Gene: GRK2

156
ADRBK1|BARK1|BETA-ARK1
G protein-coupled receptor kinase 2
protein-coding
11q13.2
Ensembl:ENSG00000173020 MIM:109635 Vega:OTTHUMG00000167104 UniprotKB:P25098
NC_000011.10
PubMed
0   ANCO-SNPs
CD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.729e-1 (AD)  6.505e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GRK2 mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GRK2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GRK2 mRNA"21346803
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of GRK2 mRNA"26186136
D000082AcetaminophenAcetaminophen affects the expression of GRK2 mRNA17562736
D000242Cyclic AMP[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] promotes the reaction [GRK2 protein binds to GLP1R protein]25191754
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GRK2 mRNA19770486
D000526AlprenololAlprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]12198331
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRK2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GRK2 mRNA24449571
D001262AtenololAtenolol results in decreased expression of GRK2 mRNA9788834
D001262AtenololAtenolol results in decreased expression of GRK2 protein9788834
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRK2 mRNA19770486
C095105bexarotenebexarotene results in increased expression of GRK2 mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of GRK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GRK2 mRNA26141625
C043211carvedilol[carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein10455254
C043211carvedilolcarvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]12198331
C043211carvedilolcarvedilol results in decreased expression of GRK2 protein9788834
C043211carvedilolcarvedilol results in increased expression of GRK2 protein10455254
C000602816CCG215022CCG215022 results in decreased activity of GRK2 protein26032411
D004390ChlorpyrifosChlorpyrifos inhibits the reaction [GRK2 protein results in increased phosphorylation of CHRM2 protein]16824341
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GRK2 mRNA17452286
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRK2 mRNA20691718
D003042CocaineCocaine affects the expression of GRK2 mRNA20187946
D003042CocaineCocaine results in increased expression of GRK2 mRNA16076954
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of GRK2 mRNA16556975
D003891DesipramineDesipramine affects the localization of GRK2 protein12527474
D004026DieldrinDieldrin results in increased expression of GRK2 mRNA18812211
D004837EpinephrineEpinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]14722251
C546771gardiquimodgardiquimod results in increased expression of GRK2 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of GRK2 mRNA]28003376
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of GRK2 mRNA16556975
C120099GW 1929GW 1929 results in decreased expression of GRK2 mRNA19420904
C026777ICI 118551[ICI 118551 co-treated with ADRB2 protein] results in increased expression of GRK2 protein10455254
C026777ICI 118551ICI 118551 results in increased expression of GRK2 protein10455254
D007545IsoproterenolIsoproterenol results in increased expression of GRK2 protein9788834
D007545IsoproterenolIsoproterenol results in increased expression of GRK2 mRNA9788834
D007545IsoproterenolIsoproterenol results in increased expression of GRK2 protein9788834
D007545IsoproterenolAGT affects the reaction [Isoproterenol results in decreased expression of GRK2 mRNA]16731636
D007545IsoproterenolIsoproterenol results in increased expression of GRK2 mRNA16731636
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GRK2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of GRK2 mRNA19812364
D009532NickelNickel results in increased expression of GRK2 mRNA18812211
C511689(N)-methanocarba-2MeSADPGRK2 protein inhibits the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of and results in increased activity of AKT1 protein]16236484
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [GRK2 protein results in increased phosphorylation of CHRM2 protein]"16824341
C015405ophiocordinophiocordin results in decreased activity of GRK2 protein26032411
D010269ParaquatParaquat results in decreased expression of GRK2 protein24521700
D017374ParoxetineParoxetine results in decreased activity of GRK2 protein26032411
D010656Phenylephrine[Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein11499749
D010656PhenylephrineGRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]28759639
D010656PhenylephrineGRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]28759639
D010656PhenylephrineGRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]28759639
D010656PhenylephrineGRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]28759639
D010656PhenylephrineGRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]28759639
D010656PhenylephrinePhenylephrine results in increased expression of GRK2 protein28759639
D011433Propranolol[Propranolol co-treated with ADRB2 protein] results in increased expression of GRK2 protein10455254
D011433PropranololPropranolol results in decreased expression of GRK2 protein9788834
D011433PropranololPropranolol results in increased expression of GRK2 protein10455254
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of GRK2 mRNA]28003376
C021315S-nitrosocysteineS-nitrosocysteine results in decreased activity of GRK2 protein17482545
C021315S-nitrosocysteineS-nitrosocysteine results in increased nitrosation of GRK2 protein17482545
C017947sodium arsenitesodium arsenite results in decreased expression of GRK2 mRNA25879800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRK2 mRNA21570461
D014635Valproic AcidValproic Acid results in decreased expression of GRK2 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of GRK2 mRNA21427059
C025643vinclozolinvinclozolin affects the expression of GRK2 mRNA19015723
C009687wortmanninwortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]28759639
C009687wortmanninwortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]28759639
C009687wortmanninwortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]]28759639

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-ISS-  
GO:0004703G-protein coupled receptor kinase activity-ISS-  
GO:0005515protein binding-IPI15620700  17006543  17986524  18369319  19008357  19306925  
19502428  22447027  
GO:0005524ATP binding-IEA-  
GO:0031694alpha-2A adrenergic receptor binding-ISS-  
GO:0031755Edg-2 lysophosphatidic acid receptor binding-IDA19306925  
GO:0047696beta-adrenergic receptor kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002029desensitization of G-protein coupled receptor protein signaling pathway-ISS-  
GO:0003108negative regulation of the force of heart contraction by chemical signal-IMP15051637  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007213G-protein coupled acetylcholine receptor signaling pathway-ISS-  
GO:0007217tachykinin receptor signaling pathway-IDA17986524  
GO:0007507heart development-IEA-  
GO:0018105peptidyl-serine phosphorylation-ISS-  
GO:0018107peptidyl-threonine phosphorylation-IEA-  
GO:0019079viral genome replication-IMP23029581  
GO:0031623receptor internalization-IDA20074556  
GO:0033605positive regulation of catecholamine secretion-ISS-  
GO:0045988negative regulation of striated muscle contraction-IMP15051637  
GO:0046718viral entry into host cell-IMP23029581  
GO:0060048cardiac muscle contraction-IMP15051637  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA17986524  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005929cilium-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-ISS-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5635838Activation of SMOTAS
R-HSA-5635838Activation of SMOIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25213649Cocaine potentiates multiple 5-HT2A receptor signaling pathways and is associated with decreased phosphorylation of 5-HT2A receptors in vivo. (2015 Mar)Franklin JMJ Mol Neurosci
23727505Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. (2013 Sep 5)Alvaro-Bartolome MNeuroscience