Gene: FAM84B

157638
BCMP101|NSE2
family with sequence similarity 84 member B
protein-coding
8q24.21
Ensembl:ENSG00000168672 MIM:609483 Vega:OTTHUMG00000165034 UniprotKB:Q96KN1
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.689e-2 (AD)  8.042e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03959515chr8:127569677FAM84B3.900e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMP20.811
VEZF10.811
SGK10.806
MTUS10.801
TMEM1650.797
CREB50.795
ADIPOR20.795
DOCK50.793
C18orf540.792
USP540.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBLN7-0.424
CHRNA2-0.41
CUX2-0.396
PRTN3-0.395
CDH22-0.384
RTP1-0.378
BEAN1-0.376
FFAR4-0.375
FREM3-0.371
HCN4-0.368

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of FAM84B mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of FAM84B mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM84B mRNA"27188386
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of FAM84B mRNA17011747
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM84B mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FAM84B mRNA21641981
D001280AtrazineAtrazine results in increased expression of FAM84B mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAM84B mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FAM84B mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FAM84B mRNA"19150397|2038263
D004958EstradiolEstradiol results in decreased expression of FAM84B mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of FAM84B mRNA25594700
D002220CarbamazepineCarbamazepine affects the expression of FAM84B mRNA25979313
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of FAM84B mRNA25596134
C059262cidofovircidofovir results in increased expression of FAM84B mRNA25596134
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of FAM84B mRNA18078969
D003300Copper[Disulfiram binds to Copper] which results in increased expression of FAM84B mRNA24690739
D016572CyclosporineCyclosporine results in decreased expression of FAM84B mRNA25596134
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FAM84B mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FAM84B mRNA27392435
D002945CisplatinCisplatin results in increased expression of FAM84B mRNA25596134|2739243
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of FAM84B mRNA23625948
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FAM84B mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of FAM84B mRNA17011747
D002117CalcitriolCalcitriol results in increased expression of FAM84B mRNA26485663
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of FAM84B mRNA24690739
D000431EthanolEthanol results in increased expression of FAM84B mRNA28986285
D019833GenisteinGenistein results in decreased expression of FAM84B mRNA23019147
D005839GentamicinsGentamicins results in decreased expression of FAM84B mRNA22061828
D017313FenretinideFenretinide results in decreased expression of FAM84B mRNA28973697
D017313FenretinideFenretinide results in increased expression of FAM84B mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FAM84B mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TRIM33 mutant form results in increased expression of FAM84B mRNA]27432991
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of FAM84B mRNA20843944
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of FAM84B mRNA28349193
D015741MetriboloneMetribolone results in increased expression of FAM84B mRNA17010196
D009151Mustard GasMustard Gas results in increased expression of FAM84B mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAM84B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FAM84B mRNA"25620056
D010100OxygenOxygen deficiency results in decreased expression of FAM84B mRNA25596134
D010416PentachlorophenolPentachlorophenol results in increased expression of FAM84B mRNA24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of FAM84B mRNA23892564
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of FAM84B mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of FAM84B mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of FAM84B mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FAM84B mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of FAM84B mRNA24780913
D012834SilverSilver results in decreased expression of FAM84B mRNA27131904
D012906SmokeSmoke results in decreased expression of FAM84B mRNA21095227
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of FAM84B mRNA25172293
D013853ThioacetamideThioacetamide results in increased expression of FAM84B mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of FAM84B mRNA23557971
C024746tobacco tartobacco tar results in decreased expression of FAM84B mRNA19559774
D014212TretinoinTretinoin results in increased expression of FAM84B mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM84B mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FAM84B mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FAM84B mRNA19042947
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of FAM84B mRNA18078969
D014635Valproic AcidValproic Acid affects the expression of FAM84B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FAM84B mRNA24383497
D014635Valproic AcidValproic Acid results in increased expression of FAM84B mRNA23179753|2800136
C088658zoledronic acidzoledronic acid results in decreased expression of FAM84B mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12477722  25416956  25640309  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA12477722  25468996  
GO:0005886plasma membrane-IDA12477722  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23985253[Association of TET2, LMTK2 and FAM84B gene expression with prostate cancer risk in Chinese patients]. (2013 Apr)Wang NNZhonghua Zhong Liu Za Zhi