Gene: TTLL11

158135
C9orf20|bA244O19.1
tubulin tyrosine ligase like 11
protein-coding
9q33.2
Ensembl:ENSG00000175764 Vega:OTTHUMG00000020597 UniprotKB:Q8NHH1
NC_000009.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.714e-1 (AD)  2.343e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16911292chr9:122019270 (GRCh38.p7)C>A / C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH3PXD2A0.861
NIPA10.827
NIPAL30.817
LDLRAD40.814
RAB11FIP40.809
KIAA1324L0.797
PEX50.796
NKAIN20.789
AGTPBP10.785
SYNJ20.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IMPA2-0.407
TMPRSS3-0.402
STK17B-0.4
DMRTA1-0.397
DDIT4L-0.393
RNF135-0.384
ADORA2B-0.378
INHBB-0.378
TNFRSF11B-0.371
PON3-0.369

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTLL11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTLL11 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TTLL11 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of TTLL11 mRNA29067470
D000638AmiodaroneAmiodarone affects the expression of TTLL11 mRNA25064622
D001280AtrazineAtrazine results in decreased expression of TTLL11 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTLL11 mRNA26001963
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TTLL11 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of TTLL11 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TTLL11 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTLL11 mRNA28628672
D002746ChlorpromazineChlorpromazine affects the expression of TTLL11 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of TTLL11 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of TTLL11 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of TTLL11 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TTLL11 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTLL11 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TTLL11 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TTLL11 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TTLL11 mRNA25064622
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of TTLL11 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of TTLL11 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTLL11 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTLL11 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TTLL11 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TTLL11 mRNA21641980
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TTLL11 mRNA21641980
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TTLL11 mRNA"20188158
D009020MorphineMorphine results in increased expression of TTLL11 mRNA21178816
D010269ParaquatParaquat affects the expression of TTLL11 mRNA25064622
C006253pirinixic acidpirinixic acid results in increased expression of TTLL11 mRNA18301758|2081375
D012402RotenoneRotenone affects the expression of TTLL11 mRNA21893155
D012402RotenoneTRP53 affects the reaction [Rotenone affects the expression of TTLL11 mRNA]21893155
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TTLL11 mRNA21641980
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TTLL11 mRNA21641980
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of TTLL11 mRNA25172293
D013752TetracyclineTetracycline affects the expression of TTLL11 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of TTLL11 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of TTLL11 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTLL11 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TTLL11 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TTLL11 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0070740tubulin-glutamic acid ligase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0018095protein polyglutamylation-TAS-  
GO:0051013microtubule severing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IEA-  
GO:0005929cilium-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8955332Carboxyterminal post-translational modifications of tubulinTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal