Gene: CYP7A1

1581
CP7A|CYP7|CYPVII
cytochrome P450 family 7 subfamily A member 1
protein-coding
8q12.1
Ensembl:ENSG00000167910 MIM:118455 Vega:OTTHUMG00000164301 UniprotKB:P22680
NG_007969.1
PubMed
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.975e-1 (AD)  9.881e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LHCGR0.527
C4orf170.482
MEDAG0.475
SMR3A0.475
OR6X10.451
CST9L0.447
PRKAA10.44
BORA0.439
SLC16A60.439
PIBF10.427

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FZD9-0.238
SLC27A5-0.237
LHPP-0.231
S100A1-0.221
SLC25A48-0.22
FOXO4-0.213
MPST-0.211
OLIG1-0.207
APOA1-0.206
HES6-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4668001-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane"1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane results in increased activity of CYP7A1 protein"15254889
C4668001-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane"1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane results in increased expression of CYP7A1 mRNA"15254889
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene binds to and affects the activity of NR1I3 protein] which results in increased expression of CYP7A1 mRNA"26984780
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]"19196849
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CYP7A1 mRNA"15629111|2135444
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP7A1 mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]"19196849
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]28549656
C02581320-hydroxycholesterolCYP7A1 protein results in increased metabolism of 20-hydroxycholesterol10882719
C02581320-hydroxycholesterolCYP7A1 protein results in increased metabolism of 20-hydroxycholesterol10882719
C02581320-hydroxycholesterolCYP7A1 protein results in increased metabolism of 20-hydroxycholesterol10882719
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYP7A1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYP7A1 mRNA"20056577|2729130
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C0600802,2-bis(bromomethyl)-1,3-propanediol"2,2-bis(bromomethyl)-1,3-propanediol results in increased expression of CYP7A1 mRNA"24273086
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP7A1 mRNA"25768209
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP7A1 protein"25768209
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP7A1 mRNA"28433925
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA"23756648
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CYP7A1 mRNA"21346803
C04456324-hydroxycholesterolCYP7A1 protein results in increased metabolism of 24-hydroxycholesterol11013305
C04456324-hydroxycholesterolCYP7A1 protein results in increased metabolism of 24-hydroxycholesterol11013305
C00799725-hydroxycholesterolCYP7A1 protein results in increased metabolism of 25-hydroxycholesterol10882719
C00799725-hydroxycholesterolCYP7A1 protein results in increased metabolism of 25-hydroxycholesterol10882719
C00799725-hydroxycholesterolCYP7A1 protein results in increased metabolism of 25-hydroxycholesterol10882719
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CYP7A1 mRNA"20406850
C07699627-hydroxycholesterolCYP7A1 protein results in increased metabolism of 27-hydroxycholesterol10882719
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased activity of CYP7A1 protein14614521
C07699627-hydroxycholesterolCYP7A1 protein results in increased metabolism of 27-hydroxycholesterol10882719
C07699627-hydroxycholesterolCYP7A1 protein results in increased metabolism of 27-hydroxycholesterol10882719
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP7A1 mRNA"23146750
C5131183,6-dihydroxy-7-fluorocholanoic acid"3,6-dihydroxy-7-fluorocholanoic acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]"16487557
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of CYP7A1 mRNA18544908
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of CYP7A1 mRNA20932894
C0167057-dehydrocholesterol7-dehydrocholesterol results in decreased activity of CYP7A1 protein1175606
C0030017-ketocholesterol7-ketocholesterol results in decreased activity of CYP7A1 protein1175606
C0030017-ketocholesterol7-ketocholesterol results in decreased activity of CYP7A1 protein11013305
D000082AcetaminophenAcetaminophen affects the expression of CYP7A1 mRNA15030884|1756273
D000082AcetaminophenAcetaminophen results in decreased expression of CYP7A1 mRNA18544908
D000082AcetaminophenAcetaminophen results in decreased expression of CYP7A1 mRNA15120968|1720276
D020106AcrylamideAcrylamide results in increased expression of CYP7A1 mRNA15749267
C096064acteinactein results in increased expression of CYP7A1 mRNA19527300
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYP7A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP7A1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP7A1 mRNA19770486
C008088alfacalcidolalfacalcidol results in increased expression of CYP7A1 mRNA19581390
C526957alisol B 23-acetatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]25655198
C526957alisol B 23-acetatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]25655198
C526957alisol B 23-acetate"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]]"25655198
C103303alitretinoinalitretinoin results in decreased expression of CYP7A1 mRNA15629111
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CYP7A1 mRNA21298039
C103505AM 251AM 251 inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA]23894352
D000638AmiodaroneAmiodarone results in decreased expression of CYP7A1 mRNA19224547
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYP7A1 mRNA16483693
D000924Anticholesteremic AgentsAnticholesteremic Agents results in increased expression of CYP7A1 mRNA28275691
D001151Arsenic[APOE protein affects the susceptibility to Arsenic] which affects the expression of CYP7A1 mRNA22719926
D017636Asbestos, Amphibole"Asbestos, Amphibole affects the expression of CYP7A1 protein"20855422
D001205Ascorbic Acid[Diethylnitrosamine co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA17917374
D001205Ascorbic Acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA17917374
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of CYP7A1 mRNA25278499
D001280AtrazineAtrazine results in increased expression of CYP7A1 mRNA22515965
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of CYP7A1 mRNA22258563
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP7A1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CYP7A1 mRNA22374506
D004958EstradiolEstradiol results in decreased expression of CYP7A1 mRNA20106945
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CYP7A1 mRNA28392238
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CYP7A1 mRNA28392238
D001629BezafibrateBezafibrate results in decreased activity of CYP7A1 protein2044640
D001629BezafibrateBezafibrate results in decreased expression of CYP7A1 mRNA14685799
D001629BezafibrateBezafibrate results in decreased activity of CYP7A1 protein9653895
D001629BezafibrateBezafibrate results in decreased activity of CYP7A1 protein2044640
D001647Bile Acids and SaltsBile Acids and Salts analog results in decreased expression of CYP7A1 mRNA15145977
D001647Bile Acids and SaltsCYP7A1 protein results in increased abundance of Bile Acids and Salts2744357
D001647Bile Acids and SaltsCYP7A1 protein results in increased chemical synthesis of Bile Acids and Salts15696852
D001647Bile Acids and Salts[[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts23287313
D001647Bile Acids and SaltsBile Acids and Salts affects the expression of CYP7A110809780
D001647Bile Acids and SaltsCYP7A1 protein affects the chemical synthesis of Bile Acids and Salts16213224
D001647Bile Acids and SaltsCYP7A1 protein results in increased chemical synthesis of Bile Acids and Salts10809780
D001647Bile Acids and SaltsCYP7A1 protein results in increased abundance of Bile Acids and Salts2407297
D001647Bile Acids and SaltsBile Acids and Salts results in decreased expression of CYP7A1 mRNA20699090
D001647Bile Acids and Salts[[Bile Acids and Salts results in increased activity of NR0B2 protein] co-treated with [Bile Acids and Salts results in decreased activity of HNF4A protein]] results in decreased expression of CYP7A1 mRNA20699090
D001647Bile Acids and SaltsCYP7A1 protein results in increased chemical synthesis of Bile Acids and Salts12029625|1281507
D001647Bile Acids and Salts[CYP7A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts12700418
D001663BilirubinBilirubin results in decreased activity of CYP7A1 protein12700418
D001663Bilirubin[Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein12700418
C006780bisphenol Abisphenol A results in decreased expression of CYP7A1 mRNA23146750
C006780bisphenol Abisphenol A results in increased expression of CYP7A1 mRNA17706920|2750257
C006780bisphenol ALHB protein affects the reaction [bisphenol A results in increased expression of CYP7A1 mRNA]17706920
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP7A1 mRNA"28433925
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA"23756648
C006780bisphenol Abisphenol A results in decreased expression of CYP7A1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CYP7A1 mRNA18958704
C066327BRL 39924ABRL 39924A results in increased activity of CYP7A1 protein2242032
D001966BromineBromine results in decreased expression of CYP7A1 mRNA21391292
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CYP7A1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYP7A1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYP7A1 mRNA19224547
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of CYP7A1 mRNA15629111
D002635Chenodeoxycholic Acid[Chenodeoxycholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA17963371
D002635Chenodeoxycholic Acid[Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA17963371
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of CYP7A1 mRNA19072826|2505596
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of CYP7A1 mRNA19072826|2067129
D002635Chenodeoxycholic AcidNR1H4 mutant form inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of CYP7A1 mRNA]19072826
D002635Chenodeoxycholic Acid[Chenodeoxycholic Acid results in increased expression of FGF19 protein] which results in decreased expression of CYP7A1 protein20835427
D048271ChitosanChitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]28987369
D048271ChitosanFish Oils promotes the reaction [Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]]28987369
C035377chlorendic acidchlorendic acid results in increased expression of CYP7A1 mRNA24273086
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased activity of CYP7A1 protein1175606
D002738ChloroquineChloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]28275691
D002738ChloroquineCYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]28275691
D020355CholatesCholates results in decreased expression of CYP7A1 mRNA14684751
D020355CholatesCholates results in decreased expression of CYP7A110809780
C011724cholest-5-en-3 beta,7 alpha-diol"[Uranyl Nitrate results in decreased activity of CYP7A1 protein] which results in decreased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol"20362056
C011724cholest-5-en-3 beta,7 alpha-diol"[CYP7A1 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol"11514559
D002777CholestanolsCholestanols analog results in decreased expression of CYP7A1 mRNA15145977
D002784CholesterolCYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of EIF4EBP1 protein]28275691
D002784CholesterolCYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of GSK3B protein]28275691
D002784CholesterolCYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6 protein]28275691
D002784CholesterolCYP7A1 protein affects the metabolism of Cholesterol15696852
D002784CholesterolCYP7A1 protein results in increased metabolism of Cholesterol11013305|7925343
D002784Cholesterol[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in decreased abundance of Cholesterol23287313
D002784Cholesterol[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol23287313
D002784Cholesterol[[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts23287313
D002784CholesterolCholesterol results in increased expression of CYP7A1 mRNA21535835
D002784CholesterolCYP7A1 protein results in increased metabolism of Cholesterol1175606
D002784Cholesterolturmeric extract promotes the reaction [Cholesterol results in increased expression of CYP7A1 mRNA]21535835
D002784CholesterolCYP7A1 protein results in increased metabolism of Cholesterol12700418
D002784Cholesterol[CYP7A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts12700418
D002784Cholesterol"[CYP7A1 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol"11514559
D002791Cholesterol, Dietary"Cholesterol, Dietary affects the expression of CYP7A1"10809780
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of CYP7A1 mRNA"28549616
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of CYP7A1 protein"28549616
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of CYP7A1"14684380
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of CYP7A1"14684380
D002791Cholesterol, Dietary"[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased activity of CYP7A1 protein"14684380
D002791Cholesterol, Dietary"[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased expression of CYP7A1 mRNA"14684380
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of CYP7A1 mRNA"14684380
D019826Cholic AcidCholic Acid results in decreased expression of CYP7A1 mRNA25055961
D019826Cholic Acid[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA22540009
D019826Cholic AcidCholic Acid results in decreased expression of CYP7A1 mRNA12072388|1569493
D019826Cholic Acid"[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased activity of CYP7A1 protein"14684380
D019826Cholic Acid"[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased expression of CYP7A1 mRNA"14684380
D002793Cholic Acids[Cyclosporine results in decreased expression of CYP7A1 protein] which affects the abundance of Cholic Acids26198044
C027113chrysophanic acidchrysophanic acid results in increased expression of CYP7A1 mRNA28161596
C027113chrysophanic acidchrysophanic acid results in increased expression of CYP7A1 protein28161596
D002922CiguatoxinsCiguatoxins affects the expression of CYP7A1 mRNA18353800
C553724ciklavitciklavit inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 mRNA]23287313
C553724ciklavitciklavit results in increased expression of CYP7A1 mRNA23287313
C553724ciklavit[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in decreased abundance of Cholesterol23287313
C553724ciklavit[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol23287313
C553724ciklavit[[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts23287313
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of CYP7A1 mRNA19000754
D002994ClofibrateClofibrate results in decreased expression of CYP7A1 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of CYP7A1 mRNA28973556
D002994ClofibrateClofibrate results in decreased expression of CYP7A1 mRNA19224547
D003022ClotrimazoleClotrimazole results in decreased expression of CYP7A1 mRNA15629111
D003035CobaltCobalt results in increased expression of CYP7A1 mRNA22147119
D003300CopperCopper results in decreased expression of CYP7A1 mRNA17205981
D003300CopperCopper deficiency results in increased expression of CYP7A1 mRNA11110846
D003300CopperCopper results in decreased activity of CYP7A1 protein1175606
D019327Copper SulfateCopper Sulfate results in decreased expression of CYP7A1 mRNA19549813
D003314Corn OilCorn Oil affects the expression of CYP7A1 mRNA16360708
C030123coumarincoumarin results in decreased expression of CYP7A1 mRNA18480146
D016572CyclosporineCyclosporine results in decreased expression of CYP7A1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of CYP7A1 protein26198044
D016572Cyclosporine[Cyclosporine results in decreased expression of CYP7A1 protein] which affects the abundance of Cholic Acids26198044
D016572CyclosporineCyclosporine results in increased expression of CYP7A1 mRNA19770486
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of CYP7A1 mRNA29038839
D003543CysteamineCysteamine results in increased activity of CYP7A1 protein1175606
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of CYP7A1 mRNA14684751|2505596
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of CYP7A1 mRNA20671298|2191471
D003840Deoxycholic Acid[Deoxycholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA22531947
D003840Deoxycholic AcidSLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in decreased expression of CYP7A1 mRNA]21914718
D003840Deoxycholic AcidCYP7A1 protein results in increased export of Deoxycholic Acid8245718
D003840Deoxycholic AcidDeoxycholic Acid results in decreased activity of CYP7A1 protein1175606
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CYP7A1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of CYP7A1 mRNA15629111
D003907Dexamethasone[Mifepristone co-treated with Dexamethasone] results in decreased expression of CYP7A1 mRNA15629111
D003907DexamethasoneDexamethasone results in decreased expression of CYP7A1 mRNA20888898
D003907DexamethasoneDexamethasone results in increased expression of CYP7A1 mRNA15965953
D016264Dextran SulfateDextran Sulfate results in decreased expression of CYP7A1 mRNA27580383
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CYP7A1 mRNA16382202
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CYP7A1 mRNA28962523
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CYP7A1 mRNA28392238
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CYP7A1 mRNA28392238
D004008DiclofenacDiclofenac results in increased expression of CYP7A1 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of CYP7A1 mRNA28302478
D004041Dietary Fatsciklavit inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 mRNA]23287313
D004041Dietary FatsDietary Fats results in decreased expression of CYP7A1 mRNA23287313
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]"19467301
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of CYP7A1 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of CYP7A1 mRNA18292748|2501614
D004041Dietary FatsDietary Fats results in increased expression of CYP7A1 mRNA19467301|2375664
D004041Dietary FatsFGF15 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 mRNA]28673684
D004041Dietary FatsOligosaccharides promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]28549616
D004041Dietary FatsOligosaccharides promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein]28549616
D004041Dietary Fats[Sodium Cholate co-treated with Dietary Fats] results in decreased expression of CYP7A1 mRNA23665937
D004041Dietary Fats"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA"23756648
D004041Dietary FatsChitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]28987369
D004041Dietary FatsDietary Fats results in increased expression of CYP7A1 mRNA23524313|2898736
D004041Dietary Fatsfisetin inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]23524313
D004041Dietary FatsFish Oils inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]28987369
D004041Dietary FatsFish Oils promotes the reaction [Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]]28987369
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of CYP7A1 mRNA28433925
D004051Diethylhexyl Phthalate[APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate] which results in decreased expression of CYP7A1 protein25270622
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CYP7A1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CYP7A1 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP7A1 mRNA"28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA"23756648
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA17917374
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA17917374
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA17917374
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP7A1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CYP7A1 mRNA18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP7A1 mRNA]18691550
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA16158176
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA14656948
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CYP7A1 mRNA19638242
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA18253720
D002117Calcitriol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
D002117Calcitriol[Calcitriol binds to and results in increased activity of VDR protein] promotes the reaction [VDR protein binds to CYP7A1 promoter]19106115
D002117Calcitriol[Calcitriol binds to and results in increased activity of VDR protein] which results in decreased expression of CYP7A1 mRNA19106115
D002117CalcitriolCalcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 promoter]19106115
D002117CalcitriolCalcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 promoter]19106115
D002117CalcitriolCalcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 promoter]19106115
D002117CalcitriolCalcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 promoter]19106115
D002117CalcitriolCalcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 promoter]19106115
D002117CalcitriolCalcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol promotes the reaction [VDR protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol results in decreased expression of CYP7A1 mRNA20371703
D002117Calcitriol[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]20371703
D002117Calcitriol[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in decreased expression of CYP7A1 mRNA19106115|2037170
D002117CalcitriolCSK protein promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
D002117CalcitriolNCOR1 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
D002117CalcitriolNCOR2 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
D002117CalcitriolOkadaic Acid promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
D002117Calcitriolsaracatinib inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA]]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA]]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP7A1 mRNA]]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of CYP7A1 mRNA25270620
D004144Diosgenin[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of CYP7A1 mRNA12963437
D004229DithiothreitolDithiothreitol results in increased activity of CYP7A1 protein1175606
C070609EMD 53998EMD 53998 analog results in increased expression of CYP7A1 mRNA24977338
D004642EmodinEmodin results in decreased expression of CYP7A1 mRNA28161596
D004642EmodinEmodin results in decreased expression of CYP7A1 protein28161596
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP7A1 mRNA26159488
D004726EndosulfanEndosulfan results in decreased expression of CYP7A1 mRNA26159488
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of CYP7A1 mRNA23146761
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of CYP7A1 protein23146761
C031365epomediolepomediol results in increased activity of CYP7A1 protein10961725|1147352
C031365epomediolepomediol results in increased expression of CYP7A1 mRNA11473529
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of CYP7A1 mRNA29038839
D000431EthanolAM 251 inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA]23894352
D000431EthanolEthanol results in increased expression of CYP7A1 mRNA19167417|2389435
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of CYP7A1 mRNA17347304
D004997Ethinyl EstradiolESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]29112739
D004997Ethinyl EstradiolESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]16606610
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP7A1 mRNA16606610|2781822
D004997Ethinyl EstradiolSRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]27818225
D004997Ethinyl Estradiol"3,6-dihydroxy-7-fluorocholanoic acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]"16487557
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of CYP7A1 mRNA12963437
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased activity of CYP7A1 protein11473529|9869655
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP7A1 mRNA16487557|1710823
D004997Ethinyl EstradiolUrsodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]16487557
C024565ethylene dichlorideethylene dichloride results in decreased expression of CYP7A1 mRNA28189721
C504383fenbuconazolefenbuconazole results in decreased expression of CYP7A1 mRNA15942997
D011345FenofibrateFenofibrate results in decreased expression of CYP7A1 mRNA14685799
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA18253720
C017875fisetinfisetin inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]23524313
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of CYP7A1 mRNA17347304
D005395Fish OilsFish Oils inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]28987369
D005395Fish OilsFish Oils promotes the reaction [Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]]28987369
D005419FlavonoidsFlavonoids results in increased expression of CYP7A1 mRNA18035473
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA16158176
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA14656948
D005485FlutamideFlutamide results in decreased expression of CYP7A1 mRNA24136188
D015378Imipenem[Vancomycin co-treated with Imipenem] results in decreased expression of CYP7A1 mRNA24657338
C039281furanfuran results in decreased expression of CYP7A1 mRNA15120968
C039281furanfuran results in increased expression of CYP7A1 mRNA25539665
D015248GemfibrozilGemfibrozil results in decreased expression of CYP7A1 mRNA14685799
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CYP7A1 mRNA21782745
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [resveratrol results in increased expression of CYP7A1 mRNA]22607622
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]23894352
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]23894352
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA23894352
C094503glyceryl 2-arachidonateINS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]23894352
C094503glyceryl 2-arachidonateINS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]23894352
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA23894352
D006002Glycodeoxycholic AcidGlycodeoxycholic Acid results in decreased expression of CYP7A1 mRNA24994853
D019695Glycyrrhizic AcidGlycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]28549656
D019695Glycyrrhizic AcidGlycyrrhizic Acid results in decreased expression of CYP7A1 mRNA22982774
C473027GW 3965GW 3965 results in increased expression of CYP7A1 mRNA17420776
C412815GW 4064FGFR4 protein affects the reaction [[GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA]22467244
C412815GW 4064[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA22540009
C412815GW 4064GW 4064 results in decreased expression of CYP7A1 mRNA27609522
C412815GW 4064[GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA22467244
C412815GW 4064GW 4064 results in decreased expression of CYP7A1 mRNA14623915|1564443
C010178heliotrineheliotrine results in decreased expression of CYP7A1 mRNA26100227
D006888HydroxycholesterolsHydroxycholesterols results in increased expression of CYP7A115629111
C001654hyperforinhyperforin results in decreased expression of CYP7A1 mRNA24259679
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in decreased activity of CYP7A1 protein10656290
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA17917374
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA17917374
D007854LeadLead affects the expression of CYP7A122001170
D007854LeadLead results in decreased activity of CYP7A1 protein1175606
D007854Leadpuerarin affects the reaction [Lead affects the expression of CYP7A1]22001170
C017461lead nitrate[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]22293356
C017461lead nitratelead nitrate results in decreased expression of CYP7A1 mRNA16049268|2229335
C017461lead nitratelead nitrate results in decreased expression of CYP7A1 mRNA15475176
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CYP7A1 mRNA"18930950
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNA22777745
D008095Lithocholic Acid[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA17963371
D008095Lithocholic Acid[Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA17963371
D008095Lithocholic AcidLithocholic Acid results in decreased expression of CYP7A1 mRNA25055961
D008095Lithocholic Acid"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]"19196849
D008095Lithocholic AcidLithocholic Acid results in decreased expression of CYP7A1 mRNA16436656|1919684
D008095Lithocholic Acid[Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA22531947
D008095Lithocholic Acid"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]"19196849
D008095Lithocholic AcidPregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]20359477
D008095Lithocholic AcidCYP7A1 protein results in increased export of Lithocholic Acid8245718
D008095Lithocholic AcidLithocholic Acid results in decreased activity of CYP7A1 protein1175606
D008095Lithocholic AcidLithocholic Acid results in decreased expression of CYP7A1 mRNA20888898
C502354lithocholic acid acetate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C502354lithocholic acid acetateCSK protein promotes the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C502354lithocholic acid acetate[lithocholic acid acetate binds to and results in increased activity of VDR protein] which results in decreased expression of CYP7A1 mRNA19106115
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [HNF4A protein binds to CYP7A1 promoter]19106115
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [NCOA2 protein binds to CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [NCOA2 protein binds to CYP7A1 promoter]19106115
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [PPARGC1A protein binds to CYP7A1 promoter]19106115
C502354lithocholic acid acetatelithocholic acid acetate promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate promotes the reaction [NCOR1 protein binds to CYP7A1 promoter]19106115
C502354lithocholic acid acetatelithocholic acid acetate promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate promotes the reaction [NCOR2 protein binds to CYP7A1 promoter]19106115
C502354lithocholic acid acetatelithocholic acid acetate promotes the reaction [VDR protein binds to CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate results in decreased expression of CYP7A1 mRNA20371703
C502354lithocholic acid acetate[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]20371703
C502354lithocholic acid acetate[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] which results in decreased expression of CYP7A1 mRNA20371703
C502354lithocholic acid acetateNCOR1 protein promotes the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
C502354lithocholic acid acetateNCOR2 protein promotes the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
C502354lithocholic acid acetateOkadaic Acid promotes the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C502354lithocholic acid acetatesaracatinib inhibits the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C502354lithocholic acid acetateU 0126 inhibits the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
D008345Manganese[Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein12700418
D008345ManganeseManganese results in increased activity of CYP7A1 protein12700418
D008623MercaptoethanolMercaptoethanol results in increased activity of CYP7A1 protein1175606
D008628MercuryMercury results in decreased activity of CYP7A1 protein1175606
D008727MethotrexateMethotrexate results in decreased expression of CYP7A1 mRNA24449571
D008727MethotrexateMethotrexate results in decreased expression of CYP7A1 mRNA15120968
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CYP7A1 mRNA21782745
D008730MethoxsalenMethoxsalen results in decreased expression of CYP7A1 mRNA28552422
D008730MethoxsalenMethoxsalen results in increased expression of CYP7A1 protein28552422
D015735Mifepristone[Mifepristone co-treated with Dexamethasone] results in decreased expression of CYP7A1 mRNA15629111
D015735MifepristoneMifepristone results in decreased expression of CYP7A1 mRNA15629111
D016686Monocrotaline[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA21224054
C500085muraglitazarmuraglitazar results in increased expression of CYP7A1 mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CYP7A1 mRNA"29244179
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of CYP7A1 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CYP7A1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYP7A1 mRNA"25620056
D0150581-Naphthylisothiocyanate18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]28549656
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA25655198|2785383
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein25655198
D0150581-Naphthylisothiocyanatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]25655198
D0150581-Naphthylisothiocyanatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]25655198
D0150581-NaphthylisothiocyanateGlycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]28549656
D0150581-Naphthylisothiocyanate"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]]"25655198
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA14623915|2412042
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein25418378
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CYP7A1 mRNA20551477|2636556
D0150581-Naphthylisothiocyanateresveratrol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]25418378
D0150581-Naphthylisothiocyanateresveratrol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]25418378
D009532NickelNickel results in increased expression of CYP7A1 mRNA18922574
C464660obeticholic acidobeticholic acid results in decreased expression of CYP7A1 mRNA15911693|2793961
C464660obeticholic acidobeticholic acid results in decreased expression of CYP7A1 mRNA15644430
D019319Okadaic AcidOkadaic Acid promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
D019319Okadaic AcidOkadaic Acid promotes the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
D009828Oleanolic AcidOleanolic Acid results in decreased expression of CYP7A1 mRNA23948738
D009828Oleanolic AcidOleanolic Acid results in decreased expression of CYP7A1 protein23948738
D009844OligosaccharidesOligosaccharides promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]28549616
D009844OligosaccharidesOligosaccharides promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein]28549616
D000069463Olive OilOlive Oil analog affects the expression of CYP7A1 mRNA17349074
C016340o,p'-DDT"o,p'-DDT affects the expression of CYP7A1 mRNA"18925944
D009966OrphenadrineOrphenadrine affects the expression of CYP7A1 mRNA23665939
D010100OxygenOxygen deficiency results in decreased expression of CYP7A1 mRNA19695866
D017239PaclitaxelPaclitaxel results in decreased expression of CYP7A1 mRNA15585946
D010416PentachlorophenolPentachlorophenol results in increased expression of CYP7A1 mRNA23892564
C108042perfluorobutaneperfluorobutane results in decreased expression of CYP7A1 mRNA23567314
C033094perfluorobutyric acidperfluorobutyric acid analog results in increased expression of CYP7A1 mRNA21878386
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of CYP7A1 mRNA23567314
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of CYP7A1 mRNA27344344
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of CYP7A1 mRNA23567314
C036567perfluorodecanoic acidPPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]27344344
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of CYP7A1 mRNA23567314
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of CYP7A1 mRNA23567314
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of CYP7A1 mRNA23567314
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of CYP7A1 mRNA21705711|2356731
C479228perfluorohexanoic acidperfluorohexanoic acid results in decreased expression of CYP7A1 mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of CYP7A1 mRNA23567314
C584865perfluorononanoic acidperfluorononanoic acid results in decreased expression of CYP7A1 mRNA29112762
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of CYP7A1 mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA27153767
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA19429403|2093613
C076994perfluorooctane sulfonic acidPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA]20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA16221955|1869254
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP7A1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP7A1 mRNA23567314|2715376
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP7A1 mRNA17681415|1942940
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CYP7A1 mRNA]20936131
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of CYP7A1 mRNA17097637
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP7A1 mRNA15629111
D010634PhenobarbitalPhenobarbital affects the expression of CYP7A1 mRNA15629111
D010634PhenobarbitalPhenobarbital results in increased expression of CYP7A1 mRNA22258563
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP7A1 mRNA24535843
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP7A1 mRNA15629111
D010634PhenobarbitalPhenobarbital results in increased expression of CYP7A1 mRNA19270015
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP7A1 mRNA19162173
D010672Phenytoin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA21224054
D010713PhosphatidylcholinesPhosphatidylcholines results in increased activity of CYP7A1 protein12559476
C060836pioglitazonepioglitazone promotes the reaction [U 0126 results in increased expression of CYP7A1 mRNA]22593575
C060836pioglitazonepioglitazone results in increased expression of CYP7A1 mRNA22593575
C060836pioglitazoneU 0126 promotes the reaction [pioglitazone results in increased expression of CYP7A1 mRNA]22593575
C006253pirinixic acidpirinixic acid results in decreased expression of CYP7A1 mRNA15629111
C006253pirinixic acidpirinixic acid results in decreased expression of CYP7A1 mRNA15777286|1844570
C006253pirinixic acidpirinixic acid results in increased expression of CYP7A1 mRNA20936131
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of CYP7A1 mRNA]15777286
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP7A1 mRNA]20059764|2093613
D059808PolyphenolsPolyphenols results in increased expression of CYP7A1 mRNA16293270
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]"12705905
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]]"25655198
D011284PregnenolonePregnenolone results in decreased activity of CYP7A1 protein1175606
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]20359477
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CYP7A1 mRNA15629111|2298277
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CYP7A1 mRNA19162173
C045950propiconazolepropiconazole results in increased expression of CYP7A1 mRNA21278054
C033607puerarinpuerarin affects the reaction [Lead affects the expression of CYP7A1]22001170
C496788PX-866[PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA25805502
D011718PyrazinamidePyrazinamide results in increased expression of CYP7A1 mRNA27255380
D011718PyrazinamidePyrazinamide results in increased expression of CYP7A1 protein27255380
C031280pyrazolepyrazole results in decreased expression of CYP7A1 mRNA17945193
C010423pyrithione zincpyrithione zinc results in increased expression of CYP7A1 mRNA21424779
D011759PyrrolidinesPyrrolidines analog results in decreased expression of CYP7A1 mRNA26365562
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of CYP7A1 mRNA26100227
C059514resveratrolgeranylgeranyl pyrophosphate inhibits the reaction [resveratrol results in increased expression of CYP7A1 mRNA]22607622
C059514resveratrolNR1H3 protein promotes the reaction [resveratrol results in increased expression of CYP7A1 mRNA]22607622
C059514resveratrol[resveratrol results in increased activity of NR1H3 protein] which results in increased expression of CYP7A1 mRNA22607622
C059514resveratrolresveratrol results in increased expression of and results in increased activity of CYP7A1 protein22607622
C059514resveratrolresveratrol results in increased expression of CYP7A1 mRNA22607622|2314656
C059514resveratrolresveratrol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]25418378
C059514resveratrolresveratrol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]25418378
D012293RifampinNR1I2 protein promotes the reaction [Rifampin results in decreased expression of CYP7A1 mRNA]21127053
D012293RifampinRifampin results in decreased expression of CYP7A1 mRNA15629111|2112705
D012293Rifampin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA21224054
C042734rifaximin[NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7A1 protein22790967
D019438RitonavirRitonavir results in decreased expression of CYP7A1 mRNA26626330
D019438RitonavirRitonavir results in decreased expression of CYP7A1 mRNA17719200
C089730rosiglitazonerosiglitazone results in decreased expression of CYP7A1 mRNA25572481
C089730rosiglitazonerosiglitazone results in increased expression of CYP7A1 mRNA21515302
C515233saracatinibsaracatinib inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
C515233saracatinibsaracatinib inhibits the reaction [CSK protein results in decreased expression of CYP7A1 mRNA]20371703
C515233saracatinibsaracatinib inhibits the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C515233saracatinibsaracatinib results in increased expression of CYP7A1 mRNA20371703
C009237senecioninesenecionine results in decreased expression of CYP7A1 mRNA26100227
C009237senecioninesenecionine results in decreased expression of CYP7A1 mRNA24641316
C009238senkirkinesenkirkine results in decreased expression of CYP7A1 mRNA26100227
C009250sevofluranesevoflurane affects the expression of CYP7A1 mRNA15967596
C009277sodium arsenatesodium arsenate results in decreased expression of CYP7A1 mRNA23922661
C016104sodium bichromatesodium bichromate results in increased expression of CYP7A1 mRNA12325037
D020358Sodium Cholate[Sodium Cholate co-treated with Dietary Fats] results in decreased expression of CYP7A1 mRNA23665937
D013024Soybean OilSoybean Oil results in increased activity of CYP7A1 protein12559476
D013148SpironolactoneSpironolactone results in decreased activity of CYP7A1 protein15652244
C075117squalestatin 1squalestatin 1 results in decreased expression of CYP7A1 mRNA15629111
C525422SRT1720SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]27818225
D013261Sterols[ATP7B gene mutant form results in decreased expression of CYP7A1 protein] which affects the metabolism of Sterols17303181
D013311StreptozocinStreptozocin results in increased expression of CYP7A1 mRNA10393316
D013629TamoxifenTamoxifen affects the expression of CYP7A1 mRNA20937368
D013629TamoxifenTamoxifen results in decreased expression of CYP7A1 mRNA19224547
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of CYP7A1 mRNA]21079772
D013656Taurocholic AcidFGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of CYP7A1 mRNA]16284190
D013656Taurocholic AcidNR1H4 protein affects the reaction [Taurocholic Acid results in decreased expression of CYP7A1 mRNA]16284190
D013656Taurocholic AcidTaurocholic Acid results in decreased expression of CYP7A1 mRNA16284190
D013656Taurocholic AcidTaurocholic Acid results in decreased expression of CYP7A1 mRNA7832767
C501413tesaglitazartesaglitazar results in decreased expression of CYP7A1 mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of CYP7A1 mRNA21669218
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP7A1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNA20106945
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP7A1 mRNA"28433925
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA"23756648
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP7A1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNA19770486|2184647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP7A1 mRNA21095216
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNA16054898|2121527
D013752TetracyclineTetracycline results in increased expression of CYP7A1 mRNA16917069
D013752TetracyclineTetracycline results in decreased expression of CYP7A1 mRNA19224547
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CYP7A1 mRNA16979875
D013853ThioacetamideThioacetamide results in increased expression of CYP7A1 mRNA26222700
C423915TO-901317TO-901317 results in increased expression of CYP7A1 mRNA23591747
D014050TolueneToluene affects the expression of CYP7A1 mRNA18653662
D014212TretinoinTretinoin results in increased expression of CYP7A1 mRNA15629111
D014212TretinoinTretinoin promotes the reaction [Ursodeoxycholic Acid results in decreased expression of CYP7A1 mRNA]21274875
D014212TretinoinTretinoin results in decreased expression of CYP7A1 mRNA21274875
D014212TretinoinUrsodeoxycholic Acid promotes the reaction [Tretinoin results in decreased expression of CYP7A1 mRNA]21274875
D014212Tretinoin[Tretinoin co-treated with Ursodeoxycholic Acid] results in decreased expression of CYP7A1 mRNA21274875
D014212TretinoinTretinoin results in increased expression of CYP7A1 mRNA24977338
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CYP7A1 mRNA25549359
D014241TrichloroethyleneTrichloroethylene results in increased expression of CYP7A1 mRNA19254012
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CYP7A1 gene27618143
D014303TrinitrotolueneTrinitrotoluene affects the expression of CYP7A1 mRNA21346803
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of CYP7A1 mRNA26898711
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP7A1 mRNA"24273086
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of CYP7A1 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of CYP7A1 mRNA19631733
C057693troglitazonetroglitazone results in increased expression of CYP7A1 mRNA21515302
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CYP7A1 mRNA"18930950
C012596turmeric extractturmeric extract promotes the reaction [Cholesterol results in increased expression of CYP7A1 mRNA]21535835
C113580U 0126U 0126 inhibits the reaction [Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]]20371703
C113580U 0126U 0126 inhibits the reaction [Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]]20371703
C113580U 0126U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA]]20371703
C113580U 0126U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]]20371703
C113580U 0126U 0126 inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA]]20371703
C113580U 0126U 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP7A1 mRNA]]20371703
C113580U 0126U 0126 inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
C113580U 0126U 0126 inhibits the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C113580U 0126pioglitazone promotes the reaction [U 0126 results in increased expression of CYP7A1 mRNA]22593575
C113580U 0126U 0126 promotes the reaction [pioglitazone results in increased expression of CYP7A1 mRNA]22593575
C113580U 0126U 0126 results in increased expression of CYP7A1 mRNA22593575
C112106UAB 30UAB 30 analog results in increased expression of CYP7A1 mRNA23292798
C112106UAB 30UAB 30 results in increased expression of CYP7A1 mRNA23292798
D014502Uranyl NitrateUranyl Nitrate results in decreased activity of CYP7A1 protein20362056
D014502Uranyl Nitrate"[Uranyl Nitrate results in decreased activity of CYP7A1 protein] which results in decreased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol"20362056
D014502Uranyl NitrateUranyl Nitrate results in increased expression of CYP7A1 mRNA20362056
D014520UrethaneUrethane results in decreased expression of CYP7A1 mRNA28818685
D014580Ursodeoxycholic AcidTretinoin promotes the reaction [Ursodeoxycholic Acid results in decreased expression of CYP7A1 mRNA]21274875
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [Tretinoin results in decreased expression of CYP7A1 mRNA]21274875
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of CYP7A1 mRNA14684751|2127487
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of CYP7A1 mRNA20671298|2558270
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of CYP7A1 mRNA15452192
D014580Ursodeoxycholic Acid[Tretinoin co-treated with Ursodeoxycholic Acid] results in decreased expression of CYP7A1 mRNA21274875
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]16487557
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of CYP7A1 mRNA16764892
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNA22777745
C406224valdecoxibvaldecoxib results in decreased expression of CYP7A1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of CYP7A1 mRNA29154799
D014640Vancomycin[Vancomycin co-treated with Imipenem] results in decreased expression of CYP7A1 mRNA24657338
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CYP7A1 gene25560391
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CYP7A1 mRNA16979875
D015032ZincZinc deficiency results in increased expression of CYP7A1 mRNA18356318
D015032ZincZinc results in decreased activity of CYP7A1 protein1175606

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005506iron ion binding-IEA-  
GO:0008123cholesterol 7-alpha-monooxygenase activity-IBA21873635  
GO:0008123cholesterol 7-alpha-monooxygenase activity-ISS-  
GO:0008123cholesterol 7-alpha-monooxygenase activity-TAS-  
GO:0008395steroid hydroxylase activity-IBA21873635  
GO:0020037heme binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006699bile acid biosynthetic process-IBA21873635  
GO:0006699bile acid biosynthetic process-IDA19965590  
GO:0006699bile acid biosynthetic process-IEA-  
GO:0006699bile acid biosynthetic process-ISS-  
GO:0006699bile acid biosynthetic process-TAS-  
GO:0006707cholesterol catabolic process-ISS-  
GO:0016125sterol metabolic process-TAS-  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0042632cholesterol homeostasis-IBA21873635  
GO:0042632cholesterol homeostasis-ISS-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070857regulation of bile acid biosynthetic process-IDA19965590  
GO:0070857regulation of bile acid biosynthetic process-ISS-  
GO:0071333cellular response to glucose stimulus-IDA19965590  
GO:0071397cellular response to cholesterol-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-ISS-  
KEGG ID KEGG Term
hsa00120Primary bile acid biosynthesis
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolTAS
R-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterolTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15469403Pharmacogenomics and drug response in cardiovascular disorders. (2004 Oct)Siest GPharmacogenomics
16630139Genetic polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) and colorectal adenomas: Self Defense Forces Health Study. (2006 May)Tabata SCancer Sci
29404434Gut microbial composition can differentially regulate bile acid synthesis in humanized mice. (2017 Feb)Kang DJHepatol Commun
22969879Association between cytochrome P450 promoter polymorphisms and ischemic stroke. (2012 Feb)Kim SKExp Ther Med