Gene: CYP11B1

1584
CPN1|CYP11B|FHI|P450C11
cytochrome P450 family 11 subfamily B member 1
protein-coding
8q24.3
Ensembl:ENSG00000160882 MIM:610613 Vega:OTTHUMG00000164637 UniprotKB:P15538
NG_007954.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.807e-1 (AD)  8.155e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21298978chr8:143961391CYP11B1Promoter5.025e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP17A10.749
HSD3B20.666
OR51A20.503
SULT2A10.502
AADAC0.484
FGF30.436
PRSS10.412
GRP0.407
PRAMEF70.406
GSTA50.405

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTC-0.211
BRCA1-0.207
SERINC5-0.206
S100A12-0.205
CLDN20-0.204
IL1R2-0.202
DTHD1-0.201
HOMEZ-0.2
MYBL1-0.197
STEAP1B-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C00358211-hydroxyandrostenedione11-hydroxyandrostenedione results in decreased expression of CYP11B1 mRNA15858796
C03368918-hydroxycortisolCYP11B1 protein affects the chemical synthesis of 18-hydroxycortisol15356073
C04250918-hydroxydeoxycorticosterone18-hydroxydeoxycorticosterone results in decreased activity of CYP11B1 protein11549669
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with AGT protein] affects the expression of CYP11B1 mRNA"19900470
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B1 mRNA"19900470
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene results in increased expression of CYP11B1 mRNA"19900470
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]"18651133
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene results in decreased activity of CYP11B1 protein"18651133
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"CYP11B1 protein results in increased metabolism of 1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"19900470
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with LHB protein] results in decreased expression of CYP11B1 mRNA"23333615
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"CYP11B1 protein results in increased metabolism of 1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"18651133
C0337291H,1H,2H,2H-perfluorodecanol"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B1 mRNA"20615422
C0337291H,1H,2H,2H-perfluorodecanol"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B1 protein"20615422
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]"18651133
C0948592,2',3,3',4,6'-hexachlorobiphenyl"2,2',3,3',4,6'-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA"16396990
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP11B1 mRNA"25510870
C1201292,2',3,4',5',6-hexachlorobiphenyl"2,2',3,4',5',6-hexachlorobiphenyl metabolite inhibits the reaction [2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA]"16216300
C1201292,2',3,4',5',6-hexachlorobiphenyl"2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA"16216300
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP11B1 mRNA"25765474
C5112952,2',4,4'-tetrabromodiphenyl ether"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CYP11B1 mRNA22172629
C0876672,3,3',4,4',5-hexachlorobiphenyl"2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA"16396990
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP11B1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B1 mRNA"25765474
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP11B1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl metabolite inhibits the reaction [2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA]"16216300
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA"16216300
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP11B1 mRNA"25510870
C1045642-(4-acetoxyphenyl)-2-chloro-N-methylethylamine2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine results in decreased activity of CYP11B1 protein9037251
C1045642-(4-acetoxyphenyl)-2-chloro-N-methylethylamine2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine results in decreased activity of CYP11B1 protein9037251
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP11B1 mRNA"25510870
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP11B1 mRNA"16396990
C0273093,4,5,3',4',5'-hexachlorobiphenyl"3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA"16396990
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP11B1 protein"15703266
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA"15703266|1621630
C0230353,4,5,3',4'-pentachlorobiphenyl"3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA]"16396990
C0230353,4,5,3',4'-pentachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
C0230353,4,5,3',4'-pentachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B1 mRNA"25765474
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA]"16396990
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]"22172629
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone results in increased expression of CYP11B1 mRNA"16396990|2217262
C5092883',4'-dimethoxyflavone"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [3',4'-dimethoxyflavone results in increased expression of CYP11B1 mRNA]"22172629
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of CYP11B1 mRNA"26751127
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CYP11B1 mRNA"26751127
D000111AcetylcysteineAcetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B1 mRNA]25617244
D000111AcetylcysteineAcetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B1 mRNA]25617244
D000111AcetylcysteineAcetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]25617244
D000242Cyclic AMPCyclic AMP results in increased expression of CYP11B1 mRNA22172629
D000242Cyclic AMPN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of CYP11B1 mRNA]22172629
D000324Adrenocorticotropic HormoneAdrenocorticotropic Hormone results in increased expression of CYP11B1 mRNA16410306
C011512alpha-naphthoflavonealpha-naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]22172629
C011512alpha-naphthoflavonealpha-naphthoflavone results in increased expression of CYP11B1 mRNA22172629
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CYP11B1 mRNA21298039
C530884anacetrapibAcetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B1 mRNA]25617244
C530884anacetrapibanacetrapib results in increased expression of CYP11B1 mRNA25617244
D000735AndrostenedioneCYP11B1 protein results in increased hydroxylation of Androstenedione12153581
D047310ApigeninApigenin results in decreased expression of CYP11B1 mRNA22172629
C061004benidipinebenidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]18331727
C061004benidipinebenidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA]18331727
D019324beta-Naphthoflavonebeta-Naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]22172629
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of CYP11B1 mRNA22172629
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone affects the expression of CYP11B1 mRNA26751127
C006780bisphenol Abisphenol A results in increased expression of CYP11B1 mRNA26751127
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CYP11B1 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of CYP11B1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CYP11B1 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B1 mRNA22079614|2217262
D0151248-Bromo Cyclic Adenosine MonophosphateMitotane affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B1 mRNA]22546480
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11B1 mRNA21610156
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CYP11B1 mRNA25607892
D002110CaffeineCaffeine results in decreased expression of CYP11B1 mRNA25868845
D005576Colforsin"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B1 mRNA"19900470
D005576ColforsinColforsin results in increased activity of CYP11B1 protein12525251
D005576ColforsinColforsin results in increased expression of CYP11B1 mRNA17080404|1916446
D005576ColforsinLindane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA]17080404
D005576Colforsin"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]"18651133
D005576Colforsin"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]"18651133
D005576ColforsinColforsin results in increased activity of CYP11B1 protein18651133
D005576ColforsinEtomidate inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]18651133
D003345CorticosteroneCYP11B1 protein results in increased chemical synthesis of Corticosterone16054388
D003345CorticosteroneCYP11B1 protein affects the chemical synthesis of Corticosterone11196410
C020728cyadoxcyadox metabolite affects the expression of CYP11B1 protein26802905
C020728cyadoxcyadox metabolite results in decreased expression of CYP11B1 mRNA26802905
C020728cyadoxProanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B1 protein]26802905
C020728cyadoxProanthocyanidins inhibits the reaction [cyadox metabolite results in decreased expression of CYP11B1 mRNA]26802905
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in decreased expression of CYP11B1 mRNA28454766
C411602dalcetrapibAcetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B1 mRNA]25617244
C411602dalcetrapibdalcetrapib results in increased expression of CYP11B1 mRNA25617244
C411602dalcetrapibRotenone promotes the reaction [dalcetrapib results in increased expression of CYP11B1 mRNA]25617244
D003350CortodoxoneCYP11B1 protein affects the metabolism of Cortodoxone15522937|1578066
D003350CortodoxoneCYP11B1 protein results in increased metabolism of Cortodoxone19900470
C007262deoxynivalenoldeoxynivalenol results in increased expression of CYP11B1 mRNA22982764
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CYP11B1 mRNA21266533
C089799diheptyl phthalatediheptyl phthalate results in decreased expression of CYP11B1 mRNA22112501
C025605diisobutyl phthalatediisobutyl phthalate results in decreased expression of CYP11B1 mRNA22112501
C012125diisononyl phthalatediisononyl phthalate results in decreased expression of CYP11B1 mRNA22112501
C027387di-n-hexyl phthalatedi-n-hexyl phthalate results in decreased expression of CYP11B1 mRNA22112501
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of CYP11B1 mRNA22112501|2505596
C034171di-n-pentyl phthalate[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B1 mRNA25055962
C100264enniatinsenniatins results in increased expression of CYP11B1 mRNA25625232
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of CYP11B1 mRNA21420147
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CYP11B1 mRNA25607892
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in decreased expression of CYP11B1 mRNA28454766
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP11B1 mRNA15858796
D005045EtomidateEtomidate inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]18651133
D005045EtomidateEtomidate results in decreased activity of CYP11B1 protein18651133
D017316FadrozoleFadrozole results in decreased activity of CYP11B1 protein15743198|1577142
C039281furanfuran results in increased expression of CYP11B1 mRNA27387713
C576694GKT137831GKT137831 inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]25617244
C089796hexabromocyclododecane"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
D006854Hydrocortisone"3',4'-dimethoxyflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]"22172629
D006854Hydrocortisonealpha-naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]22172629
D006854Hydrocortisonebeta-Naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]22172629
D006854HydrocortisoneCYP11B1 protein affects the metabolism of Hydrocortisone16030167
D006854HydrocortisoneCYP11B1 protein results in increased chemical synthesis of Hydrocortisone16054388|1990047
D006854HydrocortisoneCYP11B1 protein results in increased chemical synthesis of Hydrocortisone22172629
D003900DesoxycorticosteroneCYP11B1 protein affects the metabolism of Desoxycorticosterone16054388
D003900DesoxycorticosteroneCYP11B1 protein results in increased chemical synthesis of Desoxycorticosterone19900470
D003900DesoxycorticosteroneCYP11B1 protein affects the metabolism of Desoxycorticosterone11196410
D003900DesoxycorticosteronePlant Extracts inhibits the reaction [Desoxycorticosterone binds to CYP11B1 protein]15666820
D007189IndansIndans results in decreased activity of CYP11B1 protein15743198
D007654KetoconazoleKetoconazole results in decreased activity of CYP11B1 protein15771425
D007654KetoconazoleKetoconazole results in decreased activity of CYP11B1 protein15743198
D001556LindaneLindane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA]17080404
C545385MequindoxMequindox metabolite results in decreased expression of CYP11B1 mRNA26802905
C545385MequindoxMequindox metabolite results in decreased expression of CYP11B1 protein26802905
C545385MequindoxMequindox results in decreased expression of CYP11B1 protein26802905
C545385MequindoxProanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B1 protein]26802905
C545385MequindoxProanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B1 mRNA]26802905
C545385MequindoxMequindox results in decreased expression of CYP11B1 mRNA19733641
D008696MethandrostenoloneCYP11B1 protein results in increased chemical synthesis of Methandrostenolone analog22885098
D008696MethandrostenoloneCYP11B1 protein results in increased metabolism of Methandrostenolone22885098
C004925methylmercuric chloride"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
D008797MetyraponeMetyrapone results in increased expression of CYP11B1 protein9832454
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [3',4'-dimethoxyflavone results in increased expression of CYP11B1 mRNA]"22172629
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of CYP11B1 mRNA]22172629
D009538NicotineNicotine results in decreased expression of CYP11B1 mRNA24709674
C118580octylmethoxycinnamateoctylmethoxycinnamate results in increased expression of CYP11B1 mRNA28235592
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CYP11B1 mRNA25607892
C108709oleoyl-estroneoleoyl-estrone results in increased expression of CYP11B1 mRNA19793540
D008939MitotaneMitotane affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B1 mRNA]22546480
D008939MitotaneMitotane results in decreased expression of CYP11B1 protein23696597
D008939MitotaneMitotane results in increased expression of CYP11B1 mRNA19900470|2254648
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP11B1 mRNA"25510870
C003072perflubronperflubron results in increased expression of CYP11B1 mRNA25871633
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYP11B1 mRNA25765474
C076994perfluorooctane sulfonic acid"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
C076994perfluorooctane sulfonic acid"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B1 mRNA"25765474
D010936Plant ExtractsPlant Extracts inhibits the reaction [Desoxycorticosterone binds to CYP11B1 protein]15666820
D010936Plant ExtractsPlant Extracts results in decreased activity of CYP11B1 protein12766951
D011189Potassium Chloridebenidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA]18331727
D011189Potassium ChloridePotassium Chloride results in increased expression of CYP11B1 mRNA18331727
D044945ProanthocyanidinsProanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B1 protein]26802905
D044945ProanthocyanidinsProanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B1 protein]26802905
D044945ProanthocyanidinsProanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 mRNA]26802905
D044945ProanthocyanidinsProanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 protein]26802905
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [cyadox metabolite results in decreased expression of CYP11B1 mRNA]26802905
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B1 mRNA]26802905
C045362prochlorazprochloraz results in decreased expression of CYP11B1 mRNA19733639
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in decreased expression of CYP11B1 mRNA28454766
D011794QuercetinQuercetin results in decreased expression of CYP11B1 mRNA22172629
C502851quinocetoneProanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 mRNA]26802905
C502851quinocetoneProanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 protein]26802905
C502851quinocetonequinocetone metabolite affects the expression of CYP11B1 mRNA26802905
C502851quinocetonequinocetone metabolite affects the expression of CYP11B1 protein26802905
D012402RotenoneRotenone promotes the reaction [dalcetrapib results in increased expression of CYP11B1 mRNA]25617244
D019821Simvastatin[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B1 mRNA25055962
D013739TestosteroneTestosterone results in decreased activity of CYP11B1 protein1655649
D013739TestosteroneTestosterone results in decreased expression of CYP11B1 mRNA1655649
D013739TestosteroneTestosterone results in decreased expression of CYP11B1 protein1655649
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B1 mRNA"25765474
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP11B1 mRNA16254025
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CYP11B1 mRNA28973375
D013764TetrahydronaphthalenesTetrahydronaphthalenes results in decreased activity of CYP11B1 protein15743198
C017953tetramethylpyrazinetetramethylpyrazine results in increased expression of CYP11B1 mRNA15520497
D014050TolueneToluene affects the expression of CYP11B1 mRNA18653662
C483909torcetrapibAcetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]25617244
C483909torcetrapibGKT137831 inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]25617244
C483909torcetrapibtorcetrapib results in increased expression of CYP11B1 mRNA19164467|2561724
C011559tributyltin"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA"25765474
D014635Valproic AcidValproic Acid results in increased methylation of CYP11B1 gene29154799
C574123walrycin Awalrycin A results in increased expression of CYP11B1 mRNA22314385
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CYP11B1 mRNA"21722693

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004507steroid 11-beta-monooxygenase activity-IBA21873635  
GO:0004507steroid 11-beta-monooxygenase activity-IDA2256920  8506298  
GO:0004507steroid 11-beta-monooxygenase activity-IMP2022736  
GO:0004507steroid 11-beta-monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0020037heme binding-IC2256920  
GO:0047783corticosterone 18-monooxygenase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006700C21-steroid hormone biosynthetic process-IBA21873635  
GO:0006700C21-steroid hormone biosynthetic process-IDA2256920  
GO:0006704glucocorticoid biosynthetic process-IBA21873635  
GO:0006704glucocorticoid biosynthetic process-TAS-  
GO:0006955immune response-TAS12452430  
GO:0008203cholesterol metabolic process-IBA21873635  
GO:0008217regulation of blood pressure-IMP2022736  
GO:0016125sterol metabolic process-TAS-  
GO:0032342aldosterone biosynthetic process-IBA21873635  
GO:0032342aldosterone biosynthetic process-IDA2256920  
GO:0032342aldosterone biosynthetic process-IMP19342457  
GO:0032870cellular response to hormone stimulus-IEP19342457  
GO:0034650cortisol metabolic process-IBA21873635  
GO:0034651cortisol biosynthetic process-IDA8506298  
GO:0034651cortisol biosynthetic process-IMP2022736  19342457  
GO:0035865cellular response to potassium ion-IEP19342457  
GO:0042593glucose homeostasis-TAS16114325  
GO:0055114oxidation-reduction process-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA2256920  
GO:0005743mitochondrial inner membrane-IBA21873635  
GO:0005743mitochondrial inner membrane-IC8506298  
GO:0005743mitochondrial inner membrane-TAS15026188  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-194002Glucocorticoid biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579017Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19443378Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort. (2009 May)Fontana LAnticancer Res
15055249CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study. (2004 Jan)Matsubara MHypertens Res