| C046783 | 11,12-epoxy-5,8,14-eicosatrienoic acid | "CYP2C8 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid" | 12675279 |
| C046783 | 11,12-epoxy-5,8,14-eicosatrienoic acid | "[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid" | 25160618 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | [NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C046782 | 14,15-epoxy-5,8,11-eicosatrienoic acid | "CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid" | 12675279 |
| C046782 | 14,15-epoxy-5,8,11-eicosatrienoic acid | "[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid" | 25160618 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "CYP2C8 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP2C8 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene metabolite" | 29285606 |
| C035342 | 1,4-naphthoquinone | "CYP2C8 protein results in increased abundance of 1,4-naphthoquinone" | 16243959 |
| C486136 | 16-O-demethylaconitine | [Gemfibrozil results in decreased activity of CYP2C8 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| C478004 | 1-hydroxy-2,3,5-trimethoxyxanthone | "CYP2C8 protein results in increased metabolism of 1-hydroxy-2,3,5-trimethoxyxanthone" | 24380714 |
| C029350 | 1-naphthol | CYP2C8 protein results in increased abundance of 1-naphthol | 16243959 |
| C487366 | 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid | "CYP2C8 protein polymorphism affects the hydroxylation of 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid" | 29203276 |
| C024336 | 1-phenylazo-2-naphthol | CYP2C8 protein results in increased oxidation of 1-phenylazo-2-naphthol | 17159775 |
| C055987 | 20-hydroxy-5,8,11,14-eicosatetraenoic acid | "[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid" | 25160618 |
| C036990 | 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline | "2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CYP2C8 mRNA" | 20816883 |
| C586542 | 2'-(glutathion-S-yl)-deschlorodiclofenac | [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac | 24246759 |
| C109602 | 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate | "3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate results in decreased activity of CYP2C8 protein" | 16049129 |
| C109602 | 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate | "CYP2C8 protein affects the metabolism of 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate" | 16049129 |
| C008745 | 4,4'-bisphenol F | "CYP2C8 protein results in increased glutathionylation of 4,4'-bisphenol F" | 23470418 |
| C008745 | 4,4'-bisphenol F | "CYP2C8 protein results in increased hydroxylation of 4,4'-bisphenol F" | 23470418 |
| C570106 | 4,4'-cyclohexylidenebisphenol | "CYP2C8 protein results in increased glutathionylation of 4,4'-cyclohexylidenebisphenol" | 23470418 |
| C570106 | 4,4'-cyclohexylidenebisphenol | "CYP2C8 protein results in increased glutathionylation of 4,4'-cyclohexylidenebisphenol metabolite" | 23470418 |
| C570106 | 4,4'-cyclohexylidenebisphenol | "CYP2C8 protein results in increased hydroxylation of 4,4'-cyclohexylidenebisphenol" | 23470418 |
| C583074 | 4,4'-hexafluorisopropylidene diphenol | "CYP2C8 protein results in increased hydroxylation of 4,4'-hexafluorisopropylidene diphenol" | 23470418 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | 4-hydroxy-N-desmethyltamoxifen results in decreased activity of CYP2C8 protein | 29285606 |
| C019429 | 4-hydroxyretinoic acid | CYP2C8 protein results in increased chemical synthesis of 4-hydroxyretinoic acid | 10874126 |
| C028690 | 4-isopropylphenol | CYP2C8 protein results in increased glutathionylation of 4-isopropylphenol | 23470418 |
| C002202 | 4-oxoretinoic acid | CYP2C8 protein results in increased chemical synthesis of 4-oxoretinoic acid | 10874126 |
| C502236 | 5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione | "CYP2C8 protein results in increased hydroxylation of 5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione" | 15708677 |
| C040997 | 5-bromotryptamine | 5-bromotryptamine analog results in decreased activity of CYP2C8 protein | 26599973 |
| C040997 | 5-bromotryptamine | [5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| C529169 | 5-chlorotryptamine | 5-chlorotryptamine analog results in decreased activity of CYP2C8 protein | 26599973 |
| C529169 | 5-chlorotryptamine | [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| C034536 | 5-fluorotryptamine | 5-fluorotryptamine analog results in decreased activity of CYP2C8 protein | 26599973 |
| C034536 | 5-fluorotryptamine | [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| C000588958 | 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid | 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid results in decreased activity of CYP2C8 protein | 23631744 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime binds to NR1I3 protein] which binds to CYP2C8 promoter" | 15933212 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C8 mRNA" | 15933212 |
| C086219 | 6-hydroxytaxol | CYP2C8 protein results in increased chemical synthesis of 6-hydroxytaxol | 12401345 |
| C050715 | 8,9-epoxyeicosatrienoic acid | "[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 8,9-epoxyeicosatrienoic acid" | 25160618 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of CYP2C8 mRNA | 29067470 |
| D000157 | Aconitine | CYP2C8 protein results in increased metabolism of Aconitine | 21277363 |
| D000157 | Aconitine | [Gemfibrozil results in decreased activity of CYP2C8 protein] which affects the chemical synthesis of Aconitine metabolite | 21277363 |
| C016601 | afimoxifene | afimoxifene results in decreased activity of CYP2C8 protein | 29285606 |
| C016601 | afimoxifene | CYP2C8 protein results in increased metabolism of afimoxifene | 29285606 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of CYP2C8 protein | 20106945 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of CYP2C8 mRNA | 22100608|2715375 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of CYP2C8 gene | 27153756 |
| C409045 | almotriptan | CYP2C8 protein results in decreased methylation of almotriptan | 12642466 |
| D000632 | Aminopyrine | Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] | 26763401 |
| D000632 | Aminopyrine | CYP2C8 protein results in decreased methylation of Aminopyrine | 26763401 |
| D000632 | Aminopyrine | Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] | 26763401 |
| D000638 | Amiodarone | Amiodarone results in decreased activity of CYP2C8 protein | 15304522 |
| D000638 | Amiodarone | CYP2C8 protein results in decreased susceptibility to Amiodarone | 26477383 |
| D000638 | Amiodarone | CYP2C8 protein results in increased metabolism of Amiodarone | 15716363 |
| D000638 | Amiodarone | torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein] | 15304522 |
| D000655 | Amodiaquine | [5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| D000655 | Amodiaquine | [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| D000655 | Amodiaquine | [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| D000655 | Amodiaquine | CYP2C8 protein affects the metabolism of Amodiaquine | 12920490|1562658 |
| D000655 | Amodiaquine | CYP2C8 protein results in increased metabolism of Amodiaquine | 15155557|1560180 |
| D000655 | Amodiaquine | [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| D000655 | Amodiaquine | [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine | 28478157 |
| D000655 | Amodiaquine | Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine] | 28119166 |
| D000655 | Amodiaquine | [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein | 15771232 |
| D000655 | Amodiaquine | [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| C094705 | amodiaquine quinoneimine | CYP2C8 protein results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| C094705 | amodiaquine quinoneimine | [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| D000658 | Amoxicillin | Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] | 26763401 |
| D000658 | Amoxicillin | Amoxicillin results in decreased activity of CYP2C8 protein | 26763401 |
| D016718 | Arachidonic Acid | CYP2C8 protein results in increased metabolism of Arachidonic Acid | 12675279 |
| D016718 | Arachidonic Acid | [CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased metabolism of Arachidonic Acid | 25160618 |
| D016718 | Arachidonic Acid | CYP2C8 protein modified form results in increased metabolism of Arachidonic Acid | 25160618 |
| D001095 | Arachidonic Acids | CYP2C8 protein affects the metabolism of Arachidonic Acids | 15933212 |
| D004958 | Estradiol | Estradiol results in decreased expression of CYP2C8 mRNA | 20106945 |
| C006780 | bisphenol A | bisphenol A results in decreased activity of CYP2C8 protein | 10784435 |
| C006780 | bisphenol A | CYP2C8 protein results in increased glutathionylation of bisphenol A | 23470418 |
| C006780 | bisphenol A | CYP2C8 protein results in increased glutathionylation of bisphenol A metabolite | 23470418 |
| C006780 | bisphenol A | CYP2C8 protein results in increased hydroxylation of bisphenol A | 23470418 |
| C006780 | bisphenol A | CYP2C8 protein results in increased hydroxylation of bisphenol A metabolite | 23470418 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of CYP2C8 mRNA | 25181051 |
| C010831 | bufuralol | CYP2C8 protein results in increased hydroxylation of bufuralol | 9429232 |
| D002047 | Buprenorphine | CYP2C8 protein affects the metabolism of Buprenorphine | 16010532 |
| C077793 | candesartan cilexetil | candesartan cilexetil results in decreased activity of CYP2C8 protein | 15601807 |
| D002220 | Carbamazepine | Carbamazepine results in increased expression of CYP2C8 mRNA | 17112801 |
| D002220 | Carbamazepine | CYP2C8 protein affects the metabolism of Carbamazepine | 15286053|1591535 |
| D002220 | Carbamazepine | CYP2C8 protein results in increased metabolism of Carbamazepine | 12464242 |
| D002220 | Carbamazepine | Probenecid promotes the reaction [CYP2C8 protein affects the metabolism of Carbamazepine] | 15915352 |
| D002220 | Carbamazepine | CYP2C8 protein results in increased metabolism of Carbamazepine | 10907977 |
| C012227 | carbamazepine epoxide | CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide | 15915352 |
| C012227 | carbamazepine epoxide | Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide] | 15915352 |
| C086276 | cerivastatin | CYP2C8 gene mutant form affects the susceptibility to cerivastatin | 15365880 |
| C086276 | cerivastatin | CYP2C8 protein results in increased metabolism of cerivastatin | 12464242|1536588 |
| D002635 | Chenodeoxycholic Acid | Chenodeoxycholic Acid results in decreased expression of CYP2C8 mRNA | 27174168 |
| D020111 | Chlorodiphenyl (54% Chlorine) | Chlorodiphenyl (54% Chlorine) results in increased expression of CYP2C8 mRNA | 17851650 |
| D002738 | Chloroquine | CYP2C8 polymorphism affects the metabolism of Chloroquine | 19560616 |
| D002738 | Chloroquine | CYP2C8 protein affects the metabolism of Chloroquine | 12920490 |
| D002746 | Chlorpromazine | CYP2C8 protein results in decreased susceptibility to Chlorpromazine | 26477383 |
| D002793 | Cholic Acids | [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2C8 mRNA | 27344345 |
| C045316 | cinitapride | CYP2C8 protein results in increased metabolism of cinitapride | 17437965 |
| C029010 | cinnamic acid | cinnamic acid analog results in decreased activity of CYP2C8 protein | 15072549 |
| D002995 | Clofibric Acid | Clofibric Acid results in increased activity of CYP2C8 protein | 15771232 |
| D002995 | Clofibric Acid | Clofibric Acid results in increased expression of CYP2C8 mRNA | 15771232 |
| D002995 | Clofibric Acid | Clofibric Acid results in increased expression of CYP2C8 protein | 15771232 |
| C055162 | clopidogrel | CYP2C8 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite | 19170597 |
| D003022 | Clotrimazole | Clotrimazole results in decreased activity of CYP2C8 protein | 15601807 |
| D003024 | Clozapine | CYP2C8 protein results in increased metabolism of Clozapine | 18809730|2732096 |
| C079149 | clozapine N-oxide | CYP2C8 protein results in increased abundance of clozapine N-oxide | 27320963 |
| D003042 | Cocaine | Cocaine results in decreased expression of CYP2C8 mRNA | 16188404 |
| D003042 | Cocaine | Cocaine results in decreased expression of CYP2C8 protein | 16188404 |
| D009249 | NADP | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | [NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | 24120545 |
| D009249 | NADP | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C007164 | cumene hydroperoxide | CYP2C8 protein affects the oxidation of cumene hydroperoxide | 17478480 |
| D053138 | Cyclohexenes | Cyclohexenes analog inhibits the reaction [CYP2C8 protein results in increased metabolism of Paclitaxel] | 20452209 |
| D003520 | Cyclophosphamide | CYP2C8 results in increased activity of Cyclophosphamide | 9241661 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of CYP2C8 mRNA | 20106945 |
| D016572 | Cyclosporine | CYP2C8 protein affects the oxidation of Cyclosporine | 7870052 |
| D016572 | Cyclosporine | Cyclosporine results in decreased activity of CYP2C8 protein | 18769365 |
| C017160 | cypermethrin | cypermethrin results in increased expression of CYP2C8 mRNA | 22310298 |
| C017180 | decamethrin | decamethrin results in increased expression of CYP2C8 mRNA | 22310298 |
| D003671 | DEET | DEET results in increased expression of CYP2C8 mRNA | 27091632 |
| D003671 | DEET | [fipronil co-treated with DEET] results in increased expression of CYP2C8 mRNA | 27091632 |
| C047386 | desethylamodiaquine | CYP2C8 protein results in increased chemical synthesis of desethylamodiaquine | 15155557|2847815 |
| C047386 | desethylamodiaquine | [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine | 28478157 |
| C047386 | desethylamodiaquine | CYP2C8 protein results in increased metabolism of desethylamodiaquine | 28478157 |
| D003907 | Dexamethasone | [Dexamethasone binds to NR3C1 protein] which binds to CYP2C8 promoter | 15933212 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of CYP2C8 mRNA | 15933212|1911856 |
| C036042 | dicyclohexyl phthalate | dicyclohexyl phthalate results in increased expression of CYP2C8 mRNA | 26924002 |
| C039602 | diosmetin | diosmetin results in decreased activity of CYP2C8 protein | 28867436 |
| D004294 | Domperidone | CYP2C8 protein results in increased hydroxylation of Domperidone | 15327587 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased activity of CYP2C8 protein | 15601807 |
| D015736 | Felodipine | Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine] | 28119166 |
| D015736 | Felodipine | Felodipine results in decreased activity of CYP2C8 protein | 15601807|2811916 |
| D005278 | Fenitrothion | Fenitrothion results in decreased activity of CYP2C8 protein | 20183062 |
| D011345 | Fenofibrate | Fenofibrate results in decreased activity of CYP2C8 protein | 15601807 |
| D011345 | Fenofibrate | Fenofibrate results in increased expression of CYP2C8 mRNA | 25572481 |
| C006012 | fenofibric acid | fenofibric acid results in increased activity of CYP2C8 protein | 15771232 |
| C006012 | fenofibric acid | fenofibric acid results in increased expression of CYP2C8 mRNA | 15771232 |
| C006012 | fenofibric acid | fenofibric acid results in increased expression of CYP2C8 protein | 15771232 |
| C017690 | fenvalerate | fenvalerate results in increased expression of CYP2C8 mRNA | 22310298 |
| C082360 | fipronil | [fipronil co-treated with DEET] results in increased expression of CYP2C8 mRNA | 27091632 |
| C082360 | fipronil | fipronil results in increased expression of CYP2C8 mRNA | 27091632 |
| D044947 | Flavonolignans | Flavonolignans results in decreased activity of CYP2C8 protein | 28457856 |
| D005473 | Fluoxetine | Fluoxetine results in decreased activity of CYP2C8 protein | 15304522 |
| D005473 | Fluoxetine | torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein] | 15304522 |
| D015248 | Gemfibrozil | [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein | 15771232 |
| D015248 | Gemfibrozil | Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone] | 15900286 |
| D015248 | Gemfibrozil | Gemfibrozil metabolite results in decreased activity of CYP2C8 protein | 16042675 |
| D015248 | Gemfibrozil | Gemfibrozil results in decreased activity of CYP2C8 protein | 15771232 |
| D015248 | Gemfibrozil | [Gemfibrozil results in decreased activity of CYP2C8 protein] which affects the chemical synthesis of Aconitine metabolite | 21277363 |
| D015248 | Gemfibrozil | [Gemfibrozil results in decreased activity of CYP2C8 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| D015248 | Gemfibrozil | Gemfibrozil results in decreased expression of CYP2C8 protein | 15771232 |
| D015248 | Gemfibrozil | Gemfibrozil results in increased expression of CYP2C8 mRNA | 15771232 |
| C094370 | gemfibrozil 1-O-acylglucuronide | CYP2C8 protein results in increased oxidation of gemfibrozil 1-O-acylglucuronide | 19445523 |
| C094370 | gemfibrozil 1-O-acylglucuronide | [CYP2C8 protein results in increased oxidation of gemfibrozil 1-O-acylglucuronide] which results in decreased activity of CYP2C8 protein | 19445523 |
| C094370 | gemfibrozil 1-O-acylglucuronide | [CYP2C8 protein results in increased oxidation of gemfibrozil 1-O-acylglucuronide] which results in increased alkylation of CYP2C8 protein | 19445523 |
| C094370 | gemfibrozil 1-O-acylglucuronide | gemfibrozil 1-O-acylglucuronide binds to CYP2C8 protein | 19445523 |
| C094370 | gemfibrozil 1-O-acylglucuronide | gemfibrozil 1-O-acylglucuronide results in decreased activity of CYP2C8 protein | 19445523 |
| D005978 | Glutathione | [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac | 24246759 |
| C058309 | hypaconitine | CYP2C8 protein results in increased metabolism of hypaconitine | 21550385 |
| D007052 | Ibuprofen | CYP2C8 gene polymorphism affects the metabolism of Ibuprofen | 15606441 |
| D007052 | Ibuprofen | CYP2C8 gene polymorphism results in decreased metabolism of Ibuprofen | 15289789 |
| D007052 | Ibuprofen | CYP2C8 gene polymorphism results in increased metabolism of Ibuprofen | 18694831 |
| D007069 | Ifosfamide | CYP2C8 results in increased activity of Ifosfamide | 9241661 |
| D000068877 | Imatinib Mesylate | CYP2C8 protein results in decreased methylation of Imatinib Mesylate | 20977456 |
| D007211 | Indoles | CYP2C8 protein results in increased glutathionylation of Indoles | 22429462 |
| C081309 | irbesartan | irbesartan results in decreased activity of CYP2C8 protein | 15601807 |
| D007538 | Isoniazid | Isoniazid results in decreased activity of CYP2C8 protein | 15304522 |
| D007538 | Isoniazid | torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein] | 15304522 |
| D007654 | Ketoconazole | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D007654 | Ketoconazole | Ketoconazole results in decreased activity of CYP2C8 protein | 14709627|1560180 |
| D064747 | Lansoprazole | CYP2C8 protein affects the metabolism of Lansoprazole | 7870052 |
| D064747 | Lansoprazole | CYP2C8 protein results in increased hydroxylation of Lansoprazole | 8627562 |
| C070840 | licochalcone A | licochalcone A results in decreased activity of CYP2C8 protein | 26100226 |
| D017336 | Loratadine | Loratadine results in decreased activity of CYP2C8 protein | 15601807 |
| D008148 | Lovastatin | Lovastatin results in decreased activity of CYP2C8 protein | 15601807 |
| D008525 | Medroxyprogesterone | Medroxyprogesterone results in decreased activity of CYP2C8 protein | 15601807 |
| D008731 | Methoxychlor | CYP2C8 protein results in decreased methylation of Methoxychlor | 12167570|1243379 |
| D008777 | Methyltestosterone | [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2C8 mRNA | 27344345 |
| D000068656 | Mometasone Furoate | Mometasone Furoate results in decreased activity of CYP2C8 protein | 15601807 |
| C517284 | monomethyl phthalate | monomethyl phthalate affects the expression of CYP2C8 mRNA | 26924002 |
| C093875 | montelukast | CYP2C8 protein results in increased metabolism of montelukast | 19309152 |
| C093875 | montelukast | montelukast results in decreased activity of CYP2C8 protein | 15601807|1799467 |
| C093875 | montelukast | montelukast results in decreased activity of CYP2C8 protein | 16670899|1985359 |
| D018721 | Muscarinic Agonists | CYP2C8 protein affects the metabolism of Muscarinic Agonists | 16041192 |
| D009173 | Mycophenolic Acid | CYP2C8 protein results in increased methylation of Mycophenolic Acid | 15570183 |
| C031721 | naphthalene | naphthalene results in increased expression of CYP2C8 mRNA | 20500019 |
| C057222 | neferine | CYP2C8 protein results in increased glutathionylation of neferine metabolite | 25451576 |
| C057222 | neferine | CYP2C8 protein results in increased metabolism of and results in decreased methylation of neferine | 25451576 |
| D009529 | Nicardipine | CYP2C8 protein affects the metabolism of Nicardipine | 15863898 |
| D009529 | Nicardipine | Nicardipine results in decreased activity of CYP2C8 protein | 15863898 |
| D009543 | Nifedipine | Nifedipine results in decreased activity of CYP2C8 protein | 15601807 |
| C574385 | N,N-didesmethyl-4-hydroxytamoxifen | "CYP2C8 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen" | 29285606 |
| C574385 | N,N-didesmethyl-4-hydroxytamoxifen | "[CYP2C8 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen] which results in increased abundance of N,N-didesmethyl-4-hydroxytamoxifen" | 29285606 |
| C574385 | N,N-didesmethyl-4-hydroxytamoxifen | "N,N-didesmethyl-4-hydroxytamoxifen results in decreased activity of CYP2C8 protein" | 29285606 |
| C058272 | norclozapine | CYP2C8 protein results in increased chemical synthesis of norclozapine | 18809730 |
| D009661 | Nortriptyline | Nortriptyline results in decreased activity of CYP2C8 protein | 15304522 |
| D009661 | Nortriptyline | torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein] | 15304522 |
| C464660 | obeticholic acid | obeticholic acid results in decreased expression of CYP2C8 mRNA | 27939613 |
| D062367 | ortho-Aminobenzoates | ortho-Aminobenzoates analog results in decreased activity of CYP2C8 protein | 17994679 |
| D062367 | ortho-Aminobenzoates | ortho-Aminobenzoates results in decreased activity of CYP2C8 protein | 18477506 |
| C005419 | oxybutynin | oxybutynin results in decreased activity of CYP2C8 protein | 15601807 |
| D017239 | Paclitaxel | Cyclohexenes analog inhibits the reaction [CYP2C8 protein results in increased metabolism of Paclitaxel] | 20452209 |
| D017239 | Paclitaxel | CYP2C8 gene SNP affects the susceptibility to Paclitaxel | 27736846 |
| D017239 | Paclitaxel | CYP2C8 mRNA results in increased susceptibility to Paclitaxel | 15239142 |
| D017239 | Paclitaxel | CYP2C8 protein affects the metabolism of Paclitaxel | 15901749|1593321 |
| D017239 | Paclitaxel | CYP2C8 protein results in increased hydroxylation of Paclitaxel | 21964418 |
| D017239 | Paclitaxel | CYP2C8 protein results in increased metabolism of Paclitaxel | 12401345|1246424 |
| D017239 | Paclitaxel | CYP2C8 protein results in increased oxidation of Paclitaxel | 17478480 |
| D017239 | Paclitaxel | perfluorooctane sulfonic acid inhibits the reaction [CYP2C8 protein results in increased hydroxylation of Paclitaxel] | 21964418 |
| D017239 | Paclitaxel | sitaxsentan inhibits the reaction [CYP2C8 protein results in increased metabolism of Paclitaxel] | 23721565 |
| D017239 | Paclitaxel | CYP2C8 protein results in increased hydrolysis of Paclitaxel | 25160618 |
| D010278 | Parathion | CYP2C8 protein affects the metabolism of Parathion | 12669189 |
| C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid inhibits the reaction [CYP2C8 protein results in increased hydroxylation of Paclitaxel] | 21964418 |
| C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid results in increased expression of CYP2C8 mRNA | 27153767 |
| D010622 | Phencyclidine | CYP2C8 protein affects the metabolism of Phencyclidine | 16782764 |
| D010624 | Phenelzine | Phenelzine results in decreased activity of CYP2C8 protein | 15304522 |
| D010624 | Phenelzine | torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein] | 15304522 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of CYP2C8 mRNA | 19118567|2231029 |
| C060836 | pioglitazone | CYP2C8 protein affects the metabolism of pioglitazone | 15900286 |
| C060836 | pioglitazone | Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone] | 15900286 |
| C060836 | pioglitazone | pioglitazone results in decreased activity of CYP2C8 protein | 12642470 |
| D010878 | Piperacillin | Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] | 26763401 |
| D010878 | Piperacillin | Piperacillin results in decreased activity of CYP2C8 protein | 26763401 |
| D010936 | Plant Extracts | Plant Extracts results in decreased activity of CYP2C8 protein | 20828605|2845785 |
| D011339 | Probenecid | Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide] | 15915352 |
| D011339 | Probenecid | Probenecid promotes the reaction [CYP2C8 protein affects the metabolism of Carbamazepine] | 15915352 |
| D011374 | Progesterone | Progesterone results in increased expression of CYP2C8 mRNA | 22837389 |
| D011433 | Propranolol | CYP2C8 protein results in increased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | CYP2C8 protein results in increased oxidation of Propranolol | 19853591 |
| D011794 | Quercetin | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D011794 | Quercetin | Quercetin results in decreased activity of CYP2C8 protein | 15155557|1560180 |
| D011794 | Quercetin | [Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerine | 11502731 |
| D020849 | Raloxifene Hydrochloride | Raloxifene Hydrochloride results in decreased activity of CYP2C8 protein | 15601807 |
| C072379 | repaglinide | CYP2C8 protein affects the metabolism of repaglinide | 16042675 |
| D012293 | Rifampin | [Rifampin binds to NR1I2 protein] which binds to CYP2C8 promoter | 15933212 |
| D012293 | Rifampin | Rifampin results in increased activity of CYP2C8 protein | 15771232|2212699 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP2C8 mRNA | 12040753|1577123 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP2C8 protein | 15771232 |
| D019438 | Ritonavir | Ritonavir results in decreased activity of CYP2C8 protein | 15601807 |
| C057006 | Ro 21-5104 | Ro 21-5104 results in increased expression of CYP2C8 mRNA | 25313206 |
| C089730 | rosiglitazone | CYP2C8 gene alternative form results in decreased metabolism of rosiglitazone | 21245287 |
| C089730 | rosiglitazone | CYP2C8 gene polymorphism affects the metabolism of rosiglitazone | 19129086 |
| C089730 | rosiglitazone | CYP2C8 protein alternative form results in increased metabolism of rosiglitazone | 17178266 |
| C089730 | rosiglitazone | CYP2C8 protein results in increased metabolism of rosiglitazone | 12464242|1717826 |
| C089730 | rosiglitazone | rosiglitazone results in decreased activity of CYP2C8 protein | 12642470 |
| D000068299 | Salmeterol Xinafoate | Salmeterol Xinafoate results in decreased activity of CYP2C8 protein | 15601807 |
| C081294 | satraplatin | satraplatin results in decreased activity of CYP2C8 protein | 24882083 |
| C009238 | senkirkine | senkirkine results in decreased expression of CYP2C8 mRNA | 26100227 |
| D012822 | Silicon Dioxide | Silicon Dioxide analog results in decreased expression of CYP2C8 mRNA | 25895662 |
| C440975 | silybin | silybin results in decreased activity of CYP2C8 protein | 28457856 |
| D019821 | Simvastatin | Simvastatin results in decreased activity of CYP2C8 protein | 15601807 |
| C106276 | sitaxsentan | sitaxsentan inhibits the reaction [CYP2C8 protein results in increased metabolism of Paclitaxel] | 23721565 |
| D013148 | Spironolactone | Spironolactone results in decreased activity of CYP2C8 protein | 15601807 |
| C001873 | sporidesmin | MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA] | 28193462 |
| C001873 | sporidesmin | sporidesmin affects the expression of CYP2C8 mRNA | 28193462 |
| D013411 | Sulfadiazine | CYP2C8 protein results in increased hydroxylation of Sulfadiazine | 15843491 |
| D013442 | Sulfinpyrazone | Sulfinpyrazone results in decreased activity of CYP2C8 protein | 12464242 |
| D016559 | Tacrolimus | Tacrolimus results in decreased activity of CYP2C8 protein | 18769365 |
| D013629 | Tamoxifen | Tamoxifen metabolite results in increased activity of CYP2C8 protein | 29285606 |
| D013629 | Tamoxifen | Tamoxifen results in decreased activity of CYP2C8 protein | 15601807|2928560 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of CYP2C8 mRNA | 20106945 |
| D013750 | Tetrachloroethylene | CYP2C8 protein results in increased metabolism of Tetrachloroethylene | 11684365 |
| C109005 | thiocoraline | CYP2C8 protein affects the metabolism of thiocoraline | 15122071 |
| D008063 | Thioctic Acid | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D013974 | Thyroxine | Thyroxine results in decreased activity of CYP2C8 protein | 15601807 |
| D013988 | Ticlopidine | CYP2C8 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite | 19170597 |
| D014044 | Tolbutamide | CYP2C8 protein results in increased hydroxylation of Tolbutamide | 15843491 |
| C026116 | torsemide | CYP2C8 protein results in increased metabolism of torsemide | 15304522 |
| C026116 | torsemide | torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein] | 15304522 |
| C026116 | torsemide | torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein] | 15304522 |
| C026116 | torsemide | torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein] | 15304522 |
| C026116 | torsemide | torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein] | 15304522 |
| C026116 | torsemide | torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein] | 15304522 |
| C026116 | torsemide | torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein] | 15304522 |
| C507866 | trans-1,2-dihydro-1,2-naphthalenediol | "CYP2C8 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediol" | 16243959 |
| D014191 | Tranylcypromine | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D014212 | Tretinoin | CYP2C8 protein affects the metabolism of Tretinoin | 15933212 |
| D014212 | Tretinoin | CYP2C8 protein results in increased hydroxylation of Tretinoin | 10874126 |
| D014212 | Tretinoin | CYP2C8 protein results in increased metabolism of Tretinoin | 12464242 |
| D014295 | Trimethoprim | CYP2C8 protein results in increased metabolism of Trimethoprim | 12464242 |
| D014295 | Trimethoprim | Trimethoprim results in decreased activity of CYP2C8 protein | 15570183 |
| C057693 | troglitazone | CYP2C8 protein results in increased metabolism of troglitazone | 19356091 |
| C057693 | troglitazone | troglitazone results in decreased activity of CYP2C8 protein | 12642470 |
| C057693 | troglitazone | troglitazone results in increased expression of CYP2C8 mRNA | 25572481 |
| C057693 | troglitazone | troglitazone results in increased expression of CYP2C8 mRNA | 28973697 |
| D014363 | Tryptamines | Tryptamines analog results in decreased activity of CYP2C8 protein | 26599973 |
| D014363 | Tryptamines | [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine | 26599973 |
| C043425 | vanoxerine | CYP2C8 protein results in decreased degradation of vanoxerine | 11502731 |
| C043425 | vanoxerine | [Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerine | 11502731 |
| D014700 | Verapamil | torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein] | 15304522 |
| D014700 | Verapamil | Verapamil results in decreased activity of CYP2C8 protein | 15304522 |
| D014750 | Vincristine | CYP2C8 gene SNP results in increased susceptibility to Vincristine | 21245421 |
| C574123 | walrycin A | walrycin A results in increased expression of CYP2C8 mRNA | 22314385 |
| C062735 | zafirlukast | zafirlukast results in decreased activity of CYP2C8 protein | 15601807 |
| C062735 | zafirlukast | zafirlukast results in decreased activity of CYP2C8 protein | 16670899 |
| C515050 | zopiclone | CYP2C8 protein results in increased metabolism of zopiclone | 12464242 |