| C013567 | 10-hydroxynortriptyline | CYP2D6 gene mutant form results in increased abundance of 10-hydroxynortriptyline | 11673748 |
| C013567 | 10-hydroxynortriptyline | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of 10-hydroxynortriptyline] | 11673748 |
| C013567 | 10-hydroxynortriptyline | CYP2D6 affects the chemical synthesis of 10-hydroxynortriptyline | 18359183 |
| C495657 | 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane | "CYP2D6 protein results in increased hydroxylation of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane" | 9047321 |
| C026486 | 1,2,5,6-dibenzanthracene | "1,2,5,6-dibenzanthracene results in increased expression of CYP2D6 mRNA" | 16269432 |
| C517214 | 12-hydroxyellipticine | CYP2D6 protein mutant form results in increased chemical synthesis of 12-hydroxyellipticine | 22917556 |
| C439392 | 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline | "CYP2D6 protein results in decreased methylation of 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline" | 15585365 |
| C516975 | 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine | 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine results in decreased activity of CYP2D6 protein | 21634396 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | [NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C015068 | 1-(3-chlorophenyl)piperazine | CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine | 18238857 |
| C015068 | 1-(3-chlorophenyl)piperazine | Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine] | 18238857 |
| C015068 | 1-(3-chlorophenyl)piperazine | CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine | 8885123 |
| C517215 | 13-hydroxyellipticine | CYP2D6 protein mutant form results in increased chemical synthesis of 13-hydroxyellipticine | 22917556 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "CYP2D6 protein results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "CYP2D6 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP2D6 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene metabolite" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP2D6 protein results in increased metabolism of N,N-didesmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP2D6 protein results in increased metabolism of Tamoxifen] which results in decreased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C035342 | 1,4-naphthoquinone | "CYP2D6 protein results in increased abundance of 1,4-naphthoquinone" | 16243959 |
| C558737 | 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea | "1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea results in decreased activity of CYP2D6 protein" | 21341682 |
| C486136 | 16-O-demethylaconitine | [CYP2D6 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| C486136 | 16-O-demethylaconitine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| C033020 | 1-aminobenzotriazole | 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] | 15618748 |
| C012376 | 1'-hydroxysafrole | [CYP2D6 protein results in increased metabolism of Safrole] which results in increased abundance of 1'-hydroxysafrole | 20507880 |
| C029350 | 1-naphthol | CYP2D6 protein results in increased abundance of 1-naphthol | 16243959 |
| C024336 | 1-phenylazo-2-naphthol | CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] | 17159775 |
| C024336 | 1-phenylazo-2-naphthol | CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol | 17159775 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | "2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in decreased activity of CYP2D6 protein" | 25542188 |
| C077584 | 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine | "[CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine" | 17279779 |
| C049584 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | "CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine" | 17279779 |
| C049584 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | "[CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine" | 17279779 |
| C003898 | 2-anisidine | CYP2D6 protein results in increased oxidation of 2-anisidine | 15828049 |
| C586542 | 2'-(glutathion-S-yl)-deschlorodiclofenac | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac | 24246759 |
| C051268 | 2-hydroxychavicol | [CYP2D6 protein results in increased metabolism of Eugenol] which results in increased abundance of 2-hydroxychavicol | 15576237 |
| C109602 | 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate | "3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate results in decreased activity of CYP2D6 protein" | 16049129 |
| C437963 | 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin | "3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein" | 20345925 |
| C437963 | 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin | "Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]" | 20345925 |
| C016834 | 3,5-xylenol | "CYP2D6 protein results in increased oxidation of 3,5-xylenol analog" | 27665777 |
| C016834 | 3,5-xylenol | "[CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog" | 27665777 |
| C028657 | 3-methoxymorphinan | CYP2D6 protein affects the metabolism of 3-methoxymorphinan | 15988119 |
| C028657 | 3-methoxymorphinan | CYP2D6 protein results in increased metabolism of 3-methoxymorphinan | 21606622 |
| C028657 | 3-methoxymorphinan | [CYP2D6 protein results in increased metabolism of 3-methoxymorphinan] which results in increased chemical synthesis of norlevorphanol | 21606622 |
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | CYP2D6 protein affects the susceptibility to ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | 24122908 |
| C545880 | 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide | "CYP2D6 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide" | 19697924 |
| C032642 | 4-aminophenylarsenoxide | 4-aminophenylarsenoxide binds to CYP2D6 protein | 26598702 |
| C032642 | 4-aminophenylarsenoxide | arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP2D6 protein] | 26598702 |
| C032538 | 4-cresol | CYP2D6 protein results in increased metabolism of 4-cresol | 16174805 |
| C108036 | 4'-hydroxydiclofenac | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac | 24246759 |
| C108036 | 4'-hydroxydiclofenac | [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac | 24246759 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | CYP2D6 gene polymorphism affects the abundance of 4-hydroxy-N-desmethyltamoxifen | 14652237 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen | 29285606 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | [CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen] which results in increased abundance of 4-hydroxy-N-desmethyltamoxifen metabolite | 29285606 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of 4-hydroxy-N-desmethyltamoxifen | 29285606 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased abundance of 4-hydroxy-N-desmethyltamoxifen | 14652237 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen | 14652237 |
| C001422 | 4-hydroxypropranolol | CYP2D6 protein results in increased chemical synthesis of 4-hydroxypropranolol | 21184751 |
| C001470 | 4-ipomeanol | CYP2D6 protein results in increased activity of 4-ipomeanol | 15892579 |
| C044390 | 4-(methylsulfinyl)phenol | CYP2D6 protein results in increased abundance of 4-(methylsulfinyl)phenol analog | 27665777 |
| C044390 | 4-(methylsulfinyl)phenol | "[CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog" | 27665777 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | CYP2D6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 2070484 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | CYP2D6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 25221795 |
| C040997 | 5-bromotryptamine | 5-bromotryptamine analog results in decreased activity of CYP2D6 protein | 26599973 |
| C040997 | 5-bromotryptamine | [5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C529169 | 5-chlorotryptamine | 5-chlorotryptamine analog results in decreased activity of CYP2D6 protein | 26599973 |
| C529169 | 5-chlorotryptamine | [5-chlorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C051101 | 5-fluoro-alpha-methyltryptamine | 5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2D6 protein | 26599973 |
| C051101 | 5-fluoro-alpha-methyltryptamine | [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C051101 | 5-fluoro-alpha-methyltryptamine | 5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2D6 protein | 26599973 |
| C051101 | 5-fluoro-alpha-methyltryptamine | [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C034536 | 5-fluorotryptamine | 5-fluorotryptamine analog results in decreased activity of CYP2D6 protein | 26599973 |
| C034536 | 5-fluorotryptamine | [5-fluorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C117715 | 5-hydroxydiclofenac | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac | 24246759 |
| C542024 | 5-hydroxypropranolol | CYP2D6 protein results in increased chemical synthesis of 5-hydroxypropranolol | 21184751 |
| C487413 | 5-methoxyindole | 5-methoxyindole results in decreased activity of CYP2D6 protein | 18420780 |
| C033696 | 5-methoxy-N,N-diisopropyltryptamine | "5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein" | 26599973 |
| C033696 | 5-methoxy-N,N-diisopropyltryptamine | "[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan" | 26599973 |
| C027552 | 5-methyltryptamine | 5-methyltryptamine analog results in decreased activity of CYP2D6 protein | 26599973 |
| C027552 | 5-methyltryptamine | [5-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C547858 | 5-n-butyl-pyrazolo(1,5-a)pyrimidine | "5-n-butyl-pyrazolo(1,5-a)pyrimidine metabolite binds to CYP2D6 protein" | 19928966 |
| C002272 | 6-methoxytryptoline | CYP2D6 protein binds to and results in decreased methylation of 6-methoxytryptoline | 12777961 |
| C081382 | 7-hydroxyloxapine | CYP2D6 results in increased chemical synthesis of 7-hydroxyloxapine | 21826677 |
| C120605 | 7-methoxy-4-(aminomethyl)coumarin | CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin | 23850985 |
| C120605 | 7-methoxy-4-(aminomethyl)coumarin | [CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins | 23850985 |
| C120605 | 7-methoxy-4-(aminomethyl)coumarin | Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins] | 23850985 |
| C556297 | 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | "[CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine" | 20825217 |
| C036696 | 7-methyltryptamine | 7-methyltryptamine analog results in decreased activity of CYP2D6 protein | 26599973 |
| C036696 | 7-methyltryptamine | [7-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C067134 | 8-oxo-7-hydrodeoxyguanosine | [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine | 15576237 |
| C421010 | 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole | "CYP2D6 protein results in increased chemical synthesis of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole" | 15279827 |
| D000157 | Aconitine | CYP2D6 protein results in increased metabolism of Aconitine | 21277363 |
| D000157 | Aconitine | [CYP2D6 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| D000157 | Aconitine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite | 21277363 |
| C499366 | Active Hexose Correlated Compound | Active Hexose Correlated Compound results in increased expression of CYP2D6 | 19087767 |
| C499366 | Active Hexose Correlated Compound | CYP2D6 protein results in increased metabolism of Active Hexose Correlated Compound | 19087767 |
| C016601 | afimoxifene | CYP2D6 protein results in increased metabolism of afimoxifene | 29285606 |
| C016601 | afimoxifene | [CYP2D6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite | 29285606 |
| C016601 | afimoxifene | CYP2D6 protein results in increased abundance of afimoxifene | 26530625 |
| C016601 | afimoxifene | [CYP2D6 protein results in increased hydroxylation of Tamoxifen] which results in increased abundance of afimoxifene | 26530625 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased methylation of CYP2D6 gene | 27153756 |
| D016604 | Aflatoxin B1 | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B1 | 23397584 |
| D000393 | Air Pollutants | Air Pollutants results in increased expression of CYP2D6 mRNA | 21757418 |
| C409045 | almotriptan | CYP2D6 protein results in decreased methylation of almotriptan | 12642466 |
| C409045 | almotriptan | CYP2D6 protein results in increased hydroxylation of almotriptan | 12642466 |
| C023492 | alpha-methyldopamine | "[CYP2D6 protein results in increased metabolism of and results in decreased methylation of 3,4-Methylenedioxyamphetamine] which results in increased chemical synthesis of alpha-methyldopamine" | 19576971 |
| D000634 | Aminoquinolines | Aminoquinolines results in decreased activity of CYP2D6 protein | 18563832 |
| D000638 | Amiodarone | Amiodarone results in decreased activity of CYP2D6 protein | 16449812 |
| D000638 | Amiodarone | Amiodarone results in increased expression of CYP2D6 mRNA | 19774075 |
| D000638 | Amiodarone | CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol] | 15541258 |
| D000639 | Amitriptyline | Amitriptyline results in decreased activity of CYP2D6 protein | 18359183 |
| D000639 | Amitriptyline | Amitriptyline results in increased metabolism of CYP2D6 protein | 18359012 |
| D000639 | Amitriptyline | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline | 23397584 |
| D000639 | Amitriptyline | CYP2D6 protein results in increased metabolism of Amitriptyline | 16044105|2732096 |
| C006566 | amitriptyline N-oxide | CYP2D6 protein results in increased abundance of amitriptyline N-oxide | 27320963 |
| D000655 | Amodiaquine | CYP2D6 protein results in increased metabolism of Amodiaquine | 28478157 |
| D000655 | Amodiaquine | [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| C094705 | amodiaquine quinoneimine | CYP2D6 protein results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| C094705 | amodiaquine quinoneimine | [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| D000661 | Amphetamine | CYP2D6 protein affects the chemical synthesis of Amphetamine | 15294457 |
| D000662 | Amphetamines | CYP2D6 protein results in increased metabolism of Amphetamines | 10911933 |
| C023650 | aniline | CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] | 15279827 |
| D016718 | Arachidonic Acid | CYP2D6 protein results in increased metabolism of Arachidonic Acid | 12675279 |
| D001095 | Arachidonic Acids | CYP2D6 protein results in increased chemical synthesis of Arachidonic Acids metabolite | 12675279 |
| D000068180 | Aripiprazole | CYP2D6 protein affects the metabolism of Aripiprazole | 17110829|1848069 |
| C006632 | arsenic trioxide | arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP2D6 protein] | 26598702 |
| D000069445 | Atomoxetine Hydrochloride | CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride | 17470523 |
| C002478 | bathocuproine | bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| C061004 | benidipine | benidipine results in decreased activity of CYP2D6 protein | 10805063 |
| D001554 | Benzene | CYP2D6 gene polymorphism results in increased susceptibility to Benzene | 16737584|1747940 |
| D001554 | Benzene | CYP2D6 protein results in increased metabolism of Benzene | 17479406 |
| C006703 | benzo(b)fluoranthene | benzo(b)fluoranthene results in increased expression of CYP2D6 mRNA | 16269432 |
| D019324 | beta-Naphthoflavone | beta-Naphthoflavone results in decreased expression of CYP2D6 mRNA | 22258563 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of CYP2D6 mRNA | 16269432 |
| D003374 | Coumarins | [CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins | 23850985 |
| D003374 | Coumarins | Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins] | 23850985 |
| C006780 | bisphenol A | CYP2D6 protein results in increased metabolism of bisphenol A | 21402134 |
| C006780 | bisphenol A | [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone | 21402134 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of CYP2D6 mRNA | 25181051 |
| D000069286 | Bortezomib | CYP2D6 protein affects the metabolism of Bortezomib | 15764713 |
| C010831 | bufuralol | CYP2D6 protein affects the metabolism of bufuralol | 15801540 |
| C010831 | bufuralol | 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] | 15618748 |
| C010831 | bufuralol | CYP2D6 protein affects the metabolism of bufuralol | 15801540 |
| C010831 | bufuralol | CYP2D6 protein results in increased hydrolysis of bufuralol | 11377097 |
| C010831 | bufuralol | CYP2D6 protein results in increased hydroxylation of bufuralol | 10933885|1243379 |
| C010831 | bufuralol | CYP2D6 protein results in increased metabolism of bufuralol | 12401345|1246424 |
| C010831 | bufuralol | [CYP2D6 protein results in increased metabolism of bufuralol] which results in increased chemical synthesis of Ro 03-7410 | 25084468 |
| C010831 | bufuralol | CYP2D6 protein results in increased oxidation of bufuralol | 21964418 |
| C010831 | bufuralol | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]" | 16049126 |
| C010831 | bufuralol | perfluorooctane sulfonic acid inhibits the reaction [CYP2D6 protein results in increased oxidation of bufuralol] | 21964418 |
| C010831 | bufuralol | Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol] | 11377097 |
| C010831 | bufuralol | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol] | 12569440 |
| C010831 | bufuralol | rabeprazole-thioether inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] | 15258107 |
| C010831 | bufuralol | CYP2D6 protein affects the metabolism of bufuralol | 15801540 |
| D002047 | Buprenorphine | Buprenorphine results in decreased activity of CYP2D6 protein | 12756210 |
| D002047 | Buprenorphine | CYP2D6 protein results in increased metabolism of Buprenorphine | 12756210 |
| D002065 | Buspirone | CYP2D6 protein results in increased oxidation of Buspirone | 15640381 |
| D002110 | Caffeine | CYP2D6 protein affects the metabolism of Caffeine | 15199075 |
| D002185 | Cannabidiol | Cannabidiol results in decreased activity of CYP2D6 protein | 24667653 |
| D002211 | Capsaicin | Capsaicin results in decreased activity of CYP2D6 protein | 22375877 |
| D002220 | Carbamazepine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Carbamazepine | 23397584 |
| C006698 | carbendazim | carbendazim results in decreased activity of CYP2D6 protein | 20183062 |
| C043211 | carvedilol | CYP2D6 gene polymorphism affects the glucuronidation of carvedilol | 16849011 |
| C043211 | carvedilol | CYP2D6 gene polymorphism affects the metabolism of carvedilol | 16595916|1684901 |
| C043211 | carvedilol | CYP2D6 gene polymorphism affects the susceptibility to carvedilol | 20643254 |
| C043211 | carvedilol | CYP2D6 protein polymorphism affects the metabolism of carvedilol | 15001973|2159957 |
| C088453 | Celsior | Celsior results in decreased expression of CYP2D6 mRNA | 15448115 |
| D002738 | Chloroquine | CYP2D6 protein affects the metabolism of Chloroquine | 12920490 |
| D002744 | Chlorpheniramine | CYP2D6 mutant form results in increased susceptibility to Chlorpheniramine | 17089107 |
| D002746 | Chlorpromazine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine | 23397584 |
| D002746 | Chlorpromazine | CYP2D6 protein results in decreased susceptibility to Chlorpromazine | 26477383 |
| D002746 | Chlorpromazine | CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine | 19482014 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in decreased activity of CYP2D6 protein | 20183062 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased expression of CYP2D6 mRNA | 16757081 |
| D004390 | Chlorpyrifos | CYP2D6 protein results in increased oxidation of Chlorpyrifos | 14979094 |
| D004390 | Chlorpyrifos | Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] | 14979094 |
| D002927 | Cimetidine | Cimetidine results in decreased activity of CYP2D6 protein | 19909766 |
| D002927 | Cimetidine | styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] | 19909766 |
| D002927 | Cimetidine | Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 17651725 |
| D002927 | Cimetidine | Cimetidine results in decreased activity of CYP2D6 protein | 17651725 |
| D000069449 | Cinacalcet Hydrochloride | Cinacalcet Hydrochloride results in decreased activity of CYP2D6 protein | 16680561 |
| C029010 | cinnamic acid | cinnamic acid analog results in decreased activity of CYP2D6 protein | 15072549 |
| D015283 | Citalopram | CYP2D6 protein results in decreased methylation of Citalopram analog | 9110356 |
| D015283 | Citalopram | CYP2D6 protein affects the metabolism of Citalopram | 16702909 |
| D002997 | Clomipramine | CYP2D6 protein affects the metabolism of Clomipramine | 10353456 |
| C055162 | clopidogrel | CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite | 19170597 |
| D003024 | Clozapine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine | 23397584 |
| D003024 | Clozapine | CYP2D6 protein affects the metabolism of Clozapine | 15286053 |
| D003024 | Clozapine | CYP2D6 protein results in increased metabolism of Clozapine | 18809730|2732096 |
| D003024 | Clozapine | CYP2D6 protein affects the metabolism of Clozapine | 9812137 |
| C079149 | clozapine N-oxide | CYP2D6 protein results in increased abundance of clozapine N-oxide | 27320963 |
| C079149 | clozapine N-oxide | CYP2D6 protein results in increased chemical synthesis of clozapine N-oxide | 18809730 |
| D003061 | Codeine | [CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine | 21241245|2124124 |
| D003061 | Codeine | CYP2D6 gene polymorphism results in increased metabolism of Codeine | 17564651 |
| D003061 | Codeine | CYP2D6 protein affects the metabolism of Codeine | 15286053|1562533 |
| D003061 | Codeine | CYP2D6 protein polymorphism affects the metabolism of Codeine | 11823760 |
| D003061 | Codeine | CYP2D6 protein polymorphism affects the susceptibility to Codeine | 9696456 |
| D003061 | Codeine | CYP2D6 protein results in decreased methylation of Codeine | 17470523 |
| D003061 | Codeine | CYP2D6 protein results in increased metabolism of Codeine | 10911933|1659571 |
| D003061 | Codeine | [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine | 16595712|2124124 |
| D009249 | NADP | "[CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine" | 20825217 |
| D009249 | NADP | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | [NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | 24120545 |
| D009249 | NADP | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D003300 | Copper | bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| D003300 | Copper | CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| D003300 | Copper | [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol | 15576237 |
| D003300 | Copper | [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine | 15576237 |
| D003300 | Copper | methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| D003505 | Cyclodextrins | Cyclodextrins analog results in decreased activity of CYP2D6 protein | 15665498 |
| D003520 | Cyclophosphamide | CYP2D6 protein results in increased metabolism of Cyclophosphamide | 11377097 |
| C037304 | cyhalothrin | cyhalothrin results in decreased activity of CYP2D6 protein | 20183062 |
| C017160 | cypermethrin | cypermethrin results in decreased activity of CYP2D6 protein | 18420780 |
| C004742 | daidzein | daidzein results in decreased activity of CYP2D6 protein | 18420780 |
| D003647 | Debrisoquin | CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin | 11673748 |
| D003647 | Debrisoquin | CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin | 8946814 |
| D003647 | Debrisoquin | CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin | 11673748 |
| D003647 | Debrisoquin | CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite | 11673748 |
| D003647 | Debrisoquin | CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin | 6603386 |
| D003647 | Debrisoquin | CYP2D6 protein affects the metabolism of Debrisoquin | 3577206 |
| D003647 | Debrisoquin | CYP2D6 protein polymorphism affects the metabolism of Debrisoquin | 11823760 |
| D003647 | Debrisoquin | CYP2D6 protein results in increased hydroxylation of Debrisoquin | 17470523 |
| D003647 | Debrisoquin | CYP2D6 protein results in increased metabolism of Debrisoquin | 12464242 |
| D003647 | Debrisoquin | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin] | 11673748 |
| D003647 | Debrisoquin | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite] | 11673748 |
| C017180 | decamethrin | decamethrin results in decreased activity of CYP2D6 protein | 20183062 |
| D003671 | DEET | CYP2D6 protein results in increased metabolism of DEET | 11854147 |
| C047386 | desethylamodiaquine | CYP2D6 protein results in increased metabolism of desethylamodiaquine | 28478157 |
| C007278 | desethylchloroquine | desethylchloroquine results in decreased activity of CYP2D6 protein | 11124226 |
| D003891 | Desipramine | CYP2D6 protein affects the metabolism of Desipramine | 15286053 |
| D003891 | Desipramine | CYP2D6 protein affects the metabolism of Desipramine | 15172931 |
| C121345 | desloratadine | CYP2D6 protein affects the chemical synthesis of desloratadine | 15932952 |
| D000069468 | Desvenlafaxine Succinate | CYP2D6 protein results in increased abundance of Desvenlafaxine Succinate | 21840145 |
| D000069468 | Desvenlafaxine Succinate | [CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of Desvenlafaxine Succinate | 21840145 |
| D000069468 | Desvenlafaxine Succinate | "[[CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of Desvenlafaxine Succinate] which results in increased abundance of N,O-didesmethylvenlafaxine" | 21840145 |
| D003917 | Dextrorphan | CYP2D6 protein affects the chemical synthesis of Dextrorphan | 15988119 |
| D003917 | Dextrorphan | CYP2D6 protein results in increased chemical synthesis of Dextrorphan | 15155557|2385098 |
| D003917 | Dextrorphan | CYP2D6 affects the chemical synthesis of Dextrorphan | 18359183 |
| D003917 | Dextrorphan | [CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan | 21606622 |
| D036381 | Diarylheptanoids | Diarylheptanoids results in decreased activity of CYP2D6 protein | 23850985 |
| D003976 | Diazinon | Diazinon results in increased expression of CYP2D6 mRNA | 16757081 |
| D004008 | Diclofenac | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac | 23397584 |
| D004008 | Diclofenac | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac | 24246759 |
| D004008 | Diclofenac | [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac | 24246759 |
| C036042 | dicyclohexyl phthalate | dicyclohexyl phthalate results in increased expression of CYP2D6 mRNA | 26924002 |
| C012906 | dihydrocapsaicin | dihydrocapsaicin results in decreased activity of CYP2D6 protein | 22375877 |
| D004087 | Dihydroergotamine | Dihydroergotamine results in decreased activity of CYP2D6 protein | 18420780 |
| C012621 | dimemorfan | CYP2D6 protein results in increased oxidation of dimemorfan | 19593786 |
| C012621 | dimemorfan | Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan] | 19593786 |
| C066888 | dimethocaine | CYP2D6 protein results in increased hydroxylation of dimethocaine | 24309420 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "CYP2D6 protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene" | 20507880 |
| C024629 | dimethyl phthalate | dimethyl phthalate results in increased expression of CYP2D6 mRNA | 26924002 |
| D004121 | Dimethyl Sulfoxide | Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein] | 11368792 |
| D004121 | Dimethyl Sulfoxide | Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] | 11368792 |
| D004121 | Dimethyl Sulfoxide | Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] | 11368792 |
| C067311 | docetaxel | CYP2D6 gene SNP affects the susceptibility to docetaxel | 23758476 |
| D004294 | Domperidone | CYP2D6 protein results in increased hydroxylation of Domperidone | 15327587 |
| D004298 | Dopamine | CYP2D6 protein results in increased abundance of Dopamine | 26763401 |
| D004298 | Dopamine | [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine | 26763401 |
| D004298 | Dopamine | Dopamine results in decreased activity of CYP2D6 protein | 18420780 |
| D000068736 | Duloxetine Hydrochloride | CYP2D6 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride | 20669986 |
| D000068736 | Duloxetine Hydrochloride | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride | 20669986 |
| C034192 | ellipticine | CYP2D6 protein mutant form results in increased metabolism of ellipticine | 22917556 |
| D004977 | Ethambutol | Ethambutol results in decreased activity of CYP2D6 protein | 24910189 |
| D005054 | Eugenol | bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| D005054 | Eugenol | CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| D005054 | Eugenol | [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol | 15576237 |
| D005054 | Eugenol | CYP2D6 protein results in increased metabolism of Eugenol | 15576237 |
| D005054 | Eugenol | [CYP2D6 protein results in increased metabolism of Eugenol] which results in increased abundance of 2-hydroxychavicol | 15576237 |
| D005054 | Eugenol | [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine | 15576237 |
| D005054 | Eugenol | methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| C103110 | eupatorin | eupatorin results in decreased activity of CYP2D6 protein | 21276781 |
| C026013 | fenproporex | CYP2D6 protein results in decreased alkylation of fenproporex | 15294457 |
| C017690 | fenvalerate | fenvalerate results in decreased activity of CYP2D6 protein | 20183062 |
| D005473 | Fluoxetine | CYP2D6 gene mutant form results in decreased metabolism of Fluoxetine | 10755579 |
| D005473 | Fluoxetine | CYP2D6 gene polymorphism affects the abundance of Fluoxetine | 14726986 |
| D005473 | Fluoxetine | CYP2D6 gene polymorphism affects the metabolism of Fluoxetine | 14639062|1471670 |
| D005473 | Fluoxetine | CYP2D6 protein affects the abundance of Fluoxetine | 15094477 |
| D005473 | Fluoxetine | CYP2D6 protein affects the metabolism of Fluoxetine | 15286053|1623614 |
| D005473 | Fluoxetine | CYP2D6 protein affects the susceptibility to Fluoxetine | 15172931 |
| D005473 | Fluoxetine | CYP2D6 protein results in decreased methylation of Fluoxetine | 17470523 |
| D005473 | Fluoxetine | CYP2D6 protein results in increased metabolism of Fluoxetine | 10755579|1463906 |
| D005473 | Fluoxetine | Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] | 10583026 |
| D005473 | Fluoxetine | Fluoxetine results in decreased activity of CYP2D6 protein | 12173784|1659571 |
| D005473 | Fluoxetine | [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D005473 | Fluoxetine | CYP2D6 affects the metabolism of Fluoxetine | 11304903 |
| D005473 | Fluoxetine | [CYP2D6 affects the metabolism of Fluoxetine] which results in increased chemical synthesis of norfluoxetine | 11304903 |
| D005473 | Fluoxetine | CYP2D6 protein affects the metabolism of Fluoxetine | 11673748|1517293 |
| D005473 | Fluoxetine | Fluoxetine results in decreased activity of CYP2D6 protein | 11145498|1568747 |
| D005485 | Flutamide | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide | 23397584 |
| D016666 | Fluvoxamine | CYP2D6 protein affects the metabolism of Fluvoxamine | 11673748 |
| C007768 | formononetin | formononetin results in decreased activity of CYP2D6 protein | 26278343 |
| C419708 | gefitinib | CYP2D6 protein affects the metabolism of gefitinib | 15788367 |
| C048393 | germacrone | germacrone results in decreased activity of CYP2D6 protein | 23850985 |
| D005978 | Glutathione | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac | 24246759 |
| D005978 | Glutathione | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac | 24246759 |
| D005978 | Glutathione | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac | 24246759 |
| D005978 | Glutathione | [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac | 24246759 |
| D005978 | Glutathione | [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac | 24246759 |
| D005978 | Glutathione | "[CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine" | 20825217 |
| D006046 | Gold | [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA | 28433809 |
| D006220 | Haloperidol | CYP2D6 protein polymorphism affects the susceptibility to Haloperidol | 15538130 |
| D006427 | Hemin | Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] | 11368792 |
| D006427 | Hemin | Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein] | 11368792 |
| D006427 | Hemin | Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] | 11368792 |
| D006861 | Hydrogen Peroxide | CYP2D6 protein results in increased abundance of Hydrogen Peroxide | 25061110 |
| C031927 | hydroquinone | [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone | 21402134 |
| D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors | CYP2D6 gene polymorphism results in increased metabolism of Hydroxymethylglutaryl-CoA Reductase Inhibitors | 17289397 |
| C010471 | hyodeoxycholic acid | [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid | 18039809 |
| C058309 | hypaconitine | CYP2D6 protein results in increased metabolism of hypaconitine | 21550385 |
| C058468 | ICI 199441 | ICI 199441 results in decreased activity of CYP2D6 protein | 15863335 |
| D007069 | Ifosfamide | CYP2D6 protein results in increased susceptibility to Ifosfamide | 20507880 |
| D007099 | Imipramine | CYP2D6 protein affects the metabolism of Imipramine | 15286053 |
| D007099 | Imipramine | CYP2D6 protein affects the metabolism of Imipramine | 15687478 |
| C002921 | imipramine N-oxide | CYP2D6 protein results in increased abundance of imipramine N-oxide | 27320963 |
| C489645 | indomethacin phenethylamide | CYP2D6 protein results in increased metabolism of indomethacin phenethylamide | 14709628 |
| C015293 | indopan | indopan analog results in decreased activity of CYP2D6 protein | 26599973 |
| C015293 | indopan | [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| C015293 | indopan | indopan results in decreased activity of CYP2D6 protein | 26599973 |
| C015293 | indopan | [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D007510 | Isatin | Isatin results in increased expression of CYP2D6 mRNA | 15056799 |
| C549713 | isocarbophos | CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos | 24752505 |
| C055542 | isoimperatorin | CYP2D6 protein results in increased oxidation of isoimperatorin | 25500267 |
| C028904 | isoproturon | isoproturon results in decreased activity of CYP2D6 protein | 18420780 |
| D007559 | Ivermectin | Ivermectin results in decreased activity of CYP2D6 protein | 11124226|1842078 |
| D007654 | Ketoconazole | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] | 19230594 |
| D007654 | Ketoconazole | Ketoconazole results in decreased activity of CYP2D6 protein | 15618748 |
| D007654 | Ketoconazole | Ketoconazole results in decreased activity of CYP2D6 protein | 18420780 |
| C047781 | lamotrigine | CYP2D6 protein results in increased glutathionylation of lamotrigine | 19961160 |
| C011896 | lephetamine | CYP2D6 protein results in decreased alkylation of lephetamine | 26276083 |
| C070840 | licochalcone A | licochalcone A affects the activity of CYP2D6 protein | 26100226 |
| D001556 | Lindane | Lindane results in decreased expression of CYP2D6 mRNA | 20035023 |
| D008095 | Lithocholic Acid | CYP2D6 protein results in increased metabolism of Lithocholic Acid | 18039809 |
| D008095 | Lithocholic Acid | [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid | 18039809 |
| D017336 | Loratadine | CYP2D6 gene polymorphism affects the metabolism of Loratadine | 15932952 |
| D017336 | Loratadine | CYP2D6 protein affects the metabolism of Loratadine | 15932952 |
| D008152 | Loxapine | CYP2D6 results in increased metabolism of Loxapine | 21826677 |
| D008345 | Manganese | CYP2D6 gene polymorphism results in decreased susceptibility to Manganese | 12171760 |
| C501277 | Mangifera indica extract | Mangifera indica extract results in decreased activity of CYP2D6 protein | 22815239 |
| C013592 | mangiferin | mangiferin results in decreased activity of CYP2D6 protein | 22815239 |
| C054218 | manidipine | manidipine results in decreased activity of CYP2D6 protein | 10805063 |
| D008549 | Melarsoprol | Melarsoprol results in decreased activity of CYP2D6 protein | 11124226 |
| C050699 | mepirodipine | mepirodipine results in decreased activity of CYP2D6 protein | 10805063 |
| C006069 | mequitazine | CYP2D6 protein results in increased hydroxylation of mequitazine | 15863898 |
| C006069 | mequitazine | Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] | 15863898 |
| D008691 | Methadone | Methadone results in decreased activity of CYP2D6 protein | 16595712 |
| D008691 | Methadone | CYP2D6 protein affects the metabolism of Methadone | 11145498 |
| D008691 | Methadone | Methadone results in decreased activity of CYP2D6 protein | 16089243 |
| D008694 | Methamphetamine | CYP2D6 protein affects the susceptibility to Methamphetamine | 18280655 |
| D008694 | Methamphetamine | CYP2D6 protein results in increased metabolism of Methamphetamine | 27320963 |
| D008694 | Methamphetamine | CYP2D6 protein results in increased degradation of Methamphetamine | 15289744 |
| C117950 | methamphetamine hydroxylamine | CYP2D6 protein results in increased abundance of methamphetamine hydroxylamine | 27320963 |
| D008714 | Methiocarb | CYP2D6 protein results in increased metabolism of Methiocarb | 27665777 |
| D008714 | Methiocarb | [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide | 27665777 |
| C097911 | methiocarb sulfoxide | CYP2D6 protein results in increased abundance of methiocarb sulfoxide | 27665777 |
| C097911 | methiocarb sulfoxide | [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide | 27665777 |
| C008390 | methional | methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] | 15576237 |
| D003915 | Dextromethorphan | [5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [5-chlorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [5-fluorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | "[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan" | 26599973 |
| D003915 | Dextromethorphan | [5-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [7-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan | 21228393 |
| D003915 | Dextromethorphan | CYP2D6 polymorphism affects the metabolism of Dextromethorphan | 18359183 |
| D003915 | Dextromethorphan | CYP2D6 protein affects the metabolism of Dextromethorphan | 14586384|1502574 |
| D003915 | Dextromethorphan | CYP2D6 protein polymorphism affects the metabolism of Dextromethorphan | 11823760|9429230 |
| D003915 | Dextromethorphan | CYP2D6 protein results in decreased methylation of Dextromethorphan | 12433797|1586389 |
| D003915 | Dextromethorphan | CYP2D6 protein results in increased metabolism of Dextromethorphan | 10911933|1515555 |
| D003915 | Dextromethorphan | [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | [Methoxydimethyltryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] | 15863898 |
| D003915 | Dextromethorphan | "[N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan" | 26599973 |
| D003915 | Dextromethorphan | "[N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan" | 26599973 |
| D003915 | Dextromethorphan | [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] | 15930738 |
| D003915 | Dextromethorphan | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 16595712|2385098 |
| D003915 | Dextromethorphan | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] | 15930738 |
| D003915 | Dextromethorphan | resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 20716633 |
| D003915 | Dextromethorphan | sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] | 24167220 |
| D003915 | Dextromethorphan | sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] | 24167220 |
| D003915 | Dextromethorphan | serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] | 15930738 |
| D003915 | Dextromethorphan | [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D003915 | Dextromethorphan | Dextromethorphan results in decreased activity of CYP2D6 protein | 18420780 |
| D003915 | Dextromethorphan | Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 17651725 |
| D003915 | Dextromethorphan | CYP2D6 protein results in increased metabolism of Dextromethorphan | 17651725 |
| D003915 | Dextromethorphan | ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 17651725 |
| D003915 | Dextromethorphan | CYP2D6 protein results in increased metabolism of Dextromethorphan | 16089243|2160662 |
| D003915 | Dextromethorphan | [CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan | 21606622 |
| D008728 | Methotrimeprazine | Methotrimeprazine results in decreased activity of CYP2D6 protein | 10954064 |
| D008731 | Methoxychlor | CYP2D6 protein results in decreased methylation of Methoxychlor | 12167570|1243379 |
| D008731 | Methoxychlor | Methoxychlor results in decreased activity of CYP2D6 protein | 18420780 |
| D008732 | Methoxydimethyltryptamines | CYP2D6 protein binds to and results in decreased methylation of Methoxydimethyltryptamines | 12777961 |
| D008732 | Methoxydimethyltryptamines | Methoxydimethyltryptamines analog results in decreased activity of CYP2D6 protein | 26599973 |
| D008732 | Methoxydimethyltryptamines | [Methoxydimethyltryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D008730 | Methoxsalen | Methoxsalen results in decreased activity of CYP2D6 protein | 18420780 |
| D008735 | 5-Methoxytryptamine | CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine | 12777961 |
| D015104 | 3,4-Methylenedioxyamphetamine | "CYP2D6 protein results in increased metabolism of and results in decreased methylation of 3,4-Methylenedioxyamphetamine" | 19576971 |
| D015104 | 3,4-Methylenedioxyamphetamine | "[CYP2D6 protein results in increased metabolism of and results in decreased methylation of 3,4-Methylenedioxyamphetamine] which results in increased chemical synthesis of alpha-methyldopamine" | 19576971 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "CYP2D6 protein results in increased metabolism of N-Methyl-3,4-methylenedioxyamphetamine" | 12464242 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]" | 16049126 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of CYP2D6 protein" | 16049126|2421153 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "CYP2D6 affects the metabolism of N-Methyl-3,4-methylenedioxyamphetamine" | 21871945 |
| D015632 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | "CYP2D6 protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" | 12464242 |
| D008787 | Metoclopramide | CYP2D6 gene polymorphism affects the metabolism of Metoclopramide | 16702617 |
| D008790 | Metoprolol | CYP2D6 gene affects the susceptibility to Metoprolol | 18648788|1878465 |
| D008790 | Metoprolol | CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol] | 15541258 |
| D008790 | Metoprolol | CYP2D6 gene polymorphism affects the susceptibility to Metoprolol | 12172215|1909444 |
| D008790 | Metoprolol | CYP2D6 protein affects the metabolism of Metoprolol | 15286053|1532758 |
| D008790 | Metoprolol | CYP2D6 protein polymorphism affects the metabolism of Metoprolol | 11823760 |
| D008790 | Metoprolol | CYP2D6 protein results in increased metabolism of Metoprolol | 12464242|1897909 |
| D008790 | Metoprolol | [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol | 10470702 |
| D008790 | Metoprolol | [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol | 10470702 |
| D008790 | Metoprolol | [terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] | 24894748 |
| D008790 | Metoprolol | YM 758 inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] | 19230594 |
| D008790 | Metoprolol | CYP2D6 protein results in increased metabolism of Metoprolol | 12172215|1909444 |
| D008790 | Metoprolol | Metoprolol results in decreased activity of CYP2D6 protein | 20345925 |
| D008874 | Midazolam | Midazolam results in decreased activity of CYP2D6 protein | 18420780 |
| C001801 | mitragynine | mitragynine results in increased expression of CYP2D6 protein | 23274770 |
| C517284 | monomethyl phthalate | monomethyl phthalate results in increased expression of CYP2D6 mRNA | 26924002 |
| D009020 | Morphine | CYP2D6 protein affects the chemical synthesis of Morphine | 15625333 |
| D009020 | Morphine | [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine | 16595712|2124124 |
| D018721 | Muscarinic Agonists | CYP2D6 protein affects the metabolism of Muscarinic Agonists | 16041192 |
| C534983 | N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropane | CYP2D6 protein results in increased metabolism of N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropane | 18425847 |
| C028473 | N-acetyl-4-benzoquinoneimine | CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine | 24661219 |
| C028473 | N-acetyl-4-benzoquinoneimine | CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine | 24552538 |
| C031721 | naphthalene | naphthalene results in increased expression of CYP2D6 mRNA | 20500019 |
| C012878 | N-desisopropylpropranolol | CYP2D6 protein results in increased chemical synthesis of N-desisopropylpropranolol | 21184751 |
| C028787 | N-desmethyltamoxifen | CYP2D6 protein results in increased abundance of N-desmethyltamoxifen | 29285606 |
| C028787 | N-desmethyltamoxifen | CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen | 29285606 |
| C028787 | N-desmethyltamoxifen | "[CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C028787 | N-desmethyltamoxifen | [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen | 29285606 |
| C028787 | N-desmethyltamoxifen | [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of N-desmethyltamoxifen | 29285606 |
| C028787 | N-desmethyltamoxifen | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen | 14652237 |
| C057222 | neferine | CYP2D6 protein results in increased glutathionylation of neferine metabolite | 25451576 |
| C057222 | neferine | CYP2D6 protein results in increased metabolism of and results in decreased methylation of neferine | 25451576 |
| C000598690 | N-ethyl-1,2-diphenylethylamine | "CYP2D6 protein results in decreased alkylation of N-ethyl-1,2-diphenylethylamine" | 26276083 |
| D009529 | Nicardipine | CYP2D6 protein affects the metabolism of Nicardipine | 15863898 |
| D009529 | Nicardipine | Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] | 15863898 |
| D009529 | Nicardipine | Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] | 15863898 |
| D009529 | Nicardipine | Nicardipine results in decreased activity of CYP2D6 protein | 10805063|1586389 |
| D009534 | Niclosamide | Niclosamide results in decreased activity of CYP2D6 protein | 11124226 |
| D009543 | Nifedipine | Nifedipine results in decreased activity of CYP2D6 protein | 18420780 |
| C012655 | nimesulide | CYP2D6 protein results in increased glutathionylation of nimesulide | 26524229 |
| C051570 | N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine | "CYP2D6 protein results in increased metabolism of and results in decreased methylation of N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine metabolite" | 19576971 |
| C468271 | N-methyl-N-benzylnitrosamine | N-methyl-N-benzylnitrosamine results in decreased activity of CYP2D6 protein | 12222751 |
| C578955 | N,N-diallyl-5-methoxytryptamine | "N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2D6 protein" | 26599973 |
| C578955 | N,N-diallyl-5-methoxytryptamine | "[N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan" | 26599973 |
| C574385 | N,N-didesmethyl-4-hydroxytamoxifen | "CYP2D6 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen" | 29285606 |
| C574385 | N,N-didesmethyl-4-hydroxytamoxifen | "[CYP2D6 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen] which results in increased abundance of N,N-didesmethyl-4-hydroxytamoxifen" | 29285606 |
| C122072 | N,N-didesmethyltamoxifen | "CYP2D6 protein results in increased metabolism of N,N-didesmethyltamoxifen" | 29285606 |
| C122072 | N,N-didesmethyltamoxifen | "[CYP2D6 protein results in increased metabolism of N,N-didesmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C454677 | N,N-diethyl-3-hydroxymethylbenzamide | "CYP2D6 protein results in increased chemical synthesis of N,N-diethyl-3-hydroxymethylbenzamide" | 11854147 |
| C033695 | N,N-diisopropyltryptamine | "N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein" | 26599973 |
| C033695 | N,N-diisopropyltryptamine | "[N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan" | 26599973 |
| C434333 | N,O-didesmethylvenlafaxine | "[[CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of Desvenlafaxine Succinate] which results in increased abundance of N,O-didesmethylvenlafaxine" | 21840145 |
| C043585 | norbuprenorphine | norbuprenorphine results in decreased activity of CYP2D6 protein | 12756210 |
| C058272 | norclozapine | CYP2D6 protein results in increased chemical synthesis of norclozapine | 18809730 |
| C036139 | norfluoxetine | [CYP2D6 affects the metabolism of Fluoxetine] which results in increased chemical synthesis of norfluoxetine | 11304903 |
| C010262 | norharman | CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] | 15279827 |
| C054116 | norlevorphanol | CYP2D6 protein affects the chemical synthesis of norlevorphanol | 15988119 |
| C054116 | norlevorphanol | [CYP2D6 protein results in increased metabolism of 3-methoxymorphinan] which results in increased chemical synthesis of norlevorphanol | 21606622 |
| D009661 | Nortriptyline | CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline | 11673748 |
| D009661 | Nortriptyline | CYP2D6 protein results in increased hydroxylation of Nortriptyline | 17470523 |
| D009661 | Nortriptyline | Nortriptyline results in increased metabolism of CYP2D6 protein | 18359012 |
| D009661 | Nortriptyline | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline] | 11673748 |
| C540176 | N-tert-butylisoquine | N-tert-butylisoquine results in decreased activity of CYP2D6 protein | 18563832 |
| C464660 | obeticholic acid | obeticholic acid results in increased expression of CYP2D6 mRNA | 27939613 |
| C080580 | O-demethyltramadol | CYP2D6 gene mutant form results in increased chemical synthesis of O-demethyltramadol | 18204346 |
| C080580 | O-demethyltramadol | [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol | 18204346 |
| D009853 | Omeprazole | Omeprazole results in decreased activity of CYP2D6 protein | 18420780 |
| D017294 | Ondansetron | CYP2D6 protein affects the metabolism of Ondansetron | 15286053 |
| D017294 | Ondansetron | CYP2D6 protein results in increased metabolism of Ondansetron | 12464242 |
| D008939 | Mitotane | Mitotane results in decreased activity of CYP2D6 protein | 25542188 |
| C015408 | oxatomide | oxatomide results in decreased activity of CYP2D6 protein | 15684493 |
| D010098 | Oxycodone | CYP2D6 gene polymorphism affects the susceptibility to Oxycodone | 20590588 |
| D010098 | Oxycodone | [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone | 20590588 |
| D010098 | Oxycodone | CYP2D6 protein results in decreased methylation of Oxycodone | 19755414 |
| D010098 | Oxycodone | CYP2D6 protein results in increased oxidation of Oxycodone | 20590588 |
| D010100 | Oxygen | CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] | 21566342 |
| D010100 | Oxygen | CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] | 21566342 |
| D010111 | Oxymorphone | CYP2D6 protein results in increased chemical synthesis of Oxymorphone | 19755414 |
| C034364 | ozagrel | CYP2D6 protein results in increased metabolism of ozagrel | 17651725 |
| C034364 | ozagrel | ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 17651725 |
| C034364 | ozagrel | ozagrel results in increased expression of and results in increased activity of CYP2D6 protein | 17651725 |
| D017239 | Paclitaxel | Paclitaxel results in decreased activity of CYP2D6 protein | 19909766 |
| D000068882 | Paliperidone Palmitate | CYP2D6 gene polymorphism affects the abundance of Paliperidone Palmitate | 10639689|1754188 |
| D000068882 | Paliperidone Palmitate | CYP2D6 protein affects the abundance of Paliperidone Palmitate | 10639689|1508980 |
| D010278 | Parathion | CYP2D6 protein affects the metabolism of Parathion | 12669189 |
| D017374 | Paroxetine | CYP2D6 gene mutant form results in decreased metabolism of Paroxetine | 15570195 |
| D017374 | Paroxetine | CYP2D6 gene mutant form results in increased susceptibility to Paroxetine | 15570195 |
| D017374 | Paroxetine | CYP2D6 protein results in increased metabolism of Paroxetine | 14639062 |
| D017374 | Paroxetine | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin] | 11673748 |
| D017374 | Paroxetine | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline] | 11673748 |
| D017374 | Paroxetine | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of 10-hydroxynortriptyline] | 11673748 |
| D017374 | Paroxetine | Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite] | 11673748 |
| D017374 | Paroxetine | Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan] | 19593786 |
| D017374 | Paroxetine | Paroxetine results in decreased activity of CYP2D6 protein | 12173784|1237884 |
| D017374 | Paroxetine | [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased abundance of 4-hydroxy-N-desmethyltamoxifen | 14652237 |
| D017374 | Paroxetine | [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol | 10470702 |
| D017374 | Paroxetine | [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D017374 | Paroxetine | [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol | 10470702 |
| D017374 | Paroxetine | CYP2D6 protein affects the metabolism of Paroxetine | 11673748|8885123 |
| D017374 | Paroxetine | Paroxetine results in decreased activity of CYP2D6 protein | 10470702|1167374 |
| D010419 | Pentamidine | Pentamidine results in decreased activity of CYP2D6 protein | 11124226 |
| C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid inhibits the reaction [CYP2D6 protein results in increased oxidation of bufuralol] | 21964418 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in decreased expression of CYP2D6 mRNA | 17681415 |
| D010480 | Perhexiline | CYP2D6 protein results in decreased susceptibility to Perhexiline | 28762043 |
| D010575 | Pesticides | CYP2D6 gene polymorphism results in increased susceptibility to Pesticides | 14991823 |
| C031181 | phenanthrene | CYP2D6 protein results in increased metabolism of phenanthrene | 9429232 |
| D010622 | Phencyclidine | CYP2D6 protein affects the metabolism of Phencyclidine | 16782764 |
| D010634 | Phenobarbital | Phenobarbital results in decreased activity of CYP2D6 protein | 19909766 |
| C008838 | phenthoate | phenthoate results in decreased activity of CYP2D6 protein | 20183062 |
| D010672 | Phenytoin | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin | 23397584 |
| D010695 | Phlorhizin | Phlorhizin results in increased expression of CYP2D6 mRNA | 22538082 |
| D010936 | Plant Extracts | Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] | 15930738 |
| D010936 | Plant Extracts | Plant Extracts results in decreased activity of CYP2D6 protein | 15900287|1593073 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of CYP2D6 mRNA | 24446304 |
| D010936 | Plant Extracts | Plant Extracts results in increased expression of CYP2D6 mRNA | 15629189 |
| D010936 | Plant Extracts | Plant Extracts results in decreased activity of CYP2D6 protein | 16033948 |
| D011094 | Polyethyleneimine | [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA | 28433809 |
| D011192 | Potassium Dichromate | Potassium Dichromate results in increased expression of CYP2D6 mRNA | 18332044 |
| D011319 | Primaquine | CYP2D6 protein affects the metabolism of Primaquine | 12920490 |
| D011319 | Primaquine | [CYP2D6 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine | 19616568 |
| D011319 | Primaquine | CYP2D6 protein results in increased metabolism of Primaquine | 19616568 |
| D011319 | Primaquine | CYP2D6 protein results in increased susceptibility to Primaquine | 26477383 |
| C045362 | prochloraz | prochloraz results in decreased expression of CYP2D6 mRNA | 20035023 |
| D002727 | Proguanil | Proguanil results in decreased activity of CYP2D6 protein | 11124226 |
| D011398 | Promethazine | CYP2D6 gene polymorphism results in decreased metabolism of Promethazine | 19814645 |
| D011398 | Promethazine | CYP2D6 protein results in increased metabolism of Promethazine | 19814645 |
| D011405 | Propafenone | CYP2D6 protein mutant form affects the susceptibility to Propafenone | 12421483 |
| D011405 | Propafenone | Propafenone results in decreased activity of CYP2D6 protein | 18303146 |
| D011433 | Propranolol | CYP2D6 protein results in increased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | CYP2D6 protein affects the metabolism of Propranolol | 15286053 |
| D011433 | Propranolol | CYP2D6 protein results in increased metabolism of Propranolol | 12464242|2118475 |
| D011433 | Propranolol | CYP2D6 protein results in increased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | CYP2D6 protein results in increased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | Propranolol results in decreased activity of CYP2D6 protein | 20345925 |
| D011715 | Pyrantel | CYP2D6 protein affects the metabolism of Pyrantel | 12920490 |
| D011759 | Pyrrolidines | CYP2D6 protein affects the metabolism of Pyrrolidines | 21053377 |
| D011794 | Quercetin | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D011794 | Quercetin | Quercetin results in decreased activity of CYP2D6 protein | 18420780 |
| D000069348 | Quetiapine Fumarate | CYP2D6 protein affects the metabolism of Quetiapine Fumarate | 17632227 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased oxidation of Propranolol | 19853591 |
| D011802 | Quinidine | CYP2D6 protein results in increased metabolism of Quinidine | 17702393 |
| D011802 | Quinidine | Quinidine binds to and results in decreased activity of CYP2D6 protein | 28887089 |
| D011802 | Quinidine | "Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]" | 20345925 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine] | 18238857 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol] | 11377097 |
| D011802 | Quinidine | Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins] | 23850985 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol] | 12569440 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 16595712|2385098 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod] | 11560869 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] | 19230594 |
| D011802 | Quinidine | Quinidine results in decreased activity of CYP2D6 gene mutant form | 11673748 |
| D011802 | Quinidine | Quinidine results in decreased activity of CYP2D6 protein | 12464242|1246791 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone | 20590588 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen | 14652237 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite | 21277363 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen | 14652237 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased oxidation of Propranolol | 19853591 |
| D011802 | Quinidine | Quinidine results in decreased activity of CYP2D6 protein | 18420780 |
| D011802 | Quinidine | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride | 20669986 |
| D011802 | Quinidine | Quinidine affects the activity of CYP2D6 protein | 18292293 |
| D011802 | Quinidine | Quinidine results in decreased activity of CYP2D6 | 19053182 |
| D011802 | Quinidine | Quinidine results in decreased activity of CYP2D6 protein | 10828259|1985359 |
| D011803 | Quinine | Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] | 14979094 |
| C523099 | rabeprazole-thioether | rabeprazole-thioether inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] | 15258107 |
| C005709 | raubasine | raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] | 15930738 |
| C005709 | raubasine | raubasine results in decreased activity of CYP2D6 protein | 15930738 |
| C059514 | resveratrol | resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] | 20716633 |
| C059514 | resveratrol | resveratrol results in decreased activity of CYP2D6 protein | 18420780 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP2D6 mRNA | 19041851 |
| D018967 | Risperidone | CYP2D6 gene polymorphism affects the abundance of Risperidone | 17541883|1870899 |
| D018967 | Risperidone | CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone | 10639689 |
| D018967 | Risperidone | CYP2D6 gene polymorphism affects the metabolism of Risperidone | 18708991|1938799 |
| D018967 | Risperidone | CYP2D6 gene polymorphism affects the susceptibility to Risperidone | 23609392 |
| D018967 | Risperidone | CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone | 15565299 |
| D018967 | Risperidone | CYP2D6 gene polymorphism results in decreased metabolism of Risperidone | 17541883 |
| D018967 | Risperidone | CYP2D6 protein affects the abundance of Risperidone | 15089809|1754188 |
| D018967 | Risperidone | CYP2D6 protein affects the metabolism of and affects the abundance of Risperidone | 10639689|1526090 |
| D018967 | Risperidone | CYP2D6 protein affects the metabolism of Risperidone | 15669884 |
| D018967 | Risperidone | CYP2D6 protein polymorphism affects the susceptibility to Risperidone | 15669884 |
| D018967 | Risperidone | CYP2D6 protein results in increased metabolism of Risperidone | 16044105|1722471 |
| D018967 | Risperidone | CYP2D6 protein results in increased susceptibility to Risperidone | 23609392 |
| D018967 | Risperidone | CYP2D6 protein results in increased metabolism of Risperidone | 12775973 |
| D019438 | Ritonavir | CYP2D6 protein affects the metabolism of Ritonavir | 15286053 |
| C039685 | Ro 03-7410 | CYP2D6 protein results in increased chemical synthesis of Ro 03-7410 | 12401345 |
| C039685 | Ro 03-7410 | [CYP2D6 protein results in increased metabolism of bufuralol] which results in increased chemical synthesis of Ro 03-7410 | 25084468 |
| C089730 | rosiglitazone | rosiglitazone results in decreased activity of CYP2D6 protein | 12642470 |
| C055163 | sabeluzole | CYP2D6 protein results in increased metabolism of sabeluzole | 11259989 |
| D012451 | Safrole | CYP2D6 protein results in increased metabolism of Safrole | 20507880 |
| D012451 | Safrole | [CYP2D6 protein results in increased metabolism of Safrole] which results in increased abundance of 1'-hydroxysafrole | 20507880 |
| D012451 | Safrole | Safrole results in decreased activity of CYP2D6 protein | 15778010 |
| C010327 | salinomycin | salinomycin results in decreased activity of CYP2D6 protein | 26282489 |
| C515233 | saracatinib | CYP2D6 protein results in increased oxidation of saracatinib | 27769111 |
| C064294 | sarpogrelate | sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] | 24167220 |
| C064294 | sarpogrelate | sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] | 24167220 |
| C064294 | sarpogrelate | sarpogrelate metabolite results in decreased activity of CYP2D6 protein | 24167220 |
| C064294 | sarpogrelate | sarpogrelate results in decreased activity of CYP2D6 protein | 24167220 |
| C009238 | senkirkine | senkirkine results in decreased expression of CYP2D6 mRNA | 26100227 |
| C009244 | serpentine (alkaloid) | serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] | 15930738 |
| C009244 | serpentine (alkaloid) | serpentine (alkaloid) results in decreased activity of CYP2D6 protein | 15930738 |
| D020280 | Sertraline | CYP2D6 protein results in decreased methylation of and results in increased metabolism of Sertraline | 15547048 |
| D020280 | Sertraline | CYP2D6 protein affects the metabolism of Sertraline | 8885123 |
| C016101 | shikonin | shikonin results in decreased activity of CYP2D6 protein | 28941798 |
| C058254 | sibutramine | sibutramine results in decreased activity of CYP2D6 protein | 23777987 |
| D019821 | Simvastatin | CYP2D6 polymorphism affects the susceptibility to Simvastatin | 11753271 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of CYP2D6 protein | 11368792 |
| D013034 | Sparteine | CYP2D6 protein results in increased metabolism of Sparteine | 11907490 |
| D013034 | Sparteine | CYP2D6 protein affects the metabolism of Sparteine | 11673748 |
| C053003 | S-phenyl-N-acetylcysteine | CYP2D6 affects the abundance of S-phenyl-N-acetylcysteine | 10780264 |
| C024075 | styrofoam | styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] | 19909766 |
| C024075 | styrofoam | styrofoam analog results in decreased activity of CYP2D6 protein | 19909766 |
| D013629 | Tamoxifen | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen | 23397584 |
| D013629 | Tamoxifen | CYP2D6 gene affects the abundance of and affects the susceptibility to Tamoxifen | 20124171 |
| D013629 | Tamoxifen | CYP2D6 gene polymorphism affects the susceptibility to Tamoxifen | 19189210|1918921 |
| D013629 | Tamoxifen | CYP2D6 gene polymorphism results in decreased susceptibility to Tamoxifen | 20309015 |
| D013629 | Tamoxifen | CYP2D6 gene polymorphism results in increased susceptibility to Tamoxifen | 21152245 |
| D013629 | Tamoxifen | CYP2D6 protein affects the metabolism of Tamoxifen | 15632378|1596125 |
| D013629 | Tamoxifen | CYP2D6 protein results in increased metabolism of Tamoxifen | 20123649 |
| D013629 | Tamoxifen | "[CYP2D6 protein results in increased metabolism of Tamoxifen] which results in decreased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| D013629 | Tamoxifen | "[CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| D013629 | Tamoxifen | [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen | 29285606 |
| D013629 | Tamoxifen | [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of Tamoxifen metabolite | 29285606 |
| D013629 | Tamoxifen | [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of 4-hydroxy-N-desmethyltamoxifen | 29285606 |
| D013629 | Tamoxifen | [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of N-desmethyltamoxifen | 29285606 |
| D013629 | Tamoxifen | CYP2D6 protein results in increased susceptibility to Tamoxifen | 19244106 |
| D013629 | Tamoxifen | Tamoxifen results in increased expression of CYP2D6 protein | 19812351 |
| D013629 | Tamoxifen | Tamoxifen results in decreased activity of CYP2D6 protein | 18420780 |
| D013629 | Tamoxifen | CYP2D6 protein results in increased hydroxylation of Tamoxifen | 26530625 |
| D013629 | Tamoxifen | [CYP2D6 protein results in increased hydroxylation of Tamoxifen] which results in increased abundance of afimoxifene | 26530625 |
| C105050 | tegaserod | CYP2D6 protein results in increased metabolism of tegaserod | 11560869 |
| C105050 | tegaserod | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod] | 11560869 |
| C105050 | tegaserod | tegaserod results in decreased activity of CYP2D6 protein | 11560869 |
| C106791 | telithromycin | telithromycin results in decreased activity of CYP2D6 protein | 19755414 |
| C041359 | terbinafine | terbinafine results in decreased activity of CYP2D6 protein | 24894748 |
| C041359 | terbinafine | [terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] | 24894748 |
| D008063 | Thioctic Acid | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D013881 | Thioridazine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine | 23397584 |
| D013881 | Thioridazine | CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine | 19482014 |
| D013988 | Ticlopidine | CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite | 19170597 |
| D013988 | Ticlopidine | Ticlopidine results in decreased activity of CYP2D6 protein | 10759690 |
| D013999 | Timolol | CYP2D6 gene SNP affects the susceptibility to Timolol | 19284319|2092557 |
| D013999 | Timolol | Timolol results in decreased activity of CYP2D6 protein | 20345925 |
| D000068737 | Tolterodine Tartrate | CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate | 28087463 |
| D000068737 | Tolterodine Tartrate | CYP2D6 protein results in increased metabolism of Tolterodine Tartrate | 10583026 |
| D000068737 | Tolterodine Tartrate | Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] | 10583026 |
| D014147 | Tramadol | CYP2D6 gene mutant form affects the metabolism of Tramadol | 12191703 |
| D014147 | Tramadol | CYP2D6 gene mutant form results in increased metabolism of Tramadol | 18204346 |
| D014147 | Tramadol | CYP2D6 gene mutant form results in increased susceptibility to Tramadol | 18204346 |
| D014147 | Tramadol | CYP2D6 gene polymorphism affects the metabolism of Tramadol | 17570739|1852059 |
| D014147 | Tramadol | CYP2D6 gene polymorphism affects the susceptibility to Tramadol | 16497087 |
| D014147 | Tramadol | CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol | 16960721 |
| D014147 | Tramadol | CYP2D6 protein affects the susceptibility to Tramadol | 16960721 |
| D014147 | Tramadol | CYP2D6 protein results in decreased methylation of Tramadol | 14624403|1736112 |
| D014147 | Tramadol | CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol | 18204346 |
| D014147 | Tramadol | [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol | 18204346 |
| D014147 | Tramadol | CYP2D6 protein results in increased metabolism of Tramadol | 18520597|1871390 |
| D014147 | Tramadol | CYP2D6 protein affects the methylation of Tramadol | 12893130 |
| C507866 | trans-1,2-dihydro-1,2-naphthalenediol | "CYP2D6 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediol" | 16243959 |
| D014191 | Tranylcypromine | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D014212 | Tretinoin | Tretinoin results in decreased activity of CYP2D6 protein | 18420780 |
| D022882 | Trihalomethanes | CYP2D6 protein results in increased metabolism of Trihalomethanes | 24647036 |
| C057693 | troglitazone | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone | 23397584 |
| D014363 | Tryptamines | Tryptamines analog results in decreased activity of CYP2D6 protein | 26599973 |
| D014363 | Tryptamines | [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan | 26599973 |
| D014439 | Tyramine | CYP2D6 protein results in increased metabolism of Tyramine | 26763401 |
| D014439 | Tyramine | [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine | 26763401 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of CYP2D6 gene | 29154799 |
| C521013 | veliparib | CYP2D6 protein results in increased metabolism of veliparib | 21436403 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride | 10774634|1821445 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride | 16958828 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride | 10877013|1093388 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride | 17803873 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride | 10877013|1093388 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride | 10774634|1604410 |
| D000069470 | Venlafaxine Hydrochloride | Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein | 15632378 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 protein affects the metabolism of Venlafaxine Hydrochloride | 8885123 |
| D000069470 | Venlafaxine Hydrochloride | CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride | 18303146|2184014 |
| D000069470 | Venlafaxine Hydrochloride | [CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of Desvenlafaxine Succinate | 21840145 |
| D000069470 | Venlafaxine Hydrochloride | "[[CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of Desvenlafaxine Succinate] which results in increased abundance of N,O-didesmethylvenlafaxine" | 21840145 |
| D014700 | Verapamil | Verapamil results in decreased activity of CYP2D6 protein | 18420780 |
| D002762 | Cholecalciferol | Cholecalciferol results in decreased activity of CYP2D6 protein | 18420780 |
| D014859 | Warfarin | Warfarin results in decreased activity of CYP2D6 protein | 18420780 |
| C530155 | YM 758 | CYP2D6 protein results in increased metabolism of YM 758 | 19230594 |
| C530155 | YM 758 | Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] | 19230594 |
| C530155 | YM 758 | Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] | 19230594 |
| C530155 | YM 758 | YM 758 inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] | 19230594 |
| D015016 | Yohimbine | CYP2D6 gene polymorphism affects the metabolism of Yohimbine | 15289791 |
| D015032 | Zinc | Zinc deficiency results in increased expression of CYP2D6 mRNA | 18356318 |
| C049109 | zolpidem | CYP2D6 protein results in increased metabolism of zolpidem | 16449812 |