| C065719 | 10-hydroxywarfarin | [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 20735727 |
| C065719 | 10-hydroxywarfarin | CYP3A4 protein affects the chemical synthesis of 10-hydroxywarfarin | 16035367 |
| C065719 | 10-hydroxywarfarin | CYP3A4 protein results in increased chemical synthesis of 10-hydroxywarfarin | 20429590 |
| C046783 | 11,12-epoxy-5,8,14-eicosatrienoic acid | "CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid" | 12675279 |
| C046783 | 11,12-epoxy-5,8,14-eicosatrienoic acid | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]" | 12675279 |
| C495657 | 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane | "CYP3A4 protein results in increased hydroxylation of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane" | 12167570|9047321 |
| C030387 | 1,2,3,5-tetrachlorobenzene | "CYP3A4 protein results in increased oxidation of 1,2,3,5-tetrachlorobenzene" | 7747284 |
| C046127 | 1,25-dihydroxy-26,27-dimethylcholecalciferol | "[1,25-dihydroxy-26,27-dimethylcholecalciferol binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA" | 20153625 |
| C015153 | 1,2-dilauroylphosphatidylcholine | "[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein" | 1627548 |
| C517214 | 12-hydroxyellipticine | [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine] | 22390216 |
| C517214 | 12-hydroxyellipticine | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine | 22390216 |
| C517214 | 12-hydroxyellipticine | CYP3A4 protein results in increased chemical synthesis of 12-hydroxyellipticine | 22917556 |
| C439392 | 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline | "CYP3A4 protein results in increased oxidation of 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline" | 15585365 |
| C017251 | 1,2-oleoylphosphatidylcholine | "[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein" | 1627548 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | [NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C585955 | 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| C053854 | 1,3,8-trihydroxy-6-hydroxymethylanthraquinone | "CYP3A4 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone" | 27989148 |
| C015068 | 1-(3-chlorophenyl)piperazine | 1-(3-chlorophenyl)piperazine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21402137 |
| C015068 | 1-(3-chlorophenyl)piperazine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [1-(3-chlorophenyl)piperazine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| C031338 | 13-cis-retinal | 13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| C031338 | 13-cis-retinal | 13-cis-retinal results in increased activity of CYP3A4 protein | 16632523 |
| C517215 | 13-hydroxyellipticine | [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] | 22390216 |
| C517215 | 13-hydroxyellipticine | CYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] | 22390216 |
| C517215 | 13-hydroxyellipticine | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine | 22390216 |
| C517215 | 13-hydroxyellipticine | CYP3A4 protein results in increased chemical synthesis of 13-hydroxyellipticine | 22917556 |
| C046782 | 14,15-epoxy-5,8,11-eicosatrienoic acid | "CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid" | 12675279 |
| C046782 | 14,15-epoxy-5,8,11-eicosatrienoic acid | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]" | 12675279 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP3A4 gene]" | 15764585 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "9-cis-retinal promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[9-cis-retinal co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[alitretinoin co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[Isotretinoin co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "9-cis-retinal promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "alitretinoin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "Isotretinoin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C038806 | 1,4-dihydropyridine | "CYP3A4 protein results in increased oxidation of 1,4-dihydropyridine" | 10805063 |
| C091765 | 1,4-dihydroxy-2-nonene | "[[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene" | 21766881 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene results in increased activity of CYP3A4 protein" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "CYP3A4 protein results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP3A4 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP3A4 protein results in increased metabolism of N,N-didesmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C090768 | 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | "[CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C035342 | 1,4-naphthoquinone | "1,4-naphthoquinone results in increased expression of CYP3A4 mRNA" | 18602459 |
| C035342 | 1,4-naphthoquinone | "CYP3A4 protein results in increased abundance of 1,4-naphthoquinone" | 16243959 |
| C106746 | 1,5-benzothiazepine | "1,5-benzothiazepine analog results in increased expression of CYP3A4 mRNA" | 21315811 |
| C558737 | 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea | "1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea affects the activity of CYP3A4 protein" | 21341682 |
| C033309 | 1,6-dinitropyrene | "CYP3A4 protein affects the metabolism of 1,6-dinitropyrene" | 2180560 |
| C486136 | 16-O-demethylaconitine | [CYP3A4 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| C020365 | 17-alpha-hydroxy-progesterone caproate | CYP3A4 protein affects the metabolism of 17-alpha-hydroxy-progesterone caproate | 20097724 |
| C492368 | 1-(alpha,apha-dimethylbenzyl)-3-(4-methylphenyl)urea | "1-(alpha,apha-dimethylbenzyl)-3-(4-methylphenyl)urea results in increased expression of CYP3A4 mRNA" | 17293382 |
| C042533 | 1 alpha-hydroxyergocalciferol | CYP3A4 protein results in increased hydroxylation of 1 alpha-hydroxyergocalciferol | 15005856 |
| C478004 | 1-hydroxy-2,3,5-trimethoxyxanthone | "CYP3A4 protein results in increased metabolism of 1-hydroxy-2,3,5-trimethoxyxanthone" | 24380714 |
| C040081 | 1-hydroxymethylmidazolam | acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C040081 | 1-hydroxymethylmidazolam | Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C040081 | 1-hydroxymethylmidazolam | CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342 |
| C040081 | 1-hydroxymethylmidazolam | CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam | 12695342 |
| C040081 | 1-hydroxymethylmidazolam | CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam | 12401345|1269534 |
| C040081 | 1-hydroxymethylmidazolam | CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam | 27485346 |
| C040081 | 1-hydroxymethylmidazolam | [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide | 27485346 |
| C040081 | 1-hydroxymethylmidazolam | [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam | 27485346 |
| C040081 | 1-hydroxymethylmidazolam | [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam | 21053930 |
| C040081 | 1-hydroxymethylmidazolam | diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 18191104 |
| C040081 | 1-hydroxymethylmidazolam | flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C040081 | 1-hydroxymethylmidazolam | flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C040081 | 1-hydroxymethylmidazolam | galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C040081 | 1-hydroxymethylmidazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam] | 12695342 |
| C040081 | 1-hydroxymethylmidazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342|2023384 |
| C040081 | 1-hydroxymethylmidazolam | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam | 10997946 |
| C040081 | 1-hydroxymethylmidazolam | [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam | 10997946 |
| C040081 | 1-hydroxymethylmidazolam | Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 18191104 |
| C040081 | 1-hydroxymethylmidazolam | Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342 |
| C040081 | 1-hydroxymethylmidazolam | Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 20233841 |
| C040081 | 1-hydroxymethylmidazolam | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342 |
| C061795 | 1-hydroxymethylmidazolam glucuronide | [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide | 27485346 |
| C033146 | 1-hydroxypyrene | CYP3A4 protein affects the chemical synthesis of 1-hydroxypyrene | 15910734 |
| C033146 | 1-hydroxypyrene | Testosterone affects the reaction [CYP3A4 protein affects the chemical synthesis of 1-hydroxypyrene] | 15910734 |
| C029350 | 1-naphthol | CYP3A4 protein results in increased abundance of 1-naphthol | 16243959 |
| C024336 | 1-phenylazo-2-naphthol | CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol] | 17159775|1935888 |
| C024336 | 1-phenylazo-2-naphthol | CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol | 17159775|1935888 |
| C463480 | 1-pyrenebutanol | 1-pyrenebutanol binds to CYP3A4 protein | 17198380 |
| C463480 | 1-pyrenebutanol | Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol] | 18206979 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | "2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in decreased activity of CYP3A4 protein" | 25542188 |
| C054917 | 2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid | "2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid results in decreased activity of CYP3A4 protein" | 25542188 |
| C511295 | 2,2',4,4'-tetrabromodiphenyl ether | "[2,2',4,4'-tetrabromodiphenyl ether results in increased activity of CYP3A4 protein] which results in increased expression of CYP2B6 mRNA" | 24218150 |
| C511295 | 2,2',4,4'-tetrabromodiphenyl ether | "2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP3A4 mRNA" | 24218150 |
| C029141 | 2,2,5,7,8-pentamethyl-1-hydroxychroman | "2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of CYP3A4 mRNA" | 19135037 |
| C120227 | 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide | "2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased expression of CYP3A4 mRNA" | 24819614 |
| C568513 | 2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester | "2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester affects the activity of CYP3A4 protein" | 21838328 |
| C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | "2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CYP3A4 mRNA" | 22664347 |
| C044563 | 24-hydroxycholesterol | [24-hydroxycholesterol co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA | 23732298 |
| C562251 | 24-norcholan-2,3,24-tryl-2,3,23-sulfuric acid | "24-norcholan-2,3,24-tryl-2,3,23-sulfuric acid results in increased expression of CYP3A4 mRNA" | 21141967 |
| C009407 | 2,5,2',5'-tetrachlorobiphenyl | "[POR protein co-treated with CYP3A4 protein] affects the susceptibility to 2,5,2',5'-tetrachlorobiphenyl" | 27913846 |
| C023514 | 2,6-dinitrotoluene | "2,6-dinitrotoluene results in increased expression of CYP3A4 mRNA" | 20406850 |
| C014953 | 2-acetyltributylcitrate | 2-acetyltributylcitrate promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 21742782 |
| C014953 | 2-acetyltributylcitrate | 2-acetyltributylcitrate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21742782 |
| C014953 | 2-acetyltributylcitrate | 2-acetyltributylcitrate results in increased activity of CYP3A4 protein | 21742782 |
| C014953 | 2-acetyltributylcitrate | 2-acetyltributylcitrate results in increased expression of CYP3A4 mRNA | 21742782 |
| C014953 | 2-acetyltributylcitrate | Calcitriol promotes the reaction [2-acetyltributylcitrate results in increased activity of CYP3A4 protein] | 21742782 |
| C014953 | 2-acetyltributylcitrate | Calcitriol promotes the reaction [2-acetyltributylcitrate results in increased expression of CYP3A4 mRNA] | 21742782 |
| C014953 | 2-acetyltributylcitrate | NR1I2 protein affects the reaction [2-acetyltributylcitrate results in increased expression of CYP3A4 mRNA] | 21742782 |
| C049584 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | "CYP3A4 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine" | 1913651 |
| C036989 | 2-amino-3,4-dimethylimidazo(4,5-f)quinoline | "CYP3A4 affects the activity of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline" | 8844805 |
| C036989 | 2-amino-3,4-dimethylimidazo(4,5-f)quinoline | "[CYP3A4 co-treated with Rifampin] affects the activity of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline" | 8844805 |
| C012180 | 2-aminopyrimidine | 2-aminopyrimidine analog results in decreased activity of CYP3A4 protein | 19317514 |
| C003898 | 2-anisidine | CYP3A4 protein results in increased oxidation of 2-anisidine | 15828049 |
| C093872 | 2-chloro-N-(2,6-diethylphenyl)acetamide | "CYP3A4 protein results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide" | 18273908 |
| C093872 | 2-chloro-N-(2,6-diethylphenyl)acetamide | "CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2,6-diethylphenyl)acetamide" | 10475613 |
| C093872 | 2-chloro-N-(2,6-diethylphenyl)acetamide | "[CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide" | 18273908 |
| C093872 | 2-chloro-N-(2,6-diethylphenyl)acetamide | "CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2,6-diethylphenyl)acetamide" | 17207564 |
| C576261 | 2-ethylhexyl 2,3,4,5-tetrabromobenzoate | "2-ethylhexyl 2,3,4,5-tetrabromobenzoate metabolite results in increased expression of CYP3A4 mRNA" | 27506419 |
| C576261 | 2-ethylhexyl 2,3,4,5-tetrabromobenzoate | "2-ethylhexyl 2,3,4,5-tetrabromobenzoate results in increased expression of CYP3A4 mRNA" | 27506419 |
| C586542 | 2'-(glutathion-S-yl)-deschlorodiclofenac | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac | 24246759 |
| C586542 | 2'-(glutathion-S-yl)-deschlorodiclofenac | Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac] | 24246759 |
| C053054 | 2-hydroxyemodin | CYP3A4 protein results in increased chemical synthesis of 2-hydroxyemodin | 27989148 |
| C001390 | 2-hydroxyestradiol | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| C001390 | 2-hydroxyestradiol | CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol | 16790556 |
| C001390 | 2-hydroxyestradiol | decamethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| C001390 | 2-hydroxyestradiol | Fonofos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| C001390 | 2-hydroxyestradiol | Permethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| C028405 | 2-naphthol | CYP3A4 protein results in increased abundance of 2-naphthol | 16243959 |
| C540904 | 2-oxo-clopidogrel | CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel | 19812348 |
| C540904 | 2-oxo-clopidogrel | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel] | 19812348 |
| C109602 | 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate | "3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate results in decreased activity of CYP3A4 protein" | 16049129 |
| C109602 | 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate | "CYP3A4 protein affects the metabolism of 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate" | 16049129 |
| C532666 | 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione | "CYP3A4 protein results in increased susceptibility to 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione" | 21964476 |
| C532666 | 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione | "Dexamethasone promotes the reaction [CYP3A4 protein results in increased susceptibility to 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione]" | 21964476 |
| C532666 | 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione]" | 21964476 |
| C010642 | 3,3',5-triiodothyroacetic acid | "[3,3',5-triiodothyroacetic acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA" | 25455453 |
| C016392 | 3,3'-diindolylmethane | "3,3'-diindolylmethane results in decreased activity of CYP3A4 protein" | 19770484 |
| C016392 | 3,3'-diindolylmethane | "[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA" | 25542144 |
| C016392 | 3,3'-diindolylmethane | "3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA" | 25542144 |
| C016392 | 3,3'-diindolylmethane | "Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]" | 25542144 |
| C509288 | 3',4'-dimethoxyflavone | "3',4'-dimethoxyflavone results in decreased activity of CYP3A4 protein" | 21053930 |
| C012587 | 3,5,6-trichloro-2-pyridinol | "CYP3A4 results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol" | 20709133 |
| C068923 | 3,6-dinitrobenzopyrene | "CYP3A4 protein results in increased metabolism of 3,6-dinitrobenzopyrene" | 19393727 |
| C571631 | 3-bromomethcathinone | CYP3A4 protein results in increased metabolism of 3-bromomethcathinone | 27320963 |
| C041477 | 3-hydroxyflavone | 3-hydroxyflavone results in decreased activity of CYP3A4 protein | 21053930 |
| C041477 | 3-hydroxyflavone | 3-hydroxyflavone results in increased expression of CYP3A4 mRNA | 26238175 |
| C013569 | 3-hydroxyquinidine | CYP3A4 protein affects the chemical synthesis of 3-hydroxyquinidine | 15896247 |
| C545376 | 3-ketocholanoic acid | [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of 3-ketocholanoic acid | 19487251 |
| C455860 | 3-ketolithocholic acid | 3-ketolithocholic acid results in increased expression of CYP3A4 mRNA | 17965521 |
| C028657 | 3-methoxymorphinan | CYP3A4 protein affects the chemical synthesis of 3-methoxymorphinan | 15988119 |
| C028657 | 3-methoxymorphinan | [CYP3A4 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of 3-methoxymorphinan | 21606622 |
| C047368 | 3-methylquercetin | 3-methylquercetin results in increased expression of CYP3A4 mRNA | 26238175 |
| C064809 | 3-phenoxybenzylalcohol | CYP3A4 protein results in increased abundance of 3-phenoxybenzylalcohol | 24548679 |
| C102050 | 3'-p-hydroxypaclitaxel | CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel | 12237780 |
| C102050 | 3'-p-hydroxypaclitaxel | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel] | 12237780 |
| C008745 | 4,4'-bisphenol F | "CYP3A4 protein results in increased glutathionylation of 4,4'-bisphenol F" | 23470418 |
| C008745 | 4,4'-bisphenol F | "CYP3A4 protein results in increased hydroxylation of 4,4'-bisphenol F" | 23470418 |
| C438583 | 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide | "CYP3A4 protein affects the metabolism of 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide" | 16012074 |
| C438583 | 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide | "CYP3A4 protein results in decreased ethylation of 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide" | 16012074 |
| C570106 | 4,4'-cyclohexylidenebisphenol | "CYP3A4 protein results in increased glutathionylation of 4,4'-cyclohexylidenebisphenol" | 23470418 |
| C570106 | 4,4'-cyclohexylidenebisphenol | "CYP3A4 protein results in increased glutathionylation of 4,4'-cyclohexylidenebisphenol metabolite" | 23470418 |
| C570106 | 4,4'-cyclohexylidenebisphenol | "CYP3A4 protein results in increased hydroxylation of 4,4'-cyclohexylidenebisphenol" | 23470418 |
| C583074 | 4,4'-hexafluorisopropylidene diphenol | "CYP3A4 protein results in increased hydroxylation of 4,4'-hexafluorisopropylidene diphenol" | 23470418 |
| C543441 | 4,4'-methanol-bisbenzonitrile | "CYP3A4 protein results in increased chemical synthesis of 4,4'-methanol-bisbenzonitrile" | 19845430 |
| C545880 | 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide | "CYP3A4 protein results in increased oxidation of and results in increased activity of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide" | 19697924 |
| C545880 | 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide | "[CYP3A4 protein results in increased oxidation of and results in increased activity of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide] which results in increased chemical synthesis of chlorophenyl isocyanate" | 19697924 |
| C545880 | 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide | "Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]" | 19697924 |
| C075205 | 4-bromo-2-chlorophenol | [CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol | 23415833 |
| C025963 | 4-chlorophenylbiguanide | 4-chlorophenylbiguanide results in decreased activity of CYP3A4 protein | 11124226 |
| C516284 | 4-cumylphenol | 4-cumylphenol results in increased expression of CYP3A4 mRNA | 22214767 |
| C018511 | 4-dichlorobenzene | CYP3A4 protein results in increased oxidation of 4-dichlorobenzene | 9817075 |
| C082137 | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide results in increased expression of CYP3A4 mRNA | 15681896 |
| C027576 | 4-hydroxy-2-nonenal | "[[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene" | 21766881 |
| C027576 | 4-hydroxy-2-nonenal | [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal | 21766881 |
| C027576 | 4-hydroxy-2-nonenal | [CYP3A4 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid | 21766881 |
| C091766 | 4-hydroxy-2-nonenoic acid | [CYP3A4 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid | 21766881 |
| C042940 | 4-hydroxymidazolam | acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C042940 | 4-hydroxymidazolam | Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C042940 | 4-hydroxymidazolam | CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| C042940 | 4-hydroxymidazolam | CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam | 12695342|1819110 |
| C042940 | 4-hydroxymidazolam | [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam | 27485346 |
| C042940 | 4-hydroxymidazolam | [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam | 21053930 |
| C042940 | 4-hydroxymidazolam | diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 18191104 |
| C042940 | 4-hydroxymidazolam | flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C042940 | 4-hydroxymidazolam | flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C042940 | 4-hydroxymidazolam | galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C042940 | 4-hydroxymidazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| C042940 | 4-hydroxymidazolam | Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 18191104 |
| C042940 | 4-hydroxymidazolam | Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| C042940 | 4-hydroxymidazolam | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | CYP3A4 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen | 29285606 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | [CYP3A4 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen] which results in increased abundance of 4-hydroxy-N-desmethyltamoxifen metabolite | 29285606 |
| C019429 | 4-hydroxyretinoic acid | CYP3A4 protein results in increased chemical synthesis of 4-hydroxyretinoic acid | 10874126 |
| C059853 | 4'-hydroxywarfarin | [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 20735727 |
| C059853 | 4'-hydroxywarfarin | CYP3A4 protein results in increased chemical synthesis of 4'-hydroxywarfarin | 20429590 |
| C001470 | 4-ipomeanol | CYP3A4 protein results in increased activity of 4-ipomeanol | 15892579 |
| C030438 | 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide | CYP3A4 protein results in increased chemical synthesis of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide | 10901704 |
| C028690 | 4-isopropylphenol | CYP3A4 protein results in increased glutathionylation of 4-isopropylphenol | 23470418 |
| C487850 | 4'-methoxyflavone | 4'-methoxyflavone binds to and results in decreased activity of CYP3A4 protein | 21053930 |
| C099565 | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol | CYP3A4 protein results in increased metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol | 9029045 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | CYP3A4 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 11774366 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | CYP3A4 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 9029045 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | CYP3A4 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 25221795 |
| C002202 | 4-oxoretinoic acid | CYP3A4 protein results in increased chemical synthesis of 4-oxoretinoic acid | 10874126 |
| C502236 | 5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione | "CYP3A4 protein affects the metabolism of 5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione" | 15708677 |
| C040776 | 5,6-epoxy-8,11,14-eicosatrienoic acid | "CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid" | 12675279 |
| C040776 | 5,6-epoxy-8,11,14-eicosatrienoic acid | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]" | 12675279 |
| C117715 | 5-hydroxydiclofenac | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac | 24246759 |
| C117715 | 5-hydroxydiclofenac | [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac | 24246759 |
| C117715 | 5-hydroxydiclofenac | Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] | 24246759 |
| C117715 | 5-hydroxydiclofenac | CYP3A4 protein results in increased abundance of 5-hydroxydiclofenac | 24552538 |
| C062711 | 5-hydroxyflavone | 5-hydroxyflavone results in decreased activity of CYP3A4 protein | 21053930 |
| C093609 | 5-hydroxymethylflucloxacillin | CYP3A4 results in increased abundance of 5-hydroxymethylflucloxacillin | 11409940 |
| C544471 | 5-hydroxythalidomide | [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide | 20443640 |
| C544471 | 5-hydroxythalidomide | CYP3A4 protein results in increased oxidation of and results in increased glutathionylation of 5-hydroxythalidomide | 20443640 |
| C544471 | 5-hydroxythalidomide | [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide | 20443640 |
| C487413 | 5-methoxyindole | 5-methoxyindole results in decreased activity of CYP3A4 protein | 18420780 |
| C547858 | 5-n-butyl-pyrazolo(1,5-a)pyrimidine | "5-n-butyl-pyrazolo(1,5-a)pyrimidine metabolite binds to CYP3A4 protein" | 19928966 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA" | 16608920|1833207 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 protein" | 21227907|2177846 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 25069801 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]" | 25069801 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 24224465 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 21778469 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 protein]" | 21778469 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 16608920 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 24224465 |
| C475093 | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | "NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 25069801 |
| C104774 | 6',7'-dihydroxybergamottin | "6',7'-dihydroxybergamottin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]" | 23146034 |
| C104774 | 6',7'-dihydroxybergamottin | "6',7'-dihydroxybergamottin results in decreased activity of CYP3A4 protein" | 15860655|2314603 |
| C485383 | 6,7-dihydroxyflavone | "6,7-dihydroxyflavone results in decreased activity of CYP3A4 protein" | 21053930 |
| C001380 | 6 beta-hydroxycortisol | CYP3A4 protein affects the chemical synthesis of 6 beta-hydroxycortisol | 15941677 |
| C025591 | 6 beta-hydroxytestosterone | CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone | 12401345|2023384 |
| C025591 | 6 beta-hydroxytestosterone | [CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | 16595712|2823872 |
| C025591 | 6 beta-hydroxytestosterone | [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | 17084830|1913503 |
| C025591 | 6 beta-hydroxytestosterone | fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 17084830 |
| C025591 | 6 beta-hydroxytestosterone | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 20233841|2086332 |
| C025591 | 6 beta-hydroxytestosterone | Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 28238727 |
| C025591 | 6 beta-hydroxytestosterone | [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 6 beta-hydroxytestosterone | 26239802 |
| C025591 | 6 beta-hydroxytestosterone | obeticholic acid inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 27939613 |
| C025591 | 6 beta-hydroxytestosterone | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 20863320 |
| C025591 | 6 beta-hydroxytestosterone | CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone | 27836570 |
| C025591 | 6 beta-hydroxytestosterone | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased chemical synthesis of 6 beta-hydroxytestosterone | 16987939 |
| C025591 | 6 beta-hydroxytestosterone | [CYP3A4 protein mutant form co-treated with NADP] results in increased chemical synthesis of 6 beta-hydroxytestosterone | 16987939 |
| C025591 | 6 beta-hydroxytestosterone | CYP3A4 protein mutant form results in increased chemical synthesis of 6 beta-hydroxytestosterone | 16987939 |
| C100101 | 6-chrysenamine | CYP3A4 protein affects the metabolism of 6-chrysenamine | 2271712|2655891 |
| C066209 | 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine | "7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine results in increased expression of CYP3A4 mRNA" | 21315811 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Amiodarone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Androstenedione promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Benzphetamine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Chenodeoxycholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Chloramphenicol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cholesterol promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cyclosporine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | CYP3A4 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin | 12065433 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Diazepam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Diltiazem inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Erythromycin inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Estrone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Ethinyl Estradiol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Flunitrazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 18206979 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Hexobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Lithocholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Metronidazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Miconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Midazolam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Mifepristone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Nifedipine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Progesterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Raloxifene Hydrochloride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Secobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Sertraline promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Tamoxifen inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Temazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Terfenadine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Ticlopidine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Triazolam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Troleandomycin promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Verapamil inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | alpha-naphthoflavone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Amiodarone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Androstenedione promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Benzphetamine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Chenodeoxycholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Chloramphenicol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cimetidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Cyclosporine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Dexamethasone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Diazepam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Diltiazem inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Erythromycin inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Estrone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Ethinyl Estradiol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Flunitrazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Hexobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Metronidazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Miconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Mifepristone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Nifedipine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Progesterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Raloxifene Hydrochloride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Secobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Tamoxifen promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Temazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Terfenadine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Triazolam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Troleandomycin promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C419147 | 7-benzyloxy-4-trifluoromethylcoumarin | Verapamil inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C065956 | 7-benzyloxyquinoline | CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline | 19299527 |
| C065956 | 7-benzyloxyquinoline | Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline] | 18206979 |
| C065956 | 7-benzyloxyquinoline | CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline | 19299527 |
| C065956 | 7-benzyloxyquinoline | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased metabolism of 7-benzyloxyquinoline | 16987939 |
| C065956 | 7-benzyloxyquinoline | [CYP3A4 protein mutant form co-treated with Hydrogen Peroxide] results in increased metabolism of 7-benzyloxyquinoline | 16987939 |
| C055440 | 7-hydroxyellipticine | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 7-hydroxyellipticine | 22390216 |
| C429845 | 7-hydroxyflavone | 7-hydroxyflavone results in decreased activity of CYP3A4 protein | 21053930 |
| C556297 | 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | "[CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine" | 20825217 |
| C050715 | 8,9-epoxyeicosatrienoic acid | "CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid" | 12675279 |
| C050715 | 8,9-epoxyeicosatrienoic acid | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]" | 12675279 |
| C534602 | 8-epidiosbulbin E acetate | CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate | 26286065 |
| C534602 | 8-epidiosbulbin E acetate | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate] | 26286065 |
| C119737 | 8-prenylnaringenin | 8-prenylnaringenin results in decreased activity of CYP3A4 protein | 19770484 |
| C421010 | 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole | "CYP3A4 protein results in increased chemical synthesis of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole" | 15279827 |
| C031390 | 9-cis-retinal | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C031390 | 9-cis-retinal | "9-cis-retinal promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C031390 | 9-cis-retinal | 9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| C031390 | 9-cis-retinal | 9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter] | 19686701 |
| C031390 | 9-cis-retinal | 9-cis-retinal results in increased activity of CYP3A4 protein | 16632523 |
| C031390 | 9-cis-retinal | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[9-cis-retinal co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C031390 | 9-cis-retinal | [9-cis-retinal co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA | 19686701 |
| C031390 | 9-cis-retinal | "9-cis-retinal promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C031390 | 9-cis-retinal | 9-cis-retinal promotes the reaction [[RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C031390 | 9-cis-retinal | 9-cis-retinal promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C008009 | 9-hydroxyellipticine | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine | 22390216 |
| C023717 | acacetin | acacetin binds to and results in decreased activity of CYP3A4 protein | 21053930 |
| C023717 | acacetin | acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C023717 | acacetin | acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C042553 | acenaphthylene | CYP3A4 protein results in increased oxidation of acenaphthylene | 25642975 |
| D000082 | Acetaminophen | Acetaminophen results in decreased degradation of and results in increased activity of CYP3A4 protein | 11811955 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of CYP3A4 mRNA | 29067470 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of CYP3A4 protein | 29067470 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of CYP3A4 mRNA | 26497421 |
| D000082 | Acetaminophen | CYP3A4 protein promotes the reaction [Acetaminophen results in decreased abundance of Glutathione] | 27485346 |
| D000082 | Acetaminophen | CYP3A4 protein results in increased metabolism of Acetaminophen | 19460945 |
| D000082 | Acetaminophen | CYP3A4 protein results in increased susceptibility to Acetaminophen | 26706816|2671887 |
| D000082 | Acetaminophen | CYP3A4 results in increased metabolism of Acetaminophen | 20566340 |
| D000082 | Acetaminophen | NR1I2 protein affects the reaction [CYP3A4 protein results in increased metabolism of Acetaminophen] | 19460945 |
| D000082 | Acetaminophen | Acetaminophen results in increased activity of CYP3A4 protein | 19932728 |
| D000082 | Acetaminophen | Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein] | 19932728 |
| D000082 | Acetaminophen | [GCSH mRNA co-treated with CYP3A4 protein] affects the susceptibility to Acetaminophen | 19958826 |
| C043377 | acetochlor | CYP3A4 protein results in increased metabolism of acetochlor | 11133395 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione] | 25451576 |
| D000111 | Acetylcysteine | [CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite | 27989148 |
| D000111 | Acetylcysteine | Acetylcysteine affects the reaction [[CYP3A4 protein co-treated with NADP] results in increased metabolism of Erlotinib Hydrochloride] | 21395287 |
| D000111 | Acetylcysteine | Acetylcysteine affects the reaction [[CYP3A4 protein co-treated with NADP] results in increased metabolism of Isoquinolines] | 21395287 |
| C473838 | acetyl triethyl citrate | acetyl triethyl citrate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21742782 |
| D000157 | Aconitine | CYP3A4 protein results in increased metabolism of Aconitine | 21277363 |
| D000157 | Aconitine | [CYP3A4 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine | 21277363 |
| C106812 | adefovir dipivoxil | adefovir dipivoxil results in decreased activity of CYP3A4 protein | 17162464 |
| C039668 | adinazolam | CYP3A4 protein results in decreased methylation of adinazolam | 9600717 |
| C039668 | adinazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam] | 9600717 |
| C039668 | adinazolam | Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam] | 9600717 |
| C016601 | afimoxifene | afimoxifene results in decreased activity of CYP3A4 protein | 12419016 |
| C016601 | afimoxifene | afimoxifene results in increased activity of CYP3A4 protein | 29285606 |
| C016601 | afimoxifene | afimoxifene results in increased expression of CYP3A4 mRNA | 29285606 |
| C016601 | afimoxifene | CYP3A4 protein results in increased metabolism of afimoxifene | 29285606 |
| C016601 | afimoxifene | [CYP3A4 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite | 29285606 |
| C016601 | afimoxifene | [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene | 20507880 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of CYP3A4 protein | 20106945 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] | 21641981 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of CYP3A4 mRNA | 22100608|2715375 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of CYP3A4 protein | 18347083 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased expression of CYP3A4 mRNA | 21641981|2199423 |
| D016604 | Aflatoxin B1 | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B1 | 23397584 |
| D016604 | Aflatoxin B1 | CYP3A4 protein affects the metabolism of Aflatoxin B1 | 2271712|2655891 |
| D016604 | Aflatoxin B1 | CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] | 21907773 |
| D016604 | Aflatoxin B1 | CYP3A4 protein promotes the reaction [Aflatoxin B1 results in increased activity of TP53 protein] | 20655369 |
| D016604 | Aflatoxin B1 | CYP3A4 protein results in increased activity of Aflatoxin B1 | 15988000 |
| D016604 | Aflatoxin B1 | CYP3A4 protein results in increased metabolism of Aflatoxin B1 | 20707407 |
| D016604 | Aflatoxin B1 | "[CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide" | 20707407 |
| D016604 | Aflatoxin B1 | [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin Q1 | 20707407 |
| D016604 | Aflatoxin B1 | CYP3A4 protein results in increased susceptibility to Aflatoxin B1 | 11189750 |
| D016604 | Aflatoxin B1 | [POR protein co-treated with CYP3A4 protein] results in increased susceptibility to Aflatoxin B1 | 27913846 |
| D016604 | Aflatoxin B1 | CYP3A4 protein results in increased metabolism of Aflatoxin B1 | 19146867 |
| C006426 | aflatoxin B1-2,3-oxide | "[CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide" | 20707407 |
| C006426 | aflatoxin B1-2,3-oxide | "CYP3A4 protein results in increased chemical synthesis of aflatoxin B1-2,3-oxide analog" | 19146867 |
| C027955 | aflatoxin G1 | aflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] | 21641981 |
| C027955 | aflatoxin G1 | aflatoxin G1 results in increased expression of CYP3A4 mRNA | 21641981 |
| C027955 | aflatoxin G1 | CYP3A4 protein affects the metabolism of aflatoxin G1 | 2271712|2655891 |
| C027955 | aflatoxin G1 | CYP3A4 protein results in increased susceptibility to aflatoxin G1 | 11189750 |
| D016607 | Aflatoxin M1 | Aflatoxin M1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] | 21641981 |
| D016607 | Aflatoxin M1 | Aflatoxin M1 results in increased expression of CYP3A4 mRNA | 21641981 |
| C033759 | aflatoxin Q1 | [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin Q1 | 20707407 |
| C033759 | aflatoxin Q1 | CYP3A4 protein results in increased chemical synthesis of aflatoxin Q1 | 19146867 |
| C000188 | alachlor | alachlor results in increased expression of CYP3A4 mRNA | 16565514 |
| C000188 | alachlor | CYP3A4 protein results in increased metabolism of alachlor | 10475613|1827390 |
| C000188 | alachlor | "[CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide" | 18273908 |
| C000188 | alachlor | CYP3A4 protein results in decreased alkylation of alachlor | 17207564 |
| D015766 | Albendazole | [Albendazole co-treated with CYP3A4 protein] results in increased expression of CD86 protein | 22785256 |
| D015766 | Albendazole | [Albendazole co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein | 22785256 |
| D015766 | Albendazole | [SOD2 co-treated with CYP3A4] affects the susceptibility to Albendazole | 19501153 |
| D000438 | Alcohols | Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA] | 24025710 |
| D000438 | Alcohols | Alcohols promotes the reaction [ferric citrate results in increased expression of CYP3A4 protein] | 24025710 |
| D000438 | Alcohols | Alcohols results in increased expression of CYP3A4 mRNA | 24025710 |
| D000438 | Alcohols | Alcohols results in increased expression of CYP3A4 protein | 24025710 |
| D000438 | Alcohols | ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP3A4 mRNA] | 24025710 |
| D000438 | Alcohols | ferric citrate promotes the reaction [Alcohols results in increased expression of CYP3A4 protein] | 24025710 |
| D000452 | Aldrin | Aldrin results in increased expression of CYP3A4 protein | 15548381 |
| C008088 | alfacalcidol | CYP3A4 protein results in increased hydroxylation of alfacalcidol | 15005856 |
| D015760 | Alfentanil | CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil] | 15557344 |
| D015760 | Alfentanil | CYP3A4 protein affects the metabolism of Alfentanil | 15557344|1573159 |
| C103303 | alitretinoin | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C103303 | alitretinoin | "alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]" | 19686701 |
| C103303 | alitretinoin | alitretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| C103303 | alitretinoin | alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter] | 19686701 |
| C103303 | alitretinoin | alitretinoin results in increased activity of CYP3A4 protein | 16632523 |
| C103303 | alitretinoin | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[alitretinoin co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C103303 | alitretinoin | [alitretinoin co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA | 19686701 |
| C103303 | alitretinoin | "alitretinoin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| C103303 | alitretinoin | alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which results in increased expression of CYP3A4 mRNA] | 19686701 |
| C103303 | alitretinoin | alitretinoin promotes the reaction [[RXRA protein binds to RXRA protein] which results in increased expression of CYP3A4 mRNA] | 19686701 |
| C103303 | alitretinoin | alitretinoin promotes the reaction [[RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C103303 | alitretinoin | alitretinoin promotes the reaction [[RXRB protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C103303 | alitretinoin | alitretinoin promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C004471 | allyl isothiocyanate | "allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C004471 | allyl isothiocyanate | "allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]" | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [SR 12813 results in increased expression of CYP3A4 mRNA] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate results in decreased activity of CYP3A4 protein | 25069801 |
| C004471 | allyl isothiocyanate | allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA] | 25069801 |
| C054528 | allyl methyl disulfide | allyl methyl disulfide inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| C054528 | allyl methyl disulfide | allyl methyl disulfide results in decreased activity of CYP3A4 protein | 18385293 |
| C409045 | almotriptan | CYP3A4 protein results in decreased methylation of almotriptan | 12642466 |
| C409045 | almotriptan | CYP3A4 protein results in increased hydroxylation of almotriptan | 12642466 |
| C090840 | alosetron | CYP3A4 affects the metabolism of alosetron | 11304902|1130490 |
| C032318 | alpha-hydroxyalprazolam | CYP3A4 protein affects the chemical synthesis of alpha-hydroxyalprazolam | 12196913 |
| D017962 | alpha-Linolenic Acid | alpha-Linolenic Acid results in decreased activity of CYP3A4 protein | 16978661 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone binds to and results in decreased activity of CYP3A4 protein | 21053930 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone binds to CYP3A4 protein | 17198380 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | 19299527 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] | 1740010 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone results in decreased activity of CYP3A4 protein | 15005856 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone results in increased activity of CYP3A4 protein | 2271712 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone promotes the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | 19299527 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D024502 | alpha-Tocopherol | alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CYP3A4 mRNA] | 17936189 |
| D024502 | alpha-Tocopherol | alpha-Tocopherol results in increased expression of CYP3A4 mRNA | 17936189 |
| D024502 | alpha-Tocopherol | Galactosamine inhibits the reaction [alpha-Tocopherol results in increased expression of CYP3A4 mRNA] | 17936189 |
| D000525 | Alprazolam | CYP3A4 protein affects the metabolism of Alprazolam | 12196913|1604267 |
| D000525 | Alprazolam | CYP3A4 protein binds to and affects the metabolism of Alprazolam | 15856409 |
| D000525 | Alprazolam | CYP3A4 affects the metabolism of Alprazolam | 11304902 |
| D000638 | Amiodarone | [Amiodarone co-treated with CYP3A4 protein] results in increased expression of CD86 protein | 22785256 |
| D000638 | Amiodarone | [Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA | 22785256 |
| D000638 | Amiodarone | [Amiodarone co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein | 22785256 |
| D000638 | Amiodarone | [Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA | 22785256 |
| D000638 | Amiodarone | [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of CXCL8 protein | 22785256 |
| D000638 | Amiodarone | [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of TNF protein | 22785256 |
| D000638 | Amiodarone | Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 22652334 |
| D000638 | Amiodarone | Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 22652334 |
| D000638 | Amiodarone | Amiodarone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D000638 | Amiodarone | Amiodarone results in decreased activity of CYP3A4 protein | 15304522|1644981 |
| D000638 | Amiodarone | CYP3A4 protein results in decreased ethylation of Amiodarone | 7905403 |
| D000638 | Amiodarone | CYP3A4 protein results in increased metabolism of Amiodarone | 15869686|1644981 |
| D000638 | Amiodarone | [CYP3A4 protein results in increased metabolism of Amiodarone] which results in increased abundance of mono-N-desethylamiodarone | 27485346 |
| D000638 | Amiodarone | CYP3A4 protein results in increased susceptibility to Amiodarone | 21540358|2647738 |
| D000638 | Amiodarone | Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA] | 22785256 |
| D000638 | Amiodarone | Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA] | 22785256 |
| D000638 | Amiodarone | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone] | 15869686 |
| D000638 | Amiodarone | Amiodarone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D000638 | Amiodarone | Amiodarone results in increased expression of CYP3A4 mRNA | 19224547 |
| D000638 | Amiodarone | Amiodarone results in decreased activity of CYP3A4 protein | 16537817|1761542 |
| D000638 | Amiodarone | CYP3A4 protein results in increased metabolism of Amiodarone | 11231118 |
| D000639 | Amitriptyline | Amitriptyline results in increased metabolism of CYP3A4 protein | 18359012 |
| D000639 | Amitriptyline | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline | 23397584 |
| D000655 | Amodiaquine | CYP3A4 protein results in increased metabolism of Amodiaquine | 28478157 |
| D000655 | Amodiaquine | [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| C094705 | amodiaquine quinoneimine | CYP3A4 protein results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| C094705 | amodiaquine quinoneimine | [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine | 28478157 |
| D000657 | Amoxapine | CYP3A4 results in increased chemical synthesis of Amoxapine | 21826677 |
| D000661 | Amphetamine | Amphetamine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21402137 |
| D000661 | Amphetamine | CYP3A4 protein affects the chemical synthesis of Amphetamine | 15294457 |
| D000661 | Amphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Amphetamine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| C095108 | amprenavir | amprenavir results in decreased activity of CYP3A4 protein | 15523003 |
| C030419 | andrographolide | andrographolide results in decreased expression of CYP3A4 mRNA | 19041297 |
| D000735 | Androstenedione | Androstenedione promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D000735 | Androstenedione | Androstenedione promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C023650 | aniline | CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] | 15279827 |
| D000927 | Anticonvulsants | Anticonvulsants results in increased expression of CYP3A4 protein | 19490052 |
| D018501 | Antirheumatic Agents | Antirheumatic Agents results in decreased expression of CYP3A4 mRNA | 24449571 |
| D047310 | Apigenin | Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| D047310 | Apigenin | Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| D047310 | Apigenin | Apigenin results in decreased activity of CYP3A4 protein | 21053930 |
| C114556 | aprepitant | aprepitant results in decreased activity of CYP3A4 protein | 21112467 |
| D016718 | Arachidonic Acid | Arachidonic Acid results in decreased activity of CYP3A4 protein | 16978661 |
| D016718 | Arachidonic Acid | CYP3A4 protein results in increased metabolism of Arachidonic Acid | 12675279 |
| D016718 | Arachidonic Acid | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid] | 12675279 |
| D000068180 | Aripiprazole | CYP3A4 protein affects the metabolism of Aripiprazole | 17110829|1848069 |
| D001140 | Aroclors | Aroclors results in increased expression of CYP3A4 protein | 29162470 |
| D001151 | Arsenic | Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein] | 19932728 |
| D001151 | Arsenic | Arsenic results in decreased activity of CYP3A4 protein | 19932728 |
| C006632 | arsenic trioxide | arsenic trioxide inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 16184197 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased expression of CYP3A4 mRNA | 20458559 |
| C031327 | artemisinine | [artemisinine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| C031327 | artemisinine | artemisinine results in increased expression of CYP3A4 mRNA | 15761118|1833207 |
| C031327 | artemisinine | CYP3A4 protein affects the metabolism of artemisinine | 12920490 |
| C004446 | asiaticoside | asiaticoside results in decreased activity of CYP3A4 protein | 21349323 |
| D016589 | Astemizole | CYP3A4 protein results in increased degradation of Astemizole | 15684493 |
| D016589 | Astemizole | CYP3A4 protein results in increased metabolism of Astemizole | 12052668 |
| D000069446 | Atazanavir Sulfate | Atazanavir Sulfate results in decreased activity of CYP3A4 protein | 17615423 |
| D000069446 | Atazanavir Sulfate | CYP3A4 protein results in increased metabolism of Atazanavir Sulfate | 17053366 |
| D000069059 | Atorvastatin Calcium | ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Atorvastatin Calcium] | 19802823 |
| D000069059 | Atorvastatin Calcium | Atorvastatin Calcium inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] | 16029222 |
| D000069059 | Atorvastatin Calcium | Atorvastatin Calcium results in decreased activity of CYP3A4 protein | 16029222 |
| D000069059 | Atorvastatin Calcium | Atorvastatin Calcium results in increased expression of CYP3A4 protein | 26616219 |
| D000069059 | Atorvastatin Calcium | CYP3A4 polymorphism affects the susceptibility to Atorvastatin Calcium | 18528690|1980282 |
| D000069059 | Atorvastatin Calcium | CYP3A4 protein affects the metabolism of Atorvastatin Calcium | 15963098|1601197 |
| D000069059 | Atorvastatin Calcium | CYP3A4 protein results in increased metabolism of Atorvastatin Calcium | 18846481 |
| D000069059 | Atorvastatin Calcium | CYP3A4 protein affects the metabolism of Atorvastatin Calcium | 11959068 |
| D000069059 | Atorvastatin Calcium | CYP3A4 protein results in increased metabolism of Atorvastatin Calcium | 12243603|1844034 |
| D000069059 | Atorvastatin Calcium | CYP3A4 results in increased metabolism of Atorvastatin Calcium | 19802823 |
| D001280 | Atrazine | [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein | 22515965 |
| D001280 | Atrazine | Atrazine results in decreased activity of CYP3A4 protein | 20183062 |
| D001280 | Atrazine | Atrazine results in increased activity of CYP3A4 protein | 22310298 |
| D001280 | Atrazine | Atrazine results in increased expression of CYP3A4 mRNA | 22310298|2434334 |
| D001280 | Atrazine | [Endosulfan co-treated with Atrazine] results in increased expression of CYP3A4 mRNA | 24343343 |
| D001280 | Atrazine | [Endosulfan co-treated with Chlorpyrifos co-treated with Atrazine] results in increased expression of CYP3A4 mRNA | 24343343 |
| C423185 | avasimibe | avasimibe results in increased activity of and results in increased expression of CYP3A4 protein | 19202563 |
| C423185 | avasimibe | avasimibe results in increased expression of CYP3A4 mRNA | 16837568 |
| C423185 | avasimibe | avasimibe results in increased expression of CYP3A4 | 15333513 |
| D001374 | Azacitidine | Azacitidine results in increased expression of CYP3A4 mRNA | 27590069 |
| C489644 | azamulin | azamulin results in decreased activity of CYP3A4 protein | 15860655 |
| C020976 | azelastine | CYP3A4 protein results in increased metabolism of azelastine | 11231118 |
| D017963 | Azithromycin | Azithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D017963 | Azithromycin | Azithromycin results in decreased activity of CYP3A4 protein | 16416302 |
| D001393 | Azoles | [Azoles affects the activity of NR1I2 protein] which affects the expression of CYP3A4 | 21333771 |
| D001393 | Azoles | Azoles results in decreased activity of CYP3A4 protein | 21333771 |
| C087670 | azoxystrobin | [azoxystrobin co-treated with cyproconazole] results in increased expression of CYP3A4 protein | 29294346 |
| C087670 | azoxystrobin | azoxystrobin results in increased expression of CYP3A4 mRNA | 29294346 |
| C087670 | azoxystrobin | [cyproconazole co-treated with azoxystrobin] results in increased expression of CYP3A4 mRNA | 29294346 |
| C006680 | baicalein | baicalein results in decreased activity of CYP3A4 protein | 21053930 |
| C006680 | baicalein | baicalein results in increased expression of CYP3A4 mRNA | 25625231 |
| D001463 | Barbiturates | Barbiturates results in increased expression of CYP3A4 | 15554232|1595587 |
| D001507 | Beclomethasone | CYP3A4 protein results in increased metabolism of Beclomethasone | 23512537 |
| C096128 | benfuracarb | benfuracarb results in increased activity of CYP3A4 protein | 22310298 |
| C096128 | benfuracarb | benfuracarb results in increased expression of CYP3A4 mRNA | 22310298 |
| C096128 | benfuracarb | CYP3A4 protein results in increased metabolism of benfuracarb | 24016712 |
| C096128 | benfuracarb | [CYP3A4 protein results in increased metabolism of benfuracarb] which results in increased chemical synthesis of Carbofuran | 24016712 |
| C061004 | benidipine | benidipine results in decreased activity of CYP3A4 protein | 10805063 |
| C061004 | benidipine | benidipine results in increased expression of and results in decreased activity of CYP3A4 protein | 27732883 |
| C061004 | benidipine | benidipine results in increased expression of CYP3A4 mRNA | 27732883 |
| C015149 | benzanthracene-3,4-dihydrodiol | "CYP3A4 protein affects the metabolism of benzanthracene-3,4-dihydrodiol" | 2271712 |
| C017228 | benzo(a)pyrene 7,8-dihydrodiol | "[benzo(a)pyrene 7,8-dihydrodiol binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA" | 23845848 |
| C017228 | benzo(a)pyrene 7,8-dihydrodiol | "CYP3A4 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol" | 2271712|2655891 |
| C017228 | benzo(a)pyrene 7,8-dihydrodiol | "CYP3A4 protein results in increased metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol" | 2509067 |
| C017228 | benzo(a)pyrene 7,8-dihydrodiol | "[CYP3A4 protein results in increased metabolism of Benzo(a)pyrene] which results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol" | 2509067 |
| C002615 | benzo(c)phenanthrene | [benzo(c)phenanthrene binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 23845848 |
| C026153 | benzo(c)phenanthrene 3,4-dihydrodiol | "[benzo(c)phenanthrene 3,4-dihydrodiol binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA" | 23845848 |
| D019324 | beta-Naphthoflavone | beta-Naphthoflavone binds to CYP3A4 protein | 21053930 |
| D019324 | beta-Naphthoflavone | beta-Naphthoflavone results in decreased expression of CYP3A4 mRNA | 16837568|1698516 |
| D019324 | beta-Naphthoflavone | beta-Naphthoflavone results in increased expression of CYP3A4 mRNA | 22258563 |
| D001564 | Benzo(a)pyrene | [Benzo(a)pyrene binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 23845848 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of CYP3A4 mRNA | 16545412 |
| D001564 | Benzo(a)pyrene | CYP3A4 protein results in increased metabolism of Benzo(a)pyrene | 2509067 |
| D001564 | Benzo(a)pyrene | "[CYP3A4 protein results in increased metabolism of Benzo(a)pyrene] which results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol" | 2509067 |
| D001564 | Benzo(a)pyrene | [[POR protein co-treated with CYP3A4 protein] results in increased susceptibility to Benzo(a)pyrene] which results in increased mutagenesis of HPRT1 gene | 27913846 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "[7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA" | 23845848 |
| D001589 | Benzphetamine | Benzphetamine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D001589 | Benzphetamine | Benzphetamine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | "benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 24224465 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 24224465 |
| C057754 | benzyloxyresorufin | CYP3A4 protein affects the metabolism of benzyloxyresorufin | 14508638 |
| D015764 | Bepridil | CYP3A4 protein affects the metabolism of Bepridil | 15286053 |
| C027870 | berbamine | CYP3A4 protein results in increased metabolism of berbamine | 27902864 |
| D001599 | Berberine | [Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 21524698 |
| C068337 | bergamottin | bergamottin results in decreased activity of CYP3A4 protein | 11451028|1586065 |
| C068337 | bergamottin | bergamottin results in increased expression of CYP3A4 mRNA | 19148864 |
| D019207 | beta Carotene | beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| D004958 | Estradiol | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| D004958 | Estradiol | CYP3A4 promoter mutant form inhibits the reaction [Estradiol results in increased expression of CYP3A4 mRNA] | 12505310|1250531 |
| D004958 | Estradiol | CYP3A4 protein affects the hydroxylation of Estradiol | 2271712 |
| D004958 | Estradiol | CYP3A4 protein results in increased hydroxylation of Estradiol | 9047321|9714305 |
| D004958 | Estradiol | CYP3A4 protein results in increased metabolism of Estradiol | 16790556 |
| D004958 | Estradiol | decamethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| D004958 | Estradiol | Estradiol binds to CYP3A4 protein | 9047321 |
| D004958 | Estradiol | Estradiol results in increased expression of CYP3A4 mRNA | 12505310|1565001 |
| D004958 | Estradiol | Estradiol results in increased expression of CYP3A4 protein | 15650019 |
| D004958 | Estradiol | Fonofos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| D004958 | Estradiol | Permethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| C099952 | bifenthrin | bifenthrin results in increased expression of CYP3A4 mRNA | 19249324 |
| C036596 | bifonazole | bifonazole results in decreased activity of CYP3A4 protein | 15135088 |
| D001663 | Bilirubin | Bilirubin results in increased expression of CYP3A4 mRNA | 15382119 |
| D001663 | Bilirubin | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA] | 15382119 |
| C018465 | bioallethrin | bioallethrin results in increased expression of CYP3A4 mRNA | 19249324 |
| C018465 | bioallethrin | CYP3A4 protein results in increased metabolism of bioallethrin | 19249324 |
| C002842 | bioresmethrin | bioresmethrin results in increased expression of CYP3A4 mRNA | 19249324 |
| C576262 | bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate | "bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate metabolite results in increased expression of CYP3A4 mRNA" | 27506419 |
| C576262 | bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate | "bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate results in increased expression of CYP3A4 mRNA" | 27506419 |
| C543008 | bis(4-hydroxyphenyl)sulfone | bis(4-hydroxyphenyl)sulfone affects the reaction [SR 12813 results in increased expression of CYP3A4 protein] | 28916285 |
| C543008 | bis(4-hydroxyphenyl)sulfone | CYP3A4 protein results in increased hydroxylation of bis(4-hydroxyphenyl)sulfone | 27213244 |
| C006780 | bisphenol A | bisphenol A affects the expression of CYP3A4 mRNA | 24793377 |
| C006780 | bisphenol A | [bisphenol A binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA | 12851153|1285115 |
| C006780 | bisphenol A | bisphenol A promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 11581012 |
| C006780 | bisphenol A | bisphenol A results in increased activity of CYP3A4 protein | 23384967 |
| C006780 | bisphenol A | bisphenol A results in increased expression of CYP3A4 mRNA | 15650019|2221476 |
| C006780 | bisphenol A | bisphenol A results in increased expression of CYP3A4 protein | 15650019|2619622 |
| C006780 | bisphenol A | CYP3A4 protein results in increased glutathionylation of bisphenol A | 23470418 |
| C006780 | bisphenol A | CYP3A4 protein results in increased glutathionylation of bisphenol A metabolite | 23470418 |
| C006780 | bisphenol A | CYP3A4 protein results in increased hydroxylation of bisphenol A | 23470418 |
| C006780 | bisphenol A | CYP3A4 protein results in increased hydroxylation of bisphenol A metabolite | 23470418 |
| C006780 | bisphenol A | CYP3A4 protein results in increased metabolism of bisphenol A | 21402134 |
| C006780 | bisphenol A | [CYP3A4 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone | 21402134 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of CYP3A4 mRNA | 25181051 |
| C492482 | bisphenol B | bisphenol B results in increased expression of CYP3A4 mRNA | 22214767 |
| D000069286 | Bortezomib | CYP3A4 protein affects the metabolism of Bortezomib | 15764713 |
| C086232 | bosentan | bosentan results in increased expression of CYP3A4 mRNA | 18332078 |
| C086232 | bosentan | bosentan results in increased expression of CYP3A4 | 16550733 |
| C025191 | bromodichloromethane | CYP3A4 protein results in increased metabolism of bromodichloromethane | 12076521 |
| D001971 | Bromocriptine | Bromocriptine binds to CYP3A4 protein | 17198380 |
| D001971 | Bromocriptine | Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D001971 | Bromocriptine | CYP3A4 protein affects the metabolism of Bromocriptine | 15286053 |
| D001971 | Bromocriptine | Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C020960 | brotizolam | CYP3A4 protein affects the metabolism of brotizolam | 16042670 |
| C020960 | brotizolam | Erythromycin inhibits the reaction [CYP3A4 protein affects the metabolism of brotizolam] | 16042670 |
| C083806 | brucine | brucine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 23707193 |
| C083806 | brucine | CYP3A4 protein results in increased metabolism of brucine | 23707193 |
| C083806 | brucine | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of brucine | 23707193 |
| D019819 | Budesonide | [Budesonide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D019819 | Budesonide | Budesonide results in increased expression of CYP3A4 mRNA | 19562681 |
| C022777 | bufalin | bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| C022777 | bufalin | bufalin results in increased expression of and results in increased activity of CYP3A4 protein | 22178124 |
| C022777 | bufalin | bufalin results in increased expression of CYP3A4 mRNA | 22178124 |
| C022777 | bufalin | CYP3A4 protein results in increased metabolism of bufalin | 22178124 |
| C022777 | bufalin | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin] | 22178124 |
| C005734 | bufogenin | bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| C005734 | bufogenin | bufogenin results in increased activity of CYP3A4 protein | 22178124 |
| C005734 | bufogenin | bufogenin results in increased expression of CYP3A4 mRNA | 22178124 |
| C005734 | bufogenin | CYP3A4 protein results in increased metabolism of bufogenin | 22178124 |
| C005734 | bufogenin | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin] | 22178124 |
| D002047 | Buprenorphine | Buprenorphine results in decreased activity of CYP3A4 protein | 12756210 |
| D002047 | Buprenorphine | CYP3A4 protein affects the metabolism of Buprenorphine | 16010532 |
| D002047 | Buprenorphine | CYP3A4 protein results in decreased alkylation of Buprenorphine | 15966752 |
| D002047 | Buprenorphine | CYP3A4 protein results in increased metabolism of Buprenorphine | 12756210 |
| D002047 | Buprenorphine | CYP3A4 protein results in increased metabolism of Buprenorphine | 18294936 |
| D002065 | Buspirone | CYP3A4 protein results in increased metabolism of Buspirone | 20716633 |
| D002065 | Buspirone | CYP3A4 protein results in increased oxidation of Buspirone | 15640381 |
| D002065 | Buspirone | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Buspirone] | 20716633 |
| C054409 | butachlor | CYP3A4 protein results in increased metabolism of butachlor | 11133395 |
| D019328 | Buthionine Sulfoximine | Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione] | 25451576 |
| D019328 | Buthionine Sulfoximine | [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione | 25451576 |
| D019328 | Buthionine Sulfoximine | neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] | 25451576 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene results in increased expression of CYP3A4 mRNA | 18570159 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene affects the activity of CYP3A4 protein | 18177683 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in increased expression of CYP3A4 mRNA | 18804290 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased expression of CYP3A4 mRNA | 24794047 |
| D019256 | Cadmium Chloride | Cadmium Chloride affects the expression of CYP3A4 mRNA | 18804290 |
| D002110 | Caffeine | Caffeine results in decreased activity of CYP3A4 protein | 24211539 |
| D002110 | Caffeine | Caffeine results in decreased activity of CYP3A4 protein | 18420780 |
| D002185 | Cannabidiol | Cannabidiol results in decreased activity of CYP3A4 protein | 24667653 |
| D002211 | Capsaicin | Capsaicin results in decreased activity of CYP3A4 protein | 20388821 |
| D002215 | Captan | "[Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA" | 25028461 |
| D002220 | Carbamazepine | Carbamazepine promotes the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate] | 16390352 |
| D002220 | Carbamazepine | Carbamazepine results in increased activity of CYP3A4 protein | 12065438|9512926 |
| D002220 | Carbamazepine | Carbamazepine results in increased expression of CYP3A4 mRNA | 10219967|1250531 |
| D002220 | Carbamazepine | Carbamazepine results in increased expression of CYP3A4 protein | 22524704 |
| D002220 | Carbamazepine | [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D002220 | Carbamazepine | [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| D002220 | Carbamazepine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Carbamazepine | 23397584 |
| D002220 | Carbamazepine | CYP3A4 protein affects the metabolism of Carbamazepine | 15286053|1591535 |
| D002220 | Carbamazepine | CYP3A4 protein results in increased metabolism of Carbamazepine | 12606595|1925594 |
| D002220 | Carbamazepine | [CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide | 12606595 |
| D002220 | Carbamazepine | felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] | 12606595 |
| D002220 | Carbamazepine | NR3C1 protein promotes the reaction [Carbamazepine results in increased expression of CYP3A4 mRNA] | 10219967 |
| D002220 | Carbamazepine | Probenecid promotes the reaction [CYP3A4 protein affects the metabolism of Carbamazepine] | 15915352 |
| D002220 | Carbamazepine | [SOD2 co-treated with CYP3A4] affects the susceptibility to Carbamazepine | 19501153 |
| D002220 | Carbamazepine | Carbamazepine affects the reaction [CYP3A4 protein results in increased metabolism of Nimodipine] | 16269628 |
| D002220 | Carbamazepine | [Carbamazepine binds to NR1I2 protein] which results in increased expression of CYP3A4 | 15371980 |
| D002220 | Carbamazepine | Carbamazepine results in increased expression of CYP3A4 | 15708356 |
| D002220 | Carbamazepine | Carbamazepine results in increased expression of CYP3A4 protein | 19934718 |
| D002220 | Carbamazepine | CYP3A4 protein affects the metabolism of Carbamazepine | 10466905|1119757 |
| D002220 | Carbamazepine | CYP3A4 protein results in increased metabolism of Carbamazepine | 10907977 |
| C012227 | carbamazepine epoxide | CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide | 15915352 |
| C012227 | carbamazepine epoxide | [CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide | 12606595 |
| C012227 | carbamazepine epoxide | felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] | 12606595 |
| C012227 | carbamazepine epoxide | Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide] | 15915352 |
| D012721 | Carbaryl | Carbaryl results in increased expression of CYP3A4 mRNA | 22310298 |
| C006698 | carbendazim | carbendazim results in increased expression of CYP3A4 mRNA | 22310298 |
| D002235 | Carbofuran | Carbofuran promotes the reaction [CYP3A4 protein affects the metabolism of Testosterone] | 15560889 |
| D002235 | Carbofuran | Carbofuran results in increased activity of CYP3A4 protein | 22310298 |
| D002235 | Carbofuran | Carbofuran results in increased expression of CYP3A4 mRNA | 22310298 |
| D002235 | Carbofuran | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran] | 15560889 |
| D002235 | Carbofuran | CYP3A4 protein results in increased chemical synthesis of Carbofuran | 24016712 |
| D002235 | Carbofuran | CYP3A4 protein results in increased hydroxylation of Carbofuran | 15560889 |
| D002235 | Carbofuran | [CYP3A4 protein results in increased metabolism of benfuracarb] which results in increased chemical synthesis of Carbofuran | 24016712 |
| D002235 | Carbofuran | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran] | 15560889 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in decreased expression of CYP3A4 mRNA | 19224547 |
| C035038 | carbosulfan | carbosulfan results in decreased activity of CYP3A4 protein | 20307514 |
| C035038 | carbosulfan | carbosulfan results in increased activity of CYP3A4 protein | 22310298 |
| C035038 | carbosulfan | carbosulfan results in increased expression of CYP3A4 mRNA | 22310298 |
| C035038 | carbosulfan | CYP3A4 protein results in increased metabolism of and results in increased activity of carbosulfan | 20307514 |
| C035038 | carbosulfan | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan] | 20307514 |
| D002330 | Carmustine | CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] | 16087946 |
| C024714 | caryophyllene | caryophyllene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D002433 | Cefaclor | Cefaclor results in increased expression of CYP3A4 mRNA | 18505790 |
| D002433 | Cefaclor | Cefaclor results in increased expression of CYP3A4 protein | 18505790 |
| D002434 | Cefadroxil | Cefadroxil results in increased expression of CYP3A4 mRNA | 18505790 |
| D002434 | Cefadroxil | Cefadroxil results in increased expression of CYP3A4 protein | 18505790 |
| C088453 | Celsior | [Celsior co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA | 15448115 |
| C088453 | Celsior | Celsior results in decreased activity of CYP3A4 protein | 15448115 |
| C088453 | Celsior | Celsior results in decreased expression of CYP3A4 mRNA | 15448115 |
| C086276 | cerivastatin | CYP3A4 protein results in increased metabolism of cerivastatin | 15365880 |
| C086276 | cerivastatin | CYP3A4 protein results in increased metabolism of cerivastatin | 12243603 |
| D017332 | Cetirizine | Cetirizine analog results in decreased activity of CYP3A4 protein | 15482930 |
| D017332 | Cetirizine | Cetirizine results in decreased activity of CYP3A4 protein | 15482930 |
| D002635 | Chenodeoxycholic Acid | Chenodeoxycholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D002635 | Chenodeoxycholic Acid | Chenodeoxycholic Acid results in decreased expression of CYP3A4 mRNA | 27174168 |
| D002635 | Chenodeoxycholic Acid | Chenodeoxycholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C473711 | Chir 99021 | Chir 99021 results in increased expression of CYP3A4 mRNA | 26259606 |
| D048271 | Chitosan | Chitosan analog results in increased activity of CYP3A4 protein | 20831879 |
| D002701 | Chloramphenicol | Chloramphenicol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D002701 | Chloramphenicol | Chloramphenicol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D002706 | Chlordan | Chlordan promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 12417264 |
| D002706 | Chlordan | Chlordan results in increased expression of CYP3A4 protein | 15548381 |
| D007631 | Chlordecone | Chlordecone results in increased expression of CYP3A4 protein | 15548381 |
| D002709 | Chlorfenvinphos | [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA | 25028461 |
| C057223 | chlorfluazuron | chlorfluazuron results in increased expression of CYP3A4 mRNA | 22310298 |
| D020111 | Chlorodiphenyl (54% Chlorine) | Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A4 mRNA | 17851650 |
| D020111 | Chlorodiphenyl (54% Chlorine) | Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP3A4 mRNA | 18804290 |
| C452229 | chlorophenyl isocyanate | "[CYP3A4 protein results in increased oxidation of and results in increased activity of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide] which results in increased chemical synthesis of chlorophenyl isocyanate" | 19697924 |
| D002738 | Chloroquine | Chloroquine results in decreased activity of CYP3A4 protein | 11124226 |
| D002738 | Chloroquine | CYP3A4 protein affects the metabolism of Chloroquine | 12920490 |
| D002746 | Chlorpromazine | Chlorpromazine results in decreased activity of CYP3A4 protein | 15135088 |
| D002746 | Chlorpromazine | [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D002746 | Chlorpromazine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine | 23397584 |
| D002746 | Chlorpromazine | CYP3A4 protein affects the methylation of Chlorpromazine | 20615392 |
| D002746 | Chlorpromazine | CYP3A4 protein affects the oxidation of Chlorpromazine | 20615392 |
| D002746 | Chlorpromazine | CYP3A4 protein results in decreased susceptibility to Chlorpromazine | 26477383 |
| D002748 | Chlorpropham | [Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA | 25028461 |
| D004390 | Chlorpyrifos | [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein | 22515965 |
| D004390 | Chlorpyrifos | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| D004390 | Chlorpyrifos | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran] | 15560889 |
| D004390 | Chlorpyrifos | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in decreased activity of CYP3A4 protein | 15560889|1679055 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased activity of CYP3A4 protein | 22310298 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased expression of CYP3A4 mRNA | 16190164|1675708 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased expression of CYP3A4 protein | 15548381|2251596 |
| D004390 | Chlorpyrifos | CYP3A4 protein affects the metabolism of Chlorpyrifos | 16190164|1707935 |
| D004390 | Chlorpyrifos | CYP3A4 results in increased metabolism of Chlorpyrifos | 20709133 |
| D004390 | Chlorpyrifos | [Endosulfan co-treated with Chlorpyrifos co-treated with Atrazine] results in increased expression of CYP3A4 mRNA | 24343343 |
| D004390 | Chlorpyrifos | [Endosulfan co-treated with Chlorpyrifos] results in increased expression of CYP3A4 mRNA | 24343343 |
| C561233 | cholan-2,3,24-tryl-2,3,24-trisulfate | "cholan-2,3,24-tryl-2,3,24-trisulfate results in increased expression of CYP3A4 mRNA" | 21141967 |
| C099828 | cholest-5-ene-3,4-diol | "CYP3A4 protein results in increased chemical synthesis of cholest-5-ene-3,4-diol" | 19954708 |
| C099828 | cholest-5-ene-3,4-diol | "[CYP3A4 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-ene-3,4-diol" | 11514559 |
| D002784 | Cholesterol | Cholesterol promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D002784 | Cholesterol | "[CYP3A4 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-ene-3,4-diol" | 11514559 |
| D002784 | Cholesterol | Cholesterol results in decreased activity of CYP3A4 protein | 18420780 |
| D019826 | Cholic Acid | Cholic Acid metabolite results in decreased activity of CYP3A4 protein | 27871908 |
| D019826 | Cholic Acid | Cholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D019826 | Cholic Acid | Cholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C043561 | chrysin | chrysin binds to and results in decreased activity of CYP3A4 protein | 21053930 |
| C043561 | chrysin | chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | 19766177 |
| D002927 | Cimetidine | Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine] | 18846481 |
| D002927 | Cimetidine | Cimetidine results in decreased activity of CYP3A4 protein | 16041596|1990976 |
| D002927 | Cimetidine | Cimetidine results in decreased expression of CYP3A4 protein | 22733800 |
| D002927 | Cimetidine | [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein | 22733800 |
| D002927 | Cimetidine | styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein] | 19909766 |
| D002927 | Cimetidine | Cimetidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C045316 | cinitapride | CYP3A4 protein results in increased metabolism of cinitapride | 17437965 |
| C029010 | cinnamic acid | cinnamic acid analog results in decreased activity of CYP3A4 protein | 15072549 |
| C002471 | cinobufagin | cinobufagin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| C002471 | cinobufagin | cinobufagin results in increased expression of and results in increased activity of CYP3A4 protein | 22178124 |
| C002471 | cinobufagin | cinobufagin results in increased expression of CYP3A4 mRNA | 22178124 |
| C002471 | cinobufagin | CYP3A4 protein results in increased metabolism of cinobufagin | 22178124 |
| C002471 | cinobufagin | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin] | 22178124 |
| D002939 | Ciprofloxacin | Ciprofloxacin results in decreased activity of CYP3A4 protein | 11145498 |
| D002939 | Ciprofloxacin | Ciprofloxacin inhibits the reaction [CYP3A4 protein results in increased metabolism of Quinidine] | 15869686 |
| D002939 | Ciprofloxacin | Ciprofloxacin results in decreased activity of CYP3A4 protein | 15869686 |
| D020117 | Cisapride | Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D020117 | Cisapride | Cisapride results in decreased activity of CYP3A4 protein | 15306208 |
| D020117 | Cisapride | CYP3A4 protein affects the chemical synthesis of Cisapride metabolite | 11717173 |
| D020117 | Cisapride | CYP3A4 protein affects the metabolism of Cisapride | 11717173 |
| D020117 | Cisapride | Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D020117 | Cisapride | Cisapride results in decreased activity of CYP3A4 protein | 11274899 |
| D020117 | Cisapride | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased degradation of Cisapride] | 9292575 |
| D020117 | Cisapride | CYP3A4 protein results in increased degradation of Cisapride | 9545159 |
| D020117 | Cisapride | CYP3A4 protein results in increased metabolism of Cisapride | 12052668 |
| D015283 | Citalopram | CYP3A4 protein results in decreased methylation of Citalopram analog | 9110356 |
| D015283 | Citalopram | CYP3A4 protein affects the metabolism of Citalopram | 16702909 |
| D015283 | Citalopram | CYP3A4 protein affects the methylation of Citalopram | 15765832 |
| C007076 | citral | citral inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D017291 | Clarithromycin | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D017291 | Clarithromycin | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Disopyramide] | 10234723 |
| D017291 | Clarithromycin | Clarithromycin results in decreased activity of CYP3A4 protein | 16416302|2374874 |
| D017291 | Clarithromycin | Clarithromycin results in decreased expression of CYP3A4 mRNA | 16837568 |
| D017291 | Clarithromycin | [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] | 11408986 |
| D017291 | Clarithromycin | Clarithromycin binds to and results in decreased activity of CYP3A4 protein | 19207666 |
| D017291 | Clarithromycin | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased degradation of Cisapride] | 9292575 |
| D017291 | Clarithromycin | Clarithromycin results in decreased activity of CYP3A4 protein | 10234723|2030530 |
| D002981 | Clindamycin | Clindamycin results in increased expression of and results in increased activity of CYP3A4 protein | 18505790 |
| D002981 | Clindamycin | Clindamycin results in increased expression of CYP3A4 mRNA | 18505790 |
| C012255 | clobazam | CYP3A4 protein results in increased metabolism of clobazam | 28243904 |
| C012255 | clobazam | [CYP3A4 protein results in increased metabolism of clobazam] which results in increased chemical synthesis of N-desmethylclobazam | 28243904 |
| D002990 | Clobetasol | [Clobetasol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D002995 | Clofibric Acid | Clofibric Acid results in increased activity of CYP3A4 protein | 15771232 |
| D002995 | Clofibric Acid | Clofibric Acid results in increased expression of CYP3A4 mRNA | 15771232 |
| D002996 | Clomiphene | [Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D002997 | Clomipramine | CYP3A4 protein results in decreased methylation of Clomipramine | 10353456 |
| C055162 | clopidogrel | CYP3A4 gene polymorphism affects the susceptibility to clopidogrel | 16645157 |
| C055162 | clopidogrel | CYP3A4 protein results in increased degradation of clopidogrel | 22651985 |
| C055162 | clopidogrel | CYP3A4 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite | 19170597 |
| C055162 | clopidogrel | CYP3A4 protein results in increased susceptibility to clopidogrel | 22651985 |
| C055162 | clopidogrel | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of clopidogrel] | 22651985 |
| C055162 | clopidogrel | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to clopidogrel] | 22651985 |
| C055162 | clopidogrel | CYP3A4 protein results in increased metabolism of clopidogrel | 17261397|1844034 |
| D003022 | Clotrimazole | Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D003022 | Clotrimazole | Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] | 17998298 |
| D003022 | Clotrimazole | Clotrimazole results in decreased activity of CYP3A4 protein | 15135088 |
| D003022 | Clotrimazole | Clotrimazole results in increased activity of CYP3A4 protein | 12065438|1497787 |
| D003022 | Clotrimazole | Clotrimazole results in increased expression of CYP3A4 mRNA | 12505310|1267303 |
| D003022 | Clotrimazole | Clotrimazole results in increased expression of CYP3A4 protein | 8632764 |
| D003022 | Clotrimazole | NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA] | 27507784 |
| D003022 | Clotrimazole | Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D003024 | Clozapine | Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21402137 |
| D003024 | Clozapine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine | 23397584 |
| D003024 | Clozapine | CYP3A4 protein affects the metabolism of Clozapine | 15286053 |
| D003024 | Clozapine | CYP3A4 protein results in increased metabolism of Clozapine | 18809730|2732096 |
| D003024 | Clozapine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D003024 | Clozapine | CYP3A4 protein affects the metabolism of Clozapine | 10830154 |
| C079149 | clozapine N-oxide | CYP3A4 protein results in increased abundance of clozapine N-oxide | 27320963 |
| C079149 | clozapine N-oxide | CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide | 18809730 |
| C079149 | clozapine N-oxide | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide] | 18809730 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of CYP3A4 mRNA | 19695866 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of CYP3A4 protein | 19695866 |
| D003061 | Codeine | CYP3A4 protein affects the metabolism of Codeine | 15286053 |
| D003061 | Codeine | CYP3A4 protein results in increased metabolism of Codeine | 16595712 |
| D003061 | Codeine | [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine | 16595712 |
| D009249 | NADP | [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine] | 22390216 |
| D009249 | NADP | [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] | 22390216 |
| D009249 | NADP | CYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] | 22390216 |
| D009249 | NADP | "[CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine" | 20825217 |
| D009249 | NADP | "[[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene" | 21766881 |
| D009249 | NADP | [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal | 21766881 |
| D009249 | NADP | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine | 22390216 |
| D009249 | NADP | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine | 22390216 |
| D009249 | NADP | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 7-hydroxyellipticine | 22390216 |
| D009249 | NADP | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine | 22390216 |
| D009249 | NADP | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine | 22390216 |
| D009249 | NADP | Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein] | 19818743 |
| D009249 | NADP | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | [NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid | 24120545 |
| D009249 | NADP | [NADP co-treated with CYP3A4 protein] results in increased activity of imidacloprid analog | 16153789 |
| D009249 | NADP | [NADP co-treated with CYP3A4 protein] results in increased activity of thiamethoxam | 16153789 |
| D009249 | NADP | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | [retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein | 19818743 |
| D009249 | NADP | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D009249 | NADP | Acetylcysteine affects the reaction [[CYP3A4 protein co-treated with NADP] results in increased metabolism of Erlotinib Hydrochloride] | 21395287 |
| D009249 | NADP | Acetylcysteine affects the reaction [[CYP3A4 protein co-treated with NADP] results in increased metabolism of Isoquinolines] | 21395287 |
| D009249 | NADP | [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of Raloxifene Hydrochloride | 22429462 |
| D009249 | NADP | [CYP3A4 protein co-treated with NADP] results in increased metabolism of Erlotinib Hydrochloride | 21395287 |
| D009249 | NADP | [CYP3A4 protein co-treated with NADP] results in increased metabolism of Isoquinolines | 21395287 |
| D009249 | NADP | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased metabolism of NADP | 16987939 |
| D009249 | NADP | [CYP3A4 protein mutant form co-treated with NADP] results in increased chemical synthesis of 6 beta-hydroxytestosterone | 16987939 |
| D003078 | Colchicine | CYP3A4 protein affects the metabolism of Colchicine | 15914514|1600752 |
| D003345 | Corticosterone | [Corticosterone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | 12851153|1285115 |
| D003345 | Corticosterone | Corticosterone promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 11581012 |
| D003345 | Corticosterone | Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 12072427 |
| D003345 | Corticosterone | Corticosterone results in increased expression of CYP3A4 mRNA | 12072427 |
| D003345 | Corticosterone | Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | 12072427 |
| D003345 | Corticosterone | Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA] | 12072427 |
| D003345 | Corticosterone | Corticosterone results in increased metabolism of CYP3A4 protein | 20032461 |
| C007133 | cortisol succinate | [cortisol succinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4 | 18347083 |
| C059483 | CQA 206-291 | CYP3A4 protein results in increased metabolism of CQA 206-291 | 1346997 |
| C551994 | crizotinib | crizotinib results in increased expression of CYP3A4 mRNA | 23129213 |
| C037886 | cryptotanshinone | cryptotanshinone results in increased expression of CYP3A4 protein | 18805405 |
| C007164 | cumene hydroperoxide | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased chemical synthesis of 6 beta-hydroxytestosterone | 16987939 |
| C007164 | cumene hydroperoxide | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased metabolism of 7-benzyloxyquinoline | 16987939 |
| C007164 | cumene hydroperoxide | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased metabolism of NADP | 16987939 |
| C007164 | cumene hydroperoxide | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased metabolism of Testosterone | 16987939 |
| D003474 | Curcumin | [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA | 20153625 |
| D003474 | Curcumin | Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein] | 17270371 |
| D003474 | Curcumin | Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 17270371|1796552 |
| D003474 | Curcumin | Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D003474 | Curcumin | Curcumin results in decreased expression of CYP3A4 mRNA | 20816778 |
| D003474 | Curcumin | Curcumin results in increased expression of CYP3A4 mRNA | 17210444 |
| D003505 | Cyclodextrins | Cyclodextrins analog results in decreased activity of CYP3A4 protein | 15665498 |
| D003513 | Cycloheximide | Cycloheximide results in decreased expression of CYP3A4 mRNA | 21466820 |
| D003520 | Cyclophosphamide | [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D003520 | Cyclophosphamide | Cyclophosphamide results in increased expression of CYP3A4 mRNA | 18839173 |
| D003520 | Cyclophosphamide | CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] | 16087946 |
| D003520 | Cyclophosphamide | CYP3A4 gene polymorphism affects the susceptibility to Cyclophosphamide | 16087946 |
| D003520 | Cyclophosphamide | CYP3A4 protein affects the metabolism of Cyclophosphamide | 16087946 |
| D003520 | Cyclophosphamide | CYP3A4 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide | 25860621 |
| D003520 | Cyclophosphamide | CYP3A4 protein results in increased metabolism of Cyclophosphamide | 11377097 |
| D003520 | Cyclophosphamide | CYP3A4 protein results in increased susceptibility to Cyclophosphamide | 26718876 |
| D003520 | Cyclophosphamide | Cyclophosphamide results in decreased activity of CYP3A4 protein | 18420780 |
| D016572 | Cyclosporine | Cyclosporine affects the expression of CYP3A4 mRNA | 24973091 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| D016572 | Cyclosporine | Cyclosporine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of CYP3A4 mRNA | 20106945|2798913 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of CYP3A4 mRNA | 12673034 |
| D016572 | Cyclosporine | CYP3A4 protein affects the metabolism of Cyclosporine | 15286053|1545095 |
| D016572 | Cyclosporine | CYP3A4 protein results in increased metabolism of Cyclosporine | 20599501 |
| D016572 | Cyclosporine | Cyclosporine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of CYP3A4 mRNA | 19224547 |
| C052570 | cyfluthrin | cyfluthrin results in increased expression of CYP3A4 mRNA | 19249324 |
| C037304 | cyhalothrin | cyhalothrin results in decreased activity of CYP3A4 protein | 20183062 |
| C037304 | cyhalothrin | cyhalothrin results in increased activity of CYP3A4 protein | 22310298 |
| C037304 | cyhalothrin | cyhalothrin results in increased expression of CYP3A4 mRNA | 19249324|2231029 |
| C037304 | cyhalothrin | cyhalothrin results in increased expression of CYP3A4 protein | 19249324 |
| C037304 | cyhalothrin | [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA | 25028461 |
| C017160 | cypermethrin | cypermethrin results in decreased activity of CYP3A4 protein | 18420780|2263405 |
| C017160 | cypermethrin | cypermethrin results in increased activity of CYP3A4 protein | 22310298 |
| C017160 | cypermethrin | cypermethrin results in increased expression of CYP3A4 mRNA | 22310298 |
| C017160 | cypermethrin | cypermethrin results in increased expression of CYP3A4 protein | 15548381 |
| C093628 | cyproconazole | [azoxystrobin co-treated with cyproconazole] results in increased expression of CYP3A4 protein | 29294346 |
| C093628 | cyproconazole | [cyproconazole co-treated with azoxystrobin] results in increased expression of CYP3A4 mRNA | 29294346 |
| C093628 | cyproconazole | cyproconazole results in increased expression of CYP3A4 protein | 29294346 |
| C108338 | cyprodinil | [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA | 25028461 |
| D017373 | Cyproterone Acetate | Cyproterone Acetate results in increased expression of CYP3A4 mRNA | 12505310 |
| D003609 | Dactinomycin | "Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]" | 15795092 |
| D003609 | Dactinomycin | Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A4 mRNA] | 24819614 |
| C004742 | daidzein | daidzein results in decreased activity of CYP3A4 protein | 18420780 |
| D003622 | Dapsone | CYP3A4 protein affects the metabolism of Dapsone | 12920490|1532758 |
| D003622 | Dapsone | [SOD2 co-treated with CYP3A4] affects the susceptibility to Dapsone | 19501153 |
| C035934 | dauricine | CYP3A4 protein results in increased glutathionylation of dauricine | 19358519 |
| C035934 | dauricine | [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine | 19358519 |
| C035934 | dauricine | [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of quinone methide | 19358519 |
| C035934 | dauricine | CYP3A4 protein results in increased oxidation of and results in increased activity of dauricine | 19358519 |
| C035934 | dauricine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine] | 19358519 |
| D003634 | DDT | [DDT co-treated with Dieldrin] results in increased expression of CYP3A4 mRNA | 25028461 |
| D003634 | DDT | DDT results in increased expression of CYP3A4 mRNA | 17035600|2068633 |
| D003634 | DDT | DDT results in increased expression of CYP3A4 protein | 15548381 |
| C010902 | decabromobiphenyl ether | decabromobiphenyl ether results in increased expression of CYP3A4 mRNA | 19270788 |
| C017180 | decamethrin | decamethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| C017180 | decamethrin | decamethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| C017180 | decamethrin | decamethrin results in decreased activity of CYP3A4 protein | 16790556 |
| C017180 | decamethrin | decamethrin results in increased activity of CYP3A4 protein | 22310298 |
| C017180 | decamethrin | decamethrin results in increased expression of CYP3A4 mRNA | 19249324|1932676 |
| C064445 | dechloroethylcyclophosphamide | CYP3A4 protein affects the chemical synthesis of dechloroethylcyclophosphamide | 15875221 |
| D003671 | DEET | CYP3A4 protein results in increased metabolism of DEET | 11854147 |
| D003671 | DEET | DEET results in increased expression of CYP3A4 mRNA | 19326769|2709163 |
| D003671 | DEET | [fipronil co-treated with DEET] results in increased expression of CYP3A4 mRNA | 27091632 |
| D003676 | Deferoxamine | Deferoxamine results in decreased expression of CYP3A4 mRNA | 19695866 |
| D003676 | Deferoxamine | Deferoxamine results in decreased expression of CYP3A4 protein | 19695866 |
| D003687 | Dehydroepiandrosterone | CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone | 15845858 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D019314 | Dehydroepiandrosterone Sulfate | CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate | 2271712 |
| D020008 | Delavirdine | Delavirdine results in decreased activity of CYP3A4 protein | 11959068|2111246 |
| C052300 | deltanit | deltanit results in increased activity of CYP3A4 protein | 22310298 |
| C052300 | deltanit | deltanit results in increased expression of CYP3A4 mRNA | 22310298 |
| D003840 | Deoxycholic Acid | CYP3A4 protein affects the metabolism of Deoxycholic Acid | 15708356 |
| D003840 | Deoxycholic Acid | Deoxycholic Acid metabolite results in decreased activity of CYP3A4 protein | 27871908 |
| D003840 | Deoxycholic Acid | Deoxycholic Acid metabolite results in increased expression of CYP3A4 mRNA | 27871908 |
| C528427 | deoxyelephantopin | deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 23876819 |
| C528427 | deoxyelephantopin | deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 23876819 |
| C528427 | deoxyelephantopin | deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine] | 23876819 |
| C528427 | deoxyelephantopin | deoxyelephantopin results in decreased activity of CYP3A4 protein | 23876819 |
| C528427 | deoxyelephantopin | deoxyelephantopin results in increased expression of and results in increased activity of CYP3A4 protein | 23876819 |
| C528427 | deoxyelephantopin | deoxyelephantopin results in increased expression of CYP3A4 mRNA | 23876819 |
| D003849 | Deoxyguanosine | CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] | 21907773 |
| D003849 | Deoxyguanosine | CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] | 21907773 |
| C007262 | deoxynivalenol | deoxynivalenol affects the expression of CYP3A4 mRNA | 28865950 |
| C007262 | deoxynivalenol | [deoxynivalenol co-treated with Zearalenone] affects the expression of CYP3A4 mRNA | 28865950 |
| C007262 | deoxynivalenol | [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP3A4 protein | 28865950 |
| C007262 | deoxynivalenol | [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 mRNA | 28935499 |
| C007262 | deoxynivalenol | [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 protein | 28935499 |
| C036116 | desethylamiodarone | CYP3A4 protein results in increased chemical synthesis of desethylamiodarone | 8445979 |
| C036116 | desethylamiodarone | CYP3A4 protein results in increased metabolism of desethylamiodarone | 22785256 |
| C036116 | desethylamiodarone | [desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA | 22785256 |
| C036116 | desethylamiodarone | [desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein | 22785256 |
| C036116 | desethylamiodarone | [desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA | 22785256 |
| C036116 | desethylamiodarone | [desethylamiodarone co-treated with CYP3A4 protein] results in increased secretion of CXCL8 protein | 22785256 |
| C036116 | desethylamiodarone | [desethylamiodarone co-treated with CYP3A4 protein] results in increased secretion of TNF protein | 22785256 |
| C036116 | desethylamiodarone | Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA] | 22785256 |
| C036116 | desethylamiodarone | Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA] | 22785256 |
| C047386 | desethylamodiaquine | CYP3A4 protein results in increased metabolism of desethylamodiaquine | 28478157 |
| C007278 | desethylchloroquine | desethylchloroquine results in decreased activity of CYP3A4 protein | 11124226 |
| D003891 | Desipramine | CYP3A4 protein results in increased susceptibility to Desipramine | 21540358 |
| D003891 | Desipramine | Desipramine results in decreased activity of CYP3A4 protein | 15135088 |
| D003907 | Dexamethasone | CYP3A4 promoter mutant form inhibits the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA] | 12505310|1250531 |
| D003907 | Dexamethasone | CYP3A4 protein affects the metabolism of Dexamethasone | 8114683 |
| D003907 | Dexamethasone | [Dexamethasone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | 12851153|1285115 |
| D003907 | Dexamethasone | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased activity of CYP3A4 protein | 18332045 |
| D003907 | Dexamethasone | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased expression of CYP3A4 protein | 18332045 |
| D003907 | Dexamethasone | [Dexamethasone co-treated with mono-(2-ethylhexyl)phthalate] results in increased activity of CYP3A4 protein | 18332045 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| D003907 | Dexamethasone | Dexamethasone promotes the reaction [fenvalerate results in increased expression of CYP3A4 mRNA] | 20599767 |
| D003907 | Dexamethasone | Dexamethasone promotes the reaction [Rifampin results in increased activity of CYP3A4 protein] | 18332045 |
| D003907 | Dexamethasone | Dexamethasone results in increased activity of CYP3A4 protein | 10923861|1140994 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of CYP3A4 mRNA | 10219967|1250531 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of CYP3A4 protein | 10640517|1269535 |
| D003907 | Dexamethasone | [Dexamethasone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| D003907 | Dexamethasone | fenvalerate promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA] | 20599767 |
| D003907 | Dexamethasone | Mifepristone inhibits the reaction [NR3C1 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA]] | 10219967 |
| D003907 | Dexamethasone | NR3C1 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA] | 10219967 |
| D003907 | Dexamethasone | Dexamethasone results in increased activity of CYP3A4 protein | 20361990 |
| D003907 | Dexamethasone | NR1I2 affects the reaction [Dexamethasone results in increased activity of CYP3A4 protein] | 20361990 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of CYP3A4 mRNA | 20035846 |
| D003907 | Dexamethasone | Dexamethasone promotes the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 21964476 |
| D003907 | Dexamethasone | "Dexamethasone promotes the reaction [CYP3A4 protein results in increased susceptibility to 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione]" | 21964476 |
| D003907 | Dexamethasone | Dexamethasone promotes the reaction [[Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA] | 18332045 |
| D003907 | Dexamethasone | Dexamethasone promotes the reaction [[mono-(2-ethylhexyl)phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA] | 18332045 |
| D003907 | Dexamethasone | Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [[Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| D003907 | Dexamethasone | Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [[mono-(2-ethylhexyl)phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| D003907 | Dexamethasone | NR3C1 mRNA affects the reaction [Dexamethasone promotes the reaction [[Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| C032201 | dexamethasone 21-tributylacetate | dexamethasone 21-tributylacetate results in increased activity of CYP3A4 protein | 12065438 |
| D003917 | Dextrorphan | CYP3A4 protein affects the metabolism of Dextrorphan | 15988119 |
| D003917 | Dextrorphan | CYP3A4 protein results in increased metabolism of Dextrorphan | 21606622 |
| D003917 | Dextrorphan | [CYP3A4 protein results in increased metabolism of Dextrorphan] which results in increased chemical synthesis of norlevorphanol | 21606622 |
| D036381 | Diarylheptanoids | Diarylheptanoids results in decreased activity of CYP3A4 protein | 23850985 |
| D036381 | Diarylheptanoids | Diarylheptanoids results in increased expression of CYP3A4 mRNA | 23850985 |
| D003975 | Diazepam | CYP3A4 protein affects the metabolism of Diazepam | 16048486 |
| D003975 | Diazepam | CYP3A4 protein results in increased metabolism of Diazepam | 18846481 |
| D003975 | Diazepam | Diazepam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D003975 | Diazepam | Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21402137 |
| D003975 | Diazepam | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D003975 | Diazepam | Diazepam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D003976 | Diazinon | CYP3A4 protein affects the metabolism of Diazinon | 15764407 |
| D003976 | Diazinon | CYP3A4 protein results in decreased sulfation of and results in increased activity of Diazinon | 15764407 |
| D003976 | Diazinon | CYP3A4 protein results in increased metabolism of and results in increased activity of Diazinon | 11708902 |
| D003976 | Diazinon | Diazinon results in increased expression of CYP3A4 mRNA | 16757081 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21742782 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of CYP3A4 protein | 26721606 |
| D002945 | Cisplatin | Cisplatin results in increased expression of CYP3A4 mRNA | 15650019 |
| D002945 | Cisplatin | Cisplatin results in increased expression of CYP3A4 protein | 15650019 |
| D002945 | Cisplatin | CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] | 16087946 |
| D002945 | Cisplatin | [Proadifen co-treated with Cisplatin] results in decreased expression of CYP3A4 protein | 26721606 |
| D003632 | Dichlorodiphenyldichloroethane | Dichlorodiphenyldichloroethane results in increased expression of CYP3A4 mRNA | 20686338 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene results in increased expression of CYP3A4 mRNA | 20686338 |
| D004004 | Dichlororibofuranosylbenzimidazole | Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] | 17003103 |
| D004004 | Dichlororibofuranosylbenzimidazole | Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 17003103 |
| D004008 | Diclofenac | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac | 23397584 |
| D004008 | Diclofenac | [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac | 28762043 |
| D004008 | Diclofenac | [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac | 28762043 |
| D004008 | Diclofenac | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac | 24246759 |
| D004008 | Diclofenac | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac | 24246759 |
| D004008 | Diclofenac | [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac | 24246759 |
| D004008 | Diclofenac | CYP3A4 protein results in increased metabolism of Diclofenac | 24104198 |
| D004008 | Diclofenac | CYP3A4 protein results in increased susceptibility to Diclofenac | 28762043 |
| D004008 | Diclofenac | Diclofenac metabolite results in decreased activity of CYP3A4 protein | 28960974 |
| D004008 | Diclofenac | Diclofenac results in decreased activity of CYP3A4 protein | 15135088 |
| D004008 | Diclofenac | Diclofenac results in increased expression of CYP3A4 mRNA | 19022234 |
| D004008 | Diclofenac | Diclofenac results in decreased activity of CYP3A4 protein | 18420780 |
| D004008 | Diclofenac | CYP3A4 protein results in increased hydroxylation of Diclofenac | 27130197 |
| D004009 | Dicloxacillin | Dicloxacillin results in increased expression of and results in increased activity of CYP3A4 protein | 18505790 |
| D004009 | Dicloxacillin | Dicloxacillin results in increased expression of CYP3A4 mRNA | 18505790 |
| C036042 | dicyclohexyl phthalate | dicyclohexyl phthalate results in increased expression of CYP3A4 mRNA | 26924002 |
| D004026 | Dieldrin | [DDT co-treated with Dieldrin] results in increased expression of CYP3A4 mRNA | 25028461 |
| D004026 | Dieldrin | Dieldrin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 12417264 |
| D004026 | Dieldrin | Dieldrin results in increased expression of CYP3A4 protein | 15548381 |
| D004051 | Diethylhexyl Phthalate | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased activity of CYP3A4 protein | 18332045 |
| D004051 | Diethylhexyl Phthalate | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased expression of CYP3A4 protein | 18332045 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 11581012 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in increased activity of CYP3A4 protein | 21742782 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in increased expression of CYP3A4 protein | 21227907 |
| D004051 | Diethylhexyl Phthalate | [Diethylhexyl Phthalate co-treated with Linuron] results in increased expression of CYP3A4 mRNA | 22277248 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in increased expression of CYP3A4 mRNA | 22277248 |
| D004051 | Diethylhexyl Phthalate | Dexamethasone promotes the reaction [[Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA] | 18332045 |
| D004051 | Diethylhexyl Phthalate | [Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 18332045 |
| D004051 | Diethylhexyl Phthalate | Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [[Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| D004051 | Diethylhexyl Phthalate | NR3C1 mRNA affects the reaction [Dexamethasone promotes the reaction [[Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased activity of CYP3A4 protein | 23384967 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of CYP3A4 mRNA | 21924250|2338496 |
| C039060 | dihydroartemisinin | dihydroartemisinin results in decreased activity of CYP3A4 protein | 11124226 |
| D004087 | Dihydroergotamine | Dihydroergotamine results in decreased activity of CYP3A4 protein | 18420780 |
| D002117 | Calcitriol | Calcitriol results in increased expression of CYP3A4 mRNA | 15992766 |
| D002117 | Calcitriol | 2-acetyltributylcitrate promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 21742782 |
| D002117 | Calcitriol | [Calcitriol binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA | 15489543|1557859 |
| D002117 | Calcitriol | Calcitriol promotes the reaction [2-acetyltributylcitrate results in increased activity of CYP3A4 protein] | 21742782 |
| D002117 | Calcitriol | Calcitriol promotes the reaction [2-acetyltributylcitrate results in increased expression of CYP3A4 mRNA] | 21742782 |
| D002117 | Calcitriol | Calcitriol promotes the reaction [Rifampin results in increased activity of CYP3A4 protein] | 21742782 |
| D002117 | Calcitriol | Calcitriol promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 21742782 |
| D002117 | Calcitriol | Calcitriol results in increased activity of CYP3A4 protein | 19766177 |
| D002117 | Calcitriol | Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein | 17270371 |
| D002117 | Calcitriol | Calcitriol results in increased expression of CYP3A4 mRNA | 11723248|1599276 |
| D002117 | Calcitriol | Calcitriol results in increased expression of CYP3A4 protein | 11723248|2636675 |
| D002117 | Calcitriol | [Calcitriol results in increased expression of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 22687401 |
| D002117 | Calcitriol | chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | 19766177 |
| D002117 | Calcitriol | Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein] | 17270371 |
| D002117 | Calcitriol | Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 17270371|1796552 |
| D002117 | Calcitriol | Genistein inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | 19766177 |
| D002117 | Calcitriol | pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 17965521 |
| D002117 | Calcitriol | Quercetin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | 19766177 |
| D002117 | Calcitriol | Rifampin promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 21742782 |
| D002117 | Calcitriol | Staurosporine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 17965521 |
| D002117 | Calcitriol | VDR protein affects the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 21742782 |
| D002117 | Calcitriol | Calcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP3A4 promoter] | 15992766 |
| C012125 | diisononyl phthalate | diisononyl phthalate results in increased expression of CYP3A4 protein | 21227907 |
| D004110 | Diltiazem | CYP3A4 protein affects the metabolism of Diltiazem | 15286053 |
| D004110 | Diltiazem | CYP3A4 protein results in decreased methylation of Diltiazem | 15499178 |
| D004110 | Diltiazem | Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 22652334 |
| D004110 | Diltiazem | Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 22652334 |
| D004110 | Diltiazem | Diltiazem inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004110 | Diltiazem | Diltiazem results in decreased activity of CYP3A4 protein | 22652334 |
| D004110 | Diltiazem | potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]] | 22652334 |
| D004110 | Diltiazem | potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]] | 22652334 |
| D004110 | Diltiazem | potassium ferricyanide inhibits the reaction [Diltiazem results in decreased activity of CYP3A4 protein] | 22652334 |
| D004110 | Diltiazem | potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]] | 22652334 |
| D004110 | Diltiazem | potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]] | 22652334 |
| D004110 | Diltiazem | Diltiazem inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004110 | Diltiazem | Diltiazem results in decreased activity of CYP3A4 protein | 21112467|9545159 |
| C012621 | dimemorfan | CYP3A4 protein results in increased oxidation of dimemorfan | 19593786 |
| C012621 | dimemorfan | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan] | 19593786 |
| C066888 | dimethocaine | CYP3A4 protein results in decreased ethylation of dimethocaine | 24309420 |
| C066888 | dimethocaine | CYP3A4 protein results in increased hydroxylation of dimethocaine | 24309420 |
| C472511 | dimethylarsinous acid | dimethylarsinous acid results in increased activity of CYP3A4 protein | 19084030 |
| C472511 | dimethylarsinous acid | dimethylarsinous acid results in increased expression of CYP3A4 mRNA | 19084030 |
| C472511 | dimethylarsinous acid | dimethylarsinous acid results in increased expression of CYP3A4 protein | 19084030 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "CYP3A4 protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene" | 20507880 |
| C024629 | dimethyl phthalate | dimethyl phthalate affects the expression of CYP3A4 mRNA | 26924002 |
| D004121 | Dimethyl Sulfoxide | [cortisol succinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4 | 18347083 |
| D004121 | Dimethyl Sulfoxide | Dimethyl Sulfoxide affects the expression of CYP3A4 mRNA | 12843640 |
| C039602 | diosmetin | diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 18191104 |
| C039602 | diosmetin | diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 18191104 |
| D004147 | Dioxins | Dioxins results in increased expression of CYP3A4 mRNA | 15977188 |
| D004147 | Dioxins | Dioxins results in increased expression of CYP3A4 protein | 15977188 |
| D004159 | Diphenylamine | "[Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA" | 25028461 |
| C007517 | diphenyleneiodonium | diphenyleneiodonium results in decreased activity of CYP3A4 protein | 26880746 |
| C007517 | diphenyleneiodonium | diphenyleneiodonium results in decreased activity of CYP3A4 protein | 12388057 |
| D004206 | Disopyramide | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Disopyramide] | 10234723 |
| D004206 | Disopyramide | CYP3A4 protein results in increased metabolism of Disopyramide | 10901704 |
| D004206 | Disopyramide | CYP3A4 protein results in increased metabolism of Disopyramide | 10234723 |
| D004221 | Disulfiram | CYP3A4 protein results in increased susceptibility to Disulfiram | 21540358 |
| C071869 | dithiopyr | dithiopyr results in increased expression of CYP3A4 mRNA | 17293382 |
| D004237 | Diuron | Diuron results in increased expression of CYP3A4 mRNA | 22310298 |
| C067311 | docetaxel | CYP3A4 mRNA results in increased susceptibility to docetaxel | 15239142 |
| C067311 | docetaxel | docetaxel results in increased expression of CYP3A4 mRNA | 18839173 |
| D004281 | Docosahexaenoic Acids | Docosahexaenoic Acids results in decreased activity of CYP3A4 protein | 16978661 |
| D004294 | Domperidone | CYP3A4 protein results in increased hydroxylation of and results in decreased alkylation of Domperidone | 15327587 |
| D004298 | Dopamine | Dopamine results in decreased activity of CYP3A4 protein | 18420780 |
| C038345 | droloxifene | droloxifene results in decreased activity of CYP3A4 protein | 12419016 |
| D004365 | Drugs, Chinese Herbal | "[Drugs, Chinese Herbal results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA" | 21524698 |
| D004365 | Drugs, Chinese Herbal | "Drugs, Chinese Herbal results in increased expression of CYP3A4 mRNA" | 12695340|1626713 |
| D004464 | Econazole | Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] | 17998298 |
| D004464 | Econazole | Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 17998298 |
| D004464 | Econazole | Econazole results in decreased activity of CYP3A4 protein | 15135088 |
| D004464 | Econazole | Econazole results in increased expression of CYP3A4 mRNA | 17998298 |
| C098320 | efavirenz | efavirenz results in decreased activity of CYP3A4 protein | 15980690 |
| C098320 | efavirenz | efavirenz results in increased activity of CYP3A4 protein | 15980690 |
| C098320 | efavirenz | efavirenz results in increased expression of CYP3A4 mRNA | 16837568 |
| C098320 | efavirenz | CYP3A4 protein results in increased metabolism of efavirenz | 16625385 |
| D015118 | Eicosapentaenoic Acid | Eicosapentaenoic Acid results in decreased activity of CYP3A4 protein | 16978661 |
| C547512 | eldecalcitol | CYP3A4 protein results in increased metabolism of eldecalcitol | 26038696 |
| C547512 | eldecalcitol | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol] | 26038696 |
| C034192 | ellipticine | [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine | 22390216 |
| C034192 | ellipticine | CYP3A4 protein results in increased metabolism of ellipticine | 22917556 |
| C547424 | EMD 392949 | EMD 392949 results in increased expression of CYP3A4 mRNA | 20035846 |
| D004642 | Emodin | [CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite | 27989148 |
| D004642 | Emodin | CYP3A4 protein results in increased oxidation of Emodin | 27989148 |
| D004642 | Emodin | Emodin results in decreased activity of CYP3A4 protein | 22813711 |
| D004656 | Enalapril | Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004656 | Enalapril | Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004726 | Endosulfan | [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein | 22515965 |
| D004726 | Endosulfan | CYP3A4 protein affects the metabolism of Endosulfan | 16581944|1685505 |
| D004726 | Endosulfan | CYP3A4 protein results in increased susceptibility to Endosulfan | 20507880 |
| D004726 | Endosulfan | [Endosulfan co-treated with Atrazine] results in increased expression of CYP3A4 mRNA | 24343343 |
| D004726 | Endosulfan | [Endosulfan co-treated with Chlorpyrifos co-treated with Atrazine] results in increased expression of CYP3A4 mRNA | 24343343 |
| D004726 | Endosulfan | [Endosulfan co-treated with Chlorpyrifos] results in increased expression of CYP3A4 mRNA | 24343343 |
| D004726 | Endosulfan | [Endosulfan co-treated with Methoxychlor] results in increased activity of CYP3A4 protein | 24832206 |
| D004726 | Endosulfan | [Endosulfan co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 20361990 |
| D004726 | Endosulfan | Endosulfan promotes the reaction [Methoxychlor results in increased expression of CYP3A4 mRNA] | 24832206 |
| D004726 | Endosulfan | Endosulfan promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 12417264 |
| D004726 | Endosulfan | Endosulfan results in decreased activity of CYP3A4 protein | 24832206 |
| D004726 | Endosulfan | Endosulfan results in increased expression of CYP3A4 mRNA | 12417264|2251596 |
| D004726 | Endosulfan | Endosulfan results in increased expression of CYP3A4 protein | 15548381|2036199 |
| D004726 | Endosulfan | ESR1 mRNA promotes the reaction [Endosulfan results in increased expression of CYP3A4 mRNA] | 28673560 |
| D004726 | Endosulfan | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan] | 16855053 |
| D004726 | Endosulfan | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan] | 20507880 |
| D004726 | Endosulfan | Methoxychlor promotes the reaction [Endosulfan results in increased expression of CYP3A4 mRNA] | 24832206 |
| D004726 | Endosulfan | Endosulfan results in increased activity of CYP3A4 protein | 20361990 |
| D004726 | Endosulfan | Endosulfan results in increased expression of CYP3A4 protein | 20361990 |
| D004726 | Endosulfan | NR1I2 affects the reaction [Endosulfan results in increased activity of CYP3A4 protein] | 20361990 |
| D004726 | Endosulfan | NR1I2 affects the reaction [Endosulfan results in increased expression of CYP3A4 protein] | 20361990 |
| C544689 | endosulfan sulfate | [endosulfan sulfate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 20361990 |
| D004732 | Endrin | Endrin results in increased expression of CYP3A4 protein | 15548381 |
| C017435 | enilconazole | [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA | 25028461 |
| C017435 | enilconazole | enilconazole results in decreased activity of CYP3A4 protein | 21762035 |
| C045651 | epigallocatechin gallate | [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CYP3A4 mRNA | 25922640 |
| C109476 | epoxiconazole | epoxiconazole results in increased expression of CYP3A4 mRNA | 29294346 |
| C109476 | epoxiconazole | epoxiconazole results in increased expression of CYP3A4 protein | 29294346 |
| C109476 | epoxiconazole | [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 mRNA | 29294346 |
| C109476 | epoxiconazole | [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 protein | 29294346 |
| C091891 | epsilon-viniferin | epsilon-viniferin results in decreased activity of CYP3A4 protein | 12818727 |
| D000069347 | Erlotinib Hydrochloride | Erlotinib Hydrochloride results in decreased activity of CYP3A4 protein | 18839173 |
| D000069347 | Erlotinib Hydrochloride | Erlotinib Hydrochloride results in increased expression of CYP3A4 mRNA | 18839173 |
| D000069347 | Erlotinib Hydrochloride | Acetylcysteine affects the reaction [[CYP3A4 protein co-treated with NADP] results in increased metabolism of Erlotinib Hydrochloride] | 21395287 |
| D000069347 | Erlotinib Hydrochloride | [CYP3A4 protein co-treated with NADP] results in increased metabolism of Erlotinib Hydrochloride | 21395287 |
| D004917 | Erythromycin | CYP3A4 protein affects the metabolism of Erythromycin | 8114683 |
| D004917 | Erythromycin | CYP3A4 protein results in decreased methylation of Erythromycin | 15383492|2271712 |
| D004917 | Erythromycin | CYP3A4 protein results in increased metabolism of Erythromycin | 21466820 |
| D004917 | Erythromycin | Erythromycin inhibits the reaction [CYP3A4 protein affects the metabolism of brotizolam] | 16042670 |
| D004917 | Erythromycin | Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| D004917 | Erythromycin | Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| D004917 | Erythromycin | Erythromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D004917 | Erythromycin | Erythromycin inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004917 | Erythromycin | Erythromycin results in decreased activity of CYP3A4 protein | 15466163|1584568 |
| D004917 | Erythromycin | Erythromycin results in increased expression of CYP3A4 mRNA | 18505790 |
| D004917 | Erythromycin | Erythromycin results in increased expression of CYP3A4 protein | 18505790 |
| D004917 | Erythromycin | IFNA protein inhibits the reaction [CYP3A4 protein results in increased metabolism of Erythromycin] | 21466820 |
| D004917 | Erythromycin | Erythromycin results in decreased activity of CYP3A4 protein | 18420780 |
| D004917 | Erythromycin | Erythromycin inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004917 | Erythromycin | Erythromycin results in decreased activity of CYP3A4 protein | 11724091|2111246 |
| D004923 | Erythrosine | Erythrosine results in decreased activity of CYP3A4 protein | 20041016 |
| D004949 | Estazolam | CYP3A4 protein results in increased hydroxylation of Estazolam | 16012077 |
| C025004 | estradiol-17 beta-3-methyl ether | estradiol-17 beta-3-methyl ether binds to CYP3A4 protein | 9047321 |
| D004970 | Estrone | CYP3A4 protein binds to Estrone | 27966929 |
| D004970 | Estrone | CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] | 21907773 |
| D004970 | Estrone | Estrone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004970 | Estrone | Estrone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D000431 | Ethanol | Ethanol results in increased expression of CYP3A4 mRNA | 28062356 |
| D004997 | Ethinyl Estradiol | [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D004997 | Ethinyl Estradiol | CYP3A4 protein affects the hydroxylation of Ethinyl Estradiol | 2271712 |
| D004997 | Ethinyl Estradiol | CYP3A4 protein affects the metabolism of Ethinyl Estradiol | 15286053 |
| D004997 | Ethinyl Estradiol | CYP3A4 protein results in increased hydroxylation of Ethinyl Estradiol | 15304426|1555423 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to and results in decreased activity of CYP3A4 protein | 11907170 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004997 | Ethinyl Estradiol | [Phenobarbital results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D004997 | Ethinyl Estradiol | [pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D004997 | Ethinyl Estradiol | [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D004997 | Ethinyl Estradiol | Testosterone inhibits the reaction [Ethinyl Estradiol results in decreased activity of CYP3A4 protein] | 11907170 |
| D004997 | Ethinyl Estradiol | [troglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D004997 | Ethinyl Estradiol | CYP3A4 protein affects the metabolism of Ethinyl Estradiol | 17284510 |
| C100038 | ethion | [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA | 25028461 |
| C000611514 | ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate | "ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in increased expression of CYP3A4 mRNA" | 28289823 |
| C000611514 | ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate | "NR1I2 mRNA promotes the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in increased expression of CYP3A4 mRNA]" | 28289823 |
| C045989 | eticlopride | [eticlopride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| C044815 | etonogestrel | CYP3A4 protein affects the metabolism of etonogestrel | 15963096 |
| D005047 | Etoposide | Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| D005047 | Etoposide | CYP3A4 gene polymorphism affects the susceptibility to Etoposide | 12969965 |
| D005047 | Etoposide | CYP3A4 protein affects the susceptibility to Etoposide | 17279585 |
| D005047 | Etoposide | CYP3A4 protein results in decreased methylation of Etoposide | 8114683 |
| D005047 | Etoposide | Dexamethasone inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| D005047 | Etoposide | Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| D005047 | Etoposide | [Etoposide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D005047 | Etoposide | Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| C422649 | etoricoxib | CYP3A4 protein results in increased metabolism of etoricoxib | 18084859 |
| C508136 | etoxazole | etoxazole results in increased expression of CYP3A4 mRNA | 17293382 |
| C010087 | eucalyptol | CYP3A4 protein results in increased hydroxylation of eucalyptol | 15715982 |
| C010087 | eucalyptol | eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| C103110 | eupatorin | eupatorin results in decreased activity of CYP3A4 protein | 21276781 |
| D015025 | Zearalenone | [deoxynivalenol co-treated with Zearalenone] affects the expression of CYP3A4 mRNA | 28865950 |
| D015025 | Zearalenone | [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP3A4 protein | 28865950 |
| D015025 | Zearalenone | [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 mRNA | 28935499 |
| D015025 | Zearalenone | [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 protein | 28935499 |
| D015025 | Zearalenone | Zearalenone results in increased expression of CYP3A4 mRNA | 15569515|2886595 |
| D015025 | Zearalenone | Zearalenone results in increased expression of CYP3A4 protein | 28865950 |
| C047360 | felbamate | felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] | 12606595 |
| D015736 | Felodipine | CYP3A4 protein results in increased metabolism of Felodipine | 23876819 |
| D015736 | Felodipine | deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine] | 23876819 |
| D015736 | Felodipine | Felodipine results in increased expression of and results in decreased activity of CYP3A4 protein | 27732883 |
| D015736 | Felodipine | Felodipine results in increased expression of CYP3A4 mRNA | 27732883 |
| D015736 | Felodipine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine] | 23876819 |
| D005278 | Fenitrothion | Fenitrothion results in decreased activity of CYP3A4 protein | 20183062 |
| D005278 | Fenitrothion | Fenitrothion results in increased activity of CYP3A4 protein | 22310298 |
| D005278 | Fenitrothion | Fenitrothion results in increased expression of CYP3A4 mRNA | 17293382|2231029 |
| D005278 | Fenitrothion | "[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA" | 25028461 |
| C006012 | fenofibric acid | fenofibric acid results in increased activity of CYP3A4 protein | 15771232 |
| C006012 | fenofibric acid | fenofibric acid results in increased expression of CYP3A4 mRNA | 15771232 |
| C026013 | fenproporex | CYP3A4 protein results in decreased alkylation of fenproporex | 15294457 |
| D005283 | Fentanyl | CYP3A4 protein results in increased metabolism of Fentanyl | 11811955 |
| D005284 | Fenthion | CYP3A4 protein affects the metabolism of Fenthion | 17110060 |
| C017690 | fenvalerate | Dexamethasone promotes the reaction [fenvalerate results in increased expression of CYP3A4 mRNA] | 20599767 |
| C017690 | fenvalerate | fenvalerate promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA] | 20599767 |
| C017690 | fenvalerate | fenvalerate results in decreased activity of CYP3A4 protein | 22634058 |
| C017690 | fenvalerate | fenvalerate results in increased activity of CYP3A4 protein | 22310298 |
| C017690 | fenvalerate | fenvalerate results in increased expression of CYP3A4 mRNA | 19249324|2059976 |
| C017690 | fenvalerate | fenvalerate results in increased expression of CYP3A4 protein | 15548381 |
| C025314 | ferric citrate | Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA] | 24025710 |
| C025314 | ferric citrate | Alcohols promotes the reaction [ferric citrate results in increased expression of CYP3A4 protein] | 24025710 |
| C025314 | ferric citrate | ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP3A4 mRNA] | 24025710 |
| C025314 | ferric citrate | ferric citrate promotes the reaction [Alcohols results in increased expression of CYP3A4 protein] | 24025710 |
| C025314 | ferric citrate | ferric citrate results in increased expression of CYP3A4 mRNA | 24025710 |
| C025314 | ferric citrate | ferric citrate results in increased expression of CYP3A4 protein | 24025710 |
| D058607 | Fibric Acids | CYP3A4 protein results in increased metabolism of Fibric Acids | 9515185 |
| C082360 | fipronil | [fipronil co-treated with DEET] results in increased expression of CYP3A4 mRNA | 27091632 |
| C082360 | fipronil | fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 17084830 |
| C082360 | fipronil | fipronil results in increased expression of and results in increased activity of CYP3A4 protein | 17084830 |
| C082360 | fipronil | fipronil results in increased expression of CYP3A4 mRNA | 17084830|2709163 |
| D005411 | Flame Retardants | CYP3A4 protein results in increased metabolism of Flame Retardants | 22417763 |
| C028610 | flavanone | flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C028610 | flavanone | flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C028610 | flavanone | flavanone results in decreased activity of CYP3A4 protein | 21053930 |
| C043562 | flavone | flavone binds to and results in decreased activity of CYP3A4 protein | 21053930 |
| C043562 | flavone | flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C043562 | flavone | flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| D005436 | Floxacillin | CYP3A4 results in increased metabolism of Floxacillin | 11409940 |
| D015725 | Fluconazole | Fluconazole results in decreased activity of CYP3A4 protein | 15784650|1584349 |
| D015725 | Fluconazole | Fluconazole results in decreased activity of CYP3A4 protein | 10466905|1238805 |
| C108339 | fludioxonil | [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA | 25028461 |
| D005445 | Flunitrazepam | CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein] | 19005028 |
| D005445 | Flunitrazepam | CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP7 protein] | 19005028 |
| D005445 | Flunitrazepam | CYP3A4 protein results in increased hydroxylation of Flunitrazepam | 15383492 |
| D005445 | Flunitrazepam | CYP3A4 protein results in increased metabolism of and results in increased activity of Flunitrazepam | 19005028 |
| D005445 | Flunitrazepam | Flunitrazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D005445 | Flunitrazepam | Flunitrazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D005472 | Fluorouracil | Fluorouracil affects the expression of CYP3A4 mRNA | 16584549 |
| D005473 | Fluoxetine | CYP3A4 protein results in increased metabolism of Fluoxetine | 11752104|1659571 |
| D005473 | Fluoxetine | Fluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| D005473 | Fluoxetine | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Fluoxetine] | 11752104 |
| D005473 | Fluoxetine | Fluoxetine results in decreased activity of CYP3A4 protein | 9681092 |
| D005476 | Fluphenazine | Fluphenazine results in decreased activity of CYP3A4 protein | 15135088 |
| D005485 | Flutamide | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide | 23397584 |
| D005485 | Flutamide | CYP3A4 protein results in increased susceptibility to Flutamide | 28762043 |
| D005485 | Flutamide | Flutamide results in increased activity of CYP3A4 protein | 18839173 |
| D005485 | Flutamide | Flutamide results in increased expression of CYP3A4 mRNA | 18839173 |
| D005485 | Flutamide | [SOD2 co-treated with CYP3A4] affects the susceptibility to Flutamide | 19501153 |
| D005485 | Flutamide | [GCSH mRNA co-treated with CYP3A4 protein] affects the susceptibility to Flutamide | 19958826 |
| D000068298 | Fluticasone | Fluticasone results in decreased activity of CYP3A4 protein | 20707410 |
| C475882 | flutolanil | flutolanil results in increased expression of CYP3A4 mRNA | 17293382 |
| C065180 | fluvastatin | [fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 24204015 |
| C065180 | fluvastatin | fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] | 16029222 |
| C065180 | fluvastatin | fluvastatin results in decreased activity of CYP3A4 protein | 16029222 |
| D016666 | Fluvoxamine | Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| C000591719 | fluxapyroxad | [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 mRNA | 29294346 |
| C000591719 | fluxapyroxad | [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 protein | 29294346 |
| C000591719 | fluxapyroxad | fluxapyroxad results in increased expression of CYP3A4 mRNA | 29294346 |
| D004397 | Fonofos | Fonofos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| D004397 | Fonofos | Fonofos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| D004397 | Fonofos | Fonofos results in decreased activity of CYP3A4 protein | 16790556 |
| D005505 | Food Coloring Agents | Food Coloring Agents results in decreased activity of CYP3A4 protein | 18686201|2004101 |
| C009252 | fructus schizandrae, radix ginseng, radix ophiopogonis drug combination | "fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A4 protein affects the metabolism of Midazolam]" | 19557931 |
| D011564 | Furocoumarins | Furocoumarins results in decreased activity of CYP3A4 protein | 15969491 |
| D005672 | Fusidic Acid | Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 26888941 |
| D005688 | Galactosamine | alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CYP3A4 mRNA] | 17936189 |
| D005688 | Galactosamine | Galactosamine inhibits the reaction [alpha-Tocopherol results in increased expression of CYP3A4 mRNA] | 17936189 |
| D005688 | Galactosamine | Galactosamine inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 17936189 |
| D005688 | Galactosamine | Galactosamine results in decreased expression of CYP3A4 mRNA | 17936189 |
| C037032 | galangin | galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| C037032 | galangin | galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| C037032 | galangin | galangin results in decreased activity of CYP3A4 protein | 21053930 |
| C037032 | galangin | galangin results in increased expression of CYP3A4 mRNA | 26238175 |
| C419708 | gefitinib | CYP3A4 protein affects the metabolism of gefitinib | 15788367 |
| C419708 | gefitinib | CYP3A4 protein promotes the reaction [gefitinib binds to Glutathione] | 19803472 |
| C419708 | gefitinib | CYP3A4 protein results in increased activity of and results in increased metabolism of gefitinib | 19803472 |
| D015248 | Gemfibrozil | Gemfibrozil results in increased activity of CYP3A4 protein | 15771232 |
| D015248 | Gemfibrozil | Gemfibrozil results in increased expression of CYP3A4 mRNA | 15771232 |
| D019833 | Genistein | Genistein inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | 19766177 |
| D019833 | Genistein | Genistein results in decreased activity of CYP3A4 protein | 21053930 |
| C048393 | germacrone | germacrone results in decreased activity of CYP3A4 protein | 23850985 |
| C048393 | germacrone | germacrone results in increased expression of CYP3A4 mRNA | 23850985 |
| C033273 | Gestodene | Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] | 1740010 |
| C033273 | Gestodene | Gestodene results in decreased activity of CYP3A4 protein | 2271712 |
| C007845 | gingerol | gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| C063170 | Ginkgo biloba extract | Ginkgo biloba extract results in decreased activity of CYP3A4 protein | 15147983 |
| C063170 | Ginkgo biloba extract | Ginkgo biloba extract results in increased expression of CYP3A4 mRNA | 19034627 |
| C477042 | ginkgolide A | ginkgolide A results in increased expression of CYP3A4 mRNA | 19034627 |
| C045856 | ginkgolide B | ginkgolide B results in increased expression of CYP3A4 mRNA | 19034627|2677566 |
| C045856 | ginkgolide B | NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] | 26775663 |
| C045856 | ginkgolide B | sulforafan inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] | 26775663 |
| C057619 | glimepiride | [glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D005938 | Glucocorticoids | CYP3A4 protein results in increased metabolism of Glucocorticoids | 24555085 |
| D005938 | Glucocorticoids | [[Glucocorticoids binds to NR3C1 protein] which results in increased expression of NR1I2] which results in increased expression of CYP3A4 | 24555085 |
| D005938 | Glucocorticoids | [[Glucocorticoids binds to NR3C1 protein] which results in increased expression of NR1I3] which results in increased expression of CYP3A4 | 24555085 |
| D005947 | Glucose | Glucose results in decreased expression of CYP3A4 mRNA | 23245955 |
| D005978 | Glutathione | Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione] | 25451576 |
| D005978 | Glutathione | Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione] | 25451576 |
| D005978 | Glutathione | [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione | 25451576 |
| D005978 | Glutathione | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac | 24246759 |
| D005978 | Glutathione | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac | 24246759 |
| D005978 | Glutathione | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac | 24246759 |
| D005978 | Glutathione | [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac | 24246759 |
| D005978 | Glutathione | [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac | 24246759 |
| D005978 | Glutathione | "[CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine" | 20825217 |
| D005978 | Glutathione | [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione | 25451576 |
| D005978 | Glutathione | CYP3A4 protein promotes the reaction [Acetaminophen results in decreased abundance of Glutathione] | 27485346 |
| D005978 | Glutathione | Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol] | 18206979 |
| D005978 | Glutathione | Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 18206979 |
| D005978 | Glutathione | Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline] | 18206979 |
| D005978 | Glutathione | Glutathione binds to CYP3A4 protein | 18206979 |
| D005978 | Glutathione | Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein] | 15523003 |
| D005978 | Glutathione | Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac] | 24246759 |
| D005978 | Glutathione | Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] | 24246759 |
| D005978 | Glutathione | neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] | 25451576 |
| D005978 | Glutathione | [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of Raloxifene Hydrochloride | 22429462 |
| D005978 | Glutathione | CYP3A4 protein promotes the reaction [gefitinib binds to Glutathione] | 19803472 |
| D005978 | Glutathione | [GCSH mRNA co-treated with CYP3A4 protein] affects the abundance of Glutathione | 19958826 |
| D005905 | Glyburide | CYP3A4 protein results in increased metabolism of Glyburide | 15370958 |
| D019695 | Glycyrrhizic Acid | Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA | 22982774 |
| D019695 | Glycyrrhizic Acid | Glycyrrhizic Acid results in increased expression of CYP3A4 protein | 22982774 |
| D019695 | Glycyrrhizic Acid | NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA] | 22982774 |
| D017829 | Granisetron | CYP3A4 protein affects the metabolism of Granisetron | 15286053 |
| D006118 | Griseofulvin | Griseofulvin results in increased expression of CYP3A4 mRNA | 18505790 |
| D006118 | Griseofulvin | Griseofulvin results in increased expression of CYP3A4 protein | 18505790 |
| C018562 | guggulu extract | guggulu extract results in increased expression of CYP3A4 mRNA | 15075359 |
| C473027 | GW 3965 | [GW 3965 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA | 23732298 |
| C473027 | GW 3965 | GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 23732298 |
| C473027 | GW 3965 | GW 3965 results in increased expression of CYP3A4 mRNA | 23732298 |
| D006220 | Haloperidol | CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol | 12584149 |
| D006220 | Haloperidol | Fluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| D006220 | Haloperidol | Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| D006220 | Haloperidol | nefazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| D006220 | Haloperidol | norfluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| D006220 | Haloperidol | Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| D006221 | Halothane | CYP3A4 protein results in increased metabolism of Halothane | 8886607 |
| D006418 | Heme | [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine] | 22390216 |
| D006418 | Heme | [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] | 22390216 |
| C001335 | hexachlorobutadiene | CYP3A4 protein results in increased metabolism of hexachlorobutadiene | 8555406 |
| C058039 | hexafluoron | hexafluoron results in increased expression of CYP3A4 mRNA | 22310298 |
| D006591 | Hexobarbital | Hexobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D006591 | Hexobarbital | Hexobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D017313 | Fenretinide | Fenretinide promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| D006854 | Hydrocortisone | CYP3A4 promoter mutant form inhibits the reaction [Hydrocortisone results in increased expression of CYP3A4 mRNA] | 12505310|1250531 |
| D006854 | Hydrocortisone | CYP3A4 protein affects the hydroxylation of Hydrocortisone | 2271712 |
| D006854 | Hydrocortisone | CYP3A4 protein affects the metabolism of Hydrocortisone | 15025748|1594167 |
| D006854 | Hydrocortisone | CYP3A4 protein results in increased metabolism of Hydrocortisone | 11907490 |
| D006854 | Hydrocortisone | Hydrocortisone results in increased expression of CYP3A4 mRNA | 12505310|2322349 |
| D006854 | Hydrocortisone | kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] | 15266218 |
| D006854 | Hydrocortisone | Quercetin inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] | 15266218 |
| D006861 | Hydrogen Peroxide | CYP3A4 protein results in increased abundance of Hydrogen Peroxide | 25061110 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of CYP3A4 mRNA | 15056853 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of CYP3A4 protein | 15056853 |
| D006861 | Hydrogen Peroxide | [CYP3A4 protein mutant form co-treated with Hydrogen Peroxide] results in increased metabolism of 7-benzyloxyquinoline | 16987939 |
| C031927 | hydroquinone | [CYP3A4 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone | 21402134 |
| C092333 | hydroxynefazodone | [CYP3A4 protein results in increased hydroxylation of nefazodone] which results in increased abundance of hydroxynefazodone | 27485346 |
| D006915 | Hydroxytestosterones | [CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones | 28238727 |
| D006915 | Hydroxytestosterones | Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones] | 28238727 |
| C010471 | hyodeoxycholic acid | [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid | 19487251 |
| C058309 | hypaconitine | CYP3A4 protein results in increased metabolism of hypaconitine | 21550385 |
| C001654 | hyperforin | hyperforin results in decreased activity of CYP3A4 protein | 15100173 |
| C001654 | hyperforin | hyperforin results in increased expression of and results in increased activity of CYP3A4 protein | 15100173 |
| C001654 | hyperforin | hyperforin results in increased expression of CYP3A4 | 16005588 |
| C001654 | hyperforin | hyperforin results in increased expression of CYP3A4 mRNA | 15100173|1526621 |
| C001654 | hyperforin | hyperforin results in increased expression of CYP3A4 | 21561094 |
| C004965 | hypericin | hypericin results in decreased activity of CYP3A4 protein | 15266218 |
| C004965 | hypericin | hypericin results in decreased expression of CYP3A4 mRNA | 15266218 |
| C004965 | hypericin | hypericin results in increased expression of CYP3A4 | 16005588 |
| D007069 | Ifosfamide | CYP3A4 gene mutant form results in decreased ethylation of Ifosfamide | 15821045 |
| D007069 | Ifosfamide | CYP3A4 protein affects the degradation of Ifosfamide | 12136253 |
| D007069 | Ifosfamide | CYP3A4 protein affects the hydroxylation of Ifosfamide | 12136253 |
| D007069 | Ifosfamide | CYP3A4 protein affects the metabolism of Ifosfamide | 15875221 |
| D007069 | Ifosfamide | CYP3A4 protein results in decreased ethylation of Ifosfamide | 15821045 |
| D007069 | Ifosfamide | CYP3A4 protein results in increased susceptibility to Ifosfamide | 20507880 |
| D007069 | Ifosfamide | CYP3A4 results in increased susceptibility to Ifosfamide | 9766669 |
| D007069 | Ifosfamide | Ifosfamide results in increased expression of CYP3A4 mRNA | 18839173 |
| D007069 | Ifosfamide | CYP3A4 protein results in increased hydroxylation of and results in increased susceptibility to Ifosfamide | 15919850 |
| D000068877 | Imatinib Mesylate | CYP3A4 protein results in decreased methylation of Imatinib Mesylate | 20977456 |
| D000068877 | Imatinib Mesylate | Imatinib Mesylate results in decreased activity of CYP3A4 protein | 21112467 |
| C082359 | imidacloprid | [NADP co-treated with CYP3A4 protein] results in increased activity of imidacloprid analog | 16153789 |
| D007093 | Imidazoles | "Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 21778469 |
| D007093 | Imidazoles | "Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 protein]" | 21778469 |
| D007099 | Imipramine | CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine | 15922009 |
| D007099 | Imipramine | Organophosphorus Compounds inhibits the reaction [CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine] | 15922009 |
| D007211 | Indoles | CYP3A4 protein results in increased glutathionylation of Indoles | 22429462 |
| C057812 | indoline | CYP3A4 protein results in increased metabolism of indoline | 17502430 |
| C489645 | indomethacin phenethylamide | CYP3A4 protein results in increased metabolism of indomethacin phenethylamide | 14709628 |
| D007460 | Iodoacetamide | Iodoacetamide inhibits the reaction [Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein] | 17497897 |
| D007460 | Iodoacetamide | Iodoacetamide results in increased alkylation of CYP3A4 protein | 17497897 |
| C033148 | iprodione | [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA | 25028461 |
| C051890 | irinotecan | CYP3A4 mRNA results in increased susceptibility to irinotecan | 15239142 |
| C051890 | irinotecan | CYP3A4 protein affects the metabolism of irinotecan | 15523087|1565554 |
| C051890 | irinotecan | CYP3A4 protein results in increased oxidation of irinotecan | 15100172 |
| C051890 | irinotecan | irinotecan metabolite results in decreased activity of CYP3A4 protein | 11901092 |
| C051890 | irinotecan | irinotecan results in decreased activity of CYP3A4 protein | 11901092 |
| C051890 | irinotecan | CYP3A4 protein results in increased metabolism of irinotecan | 16271446 |
| C549713 | isocarbophos | CYP3A4 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos | 24752505 |
| C035019 | isofenphos | isofenphos results in increased expression of CYP3A4 mRNA | 17293382 |
| C018326 | isomalathion | [Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA | 24333466 |
| D007538 | Isoniazid | CYP3A4 protein results in increased susceptibility to Isoniazid | 21540358 |
| D007538 | Isoniazid | Isoniazid results in decreased activity of CYP3A4 protein | 15005856|1530452 |
| D007538 | Isoniazid | [SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid | 19501153 |
| C023889 | isoprothiolane | isoprothiolane results in increased expression of CYP3A4 mRNA | 17293382 |
| C028904 | isoproturon | isoproturon results in decreased activity of CYP3A4 protein | 18420780 |
| C028904 | isoproturon | isoproturon results in increased activity of CYP3A4 protein | 22310298 |
| C028904 | isoproturon | isoproturon results in increased expression of CYP3A4 mRNA | 22310298 |
| D007546 | Isoquinolines | Acetylcysteine affects the reaction [[CYP3A4 protein co-treated with NADP] results in increased metabolism of Isoquinolines] | 21395287 |
| D007546 | Isoquinolines | [CYP3A4 protein co-treated with NADP] results in increased metabolism of Isoquinolines | 21395287 |
| C015959 | isosafrole | isosafrole results in increased expression of CYP3A4 protein | 8632764 |
| D007555 | Isoxazoles | Isoxazoles analog results in decreased activity of CYP3A4 protein | 21924250 |
| D017275 | Isradipine | CYP3A4 protein affects the metabolism of Isradipine | 15286053 |
| D017275 | Isradipine | Isradipine results in increased expression of and results in decreased activity of CYP3A4 protein | 27732883 |
| D017275 | Isradipine | Isradipine results in increased expression of CYP3A4 mRNA | 27732883 |
| D017964 | Itraconazole | CYP3A4 protein affects the metabolism of Itraconazole | 15905803 |
| D017964 | Itraconazole | CYP3A4 protein results in increased hydroxylation of Itraconazole | 15383492 |
| D017964 | Itraconazole | CYP3A4 protein results in increased metabolism of Itraconazole | 18360572 |
| D017964 | Itraconazole | Itraconazole affects the activity of CYP3A4 protein | 15964336 |
| D017964 | Itraconazole | Itraconazole binds to and results in decreased activity of CYP3A4 protein | 18218784 |
| D017964 | Itraconazole | Itraconazole results in decreased activity of CYP3A4 protein | 15328084|1544773 |
| D017964 | Itraconazole | Itraconazole results in decreased expression of CYP3A4 mRNA | 28390928 |
| D017964 | Itraconazole | Itraconazole results in decreased expression of CYP3A4 protein | 28390928 |
| D017964 | Itraconazole | Itraconazole inhibits the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 19954708 |
| D017964 | Itraconazole | Itraconazole results in decreased activity of CYP3A4 protein | 12388057|1655608 |
| C088408 | ivabradine | CYP3A4 protein affects the metabolism of ivabradine | 16988209 |
| D007559 | Ivermectin | Ivermectin results in decreased activity of CYP3A4 protein | 11124226|1842078 |
| D007559 | Ivermectin | Ivermectin results in increased expression of CYP3A4 mRNA | 26443706 |
| C006552 | kaempferol | kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] | 15266218 |
| C006552 | kaempferol | kaempferol results in decreased activity of CYP3A4 protein | 15266218|2105393 |
| C006552 | kaempferol | [kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| C006552 | kaempferol | kaempferol results in increased expression of CYP3A4 mRNA | 16442130 |
| D007649 | Ketamine | Ketamine results in decreased expression of and results in decreased activity of CYP3A4 protein | 18845661 |
| D007649 | Ketamine | Ketamine results in decreased expression of CYP3A4 mRNA | 18845661 |
| D007654 | Ketoconazole | CYP3A4 protein results in increased metabolism of Ketoconazole | 17702393 |
| D007654 | Ketoconazole | CYP3A4 protein results in increased susceptibility to Ketoconazole | 12695342|1880973 |
| D007654 | Ketoconazole | Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D007654 | Ketoconazole | Ketoconazole binds to and results in decreased activity of CYP3A4 protein | 28887089 |
| D007654 | Ketoconazole | "Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]" | 25542144 |
| D007654 | Ketoconazole | "Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 16608920 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA] | 22785256 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA] | 22785256 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | 12072427 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA] | 12072427 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan] | 16855053 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine] | 15896247 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac] | 24246759 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] | 24246759 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]] | 21566342 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]] | 21566342 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam] | 12695342 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam] | 9600717 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam] | 9600717 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam] | 12695342 |
| D007654 | Ketoconazole | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]" | 12675279 |
| D007654 | Ketoconazole | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]" | 12675279 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342|2023384 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel] | 12237780 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| D007654 | Ketoconazole | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]" | 12675279 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 20233841|2086332 |
| D007654 | Ketoconazole | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]" | 12675279 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide] | 18809730 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine] | 18809730 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of clopidogrel] | 22651985 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine] | 22651985 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine] | 19358519 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | 11377097 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran] | 15560889 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | 16207822 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 12695342|2023384 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone] | 27485346 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone] | 27485346 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine] | 18846481 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 20233841|2086332 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 28238727 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones] | 28238727 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate] | 26286065 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate] | 16390352 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid] | 12675279 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin] | 22178124 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin] | 22178124 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan] | 20307514 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin] | 22178124 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol] | 26038696 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine] | 23876819 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] | 15764719 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 23850985|2811916 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine] | 15869686 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | 12569440|2385098 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam] | 10952769 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758] | 19230594 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel] | 19812348 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan] | 19593786 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine] | 20863320|2314603 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel] | 12237780 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to clopidogrel] | 22651985 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan] | 20507880 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine] | 22651985 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA] | 22785256 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA] | 22785256 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]] | 23707768 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]] | 23707768 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] | 23707768 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]] | 23707768 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA] | 16819505|1743810 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein] | 16819505 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 16608920 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | 21402137 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] | 16146350 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 16608920|1681950 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 16819505 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein] | 24819614 |
| D007654 | Ketoconazole | Ketoconazole results in decreased activity of CYP3A4 protein | 10997946|1500585 |
| D007654 | Ketoconazole | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam | 10997946 |
| D007654 | Ketoconazole | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine | 11502731 |
| D007654 | Ketoconazole | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam | 10997946 |
| D007654 | Ketoconazole | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam | 25343516 |
| D007654 | Ketoconazole | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone | 25343516 |
| D007654 | Ketoconazole | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam | 22447115 |
| D007654 | Ketoconazole | Ketoconazole results in increased expression of and results in decreased activity of CYP3A4 protein | 25343516 |
| D007654 | Ketoconazole | Ketoconazole results in increased expression of CYP3A4 mRNA | 17998298|2534351 |
| D007654 | Ketoconazole | Ketoconazole results in decreased activity of CYP3A4 protein | 18420780 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 21964476 |
| D007654 | Ketoconazole | "Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione]" | 21964476 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [[NR1I2 binds to HNF4A] which results in increased expression of CYP3A4] | 19077665 |
| D007654 | Ketoconazole | Ketoconazole results in decreased activity of CYP3A4 protein | 12388057|1470962 |
| D007654 | Ketoconazole | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of brucine | 23707193 |
| D007654 | Ketoconazole | Ketoconazole results in decreased expression of CYP3A4 | 19077665 |
| C094644 | L 754394 | L 754394 results in decreased activity of CYP3A4 protein | 10997946 |
| C094644 | L 754394 | [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam | 10997946 |
| C094644 | L 754394 | [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam | 10997946 |
| C067713 | lactacystin | "lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]" | 24224465 |
| C067713 | lactacystin | lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 24224465 |
| C047781 | lamotrigine | CYP3A4 protein results in increased glutathionylation of lamotrigine | 19961160 |
| D064747 | Lansoprazole | CYP3A4 protein affects the metabolism of Lansoprazole | 15010519 |
| D064747 | Lansoprazole | CYP3A4 protein results in increased hydroxylation of Lansoprazole | 12975331|8627562 |
| D064747 | Lansoprazole | CYP3A4 protein results in increased metabolism of Lansoprazole | 11829200|1297533 |
| D064747 | Lansoprazole | Lansoprazole results in increased expression of CYP3A4 mRNA | 10859152 |
| D064747 | Lansoprazole | Lansoprazole results in increased expression of CYP3A4 protein | 9744552 |
| D064747 | Lansoprazole | CYP3A4 protein results in increased metabolism of Lansoprazole | 15370958 |
| D064747 | Lansoprazole | Lansoprazole results in decreased activity of CYP3A4 protein | 16988209 |
| C490728 | lapatinib | CYP3A4 protein results in increased metabolism of lapatinib | 26958860 |
| C490728 | lapatinib | [CYP3A4 protein results in increased metabolism of lapatinib] which results in increased activity of NFE2L2 protein | 26958860 |
| C490728 | lapatinib | [CYP3A4 protein results in increased metabolism of lapatinib] which results in increased expression of HMOX1 mRNA | 26958860 |
| C490728 | lapatinib | [CYP3A4 protein results in increased metabolism of lapatinib] which results in increased expression of NQO1 mRNA | 26958860 |
| C490728 | lapatinib | [CYP3A4 protein results in increased metabolism of lapatinib] which results in increased expression of SOD1 mRNA | 26958860 |
| C490728 | lapatinib | [CYP3A4 protein results in increased metabolism of lapatinib] which results in increased expression of SOD2 mRNA | 26958860 |
| C476223 | laquinimod | CYP3A4 protein results in increased metabolism of laquinimod | 15764719 |
| C476223 | laquinimod | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] | 15764719 |
| C476223 | laquinimod | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] | 15764719 |
| D007854 | Lead | Lead results in increased expression of CYP3A4 mRNA | 19921347 |
| C045463 | leflunomide | CYP3A4 protein results in increased metabolism of and results in decreased susceptibility to leflunomide | 25860621 |
| C045463 | leflunomide | CYP3A4 protein results in increased susceptibility to leflunomide | 21540358 |
| C045463 | leflunomide | [leflunomide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| C011896 | lephetamine | CYP3A4 protein results in decreased alkylation of lephetamine | 26276083 |
| C038753 | leptomycin B | [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CYP3A4 mRNA | 25922640 |
| C038753 | leptomycin B | leptomycin B results in increased expression of CYP3A4 mRNA | 25922640 |
| C067431 | letrozole | CYP3A4 protein results in increased oxidation of letrozole | 19845430 |
| C070840 | licochalcone A | licochalcone A results in decreased activity of CYP3A4 protein | 26100226 |
| D008012 | Lidocaine | CYP3A4 protein affects the metabolism of Lidocaine | 15447735 |
| D008012 | Lidocaine | CYP3A4 protein results in decreased ethylation of Lidocaine | 15887009 |
| D008012 | Lidocaine | CYP3A4 protein results in decreased methylation of Lidocaine | 15383492 |
| D008012 | Lidocaine | CYP3A4 protein results in increased metabolism of Lidocaine | 18846481 |
| D008012 | Lidocaine | Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine] | 9298257 |
| C080095 | liensinine | CYP3A4 protein results in increased chemical synthesis of liensinine | 25451576 |
| C027820 | ligustilide | [ligustilide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 21524698 |
| C008281 | limonene | limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| C001546 | limonin | limonin results in decreased activity of CYP3A4 protein | 22001672 |
| D001556 | Lindane | Lindane results in increased expression of CYP3A4 protein | 15548381 |
| D001556 | Lindane | Lindane results in increased expression of CYP3A4 mRNA | 18804290 |
| D008044 | Linuron | [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA | 25028461 |
| D008044 | Linuron | [Diethylhexyl Phthalate co-treated with Linuron] results in increased expression of CYP3A4 mRNA | 22277248 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of CYP3A4 mRNA" | 26220752 |
| D008070 | Lipopolysaccharides | [TNF protein co-treated with IL1B protein co-treated with IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of CYP3A4 mRNA | 20816778 |
| D008095 | Lithocholic Acid | CYP3A4 protein affects the metabolism of Lithocholic Acid | 15708356 |
| D008095 | Lithocholic Acid | CYP3A4 protein results in increased metabolism of Lithocholic Acid | 19487251 |
| D008095 | Lithocholic Acid | [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of 3-ketocholanoic acid | 19487251 |
| D008095 | Lithocholic Acid | [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid | 19487251 |
| D008095 | Lithocholic Acid | [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic Acid | 19487251 |
| D008095 | Lithocholic Acid | [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA | 15489543|1557859 |
| D008095 | Lithocholic Acid | Lithocholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D008095 | Lithocholic Acid | Lithocholic Acid results in increased activity of CYP3A4 protein mutant form | 19299527 |
| D008095 | Lithocholic Acid | Lithocholic Acid results in increased expression of CYP3A4 mRNA | 17965521|1864503 |
| D008095 | Lithocholic Acid | VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA] | 18645036 |
| D008095 | Lithocholic Acid | Lithocholic Acid results in decreased activity of CYP3A4 protein | 18420780 |
| D008095 | Lithocholic Acid | Lithocholic Acid results in increased expression of CYP3A4 mRNA | 18645036 |
| D008095 | Lithocholic Acid | Lithocholic Acid results in increased expression of CYP3A4 protein | 18645036 |
| D008095 | Lithocholic Acid | VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA] | 18645036 |
| D008095 | Lithocholic Acid | VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 protein] | 18645036 |
| D008095 | Lithocholic Acid | Lithocholic Acid promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP3A4 promoter] | 15992766 |
| C502354 | lithocholic acid acetate | [lithocholic acid acetate binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA | 15489543 |
| D061466 | Lopinavir | CAT protein inhibits the reaction [Lopinavir results in decreased activity of CYP3A4 protein] | 15523003 |
| D061466 | Lopinavir | Lopinavir results in decreased activity of CYP3A4 protein | 15523003 |
| D017336 | Loratadine | Loratadine analog results in decreased activity of CYP3A4 protein | 15482930 |
| D017336 | Loratadine | Loratadine results in decreased activity of CYP3A4 protein | 15482930 |
| D017336 | Loratadine | CYP3A4 protein affects the metabolism of Loratadine | 15932952 |
| D019808 | Losartan | CYP3A4 protein results in increased metabolism of Losartan | 10197301 |
| D008148 | Lovastatin | [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D008148 | Lovastatin | Lovastatin results in increased expression of CYP3A4 mRNA | 12505310 |
| D008148 | Lovastatin | CYP3A4 protein results in increased metabolism of Lovastatin | 12243603 |
| D008152 | Loxapine | CYP3A4 results in increased metabolism of Loxapine | 21826677 |
| D047311 | Luteolin | Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 18191104 |
| D047311 | Luteolin | Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 18191104 |
| C015329 | lycopene | lycopene results in increased activity of CYP3A4 protein | 16632523 |
| D018942 | Macrolides | Macrolides results in decreased activity of CYP3A4 protein | 16556082 |
| C093443 | madecassoside | madecassoside results in decreased activity of CYP3A4 protein | 21349323 |
| D015636 | Magnesium Chloride | Magnesium Chloride affects the reaction [CYP3A4 protein results in increased metabolism of Triazolam] | 10997940 |
| D015636 | Magnesium Chloride | Magnesium Chloride affects the reaction [CYP3A4 protein results in increased oxidation of pyrene] | 10997940 |
| D008294 | Malathion | CYP3A4 protein affects the metabolism of Malathion | 15557345|1711006 |
| D008294 | Malathion | [Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA | 24333466 |
| D008294 | Malathion | Malathion results in increased expression of CYP3A4 mRNA | 22310298 |
| D008300 | Maleic Hydrazide | [Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA | 25028461 |
| C501277 | Mangifera indica extract | Mangifera indica extract results in decreased activity of CYP3A4 protein | 22815239 |
| C013592 | mangiferin | mangiferin results in decreased activity of CYP3A4 protein | 22815239 |
| D008468 | Meclizine | Meclizine results in decreased activity of CYP3A4 protein | 26239802 |
| D008468 | Meclizine | [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 6 beta-hydroxytestosterone | 26239802 |
| D008468 | Meclizine | [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Testosterone | 26239802 |
| D008468 | Meclizine | Meclizine results in increased expression of CYP3A4 mRNA | 26239802 |
| D008472 | Medazepam | Medazepam results in increased expression of CYP3A4 mRNA | 20080160 |
| D017258 | Medroxyprogesterone Acetate | Medroxyprogesterone Acetate results in increased expression of CYP3A4 mRNA | 15650019 |
| D017258 | Medroxyprogesterone Acetate | Medroxyprogesterone Acetate results in increased expression of CYP3A4 protein | 15650019 |
| D008528 | Mefenamic Acid | CYP3A4 protein results in increased glutathionylation of Mefenamic Acid analog | 25372302 |
| D008528 | Mefenamic Acid | CYP3A4 protein results in increased hydroxylation of Mefenamic Acid | 25372302 |
| D015767 | Mefloquine | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine] | 15896247 |
| D008549 | Melarsoprol | Melarsoprol results in decreased activity of CYP3A4 protein | 11124226 |
| C030814 | menatetrenone | menatetrenone results in increased expression of CYP3A4 | 21561094 |
| D008610 | Menthol | Menthol results in increased expression of CYP3A4 mRNA | 24594507 |
| D008617 | Mephenytoin | Mephenytoin results in decreased activity of CYP3A4 protein | 18420780 |
| C050699 | mepirodipine | mepirodipine results in decreased activity of CYP3A4 protein | 10805063 |
| D008687 | Metformin | Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 21920351 |
| D008687 | Metformin | Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 21920351 |
| D008687 | Metformin | Metformin results in decreased expression of CYP3A4 mRNA | 21920351 |
| D008687 | Metformin | Metformin results in increased expression of CYP3A4 mRNA | 19022234 |
| D008687 | Metformin | Metformin inhibits the reaction [NR1I3 protein results in increased expression of CYP3A4 mRNA] | 21920351 |
| D008687 | Metformin | Metformin inhibits the reaction [NR3C1 protein results in increased expression of CYP3A4 mRNA] | 21920351 |
| D008687 | Metformin | Metformin inhibits the reaction [VDR protein results in increased expression of CYP3A4 mRNA] | 21920351 |
| D008691 | Methadone | CYP3A4 protein affects the metabolism of Methadone | 15986265 |
| D008691 | Methadone | CYP3A4 protein results in increased metabolism of Methadone | 16595712 |
| D008691 | Methadone | CYP3A4 protein affects the metabolism of Methadone | 11145498 |
| D008694 | Methamphetamine | CYP3A4 protein affects the metabolism of Methamphetamine metabolite | 16038959 |
| D008694 | Methamphetamine | [Methamphetamine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | 12851153|1285115 |
| C005828 | methidathion | [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA | 25028461 |
| D003915 | Dextromethorphan | CYP3A4 protein affects the metabolism of Dextromethorphan | 15988119 |
| D003915 | Dextromethorphan | CYP3A4 protein results in decreased methylation of Dextromethorphan | 15383492 |
| D003915 | Dextromethorphan | CYP3A4 protein results in increased metabolism of Dextromethorphan | 16595712|1726729 |
| D003915 | Dextromethorphan | CYP3A4 protein results in increased oxidation of Dextromethorphan | 15383492 |
| D003915 | Dextromethorphan | Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein] | 19818743 |
| D003915 | Dextromethorphan | Dextromethorphan results in decreased activity of CYP3A4 protein | 18420780 |
| D003915 | Dextromethorphan | CYP3A4 protein results in increased metabolism of Dextromethorphan | 21606622 |
| D003915 | Dextromethorphan | [CYP3A4 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of 3-methoxymorphinan | 21606622 |
| D008727 | Methotrexate | Methotrexate results in decreased expression of CYP3A4 mRNA | 16837568 |
| D008731 | Methoxychlor | [Endosulfan co-treated with Methoxychlor] results in increased activity of CYP3A4 protein | 24832206 |
| D008731 | Methoxychlor | Endosulfan promotes the reaction [Methoxychlor results in increased expression of CYP3A4 mRNA] | 24832206 |
| D008731 | Methoxychlor | Methoxychlor promotes the reaction [Endosulfan results in increased expression of CYP3A4 mRNA] | 24832206 |
| D008731 | Methoxychlor | Methoxychlor results in decreased activity of CYP3A4 protein | 18420780 |
| D008731 | Methoxychlor | Methoxychlor results in increased activity of CYP3A4 protein | 24832206 |
| D008731 | Methoxychlor | Methoxychlor results in increased expression of CYP3A4 mRNA | 15466163|2483220 |
| D008731 | Methoxychlor | Methoxychlor results in increased expression of CYP3A4 protein | 15548381 |
| D008731 | Methoxychlor | CYP3A4 protein results in decreased methylation of Methoxychlor | 12433799 |
| D008733 | Methoxyflurane | CYP3A4 protein results in increased metabolism of Methoxyflurane | 7879937 |
| C066998 | methoxy-morpholinyl-doxorubicin | [CYP3A4 protein co-treated with POR protein] results in increased metabolism of methoxy-morpholinyl-doxorubicin | 15465924 |
| C066998 | methoxy-morpholinyl-doxorubicin | CYP3A4 protein results in increased metabolism of methoxy-morpholinyl-doxorubicin | 15465924 |
| D008730 | Methoxsalen | Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] | 17003103 |
| D008730 | Methoxsalen | Methoxsalen results in decreased activity of CYP3A4 protein | 18420780 |
| D008730 | Methoxsalen | Methoxsalen results in increased expression of CYP3A4 mRNA | 17003103 |
| D008730 | Methoxsalen | Methoxsalen results in increased expression of CYP3A4 protein | 17003103 |
| D008730 | Methoxsalen | NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] | 17003103 |
| D008748 | Methylcholanthrene | [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA | 24999631 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in decreased expression of and results in decreased activity of CYP3A4 protein | 23846873 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in decreased expression of CYP3A4 protein | 10640517 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in decreased expression of CYP3A4 mRNA | 18804290 |
| D008753 | Methylenebis(chloroaniline) | alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] | 1740010 |
| D008753 | Methylenebis(chloroaniline) | CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline) | 1740010 |
| D008753 | Methylenebis(chloroaniline) | Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] | 1740010 |
| D008753 | Methylenebis(chloroaniline) | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] | 1740010 |
| D012862 | Skatole | Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 28571685 |
| D012862 | Skatole | Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 28571685 |
| D012862 | Skatole | Skatole results in decreased expression of CYP3A4 mRNA | 28571685 |
| D008767 | Methylmercury Compounds | CYP3A4 protein results in decreased susceptibility to Methylmercury Compounds | 22699155 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [1-(3-chlorophenyl)piperazine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Amphetamine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of CYP3A4 protein" | 24211539 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "CYP3A4 affects the metabolism of N-Methyl-3,4-methylenedioxyamphetamine" | 21871945 |
| D008775 | Methylprednisolone | Methylprednisolone results in decreased expression of CYP3A4 mRNA | 16837568 |
| D008775 | Methylprednisolone | Methylprednisolone results in increased activity of CYP3A4 protein | 15964336 |
| C051786 | metolachlor | CYP3A4 protein results in increased metabolism of metolachlor | 11133395 |
| C051786 | metolachlor | metolachlor results in increased expression of CYP3A4 mRNA | 16565514 |
| D008788 | Metolazone | [Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D008795 | Metronidazole | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone] | 15869686 |
| D008795 | Metronidazole | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Tacrolimus] | 15855244 |
| D008795 | Metronidazole | Metronidazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D008795 | Metronidazole | Metronidazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D008795 | Metronidazole | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Quinidine] | 15869686 |
| D008795 | Metronidazole | Metronidazole results in decreased activity of CYP3A4 protein | 15855244|1586968 |
| D008797 | Metyrapone | [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D008797 | Metyrapone | Metyrapone results in increased expression of CYP3A4 mRNA | 10219967|1250531 |
| C012258 | mevastatin | [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| C012258 | mevastatin | mevastatin results in increased expression of CYP3A4 mRNA | 12235278|1546616 |
| C012258 | mevastatin | NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] | 12235278 |
| D020748 | Mibefradil | Mibefradil results in decreased activity of CYP3A4 protein | 15860655 |
| D008825 | Miconazole | Miconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D008825 | Miconazole | Miconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] | 17998298 |
| D008825 | Miconazole | Miconazole results in decreased activity of CYP3A4 protein | 15135088|1596993 |
| D008825 | Miconazole | Miconazole results in increased expression of CYP3A4 mRNA | 17998298 |
| D008825 | Miconazole | Miconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D008874 | Midazolam | CYP3A4 protein affects the metabolism of Midazolam | 15801540 |
| D008874 | Midazolam | acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| D008874 | Midazolam | acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| D008874 | Midazolam | allyl methyl disulfide inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D008874 | Midazolam | Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 22652334 |
| D008874 | Midazolam | Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| D008874 | Midazolam | Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| D008874 | Midazolam | Atorvastatin Calcium inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] | 16029222 |
| D008874 | Midazolam | bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| D008874 | Midazolam | bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| D008874 | Midazolam | [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| D008874 | Midazolam | caryophyllene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D008874 | Midazolam | cinobufagin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| D008874 | Midazolam | citral inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D008874 | Midazolam | Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D008874 | Midazolam | CYP3A4 gene polymorphism affects the metabolism of Midazolam | 15900284 |
| D008874 | Midazolam | CYP3A4 protein affects the metabolism of Midazolam | 15286053|1562658 |
| D008874 | Midazolam | CYP3A4 protein inhibits the reaction [Rifampin results in decreased hydroxylation of Midazolam] | 12695342 |
| D008874 | Midazolam | CYP3A4 protein results in decreased abundance of Midazolam | 12695342 |
| D008874 | Midazolam | CYP3A4 protein results in increased glucuronidation of Midazolam | 27485346 |
| D008874 | Midazolam | CYP3A4 protein results in increased hydroxylation of Midazolam | 12433797|1269534 |
| D008874 | Midazolam | [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam | 27485346 |
| D008874 | Midazolam | [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam | 27485346 |
| D008874 | Midazolam | CYP3A4 protein results in increased metabolism of Midazolam | 12401345|1246791 |
| D008874 | Midazolam | CYP3A4 protein results in increased oxidation of Midazolam | 21053930 |
| D008874 | Midazolam | [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam | 21053930 |
| D008874 | Midazolam | [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam | 21053930 |
| D008874 | Midazolam | deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 23876819 |
| D008874 | Midazolam | [Dexamethasone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| D008874 | Midazolam | Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 22652334 |
| D008874 | Midazolam | eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D008874 | Midazolam | flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| D008874 | Midazolam | flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| D008874 | Midazolam | flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| D008874 | Midazolam | flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| D008874 | Midazolam | fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] | 16029222 |
| D008874 | Midazolam | "fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A4 protein affects the metabolism of Midazolam]" | 19557931 |
| D008874 | Midazolam | Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 26888941 |
| D008874 | Midazolam | galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] | 21053930 |
| D008874 | Midazolam | galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 21053930 |
| D008874 | Midazolam | gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D008874 | Midazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam] | 12695342 |
| D008874 | Midazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 12695342|2023384 |
| D008874 | Midazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 23850985|2811916 |
| D008874 | Midazolam | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam | 10997946 |
| D008874 | Midazolam | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam | 25343516 |
| D008874 | Midazolam | [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam | 10997946 |
| D008874 | Midazolam | limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 18385293 |
| D008874 | Midazolam | Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | 8114683 |
| D008874 | Midazolam | Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| D008874 | Midazolam | Midazolam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D008874 | Midazolam | Midazolam results in increased expression of CYP3A4 mRNA | 20080160 |
| D008874 | Midazolam | Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 22652334 |
| D008874 | Midazolam | Mifepristone inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 16049126 |
| D008874 | Midazolam | muscone promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| D008874 | Midazolam | Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 15043991 |
| D008874 | Midazolam | pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 15258107 |
| D008874 | Midazolam | [pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| D008874 | Midazolam | potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]] | 22652334 |
| D008874 | Midazolam | potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]] | 22652334 |
| D008874 | Midazolam | rabeprazole-thioether inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 15258107 |
| D008874 | Midazolam | Rifampin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 12695342 |
| D008874 | Midazolam | Rifampin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 20233841 |
| D008874 | Midazolam | [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| D008874 | Midazolam | shexiang baoxin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| D008874 | Midazolam | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 12695342 |
| D008874 | Midazolam | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 16049126 |
| D008874 | Midazolam | YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 19230594 |
| D008874 | Midazolam | zafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 15370959 |
| D008874 | Midazolam | Midazolam results in decreased activity of CYP3A4 protein | 18420780 |
| D008874 | Midazolam | CYP3A4 protein affects the metabolism of Midazolam | 15801540 |
| D008874 | Midazolam | brucine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 23707193 |
| D008874 | Midazolam | CYP3A4 protein results in increased hydroxylation of Midazolam | 23707193 |
| D008874 | Midazolam | CYP3A4 protein results in increased metabolism of Midazolam | 11231118|2217812 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 22652334 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 22652334 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 16049126 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [NR3C1 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA]] | 10219967 |
| D015735 | Mifepristone | Mifepristone results in decreased activity of CYP3A4 protein | 15860655|1604912 |
| D015735 | Mifepristone | [Mifepristone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D015735 | Mifepristone | Mifepristone results in increased expression of CYP3A4 mRNA | 12235278|1546616 |
| D015735 | Mifepristone | NR1I2 protein promotes the reaction [Mifepristone results in increased expression of CYP3A4 mRNA] | 12235278 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [[Diethylhexyl Phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [[mono-(2-ethylhexyl)phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| C001801 | mitragynine | mitragynine results in increased activity of CYP3A4 protein | 23274770 |
| C001801 | mitragynine | mitragynine results in increased expression of CYP3A4 mRNA | 23274770 |
| C001801 | mitragynine | mitragynine results in increased expression of CYP3A4 protein | 23274770 |
| C518174 | MK-0524 | CYP3A4 protein results in increased metabolism of MK-0524 | 17132765 |
| C479069 | mono(2-ethyl-5-hydroxyhexyl) phthalate | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate | 23545481 |
| C080276 | mono(2-ethyl-5-oxohexyl)phthalate | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate | 23545481 |
| C016599 | mono-(2-ethylhexyl)phthalate | CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate | 22186153|2354548 |
| C016599 | mono-(2-ethylhexyl)phthalate | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate | 23545481 |
| C016599 | mono-(2-ethylhexyl)phthalate | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate | 23545481 |
| C016599 | mono-(2-ethylhexyl)phthalate | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid | 22186153|2354548 |
| C016599 | mono-(2-ethylhexyl)phthalate | [Dexamethasone co-treated with mono-(2-ethylhexyl)phthalate] results in increased activity of CYP3A4 protein | 18332045 |
| C016599 | mono-(2-ethylhexyl)phthalate | mono-(2-ethylhexyl)phthalate results in increased expression of CYP3A4 mRNA | 27551952 |
| C016599 | mono-(2-ethylhexyl)phthalate | Dexamethasone promotes the reaction [[mono-(2-ethylhexyl)phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA] | 18332045 |
| C016599 | mono-(2-ethylhexyl)phthalate | Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [[mono-(2-ethylhexyl)phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]] | 18332045 |
| C016599 | mono-(2-ethylhexyl)phthalate | [mono-(2-ethylhexyl)phthalate co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 18332045 |
| C006429 | monobenzone | [monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D016686 | Monocrotaline | CYP3A4 protein results in increased metabolism of and results in increased activity of Monocrotaline | 19818743 |
| D016686 | Monocrotaline | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | 21224054 |
| D008999 | Monocrotophos | [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein | 22733800 |
| D008999 | Monocrotophos | Monocrotophos results in increased activity of CYP3A4 protein | 22733800 |
| D008999 | Monocrotophos | Monocrotophos results in increased expression of CYP3A4 mRNA | 22733800 |
| D008999 | Monocrotophos | Monocrotophos results in increased expression of CYP3A4 protein | 22733800 |
| D008999 | Monocrotophos | [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein | 22733800 |
| D008999 | Monocrotophos | [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA | 22733800 |
| D008999 | Monocrotophos | [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein | 22733800 |
| C001173 | monoethylglycinexylidide | CYP3A4 protein affects the chemical synthesis of monoethylglycinexylidide | 15887009 |
| C406082 | monomethylarsonous acid | monomethylarsonous acid results in increased expression of CYP3A4 mRNA | 19084030 |
| C517284 | monomethyl phthalate | monomethyl phthalate results in increased expression of CYP3A4 mRNA | 26924002 |
| C050132 | mono-N-demethyladinazolam | CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam | 9600717 |
| C050132 | mono-N-demethyladinazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam] | 9600717 |
| C440780 | mono-N-desethylamiodarone | CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone | 27485346 |
| C440780 | mono-N-desethylamiodarone | [CYP3A4 protein results in increased metabolism of Amiodarone] which results in increased abundance of mono-N-desethylamiodarone | 27485346 |
| C440780 | mono-N-desethylamiodarone | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone] | 27485346 |
| D016293 | Moricizine | Moricizine results in increased expression of CYP3A4 mRNA | 18332078 |
| C437683 | motexafin gadolinium | motexafin gadolinium results in decreased activity of CYP3A4 protein | 17018578 |
| C031021 | muscone | muscone promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| C031021 | muscone | muscone results in increased activity of CYP3A4 protein | 22178124 |
| D009173 | Mycophenolic Acid | CYP3A4 protein results in increased methylation of Mycophenolic Acid | 15570183 |
| D009173 | Mycophenolic Acid | [Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| C005246 | myristicin | CYP3A4 protein affects the oxidation of myristicin | 12523956 |
| C029358 | N-(1-pyrenyl)iodoacetamide | N-(1-pyrenyl)iodoacetamide inhibits the reaction [Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein] | 17497897 |
| C029358 | N-(1-pyrenyl)iodoacetamide | N-(1-pyrenyl)iodoacetamide results in increased alkylation of CYP3A4 protein | 17497897 |
| C451426 | N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide | "[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA" | 25028461 |
| C507425 | N-(4-cyano-benzo(b)thiophene-2-carbonyl)guanidine | CYP3A4 protein results in increased hydroxylation of N-(4-cyano-benzo(b)thiophene-2-carbonyl)guanidine | 16857327 |
| C028473 | N-acetyl-4-benzoquinoneimine | CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine | 24661219 |
| C028473 | N-acetyl-4-benzoquinoneimine | CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine | 24552538 |
| C114289 | N-acetyl-S--(1,2,3,4,4-pentachlorobutadienyl)cysteine sulfoxide | "CYP3A4 protein results in increased abundance of N-acetyl-S--(1,2,3,4,4-pentachlorobutadienyl)cysteine sulfoxide" | 8555406 |
| C049739 | N-acetyl-S-pentachloro-1,3-butadienylcysteine | "CYP3A4 protein results in increased oxidation of N-acetyl-S-pentachloro-1,3-butadienylcysteine" | 8555406 |
| D009254 | Nafcillin | Nafcillin results in increased expression of CYP3A4 mRNA | 18505790 |
| D009254 | Nafcillin | Nafcillin results in increased expression of CYP3A4 protein | 18505790 |
| C031721 | naphthalene | naphthalene results in increased expression of CYP3A4 mRNA | 20500019 |
| C031721 | naphthalene | CYP3A4 protein results in increased activity of naphthalene | 16959878 |
| C005273 | naringenin | naringenin results in decreased activity of CYP3A4 protein | 21053930 |
| C005273 | naringenin | naringenin results in increased expression of CYP3A4 mRNA | 19148864 |
| C005274 | naringin | naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] | 16013069 |
| C005274 | naringin | naringin results in decreased activity of CYP3A4 protein | 16013069|2105393 |
| C005274 | naringin | naringin inhibits the reaction [CYP3A4 protein affects the chemical synthesis of norverapamil] | 16013069 |
| C005274 | naringin | naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] | 16013069 |
| C005274 | naringin | naringin results in decreased activity of CYP3A4 protein | 16013069 |
| C060142 | nateglinide | CYP3A4 protein affects the metabolism of nateglinide | 16042675 |
| C024581 | N-desmethylclobazam | CYP3A4 protein results in increased chemical synthesis of N-desmethylclobazam | 28243904 |
| C024581 | N-desmethylclobazam | [CYP3A4 protein results in increased metabolism of clobazam] which results in increased chemical synthesis of N-desmethylclobazam | 28243904 |
| C079980 | N-desmethyldauricine | [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine | 19358519 |
| C028787 | N-desmethyltamoxifen | CYP3A4 protein results in increased metabolism of N-desmethyltamoxifen | 29285606 |
| C028787 | N-desmethyltamoxifen | "[CYP3A4 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C028787 | N-desmethyltamoxifen | N-desmethyltamoxifen results in decreased activity of CYP3A4 protein | 12419016 |
| C028787 | N-desmethyltamoxifen | [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of N-desmethyltamoxifen | 14652237 |
| C434332 | N-desmethylvenlafaxine | CYP3A4 protein results in increased abundance of N-desmethylvenlafaxine | 21840145 |
| C434332 | N-desmethylvenlafaxine | [CYP3A4 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of N-desmethylvenlafaxine | 21840145 |
| C434332 | N-desmethylvenlafaxine | "[[CYP3A4 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of N-desmethylvenlafaxine] which results in increased abundance of N,O-didesmethylvenlafaxine" | 21840145 |
| C070021 | N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide | "[Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA" | 25028461 |
| C051752 | nefazodone | CYP3A4 protein results in increased hydroxylation of nefazodone | 27485346 |
| C051752 | nefazodone | [CYP3A4 protein results in increased hydroxylation of nefazodone] which results in increased abundance of hydroxynefazodone | 27485346 |
| C051752 | nefazodone | CYP3A4 protein results in increased susceptibility to nefazodone | 21540358 |
| C051752 | nefazodone | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone] | 27485346 |
| C051752 | nefazodone | nefazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| C051752 | nefazodone | nefazodone results in decreased activity of CYP3A4 protein | 21112467|8626361 |
| C057222 | neferine | Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione] | 25451576 |
| C057222 | neferine | Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione] | 25451576 |
| C057222 | neferine | [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione | 25451576 |
| C057222 | neferine | CYP3A4 protein results in increased glutathionylation of neferine metabolite | 25451576 |
| C057222 | neferine | CYP3A4 protein results in increased metabolism of and results in decreased methylation of neferine | 25451576 |
| C057222 | neferine | neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] | 25451576 |
| D019888 | Nelfinavir | Nelfinavir results in decreased activity of CYP3A4 protein | 15523003 |
| C000598690 | N-ethyl-1,2-diphenylethylamine | "CYP3A4 protein results in decreased alkylation of N-ethyl-1,2-diphenylethylamine" | 26276083 |
| C454678 | N-ethyl-3-toluamide | CYP3A4 protein results in increased chemical synthesis of N-ethyl-3-toluamide | 11854147 |
| D019829 | Nevirapine | Nevirapine binds to CYP3A4 protein | 22793666 |
| D009529 | Nicardipine | CYP3A4 protein affects the metabolism of Nicardipine | 15863898 |
| D009529 | Nicardipine | Nicardipine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Triazolam] | 15863898 |
| D009529 | Nicardipine | Nicardipine results in decreased activity of CYP3A4 protein | 10805063|1586065 |
| D009529 | Nicardipine | [Nicardipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D009532 | Nickel | Nickel results in decreased expression of CYP3A4 mRNA | 24768652 |
| D009534 | Niclosamide | Niclosamide results in decreased activity of CYP3A4 protein | 11124226 |
| D009538 | Nicotine | [Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | 12851153|1285115 |
| D009543 | Nifedipine | "6',7'-dihydroxybergamottin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]" | 23146034 |
| D009543 | Nifedipine | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]] | 25069801 |
| D009543 | Nifedipine | Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine] | 18846481 |
| D009543 | Nifedipine | CYP3A4 protein affects the metabolism of Nifedipine | 15286053|1563494 |
| D009543 | Nifedipine | CYP3A4 protein affects the oxidation of Nifedipine | 2271712 |
| D009543 | Nifedipine | CYP3A4 protein results in increased hydroxylation of Nifedipine | 18846481 |
| D009543 | Nifedipine | CYP3A4 protein results in increased metabolism of Nifedipine | 16712844|1923059 |
| D009543 | Nifedipine | CYP3A4 protein results in increased oxidation of Nifedipine | 15618748|1593756 |
| D009543 | Nifedipine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine] | 18846481 |
| D009543 | Nifedipine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine] | 20863320|2314603 |
| D009543 | Nifedipine | [Nifedipine binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA | 12851153|1285115 |
| D009543 | Nifedipine | Nifedipine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D009543 | Nifedipine | [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D009543 | Nifedipine | Nifedipine results in increased expression of CYP3A4 mRNA | 16837568|1795452 |
| D009543 | Nifedipine | Nifedipine results in increased expression of CYP3A4 protein | 22524704 |
| D009543 | Nifedipine | NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA] | 25069801 |
| D009543 | Nifedipine | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine] | 20863320 |
| D009543 | Nifedipine | YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Nifedipine] | 19230594 |
| D009543 | Nifedipine | Nifedipine results in decreased activity of CYP3A4 protein | 18420780 |
| D009543 | Nifedipine | Nifedipine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D009543 | Nifedipine | [SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine | 19501153 |
| D009543 | Nifedipine | CYP3A4 protein results in increased metabolism of Nifedipine | 11231118 |
| C012655 | nimesulide | CYP3A4 protein results in increased glutathionylation of nimesulide | 26524229 |
| C002714 | nimetazepam | CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] | 19005028 |
| C002714 | nimetazepam | CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] | 19005028 |
| C002714 | nimetazepam | CYP3A4 protein results in increased metabolism of and results in increased activity of nimetazepam | 19005028 |
| D009553 | Nimodipine | Carbamazepine affects the reaction [CYP3A4 protein results in increased metabolism of Nimodipine] | 16269628 |
| D009553 | Nimodipine | CYP3A4 protein results in increased metabolism of Nimodipine | 16269628 |
| D009553 | Nimodipine | Phenobarbital affects the reaction [CYP3A4 protein results in increased metabolism of Nimodipine] | 16269628 |
| D009553 | Nimodipine | Phenytoin affects the reaction [CYP3A4 protein results in increased metabolism of Nimodipine] | 16269628 |
| C000598691 | N-isopropyl-1,2-diphenylethylamine | "CYP3A4 protein results in decreased alkylation of N-isopropyl-1,2-diphenylethylamine" | 26276083 |
| D009567 | Nitrazepam | CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein] | 19005028 |
| D009567 | Nitrazepam | CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein] | 19005028 |
| D009567 | Nitrazepam | CYP3A4 protein results in increased metabolism of and results in increased activity of Nitrazepam | 19005028 |
| D009568 | Nitrendipine | CYP3A4 protein affects the metabolism of Nitrendipine | 15286053 |
| C051570 | N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine | "CYP3A4 protein results in increased metabolism of and results in decreased methylation of N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine metabolite" | 19576971 |
| C041150 | N-methyl-7H-dibenzo(c,g)carbazole | "CYP3A4 protein results in increased metabolism of N-methyl-7H-dibenzo(c,g)carbazole" | 21798277 |
| C041150 | N-methyl-7H-dibenzo(c,g)carbazole | "[CYP3A4 protein results in increased metabolism of N-methyl-7H-dibenzo(c,g)carbazole] which results in increased mutagenesis of HPRT1 exon" | 21798277 |
| C574385 | N,N-didesmethyl-4-hydroxytamoxifen | "CYP3A4 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen" | 29285606 |
| C574385 | N,N-didesmethyl-4-hydroxytamoxifen | "[CYP3A4 protein results in increased metabolism of N,N-didesmethyl-4-hydroxytamoxifen] which results in increased abundance of N,N-didesmethyl-4-hydroxytamoxifen" | 29285606 |
| C122072 | N,N-didesmethyltamoxifen | "CYP3A4 protein results in increased metabolism of N,N-didesmethyltamoxifen" | 29285606 |
| C122072 | N,N-didesmethyltamoxifen | "[CYP3A4 protein results in increased metabolism of N,N-didesmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| C081306 | N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide | "N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide results in increased expression of CYP3A4 mRNA" | 21315811 |
| C010257 | N'-nitrosoanabasine | CYP3A4 protein affects the metabolism of and results in increased activity of N'-nitrosoanabasine | 11774366 |
| C013161 | N-nitroso(di-n-propyl)amine | CYP3A4 protein affects the metabolism of N-nitroso(di-n-propyl)amine | 10910959 |
| C013161 | N-nitroso(di-n-propyl)amine | CYP3A4 protein results in decreased nitrosation of N-nitroso(di-n-propyl)amine | 10910959 |
| C093285 | NOC 18 | NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] | 18206661 |
| C434333 | N,O-didesmethylvenlafaxine | "[[CYP3A4 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of N-desmethylvenlafaxine] which results in increased abundance of N,O-didesmethylvenlafaxine" | 21840145 |
| C001870 | nonachlor | nonachlor results in increased expression of CYP3A4 protein | 15548381 |
| C043585 | norbuprenorphine | CYP3A4 protein affects the chemical synthesis of norbuprenorphine | 15966752 |
| C043585 | norbuprenorphine | norbuprenorphine results in decreased activity of CYP3A4 protein | 12756210 |
| C072044 | norcisapride | CYP3A4 protein affects the chemical synthesis of norcisapride | 11717173 |
| C072044 | norcisapride | CYP3A4 protein affects the metabolism of norcisapride | 11717173 |
| C058272 | norclozapine | CYP3A4 protein results in increased chemical synthesis of norclozapine | 18809730 |
| C058272 | norclozapine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine] | 18809730 |
| C010414 | norcodeine | [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine | 16595712 |
| D003708 | Nordazepam | CYP3A4 protein results in increased metabolism of Nordazepam | 18846481 |
| C036139 | norfluoxetine | norfluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| C010262 | norharman | CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] | 15279827 |
| C054116 | norlevorphanol | [CYP3A4 protein results in increased metabolism of Dextrorphan] which results in increased chemical synthesis of norlevorphanol | 21606622 |
| C077256 | noroxycodone | telithromycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of noroxycodone] | 19755414 |
| C077256 | noroxycodone | CYP3A4 protein results in increased chemical synthesis of noroxycodone | 19755414 |
| D009661 | Nortriptyline | Nortriptyline results in increased metabolism of CYP3A4 protein | 18359012 |
| C016904 | norverapamil | CYP3A4 protein affects the chemical synthesis of norverapamil | 16013069 |
| C016904 | norverapamil | naringin inhibits the reaction [CYP3A4 protein affects the chemical synthesis of norverapamil] | 16013069 |
| C016904 | norverapamil | CYP3A4 protein affects the chemical synthesis of norverapamil | 15905061 |
| C072936 | notoginsenoside R1 | notoginsenoside R1 results in increased expression of CYP3A4 mRNA | 25472953 |
| C464660 | obeticholic acid | obeticholic acid inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 27939613 |
| C464660 | obeticholic acid | obeticholic acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | 27939613 |
| C464660 | obeticholic acid | obeticholic acid results in decreased activity of CYP3A4 protein | 27939613 |
| C464660 | obeticholic acid | obeticholic acid results in decreased expression of CYP3A4 mRNA | 27939613 |
| C025589 | ochratoxin A | CYP3A4 protein results in increased susceptibility to ochratoxin A | 21781659|8542584 |
| C025589 | ochratoxin A | ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 26341324 |
| C025589 | ochratoxin A | ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 26341324 |
| C025589 | ochratoxin A | ochratoxin A results in decreased expression of CYP3A4 mRNA | 26505656 |
| C025589 | ochratoxin A | ochratoxin A results in increased expression of CYP3A4 mRNA | 21834667 |
| D019787 | Linoleic Acid | Linoleic Acid results in decreased activity of CYP3A4 protein | 16978661 |
| D019301 | Oleic Acid | Oleic Acid results in decreased expression of CYP3A4 protein | 26739624 |
| D015242 | Ofloxacin | [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] | 11408986 |
| D019319 | Okadaic Acid | CYP3A4 protein results in decreased susceptibility to Okadaic Acid | 24504163 |
| D019319 | Okadaic Acid | CYP3A4 protein results in increased metabolism of and results in increased hydroxylation of and results in decreased susceptibility to Okadaic Acid | 26374342 |
| D009828 | Oleanolic Acid | Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 15043991 |
| D009828 | Oleanolic Acid | Oleanolic Acid results in decreased activity of CYP3A4 protein | 15043991 |
| C026209 | oltipraz | oltipraz affects the activity of CYP3A4 protein | 10775323 |
| C026209 | oltipraz | oltipraz metabolite results in decreased activity of CYP3A4 protein | 10775323 |
| C026209 | oltipraz | oltipraz results in decreased activity of CYP3A4 protein | 19833192 |
| D009853 | Omeprazole | CYP3A4 protein affects the metabolism of Omeprazole | 15286053|1562658 |
| D009853 | Omeprazole | CYP3A4 protein results in increased metabolism of Omeprazole | 12485723|1756571 |
| D009853 | Omeprazole | NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA] | 12695340 |
| D009853 | Omeprazole | Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D009853 | Omeprazole | [Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D009853 | Omeprazole | Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein | 15802389 |
| D009853 | Omeprazole | Omeprazole results in increased expression of CYP3A4 mRNA | 12235278|1269534 |
| D009853 | Omeprazole | Omeprazole results in increased expression of CYP3A4 protein | 9744552 |
| D009853 | Omeprazole | Omeprazole results in decreased activity of CYP3A4 protein | 18420780 |
| D009853 | Omeprazole | Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D009853 | Omeprazole | Omeprazole results in decreased activity of CYP3A4 protein | 16988209 |
| C040449 | omeprazole sulfide | CYP3A4 protein results in increased metabolism of omeprazole sulfide | 16109480 |
| C002771 | Omite | "[Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA" | 25028461 |
| D017294 | Ondansetron | CYP3A4 protein affects the metabolism of Ondansetron | 15286053 |
| C009618 | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | "CYP3A4 results in increased chemical synthesis of O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate" | 20709133 |
| C016340 | o,p'-DDT | "Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]" | 15795092 |
| C016340 | o,p'-DDT | "o,p'-DDT results in increased activity of CYP3A4 protein" | 17035600 |
| C016340 | o,p'-DDT | "o,p'-DDT results in increased expression of CYP3A4 mRNA" | 15795092|1703560 |
| C016340 | o,p'-DDT | "o,p'-DDT results in increased expression of CYP3A4 protein" | 15548381|1579509 |
| D009943 | Organophosphorus Compounds | Organophosphorus Compounds inhibits the reaction [CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine] | 15922009 |
| D009943 | Organophosphorus Compounds | Organophosphorus Compounds results in decreased activity of CYP3A4 protein | 17936932 |
| C055122 | orlistat | orlistat results in increased expression of CYP3A4 mRNA | 20599501 |
| C055122 | orlistat | orlistat results in increased expression of CYP3A4 protein | 20599501 |
| D008939 | Mitotane | Mitotane promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 23179081 |
| D008939 | Mitotane | Mitotane results in increased activity of CYP3A4 protein | 23179081 |
| D008939 | Mitotane | Mitotane results in increased expression of CYP3A4 mRNA | 23179081 |
| D008939 | Mitotane | NR1I2 protein promotes the reaction [Mitotane results in increased expression of CYP3A4 mRNA] | 23179081 |
| D008939 | Mitotane | Mitotane results in decreased activity of CYP3A4 protein | 25542188 |
| D008939 | Mitotane | Mitotane results in increased expression of CYP3A4 mRNA | 25542188 |
| C012466 | oxadiazon | oxadiazon results in increased expression of CYP3A4 mRNA | 16565514 |
| C015408 | oxatomide | CYP3A4 protein results in increased metabolism of oxatomide | 15684493 |
| C015408 | oxatomide | oxatomide results in decreased activity of CYP3A4 protein | 15684493 |
| C036006 | oxcarbazepine | oxcarbazepine results in increased activity of CYP3A4 protein | 12895138|1473106 |
| C022155 | oxiconazole | NR1I2 promotes the reaction [oxiconazole results in increased expression of CYP3A4 protein] | 17998298 |
| C022155 | oxiconazole | oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]] | 17998298 |
| C022155 | oxiconazole | oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] | 17998298 |
| C022155 | oxiconazole | oxiconazole results in increased expression of CYP3A4 mRNA | 17998298 |
| D010098 | Oxycodone | telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone] | 19755414 |
| D010098 | Oxycodone | CYP3A4 protein results in decreased methylation of Oxycodone | 19755414 |
| D010100 | Oxygen | "[[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene" | 21766881 |
| D010100 | Oxygen | [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal | 21766881 |
| D010100 | Oxygen | CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA] | 21566342 |
| D010100 | Oxygen | CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] | 21566342 |
| D010100 | Oxygen | Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]] | 21566342 |
| D010100 | Oxygen | Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]] | 21566342 |
| D010100 | Oxygen | Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Paclitaxel] | 19695866 |
| D010100 | Oxygen | Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 19695866 |
| D010100 | Oxygen | Oxygen deficiency results in decreased expression of and results in decreased activity of CYP3A4 protein | 19695866 |
| D010100 | Oxygen | Oxygen deficiency results in decreased expression of CYP3A4 mRNA | 19695866 |
| D017239 | Paclitaxel | CYP3A4 protein affects the metabolism of Paclitaxel | 15901749 |
| D017239 | Paclitaxel | CYP3A4 protein results in increased hydroxylation of Paclitaxel | 19695866 |
| D017239 | Paclitaxel | CYP3A4 protein results in increased oxidation of Paclitaxel | 12237780 |
| D017239 | Paclitaxel | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel] | 12237780 |
| D017239 | Paclitaxel | Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA] | 16819505|1743810 |
| D017239 | Paclitaxel | Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein] | 16819505 |
| D017239 | Paclitaxel | Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Paclitaxel] | 19695866 |
| D017239 | Paclitaxel | Paclitaxel results in decreased activity of CYP3A4 protein | 19909766 |
| D017239 | Paclitaxel | Paclitaxel results in increased activity of CYP3A4 protein | 12065438|1883917 |
| D017239 | Paclitaxel | Paclitaxel results in increased expression of CYP3A4 mRNA | 15650019|1681950 |
| D017239 | Paclitaxel | Paclitaxel results in increased expression of CYP3A4 protein | 15650019|1681950 |
| D017239 | Paclitaxel | Paclitaxel results in increased expression of CYP3A4 protein | 15918522 |
| D017239 | Paclitaxel | Plant Extracts inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein] | 15918522 |
| C064276 | pantoprazole | CYP3A4 protein results in increased metabolism of pantoprazole | 8930576 |
| C064276 | pantoprazole | pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 15258107 |
| C064276 | pantoprazole | pantoprazole results in increased expression of CYP3A4 protein | 9744552 |
| D010278 | Parathion | CYP3A4 protein affects the metabolism of Parathion | 12669189|1707935 |
| D010278 | Parathion | Parathion results in increased expression of CYP3A4 mRNA | 26196221 |
| D010278 | Parathion | Parathion results in increased expression of CYP3A4 protein | 26196221 |
| C084656 | paricalcitol | paricalcitol results in increased expression of CYP3A4 mRNA | 11723248 |
| C506614 | PD 0325901 | PD 0325901 results in increased expression of CYP3A4 mRNA | 24819614 |
| C419982 | PD 180988 | PD 180988 results in decreased activity of CYP3A4 protein | 23721565 |
| C419982 | PD 180988 | PD 180988 results in increased expression of CYP3A4 mRNA | 23721565 |
| C087058 | penconazole | "[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA" | 25028461 |
| D010404 | Penicillin V | Penicillin V results in increased expression of CYP3A4 mRNA | 18505790 |
| D010404 | Penicillin V | Penicillin V results in increased expression of CYP3A4 protein | 18505790 |
| C086401 | pentabromodiphenyl ether | pentabromodiphenyl ether results in increased expression of CYP3A4 mRNA | 19270788 |
| C003060 | pentachlorobenzene | CYP3A4 protein results in increased oxidation of pentachlorobenzene | 7747284 |
| D010416 | Pentachlorophenol | Pentachlorophenol results in increased expression of CYP3A4 protein | 15548381 |
| D010419 | Pentamidine | Pentamidine results in decreased activity of CYP3A4 protein | 11124226 |
| D010464 | Perazine | CYP3A4 protein results in decreased methylation of Perazine | 11026737 |
| C036567 | perfluorodecanoic acid | perfluorodecanoic acid results in increased expression of CYP3A4 mRNA | 23567314 |
| C522391 | perfluorododecanoic acid | perfluorododecanoic acid results in decreased expression of CYP3A4 mRNA | 23567314 |
| C471071 | perfluorohexanesulfonic acid | perfluorohexanesulfonic acid results in increased expression of CYP3A4 mRNA | 23567314 |
| C101815 | perfluoro-n-heptanoic acid | perfluoro-n-heptanoic acid results in increased expression of CYP3A4 mRNA | 23567314 |
| C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid inhibits the reaction [CYP3A4 protein results in increased oxidation of Testosterone] | 21964418 |
| C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid results in increased expression of CYP3A4 mRNA | 21723365|2356731 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in increased expression of CYP3A4 mRNA | 23567314 |
| D026023 | Permethrin | CYP3A4 protein results in increased metabolism of Permethrin | 24548679 |
| D026023 | Permethrin | Permethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] | 16790556 |
| D026023 | Permethrin | Permethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] | 16790556 |
| D026023 | Permethrin | Permethrin results in decreased activity of CYP3A4 protein | 16790556|2192425 |
| D026023 | Permethrin | Permethrin results in increased expression of CYP3A4 mRNA | 19249324|1932676 |
| D010575 | Pesticides | Pesticides results in decreased activity of CYP3A4 protein | 17936932 |
| C569762 | PF 03715455 | PF 03715455 results in decreased activity of CYP3A4 protein | 21888439 |
| D010622 | Phencyclidine | CYP3A4 protein affects the metabolism of Phencyclidine | 16782764 |
| D010624 | Phenelzine | Phenelzine results in decreased activity of CYP3A4 protein | 15304522 |
| C058305 | phenethyl isothiocyanate | phenethyl isothiocyanate results in decreased activity of CYP3A4 mRNA | 20442190 |
| C058305 | phenethyl isothiocyanate | phenethyl isothiocyanate results in decreased expression of CYP3A4 mRNA | 20442190 |
| C058305 | phenethyl isothiocyanate | phenethyl isothiocyanate results in increased expression of CYP3A4 protein | 20025923 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of CYP3A4 mRNA | 19952500 |
| D010634 | Phenobarbital | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 24224465 |
| D010634 | Phenobarbital | [Celsior co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA | 15448115 |
| D010634 | Phenobarbital | Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 16608920 |
| D010634 | Phenobarbital | lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 24224465 |
| D010634 | Phenobarbital | [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA | 24999631 |
| D010634 | Phenobarbital | NR1I2 protein affects the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 12695340 |
| D010634 | Phenobarbital | NR3C1 protein promotes the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 10219967 |
| D010634 | Phenobarbital | Phenobarbital affects the expression of CYP3A4 mRNA | 19159669 |
| D010634 | Phenobarbital | Phenobarbital results in decreased activity of CYP3A4 protein | 19909766 |
| D010634 | Phenobarbital | Phenobarbital results in increased activity of CYP3A4 mRNA | 19202563 |
| D010634 | Phenobarbital | Phenobarbital results in increased activity of CYP3A4 protein | 12065438|1497787 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of and results in increased activity of CYP3A4 protein | 15802389|1583392 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of CYP3A4 mRNA | 10219967|1250531 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of CYP3A4 mRNA alternative form | 21998292 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of CYP3A4 protein | 10640517|1258415 |
| D010634 | Phenobarbital | [Phenobarbital results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D010634 | Phenobarbital | sodium arsenite inhibits the reaction [Phenobarbital results in increased expression of and results in increased activity of CYP3A4 protein] | 15833926 |
| D010634 | Phenobarbital | sodium arsenite inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 15833926 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of CYP3A4 mRNA | 19136022 |
| D010634 | Phenobarbital | Phenobarbital affects the reaction [CYP3A4 protein results in increased metabolism of Nimodipine] | 16269628 |
| C033457 | phenobarbital quinidine | IL1B protein inhibits the reaction [phenobarbital quinidine results in increased expression of CYP3A4 mRNA] | 15382119 |
| C033457 | phenobarbital quinidine | phenobarbital quinidine results in increased expression of CYP3A4 mRNA | 15382119 |
| C008838 | phenthoate | phenthoate results in decreased activity of CYP3A4 protein | 20183062 |
| C008838 | phenthoate | phenthoate results in increased activity of CYP3A4 protein | 22310298 |
| C008838 | phenthoate | phenthoate results in increased expression of CYP3A4 mRNA | 22310298 |
| D010653 | Phenylbutazone | NR3C1 protein promotes the reaction [Phenylbutazone results in increased expression of CYP3A4 mRNA] | 10219967 |
| D010653 | Phenylbutazone | Phenylbutazone results in increased activity of CYP3A4 protein | 9512926 |
| D010653 | Phenylbutazone | Phenylbutazone results in increased expression of CYP3A4 mRNA | 10219967 |
| D010672 | Phenytoin | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin | 23397584 |
| D010672 | Phenytoin | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D010672 | Phenytoin | NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] | 18206661 |
| D010672 | Phenytoin | NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] | 12695340 |
| D010672 | Phenytoin | NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] | 10219967 |
| D010672 | Phenytoin | Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | 16207822 |
| D010672 | Phenytoin | Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21402137 |
| D010672 | Phenytoin | Phenytoin results in increased activity of CYP3A4 protein | 12065438|1497787 |
| D010672 | Phenytoin | Phenytoin results in increased expression of CYP3A4 mRNA | 10219967|1250531 |
| D010672 | Phenytoin | Phenytoin results in increased expression of CYP3A4 protein | 18206661 |
| D010672 | Phenytoin | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | 21224054 |
| D010672 | Phenytoin | Phenytoin affects the reaction [CYP3A4 protein results in increased metabolism of Nimodipine] | 16269628 |
| C085059 | phloxine | phloxine results in decreased activity of CYP3A4 protein | 20041016 |
| C003117 | phosalone | "[Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA" | 25028461 |
| D010718 | Phosphatidylserines | "[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein" | 1627548 |
| C032279 | phthalic acid | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid | 22186153|2354548 |
| C032279 | phthalic acid | phthalic acid results in increased expression of CYP3A4 mRNA | 15650019 |
| C032279 | phthalic acid | phthalic acid results in increased expression of CYP3A4 protein | 15650019 |
| C041648 | pimobendan | CYP3A4 protein results in decreased methylation of pimobendan | 10611143 |
| C060836 | pioglitazone | CYP3A4 protein affects the metabolism of pioglitazone | 15900286 |
| C060836 | pioglitazone | pioglitazone results in decreased activity of CYP3A4 protein | 12642470|1586065 |
| C060836 | pioglitazone | pioglitazone results in increased expression of and results in increased activity of CYP3A4 protein | 12642470 |
| C060836 | pioglitazone | pioglitazone results in increased expression of CYP3A4 mRNA | 12642470|1683756 |
| C060836 | pioglitazone | pioglitazone results in increased expression of CYP3A4 protein | 22524704 |
| C060836 | pioglitazone | [pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| C060836 | pioglitazone | [pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| C008922 | piperine | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]] | 23707768 |
| C008922 | piperine | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]] | 23707768 |
| C008922 | piperine | NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA] | 23707768 |
| C008922 | piperine | NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein] | 23707768 |
| C008922 | piperine | [piperine co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 23707768 |
| C008922 | piperine | piperine results in increased expression of CYP3A4 mRNA | 23707768 |
| C008922 | piperine | piperine results in increased expression of CYP3A4 protein | 23707768 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A4 mRNA | 19710929 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of CYP3A4 mRNA | 27551952 |
| C037850 | PK 11195 | PK 11195 results in increased expression of CYP3A4 mRNA | 21315811 |
| D010936 | Plant Extracts | NR1I2 protein affects the reaction [Plant Extracts results in increased expression of CYP3A4 mRNA] | 12695340 |
| D010936 | Plant Extracts | Plant Extracts affects the expression of CYP3A4 mRNA | 24446304 |
| D010936 | Plant Extracts | Plant Extracts results in decreased activity of CYP3A4 protein | 15627040|1590028 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of CYP3A4 mRNA | 19041297 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of CYP3A4 protein | 19041297 |
| D010936 | Plant Extracts | Plant Extracts results in increased activity of CYP3A4 protein | 15025748|1597464 |
| D010936 | Plant Extracts | Plant Extracts results in increased expression of CYP3A4 mRNA | 12695340|1721044 |
| D010936 | Plant Extracts | Plant Extracts inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein] | 15918522 |
| D010936 | Plant Extracts | Plant Extracts results in decreased activity of CYP3A4 protein | 16033948 |
| D010936 | Plant Extracts | Plant Extracts results in decreased activity of CYP3A4 protein | 9550749 |
| D010936 | Plant Extracts | [Plant Extracts results in decreased activity of CYP3A4 protein] which results in increased abundance of Terfenadine | 9550749 |
| D028321 | Plant Preparations | Plant Preparations analog results in increased expression of CYP3A4 mRNA | 19148864 |
| D028321 | Plant Preparations | Plant Preparations results in decreased activity of CYP3A4 protein | 15937564|2653062 |
| D028321 | Plant Preparations | Plant Preparations results in decreased expression of CYP3A4 mRNA | 26530625 |
| D028321 | Plant Preparations | Plant Preparations results in decreased activity of CYP3A4 protein | 19148864 |
| C013649 | plastochromanol 8 | plastochromanol 8 results in increased expression of CYP3A4 | 15269186|1600810 |
| C013649 | plastochromanol 8 | plastochromanol 8 results in increased expression of CYP3A4 mRNA | 15649653 |
| C008937 | platyphylline | CYP3A4 protein results in increased metabolism of platyphylline | 24308637 |
| D011078 | Polychlorinated Biphenyls | Polychlorinated Biphenyls results in increased activity of CYP3A4 protein | 17692354 |
| C467566 | pomalidomide | CYP3A4 protein results in increased oxidation of pomalidomide | 24350712 |
| C101425 | posaconazole | posaconazole results in decreased activity of CYP3A4 protein | 19346885 |
| C028033 | potassium ferricyanide | potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]] | 22652334 |
| C028033 | potassium ferricyanide | potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]] | 22652334 |
| C028033 | potassium ferricyanide | potassium ferricyanide inhibits the reaction [Diltiazem results in decreased activity of CYP3A4 protein] | 22652334 |
| C028033 | potassium ferricyanide | potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]] | 22652334 |
| C028033 | potassium ferricyanide | potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]] | 22652334 |
| C072212 | PR 39 | PR 39 results in increased activity of CYP3A4 protein | 12388057 |
| C482452 | pramiconazole | pramiconazole results in decreased activity of CYP3A4 protein | 15328084 |
| D017035 | Pravastatin | CYP3A4 protein results in increased metabolism of Pravastatin | 18440347 |
| D011223 | Praziquantel | CYP3A4 protein affects the metabolism of Praziquantel | 12920490 |
| D011239 | Prednisolone | Prednisolone results in increased expression of CYP3A4 mRNA | 12673034 |
| C023617 | pregna-4,17-diene-3,16-dione | "pregna-4,17-diene-3,16-dione results in increased expression of CYP3A4 mRNA" | 15075359 |
| D011284 | Pregnenolone | Pregnenolone results in increased expression of CYP3A4 mRNA | 15650019 |
| D011284 | Pregnenolone | Pregnenolone results in increased expression of CYP3A4 protein | 15650019 |
| D011285 | Pregnenolone Carbonitrile | NR1I2 gene promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A4 protein] | 18799805 |
| D011285 | Pregnenolone Carbonitrile | NR3C1 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA] | 10219967 |
| D011285 | Pregnenolone Carbonitrile | [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25542144 |
| D011285 | Pregnenolone Carbonitrile | Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA | 10219967|1250531 |
| D011285 | Pregnenolone Carbonitrile | Pregnenolone Carbonitrile results in increased expression of CYP3A4 protein | 18799805 |
| D011285 | Pregnenolone Carbonitrile | [Pregnenolone Carbonitrile co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 23707768 |
| D011285 | Pregnenolone Carbonitrile | allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D011285 | Pregnenolone Carbonitrile | [NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA | 25069801 |
| C118050 | pretilachlor | pretilachlor results in increased expression of CYP3A4 mRNA | 16565514 |
| D011319 | Primaquine | [CYP3A4 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine | 19616568 |
| D011319 | Primaquine | CYP3A4 protein results in increased metabolism of Primaquine | 19616568 |
| D011335 | Proadifen | [Proadifen co-treated with Cisplatin] results in decreased expression of CYP3A4 protein | 26721606 |
| D011335 | Proadifen | Proadifen results in decreased expression of CYP3A4 protein | 26721606 |
| D011335 | Proadifen | Proadifen results in decreased activity of CYP3A4 protein | 12388057 |
| D011339 | Probenecid | Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide] | 15915352 |
| D011339 | Probenecid | Probenecid promotes the reaction [CYP3A4 protein affects the metabolism of Carbamazepine] | 15915352 |
| D011339 | Probenecid | Probenecid results in decreased expression of CYP3A4 mRNA | 16837568 |
| C035988 | procymidone | [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA | 25028461 |
| C024273 | profenofos | CYP3A4 protein results in increased metabolism of profenofos | 23415833 |
| C024273 | profenofos | [CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol | 23415833 |
| C024273 | profenofos | profenofos results in increased activity of CYP3A4 protein | 22310298 |
| C024273 | profenofos | profenofos results in increased expression of CYP3A4 mRNA | 22310298 |
| D011374 | Progesterone | Progesterone results in increased expression of CYP3A4 mRNA | 20631399 |
| D011374 | Progesterone | CYP3A4 protein results in increased hydroxylation of Progesterone | 18957504 |
| D011374 | Progesterone | Progesterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D011374 | Progesterone | Progesterone results in increased expression of CYP3A4 mRNA | 22837389 |
| D011374 | Progesterone | Progesterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D002727 | Proguanil | Proguanil results in decreased activity of CYP3A4 protein | 11124226 |
| C001059 | pronamide | pronamide results in increased expression of CYP3A4 mRNA | 17293382 |
| C045950 | propiconazole | propiconazole results in decreased activity of CYP3A4 protein | 29420809 |
| C045950 | propiconazole | [propiconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 29420809 |
| D011433 | Propranolol | CYP3A4 protein results in increased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | CYP3A4 protein results in increased oxidation of Propranolol | 19853591 |
| D011433 | Propranolol | CYP3A4 protein results in increased oxidation of Propranolol | 19853591 |
| D011715 | Pyrantel | Pyrantel results in decreased activity of CYP3A4 protein | 11124226 |
| C432165 | pyrazolanthrone | pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 17965521 |
| C030984 | pyrene | CYP3A4 protein affects the metabolism of pyrene | 15910734 |
| C030984 | pyrene | CYP3A4 protein results in increased oxidation of pyrene | 10997940 |
| C030984 | pyrene | Magnesium Chloride affects the reaction [CYP3A4 protein results in increased oxidation of pyrene] | 10997940 |
| C030984 | pyrene | Testosterone affects the reaction [CYP3A4 protein affects the metabolism of pyrene] | 15910734 |
| D011722 | Pyrethrins | Pyrethrins results in increased expression of CYP3A4 mRNA | 18022748 |
| C023666 | pyridine | CYP3A4 protein results in increased chemical synthesis of pyridine | 10805063 |
| C108337 | pyrimethanil | "[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA" | 25028461 |
| D011744 | Pyrimidinones | CYP3A4 protein results in increased oxidation of and results in increased glutathionylation of Pyrimidinones | 20507089 |
| D011763 | Pyrrolizidine Alkaloids | Pyrrolizidine Alkaloids results in increased expression of CYP3A4 mRNA | 26100227 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | 19766177 |
| D011794 | Quercetin | Quercetin inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] | 15266218 |
| D011794 | Quercetin | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D011794 | Quercetin | Quercetin results in decreased activity of CYP3A4 protein | 15266218|1842078 |
| D011794 | Quercetin | [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine | 11502731 |
| D011794 | Quercetin | Quercetin results in increased expression of CYP3A4 mRNA | 12695340|1526621 |
| D011794 | Quercetin | Quercetin results in increased expression of CYP3A4 protein | 26366751 |
| D011794 | Quercetin | VDR promotes the reaction [Quercetin results in increased expression of CYP3A4 mRNA] | 26366751 |
| D000069348 | Quetiapine Fumarate | Carbamazepine promotes the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate] | 16390352 |
| D000069348 | Quetiapine Fumarate | CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate | 16390352 |
| D000069348 | Quetiapine Fumarate | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate] | 16390352 |
| D000069348 | Quetiapine Fumarate | CYP3A4 protein affects the metabolism of Quetiapine Fumarate | 17632227 |
| D011796 | Quinacrine | CYP3A4 protein results in increased metabolism of Quinacrine | 16581945 |
| D011802 | Quinidine | CYP3A4 protein affects the metabolism of Quinidine | 15784650|2271712 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758] | 19230594 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D011802 | Quinidine | Quinidine results in decreased activity of CYP3A4 protein | 18420780 |
| D011802 | Quinidine | Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D011802 | Quinidine | Ciprofloxacin inhibits the reaction [CYP3A4 protein results in increased metabolism of Quinidine] | 15869686 |
| D011802 | Quinidine | CYP3A4 protein results in increased metabolism of Quinidine | 15869686 |
| D011802 | Quinidine | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Quinidine] | 15869686 |
| D011802 | Quinidine | Quinidine results in decreased activity of CYP3A4 protein | 11274899 |
| D011803 | Quinine | CYP3A4 protein affects the metabolism of Quinine | 12920490|1589624 |
| D011803 | Quinine | Quinine results in decreased activity of CYP3A4 protein | 11124226 |
| C068040 | quinone methide | [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of quinone methide | 19358519 |
| C470613 | quinoxyfen | "[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA" | 25028461 |
| C450682 | R116010 | R116010 results in decreased activity of CYP3A4 protein | 21428449 |
| C450682 | R116010 | R116010 results in decreased activity of CYP3A4 protein | 21838328 |
| C523099 | rabeprazole-thioether | rabeprazole-thioether inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 15258107 |
| D020849 | Raloxifene Hydrochloride | Raloxifene Hydrochloride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D020849 | Raloxifene Hydrochloride | Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein | 15860655|2372156 |
| D020849 | Raloxifene Hydrochloride | Raloxifene Hydrochloride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D020849 | Raloxifene Hydrochloride | [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of Raloxifene Hydrochloride | 22429462 |
| D020849 | Raloxifene Hydrochloride | CYP3A4 protein results in increased activity of Raloxifene Hydrochloride | 16959878 |
| D020849 | Raloxifene Hydrochloride | Iodoacetamide inhibits the reaction [Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein] | 17497897 |
| D020849 | Raloxifene Hydrochloride | N-(1-pyrenyl)iodoacetamide inhibits the reaction [Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein] | 17497897 |
| D020849 | Raloxifene Hydrochloride | Raloxifene Hydrochloride binds to and results in increased alkylation of and results in decreased activity of CYP3A4 protein | 17497897 |
| C495910 | ramelteon | CYP3A4 protein results in increased metabolism of ramelteon | 17069551 |
| D017382 | Reactive Oxygen Species | CAT protein inhibits the reaction [CYP3A4 protein results in increased abundance of Reactive Oxygen Species] | 21566342 |
| D017382 | Reactive Oxygen Species | CYP3A4 protein results in increased abundance of Reactive Oxygen Species | 21566342 |
| D000548 | Amaranth Dye | Amaranth Dye results in decreased activity of CYP3A4 protein | 20041016 |
| C072379 | repaglinide | CYP3A4 protein affects the metabolism of repaglinide | 16042675 |
| D012110 | Reserpine | [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D012110 | Reserpine | Reserpine results in increased expression of CYP3A4 mRNA | 16837568 |
| D012110 | Reserpine | Reserpine results in increased expression of CYP3A4 protein | 8632764 |
| C059514 | resveratrol | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Buspirone] | 20716633 |
| C059514 | resveratrol | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | 12569440 |
| C059514 | resveratrol | resveratrol results in decreased activity of CYP3A4 protein | 12569440|1842078 |
| C059514 | resveratrol | [resveratrol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 21524698 |
| C059514 | resveratrol | resveratrol results in increased expression of CYP3A4 mRNA | 17210444 |
| D015474 | Isotretinoin | Isotretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| D015474 | Isotretinoin | Isotretinoin results in increased activity of CYP3A4 protein | 16632523 |
| D015474 | Isotretinoin | [Isotretinoin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D015474 | Isotretinoin | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[Isotretinoin co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| D015474 | Isotretinoin | [Isotretinoin co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA | 19686701 |
| D015474 | Isotretinoin | "Isotretinoin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]" | 19686701 |
| D015474 | Isotretinoin | Isotretinoin promotes the reaction [[RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| D015474 | Isotretinoin | Isotretinoin promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C014794 | retinol palmitate | retinol palmitate promotes the reaction [[RXRA protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C014794 | retinol palmitate | retinol palmitate promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA] | 19686701 |
| C003300 | retrorsine | CYP3A4 protein results in increased metabolism of and results in increased activity of retrorsine | 19818743 |
| C003300 | retrorsine | CYP3A4 protein results in increased susceptibility to retrorsine | 24799337 |
| C003300 | retrorsine | Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein] | 19818743 |
| C003300 | retrorsine | [retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein | 19818743 |
| C003300 | retrorsine | SLC22A1 protein promotes the reaction [CYP3A4 protein results in increased susceptibility to retrorsine] | 24799337 |
| C003300 | retrorsine | CYP3A4 protein results in increased metabolism of retrorsine | 24799337 |
| D017828 | Rifabutin | AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA] | 21856291 |
| D017828 | Rifabutin | Rifabutin results in increased expression of CYP3A4 mRNA | 16837568|2185629 |
| D012293 | Rifampin | AADAC mRNA affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 21856291 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | arsenic trioxide inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 16184197 |
| D012293 | Rifampin | Calcitriol promotes the reaction [Rifampin results in increased activity of CYP3A4 protein] | 21742782 |
| D012293 | Rifampin | Calcitriol promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 21742782 |
| D012293 | Rifampin | CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342 |
| D012293 | Rifampin | CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| D012293 | Rifampin | CYP3A4 protein inhibits the reaction [Rifampin results in decreased hydroxylation of Midazolam] | 12695342 |
| D012293 | Rifampin | CYP3A4 protein results in decreased susceptibility to Rifampin | 12695342 |
| D012293 | Rifampin | Dexamethasone promotes the reaction [Rifampin results in increased activity of CYP3A4 protein] | 18332045 |
| D012293 | Rifampin | Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 17003103 |
| D012293 | Rifampin | Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 17998298 |
| D012293 | Rifampin | Galactosamine inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 17936189 |
| D012293 | Rifampin | GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 23732298 |
| D012293 | Rifampin | [HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA | 25069801 |
| D012293 | Rifampin | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] | 23707768 |
| D012293 | Rifampin | Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]] | 23707768 |
| D012293 | Rifampin | Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | 21402137 |
| D012293 | Rifampin | Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] | 16146350 |
| D012293 | Rifampin | Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 16608920|1681950 |
| D012293 | Rifampin | Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 16819505 |
| D012293 | Rifampin | Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 21920351 |
| D012293 | Rifampin | Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 21920351 |
| D012293 | Rifampin | [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA | 24999631 |
| D012293 | Rifampin | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D012293 | Rifampin | NR1H3 mutant form inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 23732298 |
| D012293 | Rifampin | NR1I2 gene promotes the reaction [Rifampin results in increased expression of CYP3A4 protein] | 18799805 |
| D012293 | Rifampin | NR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 25313206|2828982 |
| D012293 | Rifampin | NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 12695340|2174278 |
| D012293 | Rifampin | NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 protein] | 27180241 |
| D012293 | Rifampin | [NR1I2 protein binds to NCOR2 protein] inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 12072427 |
| D012293 | Rifampin | [NR1I2 protein co-treated with Rifampin] results in decreased expression of CYP3A4 mRNA | 21764778 |
| D012293 | Rifampin | NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] | 25616597 |
| D012293 | Rifampin | NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 17003103|2112705 |
| D012293 | Rifampin | NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein] | 23707768 |
| D012293 | Rifampin | NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] | 25069801 |
| D012293 | Rifampin | NR3C1 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 10219967 |
| D012293 | Rifampin | ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 26341324 |
| D012293 | Rifampin | ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 26341324 |
| D012293 | Rifampin | oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]] | 17998298 |
| D012293 | Rifampin | [PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA | 25069801 |
| D012293 | Rifampin | Rifampin affects the activity of CYP3A4 protein | 15964336 |
| D012293 | Rifampin | Rifampin binds to and results in increased activity of CYP3A4 protein | 23899473 |
| D012293 | Rifampin | [Rifampin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 23845848 |
| D012293 | Rifampin | [Rifampin binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | 12851153|1285115 |
| D012293 | Rifampin | [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein | 22733800 |
| D012293 | Rifampin | [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA | 22733800 |
| D012293 | Rifampin | [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein | 22733800 |
| D012293 | Rifampin | [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 20361990|2209369 |
| D012293 | Rifampin | Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342 |
| D012293 | Rifampin | Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| D012293 | Rifampin | Rifampin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 12695342 |
| D012293 | Rifampin | Rifampin promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 21742782 |
| D012293 | Rifampin | Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 20233841 |
| D012293 | Rifampin | Rifampin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 20233841 |
| D012293 | Rifampin | Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine] | 9298257 |
| D012293 | Rifampin | Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA] | 21292004 |
| D012293 | Rifampin | Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP3A4 mRNA] | 21292004 |
| D012293 | Rifampin | Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 11581012 |
| D012293 | Rifampin | Rifampin promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] | 21641981 |
| D012293 | Rifampin | Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 12417264|2129200 |
| D012293 | Rifampin | Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] | 17998298 |
| D012293 | Rifampin | Rifampin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| D012293 | Rifampin | Rifampin results in increased activity of CYP3A4 protein | 12065438|1463632 |
| D012293 | Rifampin | [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008|2112705 |
| D012293 | Rifampin | Rifampin results in increased expression of and results in increased activity of CYP3A4 protein | 14709624|1576988 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP3A4 | 15554232|2315356 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP3A4 mRNA | 10219967|1085915 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP3A4 mRNA alternative form | 21998292 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP3A4 protein | 10640517|1258415 |
| D012293 | Rifampin | [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| D012293 | Rifampin | [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam | 22524704 |
| D012293 | Rifampin | [Rifampin results in increased expression of CYP3A4 protein] which results in increased hydroxylation of Testosterone | 22524704 |
| D012293 | Rifampin | [Rifampin results in increased expression of NR1I2 protein] which results in increased expression of and results in increased activity of CYP3A4 protein | 22687401 |
| D012293 | Rifampin | [RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA | 25069801 |
| D012293 | Rifampin | Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 28571685 |
| D012293 | Rifampin | Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 28571685 |
| D012293 | Rifampin | sodium arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A4 protein] | 15833926 |
| D012293 | Rifampin | sodium arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 15833926|2231032 |
| D012293 | Rifampin | [SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA | 25069801 |
| D012293 | Rifampin | sulforafan inhibits the reaction [Rifampin results in increased expression of CYP3A4] | 23153560 |
| D012293 | Rifampin | [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP3A4 mRNA | 29162470 |
| D012293 | Rifampin | Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 28571685 |
| D012293 | Rifampin | Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 28571685 |
| D012293 | Rifampin | Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 25616597 |
| D012293 | Rifampin | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | 21224054 |
| D012293 | Rifampin | NR1I2 affects the reaction [Rifampin results in increased activity of CYP3A4 protein] | 20361990 |
| D012293 | Rifampin | Rifampin results in increased activity of CYP3A4 protein | 20361990 |
| D012293 | Rifampin | "[CYP3A4 co-treated with Rifampin] affects the activity of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline" | 8844805 |
| D012293 | Rifampin | [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 18332045 |
| D012293 | Rifampin | Rifampin results in increased activity of CYP3A4 | 10669182 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP3A4 | 10653222|1907766 |
| D012293 | Rifampin | Rifampin results in increased expression of CYP3A4 mRNA | 25542188 |
| C018421 | rifapentine | AADAC mRNA affects the reaction [rifapentine results in increased expression of CYP3A4 mRNA] | 21856291 |
| C018421 | rifapentine | rifapentine results in increased expression of CYP3A4 mRNA | 16837568|2185629 |
| C042734 | rifaximin | rifaximin results in increased expression of CYP3A4 mRNA | 21141967|2750641 |
| D018967 | Risperidone | CYP3A4 gene polymorphism affects the susceptibility to Risperidone | 19395426 |
| D018967 | Risperidone | CYP3A4 protein affects the susceptibility to Risperidone | 19395426 |
| D018967 | Risperidone | "N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]" | 21402137 |
| D018967 | Risperidone | Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21402137 |
| D019438 | Ritonavir | CYP3A4 protein affects the metabolism of Ritonavir | 15286053 |
| D019438 | Ritonavir | CYP3A4 protein binds to Ritonavir analog | 27966929 |
| D019438 | Ritonavir | Ritonavir results in decreased activity of CYP3A4 protein | 15523003|1586065 |
| D019438 | Ritonavir | Ritonavir results in increased expression of CYP3A4 mRNA | 16837568 |
| D019438 | Ritonavir | CYP3A4 protein affects the metabolism of Ritonavir | 11197575 |
| D019438 | Ritonavir | Ritonavir results in decreased activity of CYP3A4 protein | 17581594|2111246 |
| D019438 | Ritonavir | Ritonavir results in decreased expression of CYP3A4 protein | 23548184 |
| C057006 | Ro 21-5104 | NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA] | 25313206 |
| C057006 | Ro 21-5104 | Ro 21-5104 results in increased expression of CYP3A4 mRNA | 25313206 |
| C057006 | Ro 21-5104 | Ro 21-5104 results in increased expression of CYP3A4 protein | 25313206 |
| C087123 | romidepsin | CYP3A4 protein affects the metabolism of romidepsin | 15635176 |
| C045282 | roquinimex | CYP3A4 protein results in increased metabolism of roquinimex | 11055268 |
| D012395 | Rose Bengal | Rose Bengal results in decreased activity of CYP3A4 protein | 20041016 |
| C089730 | rosiglitazone | rosiglitazone results in decreased activity of CYP3A4 protein | 12642470|1586065 |
| C089730 | rosiglitazone | rosiglitazone results in increased expression of and results in increased activity of CYP3A4 protein | 12642470 |
| C089730 | rosiglitazone | rosiglitazone results in increased expression of CYP3A4 mRNA | 12642470|1683756 |
| D015575 | Roxithromycin | Roxithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D015575 | Roxithromycin | Roxithromycin results in decreased activity of CYP3A4 protein | 16416302|1716469 |
| D015575 | Roxithromycin | Roxithromycin results in decreased expression of CYP3A4 mRNA | 16837568 |
| D015575 | Roxithromycin | Roxithromycin results in decreased activity of CYP3A4 protein | 16595573 |
| C100720 | RPR 121056 | CYP3A4 protein results in increased chemical synthesis of RPR 121056 | 15100172 |
| D012451 | Safrole | Safrole results in decreased activity of CYP3A4 protein | 15778010 |
| C010327 | salinomycin | CYP3A4 protein results in increased metabolism of salinomycin | 26282489 |
| C010327 | salinomycin | salinomycin results in decreased activity of CYP3A4 protein | 26282489 |
| D012500 | Santonin | [Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D019258 | Saquinavir | CYP3A4 protein results in increased metabolism of Saquinavir | 11824416 |
| D019258 | Saquinavir | Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein] | 15523003 |
| D019258 | Saquinavir | Saquinavir results in decreased activity of CYP3A4 protein | 15523003 |
| C515233 | saracatinib | CYP3A4 protein results in increased oxidation of saracatinib | 27769111 |
| C081294 | satraplatin | satraplatin results in decreased activity of CYP3A4 protein | 24882083 |
| C034557 | schizandrer A | [schizandrer A results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 21524698 |
| C034734 | schizandrin A | schizandrin A results in increased expression of CYP3A4 mRNA | 16267138 |
| C015499 | schizandrin B | schizandrin B results in increased expression of CYP3A4 mRNA | 16267138 |
| C033585 | schizandrol B | schizandrol B results in increased expression of CYP3A4 mRNA | 16267138 |
| D012631 | Secobarbital | Secobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D012631 | Secobarbital | Secobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D012643 | Selenium | Selenium results in decreased expression of CYP3A4 mRNA | 19244175 |
| C009237 | senecionine | senecionine results in increased expression of CYP3A4 mRNA | 26100227 |
| C009238 | senkirkine | senkirkine results in increased expression of CYP3A4 mRNA | 26100227 |
| D020280 | Sertraline | CYP3A4 protein results in decreased amination of and results in increased metabolism of Sertraline | 15547048 |
| D020280 | Sertraline | CYP3A4 protein results in decreased methylation of and results in increased metabolism of Sertraline | 15547048 |
| D020280 | Sertraline | Sertraline promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D020280 | Sertraline | CYP3A4 protein results in increased metabolism of Sertraline | 10653222 |
| C009250 | sevoflurane | CYP3A4 protein results in increased metabolism of sevoflurane | 7879937 |
| C526712 | shexiang baoxin | shexiang baoxin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 22178124 |
| C526712 | shexiang baoxin | shexiang baoxin results in increased expression of and results in increased activity of CYP3A4 protein | 22178124 |
| C526712 | shexiang baoxin | shexiang baoxin results in increased expression of CYP3A4 mRNA | 22178124 |
| C016101 | shikonin | shikonin results in decreased activity of CYP3A4 protein | 28941798 |
| C058254 | sibutramine | CYP3A4 protein affects the metabolism of sibutramine | 27838152 |
| C058254 | sibutramine | CYP3A4 protein affects the susceptibility to sibutramine | 27838152 |
| C058254 | sibutramine | CYP3A4 protein results in increased metabolism of sibutramine | 10492502 |
| D012822 | Silicon Dioxide | Silicon Dioxide results in decreased expression of CYP3A4 mRNA | 25351596 |
| C440975 | silybin | silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 15155549 |
| C440975 | silybin | silybin results in decreased activity of CYP3A4 protein | 15155549 |
| D019821 | Simvastatin | ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Simvastatin] | 19802823 |
| D019821 | Simvastatin | CYP3A4 polymorphism affects the susceptibility to Simvastatin | 15650881|1980282 |
| D019821 | Simvastatin | CYP3A4 protein affects the metabolism of Simvastatin | 16011971 |
| D019821 | Simvastatin | CYP3A4 protein results in increased metabolism of Simvastatin | 24927617 |
| D019821 | Simvastatin | [Simvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 24204015 |
| D019821 | Simvastatin | [Simvastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| D019821 | Simvastatin | Simvastatin results in increased expression of CYP3A4 mRNA | 12505310 |
| D019821 | Simvastatin | telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin] | 24927617 |
| D019821 | Simvastatin | CYP3A4 protein results in increased metabolism of Simvastatin | 11281188|1224360 |
| D019821 | Simvastatin | CYP3A4 results in increased metabolism of Simvastatin | 16159992|1980282 |
| D020123 | Sirolimus | CYP3A4 protein affects the metabolism of Sirolimus | 15707415|1596440 |
| D020123 | Sirolimus | CYP3A4 protein polymorphism affects the metabolism of Sirolimus | 15707415 |
| C106276 | sitaxsentan | sitaxsentan results in decreased activity of CYP3A4 protein | 23721565 |
| C570013 | SJ 000311413 | SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of CYP3A4 mRNA] | 21815645 |
| C017947 | sodium arsenite | sodium arsenite inhibits the reaction [Phenobarbital results in increased expression of and results in increased activity of CYP3A4 protein] | 15833926 |
| C017947 | sodium arsenite | sodium arsenite inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | 15833926 |
| C017947 | sodium arsenite | sodium arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A4 protein] | 15833926 |
| C017947 | sodium arsenite | sodium arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 15833926|2231032 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of and results in decreased activity of CYP3A4 protein | 15833926 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of CYP3A4 mRNA | 15833926 |
| C017947 | sodium arsenite | sodium arsenite results in increased activity of CYP3A4 protein | 19084030 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of CYP3A4 mRNA | 19084030 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of CYP3A4 protein | 19084030 |
| D020358 | Sodium Cholate | "[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein" | 1627548 |
| C471405 | sorafenib | CYP3A4 protein results in increased metabolism of sorafenib | 25489883 |
| C527814 | SPD-304 | CYP3A4 protein results in increased metabolism of SPD-304 | 18095656 |
| C527814 | SPD-304 | SPD-304 metabolite results in decreased activity of CYP3A4 protein | 18095656 |
| D013148 | Spironolactone | Spironolactone results in increased expression of CYP3A4 mRNA | 12505310 |
| C100355 | SR 12813 | allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]] | 25069801 |
| C100355 | SR 12813 | allyl isothiocyanate inhibits the reaction [SR 12813 results in increased expression of CYP3A4 mRNA] | 25069801 |
| C100355 | SR 12813 | bis(4-hydroxyphenyl)sulfone affects the reaction [SR 12813 results in increased expression of CYP3A4 protein] | 28916285 |
| C100355 | SR 12813 | NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA] | 25069801 |
| C100355 | SR 12813 | [SR 12813 binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 23845848 |
| C100355 | SR 12813 | SR 12813 promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] | 17998298 |
| C100355 | SR 12813 | [SR 12813 results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 19746521|2112705 |
| C100355 | SR 12813 | SR 12813 results in increased expression of CYP3A4 mRNA | 16565514|1974652 |
| C100355 | SR 12813 | SR 12813 results in increased expression of CYP3A4 protein | 28916285 |
| D019311 | Staurosporine | Staurosporine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | 17965521 |
| C031183 | stearic acid | INS protein inhibits the reaction [stearic acid results in decreased expression of CYP3A4 mRNA] | 26739624 |
| C031183 | stearic acid | stearic acid results in decreased expression of CYP3A4 mRNA | 26739624 |
| C031183 | stearic acid | stearic acid results in decreased expression of CYP3A4 protein | 26739624 |
| D013241 | Sterigmatocystin | CYP3A4 protein affects the metabolism of Sterigmatocystin | 2271712|2655891 |
| D013241 | Sterigmatocystin | [CYP3A4 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin] which results in increased chemical synthesis of Sterigmatocystin metabolite | 20929267 |
| D013241 | Sterigmatocystin | CYP3A4 protein results in increased glutathionylation of Sterigmatocystin | 20929267 |
| D013256 | Steroids | Steroids results in increased expression of CYP3A4 | 15955870 |
| C012042 | steviol | steviol binds to and results in decreased activity of CYP3A4 protein | 28887089 |
| C012042 | steviol | steviol results in increased expression of CYP3A4 mRNA | 28887089 |
| C012042 | steviol | steviol results in increased expression of CYP3A4 protein | 28887089 |
| C012043 | stevioside | stevioside binds to and results in decreased activity of CYP3A4 protein | 28887089 |
| C012043 | stevioside | stevioside results in increased expression of CYP3A4 mRNA | 28887089 |
| C012043 | stevioside | stevioside results in increased expression of CYP3A4 protein | 28887089 |
| C021092 | stiripentol | stiripentol results in decreased activity of CYP3A4 protein | 16022579 |
| C024075 | styrofoam | styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein] | 19909766 |
| C024075 | styrofoam | styrofoam analog results in decreased activity of CYP3A4 protein | 19909766 |
| D013418 | Sulfamethazine | Sulfamethazine results in increased activity of CYP3A4 protein | 12065438 |
| D013420 | Sulfamethoxazole | [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole | 19501153 |
| D013442 | Sulfinpyrazone | Sulfinpyrazone results in increased activity of CYP3A4 protein | 12065438|9512926 |
| D013442 | Sulfinpyrazone | Sulfinpyrazone results in increased expression of CYP3A4 mRNA | 10219967|1683756 |
| D013444 | Sulfisoxazole | Sulfisoxazole results in increased expression of and results in increased activity of CYP3A4 protein | 18505790 |
| D013444 | Sulfisoxazole | Sulfisoxazole results in increased expression of CYP3A4 mRNA | 18505790 |
| C016766 | sulforafan | sulforafan inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] | 26775663 |
| C016766 | sulforafan | sulforafan inhibits the reaction [Rifampin results in increased expression of CYP3A4] | 23153560 |
| C016766 | sulforafan | sulforafan results in decreased expression of CYP3A4 mRNA | 20442190|2677566 |
| D014284 | Triiodothyronine | SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of CYP3A4 mRNA] | 21815645 |
| D014284 | Triiodothyronine | Triiodothyronine results in increased expression of CYP3A4 mRNA | 21815645 |
| D013619 | Tacrine | CYP3A4 protein results in increased susceptibility to Tacrine | 21540358 |
| D016559 | Tacrolimus | CYP3A4 protein affects the metabolism of Tacrolimus | 15010519|1591944 |
| D016559 | Tacrolimus | CYP3A4 protein results in decreased methylation of Tacrolimus | 15951320 |
| D016559 | Tacrolimus | CYP3A4 protein results in increased metabolism of Tacrolimus | 15855244 |
| D016559 | Tacrolimus | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Tacrolimus] | 15855244 |
| C508967 | tamarixetin | tamarixetin results in increased expression of CYP3A4 mRNA | 26238175 |
| D013629 | Tamoxifen | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen | 23397584 |
| D013629 | Tamoxifen | CYP3A4 protein results in increased metabolism of Tamoxifen | 20507880|2928560 |
| D013629 | Tamoxifen | "[CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene" | 29285606 |
| D013629 | Tamoxifen | [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene | 20507880 |
| D013629 | Tamoxifen | CYP3A4 protein results in increased susceptibility to Tamoxifen | 26718876 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D013629 | Tamoxifen | Tamoxifen metabolite results in increased activity of CYP3A4 protein | 29285606 |
| D013629 | Tamoxifen | Tamoxifen metabolite results in increased expression of CYP3A4 mRNA | 29285606 |
| D013629 | Tamoxifen | Tamoxifen results in decreased activity of CYP3A4 protein | 12419016 |
| D013629 | Tamoxifen | Tamoxifen results in increased activity of CYP3A4 protein | 29285606 |
| D013629 | Tamoxifen | Tamoxifen results in increased expression of CYP3A4 mRNA | 18839173 |
| D013629 | Tamoxifen | [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Tamoxifen | 14652237 |
| D013629 | Tamoxifen | Tamoxifen results in decreased activity of CYP3A4 protein | 18420780 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| C021751 | tanshinone | NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein] | 18805405 |
| C021751 | tanshinone | NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] | 18805405 |
| C021751 | tanshinone | NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] | 18805405 |
| C021751 | tanshinone | tanshinone results in increased expression of CYP3A4 protein | 18805405 |
| C087114 | tebuconazole | [tebuconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 29420809 |
| C082026 | tebufenozide | tebufenozide results in increased expression of CYP3A4 mRNA | 22310298 |
| C486464 | telaprevir | telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin] | 24927617 |
| C106791 | telithromycin | telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone] | 19755414 |
| C106791 | telithromycin | telithromycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of noroxycodone] | 19755414 |
| C106791 | telithromycin | telithromycin results in decreased activity of CYP3A4 protein | 16556082|1975541 |
| D013693 | Temazepam | Temazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D013693 | Temazepam | Temazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D013713 | Teniposide | Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| D013713 | Teniposide | CYP3A4 protein results in decreased methylation of Teniposide | 8114683 |
| D013713 | Teniposide | Dexamethasone inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| D013713 | Teniposide | Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| D013713 | Teniposide | Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] | 8114683 |
| C041359 | terbinafine | CYP3A4 protein results in increased susceptibility to terbinafine | 21540358 |
| D016593 | Terfenadine | CYP3A4 protein affects the metabolism of Terfenadine | 15383492 |
| D016593 | Terfenadine | CYP3A4 protein results in increased degradation of Terfenadine | 15684493 |
| D016593 | Terfenadine | CYP3A4 protein results in increased metabolism of Terfenadine | 15869686 |
| D016593 | Terfenadine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine] | 15869686 |
| D016593 | Terfenadine | Terfenadine analog results in increased expression of CYP3A4 mRNA | 12505310 |
| D016593 | Terfenadine | Terfenadine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D016593 | Terfenadine | Terfenadine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D016593 | Terfenadine | CYP3A4 protein results in increased metabolism of Terfenadine | 12052668|9550749 |
| D016593 | Terfenadine | [Plant Extracts results in decreased activity of CYP3A4 protein] which results in increased abundance of Terfenadine | 9550749 |
| D013739 | Testosterone | alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | 19299527 |
| D013739 | Testosterone | Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 22652334 |
| D013739 | Testosterone | Azithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D013739 | Testosterone | Carbofuran promotes the reaction [CYP3A4 protein affects the metabolism of Testosterone] | 15560889 |
| D013739 | Testosterone | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D013739 | Testosterone | CYP3A4 protein affects the hydroxylation of Testosterone | 2271712 |
| D013739 | Testosterone | CYP3A4 protein affects the metabolism of Testosterone | 12818727|1554871 |
| D013739 | Testosterone | CYP3A4 protein results in increased hydrolysis of Testosterone | 11377097|1929952 |
| D013739 | Testosterone | CYP3A4 protein results in increased hydroxylation of Testosterone | 12433797|1515554 |
| D013739 | Testosterone | [CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | 16595712|2823872 |
| D013739 | Testosterone | [CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones | 28238727 |
| D013739 | Testosterone | CYP3A4 protein results in increased metabolism of Testosterone | 12401345|1256944 |
| D013739 | Testosterone | [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | 17084830|1913503 |
| D013739 | Testosterone | CYP3A4 protein results in increased oxidation of Testosterone | 21964418 |
| D013739 | Testosterone | deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 23876819 |
| D013739 | Testosterone | Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 22652334 |
| D013739 | Testosterone | Erythromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D013739 | Testosterone | fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 17084830 |
| D013739 | Testosterone | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | 11377097 |
| D013739 | Testosterone | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 20233841|2086332 |
| D013739 | Testosterone | Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 28238727 |
| D013739 | Testosterone | Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones] | 28238727 |
| D013739 | Testosterone | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | 12569440|2385098 |
| D013739 | Testosterone | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone | 25343516 |
| D013739 | Testosterone | [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Testosterone | 26239802 |
| D013739 | Testosterone | Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 22652334 |
| D013739 | Testosterone | obeticholic acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | 27939613 |
| D013739 | Testosterone | Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 19695866 |
| D013739 | Testosterone | perfluorooctane sulfonic acid inhibits the reaction [CYP3A4 protein results in increased oxidation of Testosterone] | 21964418 |
| D013739 | Testosterone | potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]] | 22652334 |
| D013739 | Testosterone | potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]] | 22652334 |
| D013739 | Testosterone | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | 12569440 |
| D013739 | Testosterone | [Rifampin results in increased expression of CYP3A4 protein] which results in increased hydroxylation of Testosterone | 22524704 |
| D013739 | Testosterone | Roxithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302 |
| D013739 | Testosterone | silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 15155549 |
| D013739 | Testosterone | Testosterone inhibits the reaction [Ethinyl Estradiol results in decreased activity of CYP3A4 protein] | 11907170 |
| D013739 | Testosterone | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302|2086332 |
| D013739 | Testosterone | Testosterone results in decreased activity of CYP3A4 protein | 18420780 |
| D013739 | Testosterone | alpha-naphthoflavone promotes the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | 19299527 |
| D013739 | Testosterone | CYP3A4 protein results in increased hydrolysis of Testosterone | 19299527 |
| D013739 | Testosterone | [CYP3A4 protein mutant form co-treated with cumene hydroperoxide] results in increased metabolism of Testosterone | 16987939 |
| D013739 | Testosterone | CYP3A4 protein mutant form results in increased metabolism of Testosterone | 16987939 |
| D013739 | Testosterone | CYP3A4 protein results in increased hydroxylation of Testosterone | 21964476 |
| D013739 | Testosterone | CYP3A4 protein results in increased metabolism of Testosterone | 11231118 |
| D013739 | Testosterone | Dexamethasone promotes the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 21964476 |
| D013739 | Testosterone | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 21964476 |
| D013739 | Testosterone | Testosterone affects the reaction [CYP3A4 protein affects the chemical synthesis of 1-hydroxypyrene] | 15910734 |
| D013739 | Testosterone | Testosterone affects the reaction [CYP3A4 protein affects the metabolism of pyrene] | 15910734 |
| C020806 | tetrabromobisphenol A | CYP3A4 protein results in increased metabolism of tetrabromobisphenol A | 22417763 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of CYP3A4 mRNA | 22298810 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP3A4 mRNA | 29162470 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 28571685 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | 28571685 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of CYP3A4 mRNA | 16985168|2857168 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of CYP3A4 mRNA | 23669205 |
| D013752 | Tetracycline | Tetracycline results in increased expression of and results in increased activity of CYP3A4 protein | 18505790 |
| D013752 | Tetracycline | Tetracycline results in increased expression of CYP3A4 mRNA | 18505790 |
| D013752 | Tetracycline | Tetracycline results in decreased expression of CYP3A4 mRNA | 19224547 |
| C009424 | tetramethrin | CYP3A4 protein results in increased metabolism of tetramethrin | 19249324 |
| C009438 | tetrandrine | CYP3A4 protein results in increased glutathionylation of tetrandrine | 21992520 |
| D013792 | Thalidomide | CYP3A4 protein results in increased hydroxylation of Thalidomide | 20443640 |
| D013792 | Thalidomide | [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide | 20443640 |
| D013792 | Thalidomide | CYP3A4 protein results in increased metabolism of Thalidomide | 28745489 |
| D013792 | Thalidomide | Thalidomide results in increased expression of CYP3A4 mRNA | 24460184|2849604 |
| D013792 | Thalidomide | Thalidomide results in increased expression of CYP3A4 protein | 24460184 |
| D013792 | Thalidomide | CYP3A4 protein results in increased hydroxylation of Thalidomide | 20443640 |
| D013792 | Thalidomide | [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide | 20443640 |
| D019284 | Thapsigargin | NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] | 25616597 |
| D019284 | Thapsigargin | Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | 25616597 |
| D013806 | Theophylline | [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] | 11408986 |
| D013827 | Thiabendazole | Thiabendazole results in increased expression of CYP3A4 mRNA | 18570159 |
| C416660 | thiamethoxam | [NADP co-treated with CYP3A4 protein] results in increased activity of thiamethoxam | 16153789 |
| D013859 | Thiocarbamates | NR1I2 protein promotes the reaction [Thiocarbamates results in increased expression of CYP3A4 mRNA] | 17293382 |
| D013859 | Thiocarbamates | Thiocarbamates results in increased expression of CYP3A4 mRNA | 17293382 |
| C109005 | thiocoraline | CYP3A4 protein affects the metabolism of thiocoraline | 15122071 |
| D008063 | Thioctic Acid | Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D013881 | Thioridazine | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine | 23397584 |
| D013881 | Thioridazine | Thioridazine results in decreased activity of CYP3A4 protein | 15135088 |
| D013852 | Thiotepa | CYP3A4 gene SNP affects the export of Thiotepa | 19076156 |
| D013852 | Thiotepa | CYP3A4 protein affects the susceptibility to Thiotepa | 19076156 |
| D013974 | Thyroxine | [Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D013988 | Ticlopidine | CYP3A4 protein results in increased degradation of Ticlopidine | 22651985 |
| D013988 | Ticlopidine | CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite | 19170597 |
| D013988 | Ticlopidine | CYP3A4 protein results in increased susceptibility to Ticlopidine | 22651985 |
| D013988 | Ticlopidine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine] | 22651985 |
| D013988 | Ticlopidine | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine] | 22651985 |
| D013988 | Ticlopidine | Ticlopidine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D014011 | Tinidazole | CYP3A4 protein affects the metabolism of Tinidazole | 12920490 |
| C423915 | TO-901317 | NR1H3 protein inhibits the reaction [[TO-901317 co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA] | 23732298 |
| C423915 | TO-901317 | RXRA protein promotes the reaction [[TO-901317 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA] | 23732298 |
| C423915 | TO-901317 | RXRA protein promotes the reaction [[TO-901317 co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA] | 23732298 |
| C423915 | TO-901317 | [TO-901317 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA | 23732298 |
| C423915 | TO-901317 | [TO-901317 co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | 23732298 |
| C423915 | TO-901317 | TO-901317 results in increased expression of CYP3A4 mRNA | 23732298 |
| C082032 | tocotrienol, alpha | "tocotrienol, alpha results in increased expression of CYP3A4" | 15269186 |
| C082089 | tocotrienol, beta | "tocotrienol, beta results in increased expression of CYP3A4" | 15269186 |
| C082097 | tocotrienol, delta | "tocotrienol, delta results in increased expression of CYP3A4" | 15269186 |
| C479163 | tofacitinib | CYP3A4 protein results in increased oxidation of tofacitinib metabolite | 27117606 |
| C066340 | tolcapone | CYP3A4 protein results in increased susceptibility to tolcapone | 21540358 |
| C052342 | topiramate | topiramate results in increased activity of CYP3A4 protein | 14636322 |
| C052342 | topiramate | topiramate results in increased expression of CYP3A4 mRNA | 14636322 |
| C052342 | topiramate | topiramate results in increased expression of CYP3A4 protein | 14636322 |
| D014147 | Tramadol | CYP3A4 protein results in increased metabolism of Tramadol | 20305307 |
| C507866 | trans-1,2-dihydro-1,2-naphthalenediol | "CYP3A4 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediol" | 16243959 |
| D014191 | Tranylcypromine | Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] | 24120545 |
| D014196 | Trazodone | Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | 12584149 |
| D014196 | Trazodone | [SOD2 co-treated with CYP3A4] affects the susceptibility to Trazodone | 19501153 |
| D014196 | Trazodone | CYP3A4 protein affects the metabolism of Trazodone | 18238857 |
| D014212 | Tretinoin | CYP3A4 protein results in increased hydroxylation of Tretinoin | 10874126 |
| D014212 | Tretinoin | Tretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | 16632523 |
| D014212 | Tretinoin | Tretinoin results in decreased activity of CYP3A4 protein | 18420780 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of CYP3A4 mRNA | 16985168 |
| D014212 | Tretinoin | Tretinoin results in increased activity of CYP3A4 protein | 16632523 |
| D014212 | Tretinoin | [Tretinoin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| C032910 | triadimefon | "[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA" | 25028461 |
| D014229 | Triazolam | CYP3A4 protein affects the metabolism of Triazolam | 15286053|1604267 |
| D014229 | Triazolam | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam] | 10952769 |
| D014229 | Triazolam | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam | 22447115 |
| D014229 | Triazolam | Nicardipine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Triazolam] | 15863898 |
| D014229 | Triazolam | Triazolam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D014229 | Triazolam | Triazolam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D014229 | Triazolam | CYP3A4 protein results in increased metabolism of Triazolam | 10997940 |
| D014229 | Triazolam | Magnesium Chloride affects the reaction [CYP3A4 protein results in increased metabolism of Triazolam] | 10997940 |
| C039783 | tributyl citrate | tributyl citrate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | 21742782 |
| D014260 | Triclosan | Triclosan results in increased activity of CYP3A4 protein | 23899473 |
| D013721 | Triethylenephosphoramide | CYP3A4 gene SNP affects the export of Triethylenephosphoramide | 19076156 |
| D013721 | Triethylenephosphoramide | CYP3A4 protein affects the susceptibility to Triethylenephosphoramide | 19076156 |
| D014271 | Trifluridine | [Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| C001899 | triptolide | CYP3A4 protein results in increased hydroxylation of triptolide | 19879934 |
| C012085 | tris(2,3-dibromopropyl)phosphate | "CYP3A4 protein affects the metabolism of tris(2,3-dibromopropyl)phosphate" | 2271712|2655891 |
| C057693 | troglitazone | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone | 23397584 |
| C057693 | troglitazone | CYP3A4 protein results in increased metabolism of troglitazone | 19356091 |
| C057693 | troglitazone | CYP3A4 protein results in increased susceptibility to troglitazone | 26706816|2876204 |
| C057693 | troglitazone | troglitazone results in decreased activity of CYP3A4 protein | 12642470|1586065 |
| C057693 | troglitazone | troglitazone results in increased activity of CYP3A4 protein | 10752642 |
| C057693 | troglitazone | [troglitazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 17041008 |
| C057693 | troglitazone | troglitazone results in increased expression of and results in increased activity of CYP3A4 protein | 12642470 |
| C057693 | troglitazone | troglitazone results in increased expression of CYP3A4 mRNA | 10752642|1250531 |
| C057693 | troglitazone | troglitazone results in increased expression of CYP3A4 protein | 10752642|2252470 |
| C057693 | troglitazone | [troglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol | 22524704 |
| C057693 | troglitazone | [SOD2 co-treated with CYP3A4] affects the susceptibility to troglitazone | 19501153 |
| C057693 | troglitazone | CYP3A4 protein results in increased metabolism of troglitazone | 11281188 |
| C057693 | troglitazone | [GCSH mRNA co-treated with CYP3A4 protein] affects the susceptibility to troglitazone | 19958826 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam] | 9600717 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] | 12695342 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] | 12695342 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone] | 20863320 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | 16207822 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | 12695342 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | 16416302|2086332 |
| D014217 | Troleandomycin | "Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]" | 19697924 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Fluoxetine] | 11752104 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] | 15764719 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 16049126 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] | 1740010 |
| D014217 | Troleandomycin | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine] | 20863320 |
| D014217 | Troleandomycin | Troleandomycin promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D014217 | Troleandomycin | Troleandomycin results in decreased activity of CYP3A4 protein | 11409940|1175210 |
| D014217 | Troleandomycin | [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of N-desmethyltamoxifen | 14652237 |
| D014217 | Troleandomycin | [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Tamoxifen | 14652237 |
| D014217 | Troleandomycin | Troleandomycin results in increased activity of CYP3A4 protein | 9512926 |
| D014217 | Troleandomycin | Troleandomycin results in increased expression of and results in increased activity of CYP3A4 protein | 18505790 |
| D014217 | Troleandomycin | Troleandomycin results in increased expression of CYP3A4 mRNA | 18505790 |
| D014217 | Troleandomycin | Troleandomycin promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D014217 | Troleandomycin | Troleandomycin results in decreased activity of CYP3A4 | 10910959 |
| D014217 | Troleandomycin | Troleandomycin results in decreased activity of CYP3A4 protein | 10828259|1150612 |
| C113580 | U 0126 | Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A4 mRNA] | 24819614 |
| C113580 | U 0126 | Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein] | 24819614 |
| C113580 | U 0126 | U 0126 affects the activity of CYP3A4 protein | 24819614 |
| C113580 | U 0126 | U 0126 results in increased expression of CYP3A4 mRNA | 24819614 |
| C113580 | U 0126 | U 0126 results in increased expression of CYP3A4 protein | 24819614 |
| C112106 | UAB 30 | UAB 30 results in increased expression of CYP3A4 mRNA | 19135037 |
| D014580 | Ursodeoxycholic Acid | CYP3A4 protein affects the metabolism of Ursodeoxycholic Acid | 15708356 |
| D014580 | Ursodeoxycholic Acid | [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic Acid | 19487251 |
| D014580 | Ursodeoxycholic Acid | Ursodeoxycholic Acid results in increased expression of CYP3A4 mRNA | 16678547 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of CYP3A4 mRNA | 29154799 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of CYP3A4 mRNA | 25084468 |
| C043425 | vanoxerine | CYP3A4 protein results in decreased degradation of vanoxerine | 11502731 |
| C043425 | vanoxerine | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine | 11502731 |
| C043425 | vanoxerine | [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine | 11502731 |
| C521013 | veliparib | CYP3A4 protein results in increased metabolism of veliparib | 21436403 |
| D000069470 | Venlafaxine Hydrochloride | CYP3A4 protein results in increased metabolism of Venlafaxine Hydrochloride | 21840145 |
| D000069470 | Venlafaxine Hydrochloride | [CYP3A4 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of N-desmethylvenlafaxine | 21840145 |
| D000069470 | Venlafaxine Hydrochloride | "[[CYP3A4 protein results in increased metabolism of Venlafaxine Hydrochloride] which results in increased abundance of N-desmethylvenlafaxine] which results in increased abundance of N,O-didesmethylvenlafaxine" | 21840145 |
| D014700 | Verapamil | CYP3A4 protein affects the metabolism of Verapamil | 15286053|1569282 |
| D014700 | Verapamil | naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] | 16013069 |
| D014700 | Verapamil | Verapamil inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D014700 | Verapamil | Verapamil results in decreased activity of CYP3A4 protein | 15689501|1586065 |
| D014700 | Verapamil | [Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 25455453 |
| D014700 | Verapamil | Verapamil results in decreased activity of CYP3A4 protein | 18420780 |
| D014700 | Verapamil | CYP3A4 protein affects the metabolism of Verapamil | 16013069 |
| D014700 | Verapamil | naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] | 16013069 |
| D014700 | Verapamil | Verapamil inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | 19299527 |
| D014700 | Verapamil | CYP3A4 protein affects the metabolism of Verapamil | 15905061 |
| D014700 | Verapamil | Verapamil results in decreased activity of CYP3A4 protein | 11724091 |
| C515147 | vestitol | vestitol results in decreased activity of CYP3A4 protein | 16204965 |
| D014750 | Vincristine | CYP3A4 protein results in increased metabolism of Vincristine | 19346885 |
| D014807 | Vitamin D | Vitamin D analog results in increased expression of CYP3A4 mRNA | 17965521 |
| D002762 | Cholecalciferol | Cholecalciferol metabolite results in increased expression of CYP3A4 | 11991950 |
| D002762 | Cholecalciferol | Cholecalciferol results in decreased activity of CYP3A4 protein | 18420780 |
| D002762 | Cholecalciferol | Cholecalciferol results in increased expression of CYP3A4 mRNA | 16207822 |
| D002762 | Cholecalciferol | CYP3A4 protein results in increased hydroxylation of Cholecalciferol | 16207822 |
| D002762 | Cholecalciferol | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | 16207822 |
| D002762 | Cholecalciferol | Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | 16207822 |
| D002762 | Cholecalciferol | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | 16207822 |
| D014810 | Vitamin E | Vitamin E results in decreased expression of CYP3A4 mRNA | 19244175 |
| D065819 | Voriconazole | CYP3A4 protein affects the metabolism of Voriconazole | 15914520 |
| D065819 | Voriconazole | Voriconazole results in decreased activity of CYP3A4 protein | 15328084|1591452 |
| D065819 | Voriconazole | Voriconazole results in decreased activity of CYP3A4 protein | 12013365|1655608 |
| C574123 | walrycin A | NR1I2 protein affects the reaction [walrycin A results in increased expression of CYP3A4 mRNA] | 22314385 |
| C574123 | walrycin A | walrycin A results in increased expression of CYP3A4 mRNA | 22314385 |
| D014859 | Warfarin | CYP3A4 protein affects the hydroxylation of Warfarin | 2271712 |
| D014859 | Warfarin | CYP3A4 protein affects the metabolism of Warfarin | 15280511|1603536 |
| D014859 | Warfarin | CYP3A4 SNP affects the susceptibility to Warfarin | 28079798 |
| D014859 | Warfarin | [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | 20735727 |
| D014859 | Warfarin | Warfarin results in decreased activity of CYP3A4 protein | 18420780 |
| D014966 | Xanthenes | Xanthenes results in decreased activity of CYP3A4 protein | 18686201|2004101 |
| C530155 | YM 758 | CYP3A4 protein results in increased metabolism of YM 758 | 19230594 |
| C530155 | YM 758 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758] | 19230594 |
| C530155 | YM 758 | Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758] | 19230594 |
| C530155 | YM 758 | YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 19230594 |
| C530155 | YM 758 | YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Nifedipine] | 19230594 |
| C530155 | YM 758 | YM 758 results in increased expression of CYP3A4 mRNA | 19230594 |
| D015016 | Yohimbine | CYP3A4 gene polymorphism affects the metabolism of Yohimbine | 15289791 |
| C062735 | zafirlukast | CYP3A4 protein results in increased metabolism of zafirlukast | 16167835 |
| C062735 | zafirlukast | zafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | 15370959 |
| C062735 | zafirlukast | zafirlukast metabolite results in decreased activity of CYP3A4 protein | 16167835 |
| C062735 | zafirlukast | zafirlukast results in decreased activity of CYP3A4 protein | 15370959 |
| D015215 | Zidovudine | [SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine | 19501153 |
| C063449 | zileuton | zileuton results in decreased activity of CYP3A4 protein | 15482930 |
| C049109 | zolpidem | CYP3A4 protein results in increased metabolism of zolpidem | 16449812 |
| C053228 | zopiclone N-oxide | CYP3A4 protein results in increased abundance of zopiclone N-oxide | 27320963 |