Gene info: ID 1583

Gene: CYP11A1

GENE ID: 1583

Synonyms: CYP11A|CYPXIA1|P450SCC

Description: cytochrome P450 family 11 subfamily A member 1

Gene type: protein-coding

Location: 15q24.1

dbXrefs: Ensembl:ENSG00000140459 MIM:118485 Vega:OTTHUMG00000150716 UniprotKB:P05108

RefSeq: NG_007973.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.625e-1 (AD) 6.374e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg05939495	chr15:74660110	CYP11A1	Promoter	4.590e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ACSF2	0.865
HOGA1	0.861
FAH	0.854
PLCD1	0.842
ERBB2	0.838
ACSS3	0.837
STK33	0.836
STON2	0.835
CHDH	0.833
SMO	0.832

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OSBPL10	-0.573
GABRG3	-0.568
MCHR1	-0.553
KCNK9	-0.552
FHL2	-0.544
SLC36A1	-0.541
CALHM1	-0.54
EPHA5	-0.539
IL12RB2	-0.538
KCNS2	-0.536

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C495657	1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	"1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane results in decreased expression of CYP11A1 mRNA"	20840852
C003582	11-hydroxyandrostenedione	11-hydroxyandrostenedione results in decreased expression of CYP11A1 mRNA	15858796
C524478	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole	"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]"	18511507
C524478	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole	"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]"	18511507
C524478	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole	"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]"	18511507
C524478	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole	"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]"	18511507
C524478	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole	"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of CYP11A1 protein]]"	18511507
C524478	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole	"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]"	18511507
C524478	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole	"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]"	18511507
C033489	1,3-dichloro-2-propanol	"1,3-dichloro-2-propanol results in decreased expression of CYP11A1 mRNA"	24518350
C512457	17,20-dihydroxyvitamin D2	"CYP11A1 protein results in increased chemical synthesis of 17,20-dihydroxyvitamin D2"	24382416
C539020	1alpha,20-dihydroxyvitamin D3	"CYP11A1 protein results in increased hydroxylation of 1alpha,20-dihydroxyvitamin D3"	19000766
C539020	1alpha,20-dihydroxyvitamin D3	"[CYP11A1 protein results in increased hydroxylation of alfacalcidol] which results in increased chemical synthesis of 1alpha,20-dihydroxyvitamin D3"	19000766
C055238	1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene	"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with LHB protein] results in decreased expression of CYP11A1 mRNA"	23333615
C055238	1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene	"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene results in decreased expression of CYP11A1 mRNA"	23333615
C033729	1H,1H,2H,2H-perfluorodecanol	"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 mRNA"	20615422
C033729	1H,1H,2H,2H-perfluorodecanol	"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 protein"	20615422
C025813	20-hydroxycholesterol	[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA	21610156
C512456	20-hydroxyvitamin D2	CYP11A1 protein results in increased chemical synthesis of 20-hydroxyvitamin D2	24382416
C120129	2,2',3,4',5',6-hexachlorobiphenyl	"2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP11A1 mRNA"	16216300
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether metabolite results in decreased expression of CYP11A1 mRNA"	18248924
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of CYP11A1 mRNA"	18248924
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of and results in decreased activity of CYP11A1 protein"	22867812
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYP11A1 mRNA"	22867812
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone results in decreased expression of CYP11A1 protein"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"THRA mutant form inhibits the reaction [2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]"	21726595
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the activity of CYP11A1 protein"	15336722
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP11A1 protein]"	21664964
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [CGB3 protein results in increased activity of CYP11A1 protein]"	21664964
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]"	16737795\|1941451
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP11A1 protein"	16199348\|1806519
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"[2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP11A1 protein] which results in decreased chemical synthesis of Progesterone"	21664964
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of CYP11A1 mRNA"	10684797
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CYP11A1 mRNA"	19114083
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of CYP11A1 mRNA"	17447562
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of CYP11A1 mRNA"	25818047
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of CYP11A1 mRNA"	25818047
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP11A1 protein"	16151981
C009828	2,4,5,2',5'-pentachlorobiphenyl	"2,4,5,2',5'-pentachlorobiphenyl metabolite results in increased expression of CYP11A1 mRNA"	16216300
C009828	2,4,5,2',5'-pentachlorobiphenyl	"2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP11A1 mRNA"	16216300
C004554	2,4,6-tribromophenol	"2,4,6-tribromophenol results in increased expression of CYP11A1 mRNA"	17447562
C024564	2,4,6-trichlorophenol	"2,4,6-trichlorophenol results in decreased expression of CYP11A1 mRNA"	21296122
C013930	2,4-dibromophenol	"2,4-dibromophenol results in increased expression of CYP11A1 mRNA"	17447562
C104450	25-hydroxyvitamin D	25-hydroxyvitamin D deficiency results in decreased expression of CYP11A1 mRNA	28655646
C104450	25-hydroxyvitamin D	25-hydroxyvitamin D deficiency results in decreased expression of CYP11A1 protein	28655646
C014953	2-acetyltributylcitrate	2-acetyltributylcitrate results in increased expression of CYP11A1 mRNA	28235592
C032038	2-bromophenol	2-bromophenol results in increased expression of CYP11A1 mRNA	17447562
C032790	3,3',4,4',5,5'-hexabromobiphenyl	"3,3',4,4',5,5'-hexabromobiphenyl results in increased expression of CYP11A1 mRNA"	17447562
C036685	3,3',4,4'-tetrabromobiphenyl	"3,3',4,4'-tetrabromobiphenyl results in increased expression of CYP11A1 mRNA"	17447562
C041525	3,3',4,5'-tetrahydroxystilbene	"3,3',4,5'-tetrahydroxystilbene results in decreased expression of CYP11A1 mRNA"	24610083
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP11A1 mRNA"	12781204
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP11A1 protein"	16151981
C030103	3,5-diiodothyronine	"3,5-diiodothyronine affects the reaction [LHB protein affects the expression of CYP11A1 mRNA]"	21798688
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of CYP11A1 mRNA	22841810
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CYP11A1 mRNA"	18648102
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of CYP11A1 mRNA"	25723718
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CYP11A1 mRNA"	22504055
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CYP11A1 protein"	22504055
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of CYP11A1 protein"	27567155
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]"	21826657
C116322	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine	[4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine co-treated with CGA protein] results in increased expression of CYP11A1 mRNA	21352547
C116322	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine results in decreased expression of CYP11A1 mRNA	21352547
C116322	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine results in decreased expression of CYP11A1 protein	21352547
C041594	4-nonylphenol	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA	29029336
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of CYP11A1 mRNA	17696135\|2902933
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of CYP11A1 protein	17696135
C105260	4-tert-octylphenol	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA	29029336
D000079	Acetaldehyde	[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of CYP11A1 mRNA	22285649
C464485	acetamiprid	acetamiprid results in decreased expression of CYP11A1 mRNA	28395332
C464485	acetamiprid	acetamiprid results in decreased expression of CYP11A1 protein	28395332
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of CYP11A1 mRNA]	26769589
D020106	Acrylamide	Acrylamide results in decreased expression of CYP11A1 mRNA	15749267
D020106	Acrylamide	Acrylamide results in increased expression of CYP11A1 mRNA	22459607
D000242	Cyclic AMP	Cyclic AMP results in increased expression of CYP11A1 mRNA	25576683\|2866861
D000242	Cyclic AMP	myricetin promotes the reaction [Cyclic AMP results in increased expression of CYP11A1 mRNA]	28668616
D000242	Cyclic AMP	quercetin pentaacetate promotes the reaction [Cyclic AMP results in increased expression of CYP11A1 mRNA]	28668616
D000242	Cyclic AMP	Quercetin promotes the reaction [Cyclic AMP results in increased expression of CYP11A1 mRNA]	28668616
D000324	Adrenocorticotropic Hormone	Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA	16410306
D000324	Adrenocorticotropic Hormone	beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]	16410306
D000324	Adrenocorticotropic Hormone	resveratrol inhibits the reaction [beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]]	16410306
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CYP11A1 protein	24373827
C031143	AICA ribonucleotide	AICA ribonucleotide affects the reaction [FSHB protein results in increased expression of CYP11A1 protein]	16837613
C031143	AICA ribonucleotide	AICA ribonucleotide results in increased expression of CYP11A1 protein	16837613\|1747807
C008088	alfacalcidol	CYP11A1 protein results in increased hydroxylation of alfacalcidol	19000766
C008088	alfacalcidol	"[CYP11A1 protein results in increased hydroxylation of alfacalcidol] which results in increased chemical synthesis of 1alpha,20-dihydroxyvitamin D3"	19000766
C103303	alitretinoin	alitretinoin results in increased expression of CYP11A1 mRNA	19744992
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of CYP11A1 mRNA	22948218
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of CYP11A1 protein	22948218
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of CYP11A1 mRNA	21273442
D013196	Dihydrotestosterone	FSHB protein inhibits the reaction [Dihydrotestosterone results in decreased expression of CYP11A1 protein]	22948218
C011512	alpha-naphthoflavone	alpha-naphthoflavone results in decreased expression of CYP11A1 mRNA	15635147
C011512	alpha-naphthoflavone	[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in decreased expression of CYP11A1 mRNA	15635147
C005197	alternariol	alternariol results in decreased expression of CYP11A1 protein	19429235
D000616	Aminoglutethimide	Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]	16935330
D000616	Aminoglutethimide	Aminoglutethimide results in decreased hydroxylation of CYP11A1 protein	22341706
D017311	Amlodipine	Amlodipine results in decreased expression of CYP11A1 mRNA	11086231
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CYP11A1 mRNA	16483693
D015113	Androstane-3,17-diol	"Androstane-3,17-diol results in increased expression of CYP11A1 mRNA"	21273442
D000735	Androstenedione	Androstenedione results in increased expression of CYP11A1 mRNA	21273442
D000735	Androstenedione	bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP11A1 protein]	21273442
D000735	Androstenedione	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Androstenedione	23873838
D000735	Androstenedione	Finasteride promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]	21273442
D000735	Androstenedione	formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]	21273442
C103016	antalarmin	antalarmin results in decreased expression of CYP11A1 mRNA	16014403
D001151	Arsenic	Arsenic affects the methylation of CYP11A1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CYP11A1 mRNA	18630931
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of CYP11A1 mRNA	17901237
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Cadmium results in decreased expression of CYP11A1 mRNA]	15223132
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]	16298753
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]	17280759
C104416	astressin	astressin results in decreased expression of CYP11A1 mRNA	16014403
D001280	Atrazine	Atrazine results in increased expression of CYP11A1 mRNA	18461179\|2237831
D001280	Atrazine	NR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]	18461179
D001280	Atrazine	SGK1 protein affects the reaction [Atrazine results in increased expression of CYP11A1 mRNA]	18461179
D001280	Atrazine	Atrazine results in decreased expression of CYP11A1 mRNA	23376530\|2463210
D001280	Atrazine	Atrazine affects the expression of CYP11A1 mRNA	22674924
D001280	Atrazine	[Atrazine co-treated with Bucladesine] results in increased expression of CYP11A1 mRNA	23200735
D001280	Atrazine	[Atrazine co-treated with Colforsin] results in increased expression of CYP11A1 mRNA	25253736
D001280	Atrazine	Atrazine inhibits the reaction [Bucladesine results in increased expression of CYP11A1 mRNA]	21693180
D001280	Atrazine	Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA]	26923738
D001280	Atrazine	Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	25253736
D001280	Atrazine	Atrazine results in increased expression of CYP11A1 mRNA	21427058\|2237258
D001280	Atrazine	Atrazine results in increased expression of CYP11A1 protein	21427058
D001280	Atrazine	FSHB protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]	22372587
D001280	Atrazine	kolaviron inhibits the reaction [Atrazine affects the expression of CYP11A1 mRNA]	22674924
D001280	Atrazine	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP11A1 mRNA]	23200735
D001280	Atrazine	Quercetin inhibits the reaction [Atrazine results in increased expression of CYP11A1 mRNA]	22372587\|2320073
D001280	Atrazine	Quercetin inhibits the reaction [FSHB protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]]	22372587
D001280	Atrazine	U 0126 inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]	25253736
D001280	Atrazine	wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]	25253736
C004456	beauvericin	beauvericin results in increased expression of CYP11A1 mRNA	27474255
D001507	Beclomethasone	Beclomethasone results in increased expression of CYP11A1 mRNA	23656298
D019324	beta-Naphthoflavone	[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in decreased expression of CYP11A1 mRNA	15635147
D019324	beta-Naphthoflavone	beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]	16410306
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of CYP11A1 mRNA	15635147
D019324	beta-Naphthoflavone	resveratrol inhibits the reaction [beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]]	16410306
D001572	Benzofurans	Benzofurans results in increased expression of CYP11A1 mRNA	17447562
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYP11A1 mRNA	21737371
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYP11A1 protein	21737371
D004958	Estradiol	Estradiol results in increased expression of CYP11A1 mRNA	24223173
D004958	Estradiol	Estradiol results in increased expression of CYP11A1 mRNA	12858341
D004958	Estradiol	Estradiol results in decreased expression of CYP11A1 mRNA	14648872
D004958	Estradiol	Estradiol results in decreased expression of CYP11A1 mRNA	16311018\|1819188
D004958	Estradiol	Estradiol results in decreased expression of CYP11A1 protein	20144698
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP11A1 mRNA]	23209616
C053541	bicalutamide	bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP11A1 protein]	21273442
C053541	bicalutamide	bicalutamide inhibits the reaction [Testosterone results in increased expression of CYP11A1 protein]	21273442
C099952	bifenthrin	bifenthrin results in decreased expression of CYP11A1 mRNA	23994515\|2444916
C099952	bifenthrin	bifenthrin analog inhibits the reaction [CGA results in increased expression of CYP11A1 mRNA]	21871944
C099952	bifenthrin	bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP11A1 mRNA]	21251947
D001688	Biological Products	Biological Products results in decreased expression of CYP11A1 mRNA	26055946
C006780	bisphenol A	bisphenol A results in increased expression of CYP11A1 mRNA	26911650
C006780	bisphenol A	bisphenol A results in decreased expression of CYP11A1 mRNA	28501544
C006780	bisphenol A	bisphenol A results in increased expression of CYP11A1 mRNA	22710023
C006780	bisphenol A	bisphenol A results in increased methylation of CYP11A1 gene	28501544
C006780	bisphenol A	bisphenol A results in decreased expression of CYP11A1 mRNA	21273127\|2675112
C006780	bisphenol A	bisphenol A results in decreased expression of CYP11A1 protein	27112698
C006780	bisphenol A	bisphenol A affects the expression of CYP11A1 mRNA	21182934
C006780	bisphenol A	bisphenol A affects the expression of CYP11A1 protein	21182934\|2839307
C006780	bisphenol A	bisphenol A deficiency inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA]	23707772
C006780	bisphenol A	bisphenol A results in decreased expression of CYP11A1	26975478
C006780	bisphenol A	bisphenol A results in decreased expression of CYP11A1 mRNA	20956811\|2370777
C006780	bisphenol A	bisphenol A results in increased expression of CYP11A1 mRNA	12021184\|2112381
C006780	bisphenol A	bisphenol A results in increased expression of CYP11A1 protein	26209791\|2869742
C006780	bisphenol A	pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]	26209791\|2869742
C006780	bisphenol A	pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]	26209791
C006780	bisphenol A	bisphenol A affects the expression of CYP11A1 mRNA	26398930
C006780	bisphenol A	bisphenol A affects the expression of CYP11A1 mRNA	18191889
C006780	bisphenol A	[bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Progesterone	18191889
C006780	bisphenol A	[bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Testosterone	18191889
C006780	bisphenol A	bisphenol A results in decreased expression of CYP11A1 mRNA	15901920\|2014469
C006780	bisphenol A	bisphenol A results in decreased expression of CYP11A1 protein	20144698
C006780	bisphenol A	bisphenol A results in increased expression of CYP11A1 mRNA	23528252\|2885990
C006780	bisphenol A	bisphenol A results in increased expression of CYP11A1 protein	26209791
C000611646	bisphenol F	bisphenol F results in increased expression of CYP11A1 mRNA	28741210
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA	20147733\|2254648
D015124	8-Bromo Cyclic Adenosine Monophosphate	Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]	22546480
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA	21726595\|2401464
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein	21726595\|2474060
D015124	8-Bromo Cyclic Adenosine Monophosphate	"Hydrocarbons, Chlorinated inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]"	24740604
D015124	8-Bromo Cyclic Adenosine Monophosphate	[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA	21610156
D015124	8-Bromo Cyclic Adenosine Monophosphate	[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA	21610156
D015124	8-Bromo Cyclic Adenosine Monophosphate	"THRA mutant form inhibits the reaction [2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of CYP11A1 mRNA]]	21396343
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP11A1 protein]"	21664964
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP11A1 protein	21664964
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein	21126571
D001971	Bromocriptine	Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA]	21427058
D001971	Bromocriptine	Bromocriptine results in decreased expression of CYP11A1 protein	12742521
C027561	butylbenzyl phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA	29029336
C027561	butylbenzyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA	28013214
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in increased expression of CYP11A1 mRNA	26472102
C038091	butylparaben	butylparaben results in decreased expression of CYP11A1 mRNA	26888303
C038091	butylparaben	butylparaben results in decreased expression of CYP11A1 protein	26888303
D002104	Cadmium	Ascorbic Acid inhibits the reaction [Cadmium results in decreased expression of CYP11A1 mRNA]	15223132
D002104	Cadmium	Cadmium results in decreased expression of CYP11A1 mRNA	15223132
D002104	Cadmium	Cadmium results in decreased expression of CYP11A1 protein	25981801
C028031	cadmium acetate	[cadmium acetate co-treated with lead acetate] results in decreased expression of CYP11A1 mRNA	21182167
C028031	cadmium acetate	cadmium acetate results in decreased expression of CYP11A1 mRNA	21182167
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of CYP11A1 protein	12080015
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP11A1 mRNA	12080015
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP11A1 mRNA	19897027\|2498288
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP11A1 protein	19897027
D019256	Cadmium Chloride	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of CYP11A1 mRNA]]	21396343
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [POMC results in increased expression of CYP11A1 mRNA]	21396343
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CYP11A1 mRNA	24269906
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP11A1 mRNA	17719163
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP11A1 protein	25981801
D002110	Caffeine	Caffeine results in decreased expression of CYP11A1 mRNA	24717552\|2586884
C010059	carbamylhydrazine	carbamylhydrazine analog results in decreased expression of CYP11A1 mRNA	28834696
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA	18160741
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP11A1 mRNA	18160741
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of CYP11A1 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]	16298753
D020111	Chlorodiphenyl (54% Chlorine)	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]	17280759
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein	15808795\|1629875
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA	17280759\|1728323
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 protein	19071209\|2920848
D020111	Chlorodiphenyl (54% Chlorine)	lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 protein]	19071209
D020111	Chlorodiphenyl (54% Chlorine)	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]	16298753
D020111	Chlorodiphenyl (54% Chlorine)	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]	17280759
D002738	Chloroquine	Chloroquine results in decreased expression of CYP11A1 mRNA	19393257
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CYP11A1 mRNA	20211256
D002772	Cholera Toxin	Cholera Toxin results in increased expression of CYP11A1 mRNA	11226075
D002772	Cholera Toxin	Dichlorodiphenyl Dichloroethylene inhibits the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]	11226075
D002772	Cholera Toxin	Methoxychlor promotes the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]	11226075
D002784	Cholesterol	Cholesterol inhibits the reaction [Methoxychlor results in decreased activity of CYP11A1 protein]	8431464
D002784	Cholesterol	CYP11A1 protein affects the metabolism of Cholesterol	16054388
D002784	Cholesterol	CYP11A1 protein results in increased metabolism of Cholesterol	19900470
D002784	Cholesterol	CYP11A1 protein affects the metabolism of Cholesterol	10888668\|1619934
D002784	Cholesterol	CYP11A1 protein results in increased metabolism of Cholesterol	11226075
D002784	Cholesterol	[CYP11A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Pregnenolone	11502818
C007045	cholesteryl sulfate	cholesteryl sulfate results in decreased expression of CYP11A1 mRNA	18490834
D002953	Citrinin	Citrinin results in decreased expression of CYP11A1 protein	22564900
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CYP11A1 mRNA	22816610
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CYP11A1 mRNA	24328340
D005576	Colforsin	Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]	16935330
D005576	Colforsin	BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]	18936084
D005576	Colforsin	Colforsin affects the expression of CYP11A1 mRNA	20726872
D005576	Colforsin	Colforsin results in increased expression of CYP11A1 mRNA	14691014\|1693533
D005576	Colforsin	Lindane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]	17080404
D005576	Colforsin	Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]	16935330
D005576	Colforsin	Valproic Acid affects the reaction [Colforsin affects the expression of CYP11A1 mRNA]	20726872
D005576	Colforsin	[Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNA	26783879
D005576	Colforsin	[Atrazine co-treated with Colforsin] results in increased expression of CYP11A1 mRNA	25253736
D005576	Colforsin	Colforsin results in increased expression of CYP11A1 protein	22948218
D005576	Colforsin	RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]	22948218
D003513	Cycloheximide	Cycloheximide results in decreased expression of CYP11A1 protein	21126571
C017160	cypermethrin	cypermethrin results in decreased expression of CYP11A1 mRNA	20131380\|2156030
C004742	daidzein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA	28964809
C013908	daidzin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA	28964809
D003634	DDT	DDT results in increased expression of CYP11A1 mRNA	27894940
D003634	DDT	DDT analog results in increased expression of CYP11A1 mRNA	24213010
D003634	DDT	DDT results in increased expression of CYP11A1 mRNA	12858341
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of CYP11A1 mRNA	26602377
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of CYP11A1 protein	26602377
C007262	deoxynivalenol	deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]	17656051
D017135	Desogestrel	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA	18160741
D003907	Dexamethasone	[Dexamethasone co-treated with Dibutyl Phthalate] results in decreased expression of CYP11A1 mRNA	22615892
C526766	diaminochlorotriazine	diaminochlorotriazine results in decreased expression of CYP11A1 mRNA	24632104
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA	28104404
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA	29029336
D003993	Dibutyl Phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA	29029336
D003993	Dibutyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA	28013214
D003993	Dibutyl Phthalate	[Dexamethasone co-treated with Dibutyl Phthalate] results in decreased expression of CYP11A1 mRNA	22615892
D003993	Dibutyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate] results in decreased expression of CYP11A1	17400582
D003993	Dibutyl Phthalate	Dibutyl Phthalate inhibits the reaction [CEBPB binds to CYP11A1 promoter]	17884934
D003993	Dibutyl Phthalate	Dibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP11A1 promoter]	17884934
D003993	Dibutyl Phthalate	Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP11A1 promoter]	23358192
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA	14617579\|1514109
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CYP11A1 protein	14617579\|1514109
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CYP11A1 mRNA	26472102
D003994	Bucladesine	Bucladesine results in increased expression of CYP11A1 mRNA	21979172
D003994	Bucladesine	[Atrazine co-treated with Bucladesine] results in increased expression of CYP11A1 mRNA	23200735
D003994	Bucladesine	Atrazine inhibits the reaction [Bucladesine results in increased expression of CYP11A1 mRNA]	21693180
D003994	Bucladesine	Bucladesine results in increased expression of CYP11A1 mRNA	21693180
D003994	Bucladesine	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP11A1 mRNA]	23200735
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene inhibits the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]	11226075
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP11A1 mRNA	11226075
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA	18313992
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of CYP11A1 mRNA	26033743
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA	29029336
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CYP11A1 mRNA	25701202\|2597599
D004051	Diethylhexyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA	28013214
D004051	Diethylhexyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate] results in decreased expression of CYP11A1	17400582
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of CYP11A1 mRNA	20568448
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of CYP11A1 mRNA	23064086
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CYP11A1 mRNA	16690193\|2163311
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein	16690193
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased activity of CYP11A1 protein	12112309
D004052	Diethylnitrosamine	[nodularin co-treated with Diethylnitrosamine] results in decreased activity of CYP11A1 protein	12112309
C007379	diethyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA	28013214
C007379	diethyl phthalate	diethyl phthalate results in decreased expression of CYP11A1 mRNA	26472102
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP11A1 mRNA	18597071
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP11A1 mRNA	12858341
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP11A1 mRNA	22100434\|2897013
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP11A1 protein	22100434
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CYP11A1 mRNA	14648872
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP11A1 mRNA	22615892\|2387383
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP11A1 protein	23873838
D004054	Diethylstilbestrol	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of 17-alpha-Hydroxyprogesterone	23873838
D004054	Diethylstilbestrol	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Androstenedione	23873838
D004054	Diethylstilbestrol	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Progesterone	23873838
D004054	Diethylstilbestrol	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased chemical synthesis of Pregnenolone	23873838
C089799	diheptyl phthalate	diheptyl phthalate results in decreased expression of CYP11A1 mRNA	22112501
D002117	Calcitriol	Calcitriol results in increased expression of CYP11A1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of CYP11A1 mRNA	21592394
C025605	diisobutyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA	28013214
C025605	diisobutyl phthalate	diisobutyl phthalate results in decreased expression of CYP11A1 mRNA	21633115\|2211250
C025605	diisobutyl phthalate	diisobutyl phthalate results in decreased expression of CYP11A1 protein	16458459
C012125	diisononyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA	28013214
C012125	diisononyl phthalate	diisononyl phthalate results in decreased expression of CYP11A1 mRNA	21633115\|2211250
D004117	Dimethoate	Dimethoate results in decreased activity of CYP11A1 protein	11054639
D004117	Dimethoate	Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of CYP11A1 mRNA]	26769589
D004117	Dimethoate	Dimethoate results in decreased expression of CYP11A1 mRNA	26769589
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of CYP11A1 mRNA	26472102
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of CYP11A1 mRNA	17365614
C027387	di-n-hexyl phthalate	di-n-hexyl phthalate results in decreased expression of CYP11A1 mRNA	22112501\|2693418
C027387	di-n-hexyl phthalate	di-n-hexyl phthalate results in decreased expression of CYP11A1 protein	26934186
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in decreased expression of CYP11A1 mRNA	21177253\|2163311
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in increased expression of CYP11A1 mRNA	26472102
C034171	di-n-pentyl phthalate	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11A1 mRNA	25055962
D004147	Dioxins	Dioxins affects the expression of CYP11A1 mRNA	20463971
D004317	Doxorubicin	Doxorubicin results in increased expression of CYP11A1 mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in decreased expression of CYP11A1 mRNA	19915844
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of CYP11A1 mRNA"	14711788
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased activity of CYP11A1 protein"	17895526
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of CYP11A1 mRNA"	17895526
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of CYP11A1 protein"	17895526
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of CYP11A1 mRNA"	21899001
D060754	Equol	Equol results in decreased expression of CYP11A1 mRNA	26876617
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CYP11A1 mRNA	17606305
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CYP11A1 mRNA	22710023
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CYP11A1 mRNA	17555576\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP11A1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CYP11A1 mRNA	15858796
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CYP11A1 mRNA	15834898\|1590192
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CYP11A1 mRNA	17365614
C024565	ethylene dichloride	ethylene dichloride affects the expression of CYP11A1 mRNA	28973639
C024565	ethylene dichloride	ethylene dichloride affects the expression of CYP11A1 protein	28973639
C002994	ethylene dimethanesulfonate	[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of CYP11A1 mRNA	23064086
D015025	Zearalenone	[Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNA	26783879
D015025	Zearalenone	Zearalenone results in decreased expression of CYP11A1 mRNA	24512812
D015025	Zearalenone	Zearalenone inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]	17656051
C017690	fenvalerate	fenvalerate results in decreased activity of CYP11A1 protein	18053657
C017690	fenvalerate	fenvalerate results in decreased expression of CYP11A1 mRNA	18053657\|1968356
C017690	fenvalerate	fenvalerate results in decreased expression of CYP11A1 protein	18053657\|1968356
C017690	fenvalerate	fenvalerate results in decreased expression of CYP11A1 mRNA	15907653\|1989200
C017690	fenvalerate	fenvalerate results in decreased expression of CYP11A1 protein	15907653
C017690	fenvalerate	fenvalerate results in increased expression of CYP11A1 mRNA	16001830
D018120	Finasteride	Finasteride promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]	21273442
D018120	Finasteride	Finasteride promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA]	21273442
D005411	Flame Retardants	[Flame Retardants co-treated with CGB3 protein] results in decreased expression of CYP11A1 mRNA	23347875
D005411	Flame Retardants	Flame Retardants metabolite results in decreased expression of CYP11A1 mRNA	18248924
D005411	Flame Retardants	Flame Retardants metabolite results in increased expression of CYP11A1 mRNA	18248924
D005411	Flame Retardants	Flame Retardants results in increased expression of CYP11A1 mRNA	17447562\|2244682
D005411	Flame Retardants	Flame Retardants results in decreased expression of and results in decreased activity of CYP11A1 protein	22867812
D005411	Flame Retardants	Flame Retardants results in decreased expression of CYP11A1 mRNA	22867812
D005473	Fluoxetine	Fluoxetine results in decreased expression of CYP11A1 mRNA	26348076
D005473	Fluoxetine	resveratrol inhibits the reaction [Fluoxetine results in decreased expression of CYP11A1 mRNA]	26348076
D005485	Flutamide	Flutamide inhibits the reaction [Testosterone results in decreased expression of CYP11A1 mRNA]	22009729
D005485	Flutamide	Flutamide results in increased expression of CYP11A1 mRNA	14967917\|2152539
D005485	Flutamide	Flutamide results in increased expression of CYP11A1 protein	21525395
D005557	Formaldehyde	Formaldehyde results in decreased expression of CYP11A1 mRNA	28937961
C014594	formestane	formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]	21273442
C014594	formestane	formestane promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA]	21273442
D002955	Leucovorin	Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 mRNA]	21213337
D002955	Leucovorin	Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 protein]	21213337
C070081	fulvestrant	fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]	18511507
C070081	fulvestrant	fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]	18511507
C070081	fulvestrant	fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]	18511507
C070081	fulvestrant	fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]	18511507
C070081	fulvestrant	fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of CYP11A1 protein]]	18511507
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP11A1 mRNA]	23209616
C070081	fulvestrant	fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]	18511507
C070081	fulvestrant	fulvestrant inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]	18511507
C039281	furan	furan results in increased expression of CYP11A1 mRNA	24632374\|2553966
D018757	GABA Modulators	CYP11A1 protein results in increased abundance of GABA Modulators	19125849
D019833	Genistein	Genistein affects the expression of CYP11A1 mRNA	18214933
D019833	Genistein	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of CYP11A1 mRNA	27181934
D019833	Genistein	Genistein results in decreased expression of CYP11A1 mRNA	21624456
D019833	Genistein	Genistein results in increased expression of CYP11A1 mRNA	21810550\|2255321
D019833	Genistein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA	28964809
C040641	genistin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA	28964809
C086566	glycitein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA	28964809
C433283	glycitin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA	28964809
C010974	glyphosate	glyphosate results in decreased activity of CYP11A1 protein	10964798
C081021	Go 6976	CRH protein inhibits the reaction [Go 6976 results in increased expression of CYP11A1 mRNA]	17170093
C081021	Go 6976	Go 6976 results in increased expression of CYP11A1 mRNA	17170093
D006064	Gonadotropins, Equine	"Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]"	19276399
C473027	GW 3965	GW 3965 results in decreased expression of CYP11A1 mRNA	17449538
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers metabolite results in increased expression of CYP11A1 mRNA	18248924\|1831309
D006063	Chorionic Gonadotropin	Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA]	26923738
D006063	Chorionic Gonadotropin	Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA	15930178\|2692373
D006063	Chorionic Gonadotropin	Chorionic Gonadotropin results in increased expression of CYP11A1 protein	15930178
D006063	Chorionic Gonadotropin	Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA]	15930178
D006063	Chorionic Gonadotropin	Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 protein]	15930178
C089796	hexabromocyclododecane	[hexabromocyclododecane co-treated with CGB3 protein] results in decreased expression of CYP11A1 mRNA	23347875
C089796	hexabromocyclododecane	[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of CYP11A1 mRNA	25447410
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of CYP11A1 mRNA	25447410
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of CYP11A1 protein	24365113
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of CYP11A1 protein	21296658
D006843	Hydrocarbons, Chlorinated	"Hydrocarbons, Chlorinated inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]"	24740604
D006854	Hydrocortisone	[resveratrol results in decreased acetylation of CYP11A1 protein] which results in increased chemical synthesis of Hydrocortisone	22585829
D019326	17-alpha-Hydroxyprogesterone	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of 17-alpha-Hydroxyprogesterone	23873838
C011582	IMOL S-140	IMOL S-140 results in increased expression of CYP11A1 mRNA	22446829
D007220	Industrial Waste	Industrial Waste results in decreased expression of CYP11A1 mRNA	26055946
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of CYP11A1 protein	17337753
D007649	Ketamine	Ketamine results in increased expression of CYP11A1 mRNA	20080153
D007654	Ketoconazole	Ketoconazole results in increased expression of CYP11A1 mRNA	17571688
D007654	Ketoconazole	Ketoconazole results in increased expression of CYP11A1 mRNA	26610754
C045492	kolaviron	kolaviron inhibits the reaction [Atrazine affects the expression of CYP11A1 mRNA]	22674924
D007854	Lead	Lead results in decreased expression of CYP11A1 protein	25981801
C008261	lead acetate	lead acetate results in decreased activity of CYP11A1 protein	12647776
C008261	lead acetate	lead acetate results in decreased expression of CYP11A1 mRNA	25270620
C008261	lead acetate	[cadmium acetate co-treated with lead acetate] results in decreased expression of CYP11A1 mRNA	21182167
C008261	lead acetate	lead acetate results in decreased expression of CYP11A1 protein	25981801
D001556	Lindane	Lindane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]	17080404
D001556	Lindane	Lindane results in decreased expression of CYP11A1 mRNA	17080404
D001556	Lindane	Lindane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]	15749814
D008044	Linuron	Linuron results in decreased expression of CYP11A1 mRNA	28705778
D008044	Linuron	Linuron results in decreased expression of CYP11A1 protein	28007637
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 mRNA]	21894328
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 protein]	21894328
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CYP11A1 mRNA	21894328
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CYP11A1 protein	21894328
C015329	lycopene	lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 protein]	19071209
D008345	Manganese	Manganese results in decreased expression of CYP11A1 protein	25981801
C025340	manganese chloride	manganese chloride inhibits the reaction [CYP11A1 protein results in increased chemical synthesis of Progesterone]	12699903
C025340	manganese chloride	manganese chloride results in decreased expression of CYP11A1 protein	12699903\|2598180
C545385	Mequindox	Mequindox results in decreased expression of CYP11A1 mRNA	19733641\|2137748
D008687	Metformin	Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]	16760380
D008694	Methamphetamine	Methamphetamine results in increased expression of CYP11A1 mRNA	19149911
D008726	Methoprene	Methoprene results in increased expression of CYP11A1 mRNA	19744992
D008727	Methotrexate	Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 mRNA]	21213337
D008727	Methotrexate	Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 protein]	21213337
D008727	Methotrexate	Methotrexate results in decreased expression of CYP11A1 mRNA	21213337
D008727	Methotrexate	Methotrexate results in decreased expression of CYP11A1 protein	21213337
D008731	Methoxychlor	Cholesterol inhibits the reaction [Methoxychlor results in decreased activity of CYP11A1 protein]	8431464
D008731	Methoxychlor	Methoxychlor binds to and results in decreased activity of CYP11A1 protein	8431464
D008731	Methoxychlor	Methoxychlor results in increased expression of CYP11A1 mRNA	12858341
D008731	Methoxychlor	Methoxychlor results in decreased expression of CYP11A1 mRNA	21514315\|2504810
D008731	Methoxychlor	Methoxychlor metabolite affects the activity of CYP11A1 protein	15336722
D008731	Methoxychlor	Methoxychlor metabolite inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	16737795
D008731	Methoxychlor	Methoxychlor metabolite results in decreased activity of CYP11A1 protein	16199348
D008731	Methoxychlor	Methoxychlor metabolite results in decreased expression of CYP11A1 mRNA	10684797
D008731	Methoxychlor	Methoxychlor results in decreased activity of CYP11A1 protein	16226009
D008731	Methoxychlor	Methoxychlor results in decreased expression of CYP11A1 protein	18848953
D008731	Methoxychlor	Methoxychlor results in increased expression of CYP11A1 mRNA	27663972
D008731	Methoxychlor	Methoxychlor results in increased expression of CYP11A1 protein	27663972
D008731	Methoxychlor	Methoxychlor promotes the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]	11226075
D008731	Methoxychlor	Methoxychlor results in increased expression of CYP11A1 mRNA	11226075
C005219	methyl cellosolve	Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA]	21427058
C005219	methyl cellosolve	methyl cellosolve results in decreased expression of CYP11A1 mRNA	21061450
C005219	methyl cellosolve	methyl cellosolve results in increased expression of CYP11A1 mRNA	21427058
C005219	methyl cellosolve	methyl cellosolve results in increased expression of CYP11A1 protein	21427058
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CYP11A1 mRNA"	20188158
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]"	20230807
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of CYP11A1 mRNA	24128854
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of CYP11A1 mRNA	29191790
D008797	Metyrapone	Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]	16935330
D008797	Metyrapone	Metyrapone results in increased expression of CYP11A1 mRNA	15265784
C016599	mono-(2-ethylhexyl)phthalate	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of CYP11A1 mRNA	27181934
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of CYP11A1 mRNA	22401849
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of CYP11A1 mRNA	27181934
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased activity of CYP11A1 protein	22525294
D008999	Monocrotophos	Monocrotophos results in increased expression of CYP11A1 mRNA	25317747
D008999	Monocrotophos	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Monocrotophos results in increased expression of CYP11A1 mRNA]	25317747
C523799	MRK 003	CYP11A1 results in increased susceptibility to MRK 003	19903844
C040015	myricetin	myricetin promotes the reaction [Cyclic AMP results in increased expression of CYP11A1 mRNA]	28668616
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Monocrotophos results in increased expression of CYP11A1 mRNA]	25317747
C483758	N(6)-phenyl-cAMP	N(6)-phenyl-cAMP results in increased expression of CYP11A1 mRNA	20663796
C026385	n-hexane	n-hexane affects the expression of CYP11A1 mRNA	26410608
C026385	n-hexane	n-hexane affects the expression of CYP11A1 protein	26410608
C026385	n-hexane	n-hexane affects the methylation of CYP11A1 promoter	26410608
D009538	Nicotine	Nicotine results in decreased expression of CYP11A1 mRNA	21971485\|2470967
D009538	Nicotine	Nicotine results in decreased expression of CYP11A1 protein	21971485
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]"	20230807
D009538	Nicotine	Nicotine results in decreased activity of CYP11A1 protein	28986172
D009538	Nicotine	Nicotine results in decreased expression of CYP11A1 mRNA	22265867\|2898617
D009538	Nicotine	Nicotine results in decreased expression of CYP11A1 protein	28986172
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine results in decreased expression of CYP11A1 mRNA	16303614
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine results in decreased expression of CYP11A1 protein	16303614
C063998	nodularin	[nodularin co-treated with Diethylnitrosamine] results in decreased activity of CYP11A1 protein	12112309
C025256	nonylphenol	nonylphenol affects the reaction [CGA protein results in increased expression of CYP11A1 protein]	19883722
C025256	nonylphenol	nonylphenol analog results in decreased expression of CYP11A1 mRNA	22771390
C025256	nonylphenol	nonylphenol affects the expression of CYP11A1 mRNA	17365614
D015282	Octreotide	NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]	23137853
D015282	Octreotide	Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	23137853
C108709	oleoyl-estrone	oleoyl-estrone results in increased expression of CYP11A1 mRNA	19793540
C016340	o,p'-DDT	"o,p'-DDT results in decreased expression of CYP11A1 mRNA"	23209616
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of CYP11A1 mRNA	24888373
D008939	Mitotane	Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]	22546480
D008939	Mitotane	Mitotane results in decreased activity of CYP11A1 protein	6094274
D008939	Mitotane	Mitotane results in decreased expression of CYP11A1 mRNA	22546480\|2325431
D008939	Mitotane	Mitotane results in decreased expression of CYP11A1 protein	22546480
D010100	Oxygen	Oxygen affects the expression of CYP11A1 mRNA	16740971
D010100	Oxygen	LEPA promotes the reaction [Oxygen deficiency results in increased expression of CYP11A1 mRNA]	22816610
D010100	Oxygen	Oxygen deficiency results in increased expression of CYP11A1 mRNA	22816610
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of CYP11A1 mRNA	18636392
D010269	Paraquat	Paraquat results in increased expression of CYP11A1 mRNA	18198484
D052638	Particulate Matter	Particulate Matter results in decreased expression of CYP11A1 mRNA	29165613
D052638	Particulate Matter	Particulate Matter results in increased expression of CYP11A1 mRNA	22861003
D052638	Particulate Matter	Particulate Matter affects the expression of CYP11A1 protein	22712718
D052638	Particulate Matter	Particulate Matter results in decreased expression of CYP11A1 mRNA	23257834
D052638	Particulate Matter	Particulate Matter results in increased expression of CYP11A1 mRNA	19699283\|2271271
D052638	Particulate Matter	Particulate Matter results in increased expression of CYP11A1 protein	19699283
C517782	pasireotide	NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]	23137853
C517782	pasireotide	pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	23137853
C098189	pentabromophenol	pentabromophenol results in increased expression of CYP11A1 mRNA	17447562
C003060	pentachlorobenzene	pentachlorobenzene results in decreased expression of CYP11A1 protein	24365113
C003060	pentachlorobenzene	pentachlorobenzene results in increased expression of CYP11A1 protein	21296658
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of CYP11A1 mRNA	21296122
C003072	perflubron	perflubron results in increased expression of CYP11A1 mRNA	25871633
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of CYP11A1 mRNA	17400581\|1939796
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of CYP11A1 protein	19397962
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CYP11A1 mRNA	23074026
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP11A1 mRNA	23399300
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CYP11A1 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP11A1 mRNA	21641976
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP11A1 mRNA	21712084\|2821976
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP11A1 protein	21712084\|2241460
C023036	perfluorooctanoic acid	PPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in decreased expression of CYP11A1 protein]	22414604
D026023	Permethrin	Permethrin analog results in decreased expression of CYP11A1 mRNA	21745691
D026023	Permethrin	Permethrin results in decreased expression of CYP11A1 mRNA	17463061\|1845585
D026023	Permethrin	Permethrin results in decreased expression of CYP11A1 protein	17463061
D015232	Dinoprostone	Dinoprostone results in increased expression of CYP11A1 mRNA	19001523
D010795	Phthalic Acids	Phthalic Acids inhibits the reaction [LHB protein results in increased expression of CYP11A1 mRNA]	19699292
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of CYP11A1 mRNA	15728792\|2106145
D010862	Pilocarpine	Pilocarpine results in increased expression of CYP11A1 protein	19125849
C077545	piperophos	piperophos results in decreased expression of CYP11A1 mRNA	20211256
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP11A1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid promotes the reaction [PPARA protein binds to CYP11A1 promoter]	23358192
D010936	Plant Extracts	Plant Extracts results in decreased activity of CYP11A1 protein	16254570
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP11A1 mRNA	16254570
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP11A1 protein	16254570
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of CYP11A1 mRNA	24888373
D059808	Polyphenols	Polyphenols results in decreased expression of CYP11A1 mRNA	16293270
D011284	Pregnenolone	CYP11A1 protein results in increased chemical synthesis of Pregnenolone	16054388\|1990047
D011284	Pregnenolone	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased chemical synthesis of Pregnenolone	23873838
D011284	Pregnenolone	CYP11A1 protein affects the chemical synthesis of Pregnenolone	10888668\|1619934
D011284	Pregnenolone	CYP11A1 protein mutant form results in increased chemical synthesis of Pregnenolone	22585829
D011284	Pregnenolone	CYP11A1 protein results in increased chemical synthesis of Pregnenolone	11226075
D011284	Pregnenolone	[CYP11A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Pregnenolone	11502818
C045362	prochloraz	prochloraz results in increased expression of CYP11A1 mRNA	21158436
C045362	prochloraz	prochloraz results in decreased expression of CYP11A1 mRNA	19733639
C045362	prochloraz	prochloraz results in increased expression of CYP11A1 mRNA	21470553
C035988	procymidone	procymidone results in increased expression of CYP11A1 mRNA	15686871
C024273	profenofos	profenofos results in increased expression of CYP11A1 mRNA	17569032
D011374	Progesterone	Progesterone results in increased expression of CYP11A1 mRNA	16303614\|2063139
D011374	Progesterone	Progesterone results in increased expression of CYP11A1 protein	16303614
D011374	Progesterone	CYP11A1 protein affects the abundance of Progesterone	11502818
D011374	Progesterone	CYP11A1 protein affects the chemical synthesis of Progesterone	15819722
D011374	Progesterone	"[2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP11A1 protein] which results in decreased chemical synthesis of Progesterone"	21664964
D011374	Progesterone	[bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Progesterone	18191889
D011374	Progesterone	CYP11A1 mRNA affects the abundance of Progesterone	10964264
D011374	Progesterone	CYP11A1 protein results in increased chemical synthesis of Progesterone	12699903
D011374	Progesterone	[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Progesterone	23873838
D011374	Progesterone	[FSHB protein results in increased expression of CYP11A1 mRNA] which results in increased abundance of Progesterone	22067323
D011374	Progesterone	GH1 protein promotes the reaction [[FSHB protein results in increased expression of CYP11A1 mRNA] which results in increased abundance of Progesterone]	22067323
D011374	Progesterone	IGF1 protein promotes the reaction [[FSHB protein results in increased expression of CYP11A1 mRNA] which results in increased abundance of Progesterone]	22067323
D011374	Progesterone	manganese chloride inhibits the reaction [CYP11A1 protein results in increased chemical synthesis of Progesterone]	12699903
D011692	Puromycin Aminonucleoside	CGB3 protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]	16574160
D011692	Puromycin Aminonucleoside	[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]	16574160
D011692	Puromycin Aminonucleoside	FSHB protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]	16574160
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA	16574160
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]	26209791\|2869742
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]	26209791
D011794	Quercetin	Quercetin promotes the reaction [Cyclic AMP results in increased expression of CYP11A1 mRNA]	28668616
D011794	Quercetin	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP11A1 mRNA]	23200735
D011794	Quercetin	Quercetin inhibits the reaction [Atrazine results in increased expression of CYP11A1 mRNA]	22372587\|2320073
D011794	Quercetin	Quercetin inhibits the reaction [FSHB protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]]	22372587
C435940	quercetin pentaacetate	quercetin pentaacetate promotes the reaction [Cyclic AMP results in increased expression of CYP11A1 mRNA]	28668616
C502851	quinocetone	quinocetone affects the expression of CYP11A1 mRNA	26296292
C059514	resveratrol	resveratrol results in decreased expression of CYP11A1 mRNA	24314921
C059514	resveratrol	resveratrol results in increased expression of CYP11A1 mRNA	24314921
C059514	resveratrol	resveratrol results in decreased acetylation of CYP11A1 protein	22585829
C059514	resveratrol	resveratrol results in increased expression of CYP11A1 protein	22585829
C059514	resveratrol	SIRT3 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein]	22585829
C059514	resveratrol	SIRT3 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]	22585829
C059514	resveratrol	SIRT5 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein]	22585829
C059514	resveratrol	SIRT5 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]	22585829
C059514	resveratrol	resveratrol inhibits the reaction [beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]]	16410306
C059514	resveratrol	resveratrol inhibits the reaction [Fluoxetine results in decreased expression of CYP11A1 mRNA]	26348076
C059514	resveratrol	resveratrol results in decreased expression of CYP11A1 mRNA	24524197
C059514	resveratrol	resveratrol results in increased expression of CYP11A1 mRNA	26348076
C059514	resveratrol	[Simvastatin co-treated with resveratrol] results in decreased expression of CYP11A1 mRNA	24524197
C059514	resveratrol	[resveratrol results in decreased acetylation of CYP11A1 protein] which results in increased chemical synthesis of Hydrocortisone	22585829
C059514	resveratrol	resveratrol results in decreased degradation of CYP11A1 protein	22585829
D012645	Selenomethionine	Selenomethionine results in increased expression of CYP11A1 mRNA	21762653
C009237	senecionine	senecionine results in increased expression of CYP11A1 mRNA	26100227
D012715	Sesame Oil	Sesame Oil results in increased expression of CYP11A1 mRNA	29191790
D012834	Silver	Silver analog results in increased expression of CYP11A1 mRNA	24447867
D012834	Silver	Silver analog results in decreased expression of CYP11A1 mRNA	27746313
D019821	Simvastatin	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11A1 mRNA	25055962
D019821	Simvastatin	[Simvastatin co-treated with resveratrol] results in decreased expression of CYP11A1 mRNA	24524197
C017947	sodium arsenite	sodium arsenite results in decreased expression of CYP11A1 mRNA	28414027
C016104	sodium bichromate	sodium bichromate results in increased expression of CYP11A1 mRNA	12325037
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CYP11A1 mRNA	22443068\|2786293
D013469	Sulpiride	Sulpiride results in increased expression of CYP11A1 mRNA	21427058
D013469	Sulpiride	Sulpiride results in increased expression of CYP11A1 protein	21427058
D014284	Triiodothyronine	Triiodothyronine affects the expression of CYP11A1 mRNA	21798688
D014284	Triiodothyronine	Triiodothyronine affects the reaction [LHB protein affects the expression of CYP11A1 mRNA]	21798688
D014284	Triiodothyronine	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]"	21726595
D014284	Triiodothyronine	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]]"	21726595
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]	21726595
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]	21726595
D013605	T-2 Toxin	[T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP11A1 protein	25962641
D013605	T-2 Toxin	[T-2 Toxin co-treated with CGA protein] results in decreased expression of CYP11A1 mRNA	25962641
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of CYP11A1 mRNA	26141394
D013739	Testosterone	[FSHB protein co-treated with Testosterone] results in increased expression of CYP11A1 mRNA	18535249
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of CYP11A1 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of CYP11A1 mRNA	21880219
D013739	Testosterone	Testosterone results in increased expression of CYP11A1 mRNA	21592394
D013739	Testosterone	CYP11A1 protein affects the chemical synthesis of Testosterone	15932923
D013739	Testosterone	Flutamide inhibits the reaction [Testosterone results in decreased expression of CYP11A1 mRNA]	22009729
D013739	Testosterone	Testosterone results in decreased expression of CYP11A1 mRNA	22009729
D013739	Testosterone	AR mutant form inhibits the reaction [Testosterone results in increased expression of CYP11A1 protein]	21273442
D013739	Testosterone	bicalutamide inhibits the reaction [Testosterone results in increased expression of CYP11A1 protein]	21273442
D013739	Testosterone	[bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Testosterone	18191889
D013739	Testosterone	Finasteride promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA]	21273442
D013739	Testosterone	formestane promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA]	21273442
D013739	Testosterone	Testosterone promotes the reaction [FSHB results in increased expression of CYP11A1 mRNA]	21273442
D013739	Testosterone	Testosterone results in increased expression of CYP11A1 mRNA	21273442
D013739	Testosterone	Testosterone results in increased expression of CYP11A1 protein	21273442
D013739	Testosterone	CYP11A1 protein affects the chemical synthesis of Testosterone	22564900
D013739	Testosterone	[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of CYP11A1 mRNA	18535249
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA	18160741
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP11A1 mRNA	18160741
C004648	testosterone enanthate	testosterone enanthate results in decreased expression of CYP11A1 mRNA	21427060\|2560346
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of CYP11A1 mRNA	24014645
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of CYP11A1 mRNA	26988606\|2830066
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA	25697571
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]	15223135
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 protein]	15223135
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP11A1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA	15223135\|2288988
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 protein	15223135
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP11A1 mRNA	16962184\|2821309
D013749	Tetrachlorodibenzodioxin	"Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]"	19276399
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA]	15930178
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 protein]	15930178
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA	11026553\|1614143
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of CYP11A1 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CYP11A1 protein	18755854\|1878702
C009495	titanium dioxide	titanium dioxide results in increased expression of CYP11A1 mRNA	23131501
C423915	TO-901317	TO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of CYP11A1 mRNA]	20926582
D014050	Toluene	Toluene results in increased expression of CYP11A1 mRNA	15707876
C483909	torcetrapib	torcetrapib results in increased expression of CYP11A1 mRNA	28235592
D014212	Tretinoin	Tretinoin results in increased expression of CYP11A1 mRNA	19744992
D014212	Tretinoin	Tretinoin results in increased expression of CYP11A1 mRNA	16621909
D014212	Tretinoin	[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA	21610156
D014212	Tretinoin	Tretinoin results in increased expression of CYP11A1 mRNA	16604517
C072782	tri-(2-chloroisopropyl)phosphate	tri-(2-chloroisopropyl)phosphate results in increased expression of CYP11A1 mRNA	22446829
C533760	tribromodiphenyl ether 28	tribromodiphenyl ether 28 metabolite results in increased expression of CYP11A1 mRNA	18248924
C011559	tributyltin	tributyltin results in decreased expression of CYP11A1 mRNA	20211155
D014236	Trichlorfon	Trichlorfon results in decreased activity of CYP11A1 protein	17350742
D014236	Trichlorfon	Trichlorfon results in decreased expression of CYP11A1 mRNA	17350742
D014236	Trichlorfon	Trichlorfon results in decreased expression of CYP11A1 protein	17350742
C012589	trichostatin A	trichostatin A results in increased expression of CYP11A1 mRNA	15901671
D014260	Triclosan	Triclosan results in decreased expression of CYP11A1 mRNA	19118620
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of CYP11A1 mRNA	26898711
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of CYP11A1 mRNA	23603146
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of CYP11A1 mRNA	22446829
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of CYP11A1 mRNA	26049154\|2618380
C001899	triptolide	triptolide results in decreased expression of and results in decreased activity of CYP11A1 protein	22592319
C001899	triptolide	triptolide results in decreased expression of CYP11A1 mRNA	22592319
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP11A1 mRNA"	23603146
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP11A1 mRNA"	22446829
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of CYP11A1 mRNA	26547027\|2713181
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of CYP11A1 mRNA	27912163
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of CYP11A1 mRNA	22446829
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of CYP11A1 mRNA	25808963
C031324	tris(chloroethyl)phosphate	[tris(chloroethyl)phosphate co-treated with CGB3 protein] results in decreased expression of CYP11A1 mRNA	26049154
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of CYP11A1 mRNA	22446829
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in decreased expression of CYP11A1 mRNA	26049154\|2618380
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of CYP11A1 mRNA	27019041
C113580	U 0126	U 0126 inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]	25253736
C113580	U 0126	U 0126 inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	25253736
C022884	undecane	undecane results in decreased expression of CYP11A1 protein	17337753
D014501	Uranium	Uranium analog results in decreased expression of CYP11A1 mRNA	27544493
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP11A1 mRNA	23152920
D014635	Valproic Acid	Valproic Acid results in increased expression of CYP11A1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the reaction [Colforsin affects the expression of CYP11A1 mRNA]	20726872
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP11A1 mRNA	19566492
D014635	Valproic Acid	Valproic Acid results in increased expression of CYP11A1 mRNA	14576182
D014635	Valproic Acid	Valproic Acid results in increased expression of CYP11A1 protein	14576182
D014635	Valproic Acid	Valproic Acid affects the expression of CYP11A1 mRNA	17963808
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of CYP11A1 mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CYP11A1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CYP11A1 mRNA	22861003
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of CYP11A1 protein	22712718
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CYP11A1 mRNA	23257834
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CYP11A1 mRNA	22712718
C025643	vinclozolin	vinclozolin results in increased expression of CYP11A1 mRNA	14967917
C025643	vinclozolin	vinclozolin results in increased expression of CYP11A1 protein	14967917
D004872	Ergocalciferols	CYP11A1 protein results in increased metabolism of Ergocalciferols	24382416
D014810	Vitamin E	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]	16298753
D014810	Vitamin E	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]	17280759
D014812	Vitamin K	Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 mRNA]	21894328
D014812	Vitamin K	Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 protein]	21894328
D014812	Vitamin K	Vitamin K affects the expression of CYP11A1 mRNA	16844298
D014812	Vitamin K	Vitamin K deficiency results in decreased expression of CYP11A1 mRNA	21894328
D014812	Vitamin K	Vitamin K deficiency results in decreased expression of CYP11A1 protein	21894328
C574123	walrycin A	walrycin A results in increased expression of CYP11A1 mRNA	22314385
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical analog results in increased expression of CYP11A1 mRNA"	21932247
C009687	wortmannin	wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]	25253736
C009687	wortmannin	wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	25253736
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA	18313992
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of CYP11A1 mRNA	27215404
D015039	Ziram	Ziram results in decreased activity of CYP11A1 protein	28973382
D015039	Ziram	Ziram results in decreased expression of CYP11A1 mRNA	28973382
D015039	Ziram	Ziram results in decreased expression of CYP11A1 protein	28973382

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005506	iron ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	25464930
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	-	IBA	21873635
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	-	IDA	11502818 18182448 21636783
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	-	ISS	-
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	-	TAS	-
GO:0020037	heme binding	-	IDA	21636783

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006700	C21-steroid hormone biosynthetic process	-	IBA	21873635
GO:0006700	C21-steroid hormone biosynthetic process	-	IDA	11502818 18182448 21636783
GO:0006700	C21-steroid hormone biosynthetic process	-	TAS	-
GO:0006704	glucocorticoid biosynthetic process	-	IBA	21873635
GO:0008203	cholesterol metabolic process	-	IBA	21873635
GO:0008203	cholesterol metabolic process	-	IDA	21636783
GO:0008203	cholesterol metabolic process	-	IMP	18182448
GO:0008203	cholesterol metabolic process	-	ISS	-
GO:0016125	sterol metabolic process	-	TAS	-
GO:0034650	cortisol metabolic process	-	IBA	21873635
GO:0042359	vitamin D metabolic process	-	ISS	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0071375	cellular response to peptide hormone stimulus	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	ISS	-
GO:0005743	mitochondrial inner membrane	-	IBA	21873635
GO:0005743	mitochondrial inner membrane	-	ISS	-
GO:0005759	mitochondrial matrix	-	TAS	-

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-196071	Metabolism of steroid hormones	TAS
R-HSA-196108	Pregnenolone biosynthesis	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-211976	Endogenous sterols	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5579026	Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	TAS
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	TAS
R-HSA-5668914	Diseases of metabolism	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23197595	Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)	O'Shaughnessy PJ	Mol Hum Reprod
29429410	The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. (2018 Feb 12)	Johnston ZC	BMC Med
24847019	In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul)	Fowler PA	Hum Reprod