Gene: CYP2C9

1559
CPC9|CYP2C|CYP2C10|CYPIIC9|P450IIC9
cytochrome P450 family 2 subfamily C member 9
protein-coding
10q23.33
Ensembl:ENSG00000138109 MIM:601130 Vega:OTTHUMG00000018805 UniprotKB:P11712
NG_008385.1
PubMed
CD|OD|ND|AD
51   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.079e-1 (AD)  2.080e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4Q30.74
OR4K50.736
DAOA0.733
HIST1H2AA0.73
OR11A10.729
OR4D60.728
OR4A150.724
OR4C120.722
KRTAP6-20.722
OR5T20.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADCY2-0.285
CADM1-0.285
GABRG1-0.28
B3GALT1-0.279
CABLES1-0.277
SLC1A4-0.271
PEX11A-0.262
LGR4-0.261
FUT9-0.257
CDH20-0.255

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB025074-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-OneSmall MoleculeExperimentalTarget
DB03317Heme CSmall MoleculeExperimentalTarget
DB11994DiacereinSmall Molecule13739-02-1Approved|InvestigationalTarget
DB12319BenzbromaroneSmall Molecule3562-84-3Investigational|WithdrawnTarget
DB00062Human Serum AlbuminBiotechDrug9048-46-8ApprovedEnzyme
DB00091CyclosporineSmall Molecule59865-13-3Approved|InvestigationalEnzyme
DB00169CholecalciferolSmall Molecule67-97-0Approved|NutraceuticalEnzyme
DB00175PravastatinSmall Molecule81093-37-0ApprovedEnzyme
DB00176FluvoxamineSmall Molecule54739-18-3Approved|InvestigationalEnzyme
DB00177ValsartanSmall Molecule137862-53-4Approved|InvestigationalEnzyme
DB00184NicotineSmall Molecule54-11-5ApprovedEnzyme
DB00188BortezomibSmall Molecule179324-69-7Approved|InvestigationalEnzyme
DB00191PhentermineSmall Molecule122-09-8Approved|IllicitEnzyme
DB00196FluconazoleSmall Molecule86386-73-4Approved|InvestigationalEnzyme
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00201CaffeineSmall Molecule58-08-2ApprovedEnzyme
DB00203SildenafilSmall Molecule139755-83-2Approved|InvestigationalEnzyme
DB00205PyrimethamineSmall Molecule58-14-0Approved|InvestigationalEnzyme
DB00208TiclopidineSmall Molecule55142-85-3ApprovedEnzyme
DB00213PantoprazoleSmall Molecule102625-70-7ApprovedEnzyme
DB00214TorasemideSmall Molecule56211-40-6ApprovedEnzyme
DB00216EletriptanSmall Molecule143322-58-1Approved|InvestigationalEnzyme
DB00220NelfinavirSmall Molecule159989-64-7ApprovedEnzyme
DB00222GlimepirideSmall Molecule93479-97-1ApprovedEnzyme
DB00224IndinavirSmall Molecule150378-17-9ApprovedEnzyme
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalEnzyme
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalEnzyme
DB00238NevirapineSmall Molecule129618-40-2ApprovedEnzyme
DB00250DapsoneSmall Molecule80-08-0Approved|InvestigationalEnzyme
DB00252PhenytoinSmall Molecule57-41-0ApprovedEnzyme
DB00255DiethylstilbestrolSmall Molecule56-53-1Approved|InvestigationalEnzyme
DB00257ClotrimazoleSmall Molecule23593-75-1ApprovedEnzyme
DB00259SulfanilamideSmall Molecule63-74-1ApprovedEnzyme
DB00263SulfisoxazoleSmall Molecule127-69-5ApprovedEnzyme
DB00266DicoumarolSmall Molecule66-76-2ApprovedEnzyme
DB00277TheophyllineSmall Molecule58-55-9ApprovedEnzyme
DB00281LidocaineSmall Molecule137-58-6ApprovedEnzyme
DB00285VenlafaxineSmall Molecule93413-69-5ApprovedEnzyme
DB00307BexaroteneSmall Molecule153559-49-0Approved|InvestigationalEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
DB00317GefitinibSmall Molecule184475-35-2Approved|InvestigationalEnzyme
DB00321AmitriptylineSmall Molecule50-48-6ApprovedEnzyme
DB00322FloxuridineSmall Molecule50-91-9ApprovedEnzyme
DB00323TolcaponeSmall Molecule134308-13-7Approved|WithdrawnEnzyme
DB00327HydromorphoneSmall Molecule466-99-9Approved|IllicitEnzyme
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalEnzyme
DB00333MethadoneSmall Molecule76-99-3ApprovedEnzyme
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalEnzyme
DB00338OmeprazoleSmall Molecule73590-58-6Approved|InvestigationalEnzyme
DB00342TerfenadineSmall Molecule50679-08-8Approved|WithdrawnEnzyme
DB00343DiltiazemSmall Molecule42399-41-7Approved|InvestigationalEnzyme
DB00347TrimethadioneSmall Molecule127-48-0ApprovedEnzyme
DB00359SulfadiazineSmall Molecule68-35-9Approved|InvestigationalEnzyme
DB00363ClozapineSmall Molecule5786-21-0ApprovedEnzyme
DB00370MirtazapineSmall Molecule85650-52-8ApprovedEnzyme
DB00374TreprostinilSmall Molecule81846-19-7Approved|InvestigationalEnzyme
DB00381AmlodipineSmall Molecule88150-42-9ApprovedEnzyme
DB00396ProgesteroneSmall Molecule57-83-0ApprovedEnzyme
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalEnzyme
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalEnzyme
DB00404AlprazolamSmall Molecule28981-97-7Approved|Illicit|InvestigationalEnzyme
DB00412RosiglitazoneSmall Molecule122320-73-4Approved|InvestigationalEnzyme
DB00418SecobarbitalSmall Molecule76-73-3ApprovedEnzyme
DB00420PromazineSmall Molecule58-40-2ApprovedEnzyme
DB00425ZolpidemSmall Molecule82626-48-0ApprovedEnzyme
DB00439CerivastatinSmall Molecule145599-86-6Approved|WithdrawnEnzyme
DB00440TrimethoprimSmall Molecule738-70-5ApprovedEnzyme
DB00444TeniposideSmall Molecule29767-20-2ApprovedEnzyme
DB00446ChloramphenicolSmall Molecule56-75-7ApprovedEnzyme
DB00448LansoprazoleSmall Molecule103577-45-3Approved|InvestigationalEnzyme
DB00455LoratadineSmall Molecule79794-75-5Approved|InvestigationalEnzyme
DB00468QuinineSmall Molecule130-95-0ApprovedEnzyme
DB00469TenoxicamSmall Molecule59804-37-4ApprovedEnzyme
DB00470DronabinolSmall Molecule1972-08-3Approved|IllicitEnzyme
DB00471MontelukastSmall Molecule158966-92-8ApprovedEnzyme
DB00472FluoxetineSmall Molecule54910-89-3ApprovedEnzyme
DB00482CelecoxibSmall Molecule169590-42-5Approved|InvestigationalEnzyme
DB00495ZidovudineSmall Molecule30516-87-1ApprovedEnzyme
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalEnzyme
DB00502HaloperidolSmall Molecule52-86-8ApprovedEnzyme
DB00503RitonavirSmall Molecule155213-67-5Approved|InvestigationalEnzyme
DB00514DextromethorphanSmall Molecule125-71-3ApprovedEnzyme
DB00515CisplatinSmall Molecule15663-27-1ApprovedEnzyme
DB00531CyclophosphamideSmall Molecule50-18-0Approved|InvestigationalEnzyme
DB00532MephenytoinSmall Molecule50-12-4Investigational|WithdrawnEnzyme
DB00533RofecoxibSmall Molecule162011-90-7Approved|Investigational|WithdrawnEnzyme
DB00540NortriptylineSmall Molecule72-69-5ApprovedEnzyme
DB00544FluorouracilSmall Molecule51-21-8ApprovedEnzyme
DB00549ZafirlukastSmall Molecule107753-78-6Approved|InvestigationalEnzyme
DB00554PiroxicamSmall Molecule36322-90-4Approved|InvestigationalEnzyme
DB00559BosentanSmall Molecule147536-97-8Approved|InvestigationalEnzyme
DB00564CarbamazepineSmall Molecule298-46-4Approved|InvestigationalEnzyme
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalEnzyme
DB00576SulfamethizoleSmall Molecule144-82-1Approved|InvestigationalEnzyme
DB00580ValdecoxibSmall Molecule181695-72-7Approved|Investigational|WithdrawnEnzyme
DB00582VoriconazoleSmall Molecule137234-62-9Approved|InvestigationalEnzyme
DB00586DiclofenacSmall Molecule15307-86-5ApprovedEnzyme
DB00603Medroxyprogesterone acetateSmall Molecule71-58-9Approved|InvestigationalEnzyme
DB00604CisaprideSmall Molecule81098-60-4Approved|Investigational|WithdrawnEnzyme
DB00613AmodiaquineSmall Molecule86-42-0Approved|InvestigationalEnzyme
DB00617ParamethadioneSmall Molecule115-67-3ApprovedEnzyme
DB00619ImatinibSmall Molecule152459-95-5ApprovedEnzyme
DB00622NicardipineSmall Molecule55985-32-5Approved|InvestigationalEnzyme
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalEnzyme
DB00625EfavirenzSmall Molecule154598-52-4Approved|InvestigationalEnzyme
DB00641SimvastatinSmall Molecule79902-63-9ApprovedEnzyme
DB00647DextropropoxypheneSmall Molecule469-62-5Approved|Illicit|Investigational|WithdrawnEnzyme
DB00655EstroneSmall Molecule53-16-7ApprovedEnzyme
DB00661VerapamilSmall Molecule52-53-9ApprovedEnzyme
DB00665NilutamideSmall Molecule63612-50-0Approved|InvestigationalEnzyme
DB00668EpinephrineSmall Molecule51-43-4ApprovedEnzyme
DB00672ChlorpropamideSmall Molecule94-20-2Approved|InvestigationalEnzyme
DB00673AprepitantSmall Molecule170729-80-3Approved|InvestigationalEnzyme
DB00675TamoxifenSmall Molecule10540-29-1ApprovedEnzyme
DB00678LosartanSmall Molecule114798-26-4ApprovedEnzyme
DB00679ThioridazineSmall Molecule50-52-2Approved|WithdrawnEnzyme
DB00682WarfarinSmall Molecule81-81-2ApprovedEnzyme
DB00701AmprenavirSmall Molecule161814-49-9Approved|InvestigationalEnzyme
DB00703MethazolamideSmall Molecule554-57-4ApprovedEnzyme
DB00705DelavirdineSmall Molecule136817-59-9ApprovedEnzyme
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalEnzyme
DB00715ParoxetineSmall Molecule61869-08-7Approved|InvestigationalEnzyme
DB00726TrimipramineSmall Molecule739-71-9ApprovedEnzyme
DB00731NateglinideSmall Molecule105816-04-4Approved|InvestigationalEnzyme
DB00744ZileutonSmall Molecule111406-87-2Approved|Investigational|WithdrawnEnzyme
DB00745ModafinilSmall Molecule68693-11-8Approved|InvestigationalEnzyme
DB00748CarbinoxamineSmall Molecule486-16-8ApprovedEnzyme
DB00749EtodolacSmall Molecule41340-25-4Approved|InvestigationalEnzyme
DB00752TranylcypromineSmall Molecule155-09-9Approved|InvestigationalEnzyme
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalEnzyme
DB00757DolasetronSmall Molecule115956-12-2Approved|InvestigationalEnzyme
DB00758ClopidogrelSmall Molecule113665-84-2ApprovedEnzyme
DB00763MethimazoleSmall Molecule60-56-0ApprovedEnzyme
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalEnzyme
DB00784Mefenamic acidSmall Molecule61-68-7ApprovedEnzyme
DB00788NaproxenSmall Molecule22204-53-1ApprovedEnzyme
DB00794PrimidoneSmall Molecule125-33-7ApprovedEnzyme
DB00796Candesartan cilexetilSmall Molecule145040-37-5ApprovedEnzyme
DB00812PhenylbutazoneSmall Molecule50-33-9ApprovedEnzyme
DB00814MeloxicamSmall Molecule71125-38-7ApprovedEnzyme
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalEnzyme
DB00822DisulfiramSmall Molecule97-77-8ApprovedEnzyme
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalEnzyme
DB00835BrompheniramineSmall Molecule86-22-6ApprovedEnzyme
DB00843DonepezilSmall Molecule120014-06-4ApprovedEnzyme
DB00850PerphenazineSmall Molecule58-39-9ApprovedEnzyme
DB00857TerbinafineSmall Molecule91161-71-6Approved|InvestigationalEnzyme
DB00869DorzolamideSmall Molecule120279-96-1ApprovedEnzyme
DB00870SuprofenSmall Molecule40828-46-4Approved|WithdrawnEnzyme
DB00876EprosartanSmall Molecule133040-01-4ApprovedEnzyme
DB00891SulfapyridineSmall Molecule144-83-2ApprovedEnzyme
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
DB00904OndansetronSmall Molecule99614-02-5ApprovedEnzyme
DB00907CocaineSmall Molecule50-36-2Approved|IllicitEnzyme
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalEnzyme
DB00916MetronidazoleSmall Molecule443-48-1ApprovedEnzyme
DB00921BuprenorphineSmall Molecule52485-79-7Approved|Illicit|InvestigationalEnzyme
DB00936Salicylic acidSmall Molecule69-72-7Approved|InvestigationalEnzyme
DB00943ZalcitabineSmall Molecule7481-89-2Approved|InvestigationalEnzyme
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedEnzyme
DB00946PhenprocoumonSmall Molecule435-97-2Approved|InvestigationalEnzyme
DB00951IsoniazidSmall Molecule54-85-3Approved|InvestigationalEnzyme
DB00967DesloratadineSmall Molecule100643-71-8Approved|InvestigationalEnzyme
DB00969AlosetronSmall Molecule122852-42-0Approved|WithdrawnEnzyme
DB00972AzelastineSmall Molecule58581-89-8ApprovedEnzyme
DB00983FormoterolSmall Molecule73573-87-2Approved|InvestigationalEnzyme
DB00988DopamineSmall Molecule51-61-6ApprovedEnzyme
DB00991OxaprozinSmall Molecule21256-18-8ApprovedEnzyme
DB01007TioconazoleSmall Molecule65899-73-2ApprovedEnzyme
DB01009KetoprofenSmall Molecule22071-15-4ApprovedEnzyme
DB01015SulfamethoxazoleSmall Molecule723-46-6ApprovedEnzyme
DB01016GlyburideSmall Molecule10238-21-8ApprovedEnzyme
DB01018GuanfacineSmall Molecule29110-47-2Approved|InvestigationalEnzyme
DB01023FelodipineSmall Molecule72509-76-3Approved|InvestigationalEnzyme
DB01026KetoconazoleSmall Molecule65277-42-1Approved|InvestigationalEnzyme
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalEnzyme
DB01029IrbesartanSmall Molecule138402-11-6Approved|InvestigationalEnzyme
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalEnzyme
DB01036TolterodineSmall Molecule124937-51-5Approved|InvestigationalEnzyme
DB01037SelegilineSmall Molecule14611-51-9Approved|InvestigationalEnzyme
DB01039FenofibrateSmall Molecule49562-28-9ApprovedEnzyme
DB01041ThalidomideSmall Molecule50-35-1Approved|Investigational|WithdrawnEnzyme
DB01045RifampicinSmall Molecule13292-46-1ApprovedEnzyme
DB01050IbuprofenSmall Molecule15687-27-1ApprovedEnzyme
DB01065MelatoninSmall Molecule73-31-4Approved|NutraceuticalEnzyme
DB01067GlipizideSmall Molecule29094-61-9Approved|InvestigationalEnzyme
DB01069PromethazineSmall Molecule60-87-7Approved|InvestigationalEnzyme
DB01072AtazanavirSmall Molecule198904-31-3Approved|InvestigationalEnzyme
DB01075DiphenhydramineSmall Molecule58-73-1Approved|InvestigationalEnzyme
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedEnzyme
DB01079TegaserodSmall Molecule145158-71-0Approved|Investigational|WithdrawnEnzyme
DB01095FluvastatinSmall Molecule93957-54-1ApprovedEnzyme
DB01097LeflunomideSmall Molecule75706-12-6Approved|InvestigationalEnzyme
DB01098RosuvastatinSmall Molecule287714-41-4ApprovedEnzyme
DB01101CapecitabineSmall Molecule154361-50-9Approved|InvestigationalEnzyme
DB01104SertralineSmall Molecule79617-96-2ApprovedEnzyme
DB01110MiconazoleSmall Molecule22916-47-8Approved|InvestigationalEnzyme
DB01115NifedipineSmall Molecule21829-25-4ApprovedEnzyme
DB01117AtovaquoneSmall Molecule95233-18-4ApprovedEnzyme
DB01118AmiodaroneSmall Molecule1951-25-3Approved|InvestigationalEnzyme
DB01120GliclazideSmall Molecule21187-98-4ApprovedEnzyme
DB01124TolbutamideSmall Molecule64-77-7Approved|InvestigationalEnzyme
DB01128BicalutamideSmall Molecule90357-06-5ApprovedEnzyme
DB01129RabeprazoleSmall Molecule117976-89-3Approved|InvestigationalEnzyme
DB01131ProguanilSmall Molecule500-92-5ApprovedEnzyme
DB01132PioglitazoneSmall Molecule111025-46-8Approved|InvestigationalEnzyme
DB01136CarvedilolSmall Molecule72956-09-3Approved|InvestigationalEnzyme
DB01138SulfinpyrazoneSmall Molecule57-96-5ApprovedEnzyme
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalEnzyme
DB01144DiclofenamideSmall Molecule120-97-8Approved|InvestigationalEnzyme
DB01154ThiamylalSmall Molecule77-27-0ApprovedEnzyme
DB01156BupropionSmall Molecule34911-55-2ApprovedEnzyme
DB01159HalothaneSmall Molecule151-67-7ApprovedEnzyme
DB01171MoclobemideSmall Molecule71320-77-9Approved|InvestigationalEnzyme
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalEnzyme
DB01176CyclizineSmall Molecule82-92-8ApprovedEnzyme
DB01177IdarubicinSmall Molecule58957-92-9ApprovedEnzyme
DB01181IfosfamideSmall Molecule3778-73-2ApprovedEnzyme
DB01182PropafenoneSmall Molecule54063-53-5ApprovedEnzyme
DB01191DexfenfluramineSmall Molecule3239-44-9Approved|Illicit|Investigational|WithdrawnEnzyme
DB01195FlecainideSmall Molecule54143-55-4Approved|WithdrawnEnzyme
DB01198ZopicloneSmall Molecule43200-80-2ApprovedEnzyme
DB01201RifapentineSmall Molecule61379-65-5Approved|InvestigationalEnzyme
DB01217AnastrozoleSmall Molecule120511-73-1Approved|InvestigationalEnzyme
DB01221KetamineSmall Molecule6740-88-1ApprovedEnzyme
DB01229PaclitaxelSmall Molecule33069-62-4ApprovedEnzyme
DB01232SaquinavirSmall Molecule127779-20-8Approved|InvestigationalEnzyme
DB01234DexamethasoneSmall Molecule50-02-2Approved|InvestigationalEnzyme
DB01240EpoprostenolSmall Molecule35121-78-9ApprovedEnzyme
DB01241GemfibrozilSmall Molecule25812-30-0ApprovedEnzyme
DB01274ArformoterolSmall Molecule67346-49-0Approved|InvestigationalEnzyme
DB01283LumiracoxibSmall Molecule220991-20-8Approved|InvestigationalEnzyme
DB01320FosphenytoinSmall Molecule93390-81-9Approved|InvestigationalEnzyme
DB01355HexobarbitalSmall Molecule56-29-1ApprovedEnzyme
DB01357MestranolSmall Molecule72-33-3ApprovedEnzyme
DB01381Ginkgo bilobaSmall Molecule-Approved|Investigational|NutraceuticalEnzyme
DB01394ColchicineSmall Molecule64-86-8ApprovedEnzyme
DB01411PranlukastSmall Molecule103177-37-3Approved|InvestigationalEnzyme
DB01418AcenocoumarolSmall Molecule152-72-7Approved|InvestigationalEnzyme
DB01424AminophenazoneSmall Molecule58-15-1Approved|WithdrawnEnzyme
DB01435AntipyrineSmall Molecule60-80-0Approved|InvestigationalEnzyme
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitEnzyme
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitEnzyme
DB01601LopinavirSmall Molecule192725-17-0ApprovedEnzyme
DB01628EtoricoxibSmall Molecule202409-33-4Approved|InvestigationalEnzyme
DB01685TopiroxostatSmall Molecule577778-58-6Approved|InvestigationalEnzyme
DB01698RutinSmall Molecule153-18-4Experimental|InvestigationalEnzyme
DB025074-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-OneSmall MoleculeExperimentalEnzyme
DB03756DoconexentSmall Molecule6217-54-5Approved|InvestigationalEnzyme
DB03783PhenacetinSmall Molecule62-44-2WithdrawnEnzyme
DB04557Arachidonic AcidSmall Molecule506-32-1ExperimentalEnzyme
DB04574Estrone sulfateSmall Molecule481-97-0ApprovedEnzyme
DB04725LicofeloneSmall Molecule156897-06-2InvestigationalEnzyme
DB04831TicrynafenSmall Molecule40180-04-9WithdrawnEnzyme
DB04841FlunarizineSmall Molecule52468-60-7ApprovedEnzyme
DB04856DexloxiglumideSmall Molecule119817-90-2InvestigationalEnzyme
DB04868NilotinibSmall Molecule641571-10-0Approved|InvestigationalEnzyme
DB04898XimelagatranSmall Molecule192939-46-1Approved|Investigational|WithdrawnEnzyme
DB04920ClevidipineSmall Molecule167221-71-8Approved|InvestigationalEnzyme
DB04938OspemifeneSmall Molecule128607-22-7Approved|InvestigationalEnzyme
DB05015BelinostatSmall Molecule866323-14-0Approved|InvestigationalEnzyme
DB05109TrabectedinSmall Molecule114899-77-3Approved|InvestigationalEnzyme
DB05219CrisaboroleSmall Molecule906673-24-3Approved|InvestigationalEnzyme
DB05381HistamineSmall Molecule51-45-6Approved|InvestigationalEnzyme
DB05541BrivaracetamSmall Molecule357336-20-0Approved|InvestigationalEnzyme
DB05812AbirateroneSmall Molecule154229-19-3ApprovedEnzyme
DB06150SulfadimethoxineSmall Molecule122-11-2ApprovedEnzyme
DB06174NoscapineSmall Molecule128-62-1InvestigationalEnzyme
DB06204TapentadolSmall Molecule175591-23-8ApprovedEnzyme
DB06209PrasugrelSmall Molecule150322-43-3ApprovedEnzyme
DB06268SitaxentanSmall Molecule184036-34-8Approved|Investigational|WithdrawnEnzyme
DB06292DapagliflozinSmall Molecule461432-26-8ApprovedEnzyme
DB06370IndisulamSmall Molecule165668-41-7InvestigationalEnzyme
DB06413ArmodafinilSmall Molecule112111-43-0Approved|InvestigationalEnzyme
DB06414EtravirineSmall Molecule269055-15-4ApprovedEnzyme
DB06442AvasimibeSmall Molecule166518-60-1InvestigationalEnzyme
DB06594AgomelatineSmall Molecule138112-76-2Approved|InvestigationalEnzyme
DB06595MidostaurinSmall Molecule120685-11-2Approved|InvestigationalEnzyme
DB06605ApixabanSmall Molecule503612-47-3ApprovedEnzyme
DB06652VicrivirocSmall Molecule306296-47-9InvestigationalEnzyme
DB06697ArtemetherSmall Molecule71963-77-4ApprovedEnzyme
DB06712NilvadipineSmall Molecule75530-68-6Approved|InvestigationalEnzyme
DB06725LornoxicamSmall Molecule70374-39-9Approved|InvestigationalEnzyme
DB06729SulfaphenazoleSmall Molecule526-08-9ApprovedEnzyme
DB06736AceclofenacSmall Molecule89796-99-6Approved|InvestigationalEnzyme
DB06737ZaltoprofenSmall Molecule74711-43-6Approved|InvestigationalEnzyme
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalEnzyme
DB06739SeratrodastSmall Molecule112665-43-7ApprovedEnzyme
DB06741GavestinelSmall Molecule153436-22-7InvestigationalEnzyme
DB06803NiclosamideSmall Molecule50-65-7Approved|InvestigationalEnzyme
DB06820SulconazoleSmall Molecule61318-90-9ApprovedEnzyme
DB08439ParecoxibSmall Molecule198470-84-7ApprovedEnzyme
DB08798SulfamoxoleSmall Molecule729-99-7ApprovedEnzyme
DB08816TicagrelorSmall Molecule274693-27-5ApprovedEnzyme
DB08828VismodegibSmall Molecule879085-55-9Approved|InvestigationalEnzyme
DB08860PitavastatinSmall Molecule147511-69-1ApprovedEnzyme
DB08875CabozantinibSmall Molecule849217-68-1Approved|InvestigationalEnzyme
DB08896RegorafenibSmall Molecule755037-03-7ApprovedEnzyme
DB08899EnzalutamideSmall Molecule915087-33-1ApprovedEnzyme
DB09048NetupitantSmall Molecule290297-26-6Approved|InvestigationalEnzyme
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
DB09063CeritinibSmall Molecule1032900-25-6ApprovedEnzyme
DB09068VortioxetineSmall Molecule508233-74-7Approved|InvestigationalEnzyme
DB09080OlodaterolSmall Molecule868049-49-4ApprovedEnzyme
DB09118StiripentolSmall Molecule49763-96-4ApprovedEnzyme
DB09120ZucapsaicinSmall Molecule25775-90-0Approved|InvestigationalEnzyme
DB09167DosulepinSmall Molecule113-53-1ApprovedEnzyme
DB09198LobeglitazoneSmall Molecule607723-33-1Approved|InvestigationalEnzyme
DB09238ManidipineSmall Molecule89226-50-6Approved|InvestigationalEnzyme
DB09280LumacaftorSmall Molecule936727-05-8ApprovedEnzyme
DB09396Propoxyphene napsylateSmall MoleculeApprovedEnzyme
DB09570IxazomibSmall Molecule1072833-77-2Approved|InvestigationalEnzyme
DB11560LesinuradSmall Molecule878672-00-5Approved|InvestigationalEnzyme
DB11611LifitegrastSmall Molecule1025967-78-5ApprovedEnzyme
DB11614RupatadineSmall Molecule158876-82-5ApprovedEnzyme
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalEnzyme
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalEnzyme
DB11943DelafloxacinSmall Molecule189279-58-1Approved|InvestigationalEnzyme
DB12070LetermovirSmall Molecule917389-32-3Approved|InvestigationalEnzyme
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalEnzyme
DB13174RheinSmall Molecule478-43-3ExperimentalEnzyme
DB13179TroleandomycinSmall Molecule2751-09-9ApprovedEnzyme
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalEnzyme
DB13919CandesartanSmall Molecule139481-59-7ExperimentalEnzyme
DB13941PiperaquineSmall Molecule4085-31-8Approved|InvestigationalEnzyme
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedEnzyme
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedEnzyme
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalEnzyme
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalEnzyme
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalEnzyme
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalEnzyme
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalEnzyme
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C06571910-hydroxywarfarin10-hydroxywarfarin binds to and results in decreased activity of CYP2C9 protein20429590
C06571910-hydroxywarfarin[10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA20735727
C06571910-hydroxywarfarin10-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C04678311,12-epoxy-5,8,14-eicosatrienoic acid"CYP2C9 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid"12675279
C04678311,12-epoxy-5,8,14-eicosatrienoic acid"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]"12675279
C4956571,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane"CYP2C9 protein results in increased chemical synthesis of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane"9733665
C0264861,2,5,6-dibenzanthracene"CYP2C9 protein results in increased metabolism of 1,2,5,6-dibenzanthracene"8638931
C0264861,2,5,6-dibenzanthracene"[CYP2C9 protein results in increased metabolism of 1,2,5,6-dibenzanthracene] which results in increased chemical synthesis of dibenzoanthracene-3,4-dihydrodiol"8638931
C51721412-hydroxyellipticineCYP2C9 protein mutant form results in increased chemical synthesis of 12-hydroxyellipticine22917556
C4393921-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline"CYP2C9 protein results in decreased methylation of 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline"15585365
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidKetoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidQuercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidThioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidTranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C51721513-hydroxyellipticineCYP2C9 protein mutant form results in increased chemical synthesis of 13-hydroxyellipticine22917556
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid"12675279
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]"12675279
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[Anisomycin co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2C9 mRNA"23539296
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene results in increased activity of CYP2C9 protein"29285606
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"CYP2C9 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"[CYP2C9 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene metabolite"29285606
C0353421,4-naphthoquinone"CYP2C9 protein results in increased abundance of 1,4-naphthoquinone"16243959
C5587371-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea"1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea affects the activity of CYP2C9 protein"21341682
C48613616-O-demethylaconitine[Amiodarone results in decreased activity of CYP2C9 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine21277363
C48613616-O-demethylaconitine[CYP2C9 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine21277363
C0330201-aminobenzotriazole1-aminobenzotriazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15618748
C0293501-naphtholCYP2C9 protein results in increased abundance of 1-naphthol16243959
C0243361-phenylazo-2-naphtholCYP2C9 protein results in increased oxidation of 1-phenylazo-2-naphthol17159775
C0839982-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-aCYP2C9 protein results in increased abundance of 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a11668218
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]24830941
C0514502-ethyl-5-carboxypentyl phthalate[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of 2-ethyl-5-carboxypentyl phthalate23545481
C5865422'-(glutathion-S-yl)-deschlorodiclofenac[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac24246759
C0053282-nitroanisoleCYP2C9 protein results in increased oxidation of 2-nitroanisole21218109
C5409042-oxo-clopidogrelCYP2C9 protein results in increased oxidation of 2-oxo-clopidogrel19812348
C5409042-oxo-clopidogrelSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased oxidation of 2-oxo-clopidogrel]19812348
C0450222-propyl-4-pentenoic acidCYP2C9 protein results in increased chemical synthesis of 2-propyl-4-pentenoic acid16945988
C0188552-tert-butylhydroquinone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]24830941
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone promotes the reaction [FOS protein binds to CYP2C9 promoter]24830941
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone promotes the reaction [JUND protein binds to CYP2C9 promoter]24830941
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone promotes the reaction [JUND protein modified form binds to CYP2C9 promoter]24830941
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA24830941
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of CYP2C9 protein24830941
C0188552-tert-butylhydroquinoneJUND mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]24830941
C0188552-tert-butylhydroquinonepyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]24830941
C1096023-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate"3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate results in decreased activity of CYP2C9 protein"16049129
C1096023-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate"CYP2C9 protein affects the metabolism of 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate"16049129
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]"21053930
C0414773-hydroxyflavone3-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C0087454,4'-bisphenol F"CYP2C9 protein results in increased glutathionylation of 4,4'-bisphenol F"23470418
C0087454,4'-bisphenol F"CYP2C9 protein results in increased glutathionylation of 4,4'-bisphenol F metabolite"23470418
C0087454,4'-bisphenol F"CYP2C9 protein results in increased hydroxylation of 4,4'-bisphenol F"23470418
C4385834-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"CYP2C9 protein affects the metabolism of 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"16012074
C4385834-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"CYP2C9 protein results in decreased ethylation of 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"16012074
C5701064,4'-cyclohexylidenebisphenol"CYP2C9 protein results in increased glutathionylation of 4,4'-cyclohexylidenebisphenol"23470418
C5701064,4'-cyclohexylidenebisphenol"CYP2C9 protein results in increased glutathionylation of 4,4'-cyclohexylidenebisphenol metabolite"23470418
C5701064,4'-cyclohexylidenebisphenol"CYP2C9 protein results in increased hydroxylation of 4,4'-cyclohexylidenebisphenol"23470418
C5830744,4'-hexafluorisopropylidene diphenol"CYP2C9 protein results in increased hydroxylation of 4,4'-hexafluorisopropylidene diphenol"23470418
C5458804,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide"CYP2C9 protein results in increased metabolism of and results in increased activity of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide"19697924
C5458804,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide"[CYP2C9 protein results in increased metabolism of and results in increased activity of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide] which results in increased chemical synthesis of chlorophenyl isocyanate"19697924
C5458804,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]"19697924
C0123584-hydroxycyclophosphamideCYP2C9 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide24819615
C1080364'-hydroxydiclofenac[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac24246759
C1080364'-hydroxydiclofenac[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac24246759
C1080364'-hydroxydiclofenacCYP2C9 protein results in increased chemical synthesis of 4'-hydroxydiclofenac12401345|1515555
C1080364'-hydroxydiclofenac[CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac24104198
C1080364'-hydroxydiclofenac[CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac25084468
C1080364'-hydroxydiclofenacSulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]24246759
C1080364'-hydroxydiclofenacCYP2C9 protein results in increased abundance of 4'-hydroxydiclofenac27130197
C1080364'-hydroxydiclofenacCYP2C9 protein results in increased metabolism of 4'-hydroxydiclofenac27130197
C1080364'-hydroxydiclofenac[CYP2C9 protein results in increased oxidation of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac24552538
C0554924-hydroxy-N-desmethyltamoxifen4-hydroxy-N-desmethyltamoxifen results in decreased activity of CYP2C9 protein29285606
C0194294-hydroxyretinoic acidCYP2C9 protein results in increased chemical synthesis of 4-hydroxyretinoic acid10874126
C0912074-hydroxyvalproateCYP2C9 protein results in increased chemical synthesis of 4-hydroxyvalproate16945988
C0598534'-hydroxywarfarin4'-hydroxywarfarin binds to and results in decreased activity of CYP2C9 protein20429590
C0598534'-hydroxywarfarin[4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA20735727
C0598534'-hydroxywarfarin4'-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C0286904-isopropylphenolCYP2C9 protein results in increased glutathionylation of 4-isopropylphenol23470418
C4878504'-methoxyflavone4'-methoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C0234394-methylimidazole4-methylimidazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
C0022024-oxoretinoic acidCYP2C9 protein results in increased chemical synthesis of 4-oxoretinoic acid10874126
C1052604-tert-octylphenolCYP2C9 gene SNP results in increased susceptibility to 4-tert-octylphenol23555028
C0409975-bromotryptamine5-bromotryptamine analog results in decreased activity of CYP2C9 protein26599973
C0409975-bromotryptamine[5-bromotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
C5291695-chlorotryptamine5-chlorotryptamine analog results in decreased activity of CYP2C9 protein26599973
C5291695-chlorotryptamine[5-chlorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
C0511015-fluoro-alpha-methyltryptamine5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2C9 protein26599973
C0511015-fluoro-alpha-methyltryptamine[5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
C0345365-fluorotryptamine5-fluorotryptamine analog results in decreased activity of CYP2C9 protein26599973
C0345365-fluorotryptamine[5-fluorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
C0627115-hydroxyflavone5-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C0414055-hydroxythienilic acidCYP2C9 protein results in increased chemical synthesis of 5-hydroxythienilic acid22329513
C0912085-hydroxyvalproateCYP2C9 protein results in increased chemical synthesis of 5-hydroxyvalproate16945988
C4874135-methoxyindole5-methoxyindole results in decreased activity of CYP2C9 protein18420780
C0275525-methyltryptamine5-methyltryptamine analog results in decreased activity of CYP2C9 protein26599973
C0275525-methyltryptamine[5-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
C0005889585-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid results in decreased activity of CYP2C9 protein23631744
C5478585-n-butyl-pyrazolo(1,5-a)pyrimidine"5-n-butyl-pyrazolo(1,5-a)pyrimidine metabolite binds to CYP2C9 protein"19928966
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
C4853836,7-dihydroxyflavone"6,7-dihydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]"21053930
C0080916-hydroxywarfarin6-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C0080916-hydroxywarfarin6-hydroxywarfarin results in decreased activity of CYP2C9 protein20429590
C0080916-hydroxywarfarin7-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin]20429590
C0080916-hydroxywarfarin[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin20429590
C0080916-hydroxywarfarin[CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin19408964
C1078827,8-dihydromethysticin"7,8-dihydromethysticin results in decreased activity of CYP2C9 protein"16033948
C4298457-hydroxyflavone7-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C0878377-hydroxywarfarin10-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C0878377-hydroxywarfarin4'-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C0878377-hydroxywarfarin6-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C0878377-hydroxywarfarin7-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin]20429590
C0878377-hydroxywarfarin7-hydroxywarfarin results in decreased activity of CYP2C9 protein20429590
C0878377-hydroxywarfarin8-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C0878377-hydroxywarfarinCYP2C9 gene polymorphism affects the abundance of 7-hydroxywarfarin25986145
C0878377-hydroxywarfarinCYP2C9 protein results in increased chemical synthesis of 7-hydroxywarfarin25986145
C0878377-hydroxywarfarin[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin20429590
C0878377-hydroxywarfarin[CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin19408964
C0366967-methyltryptamine7-methyltryptamine analog results in decreased activity of CYP2C9 protein26599973
C0366967-methyltryptamine[7-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
C0507158,9-epoxyeicosatrienoic acid"CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid"12675279
C0507158,9-epoxyeicosatrienoic acid"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]"12675279
C1014368-hydroxywarfarin8-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
C1014368-hydroxywarfarin8-hydroxywarfarin results in decreased activity of CYP2C9 protein20429590
C023717acacetinacacetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C042553acenaphthyleneCYP2C9 protein results in increased oxidation of acenaphthylene25642975
D000074AcenocoumarolCYP2C9 gene polymorphism affects the susceptibility to Acenocoumarol15213846|1686982
D000074AcenocoumarolCYP2C9 protein affects the metabolism of Acenocoumarol11918509
D000074AcenocoumarolCYP2C9 protein results in increased metabolism of Acenocoumarol16878445
D000074AcenocoumarolCYP2C9 protein results in increased susceptibility to Acenocoumarol16869821
D000082AcetaminophenAcetaminophen results in decreased expression of CYP2C9 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of CYP2C9 mRNA22230336
D000096AcetoneAcetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]10611138
C032159acetonitrileacetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]10611138
D000157Aconitine[Amiodarone results in decreased activity of CYP2C9 protein] which results in decreased chemical synthesis of Aconitine metabolite21277363
D000157AconitineCYP2C9 protein results in increased metabolism of Aconitine21277363
D000157Aconitine[CYP2C9 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine21277363
C053001adefoviradefovir results in decreased activity of CYP2C9 protein17162464
C106812adefovir dipivoxiladefovir dipivoxil results in decreased activity of CYP2C9 protein17162464
C016601afimoxifeneCYP2C9 protein results in increased metabolism of afimoxifene29285606
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYP2C9 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP2C9 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CYP2C9 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYP2C9 mRNA21994236
D016604Aflatoxin B1[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B123397584
C090840alosetronCYP2C9 affects the metabolism of alosetron11304902|1130490
D017962alpha-Linolenic Acidalpha-Linolenic Acid results in decreased activity of CYP2C9 protein16978661
D017962alpha-Linolenic AcidCYP2C9 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP]16978661
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D000638AmiodaroneAmiodarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D000638AmiodaroneAmiodarone promotes the reaction [CYP2C9 protein affects the metabolism of Naproxen]16081671
D000638AmiodaroneAmiodarone promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D000638AmiodaroneAmiodarone results in decreased activity of CYP2C9 protein16449812
D000638Amiodarone[Amiodarone results in decreased activity of CYP2C9 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine21277363
D000638Amiodarone[Amiodarone results in decreased activity of CYP2C9 protein] which results in decreased chemical synthesis of Aconitine metabolite21277363
D000638AmiodaroneCYP2C9 protein results in decreased susceptibility to Amiodarone26477383
D000638AmiodaroneAmiodarone affects the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
D000639Amitriptyline[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline23397584
D000655AmodiaquineAmodiaquine results in decreased activity of CYP2C9 protein11124226
D000894Anti-Inflammatory Agents, Non-Steroidal"CYP2C9 gene polymorphism affects the susceptibility to Anti-Inflammatory Agents, Non-Steroidal"19715737
D000894Anti-Inflammatory Agents, Non-Steroidal"CYP2C9 protein results in increased metabolism of Anti-Inflammatory Agents, Non-Steroidal"19715737
D000894Anti-Inflammatory Agents, Non-Steroidal"Anti-Inflammatory Agents, Non-Steroidal results in increased expression of CYP2C9"19445531
C030419andrographolideandrographolide results in decreased expression of CYP2C9 mRNA19041297
D000841Anisomycin"[Anisomycin co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2C9 mRNA"23539296
D000925AnticoagulantsCYP2C9 gene polymorphism affects the susceptibility to Anticoagulants19715737
D047310ApigeninApigenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C004984apocarotenalapocarotenal results in increased expression of CYP2C9 mRNA17034753
D016718Arachidonic AcidArachidonic Acid results in decreased activity of CYP2C9 protein16978661
D016718Arachidonic AcidCYP2C9 protein results in increased metabolism of Arachidonic Acid12675279
D016718Arachidonic AcidCYP2C9 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]16978661
D016718Arachidonic AcidSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Arachidonic Acid]12675279
D001140AroclorsAroclors results in increased expression of CYP2C9 protein29162470
D001241AspirinCYP2C9 polymorphism affects the susceptibility to Aspirin21966608
C423185avasimibeavasimibe results in decreased activity of CYP2C9 protein15333513
C423185avasimibeavasimibe results in increased activity of and results in increased expression of CYP2C9 protein19202563
C423185avasimibeavasimibe results in increased expression of and results in increased activity of CYP2C9 protein15333513
C006680baicaleinbaicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C447119bazedoxifeneCYP2C9 protein results in increased glutathionylation of bazedoxifene22429462
C096128benfuracarbCYP2C9 protein results in increased oxidation of benfuracarb24016712
C061004benidipinebenidipine results in decreased activity of CYP2C9 protein10805063|2773288
D001553BenzbromaroneBenzbromarone analog binds to and results in decreased activity of CYP2C9 protein12814975|1517033
D001553BenzbromaroneBenzbromarone binds to and results in decreased activity of CYP2C9 protein15170332
D001553BenzbromaroneBenzbromarone binds to CYP2C9 protein12814975
D001553BenzbromaroneBenzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D001553BenzbromaroneBenzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Warfarin]10613612
D001553BenzbromaroneBenzbromarone inhibits the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]15955872
D001553BenzbromaroneBenzbromarone promotes the reaction [CYP2C9 protein affects the metabolism of Naproxen]16081671
D001553BenzbromaroneBenzbromarone promotes the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]15955872
D001553BenzbromaroneCYP2C9 protein affects the metabolism of Benzbromarone18020424|2132106
D001553BenzbromaroneBenzbromarone affects the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
D001553BenzbromaroneBenzbromarone analog affects the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
D001553BenzbromaroneBenzbromarone analog binds to and results in decreased activity of CYP2C9 protein18255300
D001553BenzbromaroneCYP2C9 protein results in increased metabolism of Benzbromarone21449597
D019324beta-Naphthoflavonebeta-Naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of CYP2C9 mRNA16985168
D003374CoumarinsAmiodarone promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D003374CoumarinsCYP2C9 protein results in increased metabolism of Coumarins14557374
D003374CoumarinsDichlorphenamide promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D003374Coumarinsestropipate promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D003374CoumarinsNiclosamide promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D003374CoumarinsTriiodothyronine promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D019207beta Carotenebeta Carotene results in increased expression of CYP2C9 mRNA17034753
D004958Estradiol[ESR1 protein co-treated with MED25 protein co-treated with Estradiol] results in increased activity of CYP2C9 protein27273787
D004958Estradiol[ESR1 protein co-treated with MED25 protein co-treated with Estradiol] results in increased expression of CYP2C9 mRNA27273787
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
D004958EstradiolEstradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
D004958EstradiolEstradiol results in increased activity of CYP2C9 protein22837389
D004958Estradiol"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]]"21768169
D004958EstradiolNR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]]21768169
D004958Estradiol"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D004958Estradiol"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
D004958Estradiol[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
D001663BilirubinBilirubin results in increased expression of CYP2C9 mRNA15382119
D001663BilirubinIL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA]15382119
C004541biochanin Abiochanin A results in decreased activity of CYP2C9 protein26278343
C543008bis(4-hydroxyphenyl)sulfoneCYP2C9 protein results in increased hydroxylation of bis(4-hydroxyphenyl)sulfone27213244
C006780bisphenol Abisphenol A results in increased expression of CYP2C9 mRNA26196221
C006780bisphenol ACYP2C9 protein results in increased glutathionylation of bisphenol A23470418
C006780bisphenol ACYP2C9 protein results in increased glutathionylation of bisphenol A metabolite23470418
C006780bisphenol ACYP2C9 protein results in increased hydroxylation of bisphenol A23470418
C006780bisphenol ACYP2C9 protein results in increased hydroxylation of bisphenol A metabolite23470418
C006780bisphenol A[ESR1 protein co-treated with MED25 protein co-treated with bisphenol A] results in increased activity of CYP2C9 protein27273787
C006780bisphenol A[ESR1 protein co-treated with MED25 protein co-treated with bisphenol A] results in increased expression of CYP2C9 mRNA27273787
C006780bisphenol Abisphenol A results in decreased expression of CYP2C9 mRNA25181051
D000069286BortezomibCYP2C9 protein affects the metabolism of Bortezomib15764713
C086232bosentanbosentan results in increased expression of CYP2C916550733
C010831bufuralolCYP2C9 protein results in increased hydroxylation of bufuralol9429232
D002066Busulfan[GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]28744217
C018475butyraldehydebutyraldehyde results in increased expression of CYP2C9 mRNA26079696
D002104CadmiumCadmium results in increased expression of CYP2C9 protein11551516
D002110CaffeineCaffeine results in decreased activity of CYP2C9 protein18420780
D002185CannabidiolCannabidiol results in decreased activity of CYP2C9 protein24667653
D002211CapsaicinCapsaicin results in decreased activity of CYP2C9 protein22375877
D002220CarbamazepineCarbamazepine results in increased activity of CYP2C9 protein19202563
D002220CarbamazepineCarbamazepine results in increased expression of CYP2C9 mRNA17112801
D002220Carbamazepine[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Carbamazepine23397584
D002220CarbamazepineCYP2C9 protein affects the metabolism of Carbamazepine15286053
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of CYP2C9 protein16288784
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein]16288784
D000068579CelecoxibCYP2C9 protein results in increased metabolism of Celecoxib17681167|1908287
C088453CelsiorCelsior results in decreased activity of CYP2C9 protein15448115
C088453CelsiorCelsior results in decreased expression of CYP2C9 mRNA15448115
C452229chlorophenyl isocyanate"[CYP2C9 protein results in increased metabolism of and results in increased activity of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide] which results in increased chemical synthesis of chlorophenyl isocyanate"19697924
D002746ChlorpromazineChlorpromazine results in decreased activity of CYP2C9 protein15135088
D002746Chlorpromazine[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine23397584
D002746ChlorpromazineCYP2C9 protein results in decreased susceptibility to Chlorpromazine26477383
D004390ChlorpyrifosCYP2C9 protein affects the metabolism of Chlorpyrifos16190164
D002784CholesterolCholesterol results in decreased activity of CYP2C9 protein18420780
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CYP2C9 mRNA27344345
C043561chrysinchrysin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C027113chrysophanic acidchrysophanic acid results in decreased activity of CYP2C9 protein27633141
D002927CimetidineCimetidine results in decreased activity of CYP2C9 protein19909766
D002927Cimetidinestyrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2C9 protein]19909766
C029010cinnamic acidcinnamic acid analog results in decreased activity of CYP2C9 protein15072549
D020117CisaprideCisapride results in decreased activity of CYP2C9 protein15306208
D002995Clofibric AcidClofibric Acid results in increased expression of CYP2C9 mRNA15802389
C055162clopidogrelCYP2C9 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]19926050|1993479
C055162clopidogrelCYP2C9 gene SNP affects the susceptibility to clopidogrel17900275
C055162clopidogrelCYP2C9 gene SNP results in decreased metabolism of clopidogrel17900275
C055162clopidogrelCYP2C9 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite19170597
D003022ClotrimazoleClotrimazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D003022ClotrimazoleClotrimazole results in increased activity of and results in increased expression of CYP2C9 protein19202563
D003024Clozapine[Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin17961958
D003024Clozapine[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine23397584
D003024ClozapineCYP2C9 protein results in increased metabolism of Clozapine18809730
D003042CocaineCocaine results in decreased expression of CYP2C9 mRNA16188404
D003042CocaineCocaine results in decreased expression of CYP2C9 protein16188404
D009249NADPCYP2C9 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP]16978661
D009249NADPCYP2C9 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]16978661
D009249NADPCYP2C9 protein results in increased metabolism of [Docosahexaenoic Acids co-treated with NADP]16978661
D009249NADPCYP2C9 protein results in increased metabolism of [Eicosapentaenoic Acid co-treated with NADP]16978661
D009249NADPCYP2C9 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]16978661
D009249NADPKetoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D009249NADP[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid24120545
D009249NADPQuercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D009249NADPThioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D009249NADPTranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D003300Copper[CYP2C9 protein co-treated with Copper] results in increased activity of Eugenol15576237
C030123coumarinCYP2C9 protein polymorphism affects the metabolism of coumarin17849045
C030123coumarinCYP2C9 protein polymorphism affects the susceptibility to coumarin23582453
C007164cumene hydroperoxideCYP2C9 protein affects the oxidation of cumene hydroperoxide17478480
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein]16288784
D003505CyclodextrinsCyclodextrins analog results in increased activity of CYP2C9 protein15665498
D053138CyclohexenesCyclohexenes analog inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]20452209
D003520CyclophosphamideCYP2C9 protein results in increased metabolism of Cyclophosphamide11377097|2481961
D003520CyclophosphamideCYP2C9 protein results in increased susceptibility to Cyclophosphamide10991840
D003520CyclophosphamideCYP2C9 results in increased activity of Cyclophosphamide9241661
D003520Cyclophosphamide[GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]28744217
D003520CyclophosphamideSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased susceptibility to Cyclophosphamide]10991840
D003520CyclophosphamideCyclophosphamide results in decreased activity of CYP2C9 protein18420780
D003520CyclophosphamideCYP2C9 affects the activity of Cyclophosphamide16475710
D016572CyclosporineCyclosporine results in decreased expression of CYP2C9 mRNA20106945|2798913
C017160cypermethrincypermethrin results in decreased activity of CYP2C9 protein18420780
C017160cypermethrincypermethrin results in increased expression of CYP2C9 mRNA22310298
C093628cyproconazolecyproconazole results in decreased activity of CYP2C9 protein21251949
C004742daidzeindaidzein results in decreased activity of CYP2C9 protein18420780
D003622DapsoneCYP2C9 protein affects the metabolism of Dapsone12920490
D003622DapsoneDapsone promotes the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]15130760
D003622DapsoneDapsone promotes the reaction [CYP2C9 protein polymorphism results in increased hydroxylation of Flurbiprofen]15130760
D003622DapsoneDapsone promotes the reaction [CYP2C9 protein results in decreased methylation of Naproxen]15130760
D003622DapsoneDapsone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]15130760
D003622DapsoneDapsone results in decreased activity of CYP2C9 protein11124226
C017180decamethrindecamethrin results in increased expression of CYP2C9 mRNA22310298
D003671DEETDEET results in increased expression of CYP2C9 mRNA27091632
D003671DEET[fipronil co-treated with DEET] results in increased expression of CYP2C9 mRNA27091632
D020008DelavirdineDelavirdine results in decreased activity of CYP2C9 protein11225565
D013759DronabinolCYP2C9 polymorphism affects the susceptibility to Dronabinol19005461
C036116desethylamiodaronedesethylamiodarone inhibits the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
C047386desethylamodiaquineCYP2C9 protein results in increased metabolism of desethylamodiaquine28478157
C047386desethylamodiaquinedesethylamodiaquine results in decreased activity of CYP2C9 protein11124226
D003891DesipramineDesipramine results in decreased activity of CYP2C9 protein15135088
D003907DexamethasoneDexamethasone results in increased activity of CYP2C9 protein19202563
D003907DexamethasoneDexamethasone results in increased expression of and results in increased activity of CYP2C9 protein15802389
D003907DexamethasoneDexamethasone results in increased expression of CYP2C9 mRNA15802389
D036381DiarylheptanoidsDiarylheptanoids results in decreased activity of CYP2C9 protein23850985
D003976DiazinonCYP2C9 protein results in increased metabolism of and results in increased activity of Diazinon11708902
C018912dibenzoanthracene-3,4-dihydrodiol"[CYP2C9 protein results in increased metabolism of 1,2,5,6-dibenzanthracene] which results in increased chemical synthesis of dibenzoanthracene-3,4-dihydrodiol"8638931
C558664dibenzylfluoresceinCYP2C9 protein results in increased metabolism of dibenzylfluorescein23850985
C558664dibenzylfluorescein[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein23850985
C558664dibenzylfluoresceinSulfaphenazole inhibits the reaction [[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]23850985
D002945CisplatinCYP2C9 protein affects the susceptibility to Cisplatin16217747
D004005DichlorphenamideDichlorphenamide promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D004008DiclofenacCYP2C9 protein affects the metabolism of Diclofenac15801540
D004008DiclofenacDiclofenac inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D004008Diclofenac1-aminobenzotriazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15618748
D004008Diclofenac4-methylimidazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008Diclofenac[5-bromotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008Diclofenac[5-chlorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008Diclofenac[5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008Diclofenac[5-fluorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008Diclofenac[5-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008Diclofenac[7-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008DiclofenacAmiodarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacBenzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacClotrimazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacCyclohexenes analog inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]20452209
D004008Diclofenac[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac23397584
D004008Diclofenac[CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac15486075
D004008DiclofenacCYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]25994031|2599403
D004008DiclofenacCYP2C9 gene polymorphism affects the hydrolysis of Diclofenac9698079
D004008DiclofenacCYP2C9 gene polymorphism results in decreased hydroxylation of Diclofenac11455026
D004008DiclofenacCYP2C9 protein affects the metabolism of Diclofenac15801540|1608167
D004008DiclofenacCYP2C9 protein binds to Diclofenac15039296
D004008Diclofenac[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac24246759
D004008Diclofenac[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac24246759
D004008Diclofenac[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac24246759
D004008DiclofenacCYP2C9 protein results in increased hydrolysis of Diclofenac9698079
D004008DiclofenacCYP2C9 protein results in increased hydroxylation of and results in increased susceptibility to Diclofenac28762043
D004008DiclofenacCYP2C9 protein results in increased hydroxylation of Diclofenac10975605|1099184
D004008DiclofenacCYP2C9 protein results in increased metabolism of Diclofenac12401345|1246424
D004008Diclofenac[CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac24104198
D004008Diclofenac[CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac25084468
D004008DiclofenacCYP2C9 protein results in increased oxidation of Diclofenac17478480
D004008Diclofenac[CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac28762043
D004008Diclofenac[CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac28762043
D004008DiclofenacDiclofenac results in decreased activity of CYP2C9 protein15135088
D004008DiclofenacDiclofenac results in increased activity of CYP2C9 protein15802386
D004008DiclofenacFluconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008Diclofenac[Fluconazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008Diclofenacfluvastatin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacIbuprofen inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacKetoconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacLansoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
D004008DiclofenacMiconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacOmeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
D004008Diclofenacpantoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
D004008Diclofenacperfluorooctane sulfonic acid inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]21964418
D004008DiclofenacPiroxicam inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacQuinine inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008Diclofenacrabeprazole-thioether inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
D004008DiclofenacSertraline inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008Diclofenacsitaxsentan inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]23721565
D004008DiclofenacSulfaphenazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]12569440|2811916
D004008Diclofenac[Sulfaphenazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac22447115|2659997
D004008DiclofenacSulfinpyrazone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacTicrynafen inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]16049126
D004008DiclofenacTolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008Diclofenac[Tryptamines analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D004008DiclofenacWarfarin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008Diclofenaczafirlukast inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D004008DiclofenacDiclofenac results in decreased activity of CYP2C9 protein18420780
D004008DiclofenacCYP2C9 protein affects the metabolism of Diclofenac15801540
D004008DiclofenacCYP2C9 protein affects the hydroxylation of Diclofenac15044613
D004008DiclofenacCYP2C9 protein results in increased oxidation of Diclofenac24552538
D004008Diclofenac[CYP2C9 protein results in increased oxidation of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac24552538
C121718dicyclanildicyclanil results in increased expression of CYP2C9 mRNA15664270
D004041Dietary FatsDietary Fats results in decreased expression of CYP2C9 mRNA21852083
C012906dihydrocapsaicindihydrocapsaicin results in decreased activity of CYP2C9 protein22375877
D004087DihydroergotamineDihydroergotamine results in decreased activity of CYP2C9 protein18420780
C012621dimemorfanCYP2C9 protein results in increased oxidation of dimemorfan19593786
D0151279,10-Dimethyl-1,2-benzanthracene"CYP2C9 protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene"20507880
C039602diosmetindiosmetin results in decreased activity of CYP2C9 protein28867436
D004281Docosahexaenoic AcidsCYP2C9 protein results in increased metabolism of [Docosahexaenoic Acids co-treated with NADP]16978661
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased activity of CYP2C9 protein16978661
D004298DopamineDopamine results in decreased activity of CYP2C9 protein18420780
D004365Drugs, Chinese Herbal"[Drugs, Chinese Herbal results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA"16267138
C098320efavirenzefavirenz results in decreased activity of CYP2C9 protein11225565
D015118Eicosapentaenoic AcidCYP2C9 protein results in increased metabolism of [Eicosapentaenoic Acid co-treated with NADP]16978661
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased activity of CYP2C9 protein16978661
C034192ellipticineCYP2C9 protein mutant form results in increased metabolism of ellipticine22917556
D004642EmodinEmodin results in decreased activity of CYP2C9 protein27633141
D004917ErythromycinErythromycin results in decreased activity of CYP2C9 protein18420780
C009927estropipateestropipate promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D004997Ethinyl EstradiolCYP2C9 protein results in increased hydroxylation of Ethinyl Estradiol15304426
D005054Eugenol[CYP2C9 protein co-treated with Copper] results in increased activity of Eugenol15576237
D015736FelodipineFelodipine results in decreased activity of CYP2C9 protein27732883
D005278FenitrothionFenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
D005278FenitrothionFenitrothion results in decreased activity of CYP2C9 protein20183062|2263405
C017690fenvaleratefenvalerate results in increased expression of CYP2C9 mRNA22310298
C082360fipronil[fipronil co-treated with DEET] results in increased expression of CYP2C9 mRNA27091632
C082360fipronilfipronil results in increased expression of CYP2C9 mRNA27091632
C028610flavanoneflavanone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C043562flavoneflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D015725FluconazoleFluconazole affects the reaction [CYP2C9 gene polymorphism affects the metabolism of Flurbiprofen]18378563
D015725FluconazoleFluconazole binds to and results in decreased activity of CYP2C9 protein28887089
D015725FluconazoleFluconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D015725FluconazoleFluconazole results in decreased activity of CYP2C9 protein15328084|1584349
D015725Fluconazole[Fluconazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D015725FluconazoleFluconazole results in decreased activity of CYP2C9 protein16556082|1758025
D019793Fluorescein[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein23850985
D019793FluoresceinSulfaphenazole inhibits the reaction [[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]23850985
D005473FluoxetineCYP2C9 gene polymorphism affects the abundance of Fluoxetine14726986
D005473FluoxetineCYP2C9 protein affects the abundance of Fluoxetine15094477
D005473FluoxetineCYP2C9 protein results in increased metabolism of Fluoxetine14726986
D005473FluoxetineCYP2C9 affects the metabolism of Fluoxetine11304903
D005473Fluoxetine[CYP2C9 affects the metabolism of Fluoxetine] which results in increased chemical synthesis of norfluoxetine11304903
D005476FluphenazineFluphenazine results in decreased activity of CYP2C9 protein15135088
D005480FlurbiprofenFlurbiprofen inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D005480Flurbiprofen"3',4'-dimethoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]"21053930
D005480Flurbiprofen3-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofen4'-methoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofen5-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofen"6,7-dihydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]"21053930
D005480Flurbiprofen7-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofenacacetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofenalpha-naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480FlurbiprofenApigenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofenbaicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480FlurbiprofenBenzbromarone inhibits the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]15955872
D005480FlurbiprofenBenzbromarone promotes the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]15955872
D005480Flurbiprofenbeta-Naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofenchrysin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480FlurbiprofenCYP2C9 gene polymorphism affects the hydrolysis of Flurbiprofen9698079
D005480FlurbiprofenCYP2C9 gene polymorphism affects the metabolism of Flurbiprofen11901091|1837856
D005480FlurbiprofenCYP2C9 protein affects the hydroxylation of Flurbiprofen15955872
D005480FlurbiprofenCYP2C9 protein polymorphism results in increased hydroxylation of Flurbiprofen15130760
D005480FlurbiprofenCYP2C9 protein results in increased hydrolysis of Flurbiprofen9698079
D005480FlurbiprofenCYP2C9 protein results in increased hydroxylation of Flurbiprofen15130760|2105393
D005480FlurbiprofenCYP2C9 protein results in increased metabolism of Flurbiprofen11901091|1837856
D005480FlurbiprofenDapsone promotes the reaction [CYP2C9 protein polymorphism results in increased hydroxylation of Flurbiprofen]15130760
D005480FlurbiprofenDapsone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]15130760
D005480Flurbiprofenflavanone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofenflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480FlurbiprofenFluconazole affects the reaction [CYP2C9 gene polymorphism affects the metabolism of Flurbiprofen]18378563
D005480FlurbiprofenFlurbiprofen binds to CYP2C9 protein21053930
D005480Flurbiprofengalangin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480FlurbiprofenGenistein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofenkaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofennaringenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480Flurbiprofennaringin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005480FlurbiprofenQuercetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D005485Flutamide[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide23397584
D005485FlutamideFlutamide results in increased expression of CYP2C9 mRNA24793618
C065180fluvastatinfluvastatin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
C065180fluvastatinfluvastatin results in decreased activity of CYP2C9 protein10197301
C037032galangingalangin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D015248GemfibrozilGemfibrozil results in decreased activity of CYP2C9 protein16042675
D019833GenisteinGenistein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C048393germacronegermacrone results in decreased activity of CYP2C9 protein23850985
C063170Ginkgo biloba extractGinkgo biloba extract results in decreased activity of CYP2C9 protein15147983
D005913GlipizideCYP2C9 gene polymorphism results in decreased metabolism of Glipizide10208645
D005913GlipizideCYP2C9 protein results in increased metabolism of Glipizide10208645
D005978Glutathione[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac24246759
D005978Glutathione[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac24246759
D005978Glutathione[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac24246759
D005978Glutathione[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac24246759
D005978Glutathione[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac24246759
D005978GlutathioneSulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]24246759
C010974glyphosateglyphosate results in decreased activity of CYP2C9 protein20183062
D006861Hydrogen PeroxideCYP2C9 protein results in increased abundance of Hydrogen Peroxide25061110
C031014hydroxymethyltolbutamideCYP2C9 protein results in increased chemical synthesis of hydroxymethyltolbutamide15155557
C001654hyperforinhyperforin results in increased expression of and results in increased activity of CYP2C9 protein15100173
C001654hyperforinhyperforin results in increased expression of CYP2C9 mRNA14600250|1510017
C001654hyperforinNR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]14600250
D007052IbuprofenCYP2C9 gene polymorphism results in decreased metabolism of Ibuprofen15289789|1869483
D007052IbuprofenCYP2C9 protein affects the susceptibility to Ibuprofen25578229
D007052IbuprofenCYP2C9 protein binds to Ibuprofen15039296
D007052IbuprofenCYP2C9 protein polymorphism affects the metabolism of Ibuprofen12152005
D007052IbuprofenCYP2C9 protein results in increased metabolism of Ibuprofen12464242|1768116
D007052IbuprofenIbuprofen inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D007069IfosfamideCYP2C9 protein results in increased susceptibility to Ifosfamide20507880
D007069IfosfamideCYP2C9 results in increased activity of Ifosfamide9241661
D007069IfosfamideCYP2C9 affects the activity of Ifosfamide16475710
C081309irbesartanCYP2C9 gene polymorphism results in decreased susceptibility to irbesartan12359989
C081309irbesartanCYP2C9 protein results in increased metabolism of irbesartan12359989
C051890irinotecanirinotecan metabolite results in decreased activity of CYP2C9 protein11901092
C549713isocarbophosCYP2C9 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos24752505
C028904isoproturonisoproturon results in decreased activity of CYP2C9 protein18420780
D017275IsradipineIsradipine results in decreased activity of CYP2C9 protein27732883
D017964ItraconazoleItraconazole results in decreased activity of CYP2C9 protein16556082
D007559IvermectinIvermectin results in decreased activity of CYP2C9 protein18420780
C006552kaempferolkaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D007654KetoconazoleKetoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D007654KetoconazoleKetoconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D007654KetoconazoleKetoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]16608920
D007654KetoconazoleKetoconazole inhibits the reaction [Rifampin results in increased expression of CYP2C9 mRNA]16608920
D007654KetoconazoleKetoconazole results in decreased activity of CYP2C9 protein14709627|1561874
D007654KetoconazoleKetoconazole results in decreased expression of CYP2C9 mRNA16608920
D007654KetoconazoleKetoconazole results in decreased activity of CYP2C9 protein18420780
D007654KetoconazoleKetoconazole results in decreased activity of CYP2C9 protein16556082
D007660KetoprofenKetoprofen inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D064747LansoprazoleCYP2C9 protein results in increased hydroxylation of Lansoprazole12975331|8627562
D064747LansoprazoleLansoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
C030358lauric acidCYP2C9 gene polymorphism results in decreased hydroxylation of lauric acid11455026
C030358lauric acidCYP2C9 protein results in increased hydroxylation of lauric acid11455026|9241660
D007854LeadLead results in decreased expression of CYP2C9 mRNA19921347
C070840licochalcone Alicochalcone A results in decreased activity of CYP2C9 protein26100226
D008095Lithocholic AcidLithocholic Acid results in decreased activity of CYP2C9 protein18420780
D019808LosartanCYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Losartan]25994031|2599403
D019808LosartanCYP2C9 protein affects the metabolism of Losartan20405111|2132106
D019808LosartanCYP2C9 protein results in increased hydroxylation of Losartan25994031
D019808LosartanCYP2C9 protein results in increased metabolism of Losartan19082874|1971573
D019808Losartanresveratrol inhibits the reaction [CYP2C9 protein results in increased metabolism of Losartan]20716633
D019808LosartanCYP2C9 protein results in increased metabolism of Losartan10197301
D008294MalathionMalathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
D008294MalathionMalathion results in decreased activity of CYP2C9 protein20183062|2263405
C501277Mangifera indica extractMangifera indica extract results in decreased activity of CYP2C9 protein22815239
C013592mangiferinmangiferin results in decreased activity of CYP2C9 protein22815239
C054218manidipinemanidipine results in decreased activity of CYP2C9 protein10805063
D008528Mefenamic AcidCYP2C9 protein results in increased glutathionylation of Mefenamic Acid analog25372302
D008528Mefenamic AcidCYP2C9 protein results in increased hydroxylation of Mefenamic Acid25372302
D008528Mefenamic AcidCYP2C9 protein results in increased metabolism of Mefenamic Acid12464242
D008549MelarsoprolMelarsoprol results in decreased activity of CYP2C9 protein11124226
D008610MentholMenthol results in increased expression of CYP2C9 mRNA24594507
D008617MephenytoinCYP2C9 protein affects the metabolism of Mephenytoin16648389
D008617MephenytoinCYP2C9 protein results in increased hydrolysis of Mephenytoin21347438
D008617MephenytoinMephenytoin results in decreased activity of CYP2C9 protein18420780
C050699mepirodipinemepirodipine results in decreased activity of CYP2C9 protein10805063
D003915DextromethorphanDextromethorphan results in decreased activity of CYP2C9 protein18420780
D008727MethotrexateMethotrexate results in decreased expression of CYP2C9 mRNA24449571
D008731Methoxychlor[CYP2C19 protein co-treated with CYP2C9 protein] results in decreased methylation of Methoxychlor15486075
D008731MethoxychlorCYP2C9 protein results in decreased methylation of Methoxychlor12167570|9733665
D008731MethoxychlorMethoxychlor results in decreased activity of CYP2C9 protein18420780
D008731MethoxychlorCYP2C9 protein results in increased metabolism of Methoxychlor18585438
D008730MethoxsalenMethoxsalen results in decreased activity of CYP2C9 protein18420780
C076881methysticinmethysticin results in decreased activity of CYP2C9 protein16033948
D008795MetronidazoleMetronidazole results in decreased activity of CYP2C9 protein15869686
D008825MiconazoleMiconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D008825MiconazoleMiconazole results in decreased activity of CYP2C9 protein15328084
D008874MidazolamMidazolam results in decreased activity of CYP2C9 protein18420780
C518174MK-0524CYP2C9 protein results in increased metabolism of MK-052417132765
C479069mono(2-ethyl-5-hydroxyhexyl) phthalate[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate23545481
C479069mono(2-ethyl-5-hydroxyhexyl) phthalate[CYP2C9 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate22186153
C080276mono(2-ethyl-5-oxohexyl)phthalate[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate23545481
C080276mono(2-ethyl-5-oxohexyl)phthalate[CYP2C9 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate22186153
C016599mono-(2-ethylhexyl)phthalateCYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate23545481
C016599mono-(2-ethylhexyl)phthalate[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of 2-ethyl-5-carboxypentyl phthalate23545481
C016599mono-(2-ethylhexyl)phthalate[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate23545481
C016599mono-(2-ethylhexyl)phthalate[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate23545481
C016599mono-(2-ethylhexyl)phthalate[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid23545481
C016599mono-(2-ethylhexyl)phthalateCYP2C9 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate22186153
C016599mono-(2-ethylhexyl)phthalate[CYP2C9 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate22186153
C016599mono-(2-ethylhexyl)phthalate[CYP2C9 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate22186153
C050132mono-N-demethyladinazolamCYP2C9 protein results in decreased methylation of mono-N-demethyladinazolam9600717
C437683motexafin gadoliniummotexafin gadolinium results in decreased activity of CYP2C9 protein17018578
C031721naphthalenenaphthalene results in increased expression of CYP2C9 mRNA20500019
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CYP2C9 mRNA27344345
D009288NaproxenAmiodarone promotes the reaction [CYP2C9 protein affects the metabolism of Naproxen]16081671
D009288NaproxenBenzbromarone promotes the reaction [CYP2C9 protein affects the metabolism of Naproxen]16081671
D009288NaproxenCYP2C9 gene polymorphism affects the metabolism of Naproxen11901091
D009288NaproxenCYP2C9 protein affects the metabolism of Naproxen16081671
D009288NaproxenCYP2C9 protein polymorphism results in decreased methylation of Naproxen15130760
D009288NaproxenCYP2C9 protein results in decreased methylation of Naproxen15130760
D009288NaproxenCYP2C9 protein results in increased metabolism of Naproxen11901091|1246424
D009288NaproxenDapsone promotes the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]15130760
D009288NaproxenDapsone promotes the reaction [CYP2C9 protein results in decreased methylation of Naproxen]15130760
D009288NaproxenAmiodarone affects the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
D009288NaproxenBenzbromarone affects the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
D009288NaproxenBenzbromarone analog affects the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
D009288NaproxenCYP2C9 protein alternative form results in decreased methylation of Naproxen16815961
D009288Naproxendesethylamiodarone inhibits the reaction [CYP2C9 protein polymorphism results in decreased methylation of Naproxen]16815961
C005273naringeninnaringenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C005274naringinnaringin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
C060142nateglinideCYP2C9 protein affects the metabolism of nateglinide18159128
C060142nateglinideCYP2C9 protein affects the metabolism of nateglinide16042675
D009529NicardipineNicardipine results in decreased activity of CYP2C9 protein10805063|1586389
D009534NiclosamideNiclosamide promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D009534NiclosamideNiclosamide results in increased activity of CYP2C9 protein11124226
D009543NifedipineNifedipine results in decreased activity of CYP2C9 protein18420780
C012655nimesulideCYP2C9 protein results in increased glutathionylation of nimesulide26524229
C574385N,N-didesmethyl-4-hydroxytamoxifen"CYP2C9 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen"29285606
C574385N,N-didesmethyl-4-hydroxytamoxifen"[CYP2C9 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen] which results in increased abundance of N,N-didesmethyl-4-hydroxytamoxifen"29285606
C574385N,N-didesmethyl-4-hydroxytamoxifen"N,N-didesmethyl-4-hydroxytamoxifen results in decreased activity of CYP2C9 protein"29285606
C058272norclozapineCYP2C9 protein results in increased chemical synthesis of norclozapine18809730
C036139norfluoxetine[CYP2C9 affects the metabolism of Fluoxetine] which results in increased chemical synthesis of norfluoxetine11304903
C464660obeticholic acidobeticholic acid results in decreased expression of CYP2C9 mRNA27939613
C025589ochratoxin ACYP2C9 protein results in increased susceptibility to ochratoxin A21781659|8542584
C025589ochratoxin Aochratoxin A results in increased expression of CYP2C9 mRNA21834667
D019787Linoleic AcidCYP2C9 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]16978661
D019787Linoleic AcidLinoleic Acid results in decreased activity of CYP2C9 protein16978661
D009853OmeprazoleOmeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
D009853OmeprazoleOmeprazole results in decreased activity of CYP2C9 protein18420780
D062367ortho-Aminobenzoatesortho-Aminobenzoates analog results in decreased activity of CYP2C9 protein17994679
D062367ortho-Aminobenzoatesortho-Aminobenzoates results in decreased activity of CYP2C9 protein18477506
D010098OxycodoneOxycodone results in decreased expression of CYP2C9 mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of CYP2C9 mRNA19695866
D017239PaclitaxelPaclitaxel results in decreased activity of CYP2C9 protein19909766
D017239PaclitaxelPaclitaxel results in increased activity of CYP2C9 protein19202563
C064276pantoprazolepantoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
D010278ParathionCYP2C9 protein affects the metabolism of Parathion17079358
D010278ParathionParathion results in increased expression of CYP2C9 mRNA26196221
D010419PentamidinePentamidine results in decreased activity of CYP2C9 protein11124226
D010464PerazineCYP2C9 gene polymorphism affects the metabolism of Perazine11026737
D010464PerazineCYP2C9 protein results in decreased methylation of Perazine11026737
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]21964418
C569762PF 03715455PF 03715455 results in decreased activity of CYP2C9 protein21888439
D010622PhencyclidineCYP2C9 protein affects the metabolism of Phencyclidine16782764
D010634PhenobarbitalCYP2C9 gene polymorphism affects the metabolism of Phenobarbital17304159
D010634PhenobarbitalEstradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
D010634PhenobarbitalKetoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]16608920
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]]21768169
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]]21768169
D010634PhenobarbitalPhenobarbital results in decreased activity of CYP2C9 protein19909766
D010634PhenobarbitalPhenobarbital results in increased activity of and results in increased expression of CYP2C9 protein19202563
D010634PhenobarbitalPhenobarbital results in increased activity of CYP2C9 mRNA19202563
D010634PhenobarbitalPhenobarbital results in increased activity of CYP2C9 protein19328226
D010634PhenobarbitalPhenobarbital results in increased expression of and results in increased activity of CYP2C9 protein15802389
D010634PhenobarbitalPhenobarbital results in increased expression of CYP2C9 mRNA15629111|1580238
D010634Phenobarbital[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
D010634PhenobarbitalProgesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
D010634PhenobarbitalPhenobarbital results in increased expression of CYP2C919445531
C033457phenobarbital quinidineIL1B protein inhibits the reaction [phenobarbital quinidine results in increased expression of CYP2C9 mRNA]15382119
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of CYP2C9 mRNA15382119
D010644PhenprocoumonCYP2C9 gene polymorphism affects the susceptibility to Phenprocoumon18698879
D010644PhenprocoumonCYP2C9 protein results in increased metabolism of Phenprocoumon19082874
C008838phenthoatephenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
C008838phenthoatephenthoate results in decreased activity of CYP2C9 protein22634058
D010653PhenylbutazonePhenylbutazone inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D010672Phenytoin[Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin17961958
D010672Phenytoin[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin23397584
D010672PhenytoinCYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin11503012
D010672PhenytoinCYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin16873909|9860067
D010672PhenytoinCYP2C9 gene polymorphism results in decreased metabolism of Phenytoin10208645|1143450
D010672PhenytoinCYP2C9 gene polymorphism results in increased susceptibility to Phenytoin11740344
D010672PhenytoinCYP2C9 protein affects the metabolism of Phenytoin15855726|2040511
D010672PhenytoinCYP2C9 protein alternative form affects the metabolism of Phenytoin27163851
D010672PhenytoinCYP2C9 protein results in increased hydroxylation of Phenytoin16873909|2025243
D010672PhenytoinCYP2C9 protein results in increased metabolism of Phenytoin10208645|1051015
D010672PhenytoinNR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]14600250
D010672PhenytoinPhenytoin results in increased activity of CYP2C9 protein19202563
D010672PhenytoinPhenytoin results in increased expression of CYP2C9 mRNA14600250
D010672PhenytoinCYP2C9 protein results in increased metabolism of Phenytoin15569425
D010672PhenytoinCYP2C9 protein results in increased metabolism of Phenytoin19952982
C032279phthalic acid[CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid23545481
C556557picoxystrobinpicoxystrobin results in decreased activity of CYP2C9 protein23611293
D010894PiroxicamCYP2C9 gene polymorphism affects the metabolism of Piroxicam11901091
D010894PiroxicamCYP2C9 protein results in increased metabolism of Piroxicam11901091|1246424
D010894PiroxicamPiroxicam inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D010936Plant ExtractsPlant Extracts results in decreased activity of CYP2C9 protein15992226|2082860
D010936Plant ExtractsPlant Extracts results in decreased expression of CYP2C9 mRNA19041297|2355793
D010936Plant ExtractsPlant Extracts results in decreased expression of CYP2C9 protein19041297
D010936Plant ExtractsPlant Extracts results in decreased activity of CYP2C9 protein16033948
D028321Plant PreparationsPlant Preparations results in decreased activity of CYP2C9 protein26530625
D028321Plant PreparationsPlant Preparations results in increased expression of CYP2C9 mRNA26530625
C047681pranlukastpranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]15370959
C047681pranlukastpranlukast results in decreased activity of CYP2C9 protein15370959
C024273profenofosprofenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
C024273profenofosprofenofos results in decreased activity of CYP2C9 protein22634058
D011374Progesterone"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]]"21768169
D011374ProgesteroneNR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]]21768169
D011374Progesterone"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D011374Progesterone"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
D011374Progesterone[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]"21768169
D011374ProgesteroneProgesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]21768169
C005556propionaldehydepropionaldehyde results in decreased expression of CYP2C9 mRNA26079696
D011433PropranololCYP2C9 protein results in increased oxidation of Propranolol19853591
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]24830941
C030984pyreneCYP2C9 protein affects the hydroxylation of pyrene15044613
D011739PyrimethaminePyrimethamine results in decreased activity of CYP2C9 protein11124226
D011794QuercetinQuercetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]21053930
D011794QuercetinQuercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D011794QuercetinQuercetin results in decreased activity of CYP2C9 protein18420780
D011794QuercetinQuercetin results in increased expression of CYP2C9 mRNA21632981
D011802QuinidineQuinidine results in decreased activity of CYP2C9 protein18420780
D011803QuinineQuinine inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D011803QuinineQuinine results in decreased activity of CYP2C9 protein11124226
C523099rabeprazole-thioetherrabeprazole-thioether inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]15258107
C059514resveratrolresveratrol inhibits the reaction [CYP2C9 protein results in increased metabolism of Losartan]20716633
C059514resveratrolresveratrol results in decreased activity of CYP2C9 protein18420780
C020491rheinrhein results in decreased activity of CYP2C9 protein27633141
D012293RifampinKetoconazole inhibits the reaction [Rifampin results in increased expression of CYP2C9 mRNA]16608920
D012293RifampinNCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]]21292004
D012293RifampinNR1I2 protein affects the reaction [Rifampin results in increased expression of CYP2C9 mRNA]14600250
D012293RifampinRifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP2C9 mRNA]21292004
D012293RifampinRifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]21292004
D012293RifampinRifampin promotes the reaction [NR1I2 protein results in increased expression of CYP2C9 mRNA]21292004
D012293RifampinRifampin results in increased activity of and results in increased expression of CYP2C9 protein19202563
D012293RifampinRifampin results in increased activity of CYP2C9 protein14722322|1949736
D012293RifampinRifampin results in increased expression of and results in increased activity of CYP2C9 protein14709624|1580238
D012293RifampinRifampin results in increased expression of CYP2C9 mRNA14600250|1472232
D012293RifampinRifampin results in increased expression of CYP2C9 protein17590308|1904129
D012293RifampinRifampin results in increased expression of CYP2C919445531
D019438RitonavirRitonavir results in increased activity of CYP2C9 protein19202563
D019438RitonavirRitonavir results in increased expression of CYP2C9 mRNA11918509
D020280SertralineCYP2C9 protein results in decreased methylation of and results in increased metabolism of Sertraline15547048
D020280SertralineSertraline inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
C016101shikoninshikonin results in decreased activity of CYP2C9 protein28941798
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CYP2C9 mRNA25895662
C440975silybinsilybin results in decreased activity of CYP2C9 protein15155549
D019821SimvastatinSimvastatin affects the reaction [CYP2C9 polymorphism affects the susceptibility to Warfarin]22594507
D020123SirolimusSirolimus results in decreased expression of CYP2C9 protein25929522
D020123SirolimusSirolimus results in increased expression of CYP2C9 mRNA25929522
C106276sitaxsentansitaxsentan inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]23721565
C001873sporidesminsporidesmin results in increased expression of CYP2C9 mRNA28193462
C012042steviolsteviol binds to and results in decreased activity of CYP2C9 protein28887089
C012043steviosidestevioside results in decreased expression of CYP2C9 mRNA28887089
C024075styrofoamstyrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2C9 protein]19909766
C024075styrofoamstyrofoam analog results in decreased activity of CYP2C9 protein19909766
D013411SulfadiazineCYP2C9 protein results in increased hydroxylation of Sulfadiazine15843491
D013420SulfamethoxazoleCYP2C9 protein results in increased oxidation of Sulfamethoxazole25170804
D013420Sulfamethoxazole[CYP2C9 protein results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of sulfamethoxazole hydroxylamine25170804
C059873sulfamethoxazole hydroxylamineCYP2C9 protein results in increased chemical synthesis of sulfamethoxazole hydroxylamine25170804
C059873sulfamethoxazole hydroxylamine[CYP2C9 protein results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of sulfamethoxazole hydroxylamine25170804
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D013426SulfaphenazoleCYP2C9 protein results in increased metabolism of Sulfaphenazole17702393|1930915
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]24246759
D013426Sulfaphenazole"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]"12675279
D013426Sulfaphenazole"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]"12675279
D013426Sulfaphenazole"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]"12675279
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]11377097
D013426Sulfaphenazole"Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]"19697924
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Arachidonic Acid]12675279
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]23850985
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]12569440|2811916
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]23850985
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased oxidation of 2-oxo-clopidogrel]19812348
D013426SulfaphenazoleSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased susceptibility to Cyclophosphamide]10991840
D013426SulfaphenazoleSulfaphenazole results in decreased activity of CYP2C9 protein12464242|1246791
D013426Sulfaphenazole[Sulfaphenazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac22447115|2659997
D013426SulfaphenazoleSulfaphenazole results in decreased expression of CYP2C9 mRNA24519941
D013426SulfaphenazoleSulfaphenazole results in decreased activity of CYP2C9 protein10828259|1694598
D013442SulfinpyrazoneSulfinpyrazone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D013453Sulfonylurea CompoundsCYP2C9 gene polymorphism affects the susceptibility to Sulfonylurea Compounds19715737
D014284TriiodothyronineTriiodothyronine promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins]14557374
D013629Tamoxifen[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen23397584
D013629TamoxifenTamoxifen metabolite results in increased activity of CYP2C9 protein29285606
D013629TamoxifenTamoxifen results in decreased activity of CYP2C9 protein18420780
D000068698TenofovirTenofovir results in decreased activity of CYP2C9 protein17162464
D013739TestosteroneCYP2C9 protein affects the metabolism of Testosterone16648389
D013739TestosteroneTestosterone results in decreased activity of CYP2C9 protein18420780
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP2C9 mRNA16985168
D013827ThiabendazoleThiabendazole results in decreased activity of CYP2C9 protein11124226
C109005thiocoralineCYP2C9 protein affects the metabolism of thiocoraline15122071
D008063Thioctic AcidThioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D013881Thioridazine[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine23397584
D013881ThioridazineThioridazine results in decreased activity of CYP2C9 protein15135088
D013988TiclopidineCYP2C9 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite19170597
D013989TicrynafenCYP2C9 protein affects the metabolism of Ticrynafen21321060
D013989TicrynafenCYP2C9 protein results in increased metabolism of Ticrynafen12464242
D013989TicrynafenCYP2C9 protein results in increased susceptibility to Ticrynafen28762043
D013989TicrynafenTicrynafen inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]16049126
D013989TicrynafenTicrynafen results in decreased activity of CYP2C9 protein15860655|1604912
D013989TicrynafenCYP2C9 protein results in increased metabolism of Ticrynafen22329513
D013989TicrynafenCYP2C9 protein results in increased oxidation of Ticrynafen analog22329513
D013989TicrynafenTicrynafen metabolite binds to and results in decreased activity of CYP2C9 protein22329513
D014044TolbutamideCYP2C9 protein affects the hydroxylation of Tolbutamide9004453
D014044TolbutamideDiclofenac inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D014044TolbutamideFlurbiprofen inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D014044TolbutamideKetoprofen inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D014044TolbutamidePhenylbutazone inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D014044TolbutamideSulfaphenazole inhibits the reaction [CYP2C9 protein affects the hydroxylation of Tolbutamide]9004453
D014044TolbutamideAcetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]10611138
D014044Tolbutamideacetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]10611138
D014044TolbutamideCYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]25994031|2599403
D014044TolbutamideCYP2C9 gene polymorphism affects the metabolism of Tolbutamide15045499
D014044TolbutamideCYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide10208645|9110362
D014044TolbutamideCYP2C9 gene SNP affects the metabolism of Tolbutamide11875364|1242652
D014044TolbutamideCYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide9170147
D014044TolbutamideCYP2C9 protein affects the hydroxylation of Tolbutamide9170147
D014044TolbutamideCYP2C9 protein affects the metabolism of Tolbutamide11875364|1242652
D014044TolbutamideCYP2C9 protein binds to and affects the metabolism of Tolbutamide15856409
D014044TolbutamideCYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite23850985
D014044TolbutamideCYP2C9 protein results in increased hydrolysis of Tolbutamide11377097
D014044TolbutamideCYP2C9 protein results in increased hydroxylation of Tolbutamide10611138|1243379
D014044TolbutamideCYP2C9 protein results in increased metabolism of Tolbutamide10208645|1246424
D014044TolbutamideFenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
D014044TolbutamideMalathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
D014044Tolbutamidephenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
D014044Tolbutamidepranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]15370959
D014044Tolbutamideprofenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]22634058
D014044TolbutamideSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]11377097
D014044TolbutamideSulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]23850985
D014044TolbutamideTolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D014044Tolbutamidezafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]15370959
C026116torsemideCYP2C9 protein results in increased hydroxylation of torsemide9110362
C026116torsemideCYP2C9 protein results in increased metabolism of torsemide19082874
C507866trans-1,2-dihydro-1,2-naphthalenediol"CYP2C9 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediol"16243959
C542064trantinteroltrantinterol results in decreased activity of CYP2C9 protein21466844
D014191TranylcypromineTranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D014212TretinoinCYP2C9 protein results in increased hydroxylation of Tretinoin10874126
D014212TretinoinTretinoin results in decreased activity of CYP2C9 protein18420780
D014212TretinoinTretinoin results in decreased expression of CYP2C9 mRNA16985168
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP2C9 mRNA"24407104
C057693troglitazone[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone23397584
C057693troglitazonetroglitazone results in decreased activity of CYP2C9 protein12642470
D014363TryptaminesTryptamines analog results in decreased activity of CYP2C9 protein26599973
D014363Tryptamines[Tryptamines analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac26599973
D014635Valproic AcidCYP2C9 polymorphism results in increased susceptibility to Valproic Acid20398172
D014635Valproic AcidCYP2C9 protein results in increased metabolism of Valproic Acid16945988|2060262
D014635Valproic AcidValproic Acid results in decreased expression of CYP2C9 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of CYP2C9 mRNA25084468
D014700VerapamilVerapamil results in decreased activity of CYP2C9 protein18420780
D014750VincristineCYP2C9 gene SNP results in increased susceptibility to Vincristine21245421
D002762CholecalciferolCholecalciferol metabolite results in increased expression of CYP2C911991950
D002762CholecalciferolCholecalciferol results in decreased activity of CYP2C9 protein18420780
D065819VoriconazoleCYP2C9 protein affects the metabolism of Voriconazole15914520
D065819VoriconazoleVoriconazole results in decreased activity of CYP2C9 protein15328084|1591452
D065819VoriconazoleVoriconazole results in decreased activity of CYP2C9 protein16556082
D014859Warfarin10-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
D014859Warfarin4'-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
D014859Warfarin6-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
D014859Warfarin7-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin]20429590
D014859Warfarin8-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]20429590
D014859WarfarinBenzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Warfarin]10613612
D014859WarfarinCYP2C9 affects the susceptibility to Warfarin22907842
D014859WarfarinCYP2C9 enhancer polymorphism affects the metabolism of Warfarin17332144
D014859WarfarinCYP2C9 gene affects the metabolism of Warfarin11307788
D014859WarfarinCYP2C9 gene affects the susceptibility to Warfarin11127854|1130778
D014859WarfarinCYP2C9 gene mutant form affects the susceptibility to Warfarin20354686|2126118
D014859WarfarinCYP2C9 gene mutant form results in increased susceptibility to Warfarin25994031|2625566
D014859WarfarinCYP2C9 gene polymorphism affects the abundance of Warfarin25986145
D014859WarfarinCYP2C9 gene polymorphism affects the hydrolysis of Warfarin9698079
D014859WarfarinCYP2C9 gene polymorphism affects the metabolism of Warfarin12621390
D014859WarfarinCYP2C9 gene polymorphism affects the susceptibility to and affects the metabolism of Warfarin26469104
D014859WarfarinCYP2C9 gene polymorphism affects the susceptibility to Warfarin14656880|1469157
D014859WarfarinCYP2C9 gene polymorphism results in decreased hydroxylation of Warfarin11455026
D014859WarfarinCYP2C9 gene polymorphism results in decreased metabolism of Warfarin20073138
D014859WarfarinCYP2C9 gene polymorphism results in decreased susceptibility to Warfarin18030307|1803461
D014859WarfarinCYP2C9 gene polymorphism results in increased susceptibility to Warfarin11794436|1989932
D014859WarfarinCYP2C9 gene SNP affects the susceptibility to Warfarin20442691|2065367
D014859WarfarinCYP2C9 polymorphism affects the susceptibility to Warfarin17510308|1789550
D014859WarfarinCYP2C9 protein affects the hydroxylation of Warfarin10613612
D014859WarfarinCYP2C9 protein affects the metabolism of Warfarin14586384|1467682
D014859WarfarinCYP2C9 protein affects the susceptibility to Warfarin15952022|1745682
D014859WarfarinCYP2C9 protein polymorphism affects the susceptibility to Warfarin23800980|2460197
D014859WarfarinCYP2C9 protein results in increased hydrolysis of Warfarin9698079
D014859WarfarinCYP2C9 protein results in increased hydroxylation of Warfarin11455026|1243379
D014859Warfarin[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin20429590
D014859Warfarin[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin20429590
D014859WarfarinCYP2C9 protein results in increased metabolism of Warfarin12464242|1687844
D014859Warfarin[CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin19408964
D014859Warfarin[CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin19408964
D014859WarfarinCYP2C9 protein results in increased susceptibility to Warfarin17049586|1711119
D014859WarfarinCYP2C9 results in increased susceptibility to Warfarin20420818
D014859WarfarinCYP2C9 SNP affects the susceptibility to Warfarin24966969|2807979
D014859WarfarinCYP2C9 SNP affects the susceptibility to Warfarin analog25499099
D014859WarfarinSimvastatin affects the reaction [CYP2C9 polymorphism affects the susceptibility to Warfarin]22594507
D014859Warfarin[Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA20735727
D014859WarfarinWarfarin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
D014859WarfarinWarfarin results in decreased activity of CYP2C9 protein18420780
D014859WarfarinCYP2C9 protein affects the hydroxylation of Warfarin15044613
D014859WarfarinCYP2C9 protein affects the metabolism of Warfarin18763667
C062735zafirlukastzafirlukast inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]16081671
C062735zafirlukastzafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]15370959
C062735zafirlukastzafirlukast results in decreased activity of CYP2C9 protein15370959
C088658zoledronic acidzoledronic acid results in increased expression of CYP2C9 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-IDA19651758  
GO:0004497monooxygenase activity-NAS2827463  
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0008144drug binding-IDA19448135  
GO:0008392arachidonic acid epoxygenase activity-IBA21873635  
GO:0008395steroid hydroxylase activity-IBA21873635  
GO:0008395steroid hydroxylase activity-IMP18356043  
GO:0016491oxidoreductase activity-IDA16401082  19219744  
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0034875caffeine oxidase activity-IDA18619574  
GO ID GO Term Qualifier Evidence PubMed
GO:0006082organic acid metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0008202steroid metabolic process-IMP18356043  
GO:0016098monoterpenoid metabolic process-IDA16401082  
GO:0017144drug metabolic process-IDA19219744  19651758  
GO:0017144drug metabolic process-IMP21127708  
GO:0019373epoxygenase P450 pathway-TAS-  
GO:0019627urea metabolic process-IDA19029318  
GO:0032787monocarboxylic acid metabolic process-IDA19651758  
GO:0042737drug catabolic process-IMP18356043  
GO:0042738exogenous drug catabolic process-IBA21873635  
GO:0042738exogenous drug catabolic process-IDA18619574  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0043603cellular amide metabolic process-IDA19651758  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IDA16401082  19219744  
GO:0070989oxidative demethylation-IDA18619574  
GO:0097267omega-hydroxylase P450 pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IDA9618440  
GO:0043231intracellular membrane-bounded organelle-TAS2827463  3032244  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa00591Linoleic acid metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211981XenobioticsTAS
R-HSA-211999CYP2E1 reactionsTAS
R-HSA-2142670Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2142816Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9018682Biosynthesis of maresinsTAS
R-HSA-9027307Biosynthesis of maresin-like SPMsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21047199Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort. (2010 Oct)Haschke-Becher EPharmacogenomics
23210243Development and comparison of a new personalized warfarin stable dose prediction algorithm in Chinese patients undergoing heart valve replacement. (2012 Nov)Tan SLPharmazie
21450231Failure of pharmacogenetic-based dosing algorithms to identify older patients requiring low daily doses of warfarin. (2011 Nov)Schwartz JBJ Am Med Dir Assoc
19998810Pharmacogenetics and anticoagulant therapy: two cases of genetically determined response to warfarin. (2009 Sep)Cortez-Dias NRev Port Cardiol
25136521Association of cytochrome P450 2C9 polymorphism with locally advanced head and neck squamous cell carcinoma and response to concurrent cisplatin-based radical chemoradiation. (2014 Jul)Paul SSouth Asian J Cancer
26669712P450 (Cytochrome) Oxidoreductase Gene (POR) Common Variant (POR*28) Significantly Alters CYP2C9 Activity in Swedish, But Not in Korean Healthy Subjects. (2015 Dec)Hatta FHOMICS
16188404Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells. (2005 Dec 15)Malaplate-Armand CToxicol Lett
15090158A high throughput screening assay to screen for CYP2E1 metabolism and inhibition using a fluorogenic vivid p450 substrate. (2002 Nov)Marks BDAssay Drug Dev Technol
18216720Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding. (2008 Jan)Blanco GPharmacogenet Genomics
21053990Effect of intrinsic and extrinsic factors on the clinical pharmacokinetics and pharmacodynamics of prasugrel. (2010 Dec)Small DSClin Pharmacokinet
15924351Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study. (2005 Sep)Tranah GJMol Carcinog
22149257A pharmacokinetic-pharmacodynamic model for predicting the impact of CYP2C9 and VKORC1 polymorphisms on fluindione and acenocoumarol during induction therapy. (2012 Jan 1)Verstuyft CClin Pharmacokinet
17868191Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis. (2008 Apr)Ercan BCell Biochem Funct
26739746A multi-factorial analysis of response to warfarin in a UK prospective cohort. (2016 Jan 6)Bourgeois SGenome Med
15327588A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. (2004 Sep)Sharma ABr J Clin Pharmacol
17387222Genetic-based dosing in orthopedic patients beginning warfarin therapy. (2007 Sep 1)Millican EABlood
25986145Warfarin Metabolites in Patients Following Cardiac Valve Implantation: A Contribution of Clinical and Genetic Factors. (2015 Jun)Bryk ACardiovasc Drugs Ther
15290664A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma. (2004 Aug)Chan ATClin Gastroenterol Hepatol
22969879Association between cytochrome P450 promoter polymorphisms and ischemic stroke. (2012 Feb)Kim SKExp Ther Med
20937634Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. (2010 Nov 1)Cleary SPAm J Epidemiol
19350405Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai. (2009 Dec)Wen HInt Urol Nephrol
11911968Influence of cytochrome P450 CYP2C9 genotypes in lung cancer risk. (2002 Jun 6)Garcia-Martin ECancer Lett
23061746Impact of genetic factors (CYP2C9, VKORC1 and CYP4F2) on warfarin dose requirement in the Turkish population. (2013 Mar)Ozer MBasic Clin Pharmacol Toxicol
12682803Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. (2003 May)Berecz REur J Clin Pharmacol
21766908Development of cocaine-induced interstitial lung damage in two CYP2C and VKORC1 variant allele carriers. (2011 Jun 1)Wijnen PAMol Diagn Ther
11535249Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure. (2001 Oct 1)Schoket BMutat Res
16758259Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin. (2006 Jun)Kim MJEur J Clin Pharmacol
21149643Genetic polymorphism and toxicology--with emphasis on cytochrome p450. (2011 Mar)Johansson IToxicol Sci
29776219A simulation of warfarin maintenance dose requirement using a pharmacogenetic algorithm in an ethnically diverse cohort. (2010 May)Gladding PPer Med
23081681CYP2C9 variants increase risk of colorectal adenoma recurrence and modify associations with smoking but not aspirin treatment. (2013 Jan)Barry ELCancer Causes Control
24408517Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. (2014 Apr)Achour BDrug Metab Dispos
29333880Pharmacogenetic analysis of opioid dependence treatment dose and dropout rate. (2018)Crist RCAm J Drug Alcohol Abuse
24911077CYP2C9, VKORC1, CYP4F2, ABCB1 and F5 variants: influence on quality of long-term anticoagulation. (2014 Apr)Nahar RPharmacol Rep
19032008Pharmacogenomic dosing of warfarin: ready or not? (2008 Aug)Lackner TEConsult Pharm
23800980Factors affecting warfarin dose requirements and quality of anticoagulation in adult Egyptian patients: role of gene polymorphism. (2014 Jun)Bazan NSIr J Med Sci
25977991Differences in CYP2C9 Genotype and Enzyme Activity Between Swedes and Koreans of Relevance for Personalized Medicine: Role of Ethnicity, Genotype, Smoking, Age, and Sex. (2015 Jun)Hatta FHOMICS
22629463Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians. (2012)Rathore SSPLoS One
11353760Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. (2001 Jun)Zhang WDrug Metab Dispos
20709439Warfarin dosing in patients with impaired kidney function. (2010 Nov)Limdi NAAm J Kidney Dis
21110013Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. (2011 Apr)Geisen CEur J Clin Pharmacol
21589866Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response. (2011 May 12)Fonseca FPLoS One
22108250Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides. (2012 Jan 24)Singh SMutat Res
28049362Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients. (2018 Mar)Gaikwad TClin Appl Thromb Hemost
16128907Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo. (2005 Sep)Larsen JTBasic Clin Pharmacol Toxicol
11502731Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes. (2001 Sep)Cherstniakova SADrug Metab Dispos
21768671Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer. (2011 Apr-Jun)Paul SIndian J Cancer
21228733Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients. (2011 Mar)Shahin MHPharmacogenet Genomics
7741772Hydroxylation of the antimalarial drug 58C80 by CYP2C9 in human liver microsomes: comparison with mephenytoin and tolbutamide hydroxylations. (1995 Mar 30)Weaver RJBiochem Pharmacol
26095139Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)Toselli FXenobiotica
27275407Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome. (2014 Mar 1)Yadav SSAppl Transl Genom
12214673Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. (2002 Aug)Kamataki TDrug Metab Rev