Gene: SAXO1

158297
C9orf138|FAM154A
stabilizer of axonemal microtubules 1
protein-coding
9p22.1
Ensembl:ENSG00000155875 MIM:616292 Vega:OTTHUMG00000019609 UniprotKB:Q8IYX7
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.895e-1 (AD)  8.394e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7030400chr9:19014647 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of SAXO1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SAXO1 gene28505145
D019422Dietary SucroseDietary Sucrose results in increased expression of SAXO1 mRNA26033743
D019284ThapsigarginThapsigargin results in increased expression of SAXO1 mRNA22378314
D014635Valproic AcidValproic Acid results in increased methylation of SAXO1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23088713  25416956  25910212  26871637  27107014  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IDA25673876  
GO ID GO Term Qualifier Evidence PubMed
GO:0009631cold acclimation-IDA25673876  
GO:0030030cell projection organization-IEA-  
GO:0034453microtubule anchoring-IBA21873635  
GO:0045724positive regulation of cilium assembly-IMP25673876  
GO:0050821protein stabilization-IDA25673876  
GO:0070417cellular response to cold-IDA25673876  
GO ID GO Term Qualifier Evidence PubMed
GO:0005814centriole-IBA21873635  
GO:0005814centriole-IDA25673876  
GO:0005856cytoskeleton-IBA21873635  
GO:0005879axonemal microtubule-IBA21873635  
GO:0005879axonemal microtubule-IDA25673876  
GO:0031514motile cilium-IBA21873635  
GO:0031514motile cilium-IDA25673876  
GO:0036064ciliary basal body-IBA21873635  
GO:0036064ciliary basal body-IDA25673876  
GO:0036126sperm flagellum-IBA21873635  
GO:0036126sperm flagellum-IDA25673876  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal