Gene: CYP8B1

1582
CP8B|CYP12
cytochrome P450 family 8 subfamily B member 1
protein-coding
3p22.1
Ensembl:ENSG00000180432 MIM:602172 Vega:OTTHUMG00000133047 UniprotKB:Q9UNU6
NG_007970.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.457e-1 (AD)  2.794e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR7A170.416
OR12D10.41
PTCRA0.4
C9orf430.384
CYP1A20.378
FAM186A0.373
HOXD120.372
CPB20.366
GPX60.365
NAT20.363

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C6orf222-0.232
MAP1LC3C-0.229
C16orf47-0.229
OR6T1-0.223
CCL1-0.21
KLK5-0.209
TBC1D21-0.204
MMP3-0.202
HSFY2-0.198
CHRFAM7A-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine results in decreased expression of CYP8B1 mRNA26821219
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CYP8B1 mRNA"21354444
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene binds to and affects the activity of NR1I3 protein] which results in decreased expression of CYP8B1 mRNA"26984780
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]"19196849
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CYP8B1 mRNA"28903501
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP8B1 mRNA"27413110
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]"19196849
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in decreased expression of CYP8B1 mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in decreased expression of CYP8B1 mRNA26821219
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CYP8B1 mRNA"21346803
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased activity of CYP8B1 protein14614521
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of CYP8B1 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CYP8B1 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CYP8B1 mRNA"21346803
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of CYP8B1 mRNA20932894
D000082AcetaminophenAcetaminophen results in decreased expression of CYP8B1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CYP8B1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of CYP8B1 mRNA18544908
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CYP8B1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP8B1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYP8B1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP8B1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP8B1 mRNA19770486
C526957alisol B 23-acetatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA]25655198
C526957alisol B 23-acetatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]25655198
C526957alisol B 23-acetate"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]]"25655198
C103505AM 251AM 251 inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA]23894352
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYP8B1 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of CYP8B1 mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of CYP8B1 mRNA]12205029
C030419andrographolideandrographolide results in increased expression of CYP8B1 mRNA19737545
D000924Anticholesteremic AgentsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP8B1 mRNA]28275691
D000924Anticholesteremic AgentsAnticholesteremic Agents results in increased expression of CYP8B1 mRNA28275691
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of CYP8B1 mRNA18585445
D001151ArsenicArsenic affects the methylation of CYP8B1 gene25304211
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of CYP8B1 mRNA18585445
D001280AtrazineAtrazine results in increased expression of CYP8B1 mRNA22378314
D001280AtrazineAtrazine results in decreased expression of CYP8B1 mRNA26775023
D001507BeclomethasoneBeclomethasone results in decreased expression of CYP8B1 mRNA23656298
D001554BenzeneBenzene affects the expression of CYP8B1 mRNA15878777
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of CYP8B1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP8B1 mRNA20064835|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CYP8B1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP8B1 mRNA19770486|2222880
D004958EstradiolEstradiol results in decreased expression of CYP8B1 mRNA20106945
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CYP8B1 mRNA28392238
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CYP8B1 mRNA28392238
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of CYP8B1 mRNA17630414
C006780bisphenol Abisphenol A results in increased methylation of CYP8B1 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of CYP8B1 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP8B1 mRNA22079614
D002065BuspironeBuspirone results in increased expression of CYP8B1 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CYP8B1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CYP8B1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYP8B1 mRNA27339419
D002512Cephalothin[Cephalothin co-treated with Neomycin] results in decreased expression of CYP8B1 mRNA24657338
C026690cerous chloridecerous chloride affects the expression of CYP8B1 mRNA23139204
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of CYP8B1 mRNA25055961
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of CYP8B1 mRNA25582706
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA27344345
D019826Cholic AcidCholic Acid results in decreased expression of CYP8B1 mRNA25055961
D019826Cholic AcidCholic Acid results in decreased expression of CYP8B1 mRNA17521389|2558270
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA27344345
D002793Cholic Acids[Cyclosporine results in decreased expression of CYP8B1 protein] which affects the abundance of Cholic Acids26198044
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CYP8B1 mRNA18952117
D002794CholineRXRA affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CYP8B1 mRNA]18952117
C027113chrysophanic acidchrysophanic acid results in decreased expression of CYP8B1 mRNA28161596
C027113chrysophanic acidchrysophanic acid results in decreased expression of CYP8B1 protein28161596
D002922CiguatoxinsCiguatoxins affects the expression of CYP8B1 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CYP8B1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of CYP8B1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP8B1 mRNA]17585979
D002994ClofibrateClofibrate results in increased expression of CYP8B1 mRNA10393316
D003314Corn OilCorn Oil affects the expression of CYP8B1 mRNA16360708
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of CYP8B1 mRNA17383702
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of CYP8B1 mRNA20106945|2497309
D016572CyclosporineCyclosporine results in decreased expression of CYP8B1 protein26198044
D016572Cyclosporine[Cyclosporine results in decreased expression of CYP8B1 protein] which affects the abundance of Cholic Acids26198044
D016572CyclosporineCyclosporine results in decreased expression of CYP8B1 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CYP8B1 mRNA24317228
D003671DEET[fipronil co-treated with DEET] results in decreased expression of CYP8B1 mRNA27091632
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of CYP8B1 mRNA25055961
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of CYP8B1 mRNA21914718|2558270
D003840Deoxycholic AcidSLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in decreased expression of CYP8B1 mRNA]21914718
D003907DexamethasoneDexamethasone results in decreased expression of CYP8B1 mRNA10393316
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CYP8B1 mRNA28392238
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CYP8B1 mRNA28392238
D004008DiclofenacDiclofenac results in decreased expression of CYP8B1 mRNA26934552
D004026DieldrinDieldrin results in decreased expression of CYP8B1 mRNA23153324
D004041Dietary FatsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP8B1 mRNA]28275691
D004041Dietary FatsDietary Fats affects the expression of CYP8B1 mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP8B1 mRNA28275691
D004041Dietary FatsDietary Fats results in decreased expression of CYP8B1 mRNA22609946|2501614
D004041Dietary Fats[Oligosaccharides co-treated with Dietary Fats] results in increased expression of CYP8B1 mRNA28549616
D004041Dietary Fats[Oligosaccharides co-treated with Dietary Fats] results in increased expression of CYP8B1 protein28549616
D019422Dietary SucroseAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP8B1 mRNA]28275691
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP8B1 mRNA28275691
D019422Dietary SucroseDietary Sucrose results in decreased expression of CYP8B1 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CYP8B1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CYP8B1 mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CYP8B1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP8B1 mRNA28943392
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA18253720
D004642EmodinEmodin results in decreased expression of CYP8B1 mRNA28161596
D004642EmodinEmodin results in decreased expression of CYP8B1 protein28161596
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of CYP8B1 mRNA25198161
D004726EndosulfanEndosulfan results in decreased expression of CYP8B1 mRNA26615145
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of CYP8B1 mRNA24412560
D000431EthanolAM 251 inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA]23894352
D000431EthanolEthanol results in increased expression of CYP8B1 mRNA19167417|2389435
D004997Ethinyl EstradiolESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP8B1 mRNA]16606610
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP8B1 mRNA16606610
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP8B1 mRNA17108234|9869655
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA18253720
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of CYP8B1 mRNA27091632
C082360fipronilfipronil results in decreased expression of CYP8B1 mRNA27091632
D015378Imipenem[Vancomycin co-treated with Imipenem] results in decreased expression of CYP8B1 mRNA24657338
C056933fumonisin B1fumonisin B1 results in decreased expression of CYP8B1 mRNA16221962
C049864ginsenoside Reginsenoside Re results in increased expression of CYP8B1 mRNA23835644
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]23894352
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]23894352
C412815GW 4064GW 4064 results in decreased expression of CYP8B1 mRNA14623915|1564443
C010178heliotrineheliotrine results in decreased expression of CYP8B1 mRNA26100227
D017313FenretinideFenretinide results in decreased expression of CYP8B1 mRNA28973697
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA18544905
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP8B1 mRNA"20371263
D008095Lithocholic Acid"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]"19196849
D008095Lithocholic AcidLithocholic Acid results in decreased expression of CYP8B1 mRNA16436656|1919684
D008095Lithocholic Acid"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]"19196849
D008095Lithocholic AcidNR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]19196849
D008095Lithocholic AcidPhenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]19196849
D008095Lithocholic AcidPregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]20359477
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CYP8B1 mRNA18952117
D008715MethionineRXRA affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CYP8B1 mRNA]18952117
D008730MethoxsalenMethoxsalen results in decreased expression of CYP8B1 mRNA28552422
C500085muraglitazarmuraglitazar results in increased expression of CYP8B1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYP8B1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYP8B1 mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA25655198
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein25655198
D0150581-Naphthylisothiocyanatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA]25655198
D0150581-Naphthylisothiocyanatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]25655198
D0150581-Naphthylisothiocyanate"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]]"25655198
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA14623915|2412042
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of CYP8B1 mRNA26821219
C051752nefazodonenefazodone results in increased expression of CYP8B1 mRNA24136188
D009355Neomycin[Cephalothin co-treated with Neomycin] results in decreased expression of CYP8B1 mRNA24657338
C464660obeticholic acidobeticholic acid results in increased expression of CYP8B1 mRNA27939613
C464660obeticholic acidobeticholic acid results in decreased expression of CYP8B1 mRNA15644430
D009828Oleanolic AcidOleanolic Acid results in decreased expression of CYP8B1 mRNA23948738
D009828Oleanolic AcidOleanolic Acid results in decreased expression of CYP8B1 protein23948738
D009844Oligosaccharides[Oligosaccharides co-treated with Dietary Fats] results in increased expression of CYP8B1 mRNA28549616
D009844Oligosaccharides[Oligosaccharides co-treated with Dietary Fats] results in increased expression of CYP8B1 protein28549616
D009966OrphenadrineOrphenadrine affects the expression of CYP8B1 mRNA23665939
D010126OzoneOzone results in decreased expression of CYP8B1 mRNA16183385
D000073878Palm OilPalm Oil affects the expression of CYP8B1 mRNA19680557
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of CYP8B1 mRNA27344344
C584865perfluorononanoic acidperfluorononanoic acid results in decreased expression of CYP8B1 mRNA29112762
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of CYP8B1 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP8B1 mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP8B1 mRNA28511854
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP8B1 mRNA19084549
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CYP8B1 mRNA]19482888
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]19196849
D010634PhenobarbitalPhenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]19196849
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP8B1 mRNA19482888
C008905physcionephyscione results in decreased expression of CYP8B1 mRNA28161596
C008905physcionephyscione results in decreased expression of CYP8B1 protein28161596
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of CYP8B1 mRNA22484513
C006253pirinixic acidpirinixic acid results in decreased expression of CYP8B1 mRNA19176532
C006253pirinixic acidpirinixic acid results in increased expression of CYP8B1 mRNA15777286|1622196
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of CYP8B1 mRNA]15777286
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]]"25655198
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]20359477
D011718PyrazinamidePyrazinamide results in decreased expression of CYP8B1 mRNA27255380
D011718PyrazinamidePyrazinamide results in decreased expression of CYP8B1 protein27255380
C031280pyrazolepyrazole results in decreased expression of CYP8B1 mRNA17945193
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of CYP8B1 mRNA26100227
D011794QuercetinQuercetin results in decreased expression of CYP8B1 mRNA21632981
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of CYP8B1 mRNA25905778
C059514resveratrolresveratrol results in increased expression of CYP8B1 mRNA25905778
C059514resveratrolStreptozocin inhibits the reaction [resveratrol results in increased expression of CYP8B1 mRNA]25905778
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in decreased expression of CYP8B1 mRNA21127053
D012312RitodrineRitodrine results in decreased expression of CYP8B1 mRNA23370008
D019438RitonavirRitonavir results in decreased expression of CYP8B126626330
D019438RitonavirRitonavir results in decreased expression of CYP8B1 mRNA17719200
C089730rosiglitazonerosiglitazone affects the expression of CYP8B1 mRNA21515302
D012643SeleniumSelenium deficiency results in increased expression of CYP8B1 mRNA16170372
D012643SeleniumSelenium results in increased expression of CYP8B1 mRNA16170372
C009237senecioninesenecionine results in decreased expression of CYP8B1 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of CYP8B1 mRNA26100227
C009277sodium arsenatesodium arsenate results in decreased expression of CYP8B1 mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of CYP8B1 mRNA25993096
D013311StreptozocinINS1 protein inhibits the reaction [Streptozocin results in increased expression of CYP8B1 mRNA]10393316
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of CYP8B1 mRNA25905778
D013311StreptozocinStreptozocin inhibits the reaction [resveratrol results in increased expression of CYP8B1 mRNA]25905778
D013311StreptozocinStreptozocin results in increased expression of CYP8B1 mRNA10393316|2590577
D013311StreptozocinStreptozocin results in increased expression of CYP8B1 protein10393316
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP8B1 mRNA"20371263
D014284TriiodothyronineTriiodothyronine results in decreased expression of CYP8B1 mRNA10393316
C013698tallowtallow affects the expression of CYP8B1 mRNA19680557
D013629TamoxifenTamoxifen results in decreased expression of CYP8B1 mRNA25123088
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of CYP8B1 mRNA17630414
C501413tesaglitazartesaglitazar results in increased expression of CYP8B1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA20106945
D013749TetrachlorodibenzodioxinNFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA]21846477
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CYP8B1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP8B1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA21846477|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA21724226
D013752TetracyclineTetracycline results in decreased expression of CYP8B1 mRNA24489787
D013752TetracyclineTetracycline results in increased expression of CYP8B1 mRNA16917069
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP8B1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of CYP8B1 mRNA26222700
D013974ThyroxineThyroxine results in decreased expression of CYP8B1 mRNA10393316
D014050TolueneToluene affects the expression of CYP8B1 mRNA18653662
C032910triadimefontriadimefon results in decreased expression of CYP8B1 mRNA16730040
C057693troglitazonetroglitazone results in increased expression of CYP8B1 mRNA21515302
C080163trovafloxacintrovafloxacin results in increased expression of CYP8B1 mRNA24136188
D014415TunicamycinTunicamycin results in decreased expression of CYP8B1 mRNA17127020
D014520UrethaneUrethane results in decreased expression of CYP8B1 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of CYP8B1 mRNA25582706
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of CYP8B1 mRNA16764892
C406224valdecoxibvaldecoxib results in decreased expression of CYP8B1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of CYP8B1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of CYP8B1 mRNA24489787
D014640Vancomycin[Vancomycin co-treated with Imipenem] results in decreased expression of CYP8B1 mRNA24657338
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CYP8B1 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of CYP8B1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005506iron ion binding-IEA-  
GO:0008397sterol 12-alpha-hydroxylase activity-IBA21873635  
GO:0019825oxygen binding-TAS10051404  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:00337787alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006699bile acid biosynthetic process-TAS-  
GO:0016125sterol metabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00120Primary bile acid biosynthesis
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolTAS
R-HSA-193775Synthesis of bile acids and bile salts via 24-hydroxycholesterolTAS
R-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterolTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-196807Nicotinate metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-197264Nicotinamide salvagingTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-211979EicosanoidsTAS
R-HSA-211994Sterols are 12-hydroxylated by CYP8B1TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29404434Gut microbial composition can differentially regulate bile acid synthesis in humanized mice. (2017 Feb)Kang DJHepatol Commun