Gene: GRK3

157
ADRBK2|BARK2
G protein-coupled receptor kinase 3
protein-coding
22q12.1
Ensembl:ENSG00000100077 MIM:109636 Vega:OTTHUMG00000150280 UniprotKB:P35626
NC_000022.11
PubMed
0   ANCO-SNPs
OD|CD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.421e-1 (AD)  1.616e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of GRK3 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRK3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRK3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRK3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRK3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRK3 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GRK3 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRK3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GRK3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRK3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRK3 mRNA16483693
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of GRK3 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of GRK3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRK3 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRK3 mRNA19770486|2222880
C006780bisphenol Abisphenol A results in decreased expression of GRK3 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of GRK3 gene22576693
C006780bisphenol Abisphenol A results in decreased methylation of GRK3 promoter27312807
C018475butyraldehydebutyraldehyde results in decreased expression of GRK3 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of GRK3 promoter22457795
D002713ChlorineChlorine results in increased expression of GRK3 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of GRK3 mRNA18636392
D004390ChlorpyrifosChlorpyrifos affects the expression of GRK3 mRNA18812211
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRK3 mRNA17452286
D019327Copper SulfateCopper Sulfate results in increased expression of GRK3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GRK3 mRNA25562108
D003891DesipramineDesipramine affects the localization of GRK3 protein12527474
D003976DiazinonDiazinon results in increased expression of GRK3 mRNA17452286
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GRK3 mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of GRK3 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GRK3 mRNA24535843
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GRK3 mRNA22079256
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of GRK3 promoter27415467
D004397FonofosFonofos results in increased methylation of GRK3 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of GRK3 mRNA23649840
D019833GenisteinGenistein results in increased expression of GRK3 mRNA24967385
D017313FenretinideFenretinide results in increased expression of GRK3 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of GRK3 mRNA17183730
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRK3 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of GRK3 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRK3 mRNA25613284
D048628KetolidesKetolides analog results in increased expression of GRK3 mRNA24967691
C008261lead acetatelead acetate results in increased expression of GRK3 mRNA21829687
D016210Methacholine ChlorideGRK3 mutant form affects the susceptibility to Methacholine Chloride10198406
D008713MethimazoleMethimazole results in increased expression of GRK3 mRNA22504374
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRK3 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of GRK3 mRNA12710931
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GRK3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GRK3 mRNA"25554681
D009599NitroprussideGRK3 mutant form affects the susceptibility to Nitroprusside10198406
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of GRK3 mRNA18636392
D010278ParathionParathion results in increased methylation of GRK3 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRK3 mRNA"25510870
D010578PetroleumPetroleum affects the expression of GRK3 mRNA25208076
D010634PhenobarbitalPhenobarbital results in decreased expression of GRK3 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of GRK3 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of GRK3 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GRK3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GRK3 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GRK3 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRK3 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of GRK3 mRNA22504374
D053260SootSoot results in decreased expression of GRK3 mRNA26551751
C012568terbufosterbufos results in increased methylation of GRK3 promoter22847954
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRK3 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRK3 protein18951874
D013806TheophyllineTheophylline results in decreased expression of GRK3 mRNA18951874
D013849ThimerosalThimerosal results in decreased expression of GRK3 mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of GRK3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GRK3 mRNA18087596
D014212TretinoinTretinoin results in increased expression of GRK3 mRNA23724009
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of GRK3 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRK3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GRK3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRK3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of GRK3 mRNA26272509
C029297vinylidene chloridevinylidene chloride results in decreased expression of GRK3 mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of GRK3 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of GRK3 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of GRK3 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS8427589  
GO:0004703G-protein coupled receptor kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0047696beta-adrenergic receptor kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0007165signal transduction-TAS8427589  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0031623receptor internalization-IDA20074556  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04740Olfactory transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24629717Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5. (2014 Nov 15)Gluck LBiol Psychiatry
17621168Association analysis of GRK3 gene promoter variants in cocaine abuse. (2007 Aug)Guindalini CPsychiatr Genet