Gene: FREM1

158326
BNAR|C9orf143|C9orf145|C9orf154|MOTA|TILRR|TRIGNO2
FRAS1 related extracellular matrix 1
protein-coding
9p22.3
Ensembl:ENSG00000164946 MIM:608944 Vega:OTTHUMG00000019575 UniprotKB:Q5H8C1
NG_017005.2
SNP Mapped
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.664e-1 (AD)  1.665e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1389733chr9:14791717 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2291681chr9:14790843 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10117516chr9:14749436 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIP20.76
HAPLN10.732
ENTPD30.724
GAD20.719
VWC20.716
NXPH20.715
LAMB10.713
SLC10A40.712
PPP4R40.711
TASP10.707

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.525
HEBP2-0.503
RAB13-0.466
RARRES3-0.441
AKR1C3-0.437
AZGP1-0.435
PXDC1-0.434
TGFB3-0.434
TMEM176A-0.432
SERPINA3-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C547126AZM551248AZM551248 results in decreased expression of FREM1 mRNA22323515
C487081belinostatbelinostat results in decreased expression of FREM1 mRNA27188386
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of FREM1 mRNA21635667
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of FREM1 mRNA21635667
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FREM1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of FREM1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FREM1 mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of FREM1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FREM1 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of FREM1 mRNA25979313
D019327Copper SulfateCopper Sulfate results in decreased expression of FREM1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FREM1 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of FREM1 promoter27989131
D002117CalcitriolCalcitriol results in increased expression of FREM1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of FREM1 mRNA21592394
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of FREM1 gene23221805
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of FREM1 mRNA"21635667
C042720mercuric bromidemercuric bromide results in increased expression of FREM1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FREM1 mRNA23103053
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FREM1 mRNA"25554681
D009532NickelNickel results in decreased expression of FREM1 mRNA25583101
C007350nitrofennitrofen results in decreased expression of FREM1 mRNA26382659
C007350nitrofennitrofen results in decreased expression of FREM1 protein26382659
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FREM1 mRNA27935865
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of FREM1 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FREM1 mRNA26272509
D011794QuercetinQuercetin affects the expression of FREM1 mRNA21632981
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of FREM1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FREM1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FREM1 mRNA20106945|2163298
D014212TretinoinTretinoin results in decreased expression of FREM1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of FREM1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of FREM1 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of FREM1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FREM1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of FREM1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of FREM1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FREM1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of FREM1 mRNA26682919
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FREM1 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030246carbohydrate binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007154cell communication-IEA-  
GO:0007160cell-matrix adhesion-IEA-  
GO:0097094craniofacial suture morphogenesis-IMP21931569  
GO ID GO Term Qualifier Evidence PubMed
GO:0005604basement membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal