclophosphamide results in increased expression of and results in increased activity of CYP2B6 protein24663500
D003520CyclophosphamideCyclophosphamide results in increased expression of CYP2B6 mRNA24663500
D003520CyclophosphamideCYP2B6 intron polymorphism affects the hydroxylation of Cyclophosphamide17502835
D003520CyclophosphamideCYP2B6 promoter polymorphism affects the hydroxylation of Cyclophosphamide17502835
D003520CyclophosphamideCYP2B6 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide15248218
D003520CyclophosphamideCYP2B6 protein results in increased hydroxylation of Cyclophosphamide12872138|1618326
D003520CyclophosphamideCYP2B6 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide25860621
D003520CyclophosphamideCYP2B6 protein results in increased metabolism of Cyclophosphamide15769884|1821224
D003520CyclophosphamideCYP2B6 protein results in increased susceptibility to Cyclophosphamide11389073|1249808
D003520CyclophosphamideCYP2B6 results in increased susceptibility to Cyclophosphamide9766669
D003520Cyclophosphamide[Doxorubicin co-treated with Cyclophosphamide] affects the expression of CYP2B6 mRNA16322899
D003520CyclophosphamideMonocrotophos promotes the reaction [Cyclophosphamide results in increased expression of and results in increased activity of CYP2B6 protein]24663500
D003520CyclophosphamideMonocrotophos promotes the reaction [Cyclophosphamide results in increased expression of CYP2B6 mRNA]24663500
D003520CyclophosphamidePOR promotes the reaction [CYP2B6 results in increased susceptibility to Cyclophosphamide]9766669
D003520CyclophosphamidePOR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to Cyclophosphamide]10919648
D003520CyclophosphamideCYP2B6 protein results in increased activity of Cyclophosphamide11723234
D003520CyclophosphamideCYP2B6 protein results in increased hydroxylation of and results in increased susceptibility to Cyclophosphamide15919850
D003520CyclophosphamideCYP2B6 results in increased metabolism of Cyclophosphamide12571232
D016572CyclosporineCyclosporine results in decreased expression of CYP2B6 mRNA20106945
C037304cyhalothrincyhalothrin inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
C037304cyhalothrincyhalothrin results in decreased activity of CYP2B6 protein22634058
C037304cyhalothrincyhalothrin results in increased activity of CYP2B6 protein22310298
C037304cyhalothrincyhalothrin results in increased expression of CYP2B6 mRNA22310298
C017160cypermethrincypermethrin results in increased activity of CYP2B6 protein22310298
C017160cypermethrincypermethrin results in increased expression of CYP2B6 mRNA22310298
C017160cypermethrincypermethrin results in increased expression of CYP2B6 protein15548381
C093628cyproconazole[cyproconazole co-treated with azoxystrobin] results in increased expression of CYP2B6 protein29294346
C093628cyproconazolecyproconazole results in increased expression of CYP2B6 mRNA28058446
C093628cyproconazolecyproconazole results in increased expression of CYP2B6 protein29294346
D003634DDTCYP2B6 gene SNP affects the reaction [DDT results in increased abundance of Dichlorodiphenyl Dichloroethylene]27839851
D003634DDT[CYP2B6 gene SNP affects the susceptibility to DDT] which affects the abundance of Dichlorodiphenyl Dichloroethylene27839851
D003634DDTDDT results in increased expression of CYP2B6 mRNA20686338
D003634DDTDDT results in increased expression of CYP2B6 protein15548381
C017180decamethrindecamethrin inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
C017180decamethrindecamethrin results in decreased activity of CYP2B6 protein22634058
C017180decamethrindecamethrin results in increased activity of CYP2B6 protein22310298
C017180decamethrindecamethrin results in increased expression of CYP2B6 mRNA19326768|2231029
C064445dechloroethylcyclophosphamideCYP2B6 protein affects the chemical synthesis of dechloroethylcyclophosphamide15875221
C038007dechloroethylifosfamideCYP2B6 protein affects the chemical synthesis of dechloroethylifosfamide15875221
D003671DEETChlorpyrifos inhibits the reaction [CYP2B6 protein results in increased metabolism of DEET]11854147
D003671DEETCYP2B6 protein results in increased metabolism of DEET11854147
D003671DEETDEET results in increased expression of CYP2B6 mRNA19326769|2709163
D003671DEET[fipronil co-treated with DEET] results in increased expression of CYP2B6 mRNA27091632
C052300deltanitdeltanit results in increased activity of CYP2B6 protein22310298
C052300deltanitdeltanit results in increased expression of CYP2B6 mRNA22310298
D003840Deoxycholic AcidDeoxycholic Acid metabolite results in increased expression of CYP2B6 mRNA27871908
D003907DexamethasoneDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]12695351
D003907DexamethasoneDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]]12695351
D003907DexamethasoneDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]12695351
D003907DexamethasoneDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]]12695351
D003907DexamethasoneDexamethasone promotes the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]12695351
D003907DexamethasoneDexamethasone promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]12695351
D003907DexamethasoneDexamethasone results in increased expression of and results in increased activity of CYP2B6 protein15802389
D003907DexamethasoneDexamethasone results in increased expression of CYP2B6 mRNA15802389|1911856
D003907DexamethasoneDexamethasone results in increased expression of CYP2B6 protein15548381
D003907DexamethasoneNR3C1 protein promotes the reaction [NR1I3 protein affects the reaction [[Dexamethasone co-treated with Phenobarbital] results in increased expression of CYP2B6 mRNA]]12695351
C032201dexamethasone 21-tributylacetatedexamethasone 21-tributylacetate results in increased expression of CYP2B6 protein14977870
D036381DiarylheptanoidsDiarylheptanoids results in decreased activity of CYP2B6 protein23850985
D036381DiarylheptanoidsDiarylheptanoids results in increased expression of CYP2B6 mRNA23850985
D003976DiazinonCYP2B6 protein affects the metabolism of Diazinon15557345|1576440
D003976DiazinonCYP2B6 protein results in decreased sulfation of and results in increased activity of Diazinon15764407
C018912dibenzoanthracene-3,4-dihydrodiol"[CYP2B6 protein results in increased metabolism of 1,2,5,6-dibenzanthracene] which results in increased chemical synthesis of dibenzoanthracene-3,4-dihydrodiol"8638931
D003632DichlorodiphenyldichloroethaneDichlorodiphenyldichloroethane results in increased expression of CYP2B6 mRNA20686338
D003633Dichlorodiphenyl DichloroethyleneCYP2B6 gene SNP affects the reaction [DDT results in increased abundance of Dichlorodiphenyl Dichloroethylene]27839851
D003633Dichlorodiphenyl Dichloroethylene[CYP2B6 gene SNP affects the susceptibility to DDT] which affects the abundance of Dichlorodiphenyl Dichloroethylene27839851
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CYP2B6 mRNA20686338
D004026DieldrinDieldrin results in increased expression of CYP2B6 protein15548381
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CYP2B6 protein21227907
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CYP2B6 mRNA21924250
C012125diisononyl phthalatediisononyl phthalate results in increased expression of CYP2B6 protein21227907
C012621dimemorfanCYP2B6 protein results in increased oxidation of dimemorfan19593786
D004237DiuronDiuron results in increased expression of CYP2B6 mRNA22310298
D004294DomperidoneCYP2B6 protein results in increased hydroxylation of Domperidone15327587
D004317Doxorubicin[Doxorubicin co-treated with Cyclophosphamide] affects the expression of CYP2B6 mRNA16322899
C098320efavirenzCYP2B6 gene polymorphism affects the metabolism of efavirenz17559344
C098320efavirenzCYP2B6 protein affects the metabolism of efavirenz15622315
C098320efavirenzCYP2B6 protein results in increased metabolism of efavirenz15769884|1755934
C098320efavirenzefavirenz results in decreased activity of CYP2B6 protein26599973
C098320efavirenz[efavirenz results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C098320efavirenz[efavirenz results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
C098320efavirenz[efavirenz results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA17041008
C098320efavirenzCYP2B6 protein results in increased metabolism of efavirenz16625385
C098320efavirenzefavirenz results in decreased activity of CYP2B6 protein12598790
D004726Endosulfan[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2B6 mRNA22515965
D004726EndosulfanCYP2B6 protein affects the metabolism of Endosulfan16581944|1685505
D004726Endosulfan[Endosulfan co-treated with Methoxychlor] results in decreased activity of CYP2B6 protein24832206
D004726Endosulfan[Endosulfan co-treated with NR1I2 protein] results in increased expression of CYP2B6 mRNA20361990
D004726EndosulfanEndosulfan results in increased activity of CYP2B6 protein24832206
D004726Endosulfan[Endosulfan results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA20361990
D004726EndosulfanEndosulfan results in increased expression of CYP2B6 mRNA22515965|2483220
D004726EndosulfanEndosulfan results in increased expression of CYP2B6 protein15548381|2036199
D004726EndosulfanESR1 mRNA promotes the reaction [Endosulfan results in increased expression of CYP2B6 mRNA]28673560
D004726EndosulfanTiclopidine inhibits the reaction [CYP2B6 protein affects the metabolism of Endosulfan]16855053
D004726Endosulfan[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP2B6 protein22515965
D004726Endosulfan[Endosulfan inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA20361990
D004726EndosulfanEndosulfan results in increased activity of CYP2B6 protein17936932
C544689endosulfan sulfate[endosulfan sulfate co-treated with NR1I2 protein] results in increased expression of CYP2B6 mRNA20361990
D004732EndrinEndrin results in increased expression of CYP2B6 protein15548381
C109476epoxiconazole[fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP2B6 mRNA29294346
C109476epoxiconazole[fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP2B6 protein29294346
C091891epsilon-viniferinepsilon-viniferin results in decreased activity of CYP2B6 protein12818727
D000431Ethanol[Nicotine co-treated with Ethanol] results in increased expression of CYP2B6 protein22935730
D004997Ethinyl EstradiolCYP2B6 protein affects the metabolism of Ethinyl Estradiol16485904
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with NADP] results in decreased activity of CYP2B6 protein11805216|1648590
C000611514ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate"ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"28289823
C000611514ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate"ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in increased expression of CYP2B6 mRNA"28289823
C000611514ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate"NR1I2 mRNA promotes the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in increased expression of CYP2B6 mRNA]"28289823
C010087eucalyptoleucalyptol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D015736FelodipineFelodipine results in increased expression of CYP2B6 mRNA27732883
D015736FelodipineFelodipine results in increased expression of CYP2B6 protein27732883
D005278FenitrothionFenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
D005278FenitrothionFenitrothion results in decreased activity of CYP2B6 protein20183062|2231029
D005278FenitrothionFenitrothion results in increased expression of CYP2B6 mRNA22310298
C026013fenproporexCYP2B6 protein results in decreased alkylation of fenproporex15294457
C017690fenvaleratefenvalerate inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]22634058
C017690fenvaleratefenvalerate results in decreased activity of CYP2B6 protein22634058
C017690fenvaleratefenvalerate results in increased activity of CYP2B6 protein22310298
C017690fenvaleratefenvalerate results in increased expression of CYP2B6 mRNA22310298
C017690fenvaleratefenvalerate results in increased expression of CYP2B6 protein15548381
C035874FG 7142FG 7142 results in increased expression of CYP2B6 mRNA21315811
D005363FicusinCAT protein inhibits the reaction [Ficusin results in decreased activity of CYP2B6 protein]26335194
D005363FicusinFicusin results in decreased activity of CYP2B6 protein26335194
D005363FicusinGlutathione inhibits the reaction [Ficusin results in decreased activity of CYP2B6 protein]26335194
D005363FicusinTiclopidine inhibits the reaction [Ficusin results in decreased activity of CYP2B6 protein]26335194
C082360fipronil[fipronil co-treated with DEET] results in increased expression of CYP2B6 mRNA27091632
C082360fipronilfipronil results in increased expression of CYP2B6 mRNA17084830|2709163
D005419FlavonoidsFlavonoids results in decreased expression of CYP2B6 mRNA18035473
C065180fluvastatinfluvastatin results in increased expression of CYP2B6 mRNA15802384
C000591719fluxapyroxad[fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP2B6 mRNA29294346
C000591719fluxapyroxad[fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP2B6 protein29294346
C000591719fluxapyroxadfluxapyroxad results in increased expression of CYP2B6 mRNA29294346
C000591719fluxapyroxadfluxapyroxad results in increased expression of CYP2B6 protein29294346
C037032galangingalangin results in increased expression of CYP2B6 mRNA25625231
C007836geraniolgeraniol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
C048393germacronegermacrone results in decreased activity of CYP2B6 protein23850985
C048393germacronegermacrone results in increased expression of CYP2B6 mRNA23850985
C063170Ginkgo biloba extractGinkgo biloba extract results in increased expression of CYP2B6 mRNA19034627
C477042ginkgolide Aginkgolide A results in increased expression of CYP2B6 mRNA19034627
C045856ginkgolide Bginkgolide B results in increased expression of CYP2B6 mRNA19034627
D005978Glutathione[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac24246759
D005978Glutathione[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac24246759
D005978GlutathioneGlutathione inhibits the reaction [Ficusin results in decreased activity of CYP2B6 protein]26335194
C473027GW 3965"GW 3965 inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"23732298
C473027GW 3965GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]23732298
D006221HalothaneCYP2B6 protein results in increased metabolism of Halothane11684365
D006540Herbicides[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to Herbicides16608219
C058039hexafluoronhexafluoron results in increased activity of CYP2B6 protein22310298
C058039hexafluoronhexafluoron results in increased expression of CYP2B6 mRNA22310298
C580748hydroxybupropionCYP2B6 protein results in increased chemical synthesis of hydroxybupropion23850985
C580748hydroxybupropion[CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of hydroxybupropion25084468
C001654hyperforinhyperforin results in increased expression of CYP2B6 mRNA24259679
D007069IfosfamideCYP2B6 protein affects the metabolism of Ifosfamide15875221
D007069IfosfamideCYP2B6 results in increased susceptibility to Ifosfamide9766669
D007069IfosfamidePOR promotes the reaction [CYP2B6 results in increased susceptibility to Ifosfamide]9766669
D007069IfosfamideCYP2B6 results in increased metabolism of Ifosfamide12571232
D007093Imidazoles"Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21778469
D007093Imidazoles"Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]"21778469
C002921imipramine N-oxideCYP2B6 protein results in increased abundance of imipramine N-oxide27320963
D007213IndomethacinIndomethacin results in decreased expression of CYP2B6 mRNA16771604
C015293indopanindopan analog results in decreased activity of CYP2B6 protein26599973
C015293indopan[indopan analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C015293indopanindopan results in decreased activity of CYP2B6 protein26599973
C015293indopan[indopan results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C022871isoborneolisoborneol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
C055542isoimperatorinCYP2B6 protein results in increased oxidation of isoimperatorin25500267
C055542isoimperatorin[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein25500267
C055542isoimperatorinMephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]25500267
C018326isomalathionisomalathion results in increased expression of CYP2B6 mRNA24333466
C018326isomalathionMalathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA]24333466
C028904isoproturonisoproturon results in increased activity of CYP2B6 protein22310298
C028904isoproturonisoproturon results in increased expression of CYP2B6 mRNA22310298
D007555IsoxazolesIsoxazoles analog affects the activity of CYP2B6 protein21924250
D007555IsoxazolesIsoxazoles analog results in increased expression of CYP2B6 mRNA21924250
D017275IsradipineIsradipine results in increased expression of CYP2B6 mRNA27732883
D017275IsradipineIsradipine results in increased expression of CYP2B6 protein27732883
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CYP2B6 mRNA26752646
D007649Ketamineclopidogrel inhibits the reaction [CYP2B6 protein results in decreased methylation of Ketamine]23142468
D007649KetamineCYP2B6 protein results in decreased methylation of Ketamine23142468
D007654Ketoconazole"Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"16608920
D007654KetoconazoleKetoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]16608920
D007654KetoconazoleKetoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]16608920|1743810
D007654KetoconazoleKetoconazole results in decreased activity of CYP2B6 protein14709627
C067713lactacystin"lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"24224465
C067713lactacystinlactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]24224465
C047781lamotrigineCYP2B6 protein results in increased glutathionylation of lamotrigine19961160
C052901lemongrass oillemongrass oil affects the expression of CYP2B6 mRNA25976427
C011896lephetamineCYP2B6 protein results in decreased alkylation of lephetamine26276083
D001556LindaneLindane results in increased expression of CYP2B6 mRNA20035023
D001556LindaneLindane results in increased expression of CYP2B6 protein15548381
D008294MalathionCYP2B6 protein affects the metabolism of Malathion15557345
D008294MalathionMalathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA]24333466
D008294MalathionMalathion results in decreased activity of CYP2B6 protein22310298
D008294MalathionMalathion results in increased expression of CYP2B6 mRNA22310298
C425686mefenacetCYP2B6 protein results in increased metabolism of and results in decreased susceptibility to mefenacet15853388
D008610MentholMenthol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D008617MephenytoinCYP2B6 protein results in increased hydroxylation of Mephenytoin12637241
D008617MephenytoinCYP2B6 protein results in decreased methylation of Mephenytoin12433797
D008617MephenytoinCYP2B6 protein results in increased metabolism of Mephenytoin12464242
D008617MephenytoinMephenytoin inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]9241656
D008617MephenytoinMephenytoin inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]9241656
D008617MephenytoinMephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]25500267
D008617MephenytoinMephenytoin results in decreased activity of CYP2B6 protein9241656
C050699mepirodipinemepirodipine results in decreased activity of CYP2B6 protein10805063
D008714MethiocarbCYP2B6 protein results in increased metabolism of Methiocarb27665777
D008714Methiocarb[CYP2B6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide27665777
C097911methiocarb sulfoxideCYP2B6 protein results in increased abundance of methiocarb sulfoxide27665777
C097911methiocarb sulfoxide[CYP2B6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide27665777
D003915DextromethorphanCYP2B6 protein results in increased metabolism of Dextromethorphan12637241
D008731MethoxychlorCYP2B6 protein results in decreased methylation of Methoxychlor12167570|1243379
D008731MethoxychlorCYP2B6 protein results in increased hydroxylation of Methoxychlor10101147|7895613
D008731MethoxychlorCYP2B6 protein results in increased metabolism of Methoxychlor12464242
D008731Methoxychlor[Endosulfan co-treated with Methoxychlor] results in decreased activity of CYP2B6 protein24832206
D008731MethoxychlorMethoxychlor inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]9241656
D008731MethoxychlorMethoxychlor inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]9241656
D008731MethoxychlorMethoxychlor results in decreased activity of CYP2B6 protein9241656
D008731MethoxychlorMethoxychlor results in increased activity of CYP2B6 protein24832206
D008731MethoxychlorMethoxychlor results in increased expression of CYP2B6 mRNA21924250|2483220
D008731MethoxychlorMethoxychlor results in increased expression of CYP2B6 protein15548381
D008732MethoxydimethyltryptaminesMethoxydimethyltryptamines analog results in decreased activity of CYP2B6 protein26599973
D008732Methoxydimethyltryptamines[Methoxydimethyltryptamines analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
D008733MethoxyfluraneCYP2B6 protein results in increased metabolism of Methoxyflurane7879937
D018817N-Methyl-3,4-methylenedioxyamphetamine"CYP2B6 affects the metabolism of N-Methyl-3,4-methylenedioxyamphetamine"21871945
C051786metolachlor[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to metolachlor16608219
C051786metolachlor[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]16608219
C051786metolachlorCYP2B6 protein results in increased degradation of and results in decreased susceptibility to metolachlor16277416
C051786metolachlorCYP2B6 protein results in increased metabolism of and results in decreased susceptibility to metolachlor15853388
C051786metolachlorCYP2B6 protein results in increased metabolism of metolachlor11133395
D015735Mifepristone[Mifepristone results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D008999Monocrotophos[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein22733800
D008999MonocrotophosMonocrotophos promotes the reaction [Cyclophosphamide results in increased expression of and results in increased activity of CYP2B6 protein]24663500
D008999MonocrotophosMonocrotophos promotes the reaction [Cyclophosphamide results in increased expression of CYP2B6 mRNA]24663500
D008999MonocrotophosMonocrotophos results in increased activity of CYP2B6 protein22733800
D008999MonocrotophosMonocrotophos results in increased expression of CYP2B6 mRNA22733800|2466350
D008999MonocrotophosMonocrotophos results in increased expression of CYP2B6 protein22733800
D008999Monocrotophos[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein22733800
D008999Monocrotophos[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA22733800
D008999Monocrotophos[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein22733800
D016293MoricizineMoricizine results in increased expression of CYP2B6 mRNA18332078
C104820N-(3-(aminomethyl)benzyl)acetamidineN-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]18206661
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CYP2B6 mRNA20551477
C024581N-desmethylclobazamCYP2B6 protein results in increased chemical synthesis of N-desmethylclobazam28243904
C024581N-desmethylclobazam[CYP2B6 protein results in increased metabolism of clobazam] which results in increased chemical synthesis of N-desmethylclobazam28243904
D019888NelfinavirNelfinavir results in decreased activity of CYP2B6 protein12598790
C000598690N-ethyl-1,2-diphenylethylamine"CYP2B6 protein results in decreased alkylation of N-ethyl-1,2-diphenylethylamine"26276083
D019829Nevirapine[Nevirapine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D019829Nevirapine[Nevirapine results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA17041008
C026385n-hexaneCYP2B6 protein results in increased hydroxylation of n-hexane16484137
D009538Nicotine[Nicotine co-treated with Ethanol] results in increased expression of CYP2B6 protein22935730
D009538NicotineNicotine results in increased expression of CYP2B6 protein22935730
D009538NicotineCYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine]18004205
D009538NicotineCYP2B6 protein results in increased metabolism of Nicotine12488541
C012655nimesulideCYP2B6 protein results in increased glutathionylation of nimesulide26524229
C000598691N-isopropyl-1,2-diphenylethylamine"CYP2B6 protein results in decreased alkylation of N-isopropyl-1,2-diphenylethylamine"26276083
C578955N,N-diallyl-5-methoxytryptamine"N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2B6 protein"26599973
C578955N,N-diallyl-5-methoxytryptamine"[N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion"26599973
C574385N,N-didesmethyl-4-hydroxytamoxifen"CYP2B6 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen"29285606
C574385N,N-didesmethyl-4-hydroxytamoxifen"[CYP2B6 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen] which results in increased abundance of N,N-didesmethyl-4-hydroxytamoxifen"29285606
C454677N,N-diethyl-3-hydroxymethylbenzamide"Chlorpyrifos inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of N,N-diethyl-3-hydroxymethylbenzamide]"11854147
C454677N,N-diethyl-3-hydroxymethylbenzamide"CYP2B6 protein results in increased chemical synthesis of N,N-diethyl-3-hydroxymethylbenzamide"11854147
C033695N,N-diisopropyltryptamine"N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein"26599973
C033695N,N-diisopropyltryptamine"[N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion"26599973
C081306N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide"N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide results in increased expression of CYP2B6 mRNA"21315811
C013161N-nitroso(di-n-propyl)amineCYP2B6 protein affects the metabolism of N-nitroso(di-n-propyl)amine10910959
C093285NOC 18NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]18206661
C001870nonachlornonachlor results in increased expression of CYP2B6 protein15548381
C025256nonylphenolCYP2B6 results in increased metabolism of nonylphenol9817083
C008677norflurazone[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone16608219
C008677norflurazone[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]16608219
C008677norflurazoneCYP2B6 protein results in increased metabolism of and results in decreased susceptibility to norflurazone15853388
C010262norharmanCYP2B6 protein affects the metabolism of [norharman co-treated with aniline]15279827
C033419norketamineCYP2B6 protein results in increased chemical synthesis of norketamine23142468
C025589ochratoxin Aochratoxin A results in decreased expression of CYP2B6 mRNA26505656
C025589ochratoxin Aochratoxin A results in increased expression of CYP2B6 mRNA21834667|2650565
D019301Oleic Acid[Oleic Acid co-treated with rosiglitazone] results in increased expression of CYP2B6 mRNA24534255
D019301Oleic Acid[Oleic Acid co-treated with troglitazone] results in increased expression of CYP2B6 mRNA24534255
C026209oltiprazoltipraz results in decreased activity of CYP2B6 protein19833192
C026209oltiprazoltipraz results in increased expression of CYP2B6 mRNA19833192
C026209oltiprazoltipraz results in increased expression of CYP2B6 protein19833192
D009853OmeprazoleOmeprazole results in increased activity of CYP2B6 protein19118567
D009853OmeprazoleOmeprazole results in increased expression of CYP2B6 mRNA17954527|1911856
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"CYP2B6 protein polymorphism affects the chemical synthesis of O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"22281205
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"CYP2B6 protein results in increased chemical synthesis of O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"22281205
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"CYP2B6 results in increased chemical synthesis of O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"20709133
C016340o,p'-DDT"o,p'-DDT results in increased expression of CYP2B6 mRNA"21924250
C016340o,p'-DDT"o,p'-DDT results in increased expression of CYP2B6 protein"15548381
D009966OrphenadrineOrphenadrine inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]9241656
D009966OrphenadrineOrphenadrine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]9241656
D009966OrphenadrineOrphenadrine results in decreased activity of CYP2B6 protein12464242|1530620
D008939MitotaneCYP2B6 gene polymorphism affects the abundance of Mitotane23524664
D008939MitotaneCYP2B6 protein affects the abundance of Mitotane23524664
D010126OzoneOzone results in increased expression of CYP2B6 mRNA24336422
D010278ParathionCYP2B6 protein affects the metabolism of Parathion15557345|1707935
D010278ParathionCYP2B6 protein results in decreased sulfation of Parathion17079358
D010278ParathionParathion results in increased expression of CYP2B6 mRNA26196221
D010293PargylinePargyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D010293PargylinePargyline results in decreased activity of CYP2B6 protein25656918
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in decreased expression of CYP2B6 mRNA17715259
D052638Particulate MatterParticulate Matter results in increased expression of CYP2B6 mRNA24769257
C030856pendimethalinCYP2B6 protein results in increased metabolism of and results in decreased susceptibility to pendimethalin15853388
C517827pentabrominated diphenyl ether 100CYP2B6 protein results in increased oxidation of pentabrominated diphenyl ether 10025629761
C517827pentabrominated diphenyl ether 100[CYP2B6 protein results in increased oxidation of pentabrominated diphenyl ether 100] which results in increased chemical synthesis of pentabrominated diphenyl ether 100 metabolite25629761
D010416PentachlorophenolPentachlorophenol results in increased expression of CYP2B6 protein15548381
C108042perfluorobutaneperfluorobutane results in increased expression of CYP2B6 mRNA23567314
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of CYP2B6 mRNA23567314
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of CYP2B6 mRNA23567314
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of CYP2B6 mRNA23567314
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid results in increased expression of CYP2B6 mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of CYP2B6 mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid inhibits the reaction [CYP2B6 protein results in increased oxidation of 7-ethoxy-4-trifluoromethylcoumarin]21964418
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYP2B6 mRNA21723365|2356731
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP2B6 mRNA23567314|2715376
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP2B6 mRNA17681415
C033342perillaldehydeperillaldehyde inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D026023PermethrinPermethrin affects the activity of CYP2B6 protein21924250
D026023PermethrinPermethrin results in increased expression of CYP2B6 mRNA19326768
D010622PhencyclidineCYP2B6 protein affects the metabolism of Phencyclidine analog16782764
D010622PhencyclidineCYP2B6 protein affects the oxidation of Phencyclidine16782764
D010622PhencyclidinePhencyclidine analog results in decreased activity of CYP2B6 protein16782764
D010622PhencyclidinePhencyclidine results in decreased activity of CYP2B6 protein16782764
D010624PhenelzinePhenelzine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D010624PhenelzinePhenelzine results in decreased activity of CYP2B6 protein25656918
D010634PhenobarbitalPhenobarbital results in increased expression of CYP2B6 protein19952500
D010634PhenobarbitalPhenobarbital results in increased expression of and results in increased activity of CYP2B6 protein12488541
D010634PhenobarbitalPhenobarbital results in increased expression of CYP2B6 mRNA22935730
D010634Phenobarbitalbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]24224465
D010634Phenobarbital[Celsior co-treated with Phenobarbital] results in increased expression of CYP2B6 mRNA15448115
D010634PhenobarbitalDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]]12695351
D010634PhenobarbitalDexamethasone promotes the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]12695351
D010634PhenobarbitalEstradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D010634PhenobarbitalKetoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]16608920
D010634Phenobarbitallactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]24224465
D010634PhenobarbitalNR1I2 protein affects the reaction [Phenobarbital results in increased expression of and results in increased activity of CYP2B6 protein]12695351
D010634PhenobarbitalNR1I2 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]12695351
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]21768169
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]21768169
D010634PhenobarbitalNR3C1 protein promotes the reaction [NR1I3 protein affects the reaction [[Dexamethasone co-treated with Phenobarbital] results in increased expression of CYP2B6 mRNA]]12695351
D010634PhenobarbitalPhenobarbital affects the localization of CYP2B6 protein24878338
D010634PhenobarbitalPhenobarbital results in increased activity of CYP2B6 protein14977870|1911856
D010634Phenobarbital[Phenobarbital results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D010634Phenobarbital[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA17041008
D010634PhenobarbitalPhenobarbital results in increased expression of and results in increased activity of CYP2B6 protein12695351|1580238
D010634PhenobarbitalPhenobarbital results in increased expression of CYP2B6 mRNA15629111|1580238
D010634PhenobarbitalPhenobarbital results in increased expression of CYP2B6 protein12571232|1497787
D010634Phenobarbital[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D010634PhenobarbitalProgesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D010634PhenobarbitalPhenobarbital results in increased expression of CYP2B6 mRNA12571232
C033457phenobarbital quinidineIL1B protein inhibits the reaction [phenobarbital quinidine results in increased expression of CYP2B6 mRNA]15382119
C033457phenobarbital quinidinephenobarbital quinidine affects the expression of CYP2B615849716
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of CYP2B6 mRNA15382119
C008838phenthoatephenthoate results in decreased activity of CYP2B6 protein22310298
C008838phenthoatephenthoate results in increased expression of CYP2B6 mRNA22310298
D010672PhenytoinDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]12695351
D010672PhenytoinN-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]18206661
D010672PhenytoinNOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]18206661
D010672PhenytoinNR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]12695351
D010672PhenytoinNR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]12695351
D010672PhenytoinNR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]15123723
D010672PhenytoinPhenytoin results in increased activity of CYP2B6 protein14977870
D010672Phenytoin[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D010672PhenytoinPhenytoin results in increased expression of and results in increased activity of CYP2B6 protein12695351
D010672PhenytoinPhenytoin results in increased expression of CYP2B6 mRNA15123723|1795452
D010672PhenytoinPhenytoin results in increased expression of CYP2B6 protein12571232|1497787
D010672Phenytoinpimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]18206661
D010695PhlorhizinPhlorhizin results in decreased expression of CYP2B6 mRNA22538082
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in decreased expression of CYP2B6 mRNA17715259
C087566piclamilastCYP2B6 protein results in increased metabolism of piclamilast12464242
C004479pimagedinepimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]18206661
C060836pioglitazonepioglitazone results in increased expression of CYP2B6 protein12642470
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP2B6 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CYP2B6 mRNA27551952
C037850PK 11195PK 11195 results in increased expression of CYP2B6 mRNA21315811
D010936Plant ExtractsPlant Extracts results in decreased activity of CYP2B6 protein20828605|2385098
D010936Plant ExtractsPlant Extracts results in increased expression of CYP2B6 mRNA23850985|2444630
D028321Plant PreparationsPlant Preparations results in decreased expression of CYP2B6 mRNA26530625
D011078Polychlorinated BiphenylsCYP2B6 gene SNP affects the susceptibility to Polychlorinated Biphenyls25839716
D011078Polychlorinated BiphenylsCYP2B6 protein affects the metabolism of Polychlorinated Biphenyls25839716
D011319Primaquine[CYP2B6 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine19616568
D011319PrimaquineCYP2B6 protein results in increased metabolism of Primaquine19616568
D011335ProadifenProadifen inhibits the reaction [CYP2B6 protein results in increased metabolism of benzyloxyresorufin]8819299
C045362prochlorazprochloraz results in increased expression of CYP2B6 mRNA28058446
C024273profenofosCYP2B6 protein results in increased metabolism of profenofos23415833
C024273profenofos[CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol23415833
C024273profenofosprofenofos results in decreased activity of CYP2B6 protein22310298
C024273profenofosprofenofos results in increased expression of CYP2B6 mRNA22310298
D011374Progesterone"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]"21768169
D011374ProgesteroneNR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]21768169
D011374Progesterone"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
D011374Progesterone[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]"21768169
D011374ProgesteroneProgesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]21768169
D011374ProgesteroneProgesterone results in increased expression of CYP2B6 mRNA22837389
D015742PropofolCYP2B6 protein results in increased metabolism of Propofol15769884
C030984pyrene[pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA26160115
C030984pyrenepyrene results in increased expression of CYP2B6 mRNA26160115
D011722PyrethrinsPyrethrins results in increased expression of CYP2B6 mRNA18022748
C496215radafaxineCYP2B6 protein results in increased chemical synthesis of radafaxine15155557
C496215radafaxine[CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of radafaxine19135037
D012110Reserpine[Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
D012293RifampinDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]]12695351
D012293RifampinDexamethasone promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]12695351
D012293RifampinGW 3965 inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]23732298
D012293RifampinKetoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]16608920|1743810
D012293RifampinNR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]25313206|2828982
D012293RifampinNR1I2 protein affects the reaction [Rifampin results in increased expression of and results in increased activity of CYP2B6 protein]12695351
D012293RifampinNR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]12695351
D012293Rifampin[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein22733800
D012293Rifampin[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA22733800
D012293Rifampin[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein22733800
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2B6 mRNA20361990
D012293RifampinRifampin results in increased activity of CYP2B6 protein14977870|1911856
D012293Rifampin[Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP2B6 mRNA17041008
D012293RifampinRifampin results in increased expression of and results in increased activity of CYP2B6 protein12695351|1470962
D012293RifampinRifampin results in increased expression of CYP2B6 mRNA12040753|1257123
D012293RifampinRifampin results in increased expression of CYP2B6 protein12571232|1497787
D019438RitonavirRitonavir results in increased activity of CYP2B6 protein26626330
D019438RitonavirRitonavir results in increased expression of CYP2B6 protein14977870
D019438RitonavirRitonavir results in decreased activity of CYP2B6 protein12598790
C057006Ro 21-5104NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP2B6 mRNA]25313206
C057006Ro 21-5104Ro 21-5104 results in increased expression of CYP2B6 mRNA25313206
C057006Ro 21-5104Ro 21-5104 results in increased expression of CYP2B6 protein25313206
C087123romidepsinCYP2B6 protein affects the metabolism of romidepsin15635176
C089730rosiglitazone[Oleic Acid co-treated with rosiglitazone] results in increased expression of CYP2B6 mRNA24534255
C089730rosiglitazonerosiglitazone results in increased expression of CYP2B6 protein12642470
D015575RoxithromycinRoxithromycin results in decreased activity of CYP2B6 protein17164692
D012642SelegilineSelegiline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]25656918
D012642SelegilineSelegiline results in decreased activity of CYP2B6 protein25656918
C009237senecioninesenecionine results in increased expression of CYP2B6 mRNA26100227
D020280SertralineCYP2B6 protein results in decreased methylation of and results in increased metabolism of Sertraline15547048
D020280SertralineSertraline results in decreased activity of CYP2B6 protein26599973
D020280Sertraline[Sertraline results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C016101shikoninshikonin results in decreased activity of CYP2B6 protein28941798
C058254sibutraminesibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]23777987
C058254sibutraminesibutramine results in decreased activity of CYP2B6 protein23777987
C058254sibutramineCYP2B6 protein results in increased metabolism of sibutramine24038852
D019821SimvastatinSimvastatin results in increased expression of CYP2B6 mRNA15802384
D020123SirolimusSirolimus results in increased expression of CYP2B6 mRNA25929522
C017947sodium arsenitesodium arsenite affects the methylation of CYP2B6 gene28589171
C471405sorafenibCYP2B6 protein results in increased reduction of sorafenib analog25489883
C012042steviolsteviol results in increased expression of CYP2B6 mRNA28887089
D013442SulfinpyrazoneSulfinpyrazone results in increased expression of CYP2B6 protein14977870
D013629TamoxifenCYP2B6 protein results in increased metabolism of Tamoxifen29285606
D013629Tamoxifen"[CYP2B6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
D013629TamoxifenTamoxifen metabolite results in increased activity of CYP2B6 protein29285606
D013629TamoxifenTamoxifen results in increased expression of CYP2B6 protein19812351
C082026tebufenozidetebufenozide results in increased expression of CYP2B6 mRNA22310298
D013739TestosteroneCYP2B6 protein results in increased hydroxylation of Testosterone19833192
D013739TestosteroneCYP2B6 protein results in increased metabolism of Testosterone12464242
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CYP2B6 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP2B6 mRNA23669205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP2B6 mRNA20106945
D013750TetrachloroethyleneCYP2B6 protein results in increased metabolism of Tetrachloroethylene11684365
D013792ThalidomideThalidomide results in increased expression of CYP2B6 mRNA24460184|2849604
D013827ThiabendazoleThiabendazole results in increased expression of CYP2B6 mRNA18570159
D013852ThiotepaCYP2B6 gene SNP affects the export of Thiotepa19076156
D013852ThiotepaCYP2B6 protein affects the susceptibility to Thiotepa19076156
D013852ThiotepaThiotepa inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]18611395
D013852ThiotepaThiotepa inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]23777987
D013852ThiotepaThiotepa results in decreased activity of CYP2B6 protein15769884
D013852ThiotepaThiotepa results in decreased activity of CYP2B6 protein16945988|1961656
D013988TiclopidineTiclopidine binds to and results in decreased activity of CYP2B6 protein28887089
D013988TiclopidineTiclopidine inhibits the reaction [CYP2B6 protein affects the metabolism of Endosulfan]16855053
D013988TiclopidineTiclopidine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]23850985
D013988TiclopidineTiclopidine results in decreased activity of CYP2B6 protein19328226|2385098
D013988TiclopidineTiclopidine inhibits the reaction [Ficusin results in decreased activity of CYP2B6 protein]26335194
C049947tirapazaminePOR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine]10919648
C423915TO-901317TO-901317 inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]23665929
C507866trans-1,2-dihydro-1,2-naphthalenediol"CYP2B6 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediol"16243959
D014191TranylcypromineTranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]23850985
D014191TranylcypromineTranylcypromine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]28119166
D014191TranylcypromineTranylcypromine results in decreased activity of CYP2B6 protein23850985|2811916
C009540triclocarbanESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA]22761658
C009540triclocarbantriclocarban results in increased expression of CYP2B6 mRNA22761658
D013721TriethylenephosphoramideCYP2B6 gene SNP affects the export of Triethylenephosphoramide19076156
D013721TriethylenephosphoramideCYP2B6 protein affects the susceptibility to Triethylenephosphoramide19076156
D014274TrifluralinCYP2B6 protein results in increased metabolism of and results in decreased susceptibility to Trifluralin15853388
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP2B6 mRNA"26179874
C057693troglitazone[Oleic Acid co-treated with troglitazone] results in increased expression of CYP2B6 mRNA24534255
C057693troglitazone[troglitazone results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA17041008
C057693troglitazonetroglitazone results in increased expression of CYP2B6 mRNA17954527|2755195
C057693troglitazonetroglitazone results in increased expression of CYP2B6 protein10752642|1264247
C057693troglitazonetroglitazone results in increased expression of CYP2B6 mRNA28973697
D014363TryptaminesTryptamines analog results in decreased activity of CYP2B6 protein26599973
D014363Tryptamines[Tryptamines analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion26599973
C113580U 0126U 0126 results in decreased expression of CYP2B6 mRNA24819614
C112106UAB 30UAB 30 results in increased activity of CYP2B6 protein19135037
C112106UAB 30UAB 30 results in increased expression of CYP2B6 mRNA19135037
D014635Valproic AcidCYP2B6 protein results in increased metabolism of Valproic Acid16945988
D014635Valproic AcidCYP2B6 protein results in increased susceptibility to Valproic Acid28762043
D014635Valproic AcidValproic Acid results in increased expression of CYP2B6 mRNA29154799
C052875verbenoneCYP2B6 protein results in increased metabolism of verbenone12867494
D014801Vitamin AVitamin A affects the expression of CYP2B6 mRNA16230703
D002762CholecalciferolCholecalciferol metabolite results in increased expression of CYP2B611991950
C574123walrycin Awalrycin A results in increased expression of CYP2B6 mRNA22314385
D014859WarfarinCYP2B6 protein results in increased hydroxylation of Warfarin12637241

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-IDA19651758  
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0008392arachidonic acid epoxygenase activity-IBA21873635  
GO:0008395steroid hydroxylase activity-IBA21873635  
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IDA20061448  
GO ID GO Term Qualifier Evidence PubMed
GO:0006082organic acid metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-IDA20061448  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0008202steroid metabolic process-IMP18356043  
GO:0017144drug metabolic process-IDA19651758  
GO:0017144drug metabolic process-IMP18356043  
GO:0042180cellular ketone metabolic process-IDA19651758  
GO:0042738exogenous drug catabolic process-IBA21873635  
GO:0042738exogenous drug catabolic process-IDA19029318  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IDA19651758  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211935Fatty acidsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211981XenobioticsTAS
R-HSA-211999CYP2E1 reactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25872594Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. (2015 May)Toselli FAlcohol Clin Exp Res
21715435Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens. (2011 Sep)Wyen CJ Antimicrob Chemother
28699698Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction. (2017 Dec)Chiang YCJ Cell Mol Med
8619884Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. (1996 Feb 23)Hakkola JBiochem Pharmacol
21289075Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. (2011 May)Sridar CDrug Metab Dispos
29681089Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida. (2018 May)Padula AMAm J Med Genet A
17654295Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. (2007 Aug)David SPNicotine Tob Res
27255113Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers. (2016 Aug)Masters ARJ Pharmacol Exp Ther
25556837Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity. (2015 Jun)Mouly SBr J Clin Pharmacol
25655887Pharmacogenetics of nicotine and associated smoking behaviors. (2015)Tanner JACurr Top Behav Neurosci
20966044Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes. (2011 Jan)Washio IDrug Metab Dispos
26648056Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes. (2016)Raunio HDrug Metab Lett
16125881Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene. (2005 Dec 30)Ma MToxicol Lett
23591849Pilot study of CYP2B6 genetic variation to explore the contribution of nitrosamine activation to lung carcinogenesis. (2013 Apr 16)Wassenaar CAInt J Mol Sci
27495292Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4'-OH-bupropion in vitro. (2016 Oct)Sager JEDrug Metab Dispos
24831655CYP2B6 516G>T (rs3745274) and smoking status are associated with efavirenz plasma concentration in a Serbian cohort of HIV patients. (2014 Dec)Olagunju ATher Drug Monit
26046844Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes. (2015)Zhang HPLoS One
16785264Drugs and genotypes: how pharmacogenetic information could improve smoking cessation treatment. (2006 Jul)Lee AMJ Psychopharmacol
18219560Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes. (2008 Jun)Coles RPharm Res
21053990Effect of intrinsic and extrinsic factors on the clinical pharmacokinetics and pharmacodynamics of prasugrel. (2010 Dec)Small DSClin Pharmacokinet
7788860Expression of cytochrome P450 and microsomal epoxide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes. (1995 Jun)Farin FMCarcinogenesis
23149928CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. (2012 Dec)Zhu AZClin Pharmacol Ther
21266057Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. (2011 Jan 25)Cox LSTrials
25652250Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration. (2015 Jul)Garcia KLNeuropsychopharmacology
16309716CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment. (2006 Mar)Lee AMNeuropharmacology
16011913HPLC assay for bupropion and its major metabolites in human plasma. (2005 Sep 5)Loboz KKJ Chromatogr B Analyt Technol Biomed Life Sci
19702527Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6. (2009 Sep)Mo SLCurr Drug Metab
22969879Association between cytochrome P450 promoter polymorphisms and ischemic stroke. (2012 Feb)Kim SKExp Ther Med
9806171Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. (1998 Oct)Crawford ELCarcinogenesis
22048466Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. (2012 Feb)King DPNeuropsychopharmacology
21589866Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response. (2011 May 12)Fonseca FPLoS One
26153084CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy. (2015 Sep)Tomaz PREur J Clin Pharmacol
12814665Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. (2003 Jul)Miksys SNeuropharmacology
24153159Association of the CYP2B6 c.516G>T polymorphism with high blood propofol concentrations in women from northern Greece. (2014)Mastrogianni ODrug Metab Pharmacokinet
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