Gene: CYP4A11

1579
CP4Y|CYP4A2|CYP4AII
cytochrome P450 family 4 subfamily A member 11
protein-coding
1p33
Ensembl:ENSG00000187048 MIM:601310 Vega:OTTHUMG00000008020 UniprotKB:Q02928
NG_007932.1
PubMed
0   ANCO-SNPs
ND
4   
4.882e-1 (AD)  3.842e-1 (ND)   (Frontal_Cortex)
9.857e-1 (AD)  9.925e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TARBP10.68
BFSP10.661
NUDT180.66
ICA10.656
BEST40.645
PCYOX1L0.638
ARMCX40.632
TPBGL0.625
HGSNAT0.622
SLC25A450.618

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.493
ANGPT2-0.444
PXDC1-0.442
CLEC2B-0.442
FAM167B-0.442
ACTL6A-0.433
RAB13-0.43
P4HA1-0.428
CNN2-0.426
DLEU1-0.424

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00082PegvisomantBiotechDrug218620-50-9ApprovedEnzyme
DB00448LansoprazoleSmall Molecule103577-45-3Approved|InvestigationalEnzyme
DB00515CisplatinSmall Molecule15663-27-1ApprovedEnzyme
DB00636ClofibrateSmall Molecule637-07-0Approved|InvestigationalEnzyme
DB00655EstroneSmall Molecule53-16-7ApprovedEnzyme
DB00738PentamidineSmall Molecule100-33-4Approved|InvestigationalEnzyme
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
DB01045RifampicinSmall Molecule13292-46-1ApprovedEnzyme
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalEnzyme
DB01234DexamethasoneSmall Molecule50-02-2Approved|InvestigationalEnzyme
DB04977PlitidepsinSmall Molecule137219-37-5InvestigationalEnzyme
DB11077Polyethylene glycol 400Small Molecule25322-68-3ApprovedEnzyme
DB11156PyrantelSmall Molecule15686-83-6ApprovedEnzyme
DB14004TildrakizumabBiotechDrug1326244-10-3ApprovedEnzyme
ID Drug Name Action PubMed
C0065731,4-androstadiene-3,17-dione"[boldenone co-treated with 1,4-androstadiene-3,17-dione] results in increased expression of CYP4A11 mRNA"22713311
C0353421,4-naphthoquinone"CYP4A11 protein results in increased abundance of 1,4-naphthoquinone"16243959
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CYP4A11 mRNA"16712844
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"CYP4A11 protein results in increased secretion of 20-hydroxy-5,8,11,14-eicosatetraenoic acid"23747687
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"isoliquiritigenin inhibits the reaction [CYP4A11 protein results in increased secretion of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]"23747687
C0227762-bromopalmitate2-bromopalmitate results in increased expression of CYP4A11 mRNA16712844
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of CYP4A11 mRNA15982314
C5444715-hydroxythalidomideCYP4A11 protein results in increased metabolism of 5-hydroxythalidomide24350712
D000111AcetylcysteineAcetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A11 mRNA]19647067
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP4A11 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CYP4A11 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CYP4A11 mRNA21298039
D001280AtrazineAtrazine results in increased expression of CYP4A11 mRNA22378314
D001629BezafibrateAcetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A11 mRNA]19647067
D001629BezafibrateBezafibrate results in increased expression of CYP4A11 mRNA16712844|1964706
D001629BezafibrateTretinoin inhibits the reaction [Bezafibrate results in increased expression of CYP4A11 mRNA]16712844
C006780bisphenol Abisphenol A results in decreased expression of CYP4A11 mRNA25181051
C013915boldenone"[boldenone co-treated with 1,4-androstadiene-3,17-dione] results in increased expression of CYP4A11 mRNA"22713311
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP4A11 mRNA17851650
D002994ClofibrateClofibrate results in increased expression of CYP4A11 mRNA19952500
D002994ClofibrateClofibrate results in increased expression of CYP4A11 mRNA19647067|2655847
D002994ClofibrateClofibrate results in increased expression of CYP4A11 protein26558470
D003671DEETDEET results in decreased expression of CYP4A11 mRNA27091632
D003671DEET[fipronil co-treated with DEET] results in decreased expression of CYP4A11 mRNA27091632
D002945CisplatinCisplatin results in increased expression of CYP4A11 mRNA26558470
D002945CisplatinCisplatin results in increased expression of CYP4A11 protein26558470
D011345FenofibrateFenofibrate results in increased expression of CYP4A11 mRNA25572481
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of CYP4A11 mRNA27091632
C082360fipronilfipronil results in decreased expression of CYP4A11 mRNA27091632
C010178heliotrineheliotrine results in decreased expression of CYP4A11 mRNA26100227
D006861Hydrogen PeroxideCYP4A11 protein results in increased abundance of Hydrogen Peroxide25061110
C040920isoliquiritigenin"isoliquiritigenin inhibits the reaction [CYP4A11 protein results in increased secretion of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]"23747687
C040920isoliquiritigeninisoliquiritigenin inhibits the reaction [CYP4A11 protein results in increased secretion of Dinoprostone]23747687
C040920isoliquiritigeninisoliquiritigenin results in decreased expression of CYP4A11 mRNA23747687|2509402
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CYP4A11 mRNA24297863
C030358lauric acidCYP4A11 protein results in increased metabolism of lauric acid16712844
C052901lemongrass oillemongrass oil affects the expression of CYP4A11 mRNA25976427
D008727MethotrexateMethotrexate results in increased expression of CYP4A11 mRNA17400583
C503100N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamideN-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide results in decreased activity of CYP4A11 protein15831442
C433446N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidineN-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine results in decreased expression of CYP4A11 mRNA26558470
C433446N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidineN-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine results in decreased expression of CYP4A11 protein26558470
C464660obeticholic acidobeticholic acid results in increased expression of CYP4A11 mRNA27939613
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid results in increased expression of CYP4A11 mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of CYP4A11 mRNA23567314
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of CYP4A11 mRNA23602845
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of CYP4A11 mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYP4A11 mRNA27153767
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of CYP4A11 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP4A11 mRNA19407336|2356731
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CYP4A11 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased activity of CYP4A11 protein8602878
D015232DinoprostoneCYP4A11 protein results in increased secretion of Dinoprostone23747687
D015232Dinoprostoneisoliquiritigenin inhibits the reaction [CYP4A11 protein results in increased secretion of Dinoprostone]23747687
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP4A11 mRNA19952500
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP4A11 mRNA19084549
D010695PhlorhizinPhlorhizin results in increased expression of CYP4A11 mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of CYP4A11 protein11101007
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of CYP4A11 mRNA26100227
D015474IsotretinoinIsotretinoin results in decreased expression of CYP4A11 mRNA15982314
C009237senecioninesenecionine results in decreased expression of CYP4A11 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of CYP4A11 mRNA26100227
D012839SimazineSimazine results in increased expression of CYP4A11 protein9711812
D014212TretinoinTretinoin inhibits the reaction [Bezafibrate results in increased expression of CYP4A11 mRNA]16712844
D014212TretinoinTretinoin metabolite results in decreased expression of CYP4A11 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of CYP4A11 mRNA16712844
D014212TretinoinTretinoin results in decreased expression of CYP4A11 protein16712844
D014800VitalliumVitallium analog results in decreased expression of CYP4A11 mRNA23825117
D014801Vitamin AVitamin A affects the activity of CYP4A11 protein8602878
C574123walrycin Awalrycin A results in increased expression of CYP4A11 mRNA22314385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0008392arachidonic acid epoxygenase activity-IDA9618440  
GO:0018685alkane 1-monooxygenase activity-IDA18433732  
GO:0020037heme binding-IEA-  
GO:0050051leukotriene-B4 20-monooxygenase activity-IDA9799565  
GO ID GO Term Qualifier Evidence PubMed
GO:0001676long-chain fatty acid metabolic process-IDA18433732  
GO:0003091renal water homeostasis-IEP10660572  
GO:0003095pressure natriuresis-IEP10660572  
GO:0006631fatty acid metabolic process-TAS-  
GO:0006691leukotriene metabolic process-IDA9799565  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0019369arachidonic acid metabolic process-IDA10660572  
GO:0019373epoxygenase P450 pathway-IDA9618440  
GO:0032305positive regulation of icosanoid secretion-IMP18391101  
GO:0036101leukotriene B4 catabolic process-IEA-  
GO:0055078sodium ion homeostasis-IEP10660572  
GO:0055114oxidation-reduction process-IDA9618440  9799565  18433732  
GO:0097267omega-hydroxylase P450 pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA10660572  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016324apical plasma membrane-IDA10660572  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA9618440  9799565  10660572  
KEGG ID KEGG Term
hsa00071Fatty acid degradation
hsa00590Arachidonic acid metabolism
hsa00830Retinol metabolism
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211935Fatty acidsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-211979EicosanoidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2142816Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28534704Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population. (2017)Zhang HClin Exp Hypertens
23085321Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China. (2013 Jan 10)Fu ZGene
24164311CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population. (2014)Yang HClin Exp Hypertens
23846787Differential expression of cytochrome P450 omega-hydroxylase isoforms and their association with clinicopathological features in pancreatic ductal adenocarcinoma. (2013 Dec)Gandhi AVAnn Surg Oncol