Gene: CYP2J2

1573
CPJ2|CYPIIJ2
cytochrome P450 family 2 subfamily J member 2
protein-coding
1p32.1
Ensembl:ENSG00000134716 MIM:601258 Vega:OTTHUMG00000008991 UniprotKB:P51589
NG_007931.1
PubMed
0   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.025e-1 (AD)  8.229e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDR10.847
KLF150.843
NFIA0.841
PLXNB10.841
NPAS30.837
FGFR20.833
IQCK0.83
ZHX20.828
FBXL70.827
EGLN30.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH5-0.516
PRSS12-0.513
MCHR1-0.511
RTP1-0.492
HS6ST3-0.488
CCDC68-0.487
TNFRSF11A-0.484
CDH7-0.483
ARHGAP20-0.48
KCNH1-0.479

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00169CholecalciferolSmall Molecule67-97-0Approved|NutraceuticalEnzyme
DB00179MasoprocolSmall Molecule27686-84-6Approved|InvestigationalEnzyme
DB00342TerfenadineSmall Molecule50679-08-8Approved|WithdrawnEnzyme
DB00637AstemizoleSmall Molecule68844-77-9Approved|WithdrawnEnzyme
DB04725LicofeloneSmall Molecule156897-06-2InvestigationalEnzyme
DB06228RivaroxabanSmall Molecule366789-02-8ApprovedEnzyme
DB06605ApixabanSmall Molecule503612-47-3ApprovedEnzyme
DB08918LevomilnacipranSmall Molecule96847-54-0Approved|InvestigationalEnzyme
DB08931RiociguatSmall Molecule625115-55-1ApprovedEnzyme
DB09148Florbetaben (18F)Small Molecule902143-01-5ApprovedEnzyme
ID Drug Name Action PubMed
C0917651,4-dihydroxy-2-nonene"[CYP2J2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene"21766881
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYP2J2 mRNA"23962555
C5865422'-(glutathion-S-yl)-deschlorodiclofenac[CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac24246759
C0275764-hydroxy-2-nonenal[CYP2J2 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid21766881
C0275764-hydroxy-2-nonenal"[CYP2J2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene"21766881
C0275764-hydroxy-2-nonenalCYP2J2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal21766881
C0917664-hydroxy-2-nonenoic acid[CYP2J2 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid21766881
C5444715-hydroxythalidomideCYP2J2 protein results in increased metabolism of 5-hydroxythalidomide24350712
D000082AcetaminophenAcetaminophen results in decreased expression of CYP2J2 mRNA29067470
D000447AldehydesAldehydes results in increased expression of CYP2J2 mRNA25014914
C011512alpha-naphthoflavonealpha-naphthoflavone results in decreased activity of CYP2J2 protein12851038
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CYP2J2 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of CYP2J2 mRNA19774075
D016718Arachidonic AcidArachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]12386130
C006632arsenic trioxideCYP2J2 protein results in decreased susceptibility to arsenic trioxide20707922
D016589AstemizoleArachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]12386130
D016589AstemizoleCYP2J2 protein results in decreased methylation of Astemizole12386130|1586103
D016589AstemizoleCYP2J2 protein results in increased metabolism of Astemizole17162467
D016589Astemizoleebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]12386130
D001280AtrazineAtrazine results in increased expression of CYP2J2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP2J2 mRNA20106945|2231617
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP2J2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of CYP2J2 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of CYP2J2 mRNA25181051
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of CYP2J2 mRNA24021950
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of CYP2J2 mRNA24021950
C018475butyraldehydebutyraldehyde results in increased expression of CYP2J2 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYP2J2 mRNA15963578
D002927CimetidineCimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]11856816
D003024ClozapineCYP2J2 protein results in increased metabolism of Clozapine18809730
D003042CocaineCimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]11856816
D003042CocaineCocaine results in increased expression of CYP2J2 protein11856816
D003042CocaineMetyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]11856816
D019327Copper SulfateCopper Sulfate results in decreased expression of CYP2J2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CYP2J2 mRNA20106945|2556210
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CYP2J2 mRNA28412506
D004317DoxorubicinCYP2J2 protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]19429816
D004317DoxorubicinCYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of ANKRD1 protein]19429816
D004317DoxorubicinCYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of CAT protein]19429816
D004317DoxorubicinCYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of MYH7 protein]19429816
D004317DoxorubicinCYP2J2 protein results in increased metabolism of and results in decreased susceptibility to Doxorubicin19429816
D004317DoxorubicinDoxorubicin results in decreased expression of CYP2J2 protein19429816
C058249ebastineCYP2J2 protein results in increased hydroxylation of ebastine12386130|1586103
C058249ebastineebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]12386130
C058249ebastineebastine results in decreased activity of CYP2J2 protein12851038
D005978Glutathione[CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac24246759
C071834glycidamideglycidamide results in decreased expression of CYP2J2 mRNA17822822
D007654KetoconazoleKetoconazole results in decreased activity of CYP2J2 protein12851038
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CYP2J2 mRNA"24972896
D008797MetyraponeMetyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]11856816
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of CYP2J2 mRNA22108045
C523799MRK 003MRK 003 results in decreased expression of CYP2J2 mRNA21169257
C058272norclozapineCYP2J2 protein results in increased chemical synthesis of norclozapine18809730
C046012pentanalpentanal results in increased expression of CYP2J2 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYP2J2 mRNA19162173
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYP2J2 mRNA alternative form18501439
D010578PetroleumPetroleum affects the expression of CYP2J2 mRNA25208076
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP2J2 mRNA19710929
C467566pomalidomideCYP2J2 protein results in increased oxidation of pomalidomide24350712
C045362prochlorazprochloraz results in decreased expression of CYP2J2 mRNA20035023
C005556propionaldehydepropionaldehyde results in increased expression of CYP2J2 mRNA26079696
C030984pyrenepyrene results in decreased expression of CYP2J2 mRNA15963578
D011794QuercetinQuercetin results in increased expression of CYP2J2 mRNA21632981
D011794QuercetinQuercetin results in decreased expression of CYP2J2 mRNA16455785
C089730rosiglitazonerosiglitazone results in increased expression of CYP2J2 mRNA24021950
C017947sodium arsenitesodium arsenite results in increased expression of CYP2J2 mRNA21281968
D016593TerfenadineCYP2J2 protein results in increased hydroxylation of Terfenadine24021950
D016593TerfenadineTerfenadine analog results in decreased activity of CYP2J2 protein19289568
D016593TerfenadineTerfenadine results in decreased activity of CYP2J2 protein12851038
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP2J2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP2J2 mRNA19619570|2163298
D014191TranylcypromineTranylcypromine results in decreased activity of CYP2J2 protein12851038
D014212TretinoinTretinoin results in decreased expression of CYP2J2 mRNA16985168|2372400
C057693troglitazonetroglitazone results in decreased activity of CYP2J2 protein12851038
D014520UrethaneUrethane results in increased expression of CYP2J2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of CYP2J2 mRNA28001369|2915479
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of CYP2J2 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0008392arachidonic acid epoxygenase activity-IDA11901223  
GO:0008392arachidonic acid epoxygenase activity-TAS-  
GO:0008395steroid hydroxylase activity-IBA21873635  
GO:0008404arachidonic acid 14,15-epoxygenase activity-IDA11901223  
GO:0008405arachidonic acid 11,12-epoxygenase activity-IDA11901223  
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0070330aromatase activity-IEA-  
GO:0071614linoleic acid epoxygenase activity-IDA11901223  
GO ID GO Term Qualifier Evidence PubMed
GO:0006082organic acid metabolic process-IBA21873635  
GO:0006690icosanoid metabolic process-TAS8631948  
GO:0006805xenobiotic metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-TAS11901223  
GO:0008016regulation of heart contraction-TAS8631948  
GO:0019373epoxygenase P450 pathway-IDA11901223  
GO:0019373epoxygenase P450 pathway-TAS-  
GO:0042738exogenous drug catabolic process-IBA21873635  
GO:0043651linoleic acid metabolic process-IDA11901223  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa00591Linoleic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211935Fatty acidsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211981XenobioticsTAS
R-HSA-2142670Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25872594Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. (2015 May)Toselli FAlcohol Clin Exp Res
23565323Genotype and age at Parkinson disease diagnosis. (2013)Searles Nielsen SInt J Mol Epidemiol Genet
17429317CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. (2007 May)Lee CRPharmacogenet Genomics
22232929[Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors]. (2011 Oct)Akhmadishina LAGenetika
28272236Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population. (2017 Mar)Wang SYMedicine (Baltimore)
18216721Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population. (2008 Jan)Zhang LPharmacogenet Genomics
26095139Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)Toselli FXenobiotica
17126841Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction. (2007 Nov)Liu PYAtherosclerosis