Gene: CYP4B1

1580
CYPIVB1|P-450HP
cytochrome P450 family 4 subfamily B member 1
protein-coding
1p33
Ensembl:ENSG00000142973 MIM:124075 Vega:OTTHUMG00000007984 UniprotKB:P13584
NG_007939.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.343e-1 (AD)  9.772e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANXA30.679
FKBP50.645
OMD0.636
TMEM2040.623
ATP10A0.615
CLEC4E0.615
SLC16A10.614
MATN30.611
SLC52A30.607
VWF0.607

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.425
FLRT1-0.412
EPHB3-0.411
KCNJ14-0.404
ST8SIA2-0.404
KCNG1-0.396
PRLHR-0.395
CYP1A1-0.391
WNT7A-0.382
VWC2-0.377

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00152ThiamineSmall Molecule70-16-6Approved|Investigational|NutraceuticalEnzyme
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitEnzyme
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CYP4B1"27234499
C0067181,12-benzoperylene"2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1,12-benzoperylene results in increased expression of CYP4B1]"27234499
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CYP4B1 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP4B1 mRNA"20566336
C0010422',3-dimethyl-4-aminobiphenyl"CYP4B1 protein results in increased metabolism of 2',3-dimethyl-4-aminobiphenyl"9310344
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of CYP4B1 mRNA"25710175
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CYP4B1 mRNA25088246
C0121772-aminofluoreneCYP4B1 protein results in increased metabolism of 2-aminofluorene18713828
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide"2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1,12-benzoperylene results in increased expression of CYP4B1]"27234499
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP4B1 mRNA"23196670
C0933833-methylbenzaldehyde3-methylbenzaldehyde affects the activity of CYP4B1 protein12791539
C0422893-methylbenzyl alcohol3-methylbenzyl alcohol results in decreased activity of CYP4B1 protein12791539
C0977453-methyleneindolenine[CYP4B1 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine20187624
C0312853-xylene3-xylene affects the activity of CYP4B1 protein15204773
C0312853-xylene3-xylene results in decreased activity of CYP4B1 protein12791539|8598570
C0014704-ipomeanolCYP4B1 gene mutant form results in decreased susceptibility to 4-ipomeanol23748241
C0014704-ipomeanolCYP4B1 protein results in increased susceptibility to and results in increased metabolism of and results in increased activity of 4-ipomeanol23748241
C0014704-ipomeanolCYP4B1 protein results in increased activity of 4-ipomeanol15892579
C0014704-ipomeanolCYP4B1 protein affects the metabolism of 4-ipomeanol8248926
C0014704-ipomeanolCYP4B1 protein results in increased susceptibility to 4-ipomeanol8248926
C0460947-chlorobenz(a)anthracene7-chlorobenz(a)anthracene results in increased expression of CYP4B1 mRNA23358148
D000082AcetaminophenAcetaminophen results in decreased expression of CYP4B1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CYP4B1 mRNA17562736
D0150812-NaphthylamineCYP4B1 protein results in increased metabolism of 2-Naphthylamine9310344
D0150812-NaphthylamineCYP4B1 protein results in increased metabolism of 2-Naphthylamine9310344
D0150812-NaphthylamineCYP4B1 protein results in increased metabolism of 2-Naphthylamine18713828
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYP4B1 mRNA16483693
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CYP4B1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CYP4B1 mRNA23912714
C029876benzidineCYP4B1 protein results in increased metabolism of benzidine18713828
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CYP4B1 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of CYP4B1 mRNA16985168|2225856
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP4B1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP4B1 mRNA22228805|2373587
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of CYP4B1 mRNA17404688
D004958EstradiolEstradiol results in decreased expression of CYP4B1 mRNA14664709
D004958EstradiolEstradiol results in decreased expression of CYP4B1 mRNA26945725
C095105bexarotenebexarotene analog results in increased expression of CYP4B1 mRNA28689802
D001629BezafibrateBezafibrate affects the expression of CYP4B1 mRNA17719200
C099952bifenthrinbifenthrin results in decreased expression of CYP4B1 mRNA26071804
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CYP4B1 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of CYP4B1 mRNA26496021
D002065BuspironeBuspirone results in increased expression of CYP4B1 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CYP4B1 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CYP4B1 mRNA11958953
D019256Cadmium ChlorideCadmium Chloride affects the expression of CYP4B1 mRNA22110744
D002110CaffeineCaffeine results in increased expression of CYP4B1 mRNA18444173
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CYP4B1 mRNA16239168
D002922CiguatoxinsCiguatoxins affects the expression of CYP4B1 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in increased expression of CYP4B1 mRNA24386269
D003300CopperCopper results in increased expression of CYP4B1 mRNA22465980
D003471CuprizoneCuprizone results in decreased expression of CYP4B1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of CYP4B1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CYP4B1 mRNA28628672
D0151013,3'-Dichlorobenzidine"CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine"9310344
D0151013,3'-Dichlorobenzidine"lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine]"9310344
D0151013,3'-Dichlorobenzidine"CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine"9310344
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of CYP4B1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of CYP4B1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CYP4B1 mRNA17917374
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA18544905
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA18253720
D004052Diethylnitrosamine[Mastic Resin co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA18977376
D002117CalcitriolCalcitriol results in decreased expression of CYP4B1 mRNA27107558
C024629dimethyl phthalatedimethyl phthalate results in increased expression of CYP4B1 mRNA26924002
C109476epoxiconazoleepoxiconazole results in increased expression of CYP4B1 mRNA25182419
D000431EthanolEthanol results in decreased expression of CYP4B1 mRNA15353170
D000431EthanolEthanol results in increased expression of CYP4B1 mRNA23273579
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CYP4B1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP4B1 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CYP4B1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP4B1 mRNA16174780|1735126
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CYP4B1 mRNA23649840
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA18253720
D005419FlavonoidsFlavonoids results in decreased expression of CYP4B1 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of CYP4B1 mRNA24136188
D019833GenisteinGenistein results in decreased expression of CYP4B1 mRNA18444173
C071834glycidamideglycidamide results in decreased expression of CYP4B1 mRNA17822822
C453899GW 7647GW 7647 results in increased expression of CYP4B1 mRNA22465071
D002112CalcifediolCalcifediol deficiency results in decreased expression of CYP4B1 mRNA17293106
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CYP4B1 mRNA28628672
C051890irinotecanirinotecan affects the expression of CYP4B1 mRNA20097248
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CYP4B1 mRNA28628672
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CYP4B1 mRNA17917374
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA18544905
C030358lauric acid"lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine]"9310344
D064704LevofloxacinLevofloxacin results in increased expression of CYP4B1 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP4B1 mRNA"20371263
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CYP4B1 mRNA25613284
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYP4B1 mRNA26378955
D000069997Mastic Resin[Mastic Resin co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA18977376
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CYP4B1 mRNA23273579
D012862SkatoleCYP4B1 protein results in increased metabolism of Skatole20187624
D012862Skatole[CYP4B1 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine20187624
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CYP4B1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of CYP4B1 promoter"26251327
D015735MifepristoneMifepristone results in decreased expression of CYP4B1 mRNA17584828
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of CYP4B1 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of CYP4B1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYP4B1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYP4B1 mRNA"25554681|2562005
D019829NevirapineNevirapine metabolite results in increased expression of CYP4B1 mRNA23947594
C570897NSC668394NSC668394 results in increased expression of CYP4B1 mRNA27137931
C108709oleoyl-estroneoleoyl-estrone results in increased expression of CYP4B1 mRNA17725831
D009966OrphenadrineOrphenadrine affects the expression of CYP4B1 mRNA23665939
D010098OxycodoneOxycodone results in increased expression of CYP4B1 mRNA23439660
D010126OzoneOzone results in decreased expression of CYP4B1 mRNA16183385
D000073878Palm OilPalm Oil results in decreased expression of CYP4B1 mRNA18042831
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of CYP4B1 mRNA19617454
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYP4B1 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP4B1 mRNA16221955|2851185
D010634PhenobarbitalPhenobarbital affects the expression of CYP4B1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of CYP4B1 mRNA12082028|2327357
C006253pirinixic acidpirinixic acid results in decreased expression of CYP4B1 mRNA18467677
C006253pirinixic acidpirinixic acid results in increased expression of CYP4B1 mRNA17426115|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP4B1 mRNA]18467677
D010936Plant ExtractsPlant Extracts results in decreased expression of CYP4B1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of CYP4B1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CYP4B1 mRNA15596064
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of CYP4B1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of CYP4B1 mRNA17404688
D019438RitonavirRitonavir affects the expression of CYP4B1 mRNA17719200
D019438RitonavirRitonavir results in decreased expression of CYP4B1 mRNA17719200
C089730rosiglitazonerosiglitazone results in increased expression of CYP4B1 mRNA21515302
D012643SeleniumSelenium deficiency results in increased expression of CYP4B1 mRNA11444866
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CYP4B1 mRNA22300531
D012906SmokeSmoke results in decreased expression of CYP4B1 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of CYP4B1 gene28589171
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYP4B1 mRNA26378955
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP4B1 mRNA"20371263
D013629TamoxifenTamoxifen affects the expression of CYP4B1 mRNA17555576
C011363terephthalic acidterephthalic acid results in increased expression of CYP4B1 mRNA16673812
C501413tesaglitazartesaglitazar results in increased expression of CYP4B1 mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of CYP4B1 mRNA26496021
D013739TestosteroneTestosterone results in increased expression of CYP4B1 mRNA11311483
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP4B1 mRNA16985168|2010694
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CYP4B1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP4B1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP4B1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP4B1 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CYP4B1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CYP4B1 mRNA27189315
D014050TolueneToluene affects the expression of CYP4B1 mRNA18653662
D014212TretinoinTretinoin results in decreased expression of CYP4B1 mRNA16985168
D014212TretinoinTretinoin results in increased expression of CYP4B1 mRNA16249480
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CYP4B1 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of CYP4B1 mRNA21515302
D017973Tungsten CompoundsTungsten Compounds results in increased expression of CYP4B1 mRNA28666766
C112106UAB 30UAB 30 analog results in increased expression of CYP4B1 mRNA23292798
C025643vinclozolinvinclozolin affects the expression of CYP4B1 mRNA19015723
C574123walrycin Awalrycin A results in increased expression of CYP4B1 mRNA22314385
D015032ZincZinc deficiency results in decreased expression of CYP4B1 mRNA12672911
D015032ZincZinc deficiency results in increased expression of CYP4B1 mRNA11717422
D015032ZincZinc results in increased expression of CYP4B1 mRNA17074742
D015034Zinc OxideZinc Oxide analog results in increased expression of CYP4B1 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in increased expression of CYP4B1 mRNA17074742
C088658zoledronic acidzoledronic acid results in increased expression of CYP4B1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0015643toxic substance binding-IEA-  
GO:0018585fluorene oxygenase activity-IEA-  
GO:0019825oxygen binding-TAS2574990  
GO:0020037heme binding-IEA-  
GO:0070330aromatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0018879biphenyl metabolic process-IEA-  
GO:0018917fluorene metabolic process-IEA-  
GO:0042738exogenous drug catabolic process-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211935Fatty acidsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-211979EicosanoidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
8694864Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. (1996 Jul 26)Hakkola JBiochem Pharmacol
19040121Detection of cytochrome P450-2A6, -3A5 and -4B1 with real-time polymerase chain reaction in prostate tissue. (2008 Sep-Oct)Zencir SZ Naturforsch C
8313365Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. (1994 Feb 15)Czerwinski MCancer Res
8619884Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. (1996 Feb 23)Hakkola JBiochem Pharmacol
9493761Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. (1998 Jan)Hakkola JCrit Rev Toxicol
27189315The human placental proteome is affected by maternal smoking. (2016 Aug)Huuskonen PReprod Toxicol
21791872Association between cancer risk and drug-metabolizing enzyme gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) polymorphisms in cases of lung cancer in Japan. (2011)Tamaki YDrug Metab Pharmacokinet