Gene info: ID 1562

Gene: CYP2C18

GENE ID: 1562

Synonyms: CPCI|CYP2C|CYP2C17|P450-6B/29C|P450IIC17

Description: cytochrome P450 family 2 subfamily C member 18

Gene type: protein-coding

Location: 10q23.33

dbXrefs: Ensembl:ENSG00000108242 MIM:601131 Vega:OTTHUMG00000018796 UniprotKB:P33260

RefSeq: NG_008373.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.537e-1 (AD) 3.743e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CACNA1H	0.48
SDC1	0.474
WDR86	0.472
KLK5	0.459
WNT9A	0.457
AARD	0.452
KAZALD1	0.451
NOV	0.448
SUSD1	0.448
MCHR1	0.443

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZFHX4-AS1	-0.383
ZFHX4	-0.382
RFTN2	-0.367
DPF3	-0.362
FGFR2	-0.359
MTMR10	-0.356
ZHX2	-0.352
MYO10	-0.35
PON1	-0.345
NFIA	-0.341

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB07670	4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB00082	Pegvisomant	BiotechDrug	218620-50-9	Approved	Enzyme
DB00250	Dapsone	Small Molecule	80-08-0	Approved\|Investigational	Enzyme
DB00252	Phenytoin	Small Molecule	57-41-0	Approved	Enzyme
DB00281	Lidocaine	Small Molecule	137-58-6	Approved	Enzyme
DB00313	Valproic Acid	Small Molecule	99-66-1	Approved\|Investigational	Enzyme
DB00333	Methadone	Small Molecule	76-99-3	Approved	Enzyme
DB00338	Omeprazole	Small Molecule	73590-58-6	Approved\|Investigational	Enzyme
DB00349	Clobazam	Small Molecule	22316-47-8	Approved\|Illicit	Enzyme
DB00448	Lansoprazole	Small Molecule	103577-45-3	Approved\|Investigational	Enzyme
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Enzyme
DB00531	Cyclophosphamide	Small Molecule	50-18-0	Approved\|Investigational	Enzyme
DB00586	Diclofenac	Small Molecule	15307-86-5	Approved	Enzyme
DB00661	Verapamil	Small Molecule	52-53-9	Approved	Enzyme
DB00682	Warfarin	Small Molecule	81-81-2	Approved	Enzyme
DB00755	Tretinoin	Small Molecule	302-79-4	Approved\|Investigational\|Nutraceutical	Enzyme
DB00818	Propofol	Small Molecule	2078-54-8	Approved\|Investigational	Enzyme
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Enzyme
DB00850	Perphenazine	Small Molecule	58-39-9	Approved	Enzyme
DB00921	Buprenorphine	Small Molecule	52485-79-7	Approved\|Illicit\|Investigational	Enzyme
DB01075	Diphenhydramine	Small Molecule	58-73-1	Approved\|Investigational	Enzyme
DB01124	Tolbutamide	Small Molecule	64-77-7	Approved\|Investigational	Enzyme
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Enzyme
DB01174	Phenobarbital	Small Molecule	50-06-6	Approved\|Investigational	Enzyme
DB01181	Ifosfamide	Small Molecule	3778-73-2	Approved	Enzyme
DB01424	Aminophenazone	Small Molecule	58-15-1	Approved\|Withdrawn	Enzyme
DB01435	Antipyrine	Small Molecule	60-80-0	Approved\|Investigational	Enzyme
DB01559	Clotiazepam	Small Molecule	33671-46-4	Approved\|Illicit	Enzyme
DB06684	Vilazodone	Small Molecule	163521-12-8	Approved	Enzyme
DB09166	Etizolam	Small Molecule	40054-69-1	Approved	Enzyme
DB13179	Troleandomycin	Small Molecule	2751-09-9	Approved	Enzyme

ID	Drug Name	Action	PubMed
C495657	1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	"CYP2C18 protein results in increased chemical synthesis of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane"	9733665
C035342	1,4-naphthoquinone	"CYP2C18 protein results in increased abundance of 1,4-naphthoquinone"	16243959
C017062	1-benzylimidazole	1-benzylimidazole results in increased expression of CYP2C18 protein	16714371
C586542	2'-(glutathion-S-yl)-deschlorodiclofenac	[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac	24246759
C545880	4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide	"CYP2C18 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide"	19697924
C117715	5-hydroxydiclofenac	[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac	24246759
C544471	5-hydroxythalidomide	CYP2C18 protein results in increased metabolism of 5-hydroxythalidomide	24350712
D000074	Acenocoumarol	CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarol	19578179
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP2C18 mRNA	21420995\|2906747
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CYP2C18 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CYP2C18 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CYP2C18 gene	27153756
D000638	Amiodarone	CYP2C18 protein results in decreased susceptibility to Amiodarone	26477383
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of CYP2C18 mRNA"	25351596
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of CYP2C18 mRNA	16985168
C018475	butyraldehyde	butyraldehyde results in increased expression of CYP2C18 mRNA	26079696
D002746	Chlorpromazine	CYP2C18 protein results in decreased susceptibility to Chlorpromazine	26477383
C012255	clobazam	CYP2C18 protein results in increased metabolism of clobazam	28243904
D002994	Clofibrate	Clofibrate results in decreased expression of CYP2C18 mRNA	19952500
D003033	Coal Tar	Coal Tar results in increased expression of CYP2C18 mRNA	16882163
D003520	Cyclophosphamide	CYP2C18 results in increased activity of Cyclophosphamide	9241661
D003520	Cyclophosphamide	CYP2C18 results in increased susceptibility to Cyclophosphamide	9766669
D003520	Cyclophosphamide	POR promotes the reaction [CYP2C18 results in increased susceptibility to Cyclophosphamide]	9766669
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYP2C18 mRNA	20106945
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of CYP2C18 mRNA	26924002
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of CYP2C18 mRNA	26924002
D005978	Glutathione	[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac	24246759
D005978	Glutathione	[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac	24246759
D007069	Ifosfamide	CYP2C18 results in increased activity of Ifosfamide	9241661
D007069	Ifosfamide	CYP2C18 results in increased metabolism of Ifosfamide	15301741
D007069	Ifosfamide	CYP2C18 results in increased susceptibility to Ifosfamide	15301741\|9766669
D007069	Ifosfamide	POR promotes the reaction [CYP2C18 results in increased susceptibility to Ifosfamide]	9766669
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CYP2C18 mRNA	26752646
D064747	Lansoprazole	CYP2C18 protein results in increased hydroxylation of Lansoprazole	7870052
D008731	Methoxychlor	CYP2C18 protein results in decreased methylation of Methoxychlor	9733665
D009853	Omeprazole	Omeprazole results in increased expression of CYP2C18 protein	16714371
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of CYP2C18 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CYP2C18 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP2C18 mRNA	17560707\|1916217
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP2C18 protein	9972451
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP2C18 protein	16714371
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP2C18 mRNA	23557933
D011374	Progesterone	Progesterone results in decreased expression of CYP2C18 mRNA	18070364
D011374	Progesterone	Progesterone results in increased expression of CYP2C18 mRNA	19690047
C005556	propionaldehyde	propionaldehyde results in increased expression of CYP2C18 mRNA	26079696
D012293	Rifampin	Rifampin results in decreased expression of CYP2C18 mRNA	22258563
C089730	rosiglitazone	rosiglitazone results in decreased expression of CYP2C18 mRNA	25572481
C009237	senecionine	senecionine results in decreased expression of CYP2C18 mRNA	26100227
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CYP2C18 mRNA	25351596
C001873	sporidesmin	MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]	28193462
C001873	sporidesmin	MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]	28193462
C001873	sporidesmin	sporidesmin results in increased expression of CYP2C18 mRNA	28193462
C001873	sporidesmin	sporidesmin results in increased expression of CYP2C18 protein	28193462
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP2C18 mRNA	16985168
D014044	Tolbutamide	CYP2C18 results in increased metabolism of Tolbutamide	15301741
D014212	Tretinoin	Tretinoin results in decreased expression of CYP2C18 mRNA	16985168
C060523	vorozole	vorozole results in increased expression of CYP2C18 protein	16714371
C574123	walrycin A	walrycin A results in increased expression of CYP2C18 mRNA	22314385
D014859	Warfarin	CYP2C18 gene polymorphism affects the susceptibility to Warfarin	19752777
D014859	Warfarin	CYP2C18 protein affects the susceptibility to Warfarin	19752777

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004497	monooxygenase activity	-	TAS	-
GO:0005506	iron ion binding	-	IEA	-
GO:0008392	arachidonic acid epoxygenase activity	-	IBA	21873635
GO:0008395	steroid hydroxylase activity	-	IBA	21873635
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	-	IBA	21873635
GO:0019825	oxygen binding	-	TAS	8110777
GO:0020037	heme binding	-	IBA	21873635
GO:0020037	heme binding	-	IEA	-
GO:0070330	aromatase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006082	organic acid metabolic process	-	IBA	21873635
GO:0006805	xenobiotic metabolic process	-	IBA	21873635
GO:0006805	xenobiotic metabolic process	-	TAS	-
GO:0042738	exogenous drug catabolic process	-	IBA	21873635
GO:0055114	oxidation-reduction process	-	IBA	21873635
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0031090	organelle membrane	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635

KEGG ID	KEGG Term
hsa00590	Arachidonic acid metabolism
hsa00591	Linoleic acid metabolism
hsa00830	Retinol metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-211981	Xenobiotics	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26095139	Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)	Toselli F	Xenobiotica